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Q8JG54

- RGMA_CHICK

UniProt

Q8JG54 - RGMA_CHICK

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Protein
Repulsive guidance molecule A
Gene
RGMA, RGM
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1502Cleavage; by autolysis By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Repulsive guidance molecule A
Gene namesi
Name:RGMA
Synonyms:RGM
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Propeptidei30 – 149120Removed in mature form Inferred
PRO_0000030391Add
BLAST
Chaini150 – 404255Repulsive guidance molecule A
PRO_0000030392Add
BLAST
Propeptidei405 – 43228Removed in mature form Reviewed prediction
PRO_0000030393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi126 ↔ 207 By similarity
Glycosylationi140 – 1401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi144 ↔ 296 By similarity
Lipidationi404 – 4041GPI-anchor amidated asparagine Reviewed prediction

Post-translational modificationi

Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds By similarity.

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8JG54.

Expressioni

Developmental stagei

Expressed in the periventricular layer surrounding the tectal ventricle (E9). Forms a spatial gradient with increasing concentration from the anterior to posterior pole of the embryonic optic tectum.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011271.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG87951.
HOGENOMiHOG000013072.
HOVERGENiHBG057627.
InParanoidiQ8JG54.
KOiK06847.
PhylomeDBiQ8JG54.

Family and domain databases

InterProiIPR009496. RGM_C.
IPR010536. RGM_N.
[Graphical view]
PfamiPF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JG54-1 [UniParc]FASTAAdd to Basket

« Hide

MGRGAGSTAL GLFQILPVFL CIFPPVTSPC KILKCNSEFW AATSGSHHLG    50
AEETPEFCTA LRAYAHCTRR TARTCRGDLA YHSAVHGIDD LMVQHNCSKD 100
GPTSQPRLRT LPPGDSQERS DSPEICHYEK SFHKHSAAPN YTHCGLFGDP 150
HLRTFTDTFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSS ATATSKLTII 200
FKSFQECVEQ KVYQAEMDEL PAAFADGSKN GGDKHGANSL KITEKVSGQH 250
IEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC 300
PLNQQIDFQT FRLAQAAEGR ARRKGPSLPA PPEAFTYESA TAKCREKLPV 350
EDLYFQSCVF DLLTTGDVNF MLAAYYAFED VKMLHSNKDK LHLYERTRAL 400
APGNAAPSEH PWALPALWVA LLSLSQCWLG LL 432
Length:432
Mass (Da):47,775
Last modified:October 1, 2002 - v1
Checksum:i087ABAC6BA0A681D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY128507 mRNA. Translation: AAM95449.1.
RefSeqiNP_989868.1. NM_204537.1.
UniGeneiGga.117.

Genome annotation databases

GeneIDi395214.
KEGGigga:395214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY128507 mRNA. Translation: AAM95449.1 .
RefSeqi NP_989868.1. NM_204537.1.
UniGenei Gga.117.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000011271.

Proteomic databases

PaxDbi Q8JG54.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395214.
KEGGi gga:395214.

Organism-specific databases

CTDi 56963.

Phylogenomic databases

eggNOGi NOG87951.
HOGENOMi HOG000013072.
HOVERGENi HBG057627.
InParanoidi Q8JG54.
KOi K06847.
PhylomeDBi Q8JG54.

Miscellaneous databases

NextBioi 20815303.
PROi Q8JG54.

Family and domain databases

InterProi IPR009496. RGM_C.
IPR010536. RGM_N.
[Graphical view ]
Pfami PF06534. RGM_C. 1 hit.
PF06535. RGM_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic eye.

Entry informationi

Entry nameiRGMA_CHICK
AccessioniPrimary (citable) accession number: Q8JG54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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