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Q8IZR5

- CKLF4_HUMAN

UniProt

Q8IZR5 - CKLF4_HUMAN

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Protein
CKLF-like MARVEL transmembrane domain-containing protein 4
Gene
CMTM4, CKLFSF4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 4
Alternative name(s):
Chemokine-like factor superfamily member 4
Gene namesi
Name:CMTM4
Synonyms:CKLFSF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:19175. CMTM4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Transmembranei123 – 14321Helical; Reviewed prediction
Add
BLAST
Transmembranei151 – 17121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234CKLF-like MARVEL transmembrane domain-containing protein 4
PRO_0000186103Add
BLAST

Proteomic databases

MaxQBiQ8IZR5.
PaxDbiQ8IZR5.
PRIDEiQ8IZR5.

PTM databases

PhosphoSiteiQ8IZR5.

Expressioni

Tissue specificityi

Highly expressed in testis and prostate.1 Publication

Gene expression databases

ArrayExpressiQ8IZR5.
BgeeiQ8IZR5.
CleanExiHS_CMTM4.
GenevestigatoriQ8IZR5.

Organism-specific databases

HPAiHPA014704.
HPA023890.

Interactioni

Protein-protein interaction databases

BioGridi126972. 2 interactions.
IntActiQ8IZR5. 2 interactions.
STRINGi9606.ENSP00000333833.

Structurei

3D structure databases

ProteinModelPortaliQ8IZR5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 176128MARVEL
Add
BLAST

Sequence similaritiesi

Contains 1 MARVEL domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320824.
HOGENOMiHOG000261609.
HOVERGENiHBG050980.
InParanoidiQ8IZR5.
OMAiAVQKWRV.
OrthoDBiEOG7FNC8Q.
PhylomeDBiQ8IZR5.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZR5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL    50
RGALGRLKVA QVILALIAFI CIETIMACSP CEGLYFFEFV SCSAFVVTGV 100
LLIMFSLNLH MRIPQINWNL TDLVNTGLSA FLFFIASIVL AALNHRAGAE 150
IAAVIFGFLA TAAYAVNTFL AVQKWRVSVR QQSTNDYIRA RTESRDVDSR 200
PEIQRLDTFS YSTNVTVRKK SPTNLLSLNH WQLA 234
Length:234
Mass (Da):25,828
Last modified:March 1, 2003 - v1
Checksum:i629B5CCEE873C895
GO
Isoform 2 (identifier: Q8IZR5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-234: Missing.

Show »
Length:208
Mass (Da):22,840
Checksum:iEF8B0E6B5D8590A4
GO
Isoform 3 (identifier: Q8IZR5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-62: Missing.
     209-234: Missing.

Show »
Length:179
Mass (Da):19,690
Checksum:i26A798C438B1C196
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei34 – 6229Missing in isoform 3.
VSP_008260Add
BLAST
Alternative sequencei209 – 23426Missing in isoform 2 and isoform 3.
VSP_008261Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF521889 mRNA. Translation: AAN73845.1.
AF521890 mRNA. Translation: AAN73846.1.
AF479814 mRNA. Translation: AAN73436.1.
BC093679 mRNA. Translation: AAH93679.1.
CCDSiCCDS10817.1. [Q8IZR5-1]
CCDS42170.1. [Q8IZR5-2]
RefSeqiNP_848933.1. NM_178818.2. [Q8IZR5-1]
NP_852662.1. NM_181521.2. [Q8IZR5-2]
UniGeneiHs.643961.

Genome annotation databases

EnsembliENST00000330687; ENSP00000333833; ENSG00000183723. [Q8IZR5-1]
ENST00000394106; ENSP00000377666; ENSG00000183723. [Q8IZR5-2]
ENST00000563952; ENSP00000456380; ENSG00000183723. [Q8IZR5-3]
GeneIDi146223.
KEGGihsa:146223.
UCSCiuc002epz.3. human. [Q8IZR5-1]

Polymorphism databases

DMDMi34921813.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF521889 mRNA. Translation: AAN73845.1 .
AF521890 mRNA. Translation: AAN73846.1 .
AF479814 mRNA. Translation: AAN73436.1 .
BC093679 mRNA. Translation: AAH93679.1 .
CCDSi CCDS10817.1. [Q8IZR5-1 ]
CCDS42170.1. [Q8IZR5-2 ]
RefSeqi NP_848933.1. NM_178818.2. [Q8IZR5-1 ]
NP_852662.1. NM_181521.2. [Q8IZR5-2 ]
UniGenei Hs.643961.

3D structure databases

ProteinModelPortali Q8IZR5.
ModBasei Search...

Protein-protein interaction databases

BioGridi 126972. 2 interactions.
IntActi Q8IZR5. 2 interactions.
STRINGi 9606.ENSP00000333833.

PTM databases

PhosphoSitei Q8IZR5.

Polymorphism databases

DMDMi 34921813.

Proteomic databases

MaxQBi Q8IZR5.
PaxDbi Q8IZR5.
PRIDEi Q8IZR5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330687 ; ENSP00000333833 ; ENSG00000183723 . [Q8IZR5-1 ]
ENST00000394106 ; ENSP00000377666 ; ENSG00000183723 . [Q8IZR5-2 ]
ENST00000563952 ; ENSP00000456380 ; ENSG00000183723 . [Q8IZR5-3 ]
GeneIDi 146223.
KEGGi hsa:146223.
UCSCi uc002epz.3. human. [Q8IZR5-1 ]

Organism-specific databases

CTDi 146223.
GeneCardsi GC16M066648.
HGNCi HGNC:19175. CMTM4.
HPAi HPA014704.
HPA023890.
MIMi 607887. gene.
neXtProti NX_Q8IZR5.
PharmGKBi PA38814.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320824.
HOGENOMi HOG000261609.
HOVERGENi HBG050980.
InParanoidi Q8IZR5.
OMAi AVQKWRV.
OrthoDBi EOG7FNC8Q.
PhylomeDBi Q8IZR5.
TreeFami TF317387.

Miscellaneous databases

ChiTaRSi CMTM4. human.
GenomeRNAii 146223.
NextBioi 85306.
PROi Q8IZR5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IZR5.
Bgeei Q8IZR5.
CleanExi HS_CMTM4.
Genevestigatori Q8IZR5.

Family and domain databases

InterProi IPR008253. Marvel.
[Graphical view ]
Pfami PF01284. MARVEL. 1 hit.
[Graphical view ]
PROSITEi PS51225. MARVEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Ding P., Han W., Shi S., Yang T., Song Q., Zhang Y., Ma D.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Tissue: Kidney.
  2. "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
    Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
    Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCKLF4_HUMAN
AccessioniPrimary (citable) accession number: Q8IZR5
Secondary accession number(s): Q52M40, Q8IZR4, Q8IZV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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