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Protein

ATP-binding cassette sub-family A member 7

Gene

ABCA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi841 – 848ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1827 – 1834ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • apolipoprotein A-I receptor activity Source: Alzheimers_University_of_Toronto
  • ATPase activity Source: BHF-UCL
  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: ProtInc
  • phosphatidylcholine-translocating ATPase activity Source: BHF-UCL
  • phosphatidylserine-translocating ATPase activity Source: BHF-UCL
  • transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phagocytosis, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1369062. ABC transporters in lipid homeostasis.

Protein family/group databases

TCDBi3.A.1.211.10. the atp-binding cassette (abc) superfamily.

Chemistry databases

SwissLipidsiSLP:000000346.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 7
Alternative name(s):
ABCA-SSN
Autoantigen SS-N
Macrophage ABC transporter
Gene namesi
Name:ABCA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:37. ABCA7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 549ExtracellularBy similarityAdd BLAST507
Transmembranei550 – 570HelicalSequence analysisAdd BLAST21
Transmembranei593 – 613HelicalSequence analysisAdd BLAST21
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21
Transmembranei655 – 675HelicalSequence analysisAdd BLAST21
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Transmembranei727 – 747HelicalSequence analysisAdd BLAST21
Transmembranei849 – 869HelicalSequence analysisAdd BLAST21
Transmembranei1243 – 1263HelicalSequence analysisAdd BLAST21
Topological domaini1264 – 1537ExtracellularBy similarityAdd BLAST274
Transmembranei1538 – 1558HelicalSequence analysisAdd BLAST21
Transmembranei1584 – 1604HelicalSequence analysisAdd BLAST21
Transmembranei1621 – 1641HelicalSequence analysisAdd BLAST21
Transmembranei1649 – 1669HelicalSequence analysisAdd BLAST21
Transmembranei1683 – 1703HelicalSequence analysisAdd BLAST21
Transmembranei1729 – 1749HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • ATP-binding cassette (ABC) transporter complex Source: ProtInc
  • cell junction Source: HPA
  • cell surface Source: Alzheimers_University_of_Toronto
  • early endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: HPA
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: ProtInc
  • intracellular membrane-bounded organelle Source: GO_Central
  • phagocytic cup Source: Alzheimers_University_of_Toronto
  • plasma membrane Source: Alzheimers_University_of_Toronto
  • ruffle membrane Source: Alzheimers_University_of_Toronto
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Alzheimer disease 9 (AD9)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA familial, late-onset form of Alzheimer disease, a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
See also OMIM:608907

Keywords - Diseasei

Alzheimer disease, Amyloidosis, Neurodegeneration

Organism-specific databases

DisGeNETi10347.
MIMi608907. phenotype.
OpenTargetsiENSG00000064687.
PharmGKBiPA24382.

Polymorphism and mutation databases

BioMutaiABCA7.
DMDMi161784300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002506741 – 2146ATP-binding cassette sub-family A member 7Add BLAST2146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 225By similarity
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1345 ↔ 1359By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8IZY2.
PaxDbiQ8IZY2.
PeptideAtlasiQ8IZY2.
PRIDEiQ8IZY2.

PTM databases

iPTMnetiQ8IZY2.
PhosphoSitePlusiQ8IZY2.

Expressioni

Tissue specificityi

Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow.3 Publications

Developmental stagei

Expressed in fetal tissues. Strongly expressed in fetal liver.2 Publications

Inductioni

Up-regulated in macrophages upon cholesterol uptake and inversely regulated upon cholesterol deloading from the cells (at protein level). Up-regulated in keratinocytes during terminal differentiation.2 Publications

Gene expression databases

BgeeiENSG00000064687.
CleanExiHS_ABCA7.
ExpressionAtlasiQ8IZY2. baseline and differential.
GenevisibleiQ8IZY2. HS.

Organism-specific databases

HPAiHPA041564.

Interactioni

Protein-protein interaction databases

BioGridi115629. 8 interactors.
IntActiQ8IZY2. 7 interactors.
STRINGi9606.ENSP00000263094.

Structurei

3D structure databases

ProteinModelPortaliQ8IZY2.
SMRiQ8IZY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini807 – 1038ABC transporter 1PROSITE-ProRule annotationAdd BLAST232
Domaini1793 – 2025ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiQ8IZY2.
KOiK05645.
OMAiAEHGVED.
OrthoDBiEOG091G007E.
PhylomeDBiQ8IZY2.
TreeFamiTF105191.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030369. ABCA7.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 6 hits.
PTHR19229:SF49. PTHR19229:SF49. 6 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZY2-1) [UniParc]FASTAAdd to basket
Also known as: Type 1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFWTQLMLL LWKNFMYRRR QPVQLLVELL WPLFLFFILV AVRHSHPPLE
60 70 80 90 100
HHECHFPNKP LPSAGTVPWL QGLICNVNNT CFPQLTPGEE PGRLSNFNDS
110 120 130 140 150
LVSRLLADAR TVLGGASAHR TLAGLGKLIA TLRAARSTAQ PQPTKQSPLE
160 170 180 190 200
PPMLDVAELL TSLLRTESLG LALGQAQEPL HSLLEAAEDL AQELLALRSL
210 220 230 240 250
VELRALLQRP RGTSGPLELL SEALCSVRGP SSTVGPSLNW YEASDLMELV
260 270 280 290 300
GQEPESALPD SSLSPACSEL IGALDSHPLS RLLWRRLKPL ILGKLLFAPD
310 320 330 340 350
TPFTRKLMAQ VNRTFEELTL LRDVREVWEM LGPRIFTFMN DSSNVAMLQR
360 370 380 390 400
LLQMQDEGRR QPRPGGRDHM EALRSFLDPG SGGYSWQDAH ADVGHLVGTL
410 420 430 440 450
GRVTECLSLD KLEAAPSEAA LVSRALQLLA EHRFWAGVVF LGPEDSSDPT
460 470 480 490 500
EHPTPDLGPG HVRIKIRMDI DVVTRTNKIR DRFWDPGPAA DPLTDLRYVW
510 520 530 540 550
GGFVYLQDLV ERAAVRVLSG ANPRAGLYLQ QMPYPCYVDD VFLRVLSRSL
560 570 580 590 600
PLFLTLAWIY SVTLTVKAVV REKETRLRDT MRAMGLSRAV LWLGWFLSCL
610 620 630 640 650
GPFLLSAALL VLVLKLGDIL PYSHPGVVFL FLAAFAVATV TQSFLLSAFF
660 670 680 690 700
SRANLAAACG GLAYFSLYLP YVLCVAWRDR LPAGGRVAAS LLSPVAFGFG
710 720 730 740 750
CESLALLEEQ GEGAQWHNVG TRPTADVFSL AQVSGLLLLD AALYGLATWY
760 770 780 790 800
LEAVCPGQYG IPEPWNFPFR RSYWCGPRPP KSPAPCPTPL DPKVLVEEAP
810 820 830 840 850
PGLSPGVSVR SLEKRFPGSP QPALRGLSLD FYQGHITAFL GHNGAGKTTT
860 870 880 890 900
LSILSGLFPP SGGSAFILGH DVRSSMAAIR PHLGVCPQYN VLFDMLTVDE
910 920 930 940 950
HVWFYGRLKG LSAAVVGPEQ DRLLQDVGLV SKQSVQTRHL SGGMQRKLSV
960 970 980 990 1000
AIAFVGGSQV VILDEPTAGV DPASRRGIWE LLLKYREGRT LILSTHHLDE
1010 1020 1030 1040 1050
AELLGDRVAV VAGGRLCCCG SPLFLRRHLG SGYYLTLVKA RLPLTTNEKA
1060 1070 1080 1090 1100
DTDMEGSVDT RQEKKNGSQG SRVGTPQLLA LVQHWVPGAR LVEELPHELV
1110 1120 1130 1140 1150
LVLPYTGAHD GSFATLFREL DTRLAELRLT GYGISDTSLE EIFLKVVEEC
1160 1170 1180 1190 1200
AADTDMEDGS CGQHLCTGIA GLDVTLRLKM PPQETALENG EPAGSAPETD
1210 1220 1230 1240 1250
QGSGPDAVGR VQGWALTRQQ LQALLLKRFL LARRSRRGLF AQIVLPALFV
1260 1270 1280 1290 1300
GLALVFSLIV PPFGHYPALR LSPTMYGAQV SFFSEDAPGD PGRARLLEAL
1310 1320 1330 1340 1350
LQEAGLEEPP VQHSSHRFSA PEVPAEVAKV LASGNWTPES PSPACQCSRP
1360 1370 1380 1390 1400
GARRLLPDCP AAAGGPPPPQ AVTGSGEVVQ NLTGRNLSDF LVKTYPRLVR
1410 1420 1430 1440 1450
QGLKTKKWVN EVRYGGFSLG GRDPGLPSGQ ELGRSVEELW ALLSPLPGGA
1460 1470 1480 1490 1500
LDRVLKNLTA WAHSLDAQDS LKIWFNNKGW HSMVAFVNRA SNAILRAHLP
1510 1520 1530 1540 1550
PGPARHAHSI TTLNHPLNLT KEQLSEGALM ASSVDVLVSI CVVFAMSFVP
1560 1570 1580 1590 1600
ASFTLVLIEE RVTRAKHLQL MGGLSPTLYW LGNFLWDMCN YLVPACIVVL
1610 1620 1630 1640 1650
IFLAFQQRAY VAPANLPALL LLLLLYGWSI TPLMYPASFF FSVPSTAYVV
1660 1670 1680 1690 1700
LTCINLFIGI NGSMATFVLE LFSDQKLQEV SRILKQVFLI FPHFCLGRGL
1710 1720 1730 1740 1750
IDMVRNQAMA DAFERLGDRQ FQSPLRWEVV GKNLLAMVIQ GPLFLLFTLL
1760 1770 1780 1790 1800
LQHRSQLLPQ PRVRSLPLLG EEDEDVARER ERVVQGATQG DVLVLRNLTK
1810 1820 1830 1840 1850
VYRGQRMPAV DRLCLGIPPG ECFGLLGVNG AGKTSTFRMV TGDTLASRGE
1860 1870 1880 1890 1900
AVLAGHSVAR EPSAAHLSMG YCPQSDAIFE LLTGREHLEL LARLRGVPEA
1910 1920 1930 1940 1950
QVAQTAGSGL ARLGLSWYAD RPAGTYSGGN KRKLATALAL VGDPAVVFLD
1960 1970 1980 1990 2000
EPTTGMDPSA RRFLWNSLLA VVREGRSVML TSHSMEECEA LCSRLAIMVN
2010 2020 2030 2040 2050
GRFRCLGSPQ HLKGRFAAGH TLTLRVPAAR SQPAAAFVAA EFPGAELREA
2060 2070 2080 2090 2100
HGGRLRFQLP PGGRCALARV FGELAVHGAE HGVEDFSVSQ TMLEEVFLYF
2110 2120 2130 2140
SKDQGKDEDT EEQKEAGVGV DPAPGLQHPK RVSQFLDDPS TAETVL
Length:2,146
Mass (Da):234,350
Last modified:December 4, 2007 - v3
Checksum:i6EA624088E74FEE6
GO
Isoform 2 (identifier: Q8IZY2-2) [UniParc]FASTAAdd to basket
Also known as: Type 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     139-166: AQPQPTKQSPLEPPMLDVAELLTSLLRT → MVCLGTGQSAGPLVSVQNHCPPCGLSPQ

Note: Inactive for apoA-I-mediated lipid release.
Show »
Length:2,008
Mass (Da):218,497
Checksum:i2B52CABF87220A7B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1503P → R in AAF85794 (PubMed:10873640).Curated1
Sequence conflicti1503P → R in BAB62294 (PubMed:11355874).Curated1
Sequence conflicti1525S → F in AAF85794 (PubMed:10873640).Curated1
Sequence conflicti1525S → F in AAN04657 (PubMed:11095984).Curated1
Sequence conflicti1525S → F in BAB62294 (PubMed:11355874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027581188E → G.2 PublicationsCorresponds to variant rs3764645dbSNPEnsembl.1
Natural variantiVAR_027582319T → A.1 PublicationCorresponds to variant rs3752232dbSNPEnsembl.1
Natural variantiVAR_027583395H → R.1 PublicationCorresponds to variant rs3764647dbSNPEnsembl.1
Natural variantiVAR_027584463R → H.1 PublicationCorresponds to variant rs3752233dbSNPEnsembl.1
Natural variantiVAR_060985676A → T.Corresponds to variant rs59851484dbSNPEnsembl.1
Natural variantiVAR_027585718N → T.1 PublicationCorresponds to variant rs3752239dbSNPEnsembl.1
Natural variantiVAR_0275861349R → Q.3 PublicationsCorresponds to variant rs3745842dbSNPEnsembl.1
Natural variantiVAR_0275871527G → A.4 PublicationsCorresponds to variant rs3752246dbSNPEnsembl.1
Natural variantiVAR_0275881686Q → R.1 PublicationCorresponds to variant rs4147918dbSNPEnsembl.1
Natural variantiVAR_0275892045A → S.4 PublicationsCorresponds to variant rs4147934dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0207011 – 138Missing in isoform 2. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_020702139 – 166AQPQP…SLLRT → MVCLGTGQSAGPLVSVQNHC PPCGLSPQ in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250238 mRNA. Translation: AAF85794.1.
AF311102
, AF311058, AF311059, AF311060, AF311061, AF311062, AF311063, AF311064, AF311065, AF311066, AF311067, AF311068, AF311057, AF311069, AF311070, AF311071, AF311072, AF311073, AF311074, AF311075, AF311076, AF311077, AF311078, AF311079, AF311080, AF311081, AF311082, AF311083, AF311084, AF311085, AF311086, AF311087, AF311088, AF311089, AF311090, AF311091, AF311092, AF311093, AF311094, AF311095, AF311096, AF311097, AF311098, AF311099, AF311100, AF311101 Genomic DNA. Translation: AAN04657.1.
AB055390 mRNA. Translation: BAB62294.1.
AF328787 mRNA. Translation: AAK00959.1.
AC011558 Genomic DNA. No translation available.
AF140342 mRNA. Translation: AAF06727.1.
CCDSiCCDS12055.1. [Q8IZY2-1]
RefSeqiNP_061985.2. NM_019112.3. [Q8IZY2-1]
XP_011525930.1. XM_011527628.2. [Q8IZY2-1]
UniGeneiHs.134514.

Genome annotation databases

EnsembliENST00000263094; ENSP00000263094; ENSG00000064687. [Q8IZY2-1]
ENST00000433129; ENSP00000414062; ENSG00000064687. [Q8IZY2-1]
ENST00000435683; ENSP00000465322; ENSG00000064687. [Q8IZY2-2]
GeneIDi10347.
KEGGihsa:10347.
UCSCiuc002lqw.5. human. [Q8IZY2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250238 mRNA. Translation: AAF85794.1.
AF311102
, AF311058, AF311059, AF311060, AF311061, AF311062, AF311063, AF311064, AF311065, AF311066, AF311067, AF311068, AF311057, AF311069, AF311070, AF311071, AF311072, AF311073, AF311074, AF311075, AF311076, AF311077, AF311078, AF311079, AF311080, AF311081, AF311082, AF311083, AF311084, AF311085, AF311086, AF311087, AF311088, AF311089, AF311090, AF311091, AF311092, AF311093, AF311094, AF311095, AF311096, AF311097, AF311098, AF311099, AF311100, AF311101 Genomic DNA. Translation: AAN04657.1.
AB055390 mRNA. Translation: BAB62294.1.
AF328787 mRNA. Translation: AAK00959.1.
AC011558 Genomic DNA. No translation available.
AF140342 mRNA. Translation: AAF06727.1.
CCDSiCCDS12055.1. [Q8IZY2-1]
RefSeqiNP_061985.2. NM_019112.3. [Q8IZY2-1]
XP_011525930.1. XM_011527628.2. [Q8IZY2-1]
UniGeneiHs.134514.

3D structure databases

ProteinModelPortaliQ8IZY2.
SMRiQ8IZY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115629. 8 interactors.
IntActiQ8IZY2. 7 interactors.
STRINGi9606.ENSP00000263094.

Chemistry databases

SwissLipidsiSLP:000000346.

Protein family/group databases

TCDBi3.A.1.211.10. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ8IZY2.
PhosphoSitePlusiQ8IZY2.

Polymorphism and mutation databases

BioMutaiABCA7.
DMDMi161784300.

Proteomic databases

MaxQBiQ8IZY2.
PaxDbiQ8IZY2.
PeptideAtlasiQ8IZY2.
PRIDEiQ8IZY2.

Protocols and materials databases

DNASUi10347.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263094; ENSP00000263094; ENSG00000064687. [Q8IZY2-1]
ENST00000433129; ENSP00000414062; ENSG00000064687. [Q8IZY2-1]
ENST00000435683; ENSP00000465322; ENSG00000064687. [Q8IZY2-2]
GeneIDi10347.
KEGGihsa:10347.
UCSCiuc002lqw.5. human. [Q8IZY2-1]

Organism-specific databases

CTDi10347.
DisGeNETi10347.
GeneCardsiABCA7.
H-InvDBHIX0014569.
HGNCiHGNC:37. ABCA7.
HPAiHPA041564.
MIMi605414. gene.
608907. phenotype.
neXtProtiNX_Q8IZY2.
OpenTargetsiENSG00000064687.
PharmGKBiPA24382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00760000118965.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiQ8IZY2.
KOiK05645.
OMAiAEHGVED.
OrthoDBiEOG091G007E.
PhylomeDBiQ8IZY2.
TreeFamiTF105191.

Enzyme and pathway databases

ReactomeiR-HSA-1369062. ABC transporters in lipid homeostasis.

Miscellaneous databases

ChiTaRSiABCA7. human.
GeneWikiiABCA7.
GenomeRNAii10347.
PROiQ8IZY2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064687.
CleanExiHS_ABCA7.
ExpressionAtlasiQ8IZY2. baseline and differential.
GenevisibleiQ8IZY2. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030369. ABCA7.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 6 hits.
PTHR19229:SF49. PTHR19229:SF49. 6 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCA7_HUMAN
AccessioniPrimary (citable) accession number: Q8IZY2
Secondary accession number(s): Q96S58
, Q9BZC4, Q9NR73, Q9UKP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.