Q8IZR5 (CKLF4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 4

Alternative name(s):
Chemokine-like factor superfamily member 4

Gene names

Name:	CMTM4
Synonyms:	CKLFSF4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in testis and prostate. Ref.2
Sequence similarities	Belongs to the chemokine-like factor family. Contains 1 MARVEL domain.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Cytokine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZR5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZR5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     209-234: Missing.

Isoform 3 (identifier: Q8IZR5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     34-62: Missing.
     209-234: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	CKLF-like MARVEL transmembrane domain-containing protein 4		PRO_0000186103
Regions
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	123 – 143	21	Helical; Potential
	Transmembrane	151 – 171	21	Helical; Potential
	Domain	49 – 176	128	MARVEL
Natural variations
	Alternative sequence	34 – 62	29	Missing in isoform 3.		VSP_008260
	Alternative sequence	209 – 234	26	Missing in isoform 2 and isoform 3.		VSP_008261

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 629B5CCEE873C895	FASTA	234	25,828
	10 20 30 40 50 60 MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL RGALGRLKVA 70 80 90 100 110 120 QVILALIAFI CIETIMACSP CEGLYFFEFV SCSAFVVTGV LLIMFSLNLH MRIPQINWNL 130 140 150 160 170 180 TDLVNTGLSA FLFFIASIVL AALNHRAGAE IAAVIFGFLA TAAYAVNTFL AVQKWRVSVR 190 200 210 220 230 QQSTNDYIRA RTESRDVDSR PEIQRLDTFS YSTNVTVRKK SPTNLLSLNH WQLA
	Isoform 2 [UniParc]. Checksum: EF8B0E6B5D8590A4	FASTA	208	22,840
	10 20 30 40 50 60 MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL RGALGRLKVA 70 80 90 100 110 120 QVILALIAFI CIETIMACSP CEGLYFFEFV SCSAFVVTGV LLIMFSLNLH MRIPQINWNL 130 140 150 160 170 180 TDLVNTGLSA FLFFIASIVL AALNHRAGAE IAAVIFGFLA TAAYAVNTFL AVQKWRVSVR 190 200 QQSTNDYIRA RTESRDVDSR PEIQRLDT
	Isoform 3 [UniParc]. Checksum: 26A798C438B1C196	FASTA	179	19,690
	10 20 30 40 50 60 MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPILALIAF ICIETIMACS PCEGLYFFEF 70 80 90 100 110 120 VSCSAFVVTG VLLIMFSLNL HMRIPQINWN LTDLVNTGLS AFLFFIASIV LAALNHRAGA 130 140 150 160 170 EIAAVIFGFL ATAAYAVNTF LAVQKWRVSV RQQSTNDYIR ARTESRDVDS RPEIQRLDT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ding P., Han W., Shi S., Yang T., Song Q., Zhang Y., Ma D. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). Tissue: Kidney.
[2]	"Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation." Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D. Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Spleen.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Liver.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF521889 mRNA. Translation: AAN73845.1. AF521890 mRNA. Translation: AAN73846.1. AF479814 mRNA. Translation: AAN73436.1. BC093679 mRNA. Translation: AAH93679.1.
IPI	IPI00293848. IPI00328313. IPI00333212.
RefSeq	NP_848933.1. NM_178818.2. NP_852662.1. NM_181521.2.
UniGene	Hs.643961.
3D structure databases
ProteinModelPortal	Q8IZR5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZR5. 2 interactions.
STRING	9606.ENSP00000333833.
PTM databases
PhosphoSite	Q8IZR5.
Polymorphism databases
DMDM	34921813.
Proteomic databases
PaxDb	Q8IZR5.
PRIDE	Q8IZR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330687; ENSP00000333833; ENSG00000183723. ENST00000394106; ENSP00000377666; ENSG00000183723. ENST00000563952; ENSP00000456380; ENSG00000183723.
GeneID	146223.
KEGG	hsa:146223.
UCSC	uc002epz.3. human.
Organism-specific databases
CTD	146223.
GeneCards	GC16M066648.
HGNC	HGNC:19175. CMTM4.
HPA	HPA014704. HPA023890.
MIM	607887. gene.
neXtProt	NX_Q8IZR5.
PharmGKB	PA38814.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG320824.
HOGENOM	HOG000261609.
HOVERGEN	HBG050980.
InParanoid	Q8IZR5.
OMA	AVQKWRV.
OrthoDB	EOG4NVZMC.
PhylomeDB	Q8IZR5.
Gene expression databases
Bgee	Q8IZR5.
CleanEx	HS_CMTM4.
Genevestigator	Q8IZR5.
GermOnline	ENSG00000183723. Homo sapiens.
Family and domain databases
InterPro	IPR008253. Marvel. IPR021128. MARVEL-like_dom. [Graphical view]
Pfam	PF01284. MARVEL. 1 hit. [Graphical view]
PROSITE	PS51225. MARVEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CMTM4. human.
GenomeRNAi	146223.
NextBio	85306.
SOURCE	Search...

Entry information

Entry name

CKLF4_HUMAN

Accession

Primary (citable) accession number: Q8IZR5
Secondary accession number(s): Q52M40, Q8IZR4, Q8IZV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.