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Protein

Repulsive guidance molecule A

Gene

RGMA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Repulsive guidance molecule A
Gene namesi
Name:RGMA
Synonyms:RGM
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000003039130 – 149Removed in mature formCuratedAdd BLAST120
ChainiPRO_0000030392150 – 404Repulsive guidance molecule AAdd BLAST255
PropeptideiPRO_0000030393405 – 432Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi126 ↔ 207By similarity
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 296By similarity
Lipidationi404GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei149 – 150Cleavage; by autolysisBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8JG54.

Expressioni

Developmental stagei

Expressed in the periventricular layer surrounding the tectal ventricle (E9). Forms a spatial gradient with increasing concentration from the anterior to posterior pole of the embryonic optic tectum.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011271.

Structurei

3D structure databases

ProteinModelPortaliQ8JG54.
SMRiQ8JG54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFAH. Eukaryota.
ENOG410ZT7E. LUCA.
HOGENOMiHOG000013072.
HOVERGENiHBG057627.
InParanoidiQ8JG54.
KOiK06847.
PhylomeDBiQ8JG54.

Family and domain databases

InterProiIPR009496. RGM_C.
IPR010536. RGM_N.
IPR033607. RGMA.
[Graphical view]
PANTHERiPTHR31428:SF4. PTHR31428:SF4. 1 hit.
PfamiPF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JG54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRGAGSTAL GLFQILPVFL CIFPPVTSPC KILKCNSEFW AATSGSHHLG
60 70 80 90 100
AEETPEFCTA LRAYAHCTRR TARTCRGDLA YHSAVHGIDD LMVQHNCSKD
110 120 130 140 150
GPTSQPRLRT LPPGDSQERS DSPEICHYEK SFHKHSAAPN YTHCGLFGDP
160 170 180 190 200
HLRTFTDTFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSS ATATSKLTII
210 220 230 240 250
FKSFQECVEQ KVYQAEMDEL PAAFADGSKN GGDKHGANSL KITEKVSGQH
260 270 280 290 300
IEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC
310 320 330 340 350
PLNQQIDFQT FRLAQAAEGR ARRKGPSLPA PPEAFTYESA TAKCREKLPV
360 370 380 390 400
EDLYFQSCVF DLLTTGDVNF MLAAYYAFED VKMLHSNKDK LHLYERTRAL
410 420 430
APGNAAPSEH PWALPALWVA LLSLSQCWLG LL
Length:432
Mass (Da):47,775
Last modified:October 1, 2002 - v1
Checksum:i087ABAC6BA0A681D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128507 mRNA. Translation: AAM95449.1.
RefSeqiNP_989868.2. NM_204537.1.
UniGeneiGga.117.

Genome annotation databases

GeneIDi395214.
KEGGigga:395214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128507 mRNA. Translation: AAM95449.1.
RefSeqiNP_989868.2. NM_204537.1.
UniGeneiGga.117.

3D structure databases

ProteinModelPortaliQ8JG54.
SMRiQ8JG54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011271.

Proteomic databases

PaxDbiQ8JG54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395214.
KEGGigga:395214.

Organism-specific databases

CTDi56963.

Phylogenomic databases

eggNOGiENOG410IFAH. Eukaryota.
ENOG410ZT7E. LUCA.
HOGENOMiHOG000013072.
HOVERGENiHBG057627.
InParanoidiQ8JG54.
KOiK06847.
PhylomeDBiQ8JG54.

Miscellaneous databases

PROiQ8JG54.

Family and domain databases

InterProiIPR009496. RGM_C.
IPR010536. RGM_N.
IPR033607. RGMA.
[Graphical view]
PANTHERiPTHR31428:SF4. PTHR31428:SF4. 1 hit.
PfamiPF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGMA_CHICK
AccessioniPrimary (citable) accession number: Q8JG54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.