Reviewed, UniProtKB/Swiss-Prot Q8JGM4 (QSOX1_CHICK)

Names and origin

Protein names

Recommended name:
    Sulfhydryl oxidase 1
    EC=1.8.3.2
Alternative name(s):
    Quiescin Q6

Gene names

Name:	QSOX1
Synonyms:	QSCN6, QSOX, SOX

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	743 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.
Catalytic activity	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer. Ref.1
Subcellular location	Golgi apparatus membrane; Single-pass membrane protein By similarity.
Tissue specificity	Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells. Highly expressed in the active secretory tissue of the oviduct. Ref.1
Sequence similarities	Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Contains 1 ERV/ALR sulfhydryl oxidase domain. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal Transmembrane
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein thiol-disulfide exchange Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	flavin-linked sulfhydryl oxidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 42	42	Potential
	Chain	43 – 743	701	Sulfhydryl oxidase 1		PRO_0000249537
Regions
	Transmembrane	707 – 727	21	Potential
	Domain	43 – 166	124	Thioredoxin
	Domain	410 – 513	104	ERV/ALR sulfhydryl oxidase
	Compositional bias	578 – 603	26	Glu-rich
	Compositional bias	680 – 684	5	Poly-Glu
Amino acid modifications
	Glycosylation	254	1	N-linked (GlcNAc...) Potential
	Glycosylation	288	1	N-linked (GlcNAc...) Potential
	Glycosylation	295	1	N-linked (GlcNAc...) Potential
	Glycosylation	371	1	N-linked (GlcNAc...) Potential
	Glycosylation	401	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8JGM4-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 44512B7EBB0B9769	FASTA	743	83,079
	10 20 30 40 50 60 MWRRRARSGG GGGGGGGGAA PRCRWWPAVL ALLAAALPAA RSRSLYSPSD PLELLGADTA 70 80 90 100 110 120 ERRLLGSPSA WAVEFFASWC GHCIHFAPTW RALAEDVREW RPAVMIAALD CADEANQQVC 130 140 150 160 170 180 ADFGITGFPT LKFFRAFSKK AEDGIRIAHP TATVADLRRA IITNLEQSGD AWPPACPPLE 190 200 210 220 230 240 PASAEEVRSF FHRNTERYLA LIFEQSNSFV GREVALDLLQ YENVAVRRVL SSEEELVEKF 250 260 270 280 290 300 GVTTFPSAYL LLRNGSFSRL PVHAEARSFY TYYLQTLSGV TRGSYRLNVT GSAINETRAL 310 320 330 340 350 360 QPAQADRSKV YVADLESTVH YTLRVEAGRP AVLAGAQLAA LKCYVATLAK YFPGRPSVQT 370 380 390 400 410 420 FLQSLDSWLR NWTEPELPRS ALKEAVKNKE DASPAAVLPT NVTWVGCRGS EPHFRGYPCG 430 440 450 460 470 480 LWTIFHLLTV QAAQGGPDEE LPLEVLNTMR CYVKHFFGCQ ECAQHFEAMA AKSMDQVKSR 490 500 510 520 530 540 REAVLWLWSH HNEVNARLAG GDTEDPQFPK LQWPPPDMCP QCHREERGVH TWDEAAVLSF 550 560 570 580 590 600 LKEHFSLGNL YLDHAIPIPM AGEEAAASAR LSTAGLREKE EEERKEEEEE GEKETEKPHR 610 620 630 640 650 660 EGETGRPGSS ELRRPSIVRR NPRLRALGED IVDLDSFSEQ HFKSKALRAA GRHRRLSKRD 670 680 690 700 710 720 TVALHHDAGW ERLQVPESRE EEEEGGVLRR SPWLRVLGLG FSRLDVSLCI ALYFLSSMCL 730 740 LGMYTFFRLR TRARKGRPGF PVA

References

[1]

"Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes." Thorpe C., Hoober K.L., Raje S., Glynn N.M., Burnside J., Turi G.K., Coppock D.L. Arch. Biochem. Biophys. 405:1-12(2002) [PubMed: 12176051] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY112666 mRNA. Translation: AAM44079.1.
IPI	IPI00571581.
RefSeq	NP_989456.1.
UniGene	Gga.148
3D structure databases
HSSP	HSSP built from PDB template 1F9M based on UniProtKB P09856.
ModBase	Search...
Proteomic databases
PRIDE	Q8JGM4.
Genome annotation databases
Ensembl	ENSGALG00000003933. Gallus gallus. [Contig view]
GeneID	373914.
KEGG	gga:373914.
Phylogenomic databases
HOVERGEN	Q8JGM4.
Enzyme and pathway databases
BRENDA	1.8.3.2. 4.
Family and domain databases
InterPro	IPR010747. DUF1321. IPR017905. ERV/ALR_sulphydryl_oxidase. IPR006863. Evr1_Alr. IPR017936. Thioredoxin-like. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.120.310. Evr1_Alr. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF07031. DUF1321. 1 hit. PF04777. Evr1_Alr. 1 hit. PF00085. Thioredoxin. 1 hit. [Graphical view]
PROSITE	PS51324. ERV_ALR. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QSOX1_CHICK

Accession

Primary (citable) accession number: Q8JGM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)