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Q8J0E6

- PYRF_TORDE

UniProt

Q8J0E6 - PYRF_TORDE

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
URA3
Organism
Torulaspora delbrueckii (Yeast) (Candida colliculosa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371Substrate By similarity
Active sitei93 – 931Proton donor By similarity
Binding sitei217 – 2171Substrate By similarity
Binding sitei235 – 2351Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiTorulaspora delbrueckii (Yeast) (Candida colliculosa)
Taxonomic identifieri4950 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Orotidine 5'-phosphate decarboxylasePRO_0000134686Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8J0E6.
SMRiQ8J0E6. Positions 1-263.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 613Substrate binding By similarity
Regioni91 – 10010Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8J0E6-1 [UniParc]FASTAAdd to Basket

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MSVATYQERA AKHPSPVASK LLNLMHEKKT NLCASLDVNT TEELLKLVDT    50
LGPYICLLKT HIDIISDFSI DGTVKPLKEL AKKHNFMIFE DRKFADIGNT 100
VKLQYSSGVY RIAEWADITN AHGVTGAGIV TGLKQAAQET TNEPRGLLML 150
AELSSKGSLA HGEYTQGTVE IAKTDKDFVI GFIAQRDMGG REEGYDWLIM 200
TPGVGLDDKG DALGQQYRTV DEVVSTGSDI IIVGRGLFAK GRDPRVEGER 250
YRKAGWEAYE KRCQ 264
Length:264
Mass (Da):29,099
Last modified:March 1, 2003 - v1
Checksum:i65655EB51BAF7E7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF518402 Genomic DNA. Translation: AAN71840.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF518402 Genomic DNA. Translation: AAN71840.1 .

3D structure databases

ProteinModelPortali Q8J0E6.
SMRi Q8J0E6. Positions 1-263.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the gene URA3 encoding the orotidine 5'-phosphate decarboxylase from Torulaspora delbrueckii."
    Hernandez-Lopez M.J., Prieto J.A., Randez-Gil F.
    Yeast 19:1431-1435(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IGC 5321.

Entry informationi

Entry nameiPYRF_TORDE
AccessioniPrimary (citable) accession number: Q8J0E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: October 16, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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