SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IZQ1

- WDFY3_HUMAN

UniProt

Q8IZQ1 - WDFY3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

WD repeat and FYVE domain-containing protein 3

Gene
WDFY3, KIAA0993
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3454 – 351461FYVE-typeAdd
BLAST

GO - Molecular functioni

  1. 1-phosphatidylinositol binding Source: MGI
  2. beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity Source: Ensembl
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct

GO - Biological processi

  1. aggrephagy Source: UniProtKB
  2. positive regulation of macroautophagy Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ8IZQ1.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and FYVE domain-containing protein 3
Alternative name(s):
Autophagy-linked FYVE protein
Short name:
Alfy
Gene namesi
Name:WDFY3
Synonyms:KIAA0993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:20751. WDFY3.

Subcellular locationi

Nucleus membrane. Cytoplasm. NucleusPML body. Membrane; Peripheral membrane protein; Cytoplasmic side
Note: Colocalizes with autophagic structures in starved cells. Shuttles between nucleus and cytoplasm; translocation from the nucleus to cytoplasmic polyubiquitin-containing bodies upon cellular stress is dependent on SQSTM1.

GO - Cellular componenti

  1. autophagic vacuole Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. extrinsic component of membrane Source: MGI
  4. inclusion body Source: UniProtKB
  5. nuclear envelope Source: UniProtKB
  6. PML body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi3343 – 33431K → A: Decreases interaction with GABARAP and does not increase interaction with MAP1LC3B; when associated with A-3344 and A-3351.
Mutagenesisi3344 – 33441D → A: Decreases interaction with GABARAP and does not increase interaction with MAP1LC3B; when associated with A-3343 and A-3351.
Mutagenesisi3346 – 33461F → A: Abolishes interaction with GABARAP and MAP1LC3C.
Mutagenesisi3347 – 33471I → A: Decreases interaction with GABARAP and MAP1LC3C.
Mutagenesisi3348 – 33481F → A: Decreases interaction with GABARAP and MAP1LC3C.
Mutagenesisi3349 – 33491V → A: Decreases interaction with GABARAP and MAP1LC3C.
Mutagenesisi3351 – 33511Y → A: Decreases interaction with GABARAP and does not increase interaction with MAP1LC3B; when associated with A-3343 and A-3344.

Organism-specific databases

PharmGKBiPA134903706.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 35263526WD repeat and FYVE domain-containing protein 3PRO_0000242693Add
BLAST

Proteomic databases

MaxQBiQ8IZQ1.
PaxDbiQ8IZQ1.
PRIDEiQ8IZQ1.

PTM databases

PhosphoSiteiQ8IZQ1.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in osteoclast and their mononuclear precursors (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ8IZQ1.
BgeeiQ8IZQ1.
CleanExiHS_WDFY3.
GenevestigatoriQ8IZQ1.

Organism-specific databases

HPAiHPA042734.
HPA048572.

Interactioni

Subunit structurei

Interacts with ATG5 and SQSTM1. Associates with the ATG12-ATG5-ATG16L complex. Interacts with GABARAP, GABARAPL1 and GABARAPL2, and weakly with MAP1LC3C.

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG5Q9H1Y07EBI-1569256,EBI-1047414
HTTP4285810EBI-1569256,EBI-466029

Protein-protein interaction databases

BioGridi116647. 12 interactions.
IntActiQ8IZQ1. 14 interactions.
MINTiMINT-4829131.

Structurei

Secondary structure

1
3526
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3346 – 33483

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WIMX-ray2.60B3341-3354[»]
ProteinModelPortaliQ8IZQ1.
SMRiQ8IZQ1. Positions 2611-2976, 3047-3245, 3409-3441, 3448-3513.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2683 – 2976294BEACHAdd
BLAST
Repeati3077 – 311539WD 1Add
BLAST
Repeati3125 – 316440WD 2Add
BLAST
Repeati3167 – 320640WD 3Add
BLAST
Repeati3210 – 325445WD 4Add
BLAST
Repeati3408 – 344740WD 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2285 – 2981697Sufficient for translocalization to p62 bodies/ALISAdd
BLAST
Regioni2586 – 3526941Interaction with SQSTM1Add
BLAST
Regioni2981 – 3526546Interaction with ATG5Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi3344 – 33496LIR

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi472 – 4754Poly-Ser
Compositional biasi2516 – 25194Poly-Glu

Domaini

The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.

Sequence similaritiesi

Contains 1 BEACH domain.
Contains 5 WD repeats.

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG236271.
HOVERGENiHBG094156.
InParanoidiQ8IZQ1.
OMAiQEEKLYM.
OrthoDBiEOG70CR5S.
PhylomeDBiQ8IZQ1.
TreeFamiTF313658.

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
1.25.10.10. 2 hits.
2.130.10.10. 2 hits.
2.30.29.40. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF01363. FYVE. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00064. FYVE. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF57903. SSF57903. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZQ1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK     50
LYMMLPVFNR VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS 100
TEAASRAIVQ FLEINQSEEA SRGWMLLTTI NLLASSGQKT VDCMTTMSVP 150
STLVKCLYLF FDLPHVPEAV GGAQNELPLA ERRGLLQKVF VQILVKLCSF 200
VSPAEELAQK DDLQLLFSAI TSWCPPYNLP WRKSAGEVLM TISRHGLSVN 250
VVKYIHEKEC LSTCVQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL 300
LDDFRIWQGY NFLCDLLLRL EQAKEAESKD ALKDLVNLIT SLTTYGVSEL 350
KPAGITTGAP FLLPGFAVPQ PAGKGHSVRN VQAFAVLQNA FLKAKTSFLA 400
QIILDAITNI YMADNANYFI LESQHTLSQF AEKISKLPEV QNKYFEMLEF 450
VVFSLNYIPC KELISVSILL KSSSSYHCSI IAMKTLLKFT RHDYIFKDVF 500
REVGLLEVMV NLLHKYAALL KDPTQALNEQ GDSRNNSSVE DQKHLALLVM 550
ETLTVLLQGS NTNAGIFREF GGARCAHNIV KYPQCRQHAL MTIQQLVLSP 600
NGDDDMGTLL GLMHSAPPTE LQLKTDILRA LLSVLRESHR SRTVFRKVGG 650
FVYITSLLVA MERSLSCPPK NGWEKVNQNQ VFELLHTVFC TLTAAMRYEP 700
ANSHFFKTEI QYEKLADAVR FLGCFSDLRK ISAMNVFPSN TQPFQRLLEE 750
DVISIESVSP TLRHCSKLFI YLYKVATDSF DSRAEQIPPC LTSESSLPSP 800
WGTPALSRKR HAYHSVSTPP VYPPKNVADL KLHVTTSSLQ SSDAVIIHPG 850
AMLAMLDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL 900
HARLLQRCSA ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLASPL 950
NCGAWDKKLL KQYRVHKPSS LSYEPEMRSS MITSLEGLGT DNVFSLHEDN 1000
HYRISKSLVK SAEGSTVPLT RVKCLVSMTT PHDIRLHGSS VTPAFVEFDT 1050
SLEGFGCLFL PSLAPHNAPT NNTVTTGLID GAVVSGIGSG ERFFPPPSGL 1100
SYSSWFCIEH FSSPPNNHPV RLLTVVRRAN SSEQHYVCLA IVLSAKDRSL 1150
IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELIIE GQWHHLVLVM 1200
SKGMLKNSTA ALYIDGQLVN TVKLHYVHST PGGSGSANPP VVSTVYAYIG 1250
TPPAQRQIAS LVWRLGPTHF LEEVLPSSNV TTIYELGPNY VGSFQAVCMP 1300
CKDAKSEGVV PSPVSLVPEE KVSFGLYALS VSSLTVARIR KVYNKLDSKA 1350
IAKQLGISSH ENATPVKLIH NSAGHLNGSA RTIGAALIGY LGVRTFVPKP 1400
VATTLQYVGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS NPLASKEMER 1450
IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD 1500
LLCDFEVWLH APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL 1550
LTLRDMSLSQ PTIAAISNVL SFLLQGFPSS NDLLRFGQFI SSTLPTFAVC 1600
EKFVVMEINN EEKLDTGTEE EFGGLVSANL ILLRNRLLDI LLKLIYTSKE 1650
KTSINLQACE ELVKTLGFDW IMMFMEEHLH STTVTAAMRI LVVLLSNQSI 1700
LIKFKEGLSG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR STVREINRDA 1750
CHFPGFPVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVIS 1800
CRSKQGCQFD LDSIWTFIFG VPASSGTVVS SIHNVCTEAV FLLLGMLRSM 1850
LTSPWQSEEE GSWLREYPVT LMQFFRYLYH NVPDLASMWM SPDFLCALAA 1900
TVFPFNIRPY SEMVTDLDDE VGSPAEEFKA FAADTGMNRS QSEYCNVGTK 1950
TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS KQTPLIDLLL EASPERSTRT 2000
QQKEFQTYIL DSVMDHLLAA DVLLGEDASL PITSGGSYQV LVNNVFYFTQ 2050
RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL 2100
YQFSRAHKTV PQQVALLDSL RVLTVNRNLI LGPGNHDQEF ISCLAHCLIN 2150
LHVGSNVDGF GLEAEARMTT WHIMIPSDIE PDGSYSQDIS EGRQLLIKAV 2200
NRVWTELIHS KKQVLEELFK VTLPVNERGH VDIATARPLI EEAALKCWQN 2250
HLAHEKKCIS RGEALAPTTQ SKLSRVSSGF GLSKLTGSRR NRKESGLNKH 2300
SLSTQEISQW MFTHIAVVRD LVDTQYKEYQ ERQQNALKYV TEEWCQIECE 2350
LLRERGLWGP PIGSHLDKWM LEMTEGPCRM RKKMVRNDMF YNHYPYVPET 2400
EQETNVASEI PSKQPETPDD IPQKKPARYR RAVSYDSKEY YMRLASGNPA 2450
IVQDAIVESS EGEAAQQEPE HGEDTIAKVK GLVKPPLKRS RSAPDGGDEE 2500
NQEQLQDQIA EGSSIEEEEK TDNATLLRLL EEGEKIQHMY RCARVQGLDT 2550
SEGLLLFGKE HFYVIDGFTM TATREIRDIE TLPPNMHEPI IPRGARQGPS 2600
QLKRTCSIFA YEDIKEVHKR RYLLQPIAVE VFSGDGRNYL LAFQKGIRNK 2650
VYQRFLAVVP SLTDSSESVS GQRPNTSVEQ GSGLLSTLVG EKSVTQRWER 2700
GEISNFQYLM HLNTLAGRSY NDLMQYPVFP WILADYDSEE VDLTNPKTFR 2750
NLAKPMGAQT DERLAQYKKR YKDWEDPNGE TPAYHYGTHY SSAMIVASYL 2800
VRMEPFTQIF LRLQGGHFDL ADRMFHSVRE AWYSASKHNM ADVKELIPEF 2850
FYLPEFLFNS NNFDLGCKQN GTKLGDVILP PWAKGDPREF IRVHREALEC 2900
DYVSAHLHEW IDLIFGYKQQ GPAAVEAVNV FHHLFYEGQV DIYNINDPLK 2950
ETATIGFINN FGQIPKQLFK KPHPPKRVRS RLNGDNAGIS VLPGSTSDKI 3000
FFHHLDNLRP SLTPVKELKE PVGQIVCTDK GILAVEQNKV LIPPTWNKTF 3050
AWGYADLSCR LGTYESDKAM TVYECLSEWG QILCAICPNP KLVITGGTST 3100
VVCVWEMGTS KEKAKTVTLK QALLGHTDTV TCATASLAYH IIVSGSRDRT 3150
CIIWDLNKLS FLTQLRGHRA PVSALCINEL TGDIVSCAGT YIHVWSINGN 3200
PIVSVNTFTG RSQQIICCCM SEMNEWDTQN VIVTGHSDGV VRFWRMEFLQ 3250
VPETPAPEPA EVLEMQEDCP EAQIGQEAQD EDSSDSEADE QSISQDPKDT 3300
PSQPSSTSHR PRAASCRATA AWCTDSGSDD SRRWSDQLSL DEKDGFIFVN 3350
YSEGQTRAHL QGPLSHPHPN PIEVRNYSRL KPGYRWERQL VFRSKLTMHT 3400
AFDRKDNAHP AEVTALGISK DHSRILVGDS RGRVFSWSVS DQPGRSAADH 3450
WVKDEGGDSC SGCSVRFSLT ERRHHCRNCG QLFCQKCSRF QSEIKRLKIS 3500
SPVRVCQNCY YNLQHERGSE DGPRNC 3526
Length:3,526
Mass (Da):395,258
Last modified:June 27, 2006 - v2
Checksum:iF4D518E8C9C12E23
GO
Isoform 2 (identifier: Q8IZQ1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2408-2424: Missing.

Show »
Length:3,509
Mass (Da):393,367
Checksum:i5DF8D0918CD685F6
GO

Sequence cautioni

The sequence BAB71020.1 differs from that shown. Reason: Aberrant splicing.
The sequence AAH13377.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH15214.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAC04455.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3032 – 30321I → V.
Corresponds to variant rs17368018 [ dbSNP | Ensembl ].
VAR_026864

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2408 – 242417Missing in isoform 2. VSP_019475Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2944 – 29441N → T in AAN15137. 1 Publication
Sequence conflicti3396 – 33961L → P in BAB71020. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF538685 mRNA. Translation: AAN15137.1.
AC095046 Genomic DNA. Translation: AAY40903.1.
AC104082 Genomic DNA. No translation available.
AB023210 mRNA. Translation: BAA76837.2.
AK055806 mRNA. Translation: BAB71020.1. Sequence problems.
AK094910 mRNA. Translation: BAC04455.1. Different initiation.
BC013377 mRNA. Translation: AAH13377.1. Different initiation.
BC015214 mRNA. Translation: AAH15214.2. Different initiation.
BC065502 mRNA. Translation: AAH65502.1.
BC119633 mRNA. Translation: AAI19634.1.
CCDSiCCDS3609.1. [Q8IZQ1-1]
RefSeqiNP_055806.2. NM_014991.4. [Q8IZQ1-1]
UniGeneiHs.480116.
Hs.726339.

Genome annotation databases

EnsembliENST00000295888; ENSP00000295888; ENSG00000163625. [Q8IZQ1-1]
ENST00000322366; ENSP00000318466; ENSG00000163625. [Q8IZQ1-2]
GeneIDi23001.
KEGGihsa:23001.
UCSCiuc003hpd.3. human. [Q8IZQ1-1]

Polymorphism databases

DMDMi109896161.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF538685 mRNA. Translation: AAN15137.1 .
AC095046 Genomic DNA. Translation: AAY40903.1 .
AC104082 Genomic DNA. No translation available.
AB023210 mRNA. Translation: BAA76837.2 .
AK055806 mRNA. Translation: BAB71020.1 . Sequence problems.
AK094910 mRNA. Translation: BAC04455.1 . Different initiation.
BC013377 mRNA. Translation: AAH13377.1 . Different initiation.
BC015214 mRNA. Translation: AAH15214.2 . Different initiation.
BC065502 mRNA. Translation: AAH65502.1 .
BC119633 mRNA. Translation: AAI19634.1 .
CCDSi CCDS3609.1. [Q8IZQ1-1 ]
RefSeqi NP_055806.2. NM_014991.4. [Q8IZQ1-1 ]
UniGenei Hs.480116.
Hs.726339.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3WIM X-ray 2.60 B 3341-3354 [» ]
ProteinModelPortali Q8IZQ1.
SMRi Q8IZQ1. Positions 2611-2976, 3047-3245, 3409-3441, 3448-3513.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116647. 12 interactions.
IntActi Q8IZQ1. 14 interactions.
MINTi MINT-4829131.

PTM databases

PhosphoSitei Q8IZQ1.

Polymorphism databases

DMDMi 109896161.

Proteomic databases

MaxQBi Q8IZQ1.
PaxDbi Q8IZQ1.
PRIDEi Q8IZQ1.

Protocols and materials databases

DNASUi 23001.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295888 ; ENSP00000295888 ; ENSG00000163625 . [Q8IZQ1-1 ]
ENST00000322366 ; ENSP00000318466 ; ENSG00000163625 . [Q8IZQ1-2 ]
GeneIDi 23001.
KEGGi hsa:23001.
UCSCi uc003hpd.3. human. [Q8IZQ1-1 ]

Organism-specific databases

CTDi 23001.
GeneCardsi GC04M085590.
H-InvDB HIX0004348.
HGNCi HGNC:20751. WDFY3.
HPAi HPA042734.
HPA048572.
neXtProti NX_Q8IZQ1.
PharmGKBi PA134903706.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236271.
HOVERGENi HBG094156.
InParanoidi Q8IZQ1.
OMAi QEEKLYM.
OrthoDBi EOG70CR5S.
PhylomeDBi Q8IZQ1.
TreeFami TF313658.

Enzyme and pathway databases

SignaLinki Q8IZQ1.

Miscellaneous databases

ChiTaRSi WDFY3. human.
GeneWikii WDFY3.
GenomeRNAii 23001.
NextBioi 43900.
PROi Q8IZQ1.

Gene expression databases

ArrayExpressi Q8IZQ1.
Bgeei Q8IZQ1.
CleanExi HS_WDFY3.
Genevestigatori Q8IZQ1.

Family and domain databases

Gene3Di 1.10.1540.10. 1 hit.
1.25.10.10. 2 hits.
2.130.10.10. 2 hits.
2.30.29.40. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF02138. Beach. 1 hit.
PF01363. FYVE. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM01026. Beach. 1 hit.
SM00064. FYVE. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
SSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF57903. SSF57903. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEi PS50197. BEACH. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes."
    Simonsen A., Birkeland H.C.G., Gillooly D.J., Mizushima N., Kuma A., Yoshimori T., Slagsvold T., Brech A., Stenmark H.
    J. Cell Sci. 117:4239-4251(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1971-3526 (ISOFORM 1).
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2381-3036 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2650-3526 (ISOFORM 1).
    Tissue: Corpus callosum and Kidney.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2749-3526 (ISOFORM 1).
    Tissue: Colon, Duodenum and Ovary.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy."
    Clausen T.H., Lamark T., Isakson P., Finley K., Larsen K.B., Brech A., Overvatn A., Stenmark H., Bjorkoy G., Simonsen A., Johansen T.
    Autophagy 6:330-344(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SQSTM1, SUBCELLULAR LOCATION.
  9. "Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts."
    Hocking L.J., Mellis D.J., McCabe P.S., Helfrich M.H., Rogers M.J.
    Biochem. Biophys. Res. Commun. 402:543-548(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SQSTM1, TISSUE SPECIFICITY.
  10. "The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy."
    Filimonenko M., Isakson P., Finley K.D., Anderson M., Jeong H., Melia T.J., Bartlett B.J., Myers K.M., Birkeland H.C., Lamark T., Krainc D., Brech A., Stenmark H., Simonsen A., Yamamoto A.
    Mol. Cell 38:265-279(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ATG5, ASSOCIATION WITH THE ATG12-ATG5-ATG16L COMPLEX, SUBCELLULAR LOCATION.
  11. "Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures."
    Lystad A.H., Ichimura Y., Takagi K., Yang Y., Pankiv S., Kanegae Y., Kageyama S., Suzuki M., Saito I., Mizushima T., Komatsu M., Simonsen A.
    EMBO Rep. 15:557-565(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 3341-3354 IN COMPLEX WITH GABARAP, INTERACTION WITH MAP1LC3C; GABARAPL1 AND GABARAPL2, LIR MOTIF, MUTAGENESIS OF LYS-3343; ASP-3344; PHE-3346; ILE-3347; PHE-3348; VAL-3349 AND TYR-3351.

Entry informationi

Entry nameiWDFY3_HUMAN
AccessioniPrimary (citable) accession number: Q8IZQ1
Secondary accession number(s): Q4W5K5
, Q6P0Q5, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi