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Q8IZP9

- GPR64_HUMAN

UniProt

Q8IZP9 - GPR64_HUMAN

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Protein

G-protein coupled receptor 64

Gene

GPR64

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Could be involved in a signal transduction pathway controlling epididymal function and male fertility.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. neuropeptide signaling pathway Source: InterPro
  3. spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.010.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 64
Alternative name(s):
Human epididymis-specific protein 6
Short name:
He6
Gene namesi
Name:GPR64
Synonyms:HE6, TM7LN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:4516. GPR64.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cell surface Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of membrane Source: GDB
  5. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 1017980G-protein coupled receptor 64PRO_0000012886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi551 – 5511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi597 – 5971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis
Modified residuei1010 – 10101Phosphoserine1 Publication

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.Curated

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8IZP9.
PaxDbiQ8IZP9.
PRIDEiQ8IZP9.

PTM databases

PhosphoSiteiQ8IZP9.

Expressioni

Tissue specificityi

Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia.

Gene expression databases

BgeeiQ8IZP9.
ExpressionAtlasiQ8IZP9. baseline and differential.
GenevestigatoriQ8IZP9.

Organism-specific databases

HPAiHPA001478.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety.Curated

Protein-protein interaction databases

BioGridi115451. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8IZP9.
SMRiQ8IZP9. Positions 631-880.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 627590ExtracellularSequence AnalysisAdd
BLAST
Topological domaini649 – 66719CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini689 – 6935ExtracellularSequence Analysis
Topological domaini715 – 73723CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini759 – 78931ExtracellularSequence AnalysisAdd
BLAST
Topological domaini811 – 83424CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini856 – 8572ExtracellularSequence Analysis
Topological domaini879 – 1017139CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei628 – 64821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei668 – 68821Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei694 – 71421Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei738 – 75821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei790 – 81021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei835 – 85521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei858 – 87821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini567 – 61852GPSPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi672 – 6776Poly-Leu
Compositional biasi816 – 8194Poly-Lys
Compositional biasi925 – 9306Poly-Ser

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118787.
HOVERGENiHBG051817.
InParanoidiQ8IZP9.
KOiK08451.
OMAiFIFYCVA.
OrthoDBiEOG7ZGX28.
PhylomeDBiQ8IZP9.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 10 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZP9-1) [UniParc]FASTAAdd to Basket

Also known as: Long splice variant

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP
60 70 80 90 100
PAKLSVVSFA PSSNGTPEVE TTSLNDVTLS LLPSNETEKT KITIVKTFNA
110 120 130 140 150
SGVKPQRNIC NLSSICNDSA FFRGEIMFQY DKESTVPQNQ HITNGTLTGV
160 170 180 190 200
LSLSELKRSE LNKTLQTLSE TYFIMCATAE AQSTLNCTFT IKLNNTMNAC
210 220 230 240 250
AVIAALERVK IRPMEHCCCS VRIPCPSSPE ELEKLQCDLQ DPIVCLADHP
260 270 280 290 300
RGPPFSSSQS IPVVPRATVL SQVPKATSFA EPPDYSPVTH NVPSPIGEIQ
310 320 330 340 350
PLSPQPSAPI ASSPAIDMPP QSETISSPMP QTHVSGTPPP VKASFSSPTV
360 370 380 390 400
SAPANVNTTS APPVQTDIVN TSSISDLENQ VLQMEKALSL GSLEPNLAGE
410 420 430 440 450
MINQVSRLLH SPPDMLAPLA QRLLKVVDDI GLQLNFSNTT ISLTSPSLAL
460 470 480 490 500
AVIRVNASSF NTTTFVAQDP ANLQVSLETQ APENSIGTIT LPSSLMNNLP
510 520 530 540 550
AHDMELASRV QFNFFETPAL FQDPSLENLS LISYVISSSV ANLTVRNLTR
560 570 580 590 600
NVTVTLKHIN PSQDELTVRC VFWDLGRNGG RGGWSDNGCS VKDRRLNETI
610 620 630 640 650
CTCSHLTSFG VLLDLSRTSV LPAQMMALTF ITYIGCGLSS IFLSVTLVTY
660 670 680 690 700
IAFEKIRRDY PSKILIQLCA ALLLLNLVFL LDSWIALYKM QGLCISVAVF
710 720 730 740 750
LHYFLLVSFT WMGLEAFHMY LALVKVFNTY IRKYILKFCI VGWGVPAVVV
760 770 780 790 800
TIILTISPDN YGLGSYGKFP NGSPDDFCWI NNNAVFYITV VGYFCVIFLL
810 820 830 840 850
NVSMFIVVLV QLCRIKKKKQ LGAQRKTSIQ DLRSIAGLTF LLGITWGFAF
860 870 880 890 900
FAWGPVNVTF MYLFAIFNTL QGFFIFIFYC VAKENVRKQW RRYLCCGKLR
910 920 930 940 950
LAENSDWSKT ATNGLKKQTV NQGVSSSSNS LQSSSNSTNS TTLLVNNDCS
960 970 980 990 1000
VHASGNGNAS TERNGVSFSV QNGDVCLHDF TGKQHMFNEK EDSCNGKGRM
1010
ALRRTSKRGS LHFIEQM
Length:1,017
Mass (Da):111,593
Last modified:May 5, 2009 - v2
Checksum:i2E0839DB45B6C553
GO
Isoform 2 (identifier: Q8IZP9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-67: Missing.

Show »
Length:1,014
Mass (Da):111,337
Checksum:i2EFFA8C485F8AB9A
GO
Isoform 3 (identifier: Q8IZP9-3) [UniParc]FASTAAdd to Basket

Also known as: d1

The sequence of this isoform differs from the canonical sequence as follows:
     51-66: Missing.

Show »
Length:1,001
Mass (Da):110,049
Checksum:i2FC89014C20F574B
GO
Isoform 4 (identifier: Q8IZP9-4) [UniParc]FASTAAdd to Basket

Also known as: 24

The sequence of this isoform differs from the canonical sequence as follows:
     88-101: Missing.

Show »
Length:1,003
Mass (Da):110,031
Checksum:i71EF3C56C15E3FDE
GO
Isoform 5 (identifier: Q8IZP9-5) [UniParc]FASTAAdd to Basket

Also known as: 23

The sequence of this isoform differs from the canonical sequence as follows:
     52-75: Missing.

Show »
Length:993
Mass (Da):109,175
Checksum:i6C0F14BEEB6BB6AD
GO
Isoform 6 (identifier: Q8IZP9-6) [UniParc]FASTAAdd to Basket

Also known as: d3

The sequence of this isoform differs from the canonical sequence as follows:
     68-101: EVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

Show »
Length:995
Mass (Da):109,157
Checksum:iC351BA0D891CA0D3
GO
Isoform 7 (identifier: Q8IZP9-7) [UniParc]FASTAAdd to Basket

Also known as: d2

The sequence of this isoform differs from the canonical sequence as follows:
     52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → EVETTSLNDVTLSLLPSNET

Show »
Length:987
Mass (Da):108,487
Checksum:iFD8CB3C2B139A78B
GO
Isoform 8 (identifier: Q8IZP9-8) [UniParc]FASTAAdd to Basket

Also known as: 21

The sequence of this isoform differs from the canonical sequence as follows:
     52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

Show »
Length:979
Mass (Da):107,613
Checksum:i49B0950AC074B2F1
GO
Isoform 9 (identifier: Q8IZP9-9) [UniParc]FASTAAdd to Basket

Also known as: Delta exon 28

The sequence of this isoform differs from the canonical sequence as follows:
     906-956: Missing.

Show »
Length:966
Mass (Da):106,353
Checksum:i042D243C632F9B35
GO
Isoform 10 (identifier: Q8IZP9-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-66: Missing.
     88-101: Missing.
     474-562: Missing.

Note: No experimental confirmation available.

