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Protein

WD repeat and FYVE domain-containing protein 3

Gene

WDFY3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3454 – 3514FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

  • aggrephagy Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Autophagy

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ8IZQ1.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and FYVE domain-containing protein 3
Alternative name(s):
Autophagy-linked FYVE protein
Short name:
Alfy
Gene namesi
Name:WDFY3
Synonyms:KIAA0993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:20751. WDFY3.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • extrinsic component of autophagosome membrane Source: Ensembl
  • extrinsic component of membrane Source: MGI
  • inclusion body Source: UniProtKB
  • nuclear envelope Source: UniProtKB
  • nuclear membrane Source: UniProtKB-SubCell
  • PML body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi3343K → A: Decreases interaction with GABARAP and does not increase interaction with MAP1LC3B; when associated with A-3344 and A-3351. 1 Publication1
Mutagenesisi3344D → A: Decreases interaction with GABARAP and does not increase interaction with MAP1LC3B; when associated with A-3343 and A-3351. 1 Publication1
Mutagenesisi3346F → A: Abolishes interaction with GABARAP and MAP1LC3C. 1 Publication1
Mutagenesisi3347I → A: Decreases interaction with GABARAP and MAP1LC3C. 1 Publication1
Mutagenesisi3348F → A: Decreases interaction with GABARAP and MAP1LC3C. 1 Publication1
Mutagenesisi3349V → A: Decreases interaction with GABARAP and MAP1LC3C. 1 Publication1
Mutagenesisi3351Y → A: Decreases interaction with GABARAP and does not increase interaction with MAP1LC3B; when associated with A-3343 and A-3344. 1 Publication1

Organism-specific databases

DisGeNETi23001.
OpenTargetsiENSG00000163625.
PharmGKBiPA134903706.

Polymorphism and mutation databases

BioMutaiWDFY3.
DMDMi109896161.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426931 – 3526WD repeat and FYVE domain-containing protein 3Add BLAST3526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1942PhosphoserineBy similarity1
Modified residuei2278PhosphoserineCombined sources1
Modified residuei2492PhosphoserineBy similarity1
Modified residuei3335PhosphoserineBy similarity1
Modified residuei3339PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IZQ1.
MaxQBiQ8IZQ1.
PaxDbiQ8IZQ1.
PeptideAtlasiQ8IZQ1.
PRIDEiQ8IZQ1.

PTM databases

iPTMnetiQ8IZQ1.
PhosphoSitePlusiQ8IZQ1.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in osteoclast and their mononuclear precursors (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000163625.
CleanExiHS_WDFY3.
ExpressionAtlasiQ8IZQ1. baseline and differential.
GenevisibleiQ8IZQ1. HS.

Organism-specific databases

HPAiHPA042734.
HPA048572.

Interactioni

Subunit structurei

Interacts with ATG5 and SQSTM1. Associates with the ATG12-ATG5-ATG16L complex. Interacts with GABARAP, GABARAPL1 and GABARAPL2, and weakly with MAP1LC3C.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG5Q9H1Y07EBI-1569256,EBI-1047414
CEP76Q8TAP63EBI-10264625,EBI-742887
GABARAPQ6IAW117EBI-1569256,EBI-10106927
GABARAPL1Q9H0R83EBI-1569256,EBI-746969
GABARAPL2P605203EBI-1569256,EBI-720116
HTTP4285810EBI-1569256,EBI-466029
MAP1LC3BQ9GZQ86EBI-1569256,EBI-373144
MAP1LC3CQ9BXW47EBI-1569256,EBI-2603996
PIK3R3Q925692EBI-1569256,EBI-79893
taxP140793EBI-1569256,EBI-9675698From a different organism.
TRIM39Q9HCM93EBI-10264625,EBI-739510
ZBTB44Q8NCP53EBI-10264625,EBI-5658292

Protein-protein interaction databases

BioGridi116647. 62 interactors.
IntActiQ8IZQ1. 43 interactors.
MINTiMINT-4829131.
STRINGi9606.ENSP00000295888.

Structurei

Secondary structure

13526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3346 – 3348Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WIMX-ray2.60B3341-3354[»]
ProteinModelPortaliQ8IZQ1.
SMRiQ8IZQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2531 – 2656BEACH-type PHPROSITE-ProRule annotationAdd BLAST126
Domaini2683 – 2976BEACHPROSITE-ProRule annotationAdd BLAST294
Repeati3077 – 3115WD 1Add BLAST39
Repeati3125 – 3164WD 2Add BLAST40
Repeati3167 – 3206WD 3Add BLAST40
Repeati3210 – 3254WD 4Add BLAST45
Repeati3408 – 3447WD 5Add BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2285 – 2981Sufficient for translocalization to p62 bodies/ALISAdd BLAST697
Regioni2586 – 3526Interaction with SQSTM1Add BLAST941
Regioni2981 – 3526Interaction with ATG51 PublicationAdd BLAST546

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi3344 – 3349LIR6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi472 – 475Poly-Ser4
Compositional biasi2516 – 2519Poly-Glu4

Domaini

The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.

Sequence similaritiesi

Contains 1 BEACH domain.PROSITE-ProRule annotation
Contains 1 BEACH-type PH domain.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3454 – 3514FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1786. Eukaryota.
KOG1788. Eukaryota.
ENOG410XNQC. LUCA.
GeneTreeiENSGT00760000119083.
HOVERGENiHBG094156.
InParanoidiQ8IZQ1.
OMAiGPTHFLE.
OrthoDBiEOG091G002Q.
PhylomeDBiQ8IZQ1.
TreeFamiTF313658.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
1.25.10.10. 2 hits.
2.130.10.10. 2 hits.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF15787. DUF4704. 1 hit.
PF01363. FYVE. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00064. FYVE. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF57903. SSF57903. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK
60 70 80 90 100
LYMMLPVFNR VFGNAPPNTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS
110 120 130 140 150
TEAASRAIVQ FLEINQSEEA SRGWMLLTTI NLLASSGQKT VDCMTTMSVP
160 170 180 190 200
STLVKCLYLF FDLPHVPEAV GGAQNELPLA ERRGLLQKVF VQILVKLCSF
210 220 230 240 250
VSPAEELAQK DDLQLLFSAI TSWCPPYNLP WRKSAGEVLM TISRHGLSVN
260 270 280 290 300
VVKYIHEKEC LSTCVQNMQQ SDDLSPLEIV EMFAGLSCFL KDSSDVSQTL
310 320 330 340 350
LDDFRIWQGY NFLCDLLLRL EQAKEAESKD ALKDLVNLIT SLTTYGVSEL
360 370 380 390 400
KPAGITTGAP FLLPGFAVPQ PAGKGHSVRN VQAFAVLQNA FLKAKTSFLA
410 420 430 440 450
QIILDAITNI YMADNANYFI LESQHTLSQF AEKISKLPEV QNKYFEMLEF
460 470 480 490 500
VVFSLNYIPC KELISVSILL KSSSSYHCSI IAMKTLLKFT RHDYIFKDVF
510 520 530 540 550
REVGLLEVMV NLLHKYAALL KDPTQALNEQ GDSRNNSSVE DQKHLALLVM
560 570 580 590 600
ETLTVLLQGS NTNAGIFREF GGARCAHNIV KYPQCRQHAL MTIQQLVLSP
610 620 630 640 650
NGDDDMGTLL GLMHSAPPTE LQLKTDILRA LLSVLRESHR SRTVFRKVGG
660 670 680 690 700
FVYITSLLVA MERSLSCPPK NGWEKVNQNQ VFELLHTVFC TLTAAMRYEP
710 720 730 740 750
ANSHFFKTEI QYEKLADAVR FLGCFSDLRK ISAMNVFPSN TQPFQRLLEE
760 770 780 790 800
DVISIESVSP TLRHCSKLFI YLYKVATDSF DSRAEQIPPC LTSESSLPSP
810 820 830 840 850
WGTPALSRKR HAYHSVSTPP VYPPKNVADL KLHVTTSSLQ SSDAVIIHPG
860 870 880 890 900
AMLAMLDLLA SVGSVTQPEH ALDLQLAVAN ILQSLVHTER NQQVMCEAGL
910 920 930 940 950
HARLLQRCSA ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLASPL
960 970 980 990 1000
NCGAWDKKLL KQYRVHKPSS LSYEPEMRSS MITSLEGLGT DNVFSLHEDN
1010 1020 1030 1040 1050
HYRISKSLVK SAEGSTVPLT RVKCLVSMTT PHDIRLHGSS VTPAFVEFDT
1060 1070 1080 1090 1100
SLEGFGCLFL PSLAPHNAPT NNTVTTGLID GAVVSGIGSG ERFFPPPSGL
1110 1120 1130 1140 1150
SYSSWFCIEH FSSPPNNHPV RLLTVVRRAN SSEQHYVCLA IVLSAKDRSL
1160 1170 1180 1190 1200
IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGELIIE GQWHHLVLVM
1210 1220 1230 1240 1250
SKGMLKNSTA ALYIDGQLVN TVKLHYVHST PGGSGSANPP VVSTVYAYIG
1260 1270 1280 1290 1300
TPPAQRQIAS LVWRLGPTHF LEEVLPSSNV TTIYELGPNY VGSFQAVCMP
