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Q8J0E6 (PYRF_TORDE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismTorulaspora delbrueckii (Yeast) (Candida colliculosa)
Taxonomic identifier4950 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeTorulaspora

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Orotidine 5'-phosphate decarboxylase
PRO_0000134686

Regions

Region59 – 613Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site371Substrate By similarity
Binding site2171Substrate By similarity
Binding site2351Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8J0E6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 65655EB51BAF7E7C

FASTA26429,099
        10         20         30         40         50         60 
MSVATYQERA AKHPSPVASK LLNLMHEKKT NLCASLDVNT TEELLKLVDT LGPYICLLKT 

        70         80         90        100        110        120 
HIDIISDFSI DGTVKPLKEL AKKHNFMIFE DRKFADIGNT VKLQYSSGVY RIAEWADITN 

       130        140        150        160        170        180 
AHGVTGAGIV TGLKQAAQET TNEPRGLLML AELSSKGSLA HGEYTQGTVE IAKTDKDFVI 

       190        200        210        220        230        240 
GFIAQRDMGG REEGYDWLIM TPGVGLDDKG DALGQQYRTV DEVVSTGSDI IIVGRGLFAK 

       250        260 
GRDPRVEGER YRKAGWEAYE KRCQ 

« Hide

References

[1]"Isolation and characterization of the gene URA3 encoding the orotidine 5'-phosphate decarboxylase from Torulaspora delbrueckii."
Hernandez-Lopez M.J., Prieto J.A., Randez-Gil F.
Yeast 19:1431-1435(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IGC 5321.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF518402 Genomic DNA. Translation: AAN71840.1.

3D structure databases

ProteinModelPortalQ8J0E6.
SMRQ8J0E6. Positions 1-263.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_TORDE
AccessionPrimary (citable) accession number: Q8J0E6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: October 16, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways