Q8IZX4 (TAF1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription initiation factor TFIID subunit 1-like

Alternative name(s):
TAF(II)210
TBP-associated factor 1-like
TBP-associated factor 210 kDa
Transcription initiation factor TFIID 210 kDa subunit

Gene names

Name:

TAF1L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1826 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. Ref.1
Subunit structure	Can bind directly to TATA-box binding protein (TBP).
Subcellular location	Nucleus By similarity.
Tissue specificity	Testis specific, expressed apparently in germ cells.
Sequence similarities	Belongs to the TAF1 family. Contains 2 bromo domains.

Ontologies

Keywords
Biological process	Cell cycle Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Bromodomain Repeat
Ligand	DNA-binding
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	male meiosis Inferred from expression pattern Ref.1. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.1. Source: UniProtKB regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.1. Source: UniProtKB transcription initiation, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	transcription factor TFIID complex Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW TBP-class protein binding Inferred from physical interaction Ref.1. Source: UniProtKB histone acetyltransferase activity Inferred from sequence or structural similarity Ref.1. Source: UniProtKB protein serine/threonine kinase activity Inferred from sequence or structural similarity Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1826

1826

Transcription initiation factor TFIID subunit 1-like

PRO_0000211217

Regions

Domain

1416 – 1486

71

Bromo 1

Domain

1539 – 1609

71

Bromo 2

Motif

1370 – 1377

8

Nuclear localization signal Potential

Compositional bias

156 – 164

9

Pro-rich

Amino acid modifications

Disulfide bond

1383 ↔ 1638

By similarity

Natural variations

Natural variant

47

1

G → A in a lung small cell carcinoma sample; somatic mutation. Ref.2

VAR_041934

Natural variant

171

1

Q → E. Ref.2

VAR_041935

Natural variant

256

1

G → A. Ref.2
Corresponds to variant rs55991718 [ dbSNP | Ensembl ].

VAR_041936

Natural variant

371

1

M → V. Ref.2
Corresponds to variant rs17219559 [ dbSNP | Ensembl ].

VAR_041937

Natural variant

532

1

I → N. Ref.2
Corresponds to variant rs56128445 [ dbSNP | Ensembl ].

VAR_041938

Natural variant

637

1

P → S. Ref.2
Corresponds to variant rs56157814 [ dbSNP | Ensembl ].

VAR_041939

Natural variant

750

1

L → F in a lung adenocarcinoma sample; somatic mutation. Ref.2

VAR_041940

Natural variant

762

1

L → I in a lung adenocarcinoma sample; somatic mutation. Ref.2

VAR_041941

Natural variant

794

1

E → D in a lung adenocarcinoma sample; somatic mutation. Ref.2

VAR_041942

Natural variant

820

1

M → T.
Corresponds to variant rs1258 [ dbSNP | Ensembl ].

VAR_048434

Natural variant

845

1

R → Q. Ref.2
Corresponds to variant rs34787787 [ dbSNP | Ensembl ].

VAR_041943

Natural variant

1016

1

R → C. Ref.2
Corresponds to variant rs35905429 [ dbSNP | Ensembl ].

VAR_041944

Natural variant

1038

1

K → N. Ref.2
Corresponds to variant rs55767137 [ dbSNP | Ensembl ].

VAR_041945

Natural variant

1169

1

T → I. Ref.2
Corresponds to variant rs55976674 [ dbSNP | Ensembl ].

VAR_041946

Natural variant

1312

1

V → L. Ref.2
Corresponds to variant rs55824107 [ dbSNP | Ensembl ].

VAR_041947

Natural variant

1356

1

R → C. Ref.2
Corresponds to variant rs56107531 [ dbSNP | Ensembl ].

VAR_041948

Natural variant

1389

1

P → S. Ref.2
Corresponds to variant rs56393725 [ dbSNP | Ensembl ].

VAR_041949

Natural variant

1411

1

I → V. Ref.2
Corresponds to variant rs34500740 [ dbSNP | Ensembl ].

VAR_041950

Natural variant

1540

1

A → T. Ref.2
Corresponds to variant rs55782058 [ dbSNP | Ensembl ].

VAR_041951

Natural variant

1549

1

H → Y in a glioblastoma multiforme sample; somatic mutation. Ref.2

VAR_041952

Natural variant

1731

1

K → N. Ref.2
Corresponds to variant rs34241003 [ dbSNP | Ensembl ].

VAR_041953

Natural variant

1805

1

I → V.
Corresponds to variant rs16918393 [ dbSNP | Ensembl ].

VAR_048435

Natural variant

1810

1

P → L. Ref.2
Corresponds to variant rs56342342 [ dbSNP | Ensembl ].

VAR_041954

Natural variant

1824

1

H → Q in a lung adenocarcinoma sample; somatic mutation. Ref.2

VAR_041955

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1826

Helix Strand Turn

Details...

Helix

1523 – 1536

14

Turn

1537 – 1540

4

Turn

1542 – 1544

3

Helix

1545 – 1547

3

Turn

1553 – 1555

3

Helix

1557 – 1562

6

Helix

1569 – 1577

9

Helix

1584 – 1601

18

Helix

1607 – 1625

19

Helix

1627 – 1649

23

Sequences

	Sequence		Length	Mass (Da)
	Q8IZX4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 35D780E749AC9B17	FASTA	1,826	207,302
	10 20 30 40 50 60 MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ LEGESVLDDE 70 80 90 100 110 120 CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI RSTEDAVDYS DINEVAEDES 130 140 150 160 170 180 QRHQQTMGSL QPLYHSDYDE DDYDADCEDI DCKLMPPPPP PPGPMKKDKD QDAITCVSES 190 200 210 220 230 240 GEDIILPSII APSFLASEKV DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT 250 260 270 280 290 300 KLLPSVTELF PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS 310 320 330 340 350 360 VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV TDTKPRVAEW 370 380 390 400 410 420 RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM MEEFRKLEES NGTDLLADEN 430 440 450 460 470 480 FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD 490 500 510 520 530 540 KPWYSIFPID NEDLVYGRWE DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT 550 560 570 580 590 600 SNSPSKESKK ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR 610 620 630 640 650 660 GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP GPHSVQPLLK 670 680 690 700 710 720 HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA EYSEENGPLM MQVGMATKIK 730 740 750 760 770 780 NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL GSLHPGQLLQ ALENNLFRAP VYLHKMPETD 790 800 810 820 830 840 FLIIRTRQGY YIRELVDIFV VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR 850 860 870 880 890 900 PRRIRMEDIK KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS 910 920 930 940 950 960 PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP WNTTRAFIAA 970 980 990 1000 1010 1020 MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP QAVKKTVTGT DADLRRLSLK 1030 1040 1050 1060 1070 1080 NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT MSTEQAHSGE GPMSKFARGS RFSVAEHQER 1090 1100 1110 1120 1130 1140 YKEECQRIFD LQNKVLSSTE VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW 1150 1160 1170 1180 1190 1200 EEQERKELRR MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR 1210 1220 1230 1240 1250 1260 CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL RRLKRNQEKE 1270 1280 1290 1300 1310 1320 KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL YYQTNVPPSK PVAMTEEQEE 1330 1340 1350 1360 1370 1380 ELEKTVIHND NEELIKVEGT KIVFGKQLIE NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT 1390 1400 1410 1420 1430 1440 VHCDYLNIPH KSIHRRRTDP MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII 1450 1460 1470 1480 1490 1500 TRPMDLQTLR ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL 1510 1520 1530 1540 1550 1560 KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP VNKKFVPDYY 1570 1580 1590 1600 1610 1620 KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK YNGPESQYTK TAQEIVNICY 1630 1640 1650 1660 1670 1680 QTITEYDEHL TQLEKDICTA KEAALEEAEL ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD 1690 1700 1710 1720 1730 1740 ASVFQDESNL SVLDISTATP EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG 1750 1760 1770 1780 1790 1800 DGDLADEEEG TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV 1810 1820 GYGGIRPKQP FMLQHASGEH KDGHGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis." Wang P.J., Page D.C. Hum. Mol. Genet. 11:2341-2346(2002) [PubMed: 12217962] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TBP. Tissue: Testis.
[2]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-47; GLU-171; ALA-256; VAL-371; ASN-532; SER-637; PHE-750; ILE-762; ASP-794; GLN-845; CYS-1016; ASN-1038; ILE-1169; LEU-1312; CYS-1356; SER-1389; VAL-1411; THR-1540; TYR-1549; ASN-1731; LEU-1810 AND GLN-1824.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF390562 mRNA. Translation: AAN40840.1.

IPI

IPI00100867.

RefSeq

NP_722516.1. NM_153809.2.

UniGene

Hs.591086.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3HMH	X-ray	2.05	A	1523-1654	[»]

ProteinModelPortal

Q8IZX4.

SMR

Q8IZX4. Positions 28-84, 1378-1644.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8IZX4. 1 interaction.

STRING

Q8IZX4.

Polymorphism databases

DMDM

57013082.

Proteomic databases

PRIDE

Q8IZX4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000242310; ENSP00000418379; ENSG00000122728.

GeneID

138474.

KEGG

hsa:138474.

NMPDR

fig|9606.3.peg.31136.

UCSC

uc003zrg.1. human.

Organism-specific databases

CTD

138474.

GeneCards

GC09M032619.

H-InvDB

HIX0034783.

HGNC

HGNC:18056. TAF1L.

MIM

607798. gene.

neXtProt

NX_Q8IZX4.

PharmGKB

PA134947802.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG16035.

GeneTree

ENSGT00390000012659.

HOGENOM

HBG378506.

HOVERGEN

HBG050223.

InParanoid

Q8IZX4.

OrthoDB

EOG4K3KVC.

PhylomeDB

Q8IZX4.

Gene expression databases

ArrayExpress

Q8IZX4.

CleanEx

HS_TAF1L.

Genevestigator

Q8IZX4.

GermOnline

ENSG00000122728. Homo sapiens.

Family and domain databases

InterPro

IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view]

Gene3D

G3DSA:1.20.920.10. Bromodomain. 2 hits.

KO

K03125.

Pfam

PF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view]

PIRSF

PIRSF003047. TAF1_animal. 1 hit.

PRINTS

PR00503. BROMODOMAIN.

SMART

SM00297. BROMO. 2 hits.
[Graphical view]

SUPFAM

SSF47370. Bromodomain. 2 hits.
SSF47055. TAF_II_230. 1 hit.

PROSITE

PS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

83796.

SOURCE

Search...

Entry information

Entry name

TAF1L_HUMAN

Accession

Primary (citable) accession number: Q8IZX4
Secondary accession number(s): Q0VG57

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.