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Reviewed, UniProtKB/Swiss-Prot Q8J025 (APCD1_HUMAN)

Last modified June 16, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein APCDD1
Alternative name(s):
    Adenomatosis polyposis coli down-regulated 1 protein
Gene names
Name: APCDD1
Synonyms: DRAPC1
ORF Names: FP7019
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Probably plays a role in colorectal tumorigenesis. May be a developmental target gene of the Wnt/Beta-catenin pathway. Ref.1 UniProtKB Q3U128

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Ref.1

Induction

Transcriptionally regulated by the CTNNB1/TF7L2 complex. Ref.1

Sequence caution

The sequence AAQ04816.1 differs from that shown. Reason: Frameshift at position 133.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
   PTMGlycoprotein
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 514488Protein APCDD1
PRO_0000227520

Regions

Topological domain27 – 492466Extracellular Potential
Transmembrane493 – 51220 Potential
Topological domain513 – 5142Cytoplasmic Potential

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...) Potential

Natural variations

Natural variant1501V → I: dbSNP rs3748415.
VAR_050667

Sequences

Sequence LengthMass (Da)Tools
Q8J025-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 75DA7B8B38E3FFE5

FASTA51458,797
        10         20         30         40         50         60 
MSWPRRLLLR YLFPALLLHG LGEGSALLHP DSRSHPRSLE KSAWRAFKES QCHHMLKHLH 

        70         80         90        100        110        120 
NGARITVQMP PTIEGHWVST GCEVRSGPEF ITRSYRFYHN NTFKAYQFYY GSNRCTNPTY 

       130        140        150        160        170        180 
TLIIRGKIRL RQASWIIRGG TEADYQLHNV QVICHTEAVA EKLGQQVNRT CPGFLADGGP 

       190        200        210        220        230        240 
WVQDVAYDLW REENGCECTK AVNFAMHELQ LIRVEKQYLH HNLDHLVEEL FLGDIHTDAT 

       250        260        270        280        290        300 
QRMFYRPSSY QPPLQNAKNH DHACIACRII YRSDEHHPPI LPPKADLTIG LHGEWVSQRC 

       310        320        330        340        350        360 
EVRPEVLFLT RHFIFHDNNN TWEGHYYHYS DPVCKHPTFS IYARGRYSRG VLSSRVMGGT 

       370        380        390        400        410        420 
EFVFKVNHMK VTPMDAATAS LLNVFNGNEC GAEGSWQVGI QQDVTHTNGC VALGIKLPHT 

       430        440        450        460        470        480 
EYEIFKMEQD ARGRYLLFNG QRPSDGSSPD RPEKRATSYQ MPLVQCASSS PRAEDLAEDS 

       490        500        510 
GSSLYGRAPG RHTWSLLLAA LACLVPLLHW NIRR 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a novel human gene, APCDD1, as a direct target of the b-catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis."
Takahashi M., Fujita M., Furukawa Y., Hamamoto R., Shimokawa T., Miwa N., Ogawa M., Nakamura Y.
Cancer Res. 62:5651-5656(2002) [PubMed: 12384519] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
Tissue: Colon.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[3]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-514.

Cross-references

Sequence databases

AB056722 mRNA. Translation: BAC15563.1.
AB104887 mRNA. Translation: BAC65165.1.
BC053324 mRNA. Translation: AAH53324.1.
AF461902 mRNA. Translation: AAQ04816.1. Frameshift.
IPIIPI00216332.
RefSeqNP_694545.1.
UniGeneHs.293274

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ8J025.

Genome annotation databases

EnsemblENSG00000154856. Homo sapiens. [Contig view]
GeneID147495.
KEGGhsa:147495.

Organism-specific databases

GeneCardsGC18P010444.
H-InvDBHIX0014332.
HGNCHGNC:15718. APCDD1.
HPAHPA014468.
MIM607479. gene.
PharmGKBPA24876.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ8J025.
HOVERGENQ8J025.
OMAQ8J025. GRYSRGV.

Gene expression databases

ArrayExpressQ8J025.
BgeeQ8J025.
CleanExHS_APCDD1.
GermOnlineENSG00000154856. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio85626.
SOURCESearch...

Entry information

Entry nameAPCD1_HUMAN
AccessionPrimary (citable) accession number: Q8J025
Secondary accession number(s): Q71M25
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents