Q8IZU2 (WDR17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 17

Gene names

Name:

WDR17

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1322 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 12 WD repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1322	1322	WD repeat-containing protein 17		PRO_0000051364
Regions
	Repeat	81 – 121	41	WD 1
	Repeat	123 – 164	42	WD 2
	Repeat	171 – 211	41	WD 3
	Repeat	221 – 261	41	WD 4
	Repeat	266 – 307	42	WD 5
	Repeat	391 – 431	41	WD 6
	Repeat	434 – 474	41	WD 7
	Repeat	478 – 518	41	WD 8
	Repeat	519 – 559	41	WD 9
	Repeat	564 – 604	41	WD 10
	Repeat	607 – 647	41	WD 11
	Repeat	650 – 690	41	WD 12
Natural variations
	Natural variant	418	1	I → V. Corresponds to variant rs59567138 [ dbSNP | Ensembl ].		VAR_062101
	Natural variant	814	1	A → T. Corresponds to variant rs4690661 [ dbSNP | Ensembl ].		VAR_047399
	Natural variant	913	1	C → S. Corresponds to variant rs7693453 [ dbSNP | Ensembl ].		VAR_047400
	Natural variant	952	1	E → K. Corresponds to variant rs6810394 [ dbSNP | Ensembl ].		VAR_047401
	Natural variant	1215	1	A → T. Corresponds to variant rs17625943 [ dbSNP | Ensembl ].		VAR_047402
	Natural variant	1295	1	A → T. Ref.1 Corresponds to variant rs11736872 [ dbSNP | Ensembl ].		VAR_047403

Sequences

	Sequence		Length	Mass (Da)
	Q8IZU2 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 99FFCE51B9EA8175	FASTA	1,322	147,703
	10 20 30 40 50 60 MAWMTYISNW FEQDDWYEGL QRANMSQVRQ VGLLAAGCQP WNKDVCAASG DRFAYCATLA 70 80 90 100 110 120 IYIYQLDHRY NEFKLHAIMS EHKKTITAIS WCPHNPDLFA SGSTDNLVII WNVAEQKVIA 130 140 150 160 170 180 KLDSTKGIPA SLSWCWNAED VVAFVSHRGP LFIWTISGPD SGVIVHKDAH SFLSDICMFR 190 200 210 220 230 240 WHTHQKGKVV FGHIDGSLSI FHPGNKNQKH VLRPESLEGT DEEDPVTALE WDPLSTDYLL 250 260 270 280 290 300 VVNLHYGIRL VDSESLSCIT TFNLPSAAAS VQCLAWVPSA PGMFITGDSQ VGVLRIWNVS 310 320 330 340 350 360 RTTPIDNLKL KKTGFHCLHV LNSPPRKKFS VQSPTKNHYT SSTSEAVPPP TLTQNQAFSL 370 380 390 400 410 420 PPGHAVCCFL DGGVGLYDMG AKKWDFLRDL GHVETIFDCK FKPDDPNLLA TASFDGTIKV 430 440 450 460 470 480 WDINTLTAVY TSPGNEGVIY SLSWAPGGLN CIAGGTSRNG AFIWNVQKGK IIQRFNEHGT 490 500 510 520 530 540 NGIFCIAWSH KDSKRIATCS SDGFCIIRTI DGKVLHKYKH PAAVFGCDWS QNNKDMIATG 550 560 570 580 590 600 CEDTNVRVYY VATSSDQPLK VFSGHTAKVF HVKWSPLREG ILCSGSDDGT VRIWDYTQDA 610 620 630 640 650 660 CINILNGHTA PVRGLMWNTE IPYLLISGSW DYTIKVWDTR EGTCVDTVYD HGADVYGLTC 670 680 690 700 710 720 HPSRPFTMAS CSRDSTVRLW SLTALVTPVQ INILADRSWE EIIGNTDYAI EPGTPPLLCG 730 740 750 760 770 780 KVSRDIRQEI EKLTANSQVK KLRWFSECLS PPGGSDNLWN LVAVIKGQDD SLLPQNYCKG 790 800 810 820 830 840 IMHLKHLIKF RTSEAQELTT VKMSKFGGGI GVPAKEERLK EAAEIHLRLG QIQRYCELMV 850 860 870 880 890 900 ELGEWDKALS IAPGVSVKYW KKLMQRRADQ LIQEDKDDVI PYCIAIGDVK KLVHFFMSRG 910 920 930 940 950 960 QLKEALLVAQ AACEGNMQPL HVSVPKGASY SDDIYKEDFN ELLHKVSKEL AEWYFQDGRA 970 980 990 1000 1010 1020 VLAACCHLAI DNIELAMAYL IRGNELELAV CVGTVLGESA APATHYALEL LARKCMMISV 1030 1040 1050 1060 1070 1080 CFPCVGYSVP FCYVNRNLAA DLLLMIPDNE LHLIKLCAFY PGCTEEINDL HDKCKLPTVE 1090 1100 1110 1120 1130 1140 ECMQLAETAR ADDNIFETVK YYLLSQEPEK ALPIGISFVK EYISSSDWTL DTIYPVLDLL 1150 1160 1170 1180 1190 1200 SYIRTEKLLL HTCTEARNEL LILCGYIGAL LAIRRQYQSI VPALYEYTSQ LLKRREVSVP 1210 1220 1230 1240 1250 1260 LKIEYLSEEL DAWRACTQST NRSLEDSPYT PPSDSQRMIY ATLLKRLKEE SLKGIIGPDY 1270 1280 1290 1300 1310 1320 VTGSNLPSHS DIHISCLTGL KIQGPVFFLE DGKSAISLND ALMWAKVNPF SPLGTGIRLN PF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of WDR17, a novel WD repeat-containing gene on chromosome 4q34." Stohr H., Mohr N., Frohlich S., Mehdi S.Q., Bhattacharya S.S., Weber B.H.F. Biochim. Biophys. Acta 1579:18-25(2002) [PubMed: 12401215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-1295. Tissue: Retina.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF492460 mRNA. Translation: AAN64030.1. AC093605 Genomic DNA. No translation available.
IPI	IPI00218077.
RefSeq	NP_733828.2. NM_170710.4.
UniGene	Hs.532056. Hs.693278.
3D structure databases
ProteinModelPortal	Q8IZU2.
SMR	Q8IZU2. Positions 72-159, 225-261, 389-685.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZU2. 1 interaction.
PTM databases
PhosphoSite	Q8IZU2.
Polymorphism databases
DMDM	215273912.
Proteomic databases
PRIDE	Q8IZU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000280190; ENSP00000280190; ENSG00000150627.
GeneID	116966.
KEGG	hsa:116966.
UCSC	uc003iuj.1. human.
Organism-specific databases
CTD	116966.
GeneCards	GC04P176987.
H-InvDB	HIX0004647.
HGNC	HGNC:16661. WDR17.
HPA	HPA042766.
MIM	609005. gene.
neXtProt	NX_Q8IZU2.
PharmGKB	PA38181.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074625.
HOGENOM	HBG357400.
HOVERGEN	HBG070328.
InParanoid	Q8IZU2.
OMA	LYEYTSQ.
PhylomeDB	Q8IZU2.
Gene expression databases
ArrayExpress	Q8IZU2.
Bgee	Q8IZU2.
CleanEx	HS_WDR17.
Genevestigator	Q8IZU2.
GermOnline	ENSG00000150627. Homo sapiens.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 3 hits.
Pfam	PF00400. WD40. 8 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 11 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 2 hits.
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 5 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	80040.
SOURCE	Search...

Entry information

Entry name

WDR17_HUMAN

Accession

Primary (citable) accession number: Q8IZU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.