Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8JG54

- RGMA_CHICK

UniProt

Q8JG54 - RGMA_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Repulsive guidance molecule A

Gene

RGMA

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1502Cleavage; by autolysisBy similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Repulsive guidance molecule A
Gene namesi
Name:RGMA
Synonyms:RGM
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 149120Removed in mature formCuratedPRO_0000030391Add
BLAST
Chaini150 – 404255Repulsive guidance molecule APRO_0000030392Add
BLAST
Propeptidei405 – 43228Removed in mature formSequence AnalysisPRO_0000030393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi126 ↔ 207By similarity
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi144 ↔ 296By similarity
Lipidationi404 – 4041GPI-anchor amidated asparagineSequence Analysis

Post-translational modificationi

Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.By similarity

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8JG54.

Expressioni

Developmental stagei

Expressed in the periventricular layer surrounding the tectal ventricle (E9). Forms a spatial gradient with increasing concentration from the anterior to posterior pole of the embryonic optic tectum.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011271.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG87951.
HOGENOMiHOG000013072.
HOVERGENiHBG057627.
InParanoidiQ8JG54.
KOiK06847.
PhylomeDBiQ8JG54.

Family and domain databases

InterProiIPR009496. RGM_C.
IPR010536. RGM_N.
[Graphical view]
PfamiPF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JG54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRGAGSTAL GLFQILPVFL CIFPPVTSPC KILKCNSEFW AATSGSHHLG
60 70 80 90 100
AEETPEFCTA LRAYAHCTRR TARTCRGDLA YHSAVHGIDD LMVQHNCSKD
110 120 130 140 150
GPTSQPRLRT LPPGDSQERS DSPEICHYEK SFHKHSAAPN YTHCGLFGDP
160 170 180 190 200
HLRTFTDTFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSS ATATSKLTII
210 220 230 240 250
FKSFQECVEQ KVYQAEMDEL PAAFADGSKN GGDKHGANSL KITEKVSGQH
260 270 280 290 300
IEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC
310 320 330 340 350
PLNQQIDFQT FRLAQAAEGR ARRKGPSLPA PPEAFTYESA TAKCREKLPV
360 370 380 390 400
EDLYFQSCVF DLLTTGDVNF MLAAYYAFED VKMLHSNKDK LHLYERTRAL
410 420 430
APGNAAPSEH PWALPALWVA LLSLSQCWLG LL
Length:432
Mass (Da):47,775
Last modified:October 1, 2002 - v1
Checksum:i087ABAC6BA0A681D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128507 mRNA. Translation: AAM95449.1.
RefSeqiNP_989868.1. NM_204537.1.
UniGeneiGga.117.

Genome annotation databases

GeneIDi395214.
KEGGigga:395214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128507 mRNA. Translation: AAM95449.1 .
RefSeqi NP_989868.1. NM_204537.1.
UniGenei Gga.117.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000011271.

Proteomic databases

PaxDbi Q8JG54.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395214.
KEGGi gga:395214.

Organism-specific databases

CTDi 56963.

Phylogenomic databases

eggNOGi NOG87951.
HOGENOMi HOG000013072.
HOVERGENi HBG057627.
InParanoidi Q8JG54.
KOi K06847.
PhylomeDBi Q8JG54.

Miscellaneous databases

NextBioi 20815303.
PROi Q8JG54.

Family and domain databases

InterProi IPR009496. RGM_C.
IPR010536. RGM_N.
[Graphical view ]
Pfami PF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic eye.

Entry informationi

Entry nameiRGMA_CHICK
AccessioniPrimary (citable) accession number: Q8JG54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3