Reviewed, UniProtKB/Swiss-Prot Q8J025 (APCD1_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein APCDD1
Alternative name(s):
    Adenomatosis polyposis coli down-regulated 1 protein

Gene names

Name:	APCDD1
Synonyms:	DRAPC1
ORF Names:	FP7019

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probably plays a role in colorectal tumorigenesis. May be a developmental target gene of the Wnt/Beta-catenin pathway. Ref.1 UniProtKB Q3U128
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Ref.1
Induction	Transcriptionally regulated by the CTNNB1/TF7L2 complex. Ref.1
Sequence caution	The sequence AAQ04816.1 differs from that shown. Reason: Frameshift at position 133.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 514	488	Protein APCDD1		PRO_0000227520
Regions
	Topological domain	27 – 492	466	Extracellular Potential
	Transmembrane	493 – 512	20	Potential
	Topological domain	513 – 514	2	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	168	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	150	1	V → I: dbSNP rs3748415.		VAR_050667

Sequences

	Sequence		Length	Mass (Da)
	Q8J025-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 75DA7B8B38E3FFE5	FASTA	514	58,797
	10 20 30 40 50 60 MSWPRRLLLR YLFPALLLHG LGEGSALLHP DSRSHPRSLE KSAWRAFKES QCHHMLKHLH 70 80 90 100 110 120 NGARITVQMP PTIEGHWVST GCEVRSGPEF ITRSYRFYHN NTFKAYQFYY GSNRCTNPTY 130 140 150 160 170 180 TLIIRGKIRL RQASWIIRGG TEADYQLHNV QVICHTEAVA EKLGQQVNRT CPGFLADGGP 190 200 210 220 230 240 WVQDVAYDLW REENGCECTK AVNFAMHELQ LIRVEKQYLH HNLDHLVEEL FLGDIHTDAT 250 260 270 280 290 300 QRMFYRPSSY QPPLQNAKNH DHACIACRII YRSDEHHPPI LPPKADLTIG LHGEWVSQRC 310 320 330 340 350 360 EVRPEVLFLT RHFIFHDNNN TWEGHYYHYS DPVCKHPTFS IYARGRYSRG VLSSRVMGGT 370 380 390 400 410 420 EFVFKVNHMK VTPMDAATAS LLNVFNGNEC GAEGSWQVGI QQDVTHTNGC VALGIKLPHT 430 440 450 460 470 480 EYEIFKMEQD ARGRYLLFNG QRPSDGSSPD RPEKRATSYQ MPLVQCASSS PRAEDLAEDS 490 500 510 GSSLYGRAPG RHTWSLLLAA LACLVPLLHW NIRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel human gene, APCDD1, as a direct target of the b-catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis." Takahashi M., Fujita M., Furukawa Y., Hamamoto R., Shimokawa T., Miwa N., Ogawa M., Nakamura Y. Cancer Res. 62:5651-5656(2002) [PubMed: 12384519] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION. Tissue: Colon.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[3]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-514.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB056722 mRNA. Translation: BAC15563.1. AB104887 mRNA. Translation: BAC65165.1. BC053324 mRNA. Translation: AAH53324.1. AF461902 mRNA. Translation: AAQ04816.1. Frameshift.
IPI	IPI00216332.
RefSeq	NP_694545.1.
UniGene	Hs.293274
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8J025.
Genome annotation databases
Ensembl	ENSG00000154856. Homo sapiens. [Contig view]
GeneID	147495.
KEGG	hsa:147495.
Organism-specific databases
GeneCards	GC18P010444.
H-InvDB	HIX0014332.
HGNC	HGNC:15718. APCDD1.
HPA	HPA014468.
MIM	607479. gene.
PharmGKB	PA24876.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8J025.
HOVERGEN	Q8J025.
OMA	Q8J025. GRYSRGV.
Gene expression databases
ArrayExpress	Q8J025.
Bgee	Q8J025.
CleanEx	HS_APCDD1.
GermOnline	ENSG00000154856. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	85626.
SOURCE	Search...

Entry information

Entry name

APCD1_HUMAN

Accession

Primary (citable) accession number: Q8J025
Secondary accession number(s): Q71M25

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)