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Protein

Transcription initiation factor TFIID subunit 1-like

Gene

TAF1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.1 Publication

GO - Molecular functioni

  • histone acetyltransferase activity Source: UniProtKB
  • lysine-acetylated histone binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly Source: GO_Central
  • sequence-specific DNA binding Source: GO_Central
  • TBP-class protein binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31936-MONOMER.
ReactomeiR-HSA-167161. HIV Transcription Initiation.
R-HSA-167162. RNA Polymerase II HIV Promoter Escape.
R-HSA-167172. Transcription of the HIV genome.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-73776. RNA Polymerase II Promoter Escape.
R-HSA-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-HSA-75953. RNA Polymerase II Transcription Initiation.
R-HSA-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1-like
Alternative name(s):
TAF(II)210
TBP-associated factor 1-like
TBP-associated factor 210 kDa
Transcription initiation factor TFIID 210 kDa subunit
Gene namesi
Name:TAF1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:18056. TAF1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122728.
PharmGKBiPA134947802.

Chemistry databases

ChEMBLiCHEMBL3108641.

Polymorphism and mutation databases

BioMutaiTAF1L.
DMDMi57013082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112171 – 1826Transcription initiation factor TFIID subunit 1-likeAdd BLAST1826

Proteomic databases

EPDiQ8IZX4.
MaxQBiQ8IZX4.
PaxDbiQ8IZX4.
PeptideAtlasiQ8IZX4.
PRIDEiQ8IZX4.

PTM databases

iPTMnetiQ8IZX4.
PhosphoSitePlusiQ8IZX4.

Expressioni

Tissue specificityi

Testis specific, expressed apparently in germ cells.

Gene expression databases

CleanExiHS_TAF1L.
GenevisibleiQ8IZX4. HS.

Organism-specific databases

HPAiHPA056605.

Interactioni

Subunit structurei

Can bind directly to TATA-box binding protein (TBP). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro).2 Publications

GO - Molecular functioni

  • lysine-acetylated histone binding Source: UniProtKB
  • TBP-class protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126514. 9 interactors.
IntActiQ8IZX4. 2 interactors.
MINTiMINT-2810023.
STRINGi9606.ENSP00000418379.

Chemistry databases

BindingDBiQ8IZX4.

Structurei

Secondary structure

11826
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1523 – 1536Combined sources14
Turni1537 – 1540Combined sources4
Helixi1545 – 1547Combined sources3
Turni1553 – 1555Combined sources3
Helixi1557 – 1562Combined sources6
Helixi1569 – 1577Combined sources9
Helixi1584 – 1602Combined sources19
Helixi1607 – 1625Combined sources19
Helixi1627 – 1649Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HMHX-ray2.05A1523-1654[»]
5IGLX-ray2.10A1523-1654[»]
ProteinModelPortaliQ8IZX4.
SMRiQ8IZX4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IZX4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1416 – 1486Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1539 – 1609Bromo 2PROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1370 – 1377Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 164Pro-rich9

Sequence similaritiesi

Belongs to the TAF1 family.Curated
Contains 2 bromo domains.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiKOG0008. Eukaryota.
COG5076. LUCA.
COG5179. LUCA.
GeneTreeiENSGT00390000012659.
HOGENOMiHOG000020066.
HOVERGENiHBG050223.
InParanoidiQ8IZX4.
KOiK03125.
OMAiVIREEPQ.
OrthoDBiEOG091G00MO.
PhylomeDBiQ8IZX4.
TreeFamiTF313573.

Family and domain databases

Gene3Di1.10.1100.10. 1 hit.
1.20.920.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF003047. TAF1_animal. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47055. SSF47055. 1 hit.
SSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ
60 70 80 90 100
LEGESVLDDE CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI
110 120 130 140 150
RSTEDAVDYS DINEVAEDES QRHQQTMGSL QPLYHSDYDE DDYDADCEDI
160 170 180 190 200
DCKLMPPPPP PPGPMKKDKD QDAITCVSES GEDIILPSII APSFLASEKV
210 220 230 240 250
DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT KLLPSVTELF
260 270 280 290 300
PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS
310 320 330 340 350
VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV
360 370 380 390 400
TDTKPRVAEW RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM
410 420 430 440 450
MEEFRKLEES NGTDLLADEN FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA
460 470 480 490 500
SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD KPWYSIFPID NEDLVYGRWE
510 520 530 540 550
DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT SNSPSKESKK
560 570 580 590 600
ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR
610 620 630 640 650
GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP
660 670 680 690 700
GPHSVQPLLK HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA
710 720 730 740 750
EYSEENGPLM MQVGMATKIK NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL
760 770 780 790 800
GSLHPGQLLQ ALENNLFRAP VYLHKMPETD FLIIRTRQGY YIRELVDIFV
810 820 830 840 850
VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR PRRIRMEDIK
860 870 880 890 900
KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS
910 920 930 940 950
PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP
960 970 980 990 1000
WNTTRAFIAA MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP
1010 1020 1030 1040 1050
QAVKKTVTGT DADLRRLSLK NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT
1060 1070 1080 1090 1100
MSTEQAHSGE GPMSKFARGS RFSVAEHQER YKEECQRIFD LQNKVLSSTE
1110 1120 1130 1140 1150
VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW EEQERKELRR
1160 1170 1180 1190 1200
MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR
1210 1220 1230 1240 1250
CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL
1260 1270 1280 1290 1300
RRLKRNQEKE KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL
1310 1320 1330 1340 1350
YYQTNVPPSK PVAMTEEQEE ELEKTVIHND NEELIKVEGT KIVFGKQLIE
1360 1370 1380 1390 1400
NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT VHCDYLNIPH KSIHRRRTDP
1410 1420 1430 1440 1450
MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII TRPMDLQTLR
1460 1470 1480 1490 1500
ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL
1510 1520 1530 1540 1550
KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP
1560 1570 1580 1590 1600
VNKKFVPDYY KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK
1610 1620 1630 1640 1650
YNGPESQYTK TAQEIVNICY QTITEYDEHL TQLEKDICTA KEAALEEAEL
1660 1670 1680 1690 1700
ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD ASVFQDESNL SVLDISTATP
1710 1720 1730 1740 1750
EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG DGDLADEEEG
1760 1770 1780 1790 1800
TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV
1810 1820
GYGGIRPKQP FMLQHASGEH KDGHGK
Length:1,826
Mass (Da):207,302
Last modified:March 1, 2003 - v1
Checksum:i35D780E749AC9B17
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04193447G → A in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041935171Q → E.1 PublicationCorresponds to variant rs56352331dbSNPEnsembl.1
Natural variantiVAR_041936256G → A.1 PublicationCorresponds to variant rs55991718dbSNPEnsembl.1
Natural variantiVAR_041937371M → V.1 PublicationCorresponds to variant rs17219559dbSNPEnsembl.1
Natural variantiVAR_041938532I → N.1 PublicationCorresponds to variant rs56128445dbSNPEnsembl.1
Natural variantiVAR_041939637P → S.1 PublicationCorresponds to variant rs56157814dbSNPEnsembl.1
Natural variantiVAR_041940750L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041941762L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041942794E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041943845R → Q.1 PublicationCorresponds to variant rs34787787dbSNPEnsembl.1
Natural variantiVAR_0419441016R → C.1 PublicationCorresponds to variant rs35905429dbSNPEnsembl.1
Natural variantiVAR_0419451038K → N.1 PublicationCorresponds to variant rs55767137dbSNPEnsembl.1
Natural variantiVAR_0419461169T → I.1 PublicationCorresponds to variant rs55976674dbSNPEnsembl.1
Natural variantiVAR_0419471312V → L.1 PublicationCorresponds to variant rs55824107dbSNPEnsembl.1
Natural variantiVAR_0419481356R → C.1 PublicationCorresponds to variant rs56107531dbSNPEnsembl.1
Natural variantiVAR_0419491389P → S.1 PublicationCorresponds to variant rs56393725dbSNPEnsembl.1
Natural variantiVAR_0419501411I → V.1 PublicationCorresponds to variant rs34500740dbSNPEnsembl.1
Natural variantiVAR_0419511540A → T.1 PublicationCorresponds to variant rs55782058dbSNPEnsembl.1
Natural variantiVAR_0419521549H → Y in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_0419531731K → N.1 PublicationCorresponds to variant rs34241003dbSNPEnsembl.1
Natural variantiVAR_0484351805I → V.Corresponds to variant rs16918393dbSNPEnsembl.1
Natural variantiVAR_0419541810P → L.1 PublicationCorresponds to variant rs56342342dbSNPEnsembl.1
Natural variantiVAR_0419551824H → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390562 mRNA. Translation: AAN40840.1.
CCDSiCCDS35003.1.
RefSeqiNP_722516.1. NM_153809.2.
UniGeneiHs.591086.

Genome annotation databases

EnsembliENST00000242310; ENSP00000418379; ENSG00000122728.
GeneIDi138474.
KEGGihsa:138474.
UCSCiuc003zrg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390562 mRNA. Translation: AAN40840.1.
CCDSiCCDS35003.1.
RefSeqiNP_722516.1. NM_153809.2.
UniGeneiHs.591086.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HMHX-ray2.05A1523-1654[»]
5IGLX-ray2.10A1523-1654[»]
ProteinModelPortaliQ8IZX4.
SMRiQ8IZX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126514. 9 interactors.
IntActiQ8IZX4. 2 interactors.
MINTiMINT-2810023.
STRINGi9606.ENSP00000418379.

Chemistry databases

BindingDBiQ8IZX4.
ChEMBLiCHEMBL3108641.

PTM databases

iPTMnetiQ8IZX4.
PhosphoSitePlusiQ8IZX4.

Polymorphism and mutation databases

BioMutaiTAF1L.
DMDMi57013082.

Proteomic databases

EPDiQ8IZX4.
MaxQBiQ8IZX4.
PaxDbiQ8IZX4.
PeptideAtlasiQ8IZX4.
PRIDEiQ8IZX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242310; ENSP00000418379; ENSG00000122728.
GeneIDi138474.
KEGGihsa:138474.
UCSCiuc003zrg.1. human.

Organism-specific databases

CTDi138474.
GeneCardsiTAF1L.
H-InvDBHIX0169078.
HGNCiHGNC:18056. TAF1L.
HPAiHPA056605.
MIMi607798. gene.
neXtProtiNX_Q8IZX4.
OpenTargetsiENSG00000122728.
PharmGKBiPA134947802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0008. Eukaryota.
COG5076. LUCA.
COG5179. LUCA.
GeneTreeiENSGT00390000012659.
HOGENOMiHOG000020066.
HOVERGENiHBG050223.
InParanoidiQ8IZX4.
KOiK03125.
OMAiVIREEPQ.
OrthoDBiEOG091G00MO.
PhylomeDBiQ8IZX4.
TreeFamiTF313573.

Enzyme and pathway databases

BioCyciZFISH:G66-31936-MONOMER.
ReactomeiR-HSA-167161. HIV Transcription Initiation.
R-HSA-167162. RNA Polymerase II HIV Promoter Escape.
R-HSA-167172. Transcription of the HIV genome.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-HSA-73776. RNA Polymerase II Promoter Escape.
R-HSA-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-HSA-75953. RNA Polymerase II Transcription Initiation.
R-HSA-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

EvolutionaryTraceiQ8IZX4.
GenomeRNAii138474.
PROiQ8IZX4.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TAF1L.
GenevisibleiQ8IZX4. HS.

Family and domain databases

Gene3Di1.10.1100.10. 1 hit.
1.20.920.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF003047. TAF1_animal. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47055. SSF47055. 1 hit.
SSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAF1L_HUMAN
AccessioniPrimary (citable) accession number: Q8IZX4
Secondary accession number(s): Q0VG57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.