SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8J0Q0

- MNS1_CANAX

UniProt

Q8J0Q0 - MNS1_CANAX

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mannosyl-oligosaccharide 1,2-alpha-mannosidase
Gene
MNS1
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the maturation of Asn-linked oligosaccharides. Trim a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2 By similarity.

Catalytic activityi

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

Cofactori

Calcium By similarity.

Pathwayi

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Calcium

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGH47. Glycoside Hydrolase Family 47.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC:3.2.1.113)
Alternative name(s):
Man(9)-alpha-mannosidase
Gene namesi
Name:MNS1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Mannosyl-oligosaccharide 1,2-alpha-mannosidase
PRO_0000210318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi320 ↔ 363 By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ8J0Q0.
SMRiQ8J0Q0. Positions 38-520.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG300315.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8J0Q0-1 [UniParc]FASTAAdd to Basket

« Hide

MLLKGFMLSL VLYAVYHLAS NGGQFMFDFS GQSKWERAQS EVRQAILDSW    50
HTYEKYGWGY DVYHPIKQEG ENMGPKPLGW MIVDSLDTLM IMDCPEEVSR 100
ARDWIKNDLD YTFDYNVNTF ETTIRMLGGL LSAYHFSNDD VYLDKAVQLA 150
NALHGAYDSP SGIPYSSVNL KSGKGIKNHV DNGASSTAEA ATVQLEMKYL 200
SKLTGEILWW NLAEKVMQVL ESNKPQDGLV PIYVNPDTGK YQGHLIRLGS 250
RGDSYYEYLL KQYLQTNKQE LVYWDMYRES VEGVKKHLVS DSYPSGLTFI 300
GELDNGIGGK LSTKMDHLVC FYGGLLALGA TGGLTLNEAQ SLKSWNEERE 350
ADFKLGEELT YTCYKMYHDV SPTGLSPEIV VFNEDTSKSK DFIIKPLDRH 400
NLQRPETVES LFYLYRLTGD VKYREMGYEI FQNFIKYTKV VNSEGEVSFS 450
SLSDVTSFDS NGLPKFKDNT ESFWWAETLK YLYLLFDDTN KIPLTDYVFN 500
TEAHPFPRFD TNDYFKTGWR RKIDENEKAQ MRESKVIDKS NLPEAQPVDK 550
SADQEAKEII EEIAG 565
Length:565
Mass (Da):64,659
Last modified:October 1, 2003 - v2
Checksum:iC3581A0D889CCAF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167027 Genomic DNA. Translation: AAN86059.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167027 Genomic DNA. Translation: AAN86059.2 .

3D structure databases

ProteinModelPortali Q8J0Q0.
SMRi Q8J0Q0. Positions 38-520.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH47. Glycoside Hydrolase Family 47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG300315.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

Gene3Di 1.50.10.50. 1 hit.
InterProi IPR001382. Glyco_hydro_47.
[Graphical view ]
PANTHERi PTHR11742. PTHR11742. 1 hit.
Pfami PF01532. Glyco_hydro_47. 1 hit.
[Graphical view ]
PRINTSi PR00747. GLYHDRLASE47.
SUPFAMi SSF48225. SSF48225. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of the alpha1,2-mannosidase gene (Mns1) in Candida albicans."
    Mora-Montes H.M., Flores-Carreon A., Ponce-Noyola P., Lopez-Romero E., Zinker-Ruzal S.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26555.

Entry informationi

Entry nameiMNS1_CANAX
AccessioniPrimary (citable) accession number: Q8J0Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2003
Last modified: October 16, 2013
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi