##gff-version 3
Q8IZW8	UniProtKB	Signal peptide	1	18	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8IZW8	UniProtKB	Chain	19	715	.	.	.	ID=PRO_0000248213;Note=Tensin-4	
Q8IZW8	UniProtKB	Domain	449	556	.	.	.	Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191	
Q8IZW8	UniProtKB	Domain	582	705	.	.	.	Note=PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q8IZW8	UniProtKB	Region	159	183	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8IZW8	UniProtKB	Region	195	251	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8IZW8	UniProtKB	Region	291	364	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8IZW8	UniProtKB	Region	376	435	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8IZW8	UniProtKB	Compositional bias	161	176	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8IZW8	UniProtKB	Compositional bias	291	346	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8IZW8	UniProtKB	Compositional bias	389	424	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8IZW8	UniProtKB	Site	570	571	.	.	.	Note=Cleavage%3B by caspase-3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15806167;Dbxref=PMID:15806167	
Q8IZW8	UniProtKB	Modified residue	82	82	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976	
Q8IZW8	UniProtKB	Modified residue	248	248	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18691976;Dbxref=PMID:18691976	
Q8IZW8	UniProtKB	Natural variant	179	179	.	.	.	ID=VAR_027264;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12154022;Dbxref=dbSNP:rs3764424,PMID:12154022	
Q8IZW8	UniProtKB	Natural variant	327	327	.	.	.	ID=VAR_055292;Note=T->K;Dbxref=dbSNP:rs33923045	
Q8IZW8	UniProtKB	Natural variant	498	498	.	.	.	ID=VAR_027265;Note=S->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12154022,ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs2290207,PMID:12154022,PMID:14702039	
Q8IZW8	UniProtKB	Natural variant	642	642	.	.	.	ID=VAR_036515;Note=In a colorectal cancer sample%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs148022611,PMID:16959974	
Q8IZW8	UniProtKB	Mutagenesis	100	118	.	.	.	Note=Abolishes focal adhesion localization%3B when associated with A-474. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30321615;Dbxref=PMID:30321615	
Q8IZW8	UniProtKB	Mutagenesis	474	474	.	.	.	Note=Abolishes interaction with DLC1. Abolishes interaction with CBL following EGF stimulation. Loss of ability to reduce ubiquitination of activated EGFR. Significant decrease in interaction with MET%2C faster MET trafficking to the lysosome and significant increase in MET turnover. Significant inhibition of basal and HGF-stimulated cell migration. No effect on focal adhesion localization. Abolishes focal adhesion localization%3B when associated with 100-F--L-118 DEL. R->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17190795,ECO:0000269|PubMed:23774213,ECO:0000269|PubMed:24814316,ECO:0000269|PubMed:30321615;Dbxref=PMID:17190795,PMID:23774213,PMID:24814316,PMID:30321615	
Q8IZW8	UniProtKB	Mutagenesis	506	506	.	.	.	Note=No effect on cleavage by caspase-3. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15806167;Dbxref=PMID:15806167	
Q8IZW8	UniProtKB	Mutagenesis	570	570	.	.	.	Note=Abolishes cleavage by caspase-3. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15806167;Dbxref=PMID:15806167	
Q8IZW8	UniProtKB	Mutagenesis	650	650	.	.	.	Note=Abolishes interaction with ITGB1. Does not affect interaction with CBL following EGF stimulation. R->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17643115,ECO:0000269|PubMed:23774213;Dbxref=PMID:17643115,PMID:23774213	
Q8IZW8	UniProtKB	Sequence conflict	163	163	.	.	.	Note=G->W;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IZW8	UniProtKB	Sequence conflict	360	360	.	.	.	Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q8IZW8	UniProtKB	Sequence conflict	623	623	.	.	.	Note=K->E;Ontology_term=ECO:0000305;evidence=ECO:0000305