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Q8IZW8 (TENS4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tensin-4
Alternative name(s):
C-terminal tensin-like protein
Gene names
Name:TNS4
Synonyms:CTEN
ORF Names:PP14434
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length715 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton By similarity. May promote apoptosis, via its cleavage by caspase-3.

Subunit structure

Binds to actin filaments and interacts with phosphotyrosine-containing proteins By similarity.

Subcellular location

Cell junctionfocal adhesion. Cytoplasmcytoskeleton Ref.1.

Tissue specificity

Prostate and placenta. Down regulated in prostate cancer. Ref.1

Post-translational modification

Proteolytically cleaved by caspase-3 during apoptosis. Ref.6

Sequence similarities

Contains 1 phosphatase tensin-type domain.

Contains 1 SH2 domain.

Sequence caution

The sequence AAQ15257.1 differs from that shown. Reason: Frameshift at positions 85, 296, 472 and 602.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentCell junction
Cytoplasm
Cytoskeleton
   Coding sequence diversityPolymorphism
   DomainSH2 domain
Signal
   LigandActin-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

protein localization

Inferred from direct assay PubMed 17190795. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

focal adhesion

Inferred from direct assay PubMed 17190795. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 715697Tensin-4
PRO_0000248213

Regions

Domain449 – 556108SH2
Domain548 – 714167Phosphatase tensin-type
Compositional bias168 – 324157Ser-rich

Sites

Site570 – 5712Cleavage; by caspase-3

Amino acid modifications

Modified residue821Phosphoserine Ref.7
Modified residue2481Phosphoserine Ref.7

Natural variations

Natural variant1791L → P. Ref.1
Corresponds to variant rs3764424 [ dbSNP | Ensembl ].
VAR_027264
Natural variant3271T → K.
Corresponds to variant rs33923045 [ dbSNP | Ensembl ].
VAR_055292
Natural variant4981S → N. Ref.1 Ref.3
Corresponds to variant rs2290207 [ dbSNP | Ensembl ].
VAR_027265
Natural variant6421R → C in a colorectal cancer sample; somatic mutation. Ref.9
VAR_036515

Experimental info

Mutagenesis5061D → A: No effect on cleavage by caspase-3. Ref.6
Mutagenesis5701D → A: Abolishes cleavage by caspase-3. Ref.6
Sequence conflict1631G → W in AAN32666. Ref.1
Sequence conflict3601S → I in AAN32666. Ref.1
Sequence conflict3601S → I in BAB55413. Ref.3
Sequence conflict6231K → E in AAN32666. Ref.1
Sequence conflict6231K → E in BAB55413. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8IZW8 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: E6AD7CB6B6DDA5D2

FASTA71576,764
        10         20         30         40         50         60 
MSQVMSSPLL AGGHAVSLAP CDEPRRTLHP APSPSLPPQC SYYTTEGWGA QALMAPVPCM 

        70         80         90        100        110        120 
GPPGRLQQAP QVEAKATCFL PSPGEKALGT PEDLDSYIDF SLESLNQMIL ELDPTFQLLP 

       130        140        150        160        170        180 
PGTGGSQAEL AQSTMSMRKK EESEALDIKY IEVTSARSRC HDGPQHCSSP SVTPPFGSLR 

       190        200        210        220        230        240 
SGGLLLSRDV PRETRSSSES LIFSGNQGRG HQRPLPPSEG LSPRPPNSPS ISIPCMGSKA 

       250        260        270        280        290        300 
SSPHGLGSPL VASPRLEKRL GGLAPQRGSR ISVLSASPVS DVSYMFGSSQ SLLHSSNSSH 

       310        320        330        340        350        360 
QSSSRSLESP ANSSSSLHSL GSVSLCTRPS DFQAPRNPTL TMGQPRTPHS PPLAKEHASS 

       370        380        390        400        410        420 
CPPSITNSMV DIPIVLINGC PEPGSSPPQR TPGHQNSVQP GAASPSNPCP ATRSNSQTLS 

       430        440        450        460        470        480 
DAPFTTCPEG PARDMQPTMK FVMDTSKYWF KPNITREQAI ELLRKEEPGA FVIRDSSSYR 

       490        500        510        520        530        540 
GSFGLALKVQ EVPASAQSRP GEDSNDLIRH FLIESSAKGV HLKGADEEPY FGSLSAFVCQ 

       550        560        570        580        590        600 
HSIMALALPC KLTIPQRELG GADGASDSTD SPASCQKKSA GCHTLYLSSV SVETLTGALA 

       610        620        630        640        650        660 
VQKAISTTFE RDILPTPTVV HFKVTEQGIT LTDVQRKVFF RRHYPLTTLR FCGMDPEQRK 

       670        680        690        700        710 
WQKYCKPSWI FGFVAKSQTE PQENVCHLFA EYDMVQPASQ VIGLVTALLQ DAERM 

« Hide

References

« Hide 'large scale' references
[1]"Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer."
Lo S.H., Lo T.B.
Cancer Res. 62:4217-4221(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS PRO-179 AND ASN-498.
[2]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-498.
Tissue: Placenta.
[4]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Cleavage of cten by caspase-3 during apoptosis."
Lo S.-S., Lo S.H., Lo S.H.
Oncogene 24:4311-4314(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE BY CASPASE-3, MUTAGENESIS OF ASP-506 AND ASP-570.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82 AND SER-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-642.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF417488 mRNA. Translation: AAN32666.1.
AF370421 mRNA. Translation: AAQ15257.1. Frameshift.
AK027856 mRNA. Translation: BAB55413.1.
AC018629 Genomic DNA. No translation available.
BC018706 mRNA. Translation: AAH18706.1.
RefSeqNP_116254.4. NM_032865.5.
UniGeneHs.438292.

3D structure databases

ProteinModelPortalQ8IZW8.
SMRQ8IZW8. Positions 443-578, 580-709.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124383. 5 interactions.
IntActQ8IZW8. 3 interactions.
MINTMINT-1493010.
STRING9606.ENSP00000254051.

PTM databases

PhosphoSiteQ8IZW8.

Polymorphism databases

DMDM229463025.

Proteomic databases

PaxDbQ8IZW8.
PRIDEQ8IZW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254051; ENSP00000254051; ENSG00000131746.
GeneID84951.
KEGGhsa:84951.
UCSCuc010cxb.3. human.

Organism-specific databases

CTD84951.
GeneCardsGC17M038632.
H-InvDBHIX0013799.
HGNCHGNC:24352. TNS4.
HPAHPA021913.
MIM608385. gene.
neXtProtNX_Q8IZW8.
PharmGKBPA142670717.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG254290.
HOGENOMHOG000230981.
HOVERGENHBG080039.
InParanoidQ8IZW8.
OMALNQMILE.
OrthoDBEOG7QG43J.
PhylomeDBQ8IZW8.
TreeFamTF315996.

Enzyme and pathway databases

SignaLinkQ8IZW8.

Gene expression databases

BgeeQ8IZW8.
CleanExHS_TNS4.
GenevestigatorQ8IZW8.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011993. PH_like_dom.
IPR013625. PTB.
IPR000980. SH2.
[Graphical view]
PfamPF08416. PTB. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTNS4. human.
GeneWikiTNS4.
GenomeRNAi84951.
NextBio75438.
PMAP-CutDBQ8IZW8.
PROQ8IZW8.
SOURCESearch...

Entry information

Entry nameTENS4_HUMAN
AccessionPrimary (citable) accession number: Q8IZW8
Secondary accession number(s): A6NMJ7 expand/collapse secondary AC list , Q71RB7, Q8WV64, Q96JV4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM