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Q8JGM4 (QSOX1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfhydryl oxidase 1

EC=1.8.3.2
Alternative name(s):
Quiescin Q6
Gene names
Name:QSOX1
Synonyms:QSCN6, QSOX, SOX
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length743 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity. Ref.1

Catalytic activity

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Homodimer. Ref.1

Subcellular location

Golgi apparatus membrane; Single-pass membrane protein By similarity.

Tissue specificity

Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells. Highly expressed in the active secretory tissue of the oviduct. Ref.1

Sequence similarities

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

Contains 1 ERV/ALR sulfhydryl oxidase domain.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4242 Potential
Chain43 – 743701Sulfhydryl oxidase 1
PRO_0000249537

Regions

Transmembrane707 – 72721Helical; Potential
Domain43 – 166124Thioredoxin
Domain410 – 513104ERV/ALR sulfhydryl oxidase
Nucleotide binding488 – 4958FAD By similarity
Compositional bias578 – 60326Glu-rich
Compositional bias680 – 6845Poly-Glu

Sites

Active site801Nucleophile By similarity
Active site831Nucleophile By similarity
Binding site4151FAD By similarity
Binding site4221FAD By similarity
Binding site4261FAD By similarity
Binding site4611FAD By similarity
Binding site4651FAD By similarity
Binding site5101FAD By similarity
Binding site5131FAD By similarity

Amino acid modifications

Glycosylation2541N-linked (GlcNAc...) Potential
Glycosylation2881N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation3711N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential
Disulfide bond80 ↔ 83Redox-active By similarity
Disulfide bond407 ↔ 419 By similarity
Disulfide bond459 ↔ 462 By similarity
Disulfide bond519 ↔ 522 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8JGM4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 44512B7EBB0B9769

FASTA74383,079
        10         20         30         40         50         60 
MWRRRARSGG GGGGGGGGAA PRCRWWPAVL ALLAAALPAA RSRSLYSPSD PLELLGADTA 

        70         80         90        100        110        120 
ERRLLGSPSA WAVEFFASWC GHCIHFAPTW RALAEDVREW RPAVMIAALD CADEANQQVC 

       130        140        150        160        170        180 
ADFGITGFPT LKFFRAFSKK AEDGIRIAHP TATVADLRRA IITNLEQSGD AWPPACPPLE 

       190        200        210        220        230        240 
PASAEEVRSF FHRNTERYLA LIFEQSNSFV GREVALDLLQ YENVAVRRVL SSEEELVEKF 

       250        260        270        280        290        300 
GVTTFPSAYL LLRNGSFSRL PVHAEARSFY TYYLQTLSGV TRGSYRLNVT GSAINETRAL 

       310        320        330        340        350        360 
QPAQADRSKV YVADLESTVH YTLRVEAGRP AVLAGAQLAA LKCYVATLAK YFPGRPSVQT 

       370        380        390        400        410        420 
FLQSLDSWLR NWTEPELPRS ALKEAVKNKE DASPAAVLPT NVTWVGCRGS EPHFRGYPCG 

       430        440        450        460        470        480 
LWTIFHLLTV QAAQGGPDEE LPLEVLNTMR CYVKHFFGCQ ECAQHFEAMA AKSMDQVKSR 

       490        500        510        520        530        540 
REAVLWLWSH HNEVNARLAG GDTEDPQFPK LQWPPPDMCP QCHREERGVH TWDEAAVLSF 

       550        560        570        580        590        600 
LKEHFSLGNL YLDHAIPIPM AGEEAAASAR LSTAGLREKE EEERKEEEEE GEKETEKPHR 

       610        620        630        640        650        660 
EGETGRPGSS ELRRPSIVRR NPRLRALGED IVDLDSFSEQ HFKSKALRAA GRHRRLSKRD 

       670        680        690        700        710        720 
TVALHHDAGW ERLQVPESRE EEEEGGVLRR SPWLRVLGLG FSRLDVSLCI ALYFLSSMCL 

       730        740 
LGMYTFFRLR TRARKGRPGF PVA 

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References

[1]"Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes."
Thorpe C., Hoober K.L., Raje S., Glynn N.M., Burnside J., Turi G.K., Coppock D.L.
Arch. Biochem. Biophys. 405:1-12(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY112666 mRNA. Translation: AAM44079.1.
RefSeqNP_989456.1. NM_204125.1.
UniGeneGga.148.

3D structure databases

ProteinModelPortalQ8JGM4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000006256.

Proteomic databases

PRIDEQ8JGM4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID373914.
KEGGgga:373914.

Organism-specific databases

CTD5768.

Phylogenomic databases

eggNOGNOG237986.
HOGENOMHOG000231631.
HOVERGENHBG080360.
InParanoidQ8JGM4.
KOK10758.
PhylomeDBQ8JGM4.

Family and domain databases

Gene3D1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813446.
PROQ8JGM4.

Entry information

Entry nameQSOX1_CHICK
AccessionPrimary (citable) accession number: Q8JGM4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families