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Protein

Dermatan-sulfate epimerase-like protein

Gene

DSEL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BRENDAi5.1.3.19. 2681.
ReactomeiR-HSA-2022923. Dermatan sulfate biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Dermatan-sulfate epimerase-like protein (EC:5.1.-.-)
Gene namesi
Name:DSEL
Synonyms:C18orf4, NCAG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:18144. DSEL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei764 – 784HelicalSequence analysisAdd BLAST21
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi92126.
PharmGKBiPA162384097.

Polymorphism and mutation databases

BioMutaiDSEL.
DMDMi126215700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000027828821 – 1212Dermatan-sulfate epimerase-like proteinAdd BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Glycosylationi666N-linked (GlcNAc...)Sequence analysis1
Glycosylationi688N-linked (GlcNAc...)Sequence analysis1
Glycosylationi709N-linked (GlcNAc...)Sequence analysis1
Glycosylationi874N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IZU8.
MaxQBiQ8IZU8.
PaxDbiQ8IZU8.
PeptideAtlasiQ8IZU8.
PRIDEiQ8IZU8.

PTM databases

iPTMnetiQ8IZU8.
PhosphoSitePlusiQ8IZU8.

Expressioni

Tissue specificityi

Expressed in different brain areas as well as in multiple other peripheral tissues.1 Publication

Gene expression databases

BgeeiENSG00000171451.
CleanExiHS_DSEL.
GenevisibleiQ8IZU8. HS.

Interactioni

Protein-protein interaction databases

BioGridi124911. 1 interactor.
STRINGi9606.ENSP00000310565.

Structurei

3D structure databases

ProteinModelPortaliQ8IZU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dermatan-sulfate isomerase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE6W. Eukaryota.
ENOG410Y713. LUCA.
HOGENOMiHOG000060116.
HOVERGENiHBG081464.
InParanoidiQ8IZU8.
OrthoDBiEOG091G01JO.
PhylomeDBiQ8IZU8.
TreeFamiTF334118.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALMFTGHLL FLALLMFAFS TFEESVSNYS EWAVFTDDID QFKTQKVQDF
60 70 80 90 100
RPNQKLKKSM LHPSLYFDAG EIQAMRQKSR ASHLHLFRAI RSAVTVMLSN
110 120 130 140 150
PTYYLPPPKH ADFAAKWNEI YGNNLPPLAL YCLLCPEDKV AFEFVLEYMD
160 170 180 190 200
RMVGYKDWLV ENAPGDEVPI GHSLTGFATA FDFLYNLLDN HRRQKYLEKI
210 220 230 240 250
WVITEEMYEY SKVRSWGKQL LHNHQATNMI ALLTGALVTG VDKGSKANIW
260 270 280 290 300
KQAVVDVMEK TMFLLNHIVD GSLDEGVAYG SYTAKSVTQY VFLAQRHFNI
310 320 330 340 350
NNLDNNWLKM HFWFYYATLL PGFQRTVGIA DSNYNWFYGP ESQLVFLDKF
360 370 380 390 400
ILKNGAGNWL AQQIRKHRPK DGPMVPSTAQ RWSTLHTEYI WYDPQLTPQP
410 420 430 440 450
PADYGTAKIH TFPNWGVVTY GAGLPNTQTN TFVSFKSGKL GGRAVYDIVH
460 470 480 490 500
FQPYSWIDGW RSFNPGHEHP DQNSFTFAPN GQVFVSEALY GPKLSHLNNV
510 520 530 540 550
LVFAPSPSSQ CNKPWEGQLG ECAQWLKWTG EEVGDAAGEI ITASQHGEMV
560 570 580 590 600
FVSGEAVSAY SSAMRLKSVY RALLLLNSQT LLVVDHIERQ EDSPINSVSA
610 620 630 640 650
FFHNLDIDFK YIPYKFMNRY NGAMMDVWDA HYKMFWFDHH GNSPMASIQE
660 670 680 690 700
AEQAAEFKKR WTQFVNVTFQ MEPTITRIAY VFYGPYINVS SCRFIDSSNP
710 720 730 740 750
GLQISLNVNN TEHVVSIVTD YHNLKTRFNY LGFGGFASVA DQGQITRFGL
760 770 780 790 800
GTQAIVKPVR HDRIIFPFGF KFNIAVGLIL CISLVILTFQ WRFYLSFRKL
810 820 830 840 850
MRWILILVIA LWFIELLDVW STCSQPICAK WTRTEAEGSK KSLSSEGHHM
860 870 880 890 900
DLPDVVITSL PGSGAEILKQ LFFNSSDFLY IRVPTAYIDI PETELEIDSF
910 920 930 940 950
VDACEWKVSD IRSGHFRLLR GWLQSLVQDT KLHLQNIHLH EPNRGKLAQY
960 970 980 990 1000
FAMNKDKKRK FKRRESLPEQ RSQMKGAFDR DAEYIRALRR HLVYYPSARP
1010 1020 1030 1040 1050
VLSLSSGSWT LKLHFFQEVL GASMRALYIV RDPRAWIYSM LYNSKPSLYS
1060 1070 1080 1090 1100
LKNVPEHLAK LFKIEGGKGK CNLNSGYAFE YEPLRKELSK SKSNAVSLLS
1110 1120 1130 1140 1150
HLWLANTAAA LRINTDLLPT SYQLVKFEDI VHFPQKTTER IFAFLGIPLS
1160 1170 1180 1190 1200
PASLNQILFA TSTNLFYLPY EGEISPTNTN VWKQNLPRDE IKLIENICWT
1210
LMDRLGYPKF MD
Length:1,212
Mass (Da):139,238
Last modified:February 20, 2007 - v2
Checksum:iB3C52221661234BD
GO

