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Q8IZW8

- TENS4_HUMAN

UniProt

Q8IZW8 - TENS4_HUMAN

Protein

Tensin-4

Gene

TNS4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton By similarity. May promote apoptosis, via its cleavage by caspase-3.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei570 – 5712Cleavage; by caspase-3

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. protein localization Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    SignaLinkiQ8IZW8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tensin-4
    Alternative name(s):
    C-terminal tensin-like protein
    Gene namesi
    Name:TNS4
    Synonyms:CTEN
    ORF Names:PP14434
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:24352. TNS4.

    Subcellular locationi

    Cell junctionfocal adhesion 1 Publication. Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. focal adhesion Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi506 – 5061D → A: No effect on cleavage by caspase-3. 1 Publication
    Mutagenesisi570 – 5701D → A: Abolishes cleavage by caspase-3. 1 Publication

    Organism-specific databases

    PharmGKBiPA142670717.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 715697Tensin-4PRO_0000248213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei82 – 821Phosphoserine1 Publication
    Modified residuei248 – 2481Phosphoserine1 Publication

    Post-translational modificationi

    Proteolytically cleaved by caspase-3 during apoptosis.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IZW8.
    PaxDbiQ8IZW8.
    PRIDEiQ8IZW8.

    PTM databases

    PhosphoSiteiQ8IZW8.

    Miscellaneous databases

    PMAP-CutDBQ8IZW8.

    Expressioni

    Tissue specificityi

    Prostate and placenta. Down regulated in prostate cancer.1 Publication

    Gene expression databases

    BgeeiQ8IZW8.
    CleanExiHS_TNS4.
    GenevestigatoriQ8IZW8.

    Organism-specific databases

    HPAiHPA021913.

    Interactioni

    Subunit structurei

    Binds to actin filaments and interacts with phosphotyrosine-containing proteins.By similarity

    Protein-protein interaction databases

    BioGridi124383. 5 interactions.
    IntActiQ8IZW8. 6 interactions.
    MINTiMINT-1493010.
    STRINGi9606.ENSP00000254051.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZW8.
    SMRiQ8IZW8. Positions 443-557, 580-709.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini449 – 556108SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini548 – 714167Phosphatase tensin-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi168 – 324157Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, Signal

    Phylogenomic databases

    eggNOGiNOG254290.
    HOGENOMiHOG000230981.
    HOVERGENiHBG080039.
    InParanoidiQ8IZW8.
    KOiK18080.
    OMAiLNQMILE.
    OrthoDBiEOG7QG43J.
    PhylomeDBiQ8IZW8.
    TreeFamiTF315996.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR013625. PTB.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF08416. PTB. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8IZW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQVMSSPLL AGGHAVSLAP CDEPRRTLHP APSPSLPPQC SYYTTEGWGA    50
    QALMAPVPCM GPPGRLQQAP QVEAKATCFL PSPGEKALGT PEDLDSYIDF 100
    SLESLNQMIL ELDPTFQLLP PGTGGSQAEL AQSTMSMRKK EESEALDIKY 150
    IEVTSARSRC HDGPQHCSSP SVTPPFGSLR SGGLLLSRDV PRETRSSSES 200
    LIFSGNQGRG HQRPLPPSEG LSPRPPNSPS ISIPCMGSKA SSPHGLGSPL 250
    VASPRLEKRL GGLAPQRGSR ISVLSASPVS DVSYMFGSSQ SLLHSSNSSH 300
    QSSSRSLESP ANSSSSLHSL GSVSLCTRPS DFQAPRNPTL TMGQPRTPHS 350
    PPLAKEHASS CPPSITNSMV DIPIVLINGC PEPGSSPPQR TPGHQNSVQP 400
    GAASPSNPCP ATRSNSQTLS DAPFTTCPEG PARDMQPTMK FVMDTSKYWF 450
    KPNITREQAI ELLRKEEPGA FVIRDSSSYR GSFGLALKVQ EVPASAQSRP 500
    GEDSNDLIRH FLIESSAKGV HLKGADEEPY FGSLSAFVCQ HSIMALALPC 550
    KLTIPQRELG GADGASDSTD SPASCQKKSA GCHTLYLSSV SVETLTGALA 600
    VQKAISTTFE RDILPTPTVV HFKVTEQGIT LTDVQRKVFF RRHYPLTTLR 650
    FCGMDPEQRK WQKYCKPSWI FGFVAKSQTE PQENVCHLFA EYDMVQPASQ 700
    VIGLVTALLQ DAERM 715
    Length:715
    Mass (Da):76,764
    Last modified:May 5, 2009 - v3
    Checksum:iE6AD7CB6B6DDA5D2
    GO

    Sequence cautioni

    The sequence AAQ15257.1 differs from that shown. Reason: Frameshift at positions 85, 296, 472 and 602.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631G → W in AAN32666. (PubMed:12154022)Curated
    Sequence conflicti360 – 3601S → I in AAN32666. (PubMed:12154022)Curated
    Sequence conflicti360 – 3601S → I in BAB55413. (PubMed:14702039)Curated
    Sequence conflicti623 – 6231K → E in AAN32666. (PubMed:12154022)Curated
    Sequence conflicti623 – 6231K → E in BAB55413. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti179 – 1791L → P.1 Publication
    Corresponds to variant rs3764424 [ dbSNP | Ensembl ].
    VAR_027264
    Natural varianti327 – 3271T → K.
    Corresponds to variant rs33923045 [ dbSNP | Ensembl ].
    VAR_055292
    Natural varianti498 – 4981S → N.2 Publications
    Corresponds to variant rs2290207 [ dbSNP | Ensembl ].
    VAR_027265
    Natural varianti642 – 6421R → C in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036515

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF417488 mRNA. Translation: AAN32666.1.
    AF370421 mRNA. Translation: AAQ15257.1. Frameshift.
    AK027856 mRNA. Translation: BAB55413.1.
    AC018629 Genomic DNA. No translation available.
    BC018706 mRNA. Translation: AAH18706.1.
    CCDSiCCDS11368.1.
    RefSeqiNP_116254.4. NM_032865.5.
    UniGeneiHs.438292.

    Genome annotation databases

    EnsembliENST00000254051; ENSP00000254051; ENSG00000131746.
    GeneIDi84951.
    KEGGihsa:84951.
    UCSCiuc010cxb.3. human.

    Polymorphism databases

    DMDMi229463025.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF417488 mRNA. Translation: AAN32666.1 .
    AF370421 mRNA. Translation: AAQ15257.1 . Frameshift.
    AK027856 mRNA. Translation: BAB55413.1 .
    AC018629 Genomic DNA. No translation available.
    BC018706 mRNA. Translation: AAH18706.1 .
    CCDSi CCDS11368.1.
    RefSeqi NP_116254.4. NM_032865.5.
    UniGenei Hs.438292.

    3D structure databases

    ProteinModelPortali Q8IZW8.
    SMRi Q8IZW8. Positions 443-557, 580-709.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124383. 5 interactions.
    IntActi Q8IZW8. 6 interactions.
    MINTi MINT-1493010.
    STRINGi 9606.ENSP00000254051.

    PTM databases

    PhosphoSitei Q8IZW8.

    Polymorphism databases

    DMDMi 229463025.

    Proteomic databases

    MaxQBi Q8IZW8.
    PaxDbi Q8IZW8.
    PRIDEi Q8IZW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254051 ; ENSP00000254051 ; ENSG00000131746 .
    GeneIDi 84951.
    KEGGi hsa:84951.
    UCSCi uc010cxb.3. human.

    Organism-specific databases

    CTDi 84951.
    GeneCardsi GC17M038632.
    H-InvDB HIX0013799.
    HGNCi HGNC:24352. TNS4.
    HPAi HPA021913.
    MIMi 608385. gene.
    neXtProti NX_Q8IZW8.
    PharmGKBi PA142670717.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254290.
    HOGENOMi HOG000230981.
    HOVERGENi HBG080039.
    InParanoidi Q8IZW8.
    KOi K18080.
    OMAi LNQMILE.
    OrthoDBi EOG7QG43J.
    PhylomeDBi Q8IZW8.
    TreeFami TF315996.

    Enzyme and pathway databases

    SignaLinki Q8IZW8.

    Miscellaneous databases

    ChiTaRSi TNS4. human.
    GeneWikii TNS4.
    GenomeRNAii 84951.
    NextBioi 75438.
    PMAP-CutDB Q8IZW8.
    PROi Q8IZW8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IZW8.
    CleanExi HS_TNS4.
    Genevestigatori Q8IZW8.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR013625. PTB.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF08416. PTB. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer."
      Lo S.H., Lo T.B.
      Cancer Res. 62:4217-4221(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS PRO-179 AND ASN-498.
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-498.
      Tissue: Placenta.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Cleavage of cten by caspase-3 during apoptosis."
      Lo S.-S., Lo S.H., Lo S.H.
      Oncogene 24:4311-4314(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE BY CASPASE-3, MUTAGENESIS OF ASP-506 AND ASP-570.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82 AND SER-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-642.

    Entry informationi

    Entry nameiTENS4_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZW8
    Secondary accession number(s): A6NMJ7
    , Q71RB7, Q8WV64, Q96JV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3