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Q8JG54 (RGMA_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Repulsive guidance molecule A
Gene names
Name:RGMA
Synonyms:RGM
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor Ref.1.

Developmental stage

Expressed in the periventricular layer surrounding the tectal ventricle (E9). Forms a spatial gradient with increasing concentration from the anterior to posterior pole of the embryonic optic tectum.

Sequence similarities

Belongs to the repulsive guidance molecule (RGM) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 149120Removed in mature form Probable
PRO_0000030391
Chain150 – 404255Repulsive guidance molecule A
PRO_0000030392
Propeptide405 – 43228Removed in mature form Potential
PRO_0000030393

Amino acid modifications

Lipidation4041GPI-anchor amidated asparagine Potential
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8JG54 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 087ABAC6BA0A681D

FASTA43247,775
        10         20         30         40         50         60 
MGRGAGSTAL GLFQILPVFL CIFPPVTSPC KILKCNSEFW AATSGSHHLG AEETPEFCTA 

        70         80         90        100        110        120 
LRAYAHCTRR TARTCRGDLA YHSAVHGIDD LMVQHNCSKD GPTSQPRLRT LPPGDSQERS 

       130        140        150        160        170        180 
DSPEICHYEK SFHKHSAAPN YTHCGLFGDP HLRTFTDTFQ TCKVQGAWPL IDNNYLNVQV 

       190        200        210        220        230        240 
TNTPVLPGSS ATATSKLTII FKSFQECVEQ KVYQAEMDEL PAAFADGSKN GGDKHGANSL 

       250        260        270        280        290        300 
KITEKVSGQH IEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC 

       310        320        330        340        350        360 
PLNQQIDFQT FRLAQAAEGR ARRKGPSLPA PPEAFTYESA TAKCREKLPV EDLYFQSCVF 

       370        380        390        400        410        420 
DLLTTGDVNF MLAAYYAFED VKMLHSNKDK LHLYERTRAL APGNAAPSEH PWALPALWVA 

       430 
LLSLSQCWLG LL

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References

[1]"RGM is a repulsive guidance molecule for retinal axons."
Monnier P.P., Sierra A., Macchi P., Deitinghoff L., Andersen J.S., Mann M., Flad M., Hornberger M.R., Stahl B., Bonhoeffer F., Mueller B.K.
Nature 419:392-395(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
Tissue: Embryonic eye.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY128507 mRNA. Translation: AAM95449.1.
IPIIPI00595846.
RefSeqNP_989868.1. NM_204537.1.
UniGeneGga.117.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000011271.

Proteomic databases

PaxDbQ8JG54.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395214.
KEGGgga:395214.

Organism-specific databases

CTD56963.

Phylogenomic databases

eggNOGNOG87951.
HOGENOMHOG000013072.
HOVERGENHBG057627.
InParanoidQ8JG54.
KOK06847.
OrthoDBEOG4001JB.

Enzyme and pathway databases

ReactomeREACT_115433. Developmental Biology.

Family and domain databases

InterProIPR009496. RGM_C.
IPR010536. RGM_N.
[Graphical view]
PfamPF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815303.

Entry information

Entry nameRGMA_CHICK
AccessionPrimary (citable) accession number: Q8JG54
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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