##gff-version 3 Q8IZQ1 UniProtKB Chain 1 3526 . . . ID=PRO_0000242693;Note=WD repeat and FYVE domain-containing protein 3 Q8IZQ1 UniProtKB Domain 2531 2656 . . . Note=BEACH-type PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01119 Q8IZQ1 UniProtKB Domain 2683 2976 . . . Note=BEACH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00026 Q8IZQ1 UniProtKB Repeat 3077 3115 . . . Note=WD 1 Q8IZQ1 UniProtKB Repeat 3125 3164 . . . Note=WD 2 Q8IZQ1 UniProtKB Repeat 3167 3206 . . . Note=WD 3 Q8IZQ1 UniProtKB Repeat 3210 3254 . . . Note=WD 4 Q8IZQ1 UniProtKB Repeat 3408 3447 . . . Note=WD 5 Q8IZQ1 UniProtKB Zinc finger 3454 3514 . . . Note=FYVE-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091 Q8IZQ1 UniProtKB Region 2285 2981 . . . Note=Sufficient for localization to p62 bodies/ALIS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20168092;Dbxref=PMID:20168092 Q8IZQ1 UniProtKB Region 2403 2429 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IZQ1 UniProtKB Region 2459 2522 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IZQ1 UniProtKB Region 2586 3526 . . . Note=Interaction with SQSTM1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20168092;Dbxref=PMID:20168092 Q8IZQ1 UniProtKB Region 2981 3526 . . . Note=Interaction with ATG5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20417604;Dbxref=PMID:20417604 Q8IZQ1 UniProtKB Region 3272 3335 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IZQ1 UniProtKB Region 3313 3363 . . . Note=Interaction with GABARAP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24668264;Dbxref=PMID:24668264 Q8IZQ1 UniProtKB Motif 3346 3349 . . . Note=LC3-interacting region (LIR);Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:24668264;Dbxref=PMID:24668264 Q8IZQ1 UniProtKB Compositional bias 2464 2478 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IZQ1 UniProtKB Compositional bias 3274 3289 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IZQ1 UniProtKB Compositional bias 3295 3313 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8IZQ1 UniProtKB Binding site 3460 3460 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091 Q8IZQ1 UniProtKB Binding site 3463 3463 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091 Q8IZQ1 UniProtKB Binding site 3476 3476 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091 Q8IZQ1 UniProtKB Binding site 3479 3479 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091 Q8IZQ1 UniProtKB Binding site 3484 3484 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091 Q8IZQ1 UniProtKB Binding site 3487 3487 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091 Q8IZQ1 UniProtKB Binding site 3506 3506 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091 Q8IZQ1 UniProtKB Binding site 3509 3509 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00091 Q8IZQ1 UniProtKB Modified residue 1942 1942 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6VNB8 Q8IZQ1 UniProtKB Modified residue 2278 2278 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8IZQ1 UniProtKB Modified residue 2492 2492 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6VNB8 Q8IZQ1 UniProtKB Modified residue 3335 3335 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6VNB8 Q8IZQ1 UniProtKB Modified residue 3339 3339 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8IZQ1 UniProtKB Alternative sequence 2408 2424 . . . ID=VSP_019475;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8IZQ1 UniProtKB Natural variant 2637 2637 . . . ID=VAR_079130;Note=In MCPH18%3B increased cellular DVL3 protein levels as compared to the wild-type protein and loss of attenuation of Wnt signaling%3B when expressed in Drosophila%2C causes brain anomalies. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27008544;Dbxref=dbSNP:rs1553924800,PMID:27008544 Q8IZQ1 UniProtKB Natural variant 3032 3032 . . . ID=VAR_026864;Note=I->V;Dbxref=dbSNP:rs17368018 Q8IZQ1 UniProtKB Mutagenesis 3343 3343 . . . Note=Decreased interaction with GABARAP%2C no effect on interaction with MAP1LC3B%3B when associated with A-3344 and A-3351. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24668264;Dbxref=PMID:24668264 Q8IZQ1 UniProtKB Mutagenesis 3344 3344 . . . Note=Decreased interaction with GABARAP%2C no effect on interaction with MAP1LC3B%3B when associated with A-3343 and A-3351. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24668264;Dbxref=PMID:24668264 Q8IZQ1 UniProtKB Mutagenesis 3346 3346 . . . Note=Abolishes interaction with GABARAP and MAP1LC3C. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24668264;Dbxref=PMID:24668264 Q8IZQ1 UniProtKB Mutagenesis 3347 3347 . . . Note=Decreases interaction with GABARAP and MAP1LC3C. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24668264;Dbxref=PMID:24668264 Q8IZQ1 UniProtKB Mutagenesis 3348 3348 . . . Note=Decreases interaction with GABARAP and MAP1LC3C. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24668264;Dbxref=PMID:24668264 Q8IZQ1 UniProtKB Mutagenesis 3349 3349 . . . Note=Decreases interaction with GABARAP and MAP1LC3C. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24668264;Dbxref=PMID:24668264 Q8IZQ1 UniProtKB Mutagenesis 3351 3351 . . . Note=Decreased interaction with GABARAP%2C no effect on interaction with MAP1LC3B%3B when associated with A-3343 and A-3344. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24668264;Dbxref=PMID:24668264 Q8IZQ1 UniProtKB Sequence conflict 2944 2944 . . . Note=N->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IZQ1 UniProtKB Sequence conflict 3396 3396 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8IZQ1 UniProtKB Beta strand 3346 3348 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3WIM Q8IZQ1 UniProtKB Beta strand 3456 3459 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Beta strand 3461 3463 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Beta strand 3469 3471 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Beta strand 3473 3475 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Turn 3477 3479 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Beta strand 3482 3484 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Turn 3485 3487 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Beta strand 3492 3494 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Helix 3495 3497 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Beta strand 3499 3503 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N Q8IZQ1 UniProtKB Helix 3507 3514 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6W9N