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Q8IZX4

- TAF1L_HUMAN

UniProt

Q8IZX4 - TAF1L_HUMAN

Protein

Transcription initiation factor TFIID subunit 1-like

Gene

TAF1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. histone acetyltransferase activity Source: UniProtKB
    3. lysine-acetylated histone binding Source: UniProtKB
    4. protein serine/threonine kinase activity Source: UniProtKB
    5. TBP-class protein binding Source: UniProtKB

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: InterPro
    2. histone acetylation Source: GOC
    3. male meiosis Source: UniProtKB
    4. positive regulation of transcription, DNA-templated Source: UniProtKB
    5. protein phosphorylation Source: GOC
    6. regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor TFIID subunit 1-like
    Alternative name(s):
    TAF(II)210
    TBP-associated factor 1-like
    TBP-associated factor 210 kDa
    Transcription initiation factor TFIID 210 kDa subunit
    Gene namesi
    Name:TAF1L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18056. TAF1L.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. transcription factor TFIID complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134947802.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18261826Transcription initiation factor TFIID subunit 1-likePRO_0000211217Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi1383 ↔ 1638By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ8IZX4.
    PaxDbiQ8IZX4.
    PRIDEiQ8IZX4.

    PTM databases

    PhosphoSiteiQ8IZX4.

    Expressioni

    Tissue specificityi

    Testis specific, expressed apparently in germ cells.

    Gene expression databases

    CleanExiHS_TAF1L.
    GenevestigatoriQ8IZX4.

    Organism-specific databases

    HPAiHPA056605.

    Interactioni

    Subunit structurei

    Can bind directly to TATA-box binding protein (TBP). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro).2 Publications

    Protein-protein interaction databases

    BioGridi126514. 9 interactions.
    IntActiQ8IZX4. 2 interactions.
    MINTiMINT-2810023.
    STRINGi9606.ENSP00000418379.

    Structurei

    Secondary structure

    1
    1826
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1523 – 153614
    Turni1537 – 15404
    Helixi1545 – 15473
    Turni1553 – 15553
    Helixi1557 – 15626
    Helixi1569 – 15779
    Helixi1584 – 160219
    Helixi1607 – 162519
    Helixi1627 – 164923

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3HMHX-ray2.05A1523-1654[»]
    ProteinModelPortaliQ8IZX4.
    SMRiQ8IZX4. Positions 1396-1641.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8IZX4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1416 – 148671Bromo 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1539 – 160971Bromo 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1370 – 13778Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi156 – 1649Pro-rich

    Sequence similaritiesi

    Belongs to the TAF1 family.Curated
    Contains 2 bromo domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain, Repeat

    Phylogenomic databases

    eggNOGiCOG5076.
    HOGENOMiHOG000020066.
    HOVERGENiHBG050223.
    InParanoidiQ8IZX4.
    KOiK03125.
    OMAiVIREEPQ.
    OrthoDBiEOG7QNVK2.
    PhylomeDBiQ8IZX4.
    TreeFamiTF313573.

    Family and domain databases

    Gene3Di1.10.1100.10. 1 hit.
    1.20.920.10. 2 hits.
    InterProiIPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR011177. TAF1_animal.
    IPR009067. TAF_II_230-bd.
    IPR022591. TFIID_sub1_DUF3591.
    [Graphical view]
    PfamiPF00439. Bromodomain. 2 hits.
    PF12157. DUF3591. 1 hit.
    PF09247. TBP-binding. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003047. TAF1_animal. 1 hit.
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 2 hits.
    [Graphical view]
    SUPFAMiSSF47055. SSF47055. 1 hit.
    SSF47370. SSF47370. 2 hits.
    PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
    PS50014. BROMODOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IZX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ     50
    LEGESVLDDE CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI 100
    RSTEDAVDYS DINEVAEDES QRHQQTMGSL QPLYHSDYDE DDYDADCEDI 150
    DCKLMPPPPP PPGPMKKDKD QDAITCVSES GEDIILPSII APSFLASEKV 200
    DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT KLLPSVTELF 250
    PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS 300
    VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV 350
    TDTKPRVAEW RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM 400
    MEEFRKLEES NGTDLLADEN FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA 450
    SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD KPWYSIFPID NEDLVYGRWE 500
    DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT SNSPSKESKK 550
    ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR 600
    GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP 650
    GPHSVQPLLK HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA 700
    EYSEENGPLM MQVGMATKIK NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL 750
    GSLHPGQLLQ ALENNLFRAP VYLHKMPETD FLIIRTRQGY YIRELVDIFV 800
    VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR PRRIRMEDIK 850
    KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS 900
    PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP 950
    WNTTRAFIAA MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP 1000
    QAVKKTVTGT DADLRRLSLK NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT 1050
    MSTEQAHSGE GPMSKFARGS RFSVAEHQER YKEECQRIFD LQNKVLSSTE 1100
    VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW EEQERKELRR 1150
    MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR 1200
    CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL 1250
    RRLKRNQEKE KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL 1300
    YYQTNVPPSK PVAMTEEQEE ELEKTVIHND NEELIKVEGT KIVFGKQLIE 1350
    NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT VHCDYLNIPH KSIHRRRTDP 1400
    MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII TRPMDLQTLR 1450
    ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL 1500
    KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP 1550
    VNKKFVPDYY KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK 1600
    YNGPESQYTK TAQEIVNICY QTITEYDEHL TQLEKDICTA KEAALEEAEL 1650
    ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD ASVFQDESNL SVLDISTATP 1700
    EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG DGDLADEEEG 1750
    TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV 1800
    GYGGIRPKQP FMLQHASGEH KDGHGK 1826
    Length:1,826
    Mass (Da):207,302
    Last modified:March 1, 2003 - v1
    Checksum:i35D780E749AC9B17
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471G → A in a lung small cell carcinoma sample; somatic mutation. 1 Publication
    VAR_041934
    Natural varianti171 – 1711Q → E.1 Publication
    Corresponds to variant rs56352331 [ dbSNP | Ensembl ].
    VAR_041935
    Natural varianti256 – 2561G → A.1 Publication
    Corresponds to variant rs55991718 [ dbSNP | Ensembl ].
    VAR_041936
    Natural varianti371 – 3711M → V.1 Publication
    Corresponds to variant rs17219559 [ dbSNP | Ensembl ].
    VAR_041937
    Natural varianti532 – 5321I → N.1 Publication
    Corresponds to variant rs56128445 [ dbSNP | Ensembl ].
    VAR_041938
    Natural varianti637 – 6371P → S.1 Publication
    Corresponds to variant rs56157814 [ dbSNP | Ensembl ].
    VAR_041939
    Natural varianti750 – 7501L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041940
    Natural varianti762 – 7621L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041941
    Natural varianti794 – 7941E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041942
    Natural varianti820 – 8201M → T.
    Corresponds to variant rs1258 [ dbSNP | Ensembl ].
    VAR_048434
    Natural varianti845 – 8451R → Q.1 Publication
    Corresponds to variant rs34787787 [ dbSNP | Ensembl ].
    VAR_041943
    Natural varianti1016 – 10161R → C.1 Publication
    Corresponds to variant rs35905429 [ dbSNP | Ensembl ].
    VAR_041944
    Natural varianti1038 – 10381K → N.1 Publication
    Corresponds to variant rs55767137 [ dbSNP | Ensembl ].
    VAR_041945
    Natural varianti1169 – 11691T → I.1 Publication
    Corresponds to variant rs55976674 [ dbSNP | Ensembl ].
    VAR_041946
    Natural varianti1312 – 13121V → L.1 Publication
    Corresponds to variant rs55824107 [ dbSNP | Ensembl ].
    VAR_041947
    Natural varianti1356 – 13561R → C.1 Publication
    Corresponds to variant rs56107531 [ dbSNP | Ensembl ].
    VAR_041948
    Natural varianti1389 – 13891P → S.1 Publication
    Corresponds to variant rs56393725 [ dbSNP | Ensembl ].
    VAR_041949
    Natural varianti1411 – 14111I → V.1 Publication
    Corresponds to variant rs34500740 [ dbSNP | Ensembl ].
    VAR_041950
    Natural varianti1540 – 15401A → T.1 Publication
    Corresponds to variant rs55782058 [ dbSNP | Ensembl ].
    VAR_041951
    Natural varianti1549 – 15491H → Y in a glioblastoma multiforme sample; somatic mutation. 1 Publication
    VAR_041952
    Natural varianti1731 – 17311K → N.1 Publication
    Corresponds to variant rs34241003 [ dbSNP | Ensembl ].
    VAR_041953
    Natural varianti1805 – 18051I → V.
    Corresponds to variant rs16918393 [ dbSNP | Ensembl ].
    VAR_048435
    Natural varianti1810 – 18101P → L.1 Publication
    Corresponds to variant rs56342342 [ dbSNP | Ensembl ].
    VAR_041954
    Natural varianti1824 – 18241H → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041955

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF390562 mRNA. Translation: AAN40840.1.
    CCDSiCCDS35003.1.
    RefSeqiNP_722516.1. NM_153809.2.
    UniGeneiHs.591086.

    Genome annotation databases

    EnsembliENST00000242310; ENSP00000418379; ENSG00000122728.
    GeneIDi138474.
    KEGGihsa:138474.
    UCSCiuc003zrg.1. human.

    Polymorphism databases

    DMDMi57013082.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF390562 mRNA. Translation: AAN40840.1 .
    CCDSi CCDS35003.1.
    RefSeqi NP_722516.1. NM_153809.2.
    UniGenei Hs.591086.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3HMH X-ray 2.05 A 1523-1654 [» ]
    ProteinModelPortali Q8IZX4.
    SMRi Q8IZX4. Positions 1396-1641.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126514. 9 interactions.
    IntActi Q8IZX4. 2 interactions.
    MINTi MINT-2810023.
    STRINGi 9606.ENSP00000418379.

    PTM databases

    PhosphoSitei Q8IZX4.

    Polymorphism databases

    DMDMi 57013082.

    Proteomic databases

    MaxQBi Q8IZX4.
    PaxDbi Q8IZX4.
    PRIDEi Q8IZX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000242310 ; ENSP00000418379 ; ENSG00000122728 .
    GeneIDi 138474.
    KEGGi hsa:138474.
    UCSCi uc003zrg.1. human.

    Organism-specific databases

    CTDi 138474.
    GeneCardsi GC09M032619.
    H-InvDB HIX0169078.
    HGNCi HGNC:18056. TAF1L.
    HPAi HPA056605.
    MIMi 607798. gene.
    neXtProti NX_Q8IZX4.
    PharmGKBi PA134947802.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5076.
    HOGENOMi HOG000020066.
    HOVERGENi HBG050223.
    InParanoidi Q8IZX4.
    KOi K03125.
    OMAi VIREEPQ.
    OrthoDBi EOG7QNVK2.
    PhylomeDBi Q8IZX4.
    TreeFami TF313573.

    Miscellaneous databases

    EvolutionaryTracei Q8IZX4.
    GenomeRNAii 138474.
    NextBioi 83796.
    PROi Q8IZX4.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_TAF1L.
    Genevestigatori Q8IZX4.

    Family and domain databases

    Gene3Di 1.10.1100.10. 1 hit.
    1.20.920.10. 2 hits.
    InterProi IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR011177. TAF1_animal.
    IPR009067. TAF_II_230-bd.
    IPR022591. TFIID_sub1_DUF3591.
    [Graphical view ]
    Pfami PF00439. Bromodomain. 2 hits.
    PF12157. DUF3591. 1 hit.
    PF09247. TBP-binding. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003047. TAF1_animal. 1 hit.
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47055. SSF47055. 1 hit.
    SSF47370. SSF47370. 2 hits.
    PROSITEi PS00633. BROMODOMAIN_1. 2 hits.
    PS50014. BROMODOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis."
      Wang P.J., Page D.C.
      Hum. Mol. Genet. 11:2341-2346(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TBP.
      Tissue: Testis.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1523-1654, SUBUNIT.
    3. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-47; GLU-171; ALA-256; VAL-371; ASN-532; SER-637; PHE-750; ILE-762; ASP-794; GLN-845; CYS-1016; ASN-1038; ILE-1169; LEU-1312; CYS-1356; SER-1389; VAL-1411; THR-1540; TYR-1549; ASN-1731; LEU-1810 AND GLN-1824.

    Entry informationi

    Entry nameiTAF1L_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZX4
    Secondary accession number(s): Q0VG57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3