Q8IZV5 (RDH10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinol dehydrogenase 10
EC=1.1.1.300

Gene names

Name:	RDH10
ORF Names:	UNQ9375/PRO34191

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. Ref.1
Catalytic activity	All-trans-retinol + NADP+ = all-trans-retinal + NADPH. Ref.1
Pathway	Cofactor metabolism; retinol metabolism.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential Ref.1.
Tissue specificity	Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle. Ref.1 Ref.4
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bud elongation involved in lung branching Inferred from electronic annotation. Source: Compara ear development Inferred from electronic annotation. Source: Compara embryonic camera-type eye development Inferred from electronic annotation. Source: Compara embryonic forelimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic viscerocranium morphogenesis Inferred from electronic annotation. Source: Compara gonad development Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara metanephros development Inferred from electronic annotation. Source: Compara neural crest cell development Inferred from electronic annotation. Source: Compara nose development Inferred from electronic annotation. Source: Compara primary lung bud formation Inferred from electronic annotation. Source: Compara retinal metabolic process Inferred from direct assay PubMed 19458327. Source: UniProtKB retinoic acid biosynthetic process Inferred from electronic annotation. Source: Compara retinol metabolic process Inferred from direct assay PubMed 19458327. Source: UniProtKB visual perception Inferred from direct assay Ref.1. Source: MGI
Cellular_component	cell body Inferred from electronic annotation. Source: Compara cytoplasm Inferred from direct assay PubMed 19458327. Source: UniProtKB endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from direct assay PubMed 19458327. Source: UniProtKB
Molecular_function	NADP-retinol dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro retinol dehydrogenase activity Inferred from direct assay PubMed 19458327. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Retinol dehydrogenase 10		PRO_0000307682
Regions
	Transmembrane	3 – 23	21	Helical; Signal-anchor; Potential
	Nucleotide binding	40 – 64	25	NADP By similarity
Sites
	Active site	210	1	Proton acceptor By similarity
	Binding site	197	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8IZV5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D10ABE05E7D11FC6	FASTA	341	38,087
	10 20 30 40 50 60 MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR LFALEFARRR 70 80 90 100 110 120 ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG EEEILPHCNL QVFTYTCDVG 130 140 150 160 170 180 KRENVYLTAE RVRKEVGEVS VLVNNAGVVS GHHLLECPDE LIERTMMVNC HAHFWTTKAF 190 200 210 220 230 240 LPTMLEINHG HIVTVASSLG LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL 250 260 270 280 290 300 VCPYLVDTGM FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK 310 320 330 340 SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE." Wu B.X., Chen Y., Chen Y., Fan J., Rohrer B., Crouch R.K., Ma J.-X. Invest. Ophthalmol. Vis. Sci. 43:3365-3372(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Retina.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[4]	"Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene." Picozzi P., Marozzi A., Fornasari D., Benfante R., Barisani D., Meneveri R., Ginelli E. FEBS Lett. 554:59-66(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF456765 mRNA. Translation: AAN64747.1. AY358270 mRNA. Translation: AAQ88637.1. BC067131 mRNA. Translation: AAH67131.1.
IPI	IPI00218086.
RefSeq	NP_742034.1. NM_172037.4.
UniGene	Hs.244940.
3D structure databases
HSSP	HSSP built from PDB template 1YB1 based on UniProtKB Q8NBQ5.
ProteinModelPortal	Q8IZV5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000240285.
PTM databases
PhosphoSite	Q8IZV5.
Polymorphism databases
DMDM	74750799.
Proteomic databases
PaxDb	Q8IZV5.
PRIDE	Q8IZV5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000240285; ENSP00000240285; ENSG00000121039.
GeneID	157506.
KEGG	hsa:157506.
UCSC	uc003xzi.3. human.
Organism-specific databases
CTD	157506.
GeneCards	GC08P074207.
HGNC	HGNC:19975. RDH10.
MIM	607599. gene.
neXtProt	NX_Q8IZV5.
PharmGKB	PA134989620.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1028.
HOVERGEN	HBG051352.
InParanoid	Q8IZV5.
KO	K11151.
OMA	CTPRIVY.
OrthoDB	EOG43TZVV.
Enzyme and pathway databases
BioCyc	MetaCyc:ENSG00000121039-MONOMER.
BRENDA	1.1.1.105. 2681.
UniPathway	UPA00912.
Gene expression databases
ArrayExpress	Q8IZV5.
Bgee	Q8IZV5.
CleanEx	HS_RDH10.
Genevestigator	Q8IZV5.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	157506.
NextBio	87473.
SOURCE	Search...

Entry information

Entry name

RDH10_HUMAN

Accession

Primary (citable) accession number: Q8IZV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.