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Protein

CKLF-like MARVEL transmembrane domain-containing protein 4

Gene

CMTM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 4
Alternative name(s):
Chemokine-like factor superfamily member 4
Gene namesi
Name:CMTM4
Synonyms:CKLFSF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:19175. CMTM4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234CKLF-like MARVEL transmembrane domain-containing protein 4PRO_0000186103Add
BLAST

Proteomic databases

MaxQBiQ8IZR5.
PaxDbiQ8IZR5.
PRIDEiQ8IZR5.

PTM databases

PhosphoSiteiQ8IZR5.

Expressioni

Tissue specificityi

Highly expressed in testis and prostate.1 Publication

Gene expression databases

BgeeiQ8IZR5.
CleanExiHS_CMTM4.
ExpressionAtlasiQ8IZR5. baseline and differential.
GenevestigatoriQ8IZR5.

Organism-specific databases

HPAiHPA014704.
HPA023890.

Interactioni

Protein-protein interaction databases

BioGridi126972. 4 interactions.
IntActiQ8IZR5. 2 interactions.
STRINGi9606.ENSP00000333833.

Structurei

3D structure databases

ProteinModelPortaliQ8IZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 176128MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320824.
GeneTreeiENSGT00530000063578.
HOGENOMiHOG000261609.
HOVERGENiHBG050980.
InParanoidiQ8IZR5.
OMAiAVQKWRV.
OrthoDBiEOG7FNC8Q.
PhylomeDBiQ8IZR5.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL
60 70 80 90 100
RGALGRLKVA QVILALIAFI CIETIMACSP CEGLYFFEFV SCSAFVVTGV
110 120 130 140 150
LLIMFSLNLH MRIPQINWNL TDLVNTGLSA FLFFIASIVL AALNHRAGAE
160 170 180 190 200
IAAVIFGFLA TAAYAVNTFL AVQKWRVSVR QQSTNDYIRA RTESRDVDSR
210 220 230
PEIQRLDTFS YSTNVTVRKK SPTNLLSLNH WQLA
Length:234
Mass (Da):25,828
Last modified:March 1, 2003 - v1
Checksum:i629B5CCEE873C895
GO
Isoform 2 (identifier: Q8IZR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-234: Missing.

Show »
Length:208
Mass (Da):22,840
Checksum:iEF8B0E6B5D8590A4
GO
Isoform 3 (identifier: Q8IZR5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-62: Missing.
     209-234: Missing.

Show »
Length:179
Mass (Da):19,690
Checksum:i26A798C438B1C196
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei34 – 6229Missing in isoform 3. 1 PublicationVSP_008260Add
BLAST
Alternative sequencei209 – 23426Missing in isoform 2 and isoform 3. 3 PublicationsVSP_008261Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521889 mRNA. Translation: AAN73845.1.
AF521890 mRNA. Translation: AAN73846.1.
AF479814 mRNA. Translation: AAN73436.1.
BC093679 mRNA. Translation: AAH93679.1.
CCDSiCCDS10817.1. [Q8IZR5-1]
CCDS42170.1. [Q8IZR5-2]
RefSeqiNP_848933.1. NM_178818.2. [Q8IZR5-1]
NP_852662.1. NM_181521.2. [Q8IZR5-2]
UniGeneiHs.643961.

Genome annotation databases

EnsembliENST00000330687; ENSP00000333833; ENSG00000183723. [Q8IZR5-1]
ENST00000394106; ENSP00000377666; ENSG00000183723. [Q8IZR5-2]
ENST00000563952; ENSP00000456380; ENSG00000183723. [Q8IZR5-3]
GeneIDi146223.
KEGGihsa:146223.
UCSCiuc002epz.3. human. [Q8IZR5-1]

Polymorphism databases

DMDMi34921813.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521889 mRNA. Translation: AAN73845.1.
AF521890 mRNA. Translation: AAN73846.1.
AF479814 mRNA. Translation: AAN73436.1.
BC093679 mRNA. Translation: AAH93679.1.
CCDSiCCDS10817.1. [Q8IZR5-1]
CCDS42170.1. [Q8IZR5-2]
RefSeqiNP_848933.1. NM_178818.2. [Q8IZR5-1]
NP_852662.1. NM_181521.2. [Q8IZR5-2]
UniGeneiHs.643961.

3D structure databases

ProteinModelPortaliQ8IZR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126972. 4 interactions.
IntActiQ8IZR5. 2 interactions.
STRINGi9606.ENSP00000333833.

PTM databases

PhosphoSiteiQ8IZR5.

Polymorphism databases

DMDMi34921813.

Proteomic databases

MaxQBiQ8IZR5.
PaxDbiQ8IZR5.
PRIDEiQ8IZR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330687; ENSP00000333833; ENSG00000183723. [Q8IZR5-1]
ENST00000394106; ENSP00000377666; ENSG00000183723. [Q8IZR5-2]
ENST00000563952; ENSP00000456380; ENSG00000183723. [Q8IZR5-3]
GeneIDi146223.
KEGGihsa:146223.
UCSCiuc002epz.3. human. [Q8IZR5-1]

Organism-specific databases

CTDi146223.
GeneCardsiGC16M066648.
HGNCiHGNC:19175. CMTM4.
HPAiHPA014704.
HPA023890.
MIMi607887. gene.
neXtProtiNX_Q8IZR5.
PharmGKBiPA38814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG320824.
GeneTreeiENSGT00530000063578.
HOGENOMiHOG000261609.
HOVERGENiHBG050980.
InParanoidiQ8IZR5.
OMAiAVQKWRV.
OrthoDBiEOG7FNC8Q.
PhylomeDBiQ8IZR5.
TreeFamiTF317387.

Miscellaneous databases

ChiTaRSiCMTM4. human.
GenomeRNAii146223.
NextBioi85306.
PROiQ8IZR5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZR5.
CleanExiHS_CMTM4.
ExpressionAtlasiQ8IZR5. baseline and differential.
GenevestigatoriQ8IZR5.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ding P., Han W., Shi S., Yang T., Song Q., Zhang Y., Ma D.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Tissue: Kidney.
  2. "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
    Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
    Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCKLF4_HUMAN
AccessioniPrimary (citable) accession number: Q8IZR5
Secondary accession number(s): Q52M40, Q8IZR4, Q8IZV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.