Show »
Length:898
Mass (Da):98,720
Checksum:iE4820F94AD64A73B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021V → A in CAA57479. (PubMed:9150425)Curated
Sequence conflicti202 – 2021V → A in AAN33056. (PubMed:12420295)Curated
Sequence conflicti202 – 2021V → A in AAN33064. (PubMed:12420295)Curated
Sequence conflicti202 – 2021V → A in AAN33065. (PubMed:12420295)Curated
Sequence conflicti202 – 2021V → A in AAN38971. (PubMed:12420295)Curated
Sequence conflicti202 – 2021V → A in AAN38972. (PubMed:12420295)Curated
Sequence conflicti202 – 2021V → A in AAN38973. (PubMed:12420295)Curated
Sequence conflicti202 – 2021V → A in AAN38974. (PubMed:12420295)Curated
Sequence conflicti202 – 2021V → A in AAN75702. (PubMed:12420295)Curated
Sequence conflicti233 – 2331E → G in CAA57479. (PubMed:9150425)Curated
Sequence conflicti233 – 2331E → G in AAN33056. (PubMed:12420295)Curated
Sequence conflicti233 – 2331E → G in AAN33064. (PubMed:12420295)Curated
Sequence conflicti233 – 2331E → G in AAN33065. (PubMed:12420295)Curated
Sequence conflicti233 – 2331E → G in AAN38971. (PubMed:12420295)Curated
Sequence conflicti233 – 2331E → G in AAN38972. (PubMed:12420295)Curated
Sequence conflicti233 – 2331E → G in AAN38973. (PubMed:12420295)Curated
Sequence conflicti233 – 2331E → G in AAN38974. (PubMed:12420295)Curated
Sequence conflicti233 – 2331E → G in AAN75702. (PubMed:12420295)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti290 – 2901H → Q.
Corresponds to variant rs35974297 [ dbSNP | Ensembl ].
VAR_055289
Natural varianti771 – 7711N → S.
Corresponds to variant rs3924227 [ dbSNP | Ensembl ].
VAR_055290

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei51 – 6616Missing in isoform 3 and isoform 10. 2 PublicationsVSP_009792Add
BLAST
Alternative sequencei52 – 10150AKLSV…TFNAS → EVETTSLNDVTLSLLPSNET in isoform 7. 1 PublicationVSP_009796Add
BLAST
Alternative sequencei52 – 10150AKLSV…TFNAS → DVTLSLLPSNET in isoform 8. 1 PublicationVSP_009797Add
BLAST
Alternative sequencei52 – 7524Missing in isoform 5. 1 PublicationVSP_009794Add
BLAST
Alternative sequencei65 – 673Missing in isoform 2. 1 PublicationVSP_009791
Alternative sequencei68 – 10134EVETT…TFNAS → DVTLSLLPSNET in isoform 6. 1 PublicationVSP_009795Add
BLAST
Alternative sequencei88 – 10114Missing in isoform 4 and isoform 10. 2 PublicationsVSP_009793Add
BLAST
Alternative sequencei474 – 56289Missing in isoform 10. 1 PublicationVSP_054522Add
BLAST
Alternative sequencei906 – 95651Missing in isoform 9. 1 PublicationVSP_009798Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81892 mRNA. Translation: CAA57479.1.
AF538954 mRNA. Translation: AAN33056.1.
AF539455 mRNA. Translation: AAN33064.1.
AF539456 mRNA. Translation: AAN33065.1.
AY143364 mRNA. Translation: AAN38971.1.
AY143365 mRNA. Translation: AAN38972.1.
AY143366 mRNA. Translation: AAN38973.1.
AY143367 mRNA. Translation: AAN38974.1.
AY148343 mRNA. Translation: AAN75702.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40668.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40669.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40670.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40671.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41675.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41676.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41677.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41678.1.
BC113979 mRNA. Translation: AAI13980.1.
CCDSiCCDS14191.1. [Q8IZP9-2]
CCDS43921.1. [Q8IZP9-6]
CCDS43922.1. [Q8IZP9-4]
CCDS43923.1. [Q8IZP9-1]
CCDS55376.1. [Q8IZP9-5]
CCDS55377.1. [Q8IZP9-7]
CCDS55378.1. [Q8IZP9-3]
CCDS55379.1. [Q8IZP9-9]
RefSeqiNP_001073327.1. NM_001079858.2. [Q8IZP9-1]
NP_001073328.1. NM_001079859.2. [Q8IZP9-4]
NP_001073329.1. NM_001079860.2. [Q8IZP9-6]
NP_001171762.1. NM_001184833.1. [Q8IZP9-3]
NP_001171763.1. NM_001184834.1. [Q8IZP9-9]
NP_001171764.1. NM_001184835.1. [Q8IZP9-8]
NP_001171765.1. NM_001184836.1. [Q8IZP9-5]
NP_001171766.1. NM_001184837.1. [Q8IZP9-7]
NP_005747.2. NM_005756.3. [Q8IZP9-2]
XP_006724518.1. XM_006724455.1. [Q8IZP9-1]
UniGeneiHs.146978.

