Q8IZQ8 (MYCD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myocardin

Gene names

Name:	MYOCD
Synonyms:	MYCD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	938 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) By similarity. Ref.2
Subunit structure	Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation By similarity. Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 By similarity. Interacts with MEF2C By similarity. Ref.8
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder, small intestine, colon, lung, placenta and uterus. Very faint expression in prostate and skeletal muscle. Ref.2 Ref.9
Induction	Up-regulated during heart failure. Ref.7
Domain	The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation By similarity.
Post-translational modification	Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity By similarity.
Sequence similarities	Contains 3 RPEL repeats. Contains 1 SAP domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac muscle cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL cardiac ventricle development Inferred from electronic annotation. Source: Compara cell growth involved in cardiac muscle cell development Inferred from electronic annotation. Source: Compara cellular response to growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to hypoxia Inferred from electronic annotation. Source: Compara digestive tract development Inferred from electronic annotation. Source: Compara ductus arteriosus closure Inferred from electronic annotation. Source: Compara hepatic stellate cell activation Inferred from electronic annotation. Source: Compara lung alveolus development Inferred from electronic annotation. Source: Compara negative regulation of beta-amyloid clearance Inferred from mutant phenotype PubMed 19098903. Source: BHF-UCL negative regulation of cardiac muscle cell apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from direct assay PubMed 18451334. Source: BHF-UCL negative regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from direct assay PubMed 18451334. Source: BHF-UCL negative regulation of myotube differentiation Inferred from electronic annotation. Source: Compara negative regulation of skeletal muscle cell differentiation Inferred from direct assay PubMed 18451334. Source: BHF-UCL negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of DNA binding Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle cell differentiation Inferred from direct assay PubMed 18451334. Source: BHF-UCL positive regulation of cardiac vascular smooth muscle cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 19098903. Source: BHF-UCL positive regulation of smooth muscle contraction Inferred from direct assay PubMed 17215356. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Inferred from direct assay Ref.3. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Inferred from direct assay Ref.3. Source: BHF-UCL positive regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of cell growth by extracellular stimulus Inferred from electronic annotation. Source: Compara regulation of histone acetylation Inferred from sequence or structural similarity. Source: UniProtKB regulation of myoblast differentiation Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from expression pattern PubMed 19098903. Source: BHF-UCL urinary bladder development Inferred from electronic annotation. Source: Compara uterus development Inferred from electronic annotation. Source: Compara vasculogenesis Inferred from electronic annotation. Source: Compara ventricular cardiac muscle cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from direct assay PubMed 14970199. Source: BHF-UCL
Molecular_function	RNA polymerase II transcription factor binding transcription factor activity Inferred from sequence or structural similarity. Source: BHF-UCL core promoter sequence-specific DNA binding Inferred from direct assay PubMed 19797053. Source: UniProtKB protein domain specific binding Inferred from direct assay PubMed 19797053. Source: UniProtKB transcription coactivator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SRF	P11831	2	EBI-493384,EBI-493034

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZQ8-1)

Also known as: Myocardin-A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZQ8-2)

Also known as: Myocardin-C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     686-686: Q → QNSGAHDGHPPSFSPHSSSLHPPFSGAQADSSHGAGGNPCPKSPCVQQK
     730-732: QMT → VTM
     733-938: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8IZQ8-3)

Also known as: Myocardin-B;

The sequence of this isoform differs from the canonical sequence as follows:
     686-686: Q → QNSGAHDGHPPSFSPHSSSLHPPFSGAQADSSHGAGGNPCPKSPCVQQK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 938	938	Myocardin		PRO_0000126631
Regions
	Repeat	18 – 43	26	RPEL 1
	Repeat	62 – 87	26	RPEL 2
	Repeat	106 – 131	26	RPEL 3
	Domain	371 – 405	35	SAP
	Region	153 – 205	53	HDAC5-binding By similarity
	Coiled coil	516 – 561	46	Potential
	Motif	12 – 27	16	MEF2C-binding By similarity
	Compositional bias	291 – 322	32	Gln-rich
	Compositional bias	435 – 508	74	Ser-rich
Amino acid modifications
	Modified residue	451	1	Phosphoserine; by GSK3-beta By similarity
	Modified residue	455	1	Phosphoserine; by GSK3-beta By similarity
	Modified residue	459	1	Phosphoserine; by GSK3-beta By similarity
	Modified residue	463	1	Phosphoserine; by GSK3-beta By similarity
	Modified residue	626	1	Phosphoserine; by GSK3-beta By similarity
	Modified residue	630	1	Phosphoserine; by GSK3-beta By similarity
	Modified residue	634	1	Phosphoserine; by GSK3-beta By similarity
	Modified residue	638	1	Phosphoserine; by GSK3-beta By similarity
	Modified residue	815	1	Phosphoserine; by MAPK1 AND MAPK3 By similarity
	Modified residue	862	1	Phosphoserine; by MAPK1 and MAPK3 By similarity
	Modified residue	869	1	Phosphoserine; by MAPK1 and MAPK3 By similarity
	Modified residue	896	1	Phosphothreonine; by MAPK1 and MAPK3 By similarity
Natural variations
	Alternative sequence	1 – 96	96	Missing in isoform 2.		VSP_007658
	Alternative sequence	686	1	Q → QNSGAHDGHPPSFSPHSSSL HPPFSGAQADSSHGAGGNPC PKSPCVQQK in isoform 2 and isoform 3.		VSP_007659
	Alternative sequence	730 – 732	3	QMT → VTM in isoform 2.		VSP_007660
	Alternative sequence	733 – 938	206	Missing in isoform 2.		VSP_007661

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Myocardin-A) [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 295F66A02725B0A5	FASTA	938	101,997
	10 20 30 40 50 60 MTLLGSEHSL LIRSKFRSVL QLRLQQRRTQ EQLANQGIIP PLKRPAEFHE QRKHLDSDKA 70 80 90 100 110 120 KNSLKRKARN RCNSADLVNM HILQASTAER SIPTAQMKLK RARLADDLNE KIALRPGPLE 130 140 150 160 170 180 LVEKNILPVD SAVKEAIKGN QVSFSKSTDA FAFEEDSSSD GLSPDQTRSE DPQNSAGSPP 190 200 210 220 230 240 DAKASDTPST GSLGTNQDLA SGSENDRNDS ASQPSHQSDA GKQGLGPPST PIAVHAAVKS 250 260 270 280 290 300 KSLGDSKNRH KKPKDPKPKV KKLKYHQYIP PDQKAEKSPP PMDSAYARLL QQQQLFLQLQ 310 320 330 340 350 360 ILSQQQQQQQ HRFSYLGMHQ AQLKEPNEQM VRNPNSSSTP LSNTPLSPVK NSFSGQTGVS 370 380 390 400 410 420 SFKPGPLPPN LDDLKVSELR QQLRIRGLPV SGTKTALMDR LRPFQDCSGN PVPNFGDITT 430 440 450 460 470 480 VTFPVTPNTL PNYQSSSSTS ALSNGFYHFG STSSSPPISP ASSDLSVAGS LPDTFNDASP 490 500 510 520 530 540 SFGLHPSPVH VCTEESLMSS LNGGSVPSEL DGLDSEKDKM LVEKQKVINE LTWKLQQEQR 550 560 570 580 590 600 QVEELRMQLQ KQKRNNCSEK KPLPFLAASI KQEEAVSSCP FASQVPVKRQ SSSSECHPPA 610 620 630 640 650 660 CEAAQLQPLG NAHCVESSDQ TNVLSSTFLS PQCSPQHSPL GAVKSPQHIS LPPSPNNPHF 670 680 690 700 710 720 LPSSSGAQGE GHRVSSPISS QVCTAQMAGL HSSDKVGPKF SIPSPTFSKS SSAISEVTQP 730 740 750 760 770 780 PSYEDAVKQQ MTRSQQMDEL LDVLIESGEM PADAREDHSC LQKVPKIPRS SRSPTAVLTK 790 800 810 820 830 840 PSASFEQASS GSQIPFDPYA TDSDEHLEVL LNSQSPLGKM SDVTLLKIGS EEPHFDGIMD 850 860 870 880 890 900 GFSGKAAEDL FNAHEILPGP LSPMQTQFSP SSVDSNGLQL SFTESPWETM EWLDLTPPNS 910 920 930 TPGFSALTTS SPSIFNIDFL DVTDLNLNSS MDLHLQQW
	Isoform 2 (Myocardin-C) [UniParc]. Checksum: 78D7F120161A7626	FASTA	684	73,183
	10 20 30 40 50 60 MKLKRARLAD DLNEKIALRP GPLELVEKNI LPVDSAVKEA IKGNQVSFSK STDAFAFEED 70 80 90 100 110 120 SSSDGLSPDQ TRSEDPQNSA GSPPDAKASD TPSTGSLGTN QDLASGSEND RNDSASQPSH 130 140 150 160 170 180 QSDAGKQGLG PPSTPIAVHA AVKSKSLGDS KNRHKKPKDP KPKVKKLKYH QYIPPDQKAE 190 200 210 220 230 240 KSPPPMDSAY ARLLQQQQLF LQLQILSQQQ QQQQHRFSYL GMHQAQLKEP NEQMVRNPNS 250 260 270 280 290 300 SSTPLSNTPL SPVKNSFSGQ TGVSSFKPGP LPPNLDDLKV SELRQQLRIR GLPVSGTKTA 310 320 330 340 350 360 LMDRLRPFQD CSGNPVPNFG DITTVTFPVT PNTLPNYQSS SSTSALSNGF YHFGSTSSSP 370 380 390 400 410 420 PISPASSDLS VAGSLPDTFN DASPSFGLHP SPVHVCTEES LMSSLNGGSV PSELDGLDSE 430 440 450 460 470 480 KDKMLVEKQK VINELTWKLQ QEQRQVEELR MQLQKQKRNN CSEKKPLPFL AASIKQEEAV 490 500 510 520 530 540 SSCPFASQVP VKRQSSSSEC HPPACEAAQL QPLGNAHCVE SSDQTNVLSS TFLSPQCSPQ 550 560 570 580 590 600 HSPLGAVKSP QHISLPPSPN NPHFLPSSSG AQGEGHRVSS PISSQVCTAQ NSGAHDGHPP 610 620 630 640 650 660 SFSPHSSSLH PPFSGAQADS SHGAGGNPCP KSPCVQQKMA GLHSSDKVGP KFSIPSPTFS 670 680 KSSSAISEVT QPPSYEDAVK QVTM
	Isoform 3 (Myocardin-B) [UniParc]. Checksum: 4FF5FCD468EEB86F	FASTA	986	106,769
	10 20 30 40 50 60 MTLLGSEHSL LIRSKFRSVL QLRLQQRRTQ EQLANQGIIP PLKRPAEFHE QRKHLDSDKA 70 80 90 100 110 120 KNSLKRKARN RCNSADLVNM HILQASTAER SIPTAQMKLK RARLADDLNE KIALRPGPLE 130 140 150 160 170 180 LVEKNILPVD SAVKEAIKGN QVSFSKSTDA FAFEEDSSSD GLSPDQTRSE DPQNSAGSPP 190 200 210 220 230 240 DAKASDTPST GSLGTNQDLA SGSENDRNDS ASQPSHQSDA GKQGLGPPST PIAVHAAVKS 250 260 270 280 290 300 KSLGDSKNRH KKPKDPKPKV KKLKYHQYIP PDQKAEKSPP PMDSAYARLL QQQQLFLQLQ 310 320 330 340 350 360 ILSQQQQQQQ HRFSYLGMHQ AQLKEPNEQM VRNPNSSSTP LSNTPLSPVK NSFSGQTGVS 370 380 390 400 410 420 SFKPGPLPPN LDDLKVSELR QQLRIRGLPV SGTKTALMDR LRPFQDCSGN PVPNFGDITT 430 440 450 460 470 480 VTFPVTPNTL PNYQSSSSTS ALSNGFYHFG STSSSPPISP ASSDLSVAGS LPDTFNDASP 490 500 510 520 530 540 SFGLHPSPVH VCTEESLMSS LNGGSVPSEL DGLDSEKDKM LVEKQKVINE LTWKLQQEQR 550 560 570 580 590 600 QVEELRMQLQ KQKRNNCSEK KPLPFLAASI KQEEAVSSCP FASQVPVKRQ SSSSECHPPA 610 620 630 640 650 660 CEAAQLQPLG NAHCVESSDQ TNVLSSTFLS PQCSPQHSPL GAVKSPQHIS LPPSPNNPHF 670 680 690 700 710 720 LPSSSGAQGE GHRVSSPISS QVCTAQNSGA HDGHPPSFSP HSSSLHPPFS GAQADSSHGA 730 740 750 760 770 780 GGNPCPKSPC VQQKMAGLHS SDKVGPKFSI PSPTFSKSSS AISEVTQPPS YEDAVKQQMT 790 800 810 820 830 840 RSQQMDELLD VLIESGEMPA DAREDHSCLQ KVPKIPRSSR SPTAVLTKPS ASFEQASSGS 850 860 870 880 890 900 QIPFDPYATD SDEHLEVLLN SQSPLGKMSD VTLLKIGSEE PHFDGIMDGF SGKAAEDLFN 910 920 930 940 950 960 AHEILPGPLS PMQTQFSPSS VDSNGLQLSF TESPWETMEW LDLTPPNSTP GFSALTTSSP 970 980 SIFNIDFLDV TDLNLNSSMD LHLQQW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Potentiation of serum response factor activity by a family of myocardin-related transcription factors." Wang D.-Z., Li S., Hockemeyer D., Sutherland L., Wang Z., Schratt G., Richardson J.A., Nordheim A., Olson E.N. Proc. Natl. Acad. Sci. U.S.A. 99:14855-14860(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation." Du K.L., Ip H.S., Li J., Chen M., Dandre F., Yu W., Lu M.M., Owens G.K., Parmacek M.S. Mol. Cell. Biol. 23:2425-2437(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY. Tissue: Heart.
[3]	"Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin." van Tuyn J., Knaan-Shanzer S., van de Watering M.J., de Graaf M., van der Laarse A., Schalij M.J., van der Wall E.E., de Vries A.A., Atsma D.E. Cardiovasc. Res. 67:245-255(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Testis.
[5]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[7]	"Myocardin mRNA is augmented in the failing myocardium: expression profiling in the porcine model and human dilated cardiomyopathy." Torrado M., Lopez E., Centeno A., Medrano C., Castro-Beiras A., Mikhailov A.T. J. Mol. Med. 81:566-577(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3), INDUCTION.
[8]	"Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin." Liu Z.-P., Wang Z., Yanagisawa H., Olson E.N. Dev. Cell 9:261-270(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MLLT7.
[9]	"Expression and functional activity of four myocardin isoforms." Imamura M., Long X., Nanda V., Miano J.M. Gene 464:1-10(2010) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY OF ISOFORMS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF532596 mRNA. Translation: AAN33040.1. AY764180 mRNA. Translation: AAV33439.1. AK292885 mRNA. Translation: BAF85574.1. AK097821 mRNA. Translation: BAC05177.1. AC005358 Genomic DNA. No translation available. BC126307 mRNA. Translation: AAI26308.1. BC143391 mRNA. Translation: AAI43392.1.
IPI	IPI00167260. IPI00218055. IPI00333359.
RefSeq	NP_001139784.1. NM_001146312.1. NP_001139785.1. NM_001146313.1. NP_705832.1. NM_153604.2.
UniGene	Hs.567641.
3D structure databases
ProteinModelPortal	Q8IZQ8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZQ8. 2 interactions.
STRING	9606.ENSP00000341835.
PTM databases
PhosphoSite	Q8IZQ8.
Polymorphism databases
DMDM	32363335.
Proteomic databases
PaxDb	Q8IZQ8.
PRIDE	Q8IZQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343344; ENSP00000341835; ENSG00000141052. ENST00000395988; ENSP00000379311; ENSG00000141052. ENST00000425538; ENSP00000401678; ENSG00000141052.
GeneID	93649.
KEGG	hsa:93649.
UCSC	uc002gnn.2. human. uc002gno.2. human. uc002gnp.1. human.
Organism-specific databases
CTD	93649.
GeneCards	GC17P012569.
H-InvDB	HIX0027347.
HGNC	HGNC:16067. MYOCD.
HPA	CAB046485.
MIM	606127. gene.
neXtProt	NX_Q8IZQ8.
PharmGKB	PA134946896.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG79803.
HOGENOM	HOG000038001.
HOVERGEN	HBG036493.
OMA	SFTESPW.
OrthoDB	EOG4640BZ.
PhylomeDB	Q8IZQ8.
Gene expression databases
ArrayExpress	Q8IZQ8.
Bgee	Q8IZQ8.
CleanEx	HS_MYOCD.
Genevestigator	Q8IZQ8.
GermOnline	ENSG00000141052. Homo sapiens.
Family and domain databases
Gene3D	1.10.720.30. 1 hit.
InterPro	IPR004018. RPEL_repeat. IPR003034. SAP_dom. [Graphical view]
Pfam	PF02755. RPEL. 1 hit. PF02037. SAP. 1 hit. [Graphical view]
SMART	SM00707. RPEL. 3 hits. SM00513. SAP. 1 hit. [Graphical view]
PROSITE	PS51073. RPEL. 3 hits. PS50800. SAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	93649.
NextBio	78180.
SOURCE	Search...

Entry information

Entry name

MYCD_HUMAN

Accession

Primary (citable) accession number: Q8IZQ8
Secondary accession number(s): Q5UBU5, Q8N7Q1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.