Reviewed,
UniProtKB/Swiss-Prot Q8J093 (MPI_PICAN)
Last modified
February 9, 2010.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mannose-6-phosphate isomerase EC=5.3.1.8 Alternative name(s): Phosphomannose isomerase Short name=PMI Phosphohexomutase | ||
| Gene names |
| ||
| Organism | Pichia angusta (Yeast) (Hansenula polymorpha) | ||
| Taxonomic identifier | 4905 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Pichia |
Protein attributes
| Sequence length | 426 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity. |
| Catalytic activity | D-mannose 6-phosphate = D-fructose 6-phosphate. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the mannose-6-phosphate isomerase type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Metal-binding Zinc |
| Molecular function | Isomerase |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 426 | 426 | Mannose-6-phosphate isomerase | PRO_0000194246 | |||||
Sites | |||||||||
| Active site | 296 | 1 | By similarity | ||||||
| Metal binding | 112 | 1 | Zinc By similarity | ||||||
| Metal binding | 114 | 1 | Zinc By similarity | ||||||
| Metal binding | 139 | 1 | Zinc By similarity | ||||||
| Metal binding | 277 | 1 | Zinc By similarity | ||||||
Sequences
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References
| [1] | "Sequencing and functional analysis of the Hansenula polymorpha genomic fragment containing the YPT1 and PMI40 genes." Kim M.W., Agaphonov M.O., Kim J.Y., Rhee S.K., Kang H.A. Yeast 19:863-871(2002) [PubMed: 12112240] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 26012 / DL-1 / NRRL Y-7560. |
| [2] | "Molecular cloning of the Hansenula polymorpha homolog of the Saccharomyces cerevisiae PMI40 gene." Kim M.W., Agaphonov M.O., Rhee S.K., Kang H.A. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 26012 / DL-1 / NRRL Y-7560. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF454544 Genomic DNA. Translation: AAN52529.1. AF346819 Genomic DNA. Translation: AAN64443.1. |
3D structure databases | |
| SMR | Q8J093. Positions 3-426. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 5.3.1.8. 276392. |
Family and domain databases | |
| InterPro | IPR011051. Cupin_RmlC_type. IPR001250. Man6P_Isoase-1. IPR016305. Mannose-6-P_Isomerase. IPR018050. Pmannose_isomerase-type1_CS. IPR014710. RmlC-like_jellyroll. [Graphical view] |
| Gene3D | G3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits. |
| Pfam | PF01238. PMI_typeI. 1 hit. [Graphical view] |
| PIRSF | PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit. |
| PRINTS | PR00714. MAN6PISMRASE. |
| TIGRFAMs | TIGR00218. manA. 1 hit. |
| PROSITE | PS00965. PMI_I_1. 1 hit. PS00966. PMI_I_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MPI_PICAN | ||||||||
| Accession | Primary (citable) accession number: Q8J093 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


