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Q8JGM4

- QSOX1_CHICK

UniProt

Q8JGM4 - QSOX1_CHICK

Protein

Sulfhydryl oxidase 1

Gene

QSOX1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.By similarity

    Catalytic activityi

    2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801NucleophileBy similarity
    Active sitei83 – 831NucleophileBy similarity
    Binding sitei415 – 4151FADBy similarity
    Binding sitei422 – 4221FADBy similarity
    Binding sitei426 – 4261FADBy similarity
    Binding sitei461 – 4611FADBy similarity
    Binding sitei465 – 4651FADBy similarity
    Binding sitei510 – 5101FADBy similarity
    Binding sitei513 – 5131FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi488 – 4958FADBy similarity

    GO - Molecular functioni

    1. flavin-linked sulfhydryl oxidase activity Source: UniProtKB
    2. protein disulfide isomerase activity Source: UniProtKB

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfhydryl oxidase 1 (EC:1.8.3.2)
    Alternative name(s):
    Quiescin Q6
    Gene namesi
    Name:QSOX1
    Synonyms:QSCN6, QSOX, SOX
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB
    2. integral component of Golgi membrane Source: Ensembl

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4242Sequence AnalysisAdd
    BLAST
    Chaini43 – 743701Sulfhydryl oxidase 1PRO_0000249537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi80 ↔ 83Redox-activePROSITE-ProRule annotation
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi407 ↔ 419PROSITE-ProRule annotation
    Disulfide bondi459 ↔ 462PROSITE-ProRule annotation
    Disulfide bondi519 ↔ 522PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8JGM4.

    Expressioni

    Tissue specificityi

    Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells. Highly expressed in the active secretory tissue of the oviduct.1 Publication

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000006256.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JGM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei707 – 72721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 166124ThioredoxinPROSITE-ProRule annotationAdd
    BLAST
    Domaini410 – 513104ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi578 – 60326Glu-richAdd
    BLAST
    Compositional biasi680 – 6845Poly-Glu

    Sequence similaritiesi

    Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237986.
    HOGENOMiHOG000231631.
    HOVERGENiHBG080360.
    InParanoidiQ8JGM4.
    KOiK10758.
    PhylomeDBiQ8JGM4.

    Family and domain databases

    Gene3Di1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEiPS51324. ERV_ALR. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8JGM4-1 [UniParc]FASTAAdd to Basket

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    MWRRRARSGG GGGGGGGGAA PRCRWWPAVL ALLAAALPAA RSRSLYSPSD    50
    PLELLGADTA ERRLLGSPSA WAVEFFASWC GHCIHFAPTW RALAEDVREW 100
    RPAVMIAALD CADEANQQVC ADFGITGFPT LKFFRAFSKK AEDGIRIAHP 150
    TATVADLRRA IITNLEQSGD AWPPACPPLE PASAEEVRSF FHRNTERYLA 200
    LIFEQSNSFV GREVALDLLQ YENVAVRRVL SSEEELVEKF GVTTFPSAYL 250
    LLRNGSFSRL PVHAEARSFY TYYLQTLSGV TRGSYRLNVT GSAINETRAL 300
    QPAQADRSKV YVADLESTVH YTLRVEAGRP AVLAGAQLAA LKCYVATLAK 350
    YFPGRPSVQT FLQSLDSWLR NWTEPELPRS ALKEAVKNKE DASPAAVLPT 400
    NVTWVGCRGS EPHFRGYPCG LWTIFHLLTV QAAQGGPDEE LPLEVLNTMR 450
    CYVKHFFGCQ ECAQHFEAMA AKSMDQVKSR REAVLWLWSH HNEVNARLAG 500
    GDTEDPQFPK LQWPPPDMCP QCHREERGVH TWDEAAVLSF LKEHFSLGNL 550
    YLDHAIPIPM AGEEAAASAR LSTAGLREKE EEERKEEEEE GEKETEKPHR 600
    EGETGRPGSS ELRRPSIVRR NPRLRALGED IVDLDSFSEQ HFKSKALRAA 650
    GRHRRLSKRD TVALHHDAGW ERLQVPESRE EEEEGGVLRR SPWLRVLGLG 700
    FSRLDVSLCI ALYFLSSMCL LGMYTFFRLR TRARKGRPGF PVA 743
    Length:743
    Mass (Da):83,079
    Last modified:October 1, 2002 - v1
    Checksum:i44512B7EBB0B9769
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY112666 mRNA. Translation: AAM44079.1.
    RefSeqiNP_989456.1. NM_204125.1.
    UniGeneiGga.148.

    Genome annotation databases

    GeneIDi373914.
    KEGGigga:373914.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY112666 mRNA. Translation: AAM44079.1 .
    RefSeqi NP_989456.1. NM_204125.1.
    UniGenei Gga.148.

    3D structure databases

    ProteinModelPortali Q8JGM4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000006256.

    Proteomic databases

    PRIDEi Q8JGM4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 373914.
    KEGGi gga:373914.

    Organism-specific databases

    CTDi 5768.

    Phylogenomic databases

    eggNOGi NOG237986.
    HOGENOMi HOG000231631.
    HOVERGENi HBG080360.
    InParanoidi Q8JGM4.
    KOi K10758.
    PhylomeDBi Q8JGM4.

    Miscellaneous databases

    NextBioi 20813446.
    PROi Q8JGM4.

    Family and domain databases

    Gene3Di 1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEi PS51324. ERV_ALR. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes."
      Thorpe C., Hoober K.L., Raje S., Glynn N.M., Burnside J., Turi G.K., Coppock D.L.
      Arch. Biochem. Biophys. 405:1-12(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiQSOX1_CHICK
    AccessioniPrimary (citable) accession number: Q8JGM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3