1310 1320 1330 1340 1350
CKDAKSEGVV PSPVSLVPEE KVSFGLYALS VSSLTVARIR KVYNKLDSKA
1360 1370 1380 1390 1400
IAKQLGISSH ENATPVKLIH NSAGHLNGSA RTIGAALIGY LGVRTFVPKP
1410 1420 1430 1440 1450
VATTLQYVGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS NPLASKEMER
1460 1470 1480 1490 1500
IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD
1510 1520 1530 1540 1550
LLCDFEVWLH APYELHLSLF EHFIELLTES SEASKNAKLM REFQLIPKLL
1560 1570 1580 1590 1600
LTLRDMSLSQ PTIAAISNVL SFLLQGFPSS NDLLRFGQFI SSTLPTFAVC
1610 1620 1630 1640 1650
EKFVVMEINN EEKLDTGTEE EFGGLVSANL ILLRNRLLDI LLKLIYTSKE
1660 1670 1680 1690 1700
KTSINLQACE ELVKTLGFDW IMMFMEEHLH STTVTAAMRI LVVLLSNQSI
1710 1720 1730 1740 1750
LIKFKEGLSG GGWLEQTDSV LTNKIGTVLG FNVGRSAGGR STVREINRDA
1760 1770 1780 1790 1800
CHFPGFPVLQ SFLPKHTNVP ALYFLLMALF LQQPVSELPE NLQVSVPVIS
1810 1820 1830 1840 1850
CRSKQGCQFD LDSIWTFIFG VPASSGTVVS SIHNVCTEAV FLLLGMLRSM
1860 1870 1880 1890 1900
LTSPWQSEEE GSWLREYPVT LMQFFRYLYH NVPDLASMWM SPDFLCALAA
1910 1920 1930 1940 1950
TVFPFNIRPY SEMVTDLDDE VGSPAEEFKA FAADTGMNRS QSEYCNVGTK
1960 1970 1980 1990 2000
TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS KQTPLIDLLL EASPERSTRT
2010 2020 2030 2040 2050
QQKEFQTYIL DSVMDHLLAA DVLLGEDASL PITSGGSYQV LVNNVFYFTQ
2060 2070 2080 2090 2100
RVVDKLWQGM FNKESKLLID FIIQLIAQSK RRSQGLSLDA VYHCLNRTIL
2110 2120 2130 2140 2150
YQFSRAHKTV PQQVALLDSL RVLTVNRNLI LGPGNHDQEF ISCLAHCLIN
2160 2170 2180 2190 2200
LHVGSNVDGF GLEAEARMTT WHIMIPSDIE PDGSYSQDIS EGRQLLIKAV
2210 2220 2230 2240 2250
NRVWTELIHS KKQVLEELFK VTLPVNERGH VDIATARPLI EEAALKCWQN
2260 2270 2280 2290 2300
HLAHEKKCIS RGEALAPTTQ SKLSRVSSGF GLSKLTGSRR NRKESGLNKH
2310 2320 2330 2340 2350
SLSTQEISQW MFTHIAVVRD LVDTQYKEYQ ERQQNALKYV TEEWCQIECE
2360 2370 2380 2390 2400
LLRERGLWGP PIGSHLDKWM LEMTEGPCRM RKKMVRNDMF YNHYPYVPET
2410 2420 2430 2440 2450
EQETNVASEI PSKQPETPDD IPQKKPARYR RAVSYDSKEY YMRLASGNPA
2460 2470 2480 2490 2500
IVQDAIVESS EGEAAQQEPE HGEDTIAKVK GLVKPPLKRS RSAPDGGDEE
2510 2520 2530 2540 2550
NQEQLQDQIA EGSSIEEEEK TDNATLLRLL EEGEKIQHMY RCARVQGLDT
2560 2570 2580 2590 2600
SEGLLLFGKE HFYVIDGFTM TATREIRDIE TLPPNMHEPI IPRGARQGPS
2610 2620 2630 2640 2650
QLKRTCSIFA YEDIKEVHKR RYLLQPIAVE VFSGDGRNYL LAFQKGIRNK
2660 2670 2680 2690 2700
VYQRFLAVVP SLTDSSESVS GQRPNTSVEQ GSGLLSTLVG EKSVTQRWER
2710 2720 2730 2740 2750
GEISNFQYLM HLNTLAGRSY NDLMQYPVFP WILADYDSEE VDLTNPKTFR
2760 2770 2780 2790 2800
NLAKPMGAQT DERLAQYKKR YKDWEDPNGE TPAYHYGTHY SSAMIVASYL
2810 2820 2830 2840 2850
VRMEPFTQIF LRLQGGHFDL ADRMFHSVRE AWYSASKHNM ADVKELIPEF
2860 2870 2880 2890 2900
FYLPEFLFNS NNFDLGCKQN GTKLGDVILP PWAKGDPREF IRVHREALEC
2910 2920 2930 2940 2950
DYVSAHLHEW IDLIFGYKQQ GPAAVEAVNV FHHLFYEGQV DIYNINDPLK
2960 2970 2980 2990 3000
ETATIGFINN FGQIPKQLFK KPHPPKRVRS RLNGDNAGIS VLPGSTSDKI
3010 3020 3030 3040 3050
FFHHLDNLRP SLTPVKELKE PVGQIVCTDK GILAVEQNKV LIPPTWNKTF
3060 3070 3080 3090 3100
AWGYADLSCR LGTYESDKAM TVYECLSEWG QILCAICPNP KLVITGGTST
3110 3120 3130 3140 3150
VVCVWEMGTS KEKAKTVTLK QALLGHTDTV TCATASLAYH IIVSGSRDRT
3160 3170 3180 3190 3200
CIIWDLNKLS FLTQLRGHRA PVSALCINEL TGDIVSCAGT YIHVWSINGN
3210 3220 3230 3240 3250
PIVSVNTFTG RSQQIICCCM SEMNEWDTQN VIVTGHSDGV VRFWRMEFLQ
3260 3270 3280 3290 3300
VPETPAPEPA EVLEMQEDCP EAQIGQEAQD EDSSDSEADE QSISQDPKDT
3310 3320 3330 3340 3350
PSQPSSTSHR PRAASCRATA AWCTDSGSDD SRRWSDQLSL DEKDGFIFVN
3360 3370 3380 3390 3400
YSEGQTRAHL QGPLSHPHPN PIEVRNYSRL KPGYRWERQL VFRSKLTMHT
3410 3420 3430 3440 3450
AFDRKDNAHP AEVTALGISK DHSRILVGDS RGRVFSWSVS DQPGRSAADH
3460 3470 3480 3490 3500
WVKDEGGDSC SGCSVRFSLT ERRHHCRNCG QLFCQKCSRF QSEIKRLKIS
3510 3520
SPVRVCQNCY YNLQHERGSE DGPRNC
Length:3,526
Mass (Da):395,258
Last modified:June 27, 2006 - v2
Checksum:iF4D518E8C9C12E23
GO
Isoform 2 (identifier: Q8IZQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2408-2424: Missing.

