ID   TAF1L_HUMAN             Reviewed;        1826 AA.
AC   Q8IZX4; Q0VG57;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 166.
DE   RecName: Full=Transcription initiation factor TFIID subunit 1-like;
DE   AltName: Full=TAF(II)210;
DE   AltName: Full=TBP-associated factor 1-like;
DE   AltName: Full=TBP-associated factor 210 kDa;
DE   AltName: Full=Transcription initiation factor TFIID 210 kDa subunit;
GN   Name=TAF1L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH TBP.
RC   TISSUE=Testis;
RX   PubMed=12217962; DOI=10.1093/hmg/11.19.2341;
RA   Wang P.J., Page D.C.;
RT   "Functional substitution for TAF(II)250 by a retroposed homolog that is
RT   expressed in human spermatogenesis.";
RL   Hum. Mol. Genet. 11:2341-2346(2002).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1523-1654, AND SUBUNIT.
RX   PubMed=22464331; DOI=10.1016/j.cell.2012.02.013;
RA   Filippakopoulos P., Picaud S., Mangos M., Keates T., Lambert J.P.,
RA   Barsyte-Lovejoy D., Felletar I., Volkmer R., Muller S., Pawson T.,
RA   Gingras A.C., Arrowsmith C.H., Knapp S.;
RT   "Histone recognition and large-scale structural analysis of the human
RT   bromodomain family.";
RL   Cell 149:214-231(2012).
RN   [3]
RP   VARIANTS [LARGE SCALE ANALYSIS] ALA-47; GLU-171; ALA-256; VAL-371; ASN-532;
RP   SER-637; PHE-750; ILE-762; ASP-794; GLN-845; CYS-1016; ASN-1038; ILE-1169;
RP   LEU-1312; CYS-1356; SER-1389; VAL-1411; THR-1540; TYR-1549; ASN-1731;
RP   LEU-1810 AND GLN-1824.
RX   PubMed=17344846; DOI=10.1038/nature05610;
RA   Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G.,
RA   Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S.,
RA   Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.,
RA   Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K.,
RA   Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D.,
RA   Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R.,
RA   Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A.,
RA   Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F.,
RA   Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F.,
RA   Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G.,
RA   Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R.,
RA   Futreal P.A., Stratton M.R.;
RT   "Patterns of somatic mutation in human cancer genomes.";
RL   Nature 446:153-158(2007).
CC   -!- FUNCTION: May act as a functional substitute for TAF1/TAFII250 during
CC       male meiosis, when sex chromosomes are transcriptionally silenced.
CC       {ECO:0000269|PubMed:12217962}.
CC   -!- SUBUNIT: Can bind directly to TATA-box binding protein (TBP). Interacts
CC       (via bromo domains) with acetylated lysine residues on the N-terminus
CC       of histone H1.4, H2A, H2B, H3 and H4 (in vitro).
CC       {ECO:0000269|PubMed:12217962, ECO:0000269|PubMed:22464331}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Testis specific, expressed apparently in germ
CC       cells.
CC   -!- SIMILARITY: Belongs to the TAF1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF390562; AAN40840.1; -; mRNA.
DR   CCDS; CCDS35003.1; -.
DR   RefSeq; NP_722516.1; NM_153809.2.
DR   PDB; 3HMH; X-ray; 2.05 A; A=1523-1654.
DR   PDB; 5IGL; X-ray; 2.10 A; A=1523-1654.
DR   PDBsum; 3HMH; -.
DR   PDBsum; 5IGL; -.
DR   AlphaFoldDB; Q8IZX4; -.
DR   SMR; Q8IZX4; -.
DR   BioGRID; 126514; 20.
DR   IntAct; Q8IZX4; 7.
DR   MINT; Q8IZX4; -.
DR   STRING; 9606.ENSP00000418379; -.
DR   BindingDB; Q8IZX4; -.
DR   ChEMBL; CHEMBL3108641; -.
DR   iPTMnet; Q8IZX4; -.
DR   PhosphoSitePlus; Q8IZX4; -.
DR   BioMuta; TAF1L; -.
DR   DMDM; 57013082; -.
DR   EPD; Q8IZX4; -.
DR   jPOST; Q8IZX4; -.
DR   MassIVE; Q8IZX4; -.
DR   MaxQB; Q8IZX4; -.
DR   PaxDb; 9606-ENSP00000418379; -.
DR   PeptideAtlas; Q8IZX4; -.
DR   ProteomicsDB; 71440; -.
DR   Pumba; Q8IZX4; -.
DR   Antibodypedia; 25077; 83 antibodies from 22 providers.
DR   DNASU; 138474; -.
DR   Ensembl; ENST00000242310.4; ENSP00000418379.1; ENSG00000122728.6.
DR   GeneID; 138474; -.
DR   KEGG; hsa:138474; -.
DR   MANE-Select; ENST00000242310.4; ENSP00000418379.1; NM_153809.2; NP_722516.1.
DR   UCSC; uc003zrg.1; human.
DR   AGR; HGNC:18056; -.
DR   CTD; 138474; -.
DR   DisGeNET; 138474; -.
DR   GeneCards; TAF1L; -.
DR   HGNC; HGNC:18056; TAF1L.
DR   HPA; ENSG00000122728; Group enriched (retina, testis).
DR   MIM; 607798; gene.
DR   neXtProt; NX_Q8IZX4; -.
DR   OpenTargets; ENSG00000122728; -.
DR   PharmGKB; PA134947802; -.
DR   VEuPathDB; HostDB:ENSG00000122728; -.
DR   eggNOG; KOG0008; Eukaryota.
DR   GeneTree; ENSGT00940000155242; -.
DR   HOGENOM; CLU_000572_3_0_1; -.
DR   InParanoid; Q8IZX4; -.
DR   OMA; QLHWEDS; -.
DR   OrthoDB; 5482320at2759; -.
DR   PhylomeDB; Q8IZX4; -.
DR   TreeFam; TF313573; -.
DR   PathwayCommons; Q8IZX4; -.
DR   Reactome; R-HSA-167161; HIV Transcription Initiation.
DR   Reactome; R-HSA-167162; RNA Polymerase II HIV Promoter Escape.
DR   Reactome; R-HSA-167172; Transcription of the HIV genome.
DR   Reactome; R-HSA-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-HSA-6804756; Regulation of TP53 Activity through Phosphorylation.
DR   Reactome; R-HSA-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-HSA-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR   Reactome; R-HSA-75953; RNA Polymerase II Transcription Initiation.
DR   Reactome; R-HSA-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR   SignaLink; Q8IZX4; -.
DR   BioGRID-ORCS; 138474; 16 hits in 1147 CRISPR screens.
DR   EvolutionaryTrace; Q8IZX4; -.
DR   GenomeRNAi; 138474; -.
DR   Pharos; Q8IZX4; Tchem.
DR   PRO; PR:Q8IZX4; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8IZX4; Protein.
DR   Bgee; ENSG00000122728; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 9 other cell types or tissues.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004402; F:histone acetyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0070577; F:lysine-acetylated histone binding; IDA:UniProtKB.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0001091; F:RNA polymerase II general transcription initiation factor binding; IEA:InterPro.
DR   GO; GO:0017025; F:TBP-class protein binding; IPI:UniProtKB.
DR   GO; GO:0007140; P:male meiotic nuclear division; IEP:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IDA:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR   CDD; cd05511; Bromo_TFIID; 2.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR   Gene3D; 1.10.1100.10; TAFII-230 TBP-binding domain; 1.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR040240; TAF1.
DR   InterPro; IPR011177; TAF1_animal.
DR   InterPro; IPR022591; TAF1_HAT_dom.
DR   InterPro; IPR009067; TAF_II_230-bd.
DR   InterPro; IPR036741; TAFII-230_TBP-bd_sf.
DR   InterPro; IPR041670; Znf-CCHC_6.
DR   PANTHER; PTHR13900; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR   PANTHER; PTHR13900:SF2; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1-LIKE; 1.
DR   Pfam; PF00439; Bromodomain; 2.
DR   Pfam; PF12157; DUF3591; 1.
DR   Pfam; PF09247; TBP-binding; 1.
DR   Pfam; PF15288; zf-CCHC_6; 1.
DR   PIRSF; PIRSF003047; TAF1_animal; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 2.
DR   SUPFAM; SSF47370; Bromodomain; 2.
DR   SUPFAM; SSF47055; TAF(II)230 TBP-binding fragment; 1.
DR   PROSITE; PS00633; BROMODOMAIN_1; 2.
DR   PROSITE; PS50014; BROMODOMAIN_2; 2.
DR   Genevisible; Q8IZX4; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Bromodomain; Cell cycle; DNA-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..1826
FT                   /note="Transcription initiation factor TFIID subunit 1-
FT                   like"
FT                   /id="PRO_0000211217"
FT   DOMAIN          1416..1486
FT                   /note="Bromo 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT   DOMAIN          1539..1609
FT                   /note="Bromo 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT   REGION          118..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1252..1276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1648..1826
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           1370..1377
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1664..1704
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1765..1781
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         47
FT                   /note="G -> A (in a lung small cell carcinoma sample;
FT                   somatic mutation)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041934"
FT   VARIANT         171
FT                   /note="Q -> E (in dbSNP:rs56352331)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041935"
FT   VARIANT         256
FT                   /note="G -> A (in dbSNP:rs55991718)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041936"
FT   VARIANT         371
FT                   /note="M -> V (in dbSNP:rs17219559)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041937"
FT   VARIANT         532
FT                   /note="I -> N (in dbSNP:rs56128445)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041938"
FT   VARIANT         637
FT                   /note="P -> S (in dbSNP:rs56157814)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041939"
FT   VARIANT         750
FT                   /note="L -> F (in a lung adenocarcinoma sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041940"
FT   VARIANT         762
FT                   /note="L -> I (in a lung adenocarcinoma sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041941"
FT   VARIANT         794
FT                   /note="E -> D (in a lung adenocarcinoma sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041942"
FT   VARIANT         845
FT                   /note="R -> Q (in dbSNP:rs34787787)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041943"
FT   VARIANT         1016
FT                   /note="R -> C (in dbSNP:rs35905429)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041944"
FT   VARIANT         1038
FT                   /note="K -> N (in dbSNP:rs55767137)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041945"
FT   VARIANT         1169
FT                   /note="T -> I (in dbSNP:rs55976674)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041946"
FT   VARIANT         1312
FT                   /note="V -> L (in dbSNP:rs55824107)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041947"
FT   VARIANT         1356
FT                   /note="R -> C (in dbSNP:rs56107531)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041948"
FT   VARIANT         1389
FT                   /note="P -> S (in dbSNP:rs56393725)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041949"
FT   VARIANT         1411
FT                   /note="I -> V (in dbSNP:rs34500740)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041950"
FT   VARIANT         1540
FT                   /note="A -> T (in dbSNP:rs55782058)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041951"
FT   VARIANT         1549
FT                   /note="H -> Y (in a glioblastoma multiforme sample; somatic
FT                   mutation; dbSNP:rs1587670372)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041952"
FT   VARIANT         1731
FT                   /note="K -> N (in dbSNP:rs34241003)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041953"
FT   VARIANT         1805
FT                   /note="I -> V (in dbSNP:rs16918393)"
FT                   /id="VAR_048435"
FT   VARIANT         1810
FT                   /note="P -> L (in dbSNP:rs56342342)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041954"
FT   VARIANT         1824
FT                   /note="H -> Q (in a lung adenocarcinoma sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:17344846"
FT                   /id="VAR_041955"
FT   HELIX           1523..1536
FT                   /evidence="ECO:0007829|PDB:3HMH"
FT   TURN            1537..1540
FT                   /evidence="ECO:0007829|PDB:3HMH"
FT   HELIX           1545..1547
FT                   /evidence="ECO:0007829|PDB:3HMH"
FT   TURN            1553..1555
FT                   /evidence="ECO:0007829|PDB:3HMH"
FT   HELIX           1557..1562
FT                   /evidence="ECO:0007829|PDB:3HMH"
FT   HELIX           1569..1577
FT                   /evidence="ECO:0007829|PDB:3HMH"
FT   HELIX           1584..1602
FT                   /evidence="ECO:0007829|PDB:3HMH"
FT   HELIX           1607..1625
FT                   /evidence="ECO:0007829|PDB:3HMH"
FT   HELIX           1627..1649
FT                   /evidence="ECO:0007829|PDB:3HMH"
SQ   SEQUENCE   1826 AA;  207302 MW;  35D780E749AC9B17 CRC64;
     MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ LEGESVLDDE
     CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI RSTEDAVDYS DINEVAEDES
     QRHQQTMGSL QPLYHSDYDE DDYDADCEDI DCKLMPPPPP PPGPMKKDKD QDAITCVSES
     GEDIILPSII APSFLASEKV DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT
     KLLPSVTELF PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS
     VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV TDTKPRVAEW
     RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM MEEFRKLEES NGTDLLADEN
     FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD
     KPWYSIFPID NEDLVYGRWE DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT
     SNSPSKESKK ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR
     GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP GPHSVQPLLK
     HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA EYSEENGPLM MQVGMATKIK
     NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL GSLHPGQLLQ ALENNLFRAP VYLHKMPETD
     FLIIRTRQGY YIRELVDIFV VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR
     PRRIRMEDIK KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS
     PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP WNTTRAFIAA
     MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP QAVKKTVTGT DADLRRLSLK
     NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT MSTEQAHSGE GPMSKFARGS RFSVAEHQER
     YKEECQRIFD LQNKVLSSTE VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW
     EEQERKELRR MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR
     CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL RRLKRNQEKE
     KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL YYQTNVPPSK PVAMTEEQEE
     ELEKTVIHND NEELIKVEGT KIVFGKQLIE NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT
     VHCDYLNIPH KSIHRRRTDP MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII
     TRPMDLQTLR ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL
     KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP VNKKFVPDYY
     KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK YNGPESQYTK TAQEIVNICY
     QTITEYDEHL TQLEKDICTA KEAALEEAEL ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD
     ASVFQDESNL SVLDISTATP EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG
     DGDLADEEEG TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV
     GYGGIRPKQP FMLQHASGEH KDGHGK
//