Q8JGM8 (BID_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BH3-interacting domain death agonist

Gene names

Name:	BID
ORF Names:	RCJMB04_7d15

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces caspases and apoptosis. Counters the protective effect of Bcl-2 By similarity.
Subunit structure	Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 By similarity.
Subcellular location	Cytoplasm By similarity.
Domain	Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	BH3-interacting domain death agonist		PRO_0000223373
Regions
	Motif	87 – 101	15	BH3

Sequences

	Sequence		Length	Mass (Da)
	Q8JGM8 [UniParc]. Last modified February 21, 2006. Version 2. Checksum: BB881DBC5079214B	FASTA	193	21,678
	10 20 30 40 50 60 MEQDIYSNGS DHMERMLLFA FLAESSGCEF QEQLPSLQSQ GVLCSVKDAL CYDSDGELQT 70 80 90 100 110 120 DGNRSGHLQN GELVPDPEVN EAIVRTIAAQ LAEIGDQLDK QIKAKVVNDL VQHFLNENLP 130 140 150 160 170 180 REEITRCLSQ AVEGLARAIP SDLEQEKAML VLAMLLTKKV ANQMPSLLQR VFSTTVNYIS 190 QHFHNYIVRM LRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BID expression in the hen ovary." Bridgham J.T., Johnson A.L. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY112660 mRNA. Translation: AAM48284.1. AJ719847 mRNA. Translation: CAG31506.1.
IPI	IPI00681652.
RefSeq	NP_989883.2. NM_204552.2.
UniGene	Gga.1234.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8JGM8.
Proteomic databases
PRIDE	Q8JGM8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000021284; ENSGALP00000021253; ENSGALG00000013039.
GeneID	395236.
KEGG	gga:395236.
Organism-specific databases
CTD	637.
Phylogenomic databases
eggNOG	veNOG20360.
GeneTree	ENSGT00390000002868.
HOGENOM	HBG278752.
HOVERGEN	HBG001703.
InParanoid	Q8JGM8.
OrthoDB	EOG4J9N1J.
Family and domain databases
InterPro	IPR010479. BID. [Graphical view]
KO	K04726.
Pfam	PF06393. BID. 1 hit. [Graphical view]
PIRSF	PIRSF038018. BID. 1 hit.
PROSITE	PS01259. BH3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BID_CHICK

Accession

Primary (citable) accession number: Q8JGM8
Secondary accession number(s): Q5ZL87

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	February 21, 2006
Last modified:	November 16, 2011
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program