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Protein

WD repeat-containing protein 17

Gene

WDR17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Enzyme and pathway databases

SignaLinkiQ8IZU2

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 17
Gene namesi
Name:WDR17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000150627.15
HGNCiHGNC:16661 WDR17
MIMi609005 gene
neXtProtiNX_Q8IZU2

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi116966
OpenTargetsiENSG00000150627
PharmGKBiPA38181

Polymorphism and mutation databases

BioMutaiWDR17
DMDMi215273912

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513641 – 1322WD repeat-containing protein 17Add BLAST1322

Proteomic databases

EPDiQ8IZU2
MaxQBiQ8IZU2
PaxDbiQ8IZU2
PeptideAtlasiQ8IZU2
PRIDEiQ8IZU2

PTM databases

iPTMnetiQ8IZU2
PhosphoSitePlusiQ8IZU2

Expressioni

Gene expression databases

BgeeiENSG00000150627
CleanExiHS_WDR17
ExpressionAtlasiQ8IZU2 baseline and differential
GenevisibleiQ8IZU2 HS

Organism-specific databases

HPAiHPA042766

Interactioni

Protein-protein interaction databases

BioGridi1255441 interactor.
IntActiQ8IZU2 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8IZU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati81 – 121WD 1Add BLAST41
Repeati123 – 164WD 2Add BLAST42
Repeati171 – 211WD 3Add BLAST41
Repeati221 – 261WD 4Add BLAST41
Repeati266 – 307WD 5Add BLAST42
Repeati391 – 431WD 6Add BLAST41
Repeati434 – 474WD 7Add BLAST41
Repeati478 – 518WD 8Add BLAST41
Repeati519 – 559WD 9Add BLAST41
Repeati564 – 604WD 10Add BLAST41
Repeati607 – 647WD 11Add BLAST41
Repeati650 – 690WD 12Add BLAST41

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQU0 Eukaryota
ENOG410Z2VH LUCA
GeneTreeiENSGT00890000139430
HOGENOMiHOG000067976
HOVERGENiHBG070328
InParanoidiQ8IZU2
OMAiWNTEIPY
OrthoDBiEOG091G00LG
PhylomeDBiQ8IZU2
TreeFamiTF323190