Genome annotation databases

EnsembliENST00000340581; ENSP00000344972; ENSG00000173698. [Q8IZP9-10]
ENST00000354791; ENSP00000346845; ENSG00000173698. [Q8IZP9-10]
ENST00000356606; ENSP00000349015; ENSG00000173698. [Q8IZP9-4]
ENST00000357544; ENSP00000350152; ENSG00000173698. [Q8IZP9-7]
ENST00000357991; ENSP00000350680; ENSG00000173698. [Q8IZP9-2]
ENST00000360279; ENSP00000353421; ENSG00000173698. [Q8IZP9-6]
ENST00000379869; ENSP00000369198; ENSG00000173698. [Q8IZP9-1]
ENST00000379873; ENSP00000369202; ENSG00000173698. [Q8IZP9-9]
ENST00000379876; ENSP00000369205; ENSG00000173698. [Q8IZP9-5]
ENST00000379878; ENSP00000369207; ENSG00000173698. [Q8IZP9-3]
GeneIDi10149.
KEGGihsa:10149.
UCSCiuc004cyx.3. human. [Q8IZP9-1]
uc004cyy.3. human. [Q8IZP9-2]
uc004cyz.3. human. [Q8IZP9-4]
uc004cza.3. human. [Q8IZP9-6]
uc004czb.3. human. [Q8IZP9-9]
uc004czc.3. human. [Q8IZP9-3]
uc004czd.3. human. [Q8IZP9-5]
uc004cze.3. human. [Q8IZP9-7]
uc004czf.3. human. [Q8IZP9-8]
uc010nfj.3. human.

Polymorphism databases

DMDMi229462874.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81892 mRNA. Translation: CAA57479.1 .
AF538954 mRNA. Translation: AAN33056.1 .
AF539455 mRNA. Translation: AAN33064.1 .
AF539456 mRNA. Translation: AAN33065.1 .
AY143364 mRNA. Translation: AAN38971.1 .
AY143365 mRNA. Translation: AAN38972.1 .
AY143366 mRNA. Translation: AAN38973.1 .
AY143367 mRNA. Translation: AAN38974.1 .
AY148343 mRNA. Translation: AAN75702.1 .
AL732578 , AL732509 Genomic DNA. Translation: CAI40668.1 .
AL732578 , AL732509 Genomic DNA. Translation: CAI40669.1 .
AL732578 , AL732509 Genomic DNA. Translation: CAI40670.1 .
AL732578 , AL732509 Genomic DNA. Translation: CAI40671.1 .
AL732509 , AL732578 Genomic DNA. Translation: CAI41675.1 .
AL732509 , AL732578 Genomic DNA. Translation: CAI41676.1 .
AL732509 , AL732578 Genomic DNA. Translation: CAI41677.1 .
AL732509 , AL732578 Genomic DNA. Translation: CAI41678.1 .
BC113979 mRNA. Translation: AAI13980.1 .
CCDSi CCDS14191.1. [Q8IZP9-2 ]
CCDS43921.1. [Q8IZP9-6 ]
CCDS43922.1. [Q8IZP9-4 ]
CCDS43923.1. [Q8IZP9-1 ]
CCDS55376.1. [Q8IZP9-5 ]
CCDS55377.1. [Q8IZP9-7 ]
CCDS55378.1. [Q8IZP9-3 ]
CCDS55379.1. [Q8IZP9-9 ]
RefSeqi NP_001073327.1. NM_001079858.2. [Q8IZP9-1 ]
NP_001073328.1. NM_001079859.2. [Q8IZP9-4 ]
NP_001073329.1. NM_001079860.2. [Q8IZP9-6 ]
NP_001171762.1. NM_001184833.1. [Q8IZP9-3 ]
NP_001171763.1. NM_001184834.1. [Q8IZP9-9 ]
NP_001171764.1. NM_001184835.1. [Q8IZP9-8 ]
NP_001171765.1. NM_001184836.1. [Q8IZP9-5 ]
NP_001171766.1. NM_001184837.1. [Q8IZP9-7 ]
NP_005747.2. NM_005756.3. [Q8IZP9-2 ]
XP_006724518.1. XM_006724455.1. [Q8IZP9-1 ]
UniGenei Hs.146978.

3D structure databases

ProteinModelPortali Q8IZP9.
SMRi Q8IZP9. Positions 631-880.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115451. 1 interaction.

Protein family/group databases

MEROPSi S63.010.
GPCRDBi Search...

PTM databases

PhosphoSitei Q8IZP9.

Polymorphism databases

DMDMi 229462874.

Proteomic databases

MaxQBi Q8IZP9.
PaxDbi Q8IZP9.
PRIDEi Q8IZP9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340581 ; ENSP00000344972 ; ENSG00000173698 . [Q8IZP9-10 ]
ENST00000354791 ; ENSP00000346845 ; ENSG00000173698 . [Q8IZP9-10 ]
ENST00000356606 ; ENSP00000349015 ; ENSG00000173698 . [Q8IZP9-4 ]
ENST00000357544 ; ENSP00000350152 ; ENSG00000173698 . [Q8IZP9-7 ]
ENST00000357991 ; ENSP00000350680 ; ENSG00000173698 . [Q8IZP9-2 ]
ENST00000360279 ; ENSP00000353421 ; ENSG00000173698 . [Q8IZP9-6 ]
ENST00000379869 ; ENSP00000369198 ; ENSG00000173698 . [Q8IZP9-1 ]
ENST00000379873 ; ENSP00000369202 ; ENSG00000173698 . [Q8IZP9-9 ]
ENST00000379876 ; ENSP00000369205 ; ENSG00000173698 . [Q8IZP9-5 ]
ENST00000379878 ; ENSP00000369207 ; ENSG00000173698 . [Q8IZP9-3 ]
GeneIDi 10149.
KEGGi hsa:10149.
UCSCi uc004cyx.3. human. [Q8IZP9-1 ]
uc004cyy.3. human. [Q8IZP9-2 ]
uc004cyz.3. human. [Q8IZP9-4 ]
uc004cza.3. human. [Q8IZP9-6 ]
uc004czb.3. human. [Q8IZP9-9 ]
uc004czc.3. human. [Q8IZP9-3 ]
uc004czd.3. human. [Q8IZP9-5 ]
uc004cze.3. human. [Q8IZP9-7 ]
uc004czf.3. human. [Q8IZP9-8 ]
uc010nfj.3. human.

Organism-specific databases

CTDi 10149.
GeneCardsi GC0XM019007.
H-InvDB HIX0016685.
HGNCi HGNC:4516. GPR64.
HPAi HPA001478.
MIMi 300572. gene.
neXtProti NX_Q8IZP9.
PharmGKBi PA28908.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118787.
HOVERGENi HBG051817.
InParanoidi Q8IZP9.
KOi K08451.
OMAi FIFYCVA.
OrthoDBi EOG7ZGX28.
PhylomeDBi Q8IZP9.
TreeFami TF321769.

Miscellaneous databases

GeneWikii GPR64.
GenomeRNAii 10149.
NextBioi 38407.
PROi Q8IZP9.
SOURCEi Search...

Gene expression databases

Bgeei Q8IZP9.
ExpressionAtlasi Q8IZP9. baseline and differential.
Genevestigatori Q8IZP9.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00303. GPS. 1 hit.
[Graphical view ]
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily."
    Osterhoff C., Ivell R., Kirchhoff C.
    DNA Cell Biol. 16:379-389(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Epididymis.
  2. "HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia."
    Obermann H., Samalecos A., Osterhoff C., Schroeder B., Heller R., Kirchhoff C.
    Mol. Reprod. Dev. 64:13-26(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6; 7; 8 AND 9).
    Tissue: Epididymis.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10).
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiGPR64_HUMAN
AccessioniPrimary (citable) accession number: Q8IZP9
Secondary accession number(s): B1AWB3
, B1AWB4, B1AWB6, B1AWB7, O00406, Q14CE0, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3