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Q8J0Q0

- MNS1_CANAX

UniProt

Q8J0Q0 - MNS1_CANAX

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Protein

Mannosyl-oligosaccharide 1,2-alpha-mannosidase

Gene

MNS1

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in the maturation of Asn-linked oligosaccharides. Trim a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2 (By similarity).By similarity

Catalytic activityi

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

Cofactori

Calcium.By similarity

Pathwayi

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Calcium

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGH47. Glycoside Hydrolase Family 47.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC:3.2.1.113)
Alternative name(s):
Man(9)-alpha-mannosidase
Gene namesi
Name:MNS1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Mannosyl-oligosaccharide 1,2-alpha-mannosidasePRO_0000210318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi320 ↔ 363By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ8J0Q0.
SMRiQ8J0Q0. Positions 38-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.Curated

Phylogenomic databases

eggNOGiNOG300315.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8J0Q0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLKGFMLSL VLYAVYHLAS NGGQFMFDFS GQSKWERAQS EVRQAILDSW
60 70 80 90 100
HTYEKYGWGY DVYHPIKQEG ENMGPKPLGW MIVDSLDTLM IMDCPEEVSR
110 120 130 140 150
ARDWIKNDLD YTFDYNVNTF ETTIRMLGGL LSAYHFSNDD VYLDKAVQLA
160 170 180 190 200
NALHGAYDSP SGIPYSSVNL KSGKGIKNHV DNGASSTAEA ATVQLEMKYL
210 220 230 240 250
SKLTGEILWW NLAEKVMQVL ESNKPQDGLV PIYVNPDTGK YQGHLIRLGS
260 270 280 290 300
RGDSYYEYLL KQYLQTNKQE LVYWDMYRES VEGVKKHLVS DSYPSGLTFI
310 320 330 340 350
GELDNGIGGK LSTKMDHLVC FYGGLLALGA TGGLTLNEAQ SLKSWNEERE
360 370 380 390 400
ADFKLGEELT YTCYKMYHDV SPTGLSPEIV VFNEDTSKSK DFIIKPLDRH
410 420 430 440 450
NLQRPETVES LFYLYRLTGD VKYREMGYEI FQNFIKYTKV VNSEGEVSFS
460 470 480 490 500
SLSDVTSFDS NGLPKFKDNT ESFWWAETLK YLYLLFDDTN KIPLTDYVFN
510 520 530 540 550
TEAHPFPRFD TNDYFKTGWR RKIDENEKAQ MRESKVIDKS NLPEAQPVDK
560
SADQEAKEII EEIAG
Length:565
Mass (Da):64,659
Last modified:October 1, 2003 - v2
Checksum:iC3581A0D889CCAF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167027 Genomic DNA. Translation: AAN86059.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167027 Genomic DNA. Translation: AAN86059.2 .

3D structure databases

ProteinModelPortali Q8J0Q0.
SMRi Q8J0Q0. Positions 38-520.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH47. Glycoside Hydrolase Family 47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG300315.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

Gene3Di 1.50.10.50. 1 hit.
InterProi IPR001382. Glyco_hydro_47.
[Graphical view ]
PANTHERi PTHR11742. PTHR11742. 1 hit.
Pfami PF01532. Glyco_hydro_47. 1 hit.
[Graphical view ]
PRINTSi PR00747. GLYHDRLASE47.
SUPFAMi SSF48225. SSF48225. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of the alpha1,2-mannosidase gene (Mns1) in Candida albicans."
    Mora-Montes H.M., Flores-Carreon A., Ponce-Noyola P., Lopez-Romero E., Zinker-Ruzal S.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26555.

Entry informationi

Entry nameiMNS1_CANAX
AccessioniPrimary (citable) accession number: Q8J0Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3