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Protein

BH3-interacting domain death agonist

Gene

BID

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-GGA-111453. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
R-GGA-75108. Activation, myristolyation of BID and translocation to mitochondria.

Names & Taxonomyi

Protein namesi
Recommended name:
BH3-interacting domain death agonist
Gene namesi
Name:BID
ORF Names:RCJMB04_7d15
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193BH3-interacting domain death agonistPRO_0000223373Add
BLAST

Proteomic databases

PaxDbiQ8JGM8.
PRIDEiQ8JGM8.

Interactioni

Subunit structurei

Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021253.

Structurei

3D structure databases

ProteinModelPortaliQ8JGM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi87 – 10115BH3Add
BLAST

Domaini

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family.

Phylogenomic databases

eggNOGiENOG410IVZ7. Eukaryota.
ENOG410ZF8F. LUCA.
HOGENOMiHOG000010016.
HOVERGENiHBG001703.
InParanoidiQ8JGM8.
KOiK04726.
OrthoDBiEOG73V6MW.
PhylomeDBiQ8JGM8.
TreeFamiTF102047.

Family and domain databases

InterProiIPR010479. BID.
[Graphical view]
PfamiPF06393. BID. 1 hit.
[Graphical view]
PIRSFiPIRSF038018. BID. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JGM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDIYSNGS DHMERMLLFA FLAESSGCEF QEQLPSLQSQ GVLCSVKDAL
60 70 80 90 100
CYDSDGELQT DGNRSGHLQN GELVPDPEVN EAIVRTIAAQ LAEIGDQLDK
110 120 130 140 150
QIKAKVVNDL VQHFLNENLP REEITRCLSQ AVEGLARAIP SDLEQEKAML
160 170 180 190
VLAMLLTKKV ANQMPSLLQR VFSTTVNYIS QHFHNYIVRM LRE
Length:193
Mass (Da):21,678
Last modified:February 21, 2006 - v2
Checksum:iBB881DBC5079214B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY112660 mRNA. Translation: AAM48284.1.
AJ719847 mRNA. Translation: CAG31506.1.
RefSeqiNP_989883.2. NM_204552.2.
XP_015139899.1. XM_015284413.1.
UniGeneiGga.1234.

Genome annotation databases

GeneIDi395236.
KEGGigga:395236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY112660 mRNA. Translation: AAM48284.1.
AJ719847 mRNA. Translation: CAG31506.1.
RefSeqiNP_989883.2. NM_204552.2.
XP_015139899.1. XM_015284413.1.
UniGeneiGga.1234.

3D structure databases

ProteinModelPortaliQ8JGM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021253.

Proteomic databases

PaxDbiQ8JGM8.
PRIDEiQ8JGM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395236.
KEGGigga:395236.

Organism-specific databases

CTDi637.

Phylogenomic databases

eggNOGiENOG410IVZ7. Eukaryota.
ENOG410ZF8F. LUCA.
HOGENOMiHOG000010016.
HOVERGENiHBG001703.
InParanoidiQ8JGM8.
KOiK04726.
OrthoDBiEOG73V6MW.
PhylomeDBiQ8JGM8.
TreeFamiTF102047.

Enzyme and pathway databases

ReactomeiR-GGA-111453. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
R-GGA-75108. Activation, myristolyation of BID and translocation to mitochondria.

Miscellaneous databases

NextBioi20815325.
PROiQ8JGM8.

Family and domain databases

InterProiIPR010479. BID.
[Graphical view]
PfamiPF06393. BID. 1 hit.
[Graphical view]
PIRSFiPIRSF038018. BID. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BID expression in the hen ovary."
    Bridgham J.T., Johnson A.L.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiBID_CHICK
AccessioniPrimary (citable) accession number: Q8JGM8
Secondary accession number(s): Q5ZL87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: March 16, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.