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Protein

CKLF-like MARVEL transmembrane domain-containing protein 4

Gene

CMTM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciZFISH:G66-32405-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 4
Alternative name(s):
Chemokine-like factor superfamily member 4
Gene namesi
Name:CMTM4
Synonyms:CKLFSF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19175. CMTM4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi146223.
OpenTargetsiENSG00000183723.
PharmGKBiPA38814.

Polymorphism and mutation databases

BioMutaiCMTM4.
DMDMi34921813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861031 – 234CKLF-like MARVEL transmembrane domain-containing protein 4Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IZR5.
PaxDbiQ8IZR5.
PeptideAtlasiQ8IZR5.
PRIDEiQ8IZR5.

PTM databases

iPTMnetiQ8IZR5.
PhosphoSitePlusiQ8IZR5.
SwissPalmiQ8IZR5.

Expressioni

Tissue specificityi

Highly expressed in testis and prostate.1 Publication

Gene expression databases

BgeeiENSG00000183723.
CleanExiHS_CMTM4.
ExpressionAtlasiQ8IZR5. baseline and differential.
GenevisibleiQ8IZR5. HS.

Organism-specific databases

HPAiHPA014704.
HPA023890.

Interactioni

Protein-protein interaction databases

BioGridi126972. 10 interactors.
IntActiQ8IZR5. 2 interactors.
STRINGi9606.ENSP00000333833.

Structurei

3D structure databases

ProteinModelPortaliQ8IZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 176MARVELPROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063578.
HOGENOMiHOG000261609.
HOVERGENiHBG050980.
InParanoidiQ8IZR5.
OMAiAVQKWRV.
OrthoDBiEOG091G0KPO.
PhylomeDBiQ8IZR5.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL
60 70 80 90 100
RGALGRLKVA QVILALIAFI CIETIMACSP CEGLYFFEFV SCSAFVVTGV
110 120 130 140 150
LLIMFSLNLH MRIPQINWNL TDLVNTGLSA FLFFIASIVL AALNHRAGAE
160 170 180 190 200
IAAVIFGFLA TAAYAVNTFL AVQKWRVSVR QQSTNDYIRA RTESRDVDSR
210 220 230
PEIQRLDTFS YSTNVTVRKK SPTNLLSLNH WQLA
Length:234
Mass (Da):25,828
Last modified:March 1, 2003 - v1
Checksum:i629B5CCEE873C895
GO
Isoform 2 (identifier: Q8IZR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-234: Missing.

Show »
Length:208
Mass (Da):22,840
Checksum:iEF8B0E6B5D8590A4
GO
Isoform 3 (identifier: Q8IZR5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-62: Missing.
     209-234: Missing.

Show »
Length:179
Mass (Da):19,690
Checksum:i26A798C438B1C196
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00826034 – 62Missing in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_008261209 – 234Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521889 mRNA. Translation: AAN73845.1.
AF521890 mRNA. Translation: AAN73846.1.
AF479814 mRNA. Translation: AAN73436.1.
BC093679 mRNA. Translation: AAH93679.1.
CCDSiCCDS10817.1. [Q8IZR5-1]
CCDS42170.1. [Q8IZR5-2]
RefSeqiNP_848933.1. NM_178818.2. [Q8IZR5-1]
NP_852662.1. NM_181521.2. [Q8IZR5-2]
XP_011521184.1. XM_011522882.1. [Q8IZR5-3]
UniGeneiHs.643961.

Genome annotation databases

EnsembliENST00000330687; ENSP00000333833; ENSG00000183723. [Q8IZR5-1]
ENST00000394106; ENSP00000377666; ENSG00000183723. [Q8IZR5-2]
ENST00000563952; ENSP00000456380; ENSG00000183723. [Q8IZR5-3]
GeneIDi146223.
KEGGihsa:146223.
UCSCiuc002epz.3. human. [Q8IZR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521889 mRNA. Translation: AAN73845.1.
AF521890 mRNA. Translation: AAN73846.1.
AF479814 mRNA. Translation: AAN73436.1.
BC093679 mRNA. Translation: AAH93679.1.
CCDSiCCDS10817.1. [Q8IZR5-1]
CCDS42170.1. [Q8IZR5-2]
RefSeqiNP_848933.1. NM_178818.2. [Q8IZR5-1]
NP_852662.1. NM_181521.2. [Q8IZR5-2]
XP_011521184.1. XM_011522882.1. [Q8IZR5-3]
UniGeneiHs.643961.

3D structure databases

ProteinModelPortaliQ8IZR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126972. 10 interactors.
IntActiQ8IZR5. 2 interactors.
STRINGi9606.ENSP00000333833.

PTM databases

iPTMnetiQ8IZR5.
PhosphoSitePlusiQ8IZR5.
SwissPalmiQ8IZR5.

Polymorphism and mutation databases

BioMutaiCMTM4.
DMDMi34921813.

Proteomic databases

MaxQBiQ8IZR5.
PaxDbiQ8IZR5.
PeptideAtlasiQ8IZR5.
PRIDEiQ8IZR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330687; ENSP00000333833; ENSG00000183723. [Q8IZR5-1]
ENST00000394106; ENSP00000377666; ENSG00000183723. [Q8IZR5-2]
ENST00000563952; ENSP00000456380; ENSG00000183723. [Q8IZR5-3]
GeneIDi146223.
KEGGihsa:146223.
UCSCiuc002epz.3. human. [Q8IZR5-1]

Organism-specific databases

CTDi146223.
DisGeNETi146223.
GeneCardsiCMTM4.
HGNCiHGNC:19175. CMTM4.
HPAiHPA014704.
HPA023890.
MIMi607887. gene.
neXtProtiNX_Q8IZR5.
OpenTargetsiENSG00000183723.
PharmGKBiPA38814.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063578.
HOGENOMiHOG000261609.
HOVERGENiHBG050980.
InParanoidiQ8IZR5.
OMAiAVQKWRV.
OrthoDBiEOG091G0KPO.
PhylomeDBiQ8IZR5.
TreeFamiTF317387.

Enzyme and pathway databases

BioCyciZFISH:G66-32405-MONOMER.

Miscellaneous databases

ChiTaRSiCMTM4. human.
GenomeRNAii146223.
PROiQ8IZR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183723.
CleanExiHS_CMTM4.
ExpressionAtlasiQ8IZR5. baseline and differential.
GenevisibleiQ8IZR5. HS.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKLF4_HUMAN
AccessioniPrimary (citable) accession number: Q8IZR5
Secondary accession number(s): Q52M40, Q8IZR4, Q8IZV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.