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Q8IZZ2

- Q8IZZ2_HUMAN

UniProt

Q8IZZ2 - Q8IZZ2_HUMAN

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Protein
Submitted name:

Leukemogenic homolog protein

Gene

WUGSC:H_NH0444B04.1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. definitive hemopoiesis Source: Ensembl
  3. lens morphogenesis in camera-type eye Source: Ensembl
  4. megakaryocyte development Source: Ensembl
  5. negative regulation of myeloid cell differentiation Source: Ensembl
  6. negative regulation of neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Leukemogenic homolog proteinImported
Gene namesi
Name:WUGSC:H_NH0444B04.1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiQ8IZZ2.
ExpressionAtlasiQ8IZZ2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ8IZZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8IZZ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAVSQGT
60 70 80 90
PYNPDGQPMG GFVMDGQQHM GIRAPGPMSG MGMNMGMEGQ WHYM
Length:94
Mass (Da):10,576
Last modified:March 1, 2003 - v1
Checksum:i61B74FD677441274
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007392 Genomic DNA. Translation: AAN40012.1.
UniGeneiHs.526754.
Hs.603755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007392 Genomic DNA. Translation: AAN40012.1 .
UniGenei Hs.526754.
Hs.603755.

3D structure databases

ProteinModelPortali Q8IZZ2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

ChiTaRSi MEIS1. human.

Gene expression databases

Bgeei Q8IZZ2.
ExpressionAtlasi Q8IZZ2. baseline and differential.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF05920. Homeobox_KN. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Toward a complete human genome sequence."
    Wilson R.
    Genome Res. 8:1097-1108(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The sequence of Homo sapiens BAC clone RP11-444B4."
    Kozlowicz A., Maupin R., Rice L.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Waterston R.H.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Waterston R.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8IZZ2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZZ2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.