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Q8IZR5

- CKLF4_HUMAN

UniProt

Q8IZR5 - CKLF4_HUMAN

Protein

CKLF-like MARVEL transmembrane domain-containing protein 4

Gene

CMTM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 4
    Alternative name(s):
    Chemokine-like factor superfamily member 4
    Gene namesi
    Name:CMTM4
    Synonyms:CKLFSF4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:19175. CMTM4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38814.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234CKLF-like MARVEL transmembrane domain-containing protein 4PRO_0000186103Add
    BLAST

    Proteomic databases

    MaxQBiQ8IZR5.
    PaxDbiQ8IZR5.
    PRIDEiQ8IZR5.

    PTM databases

    PhosphoSiteiQ8IZR5.

    Expressioni

    Tissue specificityi

    Highly expressed in testis and prostate.1 Publication

    Gene expression databases

    ArrayExpressiQ8IZR5.
    BgeeiQ8IZR5.
    CleanExiHS_CMTM4.
    GenevestigatoriQ8IZR5.

    Organism-specific databases

    HPAiHPA014704.
    HPA023890.

    Interactioni

    Protein-protein interaction databases

    BioGridi126972. 2 interactions.
    IntActiQ8IZR5. 2 interactions.
    STRINGi9606.ENSP00000333833.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 176128MARVELPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the chemokine-like factor family.Curated
    Contains 1 MARVEL domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320824.
    HOGENOMiHOG000261609.
    HOVERGENiHBG050980.
    InParanoidiQ8IZR5.
    OMAiAVQKWRV.
    OrthoDBiEOG7FNC8Q.
    PhylomeDBiQ8IZR5.
    TreeFamiTF317387.

    Family and domain databases

    InterProiIPR008253. Marvel.
    [Graphical view]
    PfamiPF01284. MARVEL. 1 hit.
    [Graphical view]
    PROSITEiPS51225. MARVEL. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IZR5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL    50
    RGALGRLKVA QVILALIAFI CIETIMACSP CEGLYFFEFV SCSAFVVTGV 100
    LLIMFSLNLH MRIPQINWNL TDLVNTGLSA FLFFIASIVL AALNHRAGAE 150
    IAAVIFGFLA TAAYAVNTFL AVQKWRVSVR QQSTNDYIRA RTESRDVDSR 200
    PEIQRLDTFS YSTNVTVRKK SPTNLLSLNH WQLA 234
    Length:234
    Mass (Da):25,828
    Last modified:March 1, 2003 - v1
    Checksum:i629B5CCEE873C895
    GO
    Isoform 2 (identifier: Q8IZR5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         209-234: Missing.

    Show »
    Length:208
    Mass (Da):22,840
    Checksum:iEF8B0E6B5D8590A4
    GO
    Isoform 3 (identifier: Q8IZR5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         34-62: Missing.
         209-234: Missing.

    Show »
    Length:179
    Mass (Da):19,690
    Checksum:i26A798C438B1C196
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei34 – 6229Missing in isoform 3. 1 PublicationVSP_008260Add
    BLAST
    Alternative sequencei209 – 23426Missing in isoform 2 and isoform 3. 3 PublicationsVSP_008261Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF521889 mRNA. Translation: AAN73845.1.
    AF521890 mRNA. Translation: AAN73846.1.
    AF479814 mRNA. Translation: AAN73436.1.
    BC093679 mRNA. Translation: AAH93679.1.
    CCDSiCCDS10817.1. [Q8IZR5-1]
    CCDS42170.1. [Q8IZR5-2]
    RefSeqiNP_848933.1. NM_178818.2. [Q8IZR5-1]
    NP_852662.1. NM_181521.2. [Q8IZR5-2]
    UniGeneiHs.643961.

    Genome annotation databases

    EnsembliENST00000330687; ENSP00000333833; ENSG00000183723. [Q8IZR5-1]
    ENST00000394106; ENSP00000377666; ENSG00000183723. [Q8IZR5-2]
    ENST00000563952; ENSP00000456380; ENSG00000183723. [Q8IZR5-3]
    GeneIDi146223.
    KEGGihsa:146223.
    UCSCiuc002epz.3. human. [Q8IZR5-1]

    Polymorphism databases

    DMDMi34921813.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF521889 mRNA. Translation: AAN73845.1 .
    AF521890 mRNA. Translation: AAN73846.1 .
    AF479814 mRNA. Translation: AAN73436.1 .
    BC093679 mRNA. Translation: AAH93679.1 .
    CCDSi CCDS10817.1. [Q8IZR5-1 ]
    CCDS42170.1. [Q8IZR5-2 ]
    RefSeqi NP_848933.1. NM_178818.2. [Q8IZR5-1 ]
    NP_852662.1. NM_181521.2. [Q8IZR5-2 ]
    UniGenei Hs.643961.

    3D structure databases

    ProteinModelPortali Q8IZR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126972. 2 interactions.
    IntActi Q8IZR5. 2 interactions.
    STRINGi 9606.ENSP00000333833.

    PTM databases

    PhosphoSitei Q8IZR5.

    Polymorphism databases

    DMDMi 34921813.

    Proteomic databases

    MaxQBi Q8IZR5.
    PaxDbi Q8IZR5.
    PRIDEi Q8IZR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330687 ; ENSP00000333833 ; ENSG00000183723 . [Q8IZR5-1 ]
    ENST00000394106 ; ENSP00000377666 ; ENSG00000183723 . [Q8IZR5-2 ]
    ENST00000563952 ; ENSP00000456380 ; ENSG00000183723 . [Q8IZR5-3 ]
    GeneIDi 146223.
    KEGGi hsa:146223.
    UCSCi uc002epz.3. human. [Q8IZR5-1 ]

    Organism-specific databases

    CTDi 146223.
    GeneCardsi GC16M066648.
    HGNCi HGNC:19175. CMTM4.
    HPAi HPA014704.
    HPA023890.
    MIMi 607887. gene.
    neXtProti NX_Q8IZR5.
    PharmGKBi PA38814.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320824.
    HOGENOMi HOG000261609.
    HOVERGENi HBG050980.
    InParanoidi Q8IZR5.
    OMAi AVQKWRV.
    OrthoDBi EOG7FNC8Q.
    PhylomeDBi Q8IZR5.
    TreeFami TF317387.

    Miscellaneous databases

    ChiTaRSi CMTM4. human.
    GenomeRNAii 146223.
    NextBioi 85306.
    PROi Q8IZR5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZR5.
    Bgeei Q8IZR5.
    CleanExi HS_CMTM4.
    Genevestigatori Q8IZR5.

    Family and domain databases

    InterProi IPR008253. Marvel.
    [Graphical view ]
    Pfami PF01284. MARVEL. 1 hit.
    [Graphical view ]
    PROSITEi PS51225. MARVEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ding P., Han W., Shi S., Yang T., Song Q., Zhang Y., Ma D.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
      Tissue: Kidney.
    2. "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
      Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
      Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Spleen.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCKLF4_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZR5
    Secondary accession number(s): Q52M40, Q8IZR4, Q8IZV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3