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Q8J308

- ALF1_THEKO

UniProt

Q8J308 - ALF1_THEKO

Protein

Fructose-bisphosphate aldolase class 1

Gene

fba

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Enzyme regulationi

    Activated by citrate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei191 – 1911Schiff-base intermediate with dihydroxyacetone-PBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciTKOD69014:GH72-1002-MONOMER.
    SABIO-RKQ8J308.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
    Alternative name(s):
    Fructose-bisphosphate aldolase class I
    Short name:
    FBP aldolase
    Tk-fba
    Gene namesi
    Name:fba
    Ordered Locus Names:TK0989
    OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
    Taxonomic identifieri69014 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000000536: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281Fructose-bisphosphate aldolase class 1PRO_0000138951Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    STRINGi69014.TK0989.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8J308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DeoC/FbaB aldolase family.Curated

    Phylogenomic databases

    eggNOGiCOG1830.
    HOGENOMiHOG000224790.
    KOiK11645.
    OMAiEWKMFEE.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view]
    PfamiPF01791. DeoC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8J308-1 [UniParc]FASTAAdd to Basket

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    MDAYQSVGIR RRLKRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPRI    50
    IIRKVVRAGV DGVMMLPGIV RMAGDELKPD TGLMIKLTSK TELRPKEEQL 100
    LQSQLGYVED AIKLGADAIA ATVYWGSPQE DVMMRQFAEI ASYAHDLGFP 150
    VVQFAYPRGP YINEKYGKKE DYRVVMYGAR AAAETGADMI KTYWTGSKET 200
    FAKVVDAAAG VPVLLSGGAK TDNPVDFLKV VWDVIEAGGA GAVVGRNIFQ 250
    RENPEPMIKA LIRVIHRNED PEEAAKAEGL I 281
    Length:281
    Mass (Da):31,240
    Last modified:March 1, 2003 - v1
    Checksum:i9A95B90F50324B79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083709 Genomic DNA. Translation: BAC21177.1.
    AP006878 Genomic DNA. Translation: BAD85178.1.
    RefSeqiYP_183402.1. NC_006624.1.

    Genome annotation databases

    EnsemblBacteriaiBAD85178; BAD85178; TK0989.
    GeneIDi3233691.
    KEGGitko:TK0989.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083709 Genomic DNA. Translation: BAC21177.1 .
    AP006878 Genomic DNA. Translation: BAD85178.1 .
    RefSeqi YP_183402.1. NC_006624.1.

    3D structure databases

    ProteinModelPortali Q8J308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 69014.TK0989.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD85178 ; BAD85178 ; TK0989 .
    GeneIDi 3233691.
    KEGGi tko:TK0989.

    Phylogenomic databases

    eggNOGi COG1830.
    HOGENOMi HOG000224790.
    KOi K11645.
    OMAi EWKMFEE.

    Enzyme and pathway databases

    BioCyci TKOD69014:GH72-1002-MONOMER.
    SABIO-RK Q8J308.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view ]
    Pfami PF01791. DeoC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038992. Aldolase_Ia. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Fructose-1,6-bisphosphate aldolase from Thermococcus kodakaraensis KOD1."
      Imanaka H., Fukui T., Atomi H., Imanaka T.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.
    2. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
      Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
      Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-918 / JCM 12380 / KOD1.

    Entry informationi

    Entry nameiALF1_THEKO
    AccessioniPrimary (citable) accession number: Q8J308
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3