Sequence cautioni

The sequence AAI17326 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAN32895 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188Missing in AAI17326 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030833673P → S.Corresponds to variant rs2279269dbSNPEnsembl.1
Natural variantiVAR_030834730Y → C.Corresponds to variant rs12953840dbSNPEnsembl.1
Natural variantiVAR_057759832T → S.Corresponds to variant rs35479856dbSNPEnsembl.1
Natural variantiVAR_0365281090K → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480435 mRNA. Translation: AAN32895.1. Different initiation.
AC110597 Genomic DNA. No translation available.
BC062557 mRNA. Translation: AAH62557.1. Different termination.
BC117325 mRNA. Translation: AAI17326.1. Different initiation.
RefSeqiNP_115536.1. NM_032160.2.
UniGeneiHs.124673.

Genome annotation databases

EnsembliENST00000310045; ENSP00000310565; ENSG00000171451.
ENST00000572659; ENSP00000460321; ENSG00000262102.
GeneIDi92126.
KEGGihsa:92126.
UCSCiuc002lke.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480435 mRNA. Translation: AAN32895.1. Different initiation.
AC110597 Genomic DNA. No translation available.
BC062557 mRNA. Translation: AAH62557.1. Different termination.
BC117325 mRNA. Translation: AAI17326.1. Different initiation.
RefSeqiNP_115536.1. NM_032160.2.
UniGeneiHs.124673.

3D structure databases

ProteinModelPortaliQ8IZU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124911. 1 interactor.
STRINGi9606.ENSP00000310565.

PTM databases

iPTMnetiQ8IZU8.
PhosphoSitePlusiQ8IZU8.

Polymorphism and mutation databases

BioMutaiDSEL.
DMDMi126215700.

Proteomic databases

EPDiQ8IZU8.
MaxQBiQ8IZU8.
PaxDbiQ8IZU8.
PeptideAtlasiQ8IZU8.
PRIDEiQ8IZU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310045; ENSP00000310565; ENSG00000171451.
ENST00000572659; ENSP00000460321; ENSG00000262102.
GeneIDi92126.
KEGGihsa:92126.
UCSCiuc002lke.2. human.

Organism-specific databases

CTDi92126.
DisGeNETi92126.
GeneCardsiDSEL.
HGNCiHGNC:18144. DSEL.
MIMi611125. gene.
neXtProtiNX_Q8IZU8.
PharmGKBiPA162384097.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE6W. Eukaryota.
ENOG410Y713. LUCA.
HOGENOMiHOG000060116.
HOVERGENiHBG081464.
InParanoidiQ8IZU8.
OrthoDBiEOG091G01JO.
PhylomeDBiQ8IZU8.
TreeFamiTF334118.

Enzyme and pathway databases

BRENDAi5.1.3.19. 2681.
ReactomeiR-HSA-2022923. Dermatan sulfate biosynthesis.

Miscellaneous databases

GenomeRNAii92126.
PROiQ8IZU8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171451.
CleanExiHS_DSEL.
GenevisibleiQ8IZU8. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDSEL_HUMAN
AccessioniPrimary (citable) accession number: Q8IZU8
Secondary accession number(s): Q17RH1, Q6P5Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.