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Protein

Retinol dehydrogenase 10

Gene

RDH10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.1 Publication

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.1 Publication

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197SubstrateBy similarity1
Active sitei210Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 64NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • NADP-retinol dehydrogenase activity Source: Reactome
  • retinol dehydrogenase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000121039-MONOMER.
ZFISH:ENSG00000121039-MONOMER.
BRENDAi1.1.1.105. 2681.
1.1.1.315. 2681.
1.1.1.87. 2681.
ReactomeiR-HSA-2453902. The canonical retinoid cycle in rods (twilight vision).
R-HSA-5365859. RA biosynthesis pathway.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 10 (EC:1.1.1.300)
Alternative name(s):
Short chain dehydrogenase/reductase family 16C member 4
Gene namesi
Name:RDH10
Synonyms:SDR16C4
ORF Names:UNQ9375/PRO34191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:19975. RDH10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Signal-anchorSequence analysisAdd BLAST21

GO - Cellular componenti

  • cell body Source: Ensembl
  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum membrane Source: Reactome
  • integral component of membrane Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • organelle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi157506.
OpenTargetsiENSG00000121039.
PharmGKBiPA134989620.

Polymorphism and mutation databases

BioMutaiRDH10.
DMDMi74750799.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076821 – 341Retinol dehydrogenase 10Add BLAST341

Proteomic databases

EPDiQ8IZV5.
MaxQBiQ8IZV5.
PaxDbiQ8IZV5.
PeptideAtlasiQ8IZV5.
PRIDEiQ8IZV5.

PTM databases

iPTMnetiQ8IZV5.
PhosphoSitePlusiQ8IZV5.

Expressioni

Tissue specificityi

Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000121039.
CleanExiHS_RDH10.
ExpressionAtlasiQ8IZV5. baseline and differential.
GenevisibleiQ8IZV5. HS.

Organism-specific databases

HPAiHPA049199.

Interactioni

Protein-protein interaction databases

BioGridi127600. 2 interactors.
STRINGi9606.ENSP00000240285.

Structurei

3D structure databases

ProteinModelPortaliQ8IZV5.
SMRiQ8IZV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ8IZV5.
KOiK11151.
OMAiQRKEAMN.
OrthoDBiEOG091G0825.
PhylomeDBiQ8IZV5.
TreeFamiTF312837.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR032970. RDH10.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PTHR24322:SF466. PTHR24322:SF466. 3 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR
60 70 80 90 100
LFALEFARRR ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG
110 120 130 140 150
EEEILPHCNL QVFTYTCDVG KRENVYLTAE RVRKEVGEVS VLVNNAGVVS
160 170 180 190 200
GHHLLECPDE LIERTMMVNC HAHFWTTKAF LPTMLEINHG HIVTVASSLG
210 220 230 240 250
LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL VCPYLVDTGM
260 270 280 290 300
FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK
310 320 330 340
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I
Length:341
Mass (Da):38,087
Last modified:March 1, 2003 - v1
Checksum:iD10ABE05E7D11FC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456765 mRNA. Translation: AAN64747.1.
AY358270 mRNA. Translation: AAQ88637.1.
BC067131 mRNA. Translation: AAH67131.1.
CCDSiCCDS6213.1.
RefSeqiNP_742034.1. NM_172037.4.
UniGeneiHs.244940.

Genome annotation databases

EnsembliENST00000240285; ENSP00000240285; ENSG00000121039.
GeneIDi157506.
KEGGihsa:157506.
UCSCiuc003xzi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456765 mRNA. Translation: AAN64747.1.
AY358270 mRNA. Translation: AAQ88637.1.
BC067131 mRNA. Translation: AAH67131.1.
CCDSiCCDS6213.1.
RefSeqiNP_742034.1. NM_172037.4.
UniGeneiHs.244940.

3D structure databases

ProteinModelPortaliQ8IZV5.
SMRiQ8IZV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127600. 2 interactors.
STRINGi9606.ENSP00000240285.

PTM databases

iPTMnetiQ8IZV5.
PhosphoSitePlusiQ8IZV5.

Polymorphism and mutation databases

BioMutaiRDH10.
DMDMi74750799.

Proteomic databases

EPDiQ8IZV5.
MaxQBiQ8IZV5.
PaxDbiQ8IZV5.
PeptideAtlasiQ8IZV5.
PRIDEiQ8IZV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240285; ENSP00000240285; ENSG00000121039.
GeneIDi157506.
KEGGihsa:157506.
UCSCiuc003xzi.4. human.

Organism-specific databases

CTDi157506.
DisGeNETi157506.
GeneCardsiRDH10.
HGNCiHGNC:19975. RDH10.
HPAiHPA049199.
MIMi607599. gene.
neXtProtiNX_Q8IZV5.
OpenTargetsiENSG00000121039.
PharmGKBiPA134989620.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ8IZV5.
KOiK11151.
OMAiQRKEAMN.
OrthoDBiEOG091G0825.
PhylomeDBiQ8IZV5.
TreeFamiTF312837.

Enzyme and pathway databases

UniPathwayiUPA00912.
BioCyciMetaCyc:ENSG00000121039-MONOMER.
ZFISH:ENSG00000121039-MONOMER.
BRENDAi1.1.1.105. 2681.
1.1.1.315. 2681.
1.1.1.87. 2681.
ReactomeiR-HSA-2453902. The canonical retinoid cycle in rods (twilight vision).
R-HSA-5365859. RA biosynthesis pathway.

Miscellaneous databases

GenomeRNAii157506.
PROiQ8IZV5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121039.
CleanExiHS_RDH10.
ExpressionAtlasiQ8IZV5. baseline and differential.
GenevisibleiQ8IZV5. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR032970. RDH10.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PTHR24322:SF466. PTHR24322:SF466. 3 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRDH10_HUMAN
AccessioniPrimary (citable) accession number: Q8IZV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.