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Q8IZV5

- RDH10_HUMAN

UniProt

Q8IZV5 - RDH10_HUMAN

Protein

Retinol dehydrogenase 10

Gene

RDH10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.1 Publication

    Catalytic activityi

    All-trans-retinol + NADP+ = all-trans-retinal + NADPH.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei197 – 1971SubstrateBy similarity
    Active sitei210 – 2101Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 6425NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. NADP-retinol dehydrogenase activity Source: UniProtKB-EC
    2. retinol dehydrogenase activity Source: UniProtKB

    GO - Biological processi

    1. bud elongation involved in lung branching Source: Ensembl
    2. ear development Source: Ensembl
    3. embryonic camera-type eye development Source: Ensembl
    4. embryonic forelimb morphogenesis Source: Ensembl
    5. embryonic viscerocranium morphogenesis Source: Ensembl
    6. gonad development Source: Ensembl
    7. in utero embryonic development Source: Ensembl
    8. metanephros development Source: Ensembl
    9. neural crest cell development Source: Ensembl
    10. nose development Source: Ensembl
    11. phototransduction, visible light Source: Reactome
    12. primary lung bud formation Source: Ensembl
    13. retinal metabolic process Source: UniProtKB
    14. retinoic acid biosynthetic process Source: Ensembl
    15. retinoid metabolic process Source: Reactome
    16. retinol metabolic process Source: UniProtKB
    17. visual perception Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000121039-MONOMER.
    BRENDAi1.1.1.105. 2681.
    ReactomeiREACT_160156. The canonical retinoid cycle in rods (twilight vision).
    UniPathwayiUPA00912.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinol dehydrogenase 10 (EC:1.1.1.300)
    Gene namesi
    Name:RDH10
    ORF Names:UNQ9375/PRO34191
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:19975. RDH10.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: Ensembl
    2. cytoplasm Source: UniProtKB
    3. endoplasmic reticulum membrane Source: Reactome
    4. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134989620.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Retinol dehydrogenase 10PRO_0000307682Add
    BLAST

    Proteomic databases

    MaxQBiQ8IZV5.
    PaxDbiQ8IZV5.
    PRIDEiQ8IZV5.

    PTM databases

    PhosphoSiteiQ8IZV5.

    Expressioni

    Tissue specificityi

    Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle.2 Publications

    Gene expression databases

    ArrayExpressiQ8IZV5.
    BgeeiQ8IZV5.
    CleanExiHS_RDH10.
    GenevestigatoriQ8IZV5.

    Interactioni

    Protein-protein interaction databases

    BioGridi127600. 2 interactions.
    STRINGi9606.ENSP00000240285.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZV5.
    SMRiQ8IZV5. Positions 30-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321Helical; Signal-anchorSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG051352.
    InParanoidiQ8IZV5.
    KOiK11151.
    OMAiMNNNEAK.
    OrthoDBiEOG7Z3F50.
    PhylomeDBiQ8IZV5.
    TreeFamiTF312837.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IZV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR    50
    LFALEFARRR ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG 100
    EEEILPHCNL QVFTYTCDVG KRENVYLTAE RVRKEVGEVS VLVNNAGVVS 150
    GHHLLECPDE LIERTMMVNC HAHFWTTKAF LPTMLEINHG HIVTVASSLG 200
    LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL VCPYLVDTGM 250
    FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK 300
    SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I 341
    Length:341
    Mass (Da):38,087
    Last modified:March 1, 2003 - v1
    Checksum:iD10ABE05E7D11FC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF456765 mRNA. Translation: AAN64747.1.
    AY358270 mRNA. Translation: AAQ88637.1.
    BC067131 mRNA. Translation: AAH67131.1.
    CCDSiCCDS6213.1.
    RefSeqiNP_742034.1. NM_172037.4.
    UniGeneiHs.244940.

    Genome annotation databases

    EnsembliENST00000240285; ENSP00000240285; ENSG00000121039.
    GeneIDi157506.
    KEGGihsa:157506.
    UCSCiuc003xzi.3. human.

    Polymorphism databases

    DMDMi74750799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF456765 mRNA. Translation: AAN64747.1 .
    AY358270 mRNA. Translation: AAQ88637.1 .
    BC067131 mRNA. Translation: AAH67131.1 .
    CCDSi CCDS6213.1.
    RefSeqi NP_742034.1. NM_172037.4.
    UniGenei Hs.244940.

    3D structure databases

    ProteinModelPortali Q8IZV5.
    SMRi Q8IZV5. Positions 30-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127600. 2 interactions.
    STRINGi 9606.ENSP00000240285.

    PTM databases

    PhosphoSitei Q8IZV5.

    Polymorphism databases

    DMDMi 74750799.

    Proteomic databases

    MaxQBi Q8IZV5.
    PaxDbi Q8IZV5.
    PRIDEi Q8IZV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240285 ; ENSP00000240285 ; ENSG00000121039 .
    GeneIDi 157506.
    KEGGi hsa:157506.
    UCSCi uc003xzi.3. human.

    Organism-specific databases

    CTDi 157506.
    GeneCardsi GC08P074207.
    HGNCi HGNC:19975. RDH10.
    MIMi 607599. gene.
    neXtProti NX_Q8IZV5.
    PharmGKBi PA134989620.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG051352.
    InParanoidi Q8IZV5.
    KOi K11151.
    OMAi MNNNEAK.
    OrthoDBi EOG7Z3F50.
    PhylomeDBi Q8IZV5.
    TreeFami TF312837.

    Enzyme and pathway databases

    UniPathwayi UPA00912 .
    BioCyci MetaCyc:ENSG00000121039-MONOMER.
    BRENDAi 1.1.1.105. 2681.
    Reactomei REACT_160156. The canonical retinoid cycle in rods (twilight vision).

    Miscellaneous databases

    GenomeRNAii 157506.
    NextBioi 87473.
    PROi Q8IZV5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZV5.
    Bgeei Q8IZV5.
    CleanExi HS_RDH10.
    Genevestigatori Q8IZV5.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE."
      Wu B.X., Chen Y., Chen Y., Fan J., Rohrer B., Crouch R.K., Ma J.-X.
      Invest. Ophthalmol. Vis. Sci. 43:3365-3372(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Retina.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. "Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene."
      Picozzi P., Marozzi A., Fornasari D., Benfante R., Barisani D., Meneveri R., Ginelli E.
      FEBS Lett. 554:59-66(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRDH10_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3