Show »
Length:3,509
Mass (Da):393,367
Checksum:i5DF8D0918CD685F6
GO

Sequence cautioni

The sequence AAH13377 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH15214 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71020 differs from that shown. Aberrant splicing.Curated
The sequence BAC04455 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2944N → T in AAN15137 (PubMed:15292400).Curated1
Sequence conflicti3396L → P in BAB71020 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0268643032I → V.Corresponds to variant rs17368018dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194752408 – 2424Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF538685 mRNA. Translation: AAN15137.1.
AC095046 Genomic DNA. Translation: AAY40903.1.
AC104082 Genomic DNA. No translation available.
AB023210 mRNA. Translation: BAA76837.2.
AK055806 mRNA. Translation: BAB71020.1. Sequence problems.
AK094910 mRNA. Translation: BAC04455.1. Different initiation.
BC013377 mRNA. Translation: AAH13377.1. Different initiation.
BC015214 mRNA. Translation: AAH15214.2. Different initiation.
BC065502 mRNA. Translation: AAH65502.1.
BC119633 mRNA. Translation: AAI19634.1.
CCDSiCCDS3609.1. [Q8IZQ1-1]
RefSeqiNP_055806.2. NM_014991.4. [Q8IZQ1-1]
XP_011530065.1. XM_011531763.2. [Q8IZQ1-1]
XP_011530067.1. XM_011531765.2. [Q8IZQ1-2]
UniGeneiHs.480116.
Hs.726339.

Genome annotation databases

EnsembliENST00000295888; ENSP00000295888; ENSG00000163625. [Q8IZQ1-1]
GeneIDi23001.
KEGGihsa:23001.
UCSCiuc003hpd.4. human. [Q8IZQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF538685 mRNA. Translation: AAN15137.1.
AC095046 Genomic DNA. Translation: AAY40903.1.
AC104082 Genomic DNA. No translation available.
AB023210 mRNA. Translation: BAA76837.2.
AK055806 mRNA. Translation: BAB71020.1. Sequence problems.
AK094910 mRNA. Translation: BAC04455.1. Different initiation.
BC013377 mRNA. Translation: AAH13377.1. Different initiation.
BC015214 mRNA. Translation: AAH15214.2. Different initiation.
BC065502 mRNA. Translation: AAH65502.1.
BC119633 mRNA. Translation: AAI19634.1.
CCDSiCCDS3609.1. [Q8IZQ1-1]
RefSeqiNP_055806.2. NM_014991.4. [Q8IZQ1-1]
XP_011530065.1. XM_011531763.2. [Q8IZQ1-1]
XP_011530067.1. XM_011531765.2. [Q8IZQ1-2]
UniGeneiHs.480116.
Hs.726339.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WIMX-ray2.60B3341-3354[»]
ProteinModelPortaliQ8IZQ1.
SMRiQ8IZQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116647. 62 interactors.
IntActiQ8IZQ1. 43 interactors.
MINTiMINT-4829131.
STRINGi9606.ENSP00000295888.

PTM databases

iPTMnetiQ8IZQ1.
PhosphoSitePlusiQ8IZQ1.

Polymorphism and mutation databases

BioMutaiWDFY3.
DMDMi109896161.

Proteomic databases

EPDiQ8IZQ1.
MaxQBiQ8IZQ1.
PaxDbiQ8IZQ1.
PeptideAtlasiQ8IZQ1.
PRIDEiQ8IZQ1.

Protocols and materials databases

DNASUi23001.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295888; ENSP00000295888; ENSG00000163625. [Q8IZQ1-1]
GeneIDi23001.
KEGGihsa:23001.
UCSCiuc003hpd.4. human. [Q8IZQ1-1]

Organism-specific databases

CTDi23001.
DisGeNETi23001.
GeneCardsiWDFY3.
H-InvDBHIX0004348.
HGNCiHGNC:20751. WDFY3.
HPAiHPA042734.
HPA048572.
neXtProtiNX_Q8IZQ1.
OpenTargetsiENSG00000163625.
PharmGKBiPA134903706.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1786. Eukaryota.
KOG1788. Eukaryota.
ENOG410XNQC. LUCA.
GeneTreeiENSGT00760000119083.
HOVERGENiHBG094156.
InParanoidiQ8IZQ1.
OMAiGPTHFLE.
OrthoDBiEOG091G002Q.
PhylomeDBiQ8IZQ1.
TreeFamiTF313658.

Enzyme and pathway databases

SignaLinkiQ8IZQ1.

Miscellaneous databases

ChiTaRSiWDFY3. human.
GeneWikiiWDFY3.
GenomeRNAii23001.
PROiQ8IZQ1.

Gene expression databases

BgeeiENSG00000163625.
CleanExiHS_WDFY3.
ExpressionAtlasiQ8IZQ1. baseline and differential.
GenevisibleiQ8IZQ1. HS.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
1.25.10.10. 2 hits.
2.130.10.10. 2 hits.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF15787. DUF4704. 1 hit.
PF01363. FYVE. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00064. FYVE. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF57903. SSF57903. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDFY3_HUMAN
AccessioniPrimary (citable) accession number: Q8IZQ1
Secondary accession number(s): Q4W5K5
, Q6P0Q5, Q8N1T2, Q8NAV6, Q96BS7, Q96D33, Q96N85, Q9Y2J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.