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Protein

CKLF-like MARVEL transmembrane domain-containing protein 8

Gene

CMTM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 8
Alternative name(s):
Chemokine-like factor superfamily member 8
Gene namesi
Name:CMTM8
Synonyms:CKLFSF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19179. CMTM8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38818.

Polymorphism and mutation databases

BioMutaiCMTM8.
DMDMi145559454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173CKLF-like MARVEL transmembrane domain-containing protein 8PRO_0000186112Add
BLAST

Proteomic databases

MaxQBiQ8IZV2.
PaxDbiQ8IZV2.
PeptideAtlasiQ8IZV2.
PRIDEiQ8IZV2.

PTM databases

iPTMnetiQ8IZV2.
PhosphoSiteiQ8IZV2.

Expressioni

Tissue specificityi

Highly expressed in liver and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000170293.
CleanExiHS_CMTM8.
GenevisibleiQ8IZV2. HS.

Organism-specific databases

HPAiHPA055077.
HPA073258.

Interactioni

Protein-protein interaction databases

MINTiMINT-1489560.
STRINGi9606.ENSP00000307741.

Structurei

3D structure databases

ProteinModelPortaliQ8IZV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 168133MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110954.
HOGENOMiHOG000247057.
HOVERGENiHBG108271.
InParanoidiQ8IZV2.
OMAiYFSFISW.
OrthoDBiEOG091G0RE7.
PhylomeDBiQ8IZV2.
TreeFamiTF316174.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEPQRARSH TVTTTASSFA ENFSTSSSSF AYDREFLRTL PGFLIVAEIV
60 70 80 90 100
LGLLVWTLIA GTEYFRVPAF GWVMFVAVFY WVLTVFFLII YITMTYTRIP
110 120 130 140 150
QVPWTTVGLC FNGSAFVLYL SAAVVDASSV SPERDSHNFN SWAASSFFAF
160 170
LVTICYAGNT YFSFIAWRSR TIQ
Length:173
Mass (Da):19,572
Last modified:April 17, 2007 - v2
Checksum:i30566423F2A6F600
GO
Isoform 2 (identifier: Q8IZV2-2) [UniParc]FASTAAdd to basket
Also known as: CMTM8-v2

The sequence of this isoform differs from the canonical sequence as follows:
     50-107: Missing.

Show »
Length:115
Mass (Da):12,739
Checksum:iC71759239F5763AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241S → F in AAN73034 (PubMed:12782130).Curated
Sequence conflicti41 – 411P → H in AAH41390 (PubMed:15489334).Curated
Sequence conflicti79 – 791F → S in AAH41390 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei50 – 10758Missing in isoform 2. 1 PublicationVSP_044430Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF474370 mRNA. Translation: AAN73034.1.
AY598783 mRNA. Translation: AAT11020.1.
AC097639 Genomic DNA. No translation available.
AC103558 Genomic DNA. No translation available.
BC041390 mRNA. Translation: AAH41390.1.
CCDSiCCDS2652.1. [Q8IZV2-1]
RefSeqiNP_001307237.1. NM_001320308.1. [Q8IZV2-2]
NP_849199.2. NM_178868.4. [Q8IZV2-1]
UniGeneiHs.154986.

Genome annotation databases

EnsembliENST00000307526; ENSP00000307741; ENSG00000170293. [Q8IZV2-1]
ENST00000458535; ENSP00000412934; ENSG00000170293. [Q8IZV2-2]
GeneIDi152189.
KEGGihsa:152189.
UCSCiuc003cex.4. human. [Q8IZV2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF474370 mRNA. Translation: AAN73034.1.
AY598783 mRNA. Translation: AAT11020.1.
AC097639 Genomic DNA. No translation available.
AC103558 Genomic DNA. No translation available.
BC041390 mRNA. Translation: AAH41390.1.
CCDSiCCDS2652.1. [Q8IZV2-1]
RefSeqiNP_001307237.1. NM_001320308.1. [Q8IZV2-2]
NP_849199.2. NM_178868.4. [Q8IZV2-1]
UniGeneiHs.154986.

3D structure databases

ProteinModelPortaliQ8IZV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1489560.
STRINGi9606.ENSP00000307741.

PTM databases

iPTMnetiQ8IZV2.
PhosphoSiteiQ8IZV2.

Polymorphism and mutation databases

BioMutaiCMTM8.
DMDMi145559454.

Proteomic databases

MaxQBiQ8IZV2.
PaxDbiQ8IZV2.
PeptideAtlasiQ8IZV2.
PRIDEiQ8IZV2.

Protocols and materials databases

DNASUi152189.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307526; ENSP00000307741; ENSG00000170293. [Q8IZV2-1]
ENST00000458535; ENSP00000412934; ENSG00000170293. [Q8IZV2-2]
GeneIDi152189.
KEGGihsa:152189.
UCSCiuc003cex.4. human. [Q8IZV2-1]

Organism-specific databases

CTDi152189.
GeneCardsiCMTM8.
H-InvDBHIX0024291.
HGNCiHGNC:19179. CMTM8.
HPAiHPA055077.
HPA073258.
MIMi607891. gene.
neXtProtiNX_Q8IZV2.
PharmGKBiPA38818.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110954.
HOGENOMiHOG000247057.
HOVERGENiHBG108271.
InParanoidiQ8IZV2.
OMAiYFSFISW.
OrthoDBiEOG091G0RE7.
PhylomeDBiQ8IZV2.
TreeFamiTF316174.

Miscellaneous databases

GenomeRNAii152189.
PROiQ8IZV2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170293.
CleanExiHS_CMTM8.
GenevisibleiQ8IZV2. HS.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKLF8_HUMAN
AccessioniPrimary (citable) accession number: Q8IZV2
Secondary accession number(s): A5D6I7, Q8IW01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.