Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8JG54

- RGMA_CHICK

UniProt

Q8JG54 - RGMA_CHICK

Protein

Repulsive guidance molecule A

Gene

RGMA

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei149 – 1502Cleavage; by autolysisBy similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Repulsive guidance molecule A
    Gene namesi
    Name:RGMA
    Synonyms:RGM
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 149120Removed in mature formCuratedPRO_0000030391Add
    BLAST
    Chaini150 – 404255Repulsive guidance molecule APRO_0000030392Add
    BLAST
    Propeptidei405 – 43228Removed in mature formSequence AnalysisPRO_0000030393Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi126 ↔ 207By similarity
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi144 ↔ 296By similarity
    Lipidationi404 – 4041GPI-anchor amidated asparagineSequence Analysis

    Post-translational modificationi

    Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.By similarity

    Keywords - PTMi

    Autocatalytic cleavage, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ8JG54.

    Expressioni

    Developmental stagei

    Expressed in the periventricular layer surrounding the tectal ventricle (E9). Forms a spatial gradient with increasing concentration from the anterior to posterior pole of the embryonic optic tectum.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000011271.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG87951.
    HOGENOMiHOG000013072.
    HOVERGENiHBG057627.
    InParanoidiQ8JG54.
    KOiK06847.
    PhylomeDBiQ8JG54.

    Family and domain databases

    InterProiIPR009496. RGM_C.
    IPR010536. RGM_N.
    [Graphical view]
    PfamiPF06534. RGM_C. 1 hit.
    PF06535. RGM_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8JG54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRGAGSTAL GLFQILPVFL CIFPPVTSPC KILKCNSEFW AATSGSHHLG    50
    AEETPEFCTA LRAYAHCTRR TARTCRGDLA YHSAVHGIDD LMVQHNCSKD 100
    GPTSQPRLRT LPPGDSQERS DSPEICHYEK SFHKHSAAPN YTHCGLFGDP 150
    HLRTFTDTFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSS ATATSKLTII 200
    FKSFQECVEQ KVYQAEMDEL PAAFADGSKN GGDKHGANSL KITEKVSGQH 250
    IEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC 300
    PLNQQIDFQT FRLAQAAEGR ARRKGPSLPA PPEAFTYESA TAKCREKLPV 350
    EDLYFQSCVF DLLTTGDVNF MLAAYYAFED VKMLHSNKDK LHLYERTRAL 400
    APGNAAPSEH PWALPALWVA LLSLSQCWLG LL 432
    Length:432
    Mass (Da):47,775
    Last modified:October 1, 2002 - v1
    Checksum:i087ABAC6BA0A681D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY128507 mRNA. Translation: AAM95449.1.
    RefSeqiNP_989868.1. NM_204537.1.
    UniGeneiGga.117.

    Genome annotation databases

    GeneIDi395214.
    KEGGigga:395214.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY128507 mRNA. Translation: AAM95449.1 .
    RefSeqi NP_989868.1. NM_204537.1.
    UniGenei Gga.117.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000011271.

    Proteomic databases

    PaxDbi Q8JG54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395214.
    KEGGi gga:395214.

    Organism-specific databases

    CTDi 56963.

    Phylogenomic databases

    eggNOGi NOG87951.
    HOGENOMi HOG000013072.
    HOVERGENi HBG057627.
    InParanoidi Q8JG54.
    KOi K06847.
    PhylomeDBi Q8JG54.

    Miscellaneous databases

    NextBioi 20815303.
    PROi Q8JG54.

    Family and domain databases

    InterProi IPR009496. RGM_C.
    IPR010536. RGM_N.
    [Graphical view ]
    Pfami PF06534. RGM_C. 1 hit.
    PF06535. RGM_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryonic eye.

    Entry informationi

    Entry nameiRGMA_CHICK
    AccessioniPrimary (citable) accession number: Q8JG54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3