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Q8IZU3

- SYCP3_HUMAN

UniProt

Q8IZU3 - SYCP3_HUMAN

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Protein

Synaptonemal complex protein 3

Gene
SYCP3, SCP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 By similarity.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. male meiosis I Source: UniProtKB
  2. spermatogenesis, exchange of chromosomal proteins Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Meiosis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_75792. Meiotic synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex protein 3
Short name:
SCP-3
Gene namesi
Name:SYCP3
Synonyms:SCP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:18130. SYCP3.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity
Note: In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed By similarity.

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi270960. phenotype.
Orphaneti217034. Male infertility with normal virilization due to meiosis defect.
PharmGKBiPA38298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Synaptonemal complex protein 3PRO_0000229024Add
BLAST

Post-translational modificationi

Phosphorylated By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IZU3.
PRIDEiQ8IZU3.

PTM databases

PhosphoSiteiQ8IZU3.

Expressioni

Tissue specificityi

Testis-specific.2 Publications

Gene expression databases

BgeeiQ8IZU3.
CleanExiHS_SYCP3.
GenevestigatoriQ8IZU3.

Organism-specific databases

HPAiCAB032978.
HPA039635.
HPA043938.

Interactioni

Subunit structurei

Interacts with SYCP2 By similarity.

Protein-protein interaction databases

BioGridi119081. 4 interactions.
DIPiDIP-59536N.
IntActiQ8IZU3. 1 interaction.
MINTiMINT-8303450.
STRINGi9606.ENSP00000266743.

Structurei

3D structure databases

ProteinModelPortaliQ8IZU3.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili139 – 22385 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi88 – 914Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi105 – 232128Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the XLR/SYCP3 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG27405.
HOGENOMiHOG000236293.
HOVERGENiHBG100390.
InParanoidiQ8IZU3.
OMAiVFQQSRI.
OrthoDBiEOG7C2R2F.
PhylomeDBiQ8IZU3.
TreeFamiTF328876.

Family and domain databases

InterProiIPR006888. Cor1/Xlr/Xmr.
[Graphical view]
PANTHERiPTHR19368. PTHR19368. 1 hit.
PfamiPF04803. Cor1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZU3-1 [UniParc]FASTAAdd to Basket

« Hide

MVSSGKKYSR KSGKPSVEDQ FTRAYDFETE DKKDLSGSEE DVIEGKTAVI    50
EKRRKKRSSA GVVEDMGGEV QNMLEGVGVD INKALLAKRK RLEMYTKASL 100
KTSNQKIEHV WKTQQDQRQK LNQEYSQQFL TLFQQWDLDM QKAEEQEEKI 150
LNMFRQQQKI LQQSRIVQSQ RLKTIKQLYE QFIKSMEELE KNHDNLLTGA 200
QNEFKKEMAM LQKKIMMETQ QQEIASVRKS LQSMLF 236
Length:236
Mass (Da):27,729
Last modified:March 1, 2003 - v1
Checksum:iD871B6AEA279ABDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF492003 mRNA. Translation: AAN06611.1.
AF517774 mRNA. Translation: AAP47204.1.
BC062662 mRNA. Translation: AAH62662.1.
CCDSiCCDS9087.1.
RefSeqiNP_001171419.1. NM_001177948.1.
NP_001171420.1. NM_001177949.1.
NP_710161.1. NM_153694.4.
UniGeneiHs.506504.

Genome annotation databases

EnsembliENST00000266743; ENSP00000266743; ENSG00000139351.
ENST00000392924; ENSP00000376655; ENSG00000139351.
ENST00000392927; ENSP00000376658; ENSG00000139351.
GeneIDi50511.
KEGGihsa:50511.
UCSCiuc001tiq.3. human.

Polymorphism databases

DMDMi74728444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF492003 mRNA. Translation: AAN06611.1 .
AF517774 mRNA. Translation: AAP47204.1 .
BC062662 mRNA. Translation: AAH62662.1 .
CCDSi CCDS9087.1.
RefSeqi NP_001171419.1. NM_001177948.1.
NP_001171420.1. NM_001177949.1.
NP_710161.1. NM_153694.4.
UniGenei Hs.506504.

3D structure databases

ProteinModelPortali Q8IZU3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119081. 4 interactions.
DIPi DIP-59536N.
IntActi Q8IZU3. 1 interaction.
MINTi MINT-8303450.
STRINGi 9606.ENSP00000266743.

PTM databases

PhosphoSitei Q8IZU3.

Polymorphism databases

DMDMi 74728444.

Proteomic databases

PaxDbi Q8IZU3.
PRIDEi Q8IZU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266743 ; ENSP00000266743 ; ENSG00000139351 .
ENST00000392924 ; ENSP00000376655 ; ENSG00000139351 .
ENST00000392927 ; ENSP00000376658 ; ENSG00000139351 .
GeneIDi 50511.
KEGGi hsa:50511.
UCSCi uc001tiq.3. human.

Organism-specific databases

CTDi 50511.
GeneCardsi GC12M102105.
HGNCi HGNC:18130. SYCP3.
HPAi CAB032978.
HPA039635.
HPA043938.
MIMi 270960. phenotype.
604759. gene.
neXtProti NX_Q8IZU3.
Orphaneti 217034. Male infertility with normal virilization due to meiosis defect.
PharmGKBi PA38298.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27405.
HOGENOMi HOG000236293.
HOVERGENi HBG100390.
InParanoidi Q8IZU3.
OMAi VFQQSRI.
OrthoDBi EOG7C2R2F.
PhylomeDBi Q8IZU3.
TreeFami TF328876.

Enzyme and pathway databases

Reactomei REACT_75792. Meiotic synapsis.

Miscellaneous databases

GeneWikii SYCP3.
GenomeRNAii 50511.
NextBioi 53082.
PROi Q8IZU3.
SOURCEi Search...

Gene expression databases

Bgeei Q8IZU3.
CleanExi HS_SYCP3.
Genevestigatori Q8IZU3.

Family and domain databases

InterProi IPR006888. Cor1/Xlr/Xmr.
[Graphical view ]
PANTHERi PTHR19368. PTHR19368. 1 hit.
Pfami PF04803. Cor1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region."
    Martinez-Garay I., Jablonka S., Sutajova M., Steuernagel P., Gal A., Kutsche K.
    Genomics 80:259-267(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "A notch-related gene located on the long arm of human chromosome 12."
    Adamah D.J.B., Gokhale P.J., Walsh J., Andrews P.W., Martinez Garay I., Kutsche K.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Azoospermia in patients heterozygous for a mutation in SYCP3."
    Miyamoto T., Hasuike S., Yogev L., Maduro M.R., Ishikawa M., Westphal H., Lamb D.J.
    Lancet 362:1714-1719(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN SPGF4.

Entry informationi

Entry nameiSYCP3_HUMAN
AccessioniPrimary (citable) accession number: Q8IZU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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