Q8IZQ1 (WDFY3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat and FYVE domain-containing protein 3

Alternative name(s):
Autophagy-linked FYVE protein
Short name=Alfy

Gene names

Name:	WDFY3
Synonyms:	KIAA0993

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	3526 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Peripheral membrane protein; Cytoplasmic side. Note: Co-localizes with autophagic structures in starved cells. Ref.1
Tissue specificity	Ubiquitous. Ref.1
Sequence similarities	Contains 1 BEACH domain. Contains 1 FYVE-type zinc finger. Contains 5 WD repeats.
Sequence caution	The sequence AAH13377.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH15214.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB71020.1 differs from that shown. Reason: Aberrant splicing. The sequence BAC04455.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasmic part Inferred from direct assay Ref.1. Source: MGI extrinsic to membrane Inferred from direct assay Ref.1. Source: MGI nuclear envelope Inferred from direct assay Ref.1. Source: MGI
Molecular function	1-phosphatidylinositol binding Inferred from direct assay Ref.1. Source: MGI metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATG5	Q9H1Y0	6	EBI-1569256,EBI-1047414
HTT	P42858	11	EBI-1569256,EBI-466029

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZQ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2408-2424: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3526	3526	WD repeat and FYVE domain-containing protein 3		PRO_0000242693
Regions
	Domain	2683 – 2976	294	BEACH
	Repeat	3077 – 3115	39	WD 1
	Repeat	3125 – 3164	40	WD 2
	Repeat	3167 – 3206	40	WD 3
	Repeat	3210 – 3254	45	WD 4
	Repeat	3408 – 3447	40	WD 5
	Zinc finger	3454 – 3514	61	FYVE-type
	Compositional bias	472 – 475	4	Poly-Ser
	Compositional bias	2516 – 2519	4	Poly-Glu
Amino acid modifications
	Modified residue	653	1	Phosphotyrosine Ref.7
	Modified residue	813	1	Phosphotyrosine Ref.9
	Modified residue	815	1	Phosphoserine Ref.9
	Modified residue	817	1	Phosphoserine Ref.9
	Modified residue	818	1	Phosphothreonine Ref.9
	Modified residue	822	1	Phosphotyrosine Ref.9
	Modified residue	1696	1	Phosphoserine Ref.8
	Modified residue	1699	1	Phosphoserine Ref.8
	Modified residue	3335	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	2408 – 2424	17	Missing in isoform 2.		VSP_019475
	Natural variant	3032	1	I → V. Corresponds to variant rs17368018 [ dbSNP | Ensembl ].		VAR_026864
Experimental info
	Sequence conflict	2944	1	N → T in AAN15137. Ref.1
	Sequence conflict	3396	1	L → P in BAB71020. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: F4D518E8C9C12E23	FASTA	3,526	395,258
	10 20 30 40 50 60 MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR 70 80 90 100 110 120 VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEAASRAIVQ FLEINQSEEA 130 140 150 160 170 180 SRGWMLLTTI NLLASSGQKT VDCMTTMSVP STLVKCLYLF FDLPHVPEAV GGAQNELPLA 190 200 210 220 230 240 ERRGLLQKVF VQILVKLCSF VSPAEELAQK DDLQLLFSAI TSWCPPYNLP WRKSAGEVLM 250 260 270 280 290 300 TISRHGLSVN VVKYIHEKEC LSTCVQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL 310 320 330 340 350 360 LDDFRIWQGY NFLCDLLLRL EQAKEAESKD ALKDLVNLIT SLTTYGVSEL KPAGITTGAP 370 380 390 400 410 420 FLLPGFAVPQ PAGKGHSVRN VQAFAVLQNA FLKAKTSFLA QIILDAITNI YMADNANYFI 430 440 450 460 470 480 LESQHTLSQF AEKISKLPEV QNKYFEMLEF VVFSLNYIPC KELISVSILL KSSSSYHCSI 490 500 510 520 530 540 IAMKTLLKFT RHDYIFKDVF REVGLLEVMV NLLHKYAALL KDPTQALNEQ GDSRNNSSVE 550 560 570 580 590 600 DQKHLALLVM ETLTVLLQGS NTNAGIFREF GGARCAHNIV KYPQCRQHAL MTIQQLVLSP 610 620 630 640 650 660 NGDDDMGTLL GLMHSAPPTE LQLKTDILRA LLSVLRESHR SRTVFRKVGG FVYITSLLVA 670 680 690 700 710 720 MERSLSCPPK NGWEKVNQNQ VFELLHTVFC TLTAAMRYEP ANSHFFKTEI QYEKLADAVR 730 740 750 760 770 780 FLGCFSDLRK ISAMNVFPSN TQPFQRLLEE DVISIESVSP TLRHCSKLFI YLYKVATDSF 790 800 810 820 830 840 DSRAEQIPPC LTSESSLPSP WGTPALSRKR HAYHSVSTPP VYPPKNVADL KLHVTTSSLQ 850 860 870 880 890 900 SSDAVIIHPG AMLAMLDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL 910 920 930 940 950 960 HARLLQRCSA ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLASPL NCGAWDKKLL 970 980 990 1000 1010 1020 KQYRVHKPSS LSYEPEMRSS MITSLEGLGT DNVFSLHEDN HYRISKSLVK SAEGSTVPLT 1030 1040 1050 1060 1070 1080 RVKCLVSMTT PHDIRLHGSS VTPAFVEFDT SLEGFGCLFL PSLAPHNAPT NNTVTTGLID 1090 1100 1110 1120 1130 1140 GAVVSGIGSG ERFFPPPSGL SYSSWFCIEH FSSPPNNHPV RLLTVVRRAN SSEQHYVCLA 1150 1160 1170 1180 1190 1200 IVLSAKDRSL IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELIIE GQWHHLVLVM 1210 1220 1230 1240 1250 1260 SKGMLKNSTA ALYIDGQLVN TVKLHYVHST PGGSGSANPP VVSTVYAYIG TPPAQRQIAS 1270 1280 1290 1300 1310 1320 LVWRLGPTHF LEEVLPSSNV TTIYELGPNY VGSFQAVCMP CKDAKSEGVV PSPVSLVPEE 1330 1340 1350 1360 1370 1380 KVSFGLYALS VSSLTVARIR KVYNKLDSKA IAKQLGISSH ENATPVKLIH NSAGHLNGSA 1390 1400 1410 1420 1430 1440 RTIGAALIGY LGVRTFVPKP VATTLQYVGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS 1450 1460 1470 1480 1490 1500 NPLASKEMER IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD 1510 1520 1530 1540 1550 1560 LLCDFEVWLH APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL LTLRDMSLSQ 1570 1580 1590 1600 1610 1620 PTIAAISNVL SFLLQGFPSS NDLLRFGQFI SSTLPTFAVC EKFVVMEINN EEKLDTGTEE 1630 1640 1650 1660 1670 1680 EFGGLVSANL ILLRNRLLDI LLKLIYTSKE KTSINLQACE ELVKTLGFDW IMMFMEEHLH 1690 1700 1710 1720 1730 1740 STTVTAAMRI LVVLLSNQSI LIKFKEGLSG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR 1750 1760 1770 1780 1790 1800 STVREINRDA CHFPGFPVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVIS 1810 1820 1830 1840 1850 1860 CRSKQGCQFD LDSIWTFIFG VPASSGTVVS SIHNVCTEAV FLLLGMLRSM LTSPWQSEEE 1870 1880 1890 1900 1910 1920 GSWLREYPVT LMQFFRYLYH NVPDLASMWM SPDFLCALAA TVFPFNIRPY SEMVTDLDDE 1930 1940 1950 1960 1970 1980 VGSPAEEFKA FAADTGMNRS QSEYCNVGTK TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS 1990 2000 2010 2020 2030 2040 KQTPLIDLLL EASPERSTRT QQKEFQTYIL DSVMDHLLAA DVLLGEDASL PITSGGSYQV 2050 2060 2070 2080 2090 2100 LVNNVFYFTQ RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL 2110 2120 2130 2140 2150 2160 YQFSRAHKTV PQQVALLDSL RVLTVNRNLI LGPGNHDQEF ISCLAHCLIN LHVGSNVDGF 2170 2180 2190 2200 2210 2220 GLEAEARMTT WHIMIPSDIE PDGSYSQDIS EGRQLLIKAV NRVWTELIHS KKQVLEELFK 2230 2240 2250 2260 2270 2280 VTLPVNERGH VDIATARPLI EEAALKCWQN HLAHEKKCIS RGEALAPTTQ SKLSRVSSGF 2290 2300 2310 2320 2330 2340 GLSKLTGSRR NRKESGLNKH SLSTQEISQW MFTHIAVVRD LVDTQYKEYQ ERQQNALKYV 2350 2360 2370 2380 2390 2400 TEEWCQIECE LLRERGLWGP PIGSHLDKWM LEMTEGPCRM RKKMVRNDMF YNHYPYVPET 2410 2420 2430 2440 2450 2460 EQETNVASEI PSKQPETPDD IPQKKPARYR RAVSYDSKEY YMRLASGNPA IVQDAIVESS 2470 2480 2490 2500 2510 2520 EGEAAQQEPE HGEDTIAKVK GLVKPPLKRS RSAPDGGDEE NQEQLQDQIA EGSSIEEEEK 2530 2540 2550 2560 2570 2580 TDNATLLRLL EEGEKIQHMY RCARVQGLDT SEGLLLFGKE HFYVIDGFTM TATREIRDIE 2590 2600 2610 2620 2630 2640 TLPPNMHEPI IPRGARQGPS QLKRTCSIFA YEDIKEVHKR RYLLQPIAVE VFSGDGRNYL 2650 2660 2670 2680 2690 2700 LAFQKGIRNK VYQRFLAVVP SLTDSSESVS GQRPNTSVEQ GSGLLSTLVG EKSVTQRWER 2710 2720 2730 2740 2750 2760 GEISNFQYLM HLNTLAGRSY NDLMQYPVFP WILADYDSEE VDLTNPKTFR NLAKPMGAQT 2770 2780 2790 2800 2810 2820 DERLAQYKKR YKDWEDPNGE TPAYHYGTHY SSAMIVASYL VRMEPFTQIF LRLQGGHFDL 2830 2840 2850 2860 2870 2880 ADRMFHSVRE AWYSASKHNM ADVKELIPEF FYLPEFLFNS NNFDLGCKQN GTKLGDVILP 2890 2900 2910 2920 2930 2940 PWAKGDPREF IRVHREALEC DYVSAHLHEW IDLIFGYKQQ GPAAVEAVNV FHHLFYEGQV 2950 2960 2970 2980 2990 3000 DIYNINDPLK ETATIGFINN FGQIPKQLFK KPHPPKRVRS RLNGDNAGIS VLPGSTSDKI 3010 3020 3030 3040 3050 3060 FFHHLDNLRP SLTPVKELKE PVGQIVCTDK GILAVEQNKV LIPPTWNKTF AWGYADLSCR 3070 3080 3090 3100 3110 3120 LGTYESDKAM TVYECLSEWG QILCAICPNP KLVITGGTST VVCVWEMGTS KEKAKTVTLK 3130 3140 3150 3160 3170 3180 QALLGHTDTV TCATASLAYH IIVSGSRDRT CIIWDLNKLS FLTQLRGHRA PVSALCINEL 3190 3200 3210 3220 3230 3240 TGDIVSCAGT YIHVWSINGN PIVSVNTFTG RSQQIICCCM SEMNEWDTQN VIVTGHSDGV 3250 3260 3270 3280 3290 3300 VRFWRMEFLQ VPETPAPEPA EVLEMQEDCP EAQIGQEAQD EDSSDSEADE QSISQDPKDT 3310 3320 3330 3340 3350 3360 PSQPSSTSHR PRAASCRATA AWCTDSGSDD SRRWSDQLSL DEKDGFIFVN YSEGQTRAHL 3370 3380 3390 3400 3410 3420 QGPLSHPHPN PIEVRNYSRL KPGYRWERQL VFRSKLTMHT AFDRKDNAHP AEVTALGISK 3430 3440 3450 3460 3470 3480 DHSRILVGDS RGRVFSWSVS DQPGRSAADH WVKDEGGDSC SGCSVRFSLT ERRHHCRNCG 3490 3500 3510 3520 QLFCQKCSRF QSEIKRLKIS SPVRVCQNCY YNLQHERGSE DGPRNC
	Isoform 2 [UniParc]. Checksum: 5DF8D0918CD685F6	FASTA	3,509	393,367
	10 20 30 40 50 60 MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR 70 80 90 100 110 120 VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEAASRAIVQ FLEINQSEEA 130 140 150 160 170 180 SRGWMLLTTI NLLASSGQKT VDCMTTMSVP STLVKCLYLF FDLPHVPEAV GGAQNELPLA 190 200 210 220 230 240 ERRGLLQKVF VQILVKLCSF VSPAEELAQK DDLQLLFSAI TSWCPPYNLP WRKSAGEVLM 250 260 270 280 290 300 TISRHGLSVN VVKYIHEKEC LSTCVQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL 310 320 330 340 350 360 LDDFRIWQGY NFLCDLLLRL EQAKEAESKD ALKDLVNLIT SLTTYGVSEL KPAGITTGAP 370 380 390 400 410 420 FLLPGFAVPQ PAGKGHSVRN VQAFAVLQNA FLKAKTSFLA QIILDAITNI YMADNANYFI 430 440 450 460 470 480 LESQHTLSQF AEKISKLPEV QNKYFEMLEF VVFSLNYIPC KELISVSILL KSSSSYHCSI 490 500 510 520 530 540 IAMKTLLKFT RHDYIFKDVF REVGLLEVMV NLLHKYAALL KDPTQALNEQ GDSRNNSSVE 550 560 570 580 590 600 DQKHLALLVM ETLTVLLQGS NTNAGIFREF GGARCAHNIV KYPQCRQHAL MTIQQLVLSP 610 620 630 640 650 660 NGDDDMGTLL GLMHSAPPTE LQLKTDILRA LLSVLRESHR SRTVFRKVGG FVYITSLLVA 670 680 690 700 710 720 MERSLSCPPK NGWEKVNQNQ VFELLHTVFC TLTAAMRYEP ANSHFFKTEI QYEKLADAVR 730 740 750 760 770 780 FLGCFSDLRK ISAMNVFPSN TQPFQRLLEE DVISIESVSP TLRHCSKLFI YLYKVATDSF 790 800 810 820 830 840 DSRAEQIPPC LTSESSLPSP WGTPALSRKR HAYHSVSTPP VYPPKNVADL KLHVTTSSLQ 850 860 870 880 890 900 SSDAVIIHPG AMLAMLDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL 910 920 930 940 950 960 HARLLQRCSA ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLASPL NCGAWDKKLL 970 980 990 1000 1010 1020 KQYRVHKPSS LSYEPEMRSS MITSLEGLGT DNVFSLHEDN HYRISKSLVK SAEGSTVPLT 1030 1040 1050 1060 1070 1080 RVKCLVSMTT PHDIRLHGSS VTPAFVEFDT SLEGFGCLFL PSLAPHNAPT NNTVTTGLID 1090 1100 1110 1120 1130 1140 GAVVSGIGSG ERFFPPPSGL SYSSWFCIEH FSSPPNNHPV RLLTVVRRAN SSEQHYVCLA 1150 1160 1170 1180 1190 1200 IVLSAKDRSL IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELIIE GQWHHLVLVM 1210 1220 1230 1240 1250 1260 SKGMLKNSTA ALYIDGQLVN TVKLHYVHST PGGSGSANPP VVSTVYAYIG TPPAQRQIAS 1270 1280 1290 1300 1310 1320 LVWRLGPTHF LEEVLPSSNV TTIYELGPNY VGSFQAVCMP CKDAKSEGVV PSPVSLVPEE 1330 1340 1350 1360 1370 1380 KVSFGLYALS VSSLTVARIR KVYNKLDSKA IAKQLGISSH ENATPVKLIH NSAGHLNGSA 1390 1400 1410 1420 1430 1440 RTIGAALIGY LGVRTFVPKP VATTLQYVGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS 1450 1460 1470 1480 1490 1500 NPLASKEMER IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD 1510 1520 1530 1540 1550 1560 LLCDFEVWLH APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL LTLRDMSLSQ 1570 1580 1590 1600 1610 1620 PTIAAISNVL SFLLQGFPSS NDLLRFGQFI SSTLPTFAVC EKFVVMEINN EEKLDTGTEE 1630 1640 1650 1660 1670 1680 EFGGLVSANL ILLRNRLLDI LLKLIYTSKE KTSINLQACE ELVKTLGFDW IMMFMEEHLH 1690 1700 1710 1720 1730 1740 STTVTAAMRI LVVLLSNQSI LIKFKEGLSG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR 1750 1760 1770 1780 1790 1800 STVREINRDA CHFPGFPVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVIS 1810 1820 1830 1840 1850 1860 CRSKQGCQFD LDSIWTFIFG VPASSGTVVS SIHNVCTEAV FLLLGMLRSM LTSPWQSEEE 1870 1880 1890 1900 1910 1920 GSWLREYPVT LMQFFRYLYH NVPDLASMWM SPDFLCALAA TVFPFNIRPY SEMVTDLDDE 1930 1940 1950 1960 1970 1980 VGSPAEEFKA FAADTGMNRS QSEYCNVGTK TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS 1990 2000 2010 2020 2030 2040 KQTPLIDLLL EASPERSTRT QQKEFQTYIL DSVMDHLLAA DVLLGEDASL PITSGGSYQV 2050 2060 2070 2080 2090 2100 LVNNVFYFTQ RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL 2110 2120 2130 2140 2150 2160 YQFSRAHKTV PQQVALLDSL RVLTVNRNLI LGPGNHDQEF ISCLAHCLIN LHVGSNVDGF 2170 2180 2190 2200 2210 2220 GLEAEARMTT WHIMIPSDIE PDGSYSQDIS EGRQLLIKAV NRVWTELIHS KKQVLEELFK 2230 2240 2250 2260 2270 2280 VTLPVNERGH VDIATARPLI EEAALKCWQN HLAHEKKCIS RGEALAPTTQ SKLSRVSSGF 2290 2300 2310 2320 2330 2340 GLSKLTGSRR NRKESGLNKH SLSTQEISQW MFTHIAVVRD LVDTQYKEYQ ERQQNALKYV 2350 2360 2370 2380 2390 2400 TEEWCQIECE LLRERGLWGP PIGSHLDKWM LEMTEGPCRM RKKMVRNDMF YNHYPYVPET 2410 2420 2430 2440 2450 2460 EQETNVAKPA RYRRAVSYDS KEYYMRLASG NPAIVQDAIV ESSEGEAAQQ EPEHGEDTIA 2470 2480 2490 2500 2510 2520 KVKGLVKPPL KRSRSAPDGG DEENQEQLQD QIAEGSSIEE EEKTDNATLL RLLEEGEKIQ 2530 2540 2550 2560 2570 2580 HMYRCARVQG LDTSEGLLLF GKEHFYVIDG FTMTATREIR DIETLPPNMH EPIIPRGARQ 2590 2600 2610 2620 2630 2640 GPSQLKRTCS IFAYEDIKEV HKRRYLLQPI AVEVFSGDGR NYLLAFQKGI RNKVYQRFLA 2650 2660 2670 2680 2690 2700 VVPSLTDSSE SVSGQRPNTS VEQGSGLLST LVGEKSVTQR WERGEISNFQ YLMHLNTLAG 2710 2720 2730 2740 2750 2760 RSYNDLMQYP VFPWILADYD SEEVDLTNPK TFRNLAKPMG AQTDERLAQY KKRYKDWEDP 2770 2780 2790 2800 2810 2820 NGETPAYHYG THYSSAMIVA SYLVRMEPFT QIFLRLQGGH FDLADRMFHS VREAWYSASK 2830 2840 2850 2860 2870 2880 HNMADVKELI PEFFYLPEFL FNSNNFDLGC KQNGTKLGDV ILPPWAKGDP REFIRVHREA 2890 2900 2910 2920 2930 2940 LECDYVSAHL HEWIDLIFGY KQQGPAAVEA VNVFHHLFYE GQVDIYNIND PLKETATIGF 2950 2960 2970 2980 2990 3000 INNFGQIPKQ LFKKPHPPKR VRSRLNGDNA GISVLPGSTS DKIFFHHLDN LRPSLTPVKE 3010 3020 3030 3040 3050 3060 LKEPVGQIVC TDKGILAVEQ NKVLIPPTWN KTFAWGYADL SCRLGTYESD KAMTVYECLS 3070 3080 3090 3100 3110 3120 EWGQILCAIC PNPKLVITGG TSTVVCVWEM GTSKEKAKTV TLKQALLGHT DTVTCATASL 3130 3140 3150 3160 3170 3180 AYHIIVSGSR DRTCIIWDLN KLSFLTQLRG HRAPVSALCI NELTGDIVSC AGTYIHVWSI 3190 3200 3210 3220 3230 3240 NGNPIVSVNT FTGRSQQIIC CCMSEMNEWD TQNVIVTGHS DGVVRFWRME FLQVPETPAP 3250 3260 3270 3280 3290 3300 EPAEVLEMQE DCPEAQIGQE AQDEDSSDSE ADEQSISQDP KDTPSQPSST SHRPRAASCR 3310 3320 3330 3340 3350 3360 ATAAWCTDSG SDDSRRWSDQ LSLDEKDGFI FVNYSEGQTR AHLQGPLSHP HPNPIEVRNY 3370 3380 3390 3400 3410 3420 SRLKPGYRWE RQLVFRSKLT MHTAFDRKDN AHPAEVTALG ISKDHSRILV GDSRGRVFSW 3430 3440 3450 3460 3470 3480 SVSDQPGRSA ADHWVKDEGG DSCSGCSVRF SLTERRHHCR NCGQLFCQKC SRFQSEIKRL 3490 3500 KISSPVRVCQ NCYYNLQHER GSEDGPRNC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes." Simonsen A., Birkeland H.C.G., Gillooly D.J., Mizushima N., Kuma A., Yoshimori T., Slagsvold T., Brech A., Stenmark H. J. Cell Sci. 117:4239-4251(2004) [PubMed: 15292400] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1971-3526 (ISOFORM 1). Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2381-3036 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2650-3526 (ISOFORM 1). Tissue: Corpus callosum and Kidney.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2749-3526 (ISOFORM 1). Tissue: Colon, Duodenum and Ovary.
[7]	"Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling." Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A., Lottspeich F., Chen Z. EMBO J. 25:5058-5070(2006) [PubMed: 17053785] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-653, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1696 AND SER-1699, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-813; SER-815; SER-817; THR-818 AND TYR-822, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF538685 mRNA. Translation: AAN15137.1. AC095046 Genomic DNA. Translation: AAY40903.1. AC104082 Genomic DNA. No translation available. AB023210 mRNA. Translation: BAA76837.2. AK055806 mRNA. Translation: BAB71020.1. Sequence problems. AK094910 mRNA. Translation: BAC04455.1. Different initiation. BC013377 mRNA. Translation: AAH13377.1. Different initiation. BC015214 mRNA. Translation: AAH15214.2. Different initiation. BC065502 mRNA. Translation: AAH65502.1. BC119633 mRNA. Translation: AAI19634.1.
IPI	IPI00218052. IPI00760714.
RefSeq	NP_055806.2. NM_014991.4.
UniGene	Hs.480116. Hs.726339.
3D structure databases
ProteinModelPortal	Q8IZQ1.
SMR	Q8IZQ1. Positions 2536-2976, 3043-3248, 3409-3439, 3448-3514.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZQ1. 8 interactions.
STRING	Q8IZQ1.
PTM databases
PhosphoSite	Q8IZQ1.
Polymorphism databases
DMDM	109896161.
Proteomic databases
PRIDE	Q8IZQ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295888; ENSP00000295888; ENSG00000163625.
GeneID	23001.
KEGG	hsa:23001.
UCSC	uc003hpd.1. human. uc003hpf.1. human.
Organism-specific databases
CTD	23001.
GeneCards	GC04M085590.
HGNC	HGNC:20751. WDFY3.
neXtProt	NX_Q8IZQ1.
PharmGKB	PA134903706.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12600.
HOVERGEN	HBG094156.
InParanoid	Q8IZQ1.
OMA	ETPAYHY.
OrthoDB	EOG408N73.
PhylomeDB	Q8IZQ1.
Gene expression databases
ArrayExpress	Q8IZQ1.
Bgee	Q8IZQ1.
CleanEx	HS_WDFY3.
Genevestigator	Q8IZQ1.
GermOnline	ENSG00000163625. Homo sapiens.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR000409. BEACH_dom. IPR008985. ConA-like_lec_gl. IPR013320. ConA-like_subgrp. IPR013763. Cyclin-like. IPR023362. PH-BEACH_dom. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 2 hits. G3DSA:1.10.1540.10. Beige_BEACH. 1 hit. G3DSA:2.60.120.200. ConA_like_subgrp. 1 hit. G3DSA:2.30.29.40. G3DSA:2.30.29.40. 1 hit. G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits. G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF02138. Beach. 1 hit. PF01363. FYVE. 1 hit. PF00400. WD40. 2 hits. [Graphical view]
SMART	SM01026. Beach. 1 hit. SM00064. FYVE. 1 hit. SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF81837. Beige_BEACH. 1 hit. SSF49899. ConA_like_lec_gl. 1 hit. SSF47954. Cyclin_like. 1 hit. SSF57903. FYVE_PHD_ZnF. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS50197. BEACH. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. PS50178. ZF_FYVE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	43900.

Entry information

Entry name

WDFY3_HUMAN

Accession

Primary (citable) accession number: Q8IZQ1
Secondary accession number(s): Q4W5K5 , Q6P0Q5, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.