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Protein

Retinol dehydrogenase 10

Gene

RDH10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.1 Publication

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei197 – 1971SubstrateBy similarity
Active sitei210 – 2101Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 6425NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. NADP-retinol dehydrogenase activity Source: UniProtKB-EC
  2. retinol dehydrogenase activity Source: UniProtKB

GO - Biological processi

  1. bud elongation involved in lung branching Source: Ensembl
  2. ear development Source: Ensembl
  3. embryonic camera-type eye development Source: Ensembl
  4. embryonic forelimb morphogenesis Source: Ensembl
  5. embryonic viscerocranium morphogenesis Source: Ensembl
  6. gonad development Source: Ensembl
  7. in utero embryonic development Source: Ensembl
  8. metanephros development Source: Ensembl
  9. neural crest cell development Source: Ensembl
  10. nose development Source: Ensembl
  11. phototransduction, visible light Source: Reactome
  12. primary lung bud formation Source: Ensembl
  13. retinal metabolic process Source: UniProtKB
  14. retinoic acid biosynthetic process Source: Ensembl
  15. retinoid metabolic process Source: Reactome
  16. retinol metabolic process Source: UniProtKB
  17. visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000121039-MONOMER.
BRENDAi1.1.1.105. 2681.
1.1.1.315. 2681.
1.1.1.87. 2681.
ReactomeiREACT_160156. The canonical retinoid cycle in rods (twilight vision).
REACT_268561. RA biosynthesis pathway.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 10 (EC:1.1.1.300)
Alternative name(s):
Short chain dehydrogenase/reductase family 16C member 4
Gene namesi
Name:RDH10
Synonyms:SDR16C4
ORF Names:UNQ9375/PRO34191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:19975. RDH10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Signal-anchorSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. endoplasmic reticulum membrane Source: Reactome
  4. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989620.

Polymorphism and mutation databases

BioMutaiRDH10.
DMDMi74750799.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Retinol dehydrogenase 10PRO_0000307682Add
BLAST

Proteomic databases

MaxQBiQ8IZV5.
PaxDbiQ8IZV5.
PRIDEiQ8IZV5.

PTM databases

PhosphoSiteiQ8IZV5.

Expressioni

Tissue specificityi

Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle.2 Publications

Gene expression databases

BgeeiQ8IZV5.
CleanExiHS_RDH10.
ExpressionAtlasiQ8IZV5. baseline and differential.
GenevestigatoriQ8IZV5.

Interactioni

Protein-protein interaction databases

BioGridi127600. 2 interactions.
STRINGi9606.ENSP00000240285.

Structurei

3D structure databases

ProteinModelPortaliQ8IZV5.
SMRiQ8IZV5. Positions 30-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ8IZV5.
KOiK11151.
OMAiMNNNEAK.
OrthoDBiEOG7Z3F50.
PhylomeDBiQ8IZV5.
TreeFamiTF312837.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR
60 70 80 90 100
LFALEFARRR ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG
110 120 130 140 150
EEEILPHCNL QVFTYTCDVG KRENVYLTAE RVRKEVGEVS VLVNNAGVVS
160 170 180 190 200
GHHLLECPDE LIERTMMVNC HAHFWTTKAF LPTMLEINHG HIVTVASSLG
210 220 230 240 250
LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL VCPYLVDTGM
260 270 280 290 300
FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK
310 320 330 340
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I
Length:341
Mass (Da):38,087
Last modified:March 1, 2003 - v1
Checksum:iD10ABE05E7D11FC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456765 mRNA. Translation: AAN64747.1.
AY358270 mRNA. Translation: AAQ88637.1.
BC067131 mRNA. Translation: AAH67131.1.
CCDSiCCDS6213.1.
RefSeqiNP_742034.1. NM_172037.4.
UniGeneiHs.244940.

Genome annotation databases

EnsembliENST00000240285; ENSP00000240285; ENSG00000121039.
GeneIDi157506.
KEGGihsa:157506.
UCSCiuc003xzi.3. human.

Polymorphism and mutation databases

BioMutaiRDH10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456765 mRNA. Translation: AAN64747.1.
AY358270 mRNA. Translation: AAQ88637.1.
BC067131 mRNA. Translation: AAH67131.1.
CCDSiCCDS6213.1.
RefSeqiNP_742034.1. NM_172037.4.
UniGeneiHs.244940.

3D structure databases

ProteinModelPortaliQ8IZV5.
SMRiQ8IZV5. Positions 30-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127600. 2 interactions.
STRINGi9606.ENSP00000240285.

PTM databases

PhosphoSiteiQ8IZV5.

Polymorphism and mutation databases

BioMutaiRDH10.
DMDMi74750799.

Proteomic databases

MaxQBiQ8IZV5.
PaxDbiQ8IZV5.
PRIDEiQ8IZV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240285; ENSP00000240285; ENSG00000121039.
GeneIDi157506.
KEGGihsa:157506.
UCSCiuc003xzi.3. human.

Organism-specific databases

CTDi157506.
GeneCardsiGC08P074207.
HGNCiHGNC:19975. RDH10.
MIMi607599. gene.
neXtProtiNX_Q8IZV5.
PharmGKBiPA134989620.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ8IZV5.
KOiK11151.
OMAiMNNNEAK.
OrthoDBiEOG7Z3F50.
PhylomeDBiQ8IZV5.
TreeFamiTF312837.

Enzyme and pathway databases

UniPathwayiUPA00912.
BioCyciMetaCyc:ENSG00000121039-MONOMER.
BRENDAi1.1.1.105. 2681.
1.1.1.315. 2681.
1.1.1.87. 2681.
ReactomeiREACT_160156. The canonical retinoid cycle in rods (twilight vision).
REACT_268561. RA biosynthesis pathway.

Miscellaneous databases

GenomeRNAii157506.
NextBioi87473.
PROiQ8IZV5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZV5.
CleanExiHS_RDH10.
ExpressionAtlasiQ8IZV5. baseline and differential.
GenevestigatoriQ8IZV5.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE."
    Wu B.X., Chen Y., Chen Y., Fan J., Rohrer B., Crouch R.K., Ma J.-X.
    Invest. Ophthalmol. Vis. Sci. 43:3365-3372(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene."
    Picozzi P., Marozzi A., Fornasari D., Benfante R., Barisani D., Meneveri R., Ginelli E.
    FEBS Lett. 554:59-66(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiRDH10_HUMAN
AccessioniPrimary (citable) accession number: Q8IZV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.