Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8IZR5 (CKLF4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CKLF-like MARVEL transmembrane domain-containing protein 4
Alternative name(s):
Chemokine-like factor superfamily member 4
Gene names
Name:CMTM4
Synonyms:CKLFSF4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in testis and prostate. Ref.2

Sequence similarities

Belongs to the chemokine-like factor family.

Contains 1 MARVEL domain.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionCytokine
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IZR5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IZR5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     209-234: Missing.
Isoform 3 (identifier: Q8IZR5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     34-62: Missing.
     209-234: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234CKLF-like MARVEL transmembrane domain-containing protein 4
PRO_0000186103

Regions

Transmembrane59 – 7921Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane151 – 17121Helical; Potential
Domain49 – 176128MARVEL

Natural variations

Alternative sequence34 – 6229Missing in isoform 3.
VSP_008260
Alternative sequence209 – 23426Missing in isoform 2 and isoform 3.
VSP_008261

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 629B5CCEE873C895

FASTA23425,828
        10         20         30         40         50         60 
MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL RGALGRLKVA 

        70         80         90        100        110        120 
QVILALIAFI CIETIMACSP CEGLYFFEFV SCSAFVVTGV LLIMFSLNLH MRIPQINWNL 

       130        140        150        160        170        180 
TDLVNTGLSA FLFFIASIVL AALNHRAGAE IAAVIFGFLA TAAYAVNTFL AVQKWRVSVR 

       190        200        210        220        230 
QQSTNDYIRA RTESRDVDSR PEIQRLDTFS YSTNVTVRKK SPTNLLSLNH WQLA 

« Hide

Isoform 2 [UniParc].

Checksum: EF8B0E6B5D8590A4
Show »

FASTA20822,840
Isoform 3 [UniParc].

Checksum: 26A798C438B1C196
Show »

FASTA17919,690

References

« Hide 'large scale' references
[1]Ding P., Han W., Shi S., Yang T., Song Q., Zhang Y., Ma D.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
Tissue: Kidney.
[2]"Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Spleen.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Liver.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF521889 mRNA. Translation: AAN73845.1.
AF521890 mRNA. Translation: AAN73846.1.
AF479814 mRNA. Translation: AAN73436.1.
BC093679 mRNA. Translation: AAH93679.1.
RefSeqNP_848933.1. NM_178818.2.
NP_852662.1. NM_181521.2.
UniGeneHs.643961.

3D structure databases

ProteinModelPortalQ8IZR5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126972. 2 interactions.
IntActQ8IZR5. 2 interactions.
STRING9606.ENSP00000333833.

PTM databases

PhosphoSiteQ8IZR5.

Polymorphism databases

DMDM34921813.

Proteomic databases

PaxDbQ8IZR5.
PRIDEQ8IZR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330687; ENSP00000333833; ENSG00000183723. [Q8IZR5-1]
ENST00000394106; ENSP00000377666; ENSG00000183723. [Q8IZR5-2]
ENST00000563952; ENSP00000456380; ENSG00000183723. [Q8IZR5-3]
GeneID146223.
KEGGhsa:146223.
UCSCuc002epz.3. human. [Q8IZR5-1]

Organism-specific databases

CTD146223.
GeneCardsGC16M066648.
HGNCHGNC:19175. CMTM4.
HPAHPA014704.
HPA023890.
MIM607887. gene.
neXtProtNX_Q8IZR5.
PharmGKBPA38814.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320824.
HOGENOMHOG000261609.
HOVERGENHBG050980.
InParanoidQ8IZR5.
OMAAVQKWRV.
OrthoDBEOG7FNC8Q.
PhylomeDBQ8IZR5.
TreeFamTF317387.

Gene expression databases

ArrayExpressQ8IZR5.
BgeeQ8IZR5.
CleanExHS_CMTM4.
GenevestigatorQ8IZR5.

Family and domain databases

InterProIPR008253. Marvel.
[Graphical view]
PfamPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCMTM4. human.
GenomeRNAi146223.
NextBio85306.
PROQ8IZR5.
SOURCESearch...

Entry information

Entry nameCKLF4_HUMAN
AccessionPrimary (citable) accession number: Q8IZR5
Secondary accession number(s): Q52M40, Q8IZR4, Q8IZV1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM