SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IZX4

- TAF1L_HUMAN

UniProt

Q8IZX4 - TAF1L_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Transcription initiation factor TFIID subunit 1-like
Gene
TAF1L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. TBP-class protein binding Source: UniProtKB
  3. histone acetyltransferase activity Source: UniProtKB
  4. lysine-acetylated histone binding Source: UniProtKB
  5. protein serine/threonine kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. DNA-templated transcription, initiation Source: InterPro
  2. histone acetylation Source: GOC
  3. male meiosis Source: UniProtKB
  4. positive regulation of transcription, DNA-templated Source: UniProtKB
  5. protein phosphorylation Source: GOC
  6. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1-like
Alternative name(s):
TAF(II)210
TBP-associated factor 1-like
TBP-associated factor 210 kDa
Transcription initiation factor TFIID 210 kDa subunit
Gene namesi
Name:TAF1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18056. TAF1L.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. transcription factor TFIID complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134947802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18261826Transcription initiation factor TFIID subunit 1-like
PRO_0000211217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1383 ↔ 1638 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8IZX4.
PaxDbiQ8IZX4.
PRIDEiQ8IZX4.

PTM databases

PhosphoSiteiQ8IZX4.

Expressioni

Tissue specificityi

Testis specific, expressed apparently in germ cells.

Gene expression databases

CleanExiHS_TAF1L.
GenevestigatoriQ8IZX4.

Organism-specific databases

HPAiHPA056605.

Interactioni

Subunit structurei

Can bind directly to TATA-box binding protein (TBP). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro).2 Publications

Protein-protein interaction databases

BioGridi126514. 9 interactions.
IntActiQ8IZX4. 2 interactions.
MINTiMINT-2810023.
STRINGi9606.ENSP00000418379.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1523 – 153614
Turni1537 – 15404
Helixi1545 – 15473
Turni1553 – 15553
Helixi1557 – 15626
Helixi1569 – 15779
Helixi1584 – 160219
Helixi1607 – 162519
Helixi1627 – 164923

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HMHX-ray2.05A1523-1654[»]
ProteinModelPortaliQ8IZX4.
SMRiQ8IZX4. Positions 1396-1641.

Miscellaneous databases

EvolutionaryTraceiQ8IZX4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1416 – 148671Bromo 1
Add
BLAST
Domaini1539 – 160971Bromo 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1370 – 13778Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1649Pro-rich

Sequence similaritiesi

Belongs to the TAF1 family.
Contains 2 bromo domains.

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000020066.
HOVERGENiHBG050223.
InParanoidiQ8IZX4.
KOiK03125.
OMAiVIREEPQ.
OrthoDBiEOG7QNVK2.
PhylomeDBiQ8IZX4.
TreeFamiTF313573.

Family and domain databases

Gene3Di1.10.1100.10. 1 hit.
1.20.920.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF003047. TAF1_animal. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47055. SSF47055. 1 hit.
SSF47370. SSF47370. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZX4-1 [UniParc]FASTAAdd to Basket

« Hide

MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ     50
LEGESVLDDE CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI 100
RSTEDAVDYS DINEVAEDES QRHQQTMGSL QPLYHSDYDE DDYDADCEDI 150
DCKLMPPPPP PPGPMKKDKD QDAITCVSES GEDIILPSII APSFLASEKV 200
DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT KLLPSVTELF 250
PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS 300
VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV 350
TDTKPRVAEW RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM 400
MEEFRKLEES NGTDLLADEN FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA 450
SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD KPWYSIFPID NEDLVYGRWE 500
DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT SNSPSKESKK 550
ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR 600
GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP 650
GPHSVQPLLK HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA 700
EYSEENGPLM MQVGMATKIK NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL 750
GSLHPGQLLQ ALENNLFRAP VYLHKMPETD FLIIRTRQGY YIRELVDIFV 800
VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR PRRIRMEDIK 850
KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS 900
PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP 950
WNTTRAFIAA MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP 1000
QAVKKTVTGT DADLRRLSLK NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT 1050
MSTEQAHSGE GPMSKFARGS RFSVAEHQER YKEECQRIFD LQNKVLSSTE 1100
VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW EEQERKELRR 1150
MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR 1200
CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL 1250
RRLKRNQEKE KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL 1300
YYQTNVPPSK PVAMTEEQEE ELEKTVIHND NEELIKVEGT KIVFGKQLIE 1350
NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT VHCDYLNIPH KSIHRRRTDP 1400
MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII TRPMDLQTLR 1450
ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL 1500
KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP 1550
VNKKFVPDYY KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK 1600
YNGPESQYTK TAQEIVNICY QTITEYDEHL TQLEKDICTA KEAALEEAEL 1650
ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD ASVFQDESNL SVLDISTATP 1700
EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG DGDLADEEEG 1750
TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV 1800
GYGGIRPKQP FMLQHASGEH KDGHGK 1826
Length:1,826
Mass (Da):207,302
Last modified:March 1, 2003 - v1
Checksum:i35D780E749AC9B17
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471G → A in a lung small cell carcinoma sample; somatic mutation. 1 Publication
VAR_041934
Natural varianti171 – 1711Q → E.1 Publication
Corresponds to variant rs56352331 [ dbSNP | Ensembl ].
VAR_041935
Natural varianti256 – 2561G → A.1 Publication
Corresponds to variant rs55991718 [ dbSNP | Ensembl ].
VAR_041936
Natural varianti371 – 3711M → V.1 Publication
Corresponds to variant rs17219559 [ dbSNP | Ensembl ].
VAR_041937
Natural varianti532 – 5321I → N.1 Publication
Corresponds to variant rs56128445 [ dbSNP | Ensembl ].
VAR_041938
Natural varianti637 – 6371P → S.1 Publication
Corresponds to variant rs56157814 [ dbSNP | Ensembl ].
VAR_041939
Natural varianti750 – 7501L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041940
Natural varianti762 – 7621L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041941
Natural varianti794 – 7941E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041942
Natural varianti820 – 8201M → T.
Corresponds to variant rs1258 [ dbSNP | Ensembl ].
VAR_048434
Natural varianti845 – 8451R → Q.1 Publication
Corresponds to variant rs34787787 [ dbSNP | Ensembl ].
VAR_041943
Natural varianti1016 – 10161R → C.1 Publication
Corresponds to variant rs35905429 [ dbSNP | Ensembl ].
VAR_041944
Natural varianti1038 – 10381K → N.1 Publication
Corresponds to variant rs55767137 [ dbSNP | Ensembl ].
VAR_041945
Natural varianti1169 – 11691T → I.1 Publication
Corresponds to variant rs55976674 [ dbSNP | Ensembl ].
VAR_041946
Natural varianti1312 – 13121V → L.1 Publication
Corresponds to variant rs55824107 [ dbSNP | Ensembl ].
VAR_041947
Natural varianti1356 – 13561R → C.1 Publication
Corresponds to variant rs56107531 [ dbSNP | Ensembl ].
VAR_041948
Natural varianti1389 – 13891P → S.1 Publication
Corresponds to variant rs56393725 [ dbSNP | Ensembl ].
VAR_041949
Natural varianti1411 – 14111I → V.1 Publication
Corresponds to variant rs34500740 [ dbSNP | Ensembl ].
VAR_041950
Natural varianti1540 – 15401A → T.1 Publication
Corresponds to variant rs55782058 [ dbSNP | Ensembl ].
VAR_041951
Natural varianti1549 – 15491H → Y in a glioblastoma multiforme sample; somatic mutation. 1 Publication
VAR_041952
Natural varianti1731 – 17311K → N.1 Publication
Corresponds to variant rs34241003 [ dbSNP | Ensembl ].
VAR_041953
Natural varianti1805 – 18051I → V.
Corresponds to variant rs16918393 [ dbSNP | Ensembl ].
VAR_048435
Natural varianti1810 – 18101P → L.1 Publication
Corresponds to variant rs56342342 [ dbSNP | Ensembl ].
VAR_041954
Natural varianti1824 – 18241H → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041955

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF390562 mRNA. Translation: AAN40840.1.
CCDSiCCDS35003.1.
RefSeqiNP_722516.1. NM_153809.2.
UniGeneiHs.591086.

Genome annotation databases

EnsembliENST00000242310; ENSP00000418379; ENSG00000122728.
GeneIDi138474.
KEGGihsa:138474.
UCSCiuc003zrg.1. human.

Polymorphism databases

DMDMi57013082.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF390562 mRNA. Translation: AAN40840.1 .
CCDSi CCDS35003.1.
RefSeqi NP_722516.1. NM_153809.2.
UniGenei Hs.591086.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HMH X-ray 2.05 A 1523-1654 [» ]
ProteinModelPortali Q8IZX4.
SMRi Q8IZX4. Positions 1396-1641.
ModBasei Search...

Protein-protein interaction databases

BioGridi 126514. 9 interactions.
IntActi Q8IZX4. 2 interactions.
MINTi MINT-2810023.
STRINGi 9606.ENSP00000418379.

PTM databases

PhosphoSitei Q8IZX4.

Polymorphism databases

DMDMi 57013082.

Proteomic databases

MaxQBi Q8IZX4.
PaxDbi Q8IZX4.
PRIDEi Q8IZX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000242310 ; ENSP00000418379 ; ENSG00000122728 .
GeneIDi 138474.
KEGGi hsa:138474.
UCSCi uc003zrg.1. human.

Organism-specific databases

CTDi 138474.
GeneCardsi GC09M032619.
H-InvDB HIX0169078.
HGNCi HGNC:18056. TAF1L.
HPAi HPA056605.
MIMi 607798. gene.
neXtProti NX_Q8IZX4.
PharmGKBi PA134947802.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5076.
HOGENOMi HOG000020066.
HOVERGENi HBG050223.
InParanoidi Q8IZX4.
KOi K03125.
OMAi VIREEPQ.
OrthoDBi EOG7QNVK2.
PhylomeDBi Q8IZX4.
TreeFami TF313573.

Miscellaneous databases

EvolutionaryTracei Q8IZX4.
GenomeRNAii 138474.
NextBioi 83796.
PROi Q8IZX4.
SOURCEi Search...

Gene expression databases

CleanExi HS_TAF1L.
Genevestigatori Q8IZX4.

Family and domain databases

Gene3Di 1.10.1100.10. 1 hit.
1.20.920.10. 2 hits.
InterProi IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR011177. TAF1_animal.
IPR009067. TAF_II_230-bd.
IPR022591. TFIID_sub1_DUF3591.
[Graphical view ]
Pfami PF00439. Bromodomain. 2 hits.
PF12157. DUF3591. 1 hit.
PF09247. TBP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF003047. TAF1_animal. 1 hit.
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 2 hits.
[Graphical view ]
SUPFAMi SSF47055. SSF47055. 1 hit.
SSF47370. SSF47370. 2 hits.
PROSITEi PS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis."
    Wang P.J., Page D.C.
    Hum. Mol. Genet. 11:2341-2346(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TBP.
    Tissue: Testis.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1523-1654, SUBUNIT.
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-47; GLU-171; ALA-256; VAL-371; ASN-532; SER-637; PHE-750; ILE-762; ASP-794; GLN-845; CYS-1016; ASN-1038; ILE-1169; LEU-1312; CYS-1356; SER-1389; VAL-1411; THR-1540; TYR-1549; ASN-1731; LEU-1810 AND GLN-1824.

Entry informationi

Entry nameiTAF1L_HUMAN
AccessioniPrimary (citable) accession number: Q8IZX4
Secondary accession number(s): Q0VG57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi