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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Torulaspora delbrueckii (Yeast) (Candida colliculosa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Orotidine 5'-phosphate decarboxylase (URA3)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37SubstrateBy similarity1
Active sitei93Proton donorPROSITE-ProRule annotation1
Binding sitei217SubstrateBy similarity1
Binding sitei235SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiTorulaspora delbrueckii (Yeast) (Candida colliculosa)
Taxonomic identifieri4950 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346861 – 264Orotidine 5'-phosphate decarboxylaseAdd BLAST264

Proteomic databases

PRIDEiQ8J0E6.

Interactioni

Protein-protein interaction databases

STRINGi4950.XP_003679867.1.

Structurei

3D structure databases

ProteinModelPortaliQ8J0E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 61Substrate bindingBy similarity3
Regioni91 – 100Substrate bindingBy similarity10

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8J0E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVATYQERA AKHPSPVASK LLNLMHEKKT NLCASLDVNT TEELLKLVDT
60 70 80 90 100
LGPYICLLKT HIDIISDFSI DGTVKPLKEL AKKHNFMIFE DRKFADIGNT
110 120 130 140 150
VKLQYSSGVY RIAEWADITN AHGVTGAGIV TGLKQAAQET TNEPRGLLML
160 170 180 190 200
AELSSKGSLA HGEYTQGTVE IAKTDKDFVI GFIAQRDMGG REEGYDWLIM
210 220 230 240 250
TPGVGLDDKG DALGQQYRTV DEVVSTGSDI IIVGRGLFAK GRDPRVEGER
260
YRKAGWEAYE KRCQ
Length:264
Mass (Da):29,099
Last modified:March 1, 2003 - v1
Checksum:i65655EB51BAF7E7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518402 Genomic DNA. Translation: AAN71840.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518402 Genomic DNA. Translation: AAN71840.1.

3D structure databases

ProteinModelPortaliQ8J0E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4950.XP_003679867.1.

Proteomic databases

PRIDEiQ8J0E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRF_TORDE
AccessioniPrimary (citable) accession number: Q8J0E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: October 5, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.