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Q8J093

- MPI_OGAPD

UniProt

Q8J093 - MPI_OGAPD

Protein

Mannose-6-phosphate isomerase

Gene

PMI40

Organism
Ogataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi112 – 1121ZincBy similarity
    Metal bindingi114 – 1141ZincBy similarity
    Metal bindingi139 – 1391ZincBy similarity
    Metal bindingi277 – 2771ZincBy similarity
    Active sitei296 – 2961By similarity

    GO - Molecular functioni

    1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00126; UER00423.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Name:PMI40
    ORF Names:HPODL_00814
    OrganismiOgataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
    Taxonomic identifieri871575 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea
    ProteomesiUP000008673: Chromosome III, UP000008673: Partially assembled WGS

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Mannose-6-phosphate isomerasePRO_0000194246Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8J093.
    SMRiQ8J093. Positions 3-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    OrthoDBiEOG7WDNCR.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR10309. PTHR10309. 1 hit.
    PfamiPF01238. PMI_typeI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSiPR00714. MAN6PISMRASE.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR00218. manA. 1 hit.
    PROSITEiPS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8J093-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAPKLFRV IGGAQNYDWG KLGSTSAVAR FAKLNDPENV SIEEEKPYAE    50
    LWMGTHPSVP TVSAQDRTPL RDLVRAAPEE MLGQDIIDKF GSKEGIPFLF 100
    KVLSIRKVLS IQAHPDKALA RQLHASDPKH YPDDNHKPEM AVAITDFEAF 150
    CGFKPLAEID ALLQKIPEFR ELVGDDVVAE FHSGIDSSDV AGKKKLLQKV 200
    FSRVMNSPES KFEPLAARLV ERTKSDPQLF GETLADLIQR LDAQFPNDIG 250
    LFCGCLLLNH CILKSGEAMF LEAKDPHAYI SGDIMECMAA SDNVIRAGFT 300
    PKFKDVEVLV DCLTYSFNPV EEQKLKPAPF PRGTGVAELK LYDPPIDEFS 350
    VLQTTFTSAG AEKFEGLDGP SLLIVTEGKG KIKLQGSDEA LDASTGNIFF 400
    VAPKAAIELV SESKDTFTSY RAFCEA 426
    Length:426
    Mass (Da):46,779
    Last modified:March 1, 2003 - v1
    Checksum:i8247706E7BECEE35
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454544 Genomic DNA. Translation: AAN52529.1.
    AF346819 Genomic DNA. Translation: AAN64443.1.
    AEOI02000005 Genomic DNA. Translation: ESX01420.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454544 Genomic DNA. Translation: AAN52529.1 .
    AF346819 Genomic DNA. Translation: AAN64443.1 .
    AEOI02000005 Genomic DNA. Translation: ESX01420.1 .

    3D structure databases

    ProteinModelPortali Q8J093.
    SMRi Q8J093. Positions 3-426.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7WDNCR.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00423 .

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR10309. PTHR10309. 1 hit.
    Pfami PF01238. PMI_typeI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSi PR00714. MAN6PISMRASE.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR00218. manA. 1 hit.
    PROSITEi PS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and functional analysis of the Hansenula polymorpha genomic fragment containing the YPT1 and PMI40 genes."
      Kim M.W., Agaphonov M.O., Kim J.Y., Rhee S.K., Kang H.A.
      Yeast 19:863-871(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 26012 / NRRL Y-7560 / DL-1.
    2. "Molecular cloning of the Hansenula polymorpha homolog of the Saccharomyces cerevisiae PMI40 gene."
      Kim M.W., Agaphonov M.O., Rhee S.K., Kang H.A.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 26012 / NRRL Y-7560 / DL-1.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 26012 / NRRL Y-7560 / DL-1.

    Entry informationi

    Entry nameiMPI_OGAPD
    AccessioniPrimary (citable) accession number: Q8J093
    Secondary accession number(s): E7R1T0, W1QIL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3