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Protein

C-type lectin-like domain family 1

Gene

CLECL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin-like domain family 1
Alternative name(s):
Dendritic cell-associated lectin 1
Short name:
DC-associated lectin-1
Short name:
DCAL-1
Gene namesi
Name:CLECL1
Synonyms:DCAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24462. CLECL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767CytoplasmicSequence analysisAdd
BLAST
Transmembranei68 – 8821Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini89 – 16779ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382341.

Polymorphism and mutation databases

BioMutaiCLECL1.
DMDMi74728443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167C-type lectin-like domain family 1PRO_0000317461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence analysis
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZS7.
PRIDEiQ8IZS7.

PTM databases

iPTMnetiQ8IZS7.
PhosphoSiteiQ8IZS7.

Expressioni

Tissue specificityi

Expressed in spleen, lymph node, and tonsil. Lower expression in peripheral blood, bone marrow, and colon. No expression detected in thymus. Highly expressed in dendritic and B-cells.1 Publication

Gene expression databases

BgeeiENSG00000184293.
CleanExiHS_CLECL1.
ExpressionAtlasiQ8IZS7. baseline and differential.
GenevisibleiQ8IZS7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331766.

Structurei

3D structure databases

ProteinModelPortaliQ8IZS7.
SMRiQ8IZS7. Positions 117-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 16752C-type lectin; atypicalAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00840000130358.
HOGENOMiHOG000111786.
InParanoidiQ8IZS7.
KOiK17518.
PhylomeDBiQ8IZS7.
TreeFamiTF342285.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IZS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSNFFHVIQ VFEKSATLIS KTEHIGFVIY SWRKSTTHLG SRRKFAISIY
60 70 80 90 100
LSEVSLQKYD CPFSGTSFVV FSLFLICAMA GDVVYADIKT VRTSPLELAF
110 120 130 140 150
PLQRSVSFNF STVHKSCPAK DWKVHKGKCY WIAETKKSWN KSQNDCAINN
160
SYLMVIQDIT AMVRFNI
Length:167
Mass (Da):19,115
Last modified:March 1, 2003 - v1
Checksum:i581A6F08DB32A53C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518873 mRNA. Translation: AAN64752.1.
BC093857 mRNA. Translation: AAH93857.1.
BC093859 mRNA. Translation: AAH93859.1.
CCDSiCCDS8603.1.
RefSeqiNP_001240679.1. NM_001253750.1.
NP_001254630.1. NM_001267701.1.
NP_742001.1. NM_172004.3.
UniGeneiHs.560087.
Hs.734740.

Genome annotation databases

EnsembliENST00000327839; ENSP00000331766; ENSG00000184293.
GeneIDi160365.
KEGGihsa:160365.
UCSCiuc001qwj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518873 mRNA. Translation: AAN64752.1.
BC093857 mRNA. Translation: AAH93857.1.
BC093859 mRNA. Translation: AAH93859.1.
CCDSiCCDS8603.1.
RefSeqiNP_001240679.1. NM_001253750.1.
NP_001254630.1. NM_001267701.1.
NP_742001.1. NM_172004.3.
UniGeneiHs.560087.
Hs.734740.

3D structure databases

ProteinModelPortaliQ8IZS7.
SMRiQ8IZS7. Positions 117-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331766.

PTM databases

iPTMnetiQ8IZS7.
PhosphoSiteiQ8IZS7.

Polymorphism and mutation databases

BioMutaiCLECL1.
DMDMi74728443.

Proteomic databases

PaxDbiQ8IZS7.
PRIDEiQ8IZS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327839; ENSP00000331766; ENSG00000184293.
GeneIDi160365.
KEGGihsa:160365.
UCSCiuc001qwj.4. human.

Organism-specific databases

CTDi160365.
GeneCardsiCLECL1.
HGNCiHGNC:24462. CLECL1.
MIMi607467. gene.
neXtProtiNX_Q8IZS7.
PharmGKBiPA162382341.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00840000130358.
HOGENOMiHOG000111786.
InParanoidiQ8IZS7.
KOiK17518.
PhylomeDBiQ8IZS7.
TreeFamiTF342285.

Miscellaneous databases

GenomeRNAii160365.
PROiQ8IZS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184293.
CleanExiHS_CLECL1.
ExpressionAtlasiQ8IZS7. baseline and differential.
GenevisibleiQ8IZS7. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCLCL1_HUMAN
AccessioniPrimary (citable) accession number: Q8IZS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.