Family and domain databases

Gene3Di2.130.10.104 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR020472 G-protein_beta_WD-40_rep
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWMTYISNW FEQDDWYEGL QRANMSQVRQ VGLLAAGCQP WNKDVCAASG
60 70 80 90 100
DRFAYCATLA IYIYQLDHRY NEFKLHAIMS EHKKTITAIS WCPHNPDLFA
110 120 130 140 150
SGSTDNLVII WNVAEQKVIA KLDSTKGIPA SLSWCWNAED VVAFVSHRGP
160 170 180 190 200
LFIWTISGPD SGVIVHKDAH SFLSDICMFR WHTHQKGKVV FGHIDGSLSI
210 220 230 240 250
FHPGNKNQKH VLRPESLEGT DEEDPVTALE WDPLSTDYLL VVNLHYGIRL
260 270 280 290 300
VDSESLSCIT TFNLPSAAAS VQCLAWVPSA PGMFITGDSQ VGVLRIWNVS
310 320 330 340 350
RTTPIDNLKL KKTGFHCLHV LNSPPRKKFS VQSPTKNHYT SSTSEAVPPP
360 370 380 390 400
TLTQNQAFSL PPGHAVCCFL DGGVGLYDMG AKKWDFLRDL GHVETIFDCK
410 420 430 440 450
FKPDDPNLLA TASFDGTIKV WDINTLTAVY TSPGNEGVIY SLSWAPGGLN
460 470 480 490 500
CIAGGTSRNG AFIWNVQKGK IIQRFNEHGT NGIFCIAWSH KDSKRIATCS
510 520 530 540 550
SDGFCIIRTI DGKVLHKYKH PAAVFGCDWS QNNKDMIATG CEDTNVRVYY
560 570 580 590 600
VATSSDQPLK VFSGHTAKVF HVKWSPLREG ILCSGSDDGT VRIWDYTQDA
610 620 630 640 650
CINILNGHTA PVRGLMWNTE IPYLLISGSW DYTIKVWDTR EGTCVDTVYD
660 670 680 690 700
HGADVYGLTC HPSRPFTMAS CSRDSTVRLW SLTALVTPVQ INILADRSWE
710 720 730 740 750
EIIGNTDYAI EPGTPPLLCG KVSRDIRQEI EKLTANSQVK KLRWFSECLS
760 770 780 790 800
PPGGSDNLWN LVAVIKGQDD SLLPQNYCKG IMHLKHLIKF RTSEAQELTT
810 820 830 840 850
VKMSKFGGGI GVPAKEERLK EAAEIHLRLG QIQRYCELMV ELGEWDKALS
860 870 880 890 900
IAPGVSVKYW KKLMQRRADQ LIQEDKDDVI PYCIAIGDVK KLVHFFMSRG
910 920 930 940 950
QLKEALLVAQ AACEGNMQPL HVSVPKGASY SDDIYKEDFN ELLHKVSKEL
960 970 980 990 1000
AEWYFQDGRA VLAACCHLAI DNIELAMAYL IRGNELELAV CVGTVLGESA
1010 1020 1030 1040 1050
APATHYALEL LARKCMMISV CFPCVGYSVP FCYVNRNLAA DLLLMIPDNE
1060 1070 1080 1090 1100
LHLIKLCAFY PGCTEEINDL HDKCKLPTVE ECMQLAETAR ADDNIFETVK
1110 1120 1130 1140 1150
YYLLSQEPEK ALPIGISFVK EYISSSDWTL DTIYPVLDLL SYIRTEKLLL
1160 1170 1180 1190 1200
HTCTEARNEL LILCGYIGAL LAIRRQYQSI VPALYEYTSQ LLKRREVSVP
1210 1220 1230 1240 1250
LKIEYLSEEL DAWRACTQST NRSLEDSPYT PPSDSQRMIY ATLLKRLKEE
1260 1270 1280 1290 1300
SLKGIIGPDY VTGSNLPSHS DIHISCLTGL KIQGPVFFLE DGKSAISLND
1310 1320
ALMWAKVNPF SPLGTGIRLN PF
Length:1,322
Mass (Da):147,703
Last modified:November 25, 2008 - v2
Checksum:i99FFCE51B9EA8175
GO
Isoform 2 (identifier: Q8IZU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     1021-1036: CFPCVGYSVPFCYVNR → W

Note: No experimental confirmation available.
Show »
Length:1,283
Mass (Da):143,016
Checksum:i805643CB01B5A6B8
GO

Sequence cautioni

The sequence BC146812 differs from that shown. Reason: Frameshift at position 268.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213R → S in BC146812 (PubMed:15489334).Curated1
Sequence conflicti783H → Q in BC146812 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062101418I → V. Corresponds to variant dbSNP:rs59567138Ensembl.1
Natural variantiVAR_047399814A → T1 PublicationCorresponds to variant dbSNP:rs4690661Ensembl.1
Natural variantiVAR_047400913C → S1 PublicationCorresponds to variant dbSNP:rs7693453Ensembl.1
Natural variantiVAR_047401952E → K. Corresponds to variant dbSNP:rs6810394Ensembl.1
Natural variantiVAR_0474021215A → T1 PublicationCorresponds to variant dbSNP:rs17625943Ensembl.1
Natural variantiVAR_0474031295A → T1 PublicationCorresponds to variant dbSNP:rs11736872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0472011 – 24Missing in isoform 2. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_0472021021 – 1036CFPCV…CYVNR → W in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492460 mRNA Translation: AAN64030.1
AC093605 Genomic DNA No translation available.
BC146812 mRNA No translation available.
DQ426895 mRNA Translation: ABD90546.1
DQ426896 mRNA Translation: ABD90547.1
CCDSiCCDS3825.1 [Q8IZU2-1]
CCDS43284.2 [Q8IZU2-2]
RefSeqiNP_733828.2, NM_170710.4 [Q8IZU2-1]
NP_851782.3, NM_181265.3 [Q8IZU2-2]
UniGeneiHs.532056
Hs.693278

Genome annotation databases

EnsembliENST00000280190; ENSP00000280190; ENSG00000150627 [Q8IZU2-1]
ENST00000508596; ENSP00000422763; ENSG00000150627 [Q8IZU2-2]
GeneIDi116966
KEGGihsa:116966
UCSCiuc003iuj.4 human [Q8IZU2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWDR17_HUMAN
AccessioniPrimary (citable) accession number: Q8IZU2
Secondary accession number(s): E7EQX0, Q0QD35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome