Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BH3-like motif-containing cell death inducer

Gene

BLID

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
BH3-like motif-containing cell death inducer
Alternative name(s):
Breast cancer cell protein 2
Gene namesi
Name:BLID
Synonyms:BRCC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33495. BLID.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi5 – 51L → E: Fails to induce apoptosis. 1 Publication

Organism-specific databases

PharmGKBiPA162377555.

Polymorphism and mutation databases

BioMutaiBLID.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108BH3-like motif-containing cell death inducerPRO_0000301669Add
BLAST

Proteomic databases

PaxDbiQ8IZY5.
PRIDEiQ8IZY5.

PTM databases

iPTMnetiQ8IZY5.
PhosphoSiteiQ8IZY5.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ8IZY5.
CleanExiHS_BLID.
GenevisibleiQ8IZY5. HS.

Interactioni

Protein-protein interaction databases

BioGridi136097. 11 interactions.
IntActiQ8IZY5. 9 interactions.
STRINGi9606.ENSP00000453153.

Structurei

3D structure databases

ProteinModelPortaliQ8IZY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi5 – 128BH3-like

Phylogenomic databases

eggNOGiENOG410JMQ9. Eukaryota.
ENOG4111C8H. LUCA.
GeneTreeiENSGT00520000061087.
HOGENOMiHOG000095235.
InParanoidiQ8IZY5.
OMAiIYPEAKA.
OrthoDBiEOG74R1SZ.

Sequencei

Sequence statusi: Complete.

Q8IZY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTLLPIEGQ EIHFFEILES ECVLYTGWIE RASGSSIYPE AKARLPLEAL
60 70 80 90 100
LGSNKEPMLP KETVLSLKRY NLGSSAMKRN VPGHVLQRPS YLTRIQVTLL

CNSSAEAL
Length:108
Mass (Da):12,045
Last modified:September 11, 2007 - v2
Checksum:iA08A98D31676DF8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121I → V in AAN31127 (PubMed:15069058).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761A → D.
Corresponds to variant rs7116084 [ dbSNP | Ensembl ].
VAR_056750

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303179 mRNA. Translation: AAN31127.1.
BC130361 mRNA. Translation: AAI30362.1.
BC130363 mRNA. Translation: AAI30364.1.
CCDSiCCDS31693.1.
RefSeqiNP_001001786.2. NM_001001786.2.
UniGeneiHs.686109.

Genome annotation databases

EnsembliENST00000560104; ENSP00000453153; ENSG00000259571.
GeneIDi414899.
KEGGihsa:414899.
UCSCiuc001pyf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303179 mRNA. Translation: AAN31127.1.
BC130361 mRNA. Translation: AAI30362.1.
BC130363 mRNA. Translation: AAI30364.1.
CCDSiCCDS31693.1.
RefSeqiNP_001001786.2. NM_001001786.2.
UniGeneiHs.686109.

3D structure databases

ProteinModelPortaliQ8IZY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136097. 11 interactions.
IntActiQ8IZY5. 9 interactions.
STRINGi9606.ENSP00000453153.

PTM databases

iPTMnetiQ8IZY5.
PhosphoSiteiQ8IZY5.

Polymorphism and mutation databases

BioMutaiBLID.

Proteomic databases

PaxDbiQ8IZY5.
PRIDEiQ8IZY5.

Protocols and materials databases

DNASUi414899.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000560104; ENSP00000453153; ENSG00000259571.
GeneIDi414899.
KEGGihsa:414899.
UCSCiuc001pyf.3. human.

Organism-specific databases

CTDi414899.
GeneCardsiBLID.
HGNCiHGNC:33495. BLID.
MIMi608853. gene.
neXtProtiNX_Q8IZY5.
PharmGKBiPA162377555.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JMQ9. Eukaryota.
ENOG4111C8H. LUCA.
GeneTreeiENSGT00520000061087.
HOGENOMiHOG000095235.
InParanoidiQ8IZY5.
OMAiIYPEAKA.
OrthoDBiEOG74R1SZ.

Miscellaneous databases

GenomeRNAii414899.
PROiQ8IZY5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZY5.
CleanExiHS_BLID.
GenevisibleiQ8IZY5. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner."
    Broustas C.G., Gokhale P.C., Rahman A., Dritschilo A., Ahmad I., Kasid U.
    J. Biol. Chem. 279:26780-26788(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LEU-5.
    Tissue: Mammary cancer.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiBLID_HUMAN
AccessioniPrimary (citable) accession number: Q8IZY5
Secondary accession number(s): A1L416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 8, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.