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Protein

Selenoprotein H

Gene

SELH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in a redox-related process.Curated

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein H
Short name:
SelH
Gene namesi
Name:SELH
Synonyms:C11orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18251. C11orf31.

Pathology & Biotechi

Organism-specific databases

DisGeNETi280636.
OpenTargetsiENSG00000211450.
PharmGKBiPA25495.

Polymorphism and mutation databases

BioMutaiSELH.
DMDMi190352213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976671 – 122Selenoprotein HAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20N6-acetyllysineCombined sources1
Cross-linki41 ↔ 44Cysteinyl-selenocysteine (Cys-Sec); redox-activeBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8IZQ5.
MaxQBiQ8IZQ5.
PaxDbiQ8IZQ5.
PeptideAtlasiQ8IZQ5.
PRIDEiQ8IZQ5.

PTM databases

iPTMnetiQ8IZQ5.
PhosphoSitePlusiQ8IZQ5.
SwissPalmiQ8IZQ5.

Expressioni

Gene expression databases

BgeeiENSG00000211450.
CleanExiHS_C11orf31.
ExpressionAtlasiQ8IZQ5. baseline and differential.
GenevisibleiQ8IZQ5. HS.

Organism-specific databases

HPAiHPA048362.

Interactioni

Protein-protein interaction databases

BioGridi129373. 4 interactors.
IntActiQ8IZQ5. 4 interactors.
STRINGi9606.ENSP00000373509.

Structurei

3D structure databases

ProteinModelPortaliQ8IZQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelWTH family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG410IZ8H. Eukaryota.
ENOG410Y6GD. LUCA.
GeneTreeiENSGT00390000004084.
HOGENOMiHOG000046769.
HOVERGENiHBG108466.
InParanoidiQ8IZQ5.
OMAiHRVYGRN.
OrthoDBiEOG091G13XT.
PhylomeDBiQ8IZQ5.
TreeFamiTF343373.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IZQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRGRKRKA EAAVVAVAEK REKLANGGEG MEEATVVIEH CTSURVYGRN
60 70 80 90 100
AAALSQALRL EAPELPVKVN PTKPRRGSFE VTLLRPDGSS AELWTGIKKG
110 120
PPRKLKFPEP QEVVEELKKY LS
Length:122
Mass (Da):13,453
Last modified:February 26, 2008 - v2
Checksum:iB7EF30180573D4D5
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei44Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF536829 mRNA. Translation: AAN61472.1.
BC021122 mRNA. Translation: AAH21122.2.
CCDSiCCDS44602.1.
RefSeqiNP_001308264.1. NM_001321335.1.
NP_734467.1. NM_170746.3.
UniGeneiHs.655373.
Hs.745174.

Genome annotation databases

EnsembliENST00000388857; ENSP00000373509; ENSG00000211450.
ENST00000534355; ENSP00000434511; ENSG00000211450.
GeneIDi280636.
KEGGihsa:280636.
UCSCiuc021qjj.2. human.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF536829 mRNA. Translation: AAN61472.1.
BC021122 mRNA. Translation: AAH21122.2.
CCDSiCCDS44602.1.
RefSeqiNP_001308264.1. NM_001321335.1.
NP_734467.1. NM_170746.3.
UniGeneiHs.655373.
Hs.745174.

3D structure databases

ProteinModelPortaliQ8IZQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129373. 4 interactors.
IntActiQ8IZQ5. 4 interactors.
STRINGi9606.ENSP00000373509.

PTM databases

iPTMnetiQ8IZQ5.
PhosphoSitePlusiQ8IZQ5.
SwissPalmiQ8IZQ5.

Polymorphism and mutation databases

BioMutaiSELH.
DMDMi190352213.

Proteomic databases

EPDiQ8IZQ5.
MaxQBiQ8IZQ5.
PaxDbiQ8IZQ5.
PeptideAtlasiQ8IZQ5.
PRIDEiQ8IZQ5.

Protocols and materials databases

DNASUi280636.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388857; ENSP00000373509; ENSG00000211450.
ENST00000534355; ENSP00000434511; ENSG00000211450.
GeneIDi280636.
KEGGihsa:280636.
UCSCiuc021qjj.2. human.

Organism-specific databases

CTDi280636.
DisGeNETi280636.
GeneCardsiC11orf31.
H-InvDBHIX0035861.
HIX0201775.
HGNCiHGNC:18251. C11orf31.
HPAiHPA048362.
MIMi607914. gene.
neXtProtiNX_Q8IZQ5.
OpenTargetsiENSG00000211450.
PharmGKBiPA25495.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ8H. Eukaryota.
ENOG410Y6GD. LUCA.
GeneTreeiENSGT00390000004084.
HOGENOMiHOG000046769.
HOVERGENiHBG108466.
InParanoidiQ8IZQ5.
OMAiHRVYGRN.
OrthoDBiEOG091G13XT.
PhylomeDBiQ8IZQ5.
TreeFamiTF343373.

Enzyme and pathway databases

BioCyciZFISH:G66-33361-MONOMER.

Miscellaneous databases

GenomeRNAii280636.
PROiQ8IZQ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211450.
CleanExiHS_C11orf31.
ExpressionAtlasiQ8IZQ5. baseline and differential.
GenevisibleiQ8IZQ5. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSELH_HUMAN
AccessioniPrimary (citable) accession number: Q8IZQ5
Secondary accession number(s): Q8N672
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.