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Protein

Fructose-bisphosphate aldolase class 1

Gene

fba

Organism
Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme regulationi

Activated by citrate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei191 – 1911Schiff-base intermediate with dihydroxyacetone-PBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciTKOD69014:GH72-1002-MONOMER.
SABIO-RKQ8J308.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Tk-fba
Gene namesi
Name:fba
Ordered Locus Names:TK0989
OrganismiThermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Taxonomic identifieri69014 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000000536 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Fructose-bisphosphate aldolase class 1PRO_0000138951Add
BLAST

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi69014.TK0989.

Structurei

3D structure databases

ProteinModelPortaliQ8J308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family.Curated

Phylogenomic databases

eggNOGiCOG1830.
HOGENOMiHOG000224790.
InParanoidiQ8J308.
KOiK11645.
OMAiRVIHRNE.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8J308-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAYQSVGIR RRLKRFFRRD GRALIFAMDH GFEHGPTDFE PVWEHVNPRI
60 70 80 90 100
IIRKVVRAGV DGVMMLPGIV RMAGDELKPD TGLMIKLTSK TELRPKEEQL
110 120 130 140 150
LQSQLGYVED AIKLGADAIA ATVYWGSPQE DVMMRQFAEI ASYAHDLGFP
160 170 180 190 200
VVQFAYPRGP YINEKYGKKE DYRVVMYGAR AAAETGADMI KTYWTGSKET
210 220 230 240 250
FAKVVDAAAG VPVLLSGGAK TDNPVDFLKV VWDVIEAGGA GAVVGRNIFQ
260 270 280
RENPEPMIKA LIRVIHRNED PEEAAKAEGL I
Length:281
Mass (Da):31,240
Last modified:March 1, 2003 - v1
Checksum:i9A95B90F50324B79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083709 Genomic DNA. Translation: BAC21177.1.
AP006878 Genomic DNA. Translation: BAD85178.1.
RefSeqiYP_183402.1. NC_006624.1.

Genome annotation databases

EnsemblBacteriaiBAD85178; BAD85178; TK0989.
GeneIDi3233691.
KEGGitko:TK0989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083709 Genomic DNA. Translation: BAC21177.1.
AP006878 Genomic DNA. Translation: BAD85178.1.
RefSeqiYP_183402.1. NC_006624.1.

3D structure databases

ProteinModelPortaliQ8J308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi69014.TK0989.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD85178; BAD85178; TK0989.
GeneIDi3233691.
KEGGitko:TK0989.

Phylogenomic databases

eggNOGiCOG1830.
HOGENOMiHOG000224790.
InParanoidiQ8J308.
KOiK11645.
OMAiRVIHRNE.

Enzyme and pathway databases

BioCyciTKOD69014:GH72-1002-MONOMER.
SABIO-RKQ8J308.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF038992. Aldolase_Ia. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fructose-1,6-bisphosphate aldolase from Thermococcus kodakaraensis KOD1."
    Imanaka H., Fukui T., Atomi H., Imanaka T.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.
  2. "Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes."
    Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.
    Genome Res. 15:352-363(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Entry informationi

Entry nameiALF1_THEKO
AccessioniPrimary (citable) accession number: Q8J308
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.