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Q8J0Q0

- MNS1_CANAX

UniProt

Q8J0Q0 - MNS1_CANAX

Protein

Mannosyl-oligosaccharide 1,2-alpha-mannosidase

Gene

MNS1

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Involved in the maturation of Asn-linked oligosaccharides. Trim a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2 By similarity.By similarity

    Catalytic activityi

    Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

    Cofactori

    Calcium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGH47. Glycoside Hydrolase Family 47.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC:3.2.1.113)
    Alternative name(s):
    Man(9)-alpha-mannosidase
    Gene namesi
    Name:MNS1
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Mannosyl-oligosaccharide 1,2-alpha-mannosidasePRO_0000210318Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi320 ↔ 363By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ8J0Q0.
    SMRiQ8J0Q0. Positions 38-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 47 family.Curated

    Phylogenomic databases

    eggNOGiNOG300315.

    Family and domain databases

    Gene3Di1.50.10.50. 1 hit.
    InterProiIPR001382. Glyco_hydro_47.
    [Graphical view]
    PANTHERiPTHR11742. PTHR11742. 1 hit.
    PfamiPF01532. Glyco_hydro_47. 1 hit.
    [Graphical view]
    PRINTSiPR00747. GLYHDRLASE47.
    SUPFAMiSSF48225. SSF48225. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8J0Q0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLKGFMLSL VLYAVYHLAS NGGQFMFDFS GQSKWERAQS EVRQAILDSW    50
    HTYEKYGWGY DVYHPIKQEG ENMGPKPLGW MIVDSLDTLM IMDCPEEVSR 100
    ARDWIKNDLD YTFDYNVNTF ETTIRMLGGL LSAYHFSNDD VYLDKAVQLA 150
    NALHGAYDSP SGIPYSSVNL KSGKGIKNHV DNGASSTAEA ATVQLEMKYL 200
    SKLTGEILWW NLAEKVMQVL ESNKPQDGLV PIYVNPDTGK YQGHLIRLGS 250
    RGDSYYEYLL KQYLQTNKQE LVYWDMYRES VEGVKKHLVS DSYPSGLTFI 300
    GELDNGIGGK LSTKMDHLVC FYGGLLALGA TGGLTLNEAQ SLKSWNEERE 350
    ADFKLGEELT YTCYKMYHDV SPTGLSPEIV VFNEDTSKSK DFIIKPLDRH 400
    NLQRPETVES LFYLYRLTGD VKYREMGYEI FQNFIKYTKV VNSEGEVSFS 450
    SLSDVTSFDS NGLPKFKDNT ESFWWAETLK YLYLLFDDTN KIPLTDYVFN 500
    TEAHPFPRFD TNDYFKTGWR RKIDENEKAQ MRESKVIDKS NLPEAQPVDK 550
    SADQEAKEII EEIAG 565
    Length:565
    Mass (Da):64,659
    Last modified:October 1, 2003 - v2
    Checksum:iC3581A0D889CCAF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY167027 Genomic DNA. Translation: AAN86059.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY167027 Genomic DNA. Translation: AAN86059.2 .

    3D structure databases

    ProteinModelPortali Q8J0Q0.
    SMRi Q8J0Q0. Positions 38-520.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH47. Glycoside Hydrolase Family 47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG300315.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    Gene3Di 1.50.10.50. 1 hit.
    InterProi IPR001382. Glyco_hydro_47.
    [Graphical view ]
    PANTHERi PTHR11742. PTHR11742. 1 hit.
    Pfami PF01532. Glyco_hydro_47. 1 hit.
    [Graphical view ]
    PRINTSi PR00747. GLYHDRLASE47.
    SUPFAMi SSF48225. SSF48225. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the alpha1,2-mannosidase gene (Mns1) in Candida albicans."
      Mora-Montes H.M., Flores-Carreon A., Ponce-Noyola P., Lopez-Romero E., Zinker-Ruzal S.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 26555.

    Entry informationi

    Entry nameiMNS1_CANAX
    AccessioniPrimary (citable) accession number: Q8J0Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3