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Protein

Retinol dehydrogenase 10

Gene

RDH10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.1 Publication

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.1 Publication

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197SubstrateBy similarity1
Active sitei210Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 64NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • NADP-retinol dehydrogenase activity Source: Reactome
  • retinol dehydrogenase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000121039-MONOMER
BRENDAi1.1.1.105 2681
1.1.1.315 2681
1.1.1.87 2681
ReactomeiR-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-5365859 RA biosynthesis pathway
UniPathwayiUPA00912

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 10 (EC:1.1.1.300)
Alternative name(s):
Short chain dehydrogenase/reductase family 16C member 4
Gene namesi
Name:RDH10
Synonyms:SDR16C4
ORF Names:UNQ9375/PRO34191
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000121039.9
HGNCiHGNC:19975 RDH10
MIMi607599 gene
neXtProtiNX_Q8IZV5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Signal-anchorSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi157506
OpenTargetsiENSG00000121039
PharmGKBiPA134989620

Polymorphism and mutation databases

BioMutaiRDH10
DMDMi74750799

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076821 – 341Retinol dehydrogenase 10Add BLAST341

Proteomic databases

EPDiQ8IZV5
MaxQBiQ8IZV5
PaxDbiQ8IZV5
PeptideAtlasiQ8IZV5
PRIDEiQ8IZV5

PTM databases

iPTMnetiQ8IZV5
PhosphoSitePlusiQ8IZV5

Expressioni

Tissue specificityi

Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000121039
CleanExiHS_RDH10
ExpressionAtlasiQ8IZV5 baseline and differential
GenevisibleiQ8IZV5 HS

Organism-specific databases

HPAiHPA049199

Interactioni

Protein-protein interaction databases

BioGridi127600, 4 interactors
IntActiQ8IZV5, 2 interactors
STRINGi9606.ENSP00000240285

Structurei

3D structure databases

ProteinModelPortaliQ8IZV5
SMRiQ8IZV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00910000143991
HOVERGENiHBG051352
InParanoidiQ8IZV5
KOiK11151
OMAiAKMCWEL
OrthoDBiEOG091G0825
PhylomeDBiQ8IZV5
TreeFamiTF312837

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR032970 RDH10
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PANTHERiPTHR24322:SF731 PTHR24322:SF731, 1 hit
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IZV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR
60 70 80 90 100
LFALEFARRR ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG
110 120 130 140 150
EEEILPHCNL QVFTYTCDVG KRENVYLTAE RVRKEVGEVS VLVNNAGVVS
160 170 180 190 200
GHHLLECPDE LIERTMMVNC HAHFWTTKAF LPTMLEINHG HIVTVASSLG
210 220 230 240 250
LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL VCPYLVDTGM
260 270 280 290 300
FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK
310 320 330 340
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I
Length:341
Mass (Da):38,087
Last modified:March 1, 2003 - v1
Checksum:iD10ABE05E7D11FC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456765 mRNA Translation: AAN64747.1
AY358270 mRNA Translation: AAQ88637.1
BC067131 mRNA Translation: AAH67131.1
CCDSiCCDS6213.1
RefSeqiNP_742034.1, NM_172037.4
UniGeneiHs.244940

Genome annotation databases

EnsembliENST00000240285; ENSP00000240285; ENSG00000121039
GeneIDi157506
KEGGihsa:157506
UCSCiuc003xzi.4 human

Similar proteinsi

Entry informationi

Entry nameiRDH10_HUMAN
AccessioniPrimary (citable) accession number: Q8IZV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health