Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8IZU3

- SYCP3_HUMAN

UniProt

Q8IZU3 - SYCP3_HUMAN

Protein

Synaptonemal complex protein 3

Gene

SYCP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. male meiosis I Source: UniProtKB
    2. spermatogenesis, exchange of chromosomal proteins Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Meiosis

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_75792. Meiotic synapsis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptonemal complex protein 3
    Short name:
    SCP-3
    Gene namesi
    Name:SYCP3
    Synonyms:SCP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:18130. SYCP3.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity
    Note: In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed.By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi270960. phenotype.
    Orphaneti217034. Male infertility with normal virilization due to meiosis defect.
    PharmGKBiPA38298.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236Synaptonemal complex protein 3PRO_0000229024Add
    BLAST

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8IZU3.
    PRIDEiQ8IZU3.

    PTM databases

    PhosphoSiteiQ8IZU3.

    Expressioni

    Tissue specificityi

    Testis-specific.2 Publications

    Gene expression databases

    BgeeiQ8IZU3.
    CleanExiHS_SYCP3.
    GenevestigatoriQ8IZU3.

    Organism-specific databases

    HPAiCAB032978.
    HPA039635.
    HPA043938.

    Interactioni

    Subunit structurei

    Interacts with SYCP2.By similarity

    Protein-protein interaction databases

    BioGridi119081. 4 interactions.
    DIPiDIP-59536N.
    IntActiQ8IZU3. 1 interaction.
    MINTiMINT-8303450.
    STRINGi9606.ENSP00000266743.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili139 – 22385Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi88 – 914Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi105 – 232128Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the XLR/SYCP3 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG27405.
    HOGENOMiHOG000236293.
    HOVERGENiHBG100390.
    InParanoidiQ8IZU3.
    OMAiVFQQSRI.
    OrthoDBiEOG7C2R2F.
    PhylomeDBiQ8IZU3.
    TreeFamiTF328876.

    Family and domain databases

    InterProiIPR006888. Cor1/Xlr/Xmr.
    [Graphical view]
    PANTHERiPTHR19368. PTHR19368. 1 hit.
    PfamiPF04803. Cor1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IZU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSSGKKYSR KSGKPSVEDQ FTRAYDFETE DKKDLSGSEE DVIEGKTAVI    50
    EKRRKKRSSA GVVEDMGGEV QNMLEGVGVD INKALLAKRK RLEMYTKASL 100
    KTSNQKIEHV WKTQQDQRQK LNQEYSQQFL TLFQQWDLDM QKAEEQEEKI 150
    LNMFRQQQKI LQQSRIVQSQ RLKTIKQLYE QFIKSMEELE KNHDNLLTGA 200
    QNEFKKEMAM LQKKIMMETQ QQEIASVRKS LQSMLF 236
    Length:236
    Mass (Da):27,729
    Last modified:March 1, 2003 - v1
    Checksum:iD871B6AEA279ABDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF492003 mRNA. Translation: AAN06611.1.
    AF517774 mRNA. Translation: AAP47204.1.
    BC062662 mRNA. Translation: AAH62662.1.
    CCDSiCCDS9087.1.
    RefSeqiNP_001171419.1. NM_001177948.1.
    NP_001171420.1. NM_001177949.1.
    NP_710161.1. NM_153694.4.
    UniGeneiHs.506504.

    Genome annotation databases

    EnsembliENST00000266743; ENSP00000266743; ENSG00000139351.
    ENST00000392924; ENSP00000376655; ENSG00000139351.
    ENST00000392927; ENSP00000376658; ENSG00000139351.
    GeneIDi50511.
    KEGGihsa:50511.
    UCSCiuc001tiq.3. human.

    Polymorphism databases

    DMDMi74728444.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF492003 mRNA. Translation: AAN06611.1 .
    AF517774 mRNA. Translation: AAP47204.1 .
    BC062662 mRNA. Translation: AAH62662.1 .
    CCDSi CCDS9087.1.
    RefSeqi NP_001171419.1. NM_001177948.1.
    NP_001171420.1. NM_001177949.1.
    NP_710161.1. NM_153694.4.
    UniGenei Hs.506504.

    3D structure databases

    ProteinModelPortali Q8IZU3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119081. 4 interactions.
    DIPi DIP-59536N.
    IntActi Q8IZU3. 1 interaction.
    MINTi MINT-8303450.
    STRINGi 9606.ENSP00000266743.

    PTM databases

    PhosphoSitei Q8IZU3.

    Polymorphism databases

    DMDMi 74728444.

    Proteomic databases

    PaxDbi Q8IZU3.
    PRIDEi Q8IZU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266743 ; ENSP00000266743 ; ENSG00000139351 .
    ENST00000392924 ; ENSP00000376655 ; ENSG00000139351 .
    ENST00000392927 ; ENSP00000376658 ; ENSG00000139351 .
    GeneIDi 50511.
    KEGGi hsa:50511.
    UCSCi uc001tiq.3. human.

    Organism-specific databases

    CTDi 50511.
    GeneCardsi GC12M102105.
    HGNCi HGNC:18130. SYCP3.
    HPAi CAB032978.
    HPA039635.
    HPA043938.
    MIMi 270960. phenotype.
    604759. gene.
    neXtProti NX_Q8IZU3.
    Orphaneti 217034. Male infertility with normal virilization due to meiosis defect.
    PharmGKBi PA38298.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG27405.
    HOGENOMi HOG000236293.
    HOVERGENi HBG100390.
    InParanoidi Q8IZU3.
    OMAi VFQQSRI.
    OrthoDBi EOG7C2R2F.
    PhylomeDBi Q8IZU3.
    TreeFami TF328876.

    Enzyme and pathway databases

    Reactomei REACT_75792. Meiotic synapsis.

    Miscellaneous databases

    GeneWikii SYCP3.
    GenomeRNAii 50511.
    NextBioi 53082.
    PROi Q8IZU3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IZU3.
    CleanExi HS_SYCP3.
    Genevestigatori Q8IZU3.

    Family and domain databases

    InterProi IPR006888. Cor1/Xlr/Xmr.
    [Graphical view ]
    PANTHERi PTHR19368. PTHR19368. 1 hit.
    Pfami PF04803. Cor1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region."
      Martinez-Garay I., Jablonka S., Sutajova M., Steuernagel P., Gal A., Kutsche K.
      Genomics 80:259-267(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "A notch-related gene located on the long arm of human chromosome 12."
      Adamah D.J.B., Gokhale P.J., Walsh J., Andrews P.W., Martinez Garay I., Kutsche K.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Azoospermia in patients heterozygous for a mutation in SYCP3."
      Miyamoto T., Hasuike S., Yogev L., Maduro M.R., Ishikawa M., Westphal H., Lamb D.J.
      Lancet 362:1714-1719(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN SPGF4.

    Entry informationi

    Entry nameiSYCP3_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3