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Q8J130

- TYRO_ASPFU

UniProt

Q8J130 - TYRO_ASPFU

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Protein

Tyrosinase

Gene
tyr1, AFUA_1G17430
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds By similarity.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Binds 2 copper ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Copper A By similarity
Metal bindingi92 – 921Copper A By similarity
Metal bindingi101 – 1011Copper A By similarity
Metal bindingi317 – 3171Copper B By similarity
Metal bindingi321 – 3211Copper B By similarity
Metal bindingi360 – 3601Copper B By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:tyr1
ORF Names:AFUA_1G17430
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630TyrosinasePRO_0000186732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki90 ↔ 922'-(S-cysteinyl)-histidine (Cys-His) By similarity

Keywords - PTMi

Thioether bond

Structurei

3D structure databases

ProteinModelPortaliQ8J130.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Phylogenomic databases

eggNOGiNOG68512.
HOGENOMiHOG000217020.
KOiK00505.
OrthoDBiEOG754HZ1.

Family and domain databases

Gene3Di1.10.1280.10. 2 hits.
InterProiIPR016216. Monophenol_mOase_fun.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000340. MPO_fungal. 1 hit.
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 2 hits.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8J130-1 [UniParc]FASTAAdd to Basket

« Hide

MSSNKPYVIK GIPVDAGQII PVRRDIDEWY EDTSRQSRIQ LSIFIWALRE    50
FQSIDYKDRL SYFQIAGIHH FPLITWDEEE PPVPNKPGYC VHNNVTFPTW 100
HRPYMLLFEQ RLFEIMETTI KETVPESHKQ EWRDAARQWR LPYWDFAKTS 150
GPHATGPLSL PVLCGLANVV ILNPANPETP IELPNPVYKY RAPDLMGNLD 200
KPFHIPPERI DPDKDDYYPW DKCQATTKYG LLKNNPHIQD AGQDVTKSNL 250
ALNEHPWYRP NKAGFPPLQT LTYEVHRLLS FKFSSWGAFA STKWCNEENK 300
PPASQQTRDI LSLEYIHNNV HNWVGGTDYL GDPSKPDLQG AGHMSSVPVA 350
AFDPIFWLYH NNVDRLTAIW QVLNQDHWFD EPHPSDAKPD DPLKPFHVSK 400
DKYFTSDDAR FWRKYGYDYD IVKKPGTNED RAPEEVKMKI NQLYGEPISR 450
LHEGQPVEYD YVINVIYDRY ALDGIPYTIV FYLHLKDGSY KCLGGVYTFS 500
TKLSDAQDTE RGGCDNCREQ KKAGVLASAQ IPLTYTLYER QEWHNLGKLL 550
PVKETADIIR QHLCWKVVGV NNSILFDSEQ PMRGDPATWR SLDVTAAYSE 600
IHYPVDRNYK YIDRGLPAYH NYLPIHLSPT 630
Length:630
Mass (Da):73,032
Last modified:January 10, 2006 - v2
Checksum:i11A769BD9737BF35
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti322 – 33514Missing in EAL91072. 1 PublicationAdd
BLAST
Sequence conflicti600 – 6001E → D in CAC82195. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293806 Genomic DNA. Translation: CAC82195.1.
AAHF01000004 Genomic DNA. Translation: EAL91072.1.
RefSeqiXP_753110.1. XM_748017.1.

Genome annotation databases

GeneIDi3510142.
KEGGiafm:AFUA_1G17430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293806 Genomic DNA. Translation: CAC82195.1 .
AAHF01000004 Genomic DNA. Translation: EAL91072.1 .
RefSeqi XP_753110.1. XM_748017.1.

3D structure databases

ProteinModelPortali Q8J130.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3510142.
KEGGi afm:AFUA_1G17430.

Phylogenomic databases

eggNOGi NOG68512.
HOGENOMi HOG000217020.
KOi K00505.
OrthoDBi EOG754HZ1.

Family and domain databases

Gene3Di 1.10.1280.10. 2 hits.
InterProi IPR016216. Monophenol_mOase_fun.
IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000340. MPO_fungal. 1 hit.
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 2 hits.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a tyrosinase gene of the human pathogenic fungus Aspergillus fumigatus."
    Langfelder K., Glaser P., Brakhage A.A.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 46645 / NCPF 2109.
  2. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiTYRO_ASPFU
AccessioniPrimary (citable) accession number: Q8J130
Secondary accession number(s): Q4WR60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: June 11, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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