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Q8JGM4

- QSOX1_CHICK

UniProt

Q8JGM4 - QSOX1_CHICK

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Protein
Sulfhydryl oxidase 1
Gene
QSOX1, QSCN6, QSOX, SOX
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.1 Publication

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

Binds 1 FAD per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801Nucleophile By similarity
Active sitei83 – 831Nucleophile By similarity
Binding sitei415 – 4151FAD By similarity
Binding sitei422 – 4221FAD By similarity
Binding sitei426 – 4261FAD By similarity
Binding sitei461 – 4611FAD By similarity
Binding sitei465 – 4651FAD By similarity
Binding sitei510 – 5101FAD By similarity
Binding sitei513 – 5131FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi488 – 4958FAD By similarity

GO - Molecular functioni

  1. flavin-linked sulfhydryl oxidase activity Source: UniProtKB
  2. protein disulfide isomerase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 1 (EC:1.8.3.2)
Alternative name(s):
Quiescin Q6
Gene namesi
Name:QSOX1
Synonyms:QSCN6, QSOX, SOX
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei707 – 72721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. integral component of Golgi membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242 Reviewed prediction
Add
BLAST
Chaini43 – 743701Sulfhydryl oxidase 1
PRO_0000249537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 83Redox-active By similarity
Glycosylationi254 – 2541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi371 – 3711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi401 – 4011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi407 ↔ 419 By similarity
Disulfide bondi459 ↔ 462 By similarity
Disulfide bondi519 ↔ 522 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8JGM4.

Expressioni

Tissue specificityi

Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells. Highly expressed in the active secretory tissue of the oviduct.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006256.

Structurei

3D structure databases

ProteinModelPortaliQ8JGM4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 166124Thioredoxin
Add
BLAST
Domaini410 – 513104ERV/ALR sulfhydryl oxidase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi578 – 60326Glu-rich
Add
BLAST
Compositional biasi680 – 6845Poly-Glu

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237986.
HOGENOMiHOG000231631.
HOVERGENiHBG080360.
InParanoidiQ8JGM4.
KOiK10758.
PhylomeDBiQ8JGM4.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JGM4-1 [UniParc]FASTAAdd to Basket

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MWRRRARSGG GGGGGGGGAA PRCRWWPAVL ALLAAALPAA RSRSLYSPSD    50
PLELLGADTA ERRLLGSPSA WAVEFFASWC GHCIHFAPTW RALAEDVREW 100
RPAVMIAALD CADEANQQVC ADFGITGFPT LKFFRAFSKK AEDGIRIAHP 150
TATVADLRRA IITNLEQSGD AWPPACPPLE PASAEEVRSF FHRNTERYLA 200
LIFEQSNSFV GREVALDLLQ YENVAVRRVL SSEEELVEKF GVTTFPSAYL 250
LLRNGSFSRL PVHAEARSFY TYYLQTLSGV TRGSYRLNVT GSAINETRAL 300
QPAQADRSKV YVADLESTVH YTLRVEAGRP AVLAGAQLAA LKCYVATLAK 350
YFPGRPSVQT FLQSLDSWLR NWTEPELPRS ALKEAVKNKE DASPAAVLPT 400
NVTWVGCRGS EPHFRGYPCG LWTIFHLLTV QAAQGGPDEE LPLEVLNTMR 450
CYVKHFFGCQ ECAQHFEAMA AKSMDQVKSR REAVLWLWSH HNEVNARLAG 500
GDTEDPQFPK LQWPPPDMCP QCHREERGVH TWDEAAVLSF LKEHFSLGNL 550
YLDHAIPIPM AGEEAAASAR LSTAGLREKE EEERKEEEEE GEKETEKPHR 600
EGETGRPGSS ELRRPSIVRR NPRLRALGED IVDLDSFSEQ HFKSKALRAA 650
GRHRRLSKRD TVALHHDAGW ERLQVPESRE EEEEGGVLRR SPWLRVLGLG 700
FSRLDVSLCI ALYFLSSMCL LGMYTFFRLR TRARKGRPGF PVA 743
Length:743
Mass (Da):83,079
Last modified:October 1, 2002 - v1
Checksum:i44512B7EBB0B9769
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY112666 mRNA. Translation: AAM44079.1.
RefSeqiNP_989456.1. NM_204125.1.
UniGeneiGga.148.

Genome annotation databases

GeneIDi373914.
KEGGigga:373914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY112666 mRNA. Translation: AAM44079.1 .
RefSeqi NP_989456.1. NM_204125.1.
UniGenei Gga.148.

3D structure databases

ProteinModelPortali Q8JGM4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000006256.

Proteomic databases

PRIDEi Q8JGM4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 373914.
KEGGi gga:373914.

Organism-specific databases

CTDi 5768.

Phylogenomic databases

eggNOGi NOG237986.
HOGENOMi HOG000231631.
HOVERGENi HBG080360.
InParanoidi Q8JGM4.
KOi K10758.
PhylomeDBi Q8JGM4.

Miscellaneous databases

NextBioi 20813446.
PROi Q8JGM4.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes."
    Thorpe C., Hoober K.L., Raje S., Glynn N.M., Burnside J., Turi G.K., Coppock D.L.
    Arch. Biochem. Biophys. 405:1-12(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.

Entry informationi

Entry nameiQSOX1_CHICK
AccessioniPrimary (citable) accession number: Q8JGM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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