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Q8IZU3 (SYCP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptonemal complex protein 3

Short name=SCP-3
Gene names
Name:SYCP3
Synonyms:SCP3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 By similarity. Ref.4

Subunit structure

Interacts with SYCP2 By similarity.

Subcellular location

Nucleus By similarity. Chromosome By similarity. Note: In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed By similarity.

Tissue specificity

Testis-specific. Ref.1 Ref.4

Post-translational modification

Phosphorylated By similarity.

Involvement in disease

Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4

Sequence similarities

Belongs to the XLR/SYCP3 family.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Meiosis
   Cellular componentChromosome
Nucleus
   DomainCoiled coil
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell division

Inferred from electronic annotation. Source: UniProtKB-KW

male meiosis I

Non-traceable author statement PubMed 15218256. Source: UniProtKB

spermatogenesis, exchange of chromosomal proteins

Inferred from mutant phenotype Ref.4. Source: UniProtKB

   Cellular_componentchromosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Synaptonemal complex protein 3
PRO_0000229024

Regions

Coiled coil139 – 22385 Potential
Motif88 – 914Nuclear localization signal Potential
Compositional bias105 – 232128Gln-rich

Sequences

Sequence LengthMass (Da)Tools
Q8IZU3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: D871B6AEA279ABDD

FASTA23627,729
        10         20         30         40         50         60 
MVSSGKKYSR KSGKPSVEDQ FTRAYDFETE DKKDLSGSEE DVIEGKTAVI EKRRKKRSSA 

        70         80         90        100        110        120 
GVVEDMGGEV QNMLEGVGVD INKALLAKRK RLEMYTKASL KTSNQKIEHV WKTQQDQRQK 

       130        140        150        160        170        180 
LNQEYSQQFL TLFQQWDLDM QKAEEQEEKI LNMFRQQQKI LQQSRIVQSQ RLKTIKQLYE 

       190        200        210        220        230 
QFIKSMEELE KNHDNLLTGA QNEFKKEMAM LQKKIMMETQ QQEIASVRKS LQSMLF 

« Hide

References

« Hide 'large scale' references
[1]"A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region."
Martinez-Garay I., Jablonka S., Sutajova M., Steuernagel P., Gal A., Kutsche K.
Genomics 80:259-267(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"A notch-related gene located on the long arm of human chromosome 12."
Adamah D.J.B., Gokhale P.J., Walsh J., Andrews P.W., Martinez Garay I., Kutsche K.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Azoospermia in patients heterozygous for a mutation in SYCP3."
Miyamoto T., Hasuike S., Yogev L., Maduro M.R., Ishikawa M., Westphal H., Lamb D.J.
Lancet 362:1714-1719(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN SPGF4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF492003 mRNA. Translation: AAN06611.1.
AF517774 mRNA. Translation: AAP47204.1.
BC062662 mRNA. Translation: AAH62662.1.
RefSeqNP_001171419.1. NM_001177948.1.
NP_001171420.1. NM_001177949.1.
NP_710161.1. NM_153694.4.
UniGeneHs.506504.

3D structure databases

ProteinModelPortalQ8IZU3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119081. 4 interactions.
DIPDIP-59536N.
IntActQ8IZU3. 1 interaction.
MINTMINT-8303450.
STRING9606.ENSP00000266743.

PTM databases

PhosphoSiteQ8IZU3.

Polymorphism databases

DMDM74728444.

Proteomic databases

PaxDbQ8IZU3.
PRIDEQ8IZU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266743; ENSP00000266743; ENSG00000139351.
ENST00000392924; ENSP00000376655; ENSG00000139351.
ENST00000392927; ENSP00000376658; ENSG00000139351.
GeneID50511.
KEGGhsa:50511.
UCSCuc001tiq.3. human.

Organism-specific databases

CTD50511.
GeneCardsGC12M102105.
HGNCHGNC:18130. SYCP3.
HPACAB032978.
HPA039635.
HPA043938.
MIM270960. phenotype.
604759. gene.
neXtProtNX_Q8IZU3.
Orphanet217034. Male infertility with normal virilization due to meiosis defect.
PharmGKBPA38298.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG27405.
HOGENOMHOG000236293.
HOVERGENHBG100390.
InParanoidQ8IZU3.
OMAVFQQSRI.
OrthoDBEOG7C2R2F.
PhylomeDBQ8IZU3.
TreeFamTF328876.

Enzyme and pathway databases

ReactomeREACT_111183. Meiosis.
REACT_115566. Cell Cycle.

Gene expression databases

BgeeQ8IZU3.
CleanExHS_SYCP3.
GenevestigatorQ8IZU3.

Family and domain databases

InterProIPR006888. Cor1/Xlr/Xmr.
[Graphical view]
PANTHERPTHR19368. PTHR19368. 1 hit.
PfamPF04803. Cor1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSYCP3.
GenomeRNAi50511.
NextBio53082.
PROQ8IZU3.
SOURCESearch...

Entry information

Entry nameSYCP3_HUMAN
AccessionPrimary (citable) accession number: Q8IZU3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM