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Q8J093

- MPI_OGAPD

UniProt

Q8J093 - MPI_OGAPD

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Protein
Mannose-6-phosphate isomerase
Gene
PMI40, HPODL_00814
Organism
Ogataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi112 – 1121Zinc By similarity
Metal bindingi114 – 1141Zinc By similarity
Metal bindingi139 – 1391Zinc By similarity
Metal bindingi277 – 2771Zinc By similarity
Active sitei296 – 2961 By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:PMI40
ORF Names:HPODL_00814
OrganismiOgataea parapolymorpha (strain DL-1 / ATCC 26012 / NRRL Y-7560) (Yeast) (Hansenula polymorpha)
Taxonomic identifieri871575 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea
ProteomesiUP000008673: Chromosome III, UP000008673: Partially assembled WGS

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Mannose-6-phosphate isomerase
PRO_0000194246Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8J093.
SMRiQ8J093. Positions 3-426.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG7WDNCR.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8J093-1 [UniParc]FASTAAdd to Basket

« Hide

MSSAPKLFRV IGGAQNYDWG KLGSTSAVAR FAKLNDPENV SIEEEKPYAE    50
LWMGTHPSVP TVSAQDRTPL RDLVRAAPEE MLGQDIIDKF GSKEGIPFLF 100
KVLSIRKVLS IQAHPDKALA RQLHASDPKH YPDDNHKPEM AVAITDFEAF 150
CGFKPLAEID ALLQKIPEFR ELVGDDVVAE FHSGIDSSDV AGKKKLLQKV 200
FSRVMNSPES KFEPLAARLV ERTKSDPQLF GETLADLIQR LDAQFPNDIG 250
LFCGCLLLNH CILKSGEAMF LEAKDPHAYI SGDIMECMAA SDNVIRAGFT 300
PKFKDVEVLV DCLTYSFNPV EEQKLKPAPF PRGTGVAELK LYDPPIDEFS 350
VLQTTFTSAG AEKFEGLDGP SLLIVTEGKG KIKLQGSDEA LDASTGNIFF 400
VAPKAAIELV SESKDTFTSY RAFCEA 426
Length:426
Mass (Da):46,779
Last modified:March 1, 2003 - v1
Checksum:i8247706E7BECEE35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF454544 Genomic DNA. Translation: AAN52529.1.
AF346819 Genomic DNA. Translation: AAN64443.1.
AEOI02000005 Genomic DNA. Translation: ESX01420.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF454544 Genomic DNA. Translation: AAN52529.1 .
AF346819 Genomic DNA. Translation: AAN64443.1 .
AEOI02000005 Genomic DNA. Translation: ESX01420.1 .

3D structure databases

ProteinModelPortali Q8J093.
SMRi Q8J093. Positions 3-426.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7WDNCR.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing and functional analysis of the Hansenula polymorpha genomic fragment containing the YPT1 and PMI40 genes."
    Kim M.W., Agaphonov M.O., Kim J.Y., Rhee S.K., Kang H.A.
    Yeast 19:863-871(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26012 / NRRL Y-7560 / DL-1.
  2. "Molecular cloning of the Hansenula polymorpha homolog of the Saccharomyces cerevisiae PMI40 gene."
    Kim M.W., Agaphonov M.O., Rhee S.K., Kang H.A.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26012 / NRRL Y-7560 / DL-1.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 26012 / NRRL Y-7560 / DL-1.

Entry informationi

Entry nameiMPI_OGAPD
AccessioniPrimary (citable) accession number: Q8J093
Secondary accession number(s): E7R1T0, W1QIL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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