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Protein

Tensin-4

Gene

TNS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • protein localization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-8875513. MET interacts with TNS proteins.
SignaLinkiQ8IZW8.

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-4
Alternative name(s):
C-terminal tensin-like protein
Gene namesi
Name:TNS4
Synonyms:CTEN
ORF Names:PP14434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24352. TNS4.

Subcellular locationi

  • Cell junctionfocal adhesion 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • focal adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi506D → A: No effect on cleavage by caspase-3. 1 Publication1
Mutagenesisi570D → A: Abolishes cleavage by caspase-3. 1 Publication1

Organism-specific databases

DisGeNETi84951.
OpenTargetsiENSG00000131746.
PharmGKBiPA142670717.

Polymorphism and mutation databases

BioMutaiTNS4.
DMDMi229463025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000024821319 – 715Tensin-4Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei570 – 571Cleavage; by caspase-32

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IZW8.
MaxQBiQ8IZW8.
PaxDbiQ8IZW8.
PeptideAtlasiQ8IZW8.
PRIDEiQ8IZW8.

PTM databases

iPTMnetiQ8IZW8.
PhosphoSitePlusiQ8IZW8.

Miscellaneous databases

PMAP-CutDBQ8IZW8.

Expressioni

Tissue specificityi

Prostate and placenta. Down regulated in prostate cancer.1 Publication

Gene expression databases

BgeeiENSG00000131746.
CleanExiHS_TNS4.
ExpressionAtlasiQ8IZW8. baseline and differential.
GenevisibleiQ8IZW8. HS.

Organism-specific databases

HPAiHPA021913.
HPA061761.

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins.By similarity

Protein-protein interaction databases

BioGridi124383. 11 interactors.
IntActiQ8IZW8. 17 interactors.
MINTiMINT-1493010.
STRINGi9606.ENSP00000254051.

Structurei

3D structure databases

ProteinModelPortaliQ8IZW8.
SMRiQ8IZW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini449 – 556SH2PROSITE-ProRule annotationAdd BLAST108
Domaini548 – 714Phosphatase tensin-typeAdd BLAST167

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 324Ser-richAdd BLAST157

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, Signal

Phylogenomic databases

eggNOGiENOG410IUIK. Eukaryota.
ENOG41125SH. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000230981.
HOVERGENiHBG080039.
InParanoidiQ8IZW8.
KOiK18080.
OMAiLNQMILE.
OrthoDBiEOG091G0G8Y.
PhylomeDBiQ8IZW8.
TreeFamiTF315996.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR033929. Tensin_PTB.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQVMSSPLL AGGHAVSLAP CDEPRRTLHP APSPSLPPQC SYYTTEGWGA
60 70 80 90 100
QALMAPVPCM GPPGRLQQAP QVEAKATCFL PSPGEKALGT PEDLDSYIDF
110 120 130 140 150
SLESLNQMIL ELDPTFQLLP PGTGGSQAEL AQSTMSMRKK EESEALDIKY
160 170 180 190 200
IEVTSARSRC HDGPQHCSSP SVTPPFGSLR SGGLLLSRDV PRETRSSSES
210 220 230 240 250
LIFSGNQGRG HQRPLPPSEG LSPRPPNSPS ISIPCMGSKA SSPHGLGSPL
260 270 280 290 300
VASPRLEKRL GGLAPQRGSR ISVLSASPVS DVSYMFGSSQ SLLHSSNSSH
310 320 330 340 350
QSSSRSLESP ANSSSSLHSL GSVSLCTRPS DFQAPRNPTL TMGQPRTPHS
360 370 380 390 400
PPLAKEHASS CPPSITNSMV DIPIVLINGC PEPGSSPPQR TPGHQNSVQP
410 420 430 440 450
GAASPSNPCP ATRSNSQTLS DAPFTTCPEG PARDMQPTMK FVMDTSKYWF
460 470 480 490 500
KPNITREQAI ELLRKEEPGA FVIRDSSSYR GSFGLALKVQ EVPASAQSRP
510 520 530 540 550
GEDSNDLIRH FLIESSAKGV HLKGADEEPY FGSLSAFVCQ HSIMALALPC
560 570 580 590 600
KLTIPQRELG GADGASDSTD SPASCQKKSA GCHTLYLSSV SVETLTGALA
610 620 630 640 650
VQKAISTTFE RDILPTPTVV HFKVTEQGIT LTDVQRKVFF RRHYPLTTLR
660 670 680 690 700
FCGMDPEQRK WQKYCKPSWI FGFVAKSQTE PQENVCHLFA EYDMVQPASQ
710
VIGLVTALLQ DAERM
Length:715
Mass (Da):76,764
Last modified:May 5, 2009 - v3
Checksum:iE6AD7CB6B6DDA5D2
GO

Sequence cautioni

The sequence AAQ15257 differs from that shown. Reason: Frameshift at positions 85, 296, 472 and 602.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163G → W in AAN32666 (PubMed:12154022).Curated1
Sequence conflicti360S → I in AAN32666 (PubMed:12154022).Curated1
Sequence conflicti360S → I in BAB55413 (PubMed:14702039).Curated1
Sequence conflicti623K → E in AAN32666 (PubMed:12154022).Curated1
Sequence conflicti623K → E in BAB55413 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027264179L → P.1 PublicationCorresponds to variant rs3764424dbSNPEnsembl.1
Natural variantiVAR_055292327T → K.Corresponds to variant rs33923045dbSNPEnsembl.1
Natural variantiVAR_027265498S → N.2 PublicationsCorresponds to variant rs2290207dbSNPEnsembl.1
Natural variantiVAR_036515642R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs148022611dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF417488 mRNA. Translation: AAN32666.1.
AF370421 mRNA. Translation: AAQ15257.1. Frameshift.
AK027856 mRNA. Translation: BAB55413.1.
AC018629 Genomic DNA. No translation available.
BC018706 mRNA. Translation: AAH18706.1.
CCDSiCCDS11368.1.
RefSeqiNP_116254.4. NM_032865.5.
UniGeneiHs.438292.

Genome annotation databases

EnsembliENST00000254051; ENSP00000254051; ENSG00000131746.
GeneIDi84951.
KEGGihsa:84951.
UCSCiuc010cxb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF417488 mRNA. Translation: AAN32666.1.
AF370421 mRNA. Translation: AAQ15257.1. Frameshift.
AK027856 mRNA. Translation: BAB55413.1.
AC018629 Genomic DNA. No translation available.
BC018706 mRNA. Translation: AAH18706.1.
CCDSiCCDS11368.1.
RefSeqiNP_116254.4. NM_032865.5.
UniGeneiHs.438292.

3D structure databases

ProteinModelPortaliQ8IZW8.
SMRiQ8IZW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124383. 11 interactors.
IntActiQ8IZW8. 17 interactors.
MINTiMINT-1493010.
STRINGi9606.ENSP00000254051.

PTM databases

iPTMnetiQ8IZW8.
PhosphoSitePlusiQ8IZW8.

Polymorphism and mutation databases

BioMutaiTNS4.
DMDMi229463025.

Proteomic databases

EPDiQ8IZW8.
MaxQBiQ8IZW8.
PaxDbiQ8IZW8.
PeptideAtlasiQ8IZW8.
PRIDEiQ8IZW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254051; ENSP00000254051; ENSG00000131746.
GeneIDi84951.
KEGGihsa:84951.
UCSCiuc010cxb.4. human.

Organism-specific databases

CTDi84951.
DisGeNETi84951.
GeneCardsiTNS4.
H-InvDBHIX0013799.
HGNCiHGNC:24352. TNS4.
HPAiHPA021913.
HPA061761.
MIMi608385. gene.
neXtProtiNX_Q8IZW8.
OpenTargetsiENSG00000131746.
PharmGKBiPA142670717.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUIK. Eukaryota.
ENOG41125SH. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000230981.
HOVERGENiHBG080039.
InParanoidiQ8IZW8.
KOiK18080.
OMAiLNQMILE.
OrthoDBiEOG091G0G8Y.
PhylomeDBiQ8IZW8.
TreeFamiTF315996.

Enzyme and pathway databases

ReactomeiR-HSA-8875513. MET interacts with TNS proteins.
SignaLinkiQ8IZW8.

Miscellaneous databases

ChiTaRSiTNS4. human.
GeneWikiiTNS4.
GenomeRNAii84951.
PMAP-CutDBQ8IZW8.
PROiQ8IZW8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131746.
CleanExiHS_TNS4.
ExpressionAtlasiQ8IZW8. baseline and differential.
GenevisibleiQ8IZW8. HS.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR033929. Tensin_PTB.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTENS4_HUMAN
AccessioniPrimary (citable) accession number: Q8IZW8
Secondary accession number(s): A6NMJ7
, Q71RB7, Q8WV64, Q96JV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.