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Q8IZX4 (TAF1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription initiation factor TFIID subunit 1-like
Alternative name(s):
TAF(II)210
TBP-associated factor 1-like
TBP-associated factor 210 kDa
Transcription initiation factor TFIID 210 kDa subunit
Gene names
Name:TAF1L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1826 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. Ref.1

Subunit structure

Can bind directly to TATA-box binding protein (TBP). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro). Ref.1 Ref.2

Subcellular location

Nucleus By similarity.

Tissue specificity

Testis specific, expressed apparently in germ cells.

Sequence similarities

Belongs to the TAF1 family.

Contains 2 bromo domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18261826Transcription initiation factor TFIID subunit 1-like
PRO_0000211217

Regions

Domain1416 – 148671Bromo 1
Domain1539 – 160971Bromo 2
Motif1370 – 13778Nuclear localization signal Potential
Compositional bias156 – 1649Pro-rich

Amino acid modifications

Disulfide bond1383 ↔ 1638 By similarity

Natural variations

Natural variant471G → A in a lung small cell carcinoma sample; somatic mutation. Ref.3
VAR_041934
Natural variant1711Q → E. Ref.3
Corresponds to variant rs56352331 [ dbSNP | Ensembl ].
VAR_041935
Natural variant2561G → A. Ref.3
Corresponds to variant rs55991718 [ dbSNP | Ensembl ].
VAR_041936
Natural variant3711M → V. Ref.3
Corresponds to variant rs17219559 [ dbSNP | Ensembl ].
VAR_041937
Natural variant5321I → N. Ref.3
Corresponds to variant rs56128445 [ dbSNP | Ensembl ].
VAR_041938
Natural variant6371P → S. Ref.3
Corresponds to variant rs56157814 [ dbSNP | Ensembl ].
VAR_041939
Natural variant7501L → F in a lung adenocarcinoma sample; somatic mutation. Ref.3
VAR_041940
Natural variant7621L → I in a lung adenocarcinoma sample; somatic mutation. Ref.3
VAR_041941
Natural variant7941E → D in a lung adenocarcinoma sample; somatic mutation. Ref.3
VAR_041942
Natural variant8201M → T.
Corresponds to variant rs1258 [ dbSNP | Ensembl ].
VAR_048434
Natural variant8451R → Q. Ref.3
Corresponds to variant rs34787787 [ dbSNP | Ensembl ].
VAR_041943
Natural variant10161R → C. Ref.3
Corresponds to variant rs35905429 [ dbSNP | Ensembl ].
VAR_041944
Natural variant10381K → N. Ref.3
Corresponds to variant rs55767137 [ dbSNP | Ensembl ].
VAR_041945
Natural variant11691T → I. Ref.3
Corresponds to variant rs55976674 [ dbSNP | Ensembl ].
VAR_041946
Natural variant13121V → L. Ref.3
Corresponds to variant rs55824107 [ dbSNP | Ensembl ].
VAR_041947
Natural variant13561R → C. Ref.3
Corresponds to variant rs56107531 [ dbSNP | Ensembl ].
VAR_041948
Natural variant13891P → S. Ref.3
Corresponds to variant rs56393725 [ dbSNP | Ensembl ].
VAR_041949
Natural variant14111I → V. Ref.3
Corresponds to variant rs34500740 [ dbSNP | Ensembl ].
VAR_041950
Natural variant15401A → T. Ref.3
Corresponds to variant rs55782058 [ dbSNP | Ensembl ].
VAR_041951
Natural variant15491H → Y in a glioblastoma multiforme sample; somatic mutation. Ref.3
VAR_041952
Natural variant17311K → N. Ref.3
Corresponds to variant rs34241003 [ dbSNP | Ensembl ].
VAR_041953
Natural variant18051I → V.
Corresponds to variant rs16918393 [ dbSNP | Ensembl ].
VAR_048435
Natural variant18101P → L. Ref.3
Corresponds to variant rs56342342 [ dbSNP | Ensembl ].
VAR_041954
Natural variant18241H → Q in a lung adenocarcinoma sample; somatic mutation. Ref.3
VAR_041955

Secondary structure

.................. 1826
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8IZX4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 35D780E749AC9B17

FASTA1,826207,302
        10         20         30         40         50         60 
MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ LEGESVLDDE 

        70         80         90        100        110        120 
CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI RSTEDAVDYS DINEVAEDES 

       130        140        150        160        170        180 
QRHQQTMGSL QPLYHSDYDE DDYDADCEDI DCKLMPPPPP PPGPMKKDKD QDAITCVSES 

       190        200        210        220        230        240 
GEDIILPSII APSFLASEKV DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT 

       250        260        270        280        290        300 
KLLPSVTELF PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS 

       310        320        330        340        350        360 
VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV TDTKPRVAEW 

       370        380        390        400        410        420 
RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM MEEFRKLEES NGTDLLADEN 

       430        440        450        460        470        480 
FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD 

       490        500        510        520        530        540 
KPWYSIFPID NEDLVYGRWE DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT 

       550        560        570        580        590        600 
SNSPSKESKK ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR 

       610        620        630        640        650        660 
GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP GPHSVQPLLK 

       670        680        690        700        710        720 
HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA EYSEENGPLM MQVGMATKIK 

       730        740        750        760        770        780 
NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL GSLHPGQLLQ ALENNLFRAP VYLHKMPETD 

       790        800        810        820        830        840 
FLIIRTRQGY YIRELVDIFV VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR 

       850        860        870        880        890        900 
PRRIRMEDIK KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS 

       910        920        930        940        950        960 
PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP WNTTRAFIAA 

       970        980        990       1000       1010       1020 
MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP QAVKKTVTGT DADLRRLSLK 

      1030       1040       1050       1060       1070       1080 
NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT MSTEQAHSGE GPMSKFARGS RFSVAEHQER 

      1090       1100       1110       1120       1130       1140 
YKEECQRIFD LQNKVLSSTE VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW 

      1150       1160       1170       1180       1190       1200 
EEQERKELRR MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR 

      1210       1220       1230       1240       1250       1260 
CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL RRLKRNQEKE 

      1270       1280       1290       1300       1310       1320 
KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL YYQTNVPPSK PVAMTEEQEE 

      1330       1340       1350       1360       1370       1380 
ELEKTVIHND NEELIKVEGT KIVFGKQLIE NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT 

      1390       1400       1410       1420       1430       1440 
VHCDYLNIPH KSIHRRRTDP MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII 

      1450       1460       1470       1480       1490       1500 
TRPMDLQTLR ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL 

      1510       1520       1530       1540       1550       1560 
KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP VNKKFVPDYY 

      1570       1580       1590       1600       1610       1620 
KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK YNGPESQYTK TAQEIVNICY 

      1630       1640       1650       1660       1670       1680 
QTITEYDEHL TQLEKDICTA KEAALEEAEL ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD 

      1690       1700       1710       1720       1730       1740 
ASVFQDESNL SVLDISTATP EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG 

      1750       1760       1770       1780       1790       1800 
DGDLADEEEG TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV 

      1810       1820 
GYGGIRPKQP FMLQHASGEH KDGHGK 

« Hide

References

« Hide 'large scale' references
[1]"Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis."
Wang P.J., Page D.C.
Hum. Mol. Genet. 11:2341-2346(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TBP.
Tissue: Testis.
[2]"Histone recognition and large-scale structural analysis of the human bromodomain family."
Filippakopoulos P., Picaud S., Mangos M., Keates T., Lambert J.P., Barsyte-Lovejoy D., Felletar I., Volkmer R., Muller S., Pawson T., Gingras A.C., Arrowsmith C.H., Knapp S.
Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1523-1654, SUBUNIT.
[3]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-47; GLU-171; ALA-256; VAL-371; ASN-532; SER-637; PHE-750; ILE-762; ASP-794; GLN-845; CYS-1016; ASN-1038; ILE-1169; LEU-1312; CYS-1356; SER-1389; VAL-1411; THR-1540; TYR-1549; ASN-1731; LEU-1810 AND GLN-1824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF390562 mRNA. Translation: AAN40840.1.
CCDSCCDS35003.1.
RefSeqNP_722516.1. NM_153809.2.
UniGeneHs.591086.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3HMHX-ray2.05A1523-1654[»]
ProteinModelPortalQ8IZX4.
SMRQ8IZX4. Positions 1396-1641.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126514. 9 interactions.
IntActQ8IZX4. 2 interactions.
MINTMINT-2810023.
STRING9606.ENSP00000418379.

PTM databases

PhosphoSiteQ8IZX4.

Polymorphism databases

DMDM57013082.

Proteomic databases

MaxQBQ8IZX4.
PaxDbQ8IZX4.
PRIDEQ8IZX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000242310; ENSP00000418379; ENSG00000122728.
GeneID138474.
KEGGhsa:138474.
UCSCuc003zrg.1. human.

Organism-specific databases

CTD138474.
GeneCardsGC09M032619.
H-InvDBHIX0169078.
HGNCHGNC:18056. TAF1L.
HPAHPA056605.
MIM607798. gene.
neXtProtNX_Q8IZX4.
PharmGKBPA134947802.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5076.
HOGENOMHOG000020066.
HOVERGENHBG050223.
InParanoidQ8IZX4.
KOK03125.
OMAVIREEPQ.
OrthoDBEOG7QNVK2.
PhylomeDBQ8IZX4.
TreeFamTF313573.

Gene expression databases

CleanExHS_TAF1L.
GenevestigatorQ8IZX4.

Family and domain databases

Gene3D1.10.1100.10. 1 hit.
1.20.920.10. 2 hits.
InterProIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view]
PfamPF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view]
PIRSFPIRSF003047. TAF1_animal. 1 hit.
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMSSF47055. SSF47055. 1 hit.
SSF47370. SSF47370. 2 hits.
PROSITEPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8IZX4.
GenomeRNAi138474.
NextBio83796.
PROQ8IZX4.
SOURCESearch...

Entry information

Entry nameTAF1L_HUMAN
AccessionPrimary (citable) accession number: Q8IZX4
Secondary accession number(s): Q0VG57
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM