Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8IZQ1 (WDFY3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat and FYVE domain-containing protein 3
Alternative name(s):
Autophagy-linked FYVE protein
Short name=Alfy
Gene names
Name:WDFY3
Synonyms:KIAA0993
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length3526 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Peripheral membrane protein; Cytoplasmic side. Note: Colocalizes with autophagic structures in starved cells. Ref.1

Tissue specificity

Ubiquitous. Ref.1

Sequence similarities

Contains 1 BEACH domain.

Contains 1 FYVE-type zinc finger.

Contains 5 WD repeats.

Sequence caution

The sequence AAH13377.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH15214.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAB71020.1 differs from that shown. Reason: Aberrant splicing.

The sequence BAC04455.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IZQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IZQ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2408-2424: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 35263526WD repeat and FYVE domain-containing protein 3
PRO_0000242693

Regions

Domain2683 – 2976294BEACH
Repeat3077 – 311539WD 1
Repeat3125 – 316440WD 2
Repeat3167 – 320640WD 3
Repeat3210 – 325445WD 4
Repeat3408 – 344740WD 5
Zinc finger3454 – 351461FYVE-type
Compositional bias472 – 4754Poly-Ser
Compositional bias2516 – 25194Poly-Glu

Natural variations

Alternative sequence2408 – 242417Missing in isoform 2.
VSP_019475
Natural variant30321I → V.
Corresponds to variant rs17368018 [ dbSNP | Ensembl ].
VAR_026864

Experimental info

Sequence conflict29441N → T in AAN15137. Ref.1
Sequence conflict33961L → P in BAB71020. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: F4D518E8C9C12E23

FASTA3,526395,258
        10         20         30         40         50         60 
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR 

        70         80         90        100        110        120 
VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEAASRAIVQ FLEINQSEEA 

       130        140        150        160        170        180 
SRGWMLLTTI NLLASSGQKT VDCMTTMSVP STLVKCLYLF FDLPHVPEAV GGAQNELPLA 

       190        200        210        220        230        240 
ERRGLLQKVF VQILVKLCSF VSPAEELAQK DDLQLLFSAI TSWCPPYNLP WRKSAGEVLM 

       250        260        270        280        290        300 
TISRHGLSVN VVKYIHEKEC LSTCVQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL 

       310        320        330        340        350        360 
LDDFRIWQGY NFLCDLLLRL EQAKEAESKD ALKDLVNLIT SLTTYGVSEL KPAGITTGAP 

       370        380        390        400        410        420 
FLLPGFAVPQ PAGKGHSVRN VQAFAVLQNA FLKAKTSFLA QIILDAITNI YMADNANYFI 

       430        440        450        460        470        480 
LESQHTLSQF AEKISKLPEV QNKYFEMLEF VVFSLNYIPC KELISVSILL KSSSSYHCSI 

       490        500        510        520        530        540 
IAMKTLLKFT RHDYIFKDVF REVGLLEVMV NLLHKYAALL KDPTQALNEQ GDSRNNSSVE 

       550        560        570        580        590        600 
DQKHLALLVM ETLTVLLQGS NTNAGIFREF GGARCAHNIV KYPQCRQHAL MTIQQLVLSP 

       610        620        630        640        650        660 
NGDDDMGTLL GLMHSAPPTE LQLKTDILRA LLSVLRESHR SRTVFRKVGG FVYITSLLVA 

       670        680        690        700        710        720 
MERSLSCPPK NGWEKVNQNQ VFELLHTVFC TLTAAMRYEP ANSHFFKTEI QYEKLADAVR 

       730        740        750        760        770        780 
FLGCFSDLRK ISAMNVFPSN TQPFQRLLEE DVISIESVSP TLRHCSKLFI YLYKVATDSF 

       790        800        810        820        830        840 
DSRAEQIPPC LTSESSLPSP WGTPALSRKR HAYHSVSTPP VYPPKNVADL KLHVTTSSLQ 

       850        860        870        880        890        900 
SSDAVIIHPG AMLAMLDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL 

       910        920        930        940        950        960 
HARLLQRCSA ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLASPL NCGAWDKKLL 

       970        980        990       1000       1010       1020 
KQYRVHKPSS LSYEPEMRSS MITSLEGLGT DNVFSLHEDN HYRISKSLVK SAEGSTVPLT 

      1030       1040       1050       1060       1070       1080 
RVKCLVSMTT PHDIRLHGSS VTPAFVEFDT SLEGFGCLFL PSLAPHNAPT NNTVTTGLID 

      1090       1100       1110       1120       1130       1140 
GAVVSGIGSG ERFFPPPSGL SYSSWFCIEH FSSPPNNHPV RLLTVVRRAN SSEQHYVCLA 

      1150       1160       1170       1180       1190       1200 
IVLSAKDRSL IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELIIE GQWHHLVLVM 

      1210       1220       1230       1240       1250       1260 
SKGMLKNSTA ALYIDGQLVN TVKLHYVHST PGGSGSANPP VVSTVYAYIG TPPAQRQIAS 

      1270       1280       1290       1300       1310       1320 
LVWRLGPTHF LEEVLPSSNV TTIYELGPNY VGSFQAVCMP CKDAKSEGVV PSPVSLVPEE 

      1330       1340       1350       1360       1370       1380 
KVSFGLYALS VSSLTVARIR KVYNKLDSKA IAKQLGISSH ENATPVKLIH NSAGHLNGSA 

      1390       1400       1410       1420       1430       1440 
RTIGAALIGY LGVRTFVPKP VATTLQYVGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS 

      1450       1460       1470       1480       1490       1500 
NPLASKEMER IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD 

      1510       1520       1530       1540       1550       1560 
LLCDFEVWLH APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL LTLRDMSLSQ 

      1570       1580       1590       1600       1610       1620 
PTIAAISNVL SFLLQGFPSS NDLLRFGQFI SSTLPTFAVC EKFVVMEINN EEKLDTGTEE 

      1630       1640       1650       1660       1670       1680 
EFGGLVSANL ILLRNRLLDI LLKLIYTSKE KTSINLQACE ELVKTLGFDW IMMFMEEHLH 

      1690       1700       1710       1720       1730       1740 
STTVTAAMRI LVVLLSNQSI LIKFKEGLSG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR 

      1750       1760       1770       1780       1790       1800 
STVREINRDA CHFPGFPVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVIS 

      1810       1820       1830       1840       1850       1860 
CRSKQGCQFD LDSIWTFIFG VPASSGTVVS SIHNVCTEAV FLLLGMLRSM LTSPWQSEEE 

      1870       1880       1890       1900       1910       1920 
GSWLREYPVT LMQFFRYLYH NVPDLASMWM SPDFLCALAA TVFPFNIRPY SEMVTDLDDE 

      1930       1940       1950       1960       1970       1980 
VGSPAEEFKA FAADTGMNRS QSEYCNVGTK TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS 

      1990       2000       2010       2020       2030       2040 
KQTPLIDLLL EASPERSTRT QQKEFQTYIL DSVMDHLLAA DVLLGEDASL PITSGGSYQV 

      2050       2060       2070       2080       2090       2100 
LVNNVFYFTQ RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL 

      2110       2120       2130       2140       2150       2160 
YQFSRAHKTV PQQVALLDSL RVLTVNRNLI LGPGNHDQEF ISCLAHCLIN LHVGSNVDGF 

      2170       2180       2190       2200       2210       2220 
GLEAEARMTT WHIMIPSDIE PDGSYSQDIS EGRQLLIKAV NRVWTELIHS KKQVLEELFK 

      2230       2240       2250       2260       2270       2280 
VTLPVNERGH VDIATARPLI EEAALKCWQN HLAHEKKCIS RGEALAPTTQ SKLSRVSSGF 

      2290       2300       2310       2320       2330       2340 
GLSKLTGSRR NRKESGLNKH SLSTQEISQW MFTHIAVVRD LVDTQYKEYQ ERQQNALKYV 

      2350       2360       2370       2380       2390       2400 
TEEWCQIECE LLRERGLWGP PIGSHLDKWM LEMTEGPCRM RKKMVRNDMF YNHYPYVPET 

      2410       2420       2430       2440       2450       2460 
EQETNVASEI PSKQPETPDD IPQKKPARYR RAVSYDSKEY YMRLASGNPA IVQDAIVESS 

      2470       2480       2490       2500       2510       2520 
EGEAAQQEPE HGEDTIAKVK GLVKPPLKRS RSAPDGGDEE NQEQLQDQIA EGSSIEEEEK 

      2530       2540       2550       2560       2570       2580 
TDNATLLRLL EEGEKIQHMY RCARVQGLDT SEGLLLFGKE HFYVIDGFTM TATREIRDIE 

      2590       2600       2610       2620       2630       2640 
TLPPNMHEPI IPRGARQGPS QLKRTCSIFA YEDIKEVHKR RYLLQPIAVE VFSGDGRNYL 

      2650       2660       2670       2680       2690       2700 
LAFQKGIRNK VYQRFLAVVP SLTDSSESVS GQRPNTSVEQ GSGLLSTLVG EKSVTQRWER 

      2710       2720       2730       2740       2750       2760 
GEISNFQYLM HLNTLAGRSY NDLMQYPVFP WILADYDSEE VDLTNPKTFR NLAKPMGAQT 

      2770       2780       2790       2800       2810       2820 
DERLAQYKKR YKDWEDPNGE TPAYHYGTHY SSAMIVASYL VRMEPFTQIF LRLQGGHFDL 

      2830       2840       2850       2860       2870       2880 
ADRMFHSVRE AWYSASKHNM ADVKELIPEF FYLPEFLFNS NNFDLGCKQN GTKLGDVILP 

      2890       2900       2910       2920       2930       2940 
PWAKGDPREF IRVHREALEC DYVSAHLHEW IDLIFGYKQQ GPAAVEAVNV FHHLFYEGQV 

      2950       2960       2970       2980       2990       3000 
DIYNINDPLK ETATIGFINN FGQIPKQLFK KPHPPKRVRS RLNGDNAGIS VLPGSTSDKI 

      3010       3020       3030       3040       3050       3060 
FFHHLDNLRP SLTPVKELKE PVGQIVCTDK GILAVEQNKV LIPPTWNKTF AWGYADLSCR 

      3070       3080       3090       3100       3110       3120 
LGTYESDKAM TVYECLSEWG QILCAICPNP KLVITGGTST VVCVWEMGTS KEKAKTVTLK 

      3130       3140       3150       3160       3170       3180 
QALLGHTDTV TCATASLAYH IIVSGSRDRT CIIWDLNKLS FLTQLRGHRA PVSALCINEL 

      3190       3200       3210       3220       3230       3240 
TGDIVSCAGT YIHVWSINGN PIVSVNTFTG RSQQIICCCM SEMNEWDTQN VIVTGHSDGV 

      3250       3260       3270       3280       3290       3300 
VRFWRMEFLQ VPETPAPEPA EVLEMQEDCP EAQIGQEAQD EDSSDSEADE QSISQDPKDT 

      3310       3320       3330       3340       3350       3360 
PSQPSSTSHR PRAASCRATA AWCTDSGSDD SRRWSDQLSL DEKDGFIFVN YSEGQTRAHL 

      3370       3380       3390       3400       3410       3420 
QGPLSHPHPN PIEVRNYSRL KPGYRWERQL VFRSKLTMHT AFDRKDNAHP AEVTALGISK 

      3430       3440       3450       3460       3470       3480 
DHSRILVGDS RGRVFSWSVS DQPGRSAADH WVKDEGGDSC SGCSVRFSLT ERRHHCRNCG 

      3490       3500       3510       3520 
QLFCQKCSRF QSEIKRLKIS SPVRVCQNCY YNLQHERGSE DGPRNC 

« Hide

Isoform 2 [UniParc].

Checksum: 5DF8D0918CD685F6
Show »

FASTA3,509393,367

References

« Hide 'large scale' references
[1]"Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes."
Simonsen A., Birkeland H.C.G., Gillooly D.J., Mizushima N., Kuma A., Yoshimori T., Slagsvold T., Brech A., Stenmark H.
J. Cell Sci. 117:4239-4251(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1971-3526 (ISOFORM 1).
Tissue: Brain.
[4]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2381-3036 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2650-3526 (ISOFORM 1).
Tissue: Corpus callosum and Kidney.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2749-3526 (ISOFORM 1).
Tissue: Colon, Duodenum and Ovary.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF538685 mRNA. Translation: AAN15137.1.
AC095046 Genomic DNA. Translation: AAY40903.1.
AC104082 Genomic DNA. No translation available.
AB023210 mRNA. Translation: BAA76837.2.
AK055806 mRNA. Translation: BAB71020.1. Sequence problems.
AK094910 mRNA. Translation: BAC04455.1. Different initiation.
BC013377 mRNA. Translation: AAH13377.1. Different initiation.
BC015214 mRNA. Translation: AAH15214.2. Different initiation.
BC065502 mRNA. Translation: AAH65502.1.
BC119633 mRNA. Translation: AAI19634.1.
RefSeqNP_055806.2. NM_014991.4.
UniGeneHs.480116.
Hs.726339.

3D structure databases

ProteinModelPortalQ8IZQ1.
SMRQ8IZQ1. Positions 2536-2976, 3047-3245, 3409-3439, 3448-3513.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116647. 12 interactions.
IntActQ8IZQ1. 14 interactions.
MINTMINT-4829131.

PTM databases

PhosphoSiteQ8IZQ1.

Polymorphism databases

DMDM109896161.

Proteomic databases

PaxDbQ8IZQ1.
PRIDEQ8IZQ1.

Protocols and materials databases

DNASU23001.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295888; ENSP00000295888; ENSG00000163625. [Q8IZQ1-1]
ENST00000322366; ENSP00000318466; ENSG00000163625. [Q8IZQ1-2]
GeneID23001.
KEGGhsa:23001.
UCSCuc003hpd.3. human. [Q8IZQ1-1]

Organism-specific databases

CTD23001.
GeneCardsGC04M085590.
H-InvDBHIX0004348.
HGNCHGNC:20751. WDFY3.
HPAHPA042734.
HPA048572.
neXtProtNX_Q8IZQ1.
PharmGKBPA134903706.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG236271.
HOVERGENHBG094156.
InParanoidQ8IZQ1.
OMAVDSGHET.
OrthoDBEOG70CR5S.
PhylomeDBQ8IZQ1.
TreeFamTF313658.

Enzyme and pathway databases

SignaLinkQ8IZQ1.

Gene expression databases

ArrayExpressQ8IZQ1.
BgeeQ8IZQ1.
CleanExHS_WDFY3.
GenevestigatorQ8IZQ1.

Family and domain databases

Gene3D1.10.1540.10. 1 hit.
1.25.10.10. 2 hits.
2.130.10.10. 2 hits.
2.30.29.40. 1 hit.
3.30.40.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF02138. Beach. 1 hit.
PF01363. FYVE. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTSM01026. Beach. 1 hit.
SM00064. FYVE. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 3 hits.
SSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF57903. SSF57903. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEPS50197. BEACH. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSWDFY3. human.
GeneWikiWDFY3.
GenomeRNAi23001.
NextBio43900.
PROQ8IZQ1.

Entry information

Entry nameWDFY3_HUMAN
AccessionPrimary (citable) accession number: Q8IZQ1
Secondary accession number(s): Q4W5K5 expand/collapse secondary AC list , Q6P0Q5, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM