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Q8J130

- TYRO_ASPFU

UniProt

Q8J130 - TYRO_ASPFU

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Protein

Tyrosinase

Gene

tyr1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.By similarity

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Copper ABy similarity
Metal bindingi92 – 921Copper ABy similarity
Metal bindingi101 – 1011Copper ABy similarity
Metal bindingi317 – 3171Copper BBy similarity
Metal bindingi321 – 3211Copper BBy similarity
Metal bindingi360 – 3601Copper BBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:tyr1
ORF Names:AFUA_1G17430
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630TyrosinasePRO_0000186732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki90 ↔ 922'-(S-cysteinyl)-histidine (Cys-His)By similarity

Keywords - PTMi

Thioether bond

Structurei

3D structure databases

ProteinModelPortaliQ8J130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Phylogenomic databases

eggNOGiNOG68512.
HOGENOMiHOG000217020.
InParanoidiQ8J130.
KOiK00505.
OrthoDBiEOG754HZ1.

Family and domain databases

Gene3Di1.10.1280.10. 2 hits.
InterProiIPR016216. Monophenol_mOase_fun.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000340. MPO_fungal. 1 hit.
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 2 hits.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8J130-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSNKPYVIK GIPVDAGQII PVRRDIDEWY EDTSRQSRIQ LSIFIWALRE
60 70 80 90 100
FQSIDYKDRL SYFQIAGIHH FPLITWDEEE PPVPNKPGYC VHNNVTFPTW
110 120 130 140 150
HRPYMLLFEQ RLFEIMETTI KETVPESHKQ EWRDAARQWR LPYWDFAKTS
160 170 180 190 200
GPHATGPLSL PVLCGLANVV ILNPANPETP IELPNPVYKY RAPDLMGNLD
210 220 230 240 250
KPFHIPPERI DPDKDDYYPW DKCQATTKYG LLKNNPHIQD AGQDVTKSNL
260 270 280 290 300
ALNEHPWYRP NKAGFPPLQT LTYEVHRLLS FKFSSWGAFA STKWCNEENK
310 320 330 340 350
PPASQQTRDI LSLEYIHNNV HNWVGGTDYL GDPSKPDLQG AGHMSSVPVA
360 370 380 390 400
AFDPIFWLYH NNVDRLTAIW QVLNQDHWFD EPHPSDAKPD DPLKPFHVSK
410 420 430 440 450
DKYFTSDDAR FWRKYGYDYD IVKKPGTNED RAPEEVKMKI NQLYGEPISR
460 470 480 490 500
LHEGQPVEYD YVINVIYDRY ALDGIPYTIV FYLHLKDGSY KCLGGVYTFS
510 520 530 540 550
TKLSDAQDTE RGGCDNCREQ KKAGVLASAQ IPLTYTLYER QEWHNLGKLL
560 570 580 590 600
PVKETADIIR QHLCWKVVGV NNSILFDSEQ PMRGDPATWR SLDVTAAYSE
610 620 630
IHYPVDRNYK YIDRGLPAYH NYLPIHLSPT
Length:630
Mass (Da):73,032
Last modified:January 10, 2006 - v2
Checksum:i11A769BD9737BF35
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti322 – 33514Missing in EAL91072. (PubMed:16372009)CuratedAdd
BLAST
Sequence conflicti600 – 6001E → D in CAC82195. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293806 Genomic DNA. Translation: CAC82195.1.
AAHF01000004 Genomic DNA. Translation: EAL91072.1.
RefSeqiXP_753110.1. XM_748017.1.

Genome annotation databases

GeneIDi3510142.
KEGGiafm:AFUA_1G17430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293806 Genomic DNA. Translation: CAC82195.1 .
AAHF01000004 Genomic DNA. Translation: EAL91072.1 .
RefSeqi XP_753110.1. XM_748017.1.

3D structure databases

ProteinModelPortali Q8J130.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3510142.
KEGGi afm:AFUA_1G17430.

Phylogenomic databases

eggNOGi NOG68512.
HOGENOMi HOG000217020.
InParanoidi Q8J130.
KOi K00505.
OrthoDBi EOG754HZ1.

Family and domain databases

Gene3Di 1.10.1280.10. 2 hits.
InterProi IPR016216. Monophenol_mOase_fun.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000340. MPO_fungal. 1 hit.
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 2 hits.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a tyrosinase gene of the human pathogenic fungus Aspergillus fumigatus."
    Langfelder K., Glaser P., Brakhage A.A.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 46645 / NCPF 2109.
  2. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiTYRO_ASPFU
AccessioniPrimary (citable) accession number: Q8J130
Secondary accession number(s): Q4WR60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 26, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3