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Protein

Repulsive guidance molecule A

Gene

RGMA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1502Cleavage; by autolysisBy similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Repulsive guidance molecule A
Gene namesi
Name:RGMA
Synonyms:RGM
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

  1. Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 149120Removed in mature formCuratedPRO_0000030391Add
BLAST
Chaini150 – 404255Repulsive guidance molecule APRO_0000030392Add
BLAST
Propeptidei405 – 43228Removed in mature formSequence AnalysisPRO_0000030393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi126 ↔ 207By similarity
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi144 ↔ 296By similarity
Lipidationi404 – 4041GPI-anchor amidated asparagineSequence Analysis

Post-translational modificationi

Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.By similarity

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8JG54.

Expressioni

Developmental stagei

Expressed in the periventricular layer surrounding the tectal ventricle (E9). Forms a spatial gradient with increasing concentration from the anterior to posterior pole of the embryonic optic tectum.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011271.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG87951.
HOGENOMiHOG000013072.
HOVERGENiHBG057627.
InParanoidiQ8JG54.
KOiK06847.
PhylomeDBiQ8JG54.

Family and domain databases

InterProiIPR009496. RGM_C.
IPR010536. RGM_N.
[Graphical view]
PfamiPF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JG54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRGAGSTAL GLFQILPVFL CIFPPVTSPC KILKCNSEFW AATSGSHHLG
60 70 80 90 100
AEETPEFCTA LRAYAHCTRR TARTCRGDLA YHSAVHGIDD LMVQHNCSKD
110 120 130 140 150
GPTSQPRLRT LPPGDSQERS DSPEICHYEK SFHKHSAAPN YTHCGLFGDP
160 170 180 190 200
HLRTFTDTFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSS ATATSKLTII
210 220 230 240 250
FKSFQECVEQ KVYQAEMDEL PAAFADGSKN GGDKHGANSL KITEKVSGQH
260 270 280 290 300
IEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC
310 320 330 340 350
PLNQQIDFQT FRLAQAAEGR ARRKGPSLPA PPEAFTYESA TAKCREKLPV
360 370 380 390 400
EDLYFQSCVF DLLTTGDVNF MLAAYYAFED VKMLHSNKDK LHLYERTRAL
410 420 430
APGNAAPSEH PWALPALWVA LLSLSQCWLG LL
Length:432
Mass (Da):47,775
Last modified:October 1, 2002 - v1
Checksum:i087ABAC6BA0A681D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128507 mRNA. Translation: AAM95449.1.
RefSeqiNP_989868.2. NM_204537.1.
UniGeneiGga.117.

Genome annotation databases

GeneIDi395214.
KEGGigga:395214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128507 mRNA. Translation: AAM95449.1.
RefSeqiNP_989868.2. NM_204537.1.
UniGeneiGga.117.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011271.

Proteomic databases

PaxDbiQ8JG54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395214.
KEGGigga:395214.

Organism-specific databases

CTDi56963.

Phylogenomic databases

eggNOGiNOG87951.
HOGENOMiHOG000013072.
HOVERGENiHBG057627.
InParanoidiQ8JG54.
KOiK06847.
PhylomeDBiQ8JG54.

Miscellaneous databases

NextBioi20815303.
PROiQ8JG54.

Family and domain databases

InterProiIPR009496. RGM_C.
IPR010536. RGM_N.
[Graphical view]
PfamiPF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic eye.

Entry informationi

Entry nameiRGMA_CHICK
AccessioniPrimary (citable) accession number: Q8JG54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.