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Protein

Adhesion G-protein coupled receptor G2

Gene

ADGRG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G21 Publication
Alternative name(s):
G-protein coupled receptor 64
Human epididymis-specific protein 6
Short name:
He6
Gene namesi
Name:ADGRG2Imported
Synonyms:GPR64, HE6, TM7LN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4516. ADGRG2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini38 – 627ExtracellularCuratedAdd BLAST590
Transmembranei628 – 648Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini649 – 667CytoplasmicCuratedAdd BLAST19
Transmembranei668 – 688Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini689 – 693ExtracellularCurated5
Transmembranei694 – 714Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini715 – 737CytoplasmicCuratedAdd BLAST23
Transmembranei738 – 758Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini759 – 789ExtracellularCuratedAdd BLAST31
Transmembranei790 – 810Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini811 – 834CytoplasmicCuratedAdd BLAST24
Transmembranei835 – 855Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini856 – 857ExtracellularCurated2
Transmembranei858 – 878Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini879 – 1017CytoplasmicCuratedAdd BLAST139

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: GDB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10149.
OpenTargetsiENSG00000173698.
PharmGKBiPA28908.

Polymorphism and mutation databases

BioMutaiGPR64.
DMDMi229462874.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000001288638 – 1017Adhesion G-protein coupled receptor G2Add BLAST980

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Glycosylationi357N-linked (GlcNAc...)Sequence analysis1
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1
Glycosylationi435N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Glycosylationi461N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1
Glycosylationi542N-linked (GlcNAc...)Sequence analysis1
Glycosylationi547N-linked (GlcNAc...)Sequence analysis1
Glycosylationi551N-linked (GlcNAc...)Sequence analysis1
Glycosylationi597N-linked (GlcNAc...)Sequence analysis1
Glycosylationi857N-linked (GlcNAc...)Sequence analysis1
Modified residuei1010PhosphoserineCombined sources1

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.Curated
Highly glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8IZP9.
PaxDbiQ8IZP9.
PeptideAtlasiQ8IZP9.
PRIDEiQ8IZP9.

PTM databases

iPTMnetiQ8IZP9.
PhosphoSitePlusiQ8IZP9.

Expressioni

Tissue specificityi

Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung.4 Publications

Gene expression databases

BgeeiENSG00000173698.
GenevisibleiQ8IZP9. HS.

Organism-specific databases

HPAiHPA001478.

Interactioni

Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000369198.

Structurei

3D structure databases

ProteinModelPortaliQ8IZP9.
SMRiQ8IZP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini567 – 618GPSPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi672 – 677Poly-Leu6
Compositional biasi816 – 819Poly-Lys4
Compositional biasi925 – 930Poly-Ser6

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000231476.
HOVERGENiHBG051817.
InParanoidiQ8IZP9.
KOiK08451.
OMAiFIFYCVA.
OrthoDBiEOG091G00P5.
PhylomeDBiQ8IZP9.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZP9-1) [UniParc]FASTAAdd to basket
Also known as: Long splice variant

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP
60 70 80 90 100
PAKLSVVSFA PSSNGTPEVE TTSLNDVTLS LLPSNETEKT KITIVKTFNA
110 120 130 140 150
SGVKPQRNIC NLSSICNDSA FFRGEIMFQY DKESTVPQNQ HITNGTLTGV
160 170 180 190 200
LSLSELKRSE LNKTLQTLSE TYFIMCATAE AQSTLNCTFT IKLNNTMNAC
210 220 230 240 250
AVIAALERVK IRPMEHCCCS VRIPCPSSPE ELEKLQCDLQ DPIVCLADHP
260 270 280 290 300
RGPPFSSSQS IPVVPRATVL SQVPKATSFA EPPDYSPVTH NVPSPIGEIQ
310 320 330 340 350
PLSPQPSAPI ASSPAIDMPP QSETISSPMP QTHVSGTPPP VKASFSSPTV
360 370 380 390 400
SAPANVNTTS APPVQTDIVN TSSISDLENQ VLQMEKALSL GSLEPNLAGE
410 420 430 440 450
MINQVSRLLH SPPDMLAPLA QRLLKVVDDI GLQLNFSNTT ISLTSPSLAL
460 470 480 490 500
AVIRVNASSF NTTTFVAQDP ANLQVSLETQ APENSIGTIT LPSSLMNNLP
510 520 530 540 550
AHDMELASRV QFNFFETPAL FQDPSLENLS LISYVISSSV ANLTVRNLTR
560 570 580 590 600
NVTVTLKHIN PSQDELTVRC VFWDLGRNGG RGGWSDNGCS VKDRRLNETI
610 620 630 640 650
CTCSHLTSFG VLLDLSRTSV LPAQMMALTF ITYIGCGLSS IFLSVTLVTY
660 670 680 690 700
IAFEKIRRDY PSKILIQLCA ALLLLNLVFL LDSWIALYKM QGLCISVAVF
710 720 730 740 750
LHYFLLVSFT WMGLEAFHMY LALVKVFNTY IRKYILKFCI VGWGVPAVVV
760 770 780 790 800
TIILTISPDN YGLGSYGKFP NGSPDDFCWI NNNAVFYITV VGYFCVIFLL
810 820 830 840 850
NVSMFIVVLV QLCRIKKKKQ LGAQRKTSIQ DLRSIAGLTF LLGITWGFAF
860 870 880 890 900
FAWGPVNVTF MYLFAIFNTL QGFFIFIFYC VAKENVRKQW RRYLCCGKLR
910 920 930 940 950
LAENSDWSKT ATNGLKKQTV NQGVSSSSNS LQSSSNSTNS TTLLVNNDCS
960 970 980 990 1000
VHASGNGNAS TERNGVSFSV QNGDVCLHDF TGKQHMFNEK EDSCNGKGRM
1010
ALRRTSKRGS LHFIEQM
Length:1,017
Mass (Da):111,593
Last modified:May 5, 2009 - v2
Checksum:i2E0839DB45B6C553
GO
Isoform 2 (identifier: Q8IZP9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-67: Missing.

Show »
Length:1,014
Mass (Da):111,337
Checksum:i2EFFA8C485F8AB9A
GO
Isoform 3 (identifier: Q8IZP9-3) [UniParc]FASTAAdd to basket
Also known as: d1

The sequence of this isoform differs from the canonical sequence as follows:
     51-66: Missing.

Show »
Length:1,001
Mass (Da):110,049
Checksum:i2FC89014C20F574B
GO
Isoform 4 (identifier: Q8IZP9-4) [UniParc]FASTAAdd to basket
Also known as: 24

The sequence of this isoform differs from the canonical sequence as follows:
     88-101: Missing.

Show »
Length:1,003
Mass (Da):110,031
Checksum:i71EF3C56C15E3FDE
GO
Isoform 5 (identifier: Q8IZP9-5) [UniParc]FASTAAdd to basket
Also known as: 23

The sequence of this isoform differs from the canonical sequence as follows:
     52-75: Missing.

Show »
Length:993
Mass (Da):109,175
Checksum:i6C0F14BEEB6BB6AD
GO
Isoform 6 (identifier: Q8IZP9-6) [UniParc]FASTAAdd to basket
Also known as: d3

The sequence of this isoform differs from the canonical sequence as follows:
     68-101: EVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

Show »
Length:995
Mass (Da):109,157
Checksum:iC351BA0D891CA0D3
GO
Isoform 7 (identifier: Q8IZP9-7) [UniParc]FASTAAdd to basket
Also known as: d2

The sequence of this isoform differs from the canonical sequence as follows:
     52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → EVETTSLNDVTLSLLPSNET

Show »
Length:987
Mass (Da):108,487
Checksum:iFD8CB3C2B139A78B
GO
Isoform 8 (identifier: Q8IZP9-8) [UniParc]FASTAAdd to basket
Also known as: 21

The sequence of this isoform differs from the canonical sequence as follows:
     52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

Show »
Length:979
Mass (Da):107,613
Checksum:i49B0950AC074B2F1
GO
Isoform 9 (identifier: Q8IZP9-9) [UniParc]FASTAAdd to basket
Also known as: Delta exon 28

The sequence of this isoform differs from the canonical sequence as follows:
     906-956: Missing.

Show »
Length:966
Mass (Da):106,353
Checksum:i042D243C632F9B35
GO
Isoform 10 (identifier: Q8IZP9-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-66: Missing.
     88-101: Missing.
     474-562: Missing.

Note: No experimental confirmation available.
Show »
Length:898
Mass (Da):98,720
Checksum:iE4820F94AD64A73B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202V → A in CAA57479 (PubMed:9150425).Curated1
Sequence conflicti202V → A in AAN33056 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN33064 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN33065 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN38971 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN38972 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN38973 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN38974 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN75702 (PubMed:12420295).Curated1
Sequence conflicti233E → G in CAA57479 (PubMed:9150425).Curated1
Sequence conflicti233E → G in AAN33056 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN33064 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN33065 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN38971 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN38972 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN38973 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN38974 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN75702 (PubMed:12420295).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076259224P → S.1 PublicationCorresponds to variant rs140334931dbSNPEnsembl.1
Natural variantiVAR_055289290H → Q.Corresponds to variant rs35974297dbSNPEnsembl.1
Natural variantiVAR_055290771N → S.Corresponds to variant rs3924227dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00979251 – 66Missing in isoform 3 and isoform 10. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_00979652 – 101AKLSV…TFNAS → EVETTSLNDVTLSLLPSNET in isoform 7. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_00979752 – 101AKLSV…TFNAS → DVTLSLLPSNET in isoform 8. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_00979452 – 75Missing in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_00979165 – 67Missing in isoform 2. 1 Publication3
Alternative sequenceiVSP_00979568 – 101EVETT…TFNAS → DVTLSLLPSNET in isoform 6. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_00979388 – 101Missing in isoform 4 and isoform 10. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_054522474 – 562Missing in isoform 10. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_009798906 – 956Missing in isoform 9. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81892 mRNA. Translation: CAA57479.1.
AF538954 mRNA. Translation: AAN33056.1.
AF539455 mRNA. Translation: AAN33064.1.
AF539456 mRNA. Translation: AAN33065.1.
AY143364 mRNA. Translation: AAN38971.1.
AY143365 mRNA. Translation: AAN38972.1.
AY143366 mRNA. Translation: AAN38973.1.
AY143367 mRNA. Translation: AAN38974.1.
AY148343 mRNA. Translation: AAN75702.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40668.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40669.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40670.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40671.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41675.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41676.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41677.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41678.1.
BC113979 mRNA. Translation: AAI13980.1.
CCDSiCCDS14191.1. [Q8IZP9-2]
CCDS43921.1. [Q8IZP9-6]
CCDS43922.1. [Q8IZP9-4]
CCDS43923.1. [Q8IZP9-1]
CCDS55376.1. [Q8IZP9-5]
CCDS55377.1. [Q8IZP9-7]
CCDS55378.1. [Q8IZP9-3]
CCDS55379.1. [Q8IZP9-9]
RefSeqiNP_001073327.1. NM_001079858.2. [Q8IZP9-1]
NP_001073328.1. NM_001079859.2. [Q8IZP9-4]
NP_001073329.1. NM_001079860.2. [Q8IZP9-6]
NP_001171762.1. NM_001184833.1. [Q8IZP9-3]
NP_001171763.1. NM_001184834.1. [Q8IZP9-9]
NP_001171764.1. NM_001184835.1. [Q8IZP9-8]
NP_001171765.1. NM_001184836.1. [Q8IZP9-5]
NP_001171766.1. NM_001184837.1. [Q8IZP9-7]
NP_005747.2. NM_005756.3. [Q8IZP9-2]
XP_006724518.1. XM_006724455.3. [Q8IZP9-1]
XP_011543736.1. XM_011545434.1. [Q8IZP9-1]
XP_011543737.1. XM_011545435.2. [Q8IZP9-1]
UniGeneiHs.146978.

Genome annotation databases

EnsembliENST00000340581; ENSP00000344972; ENSG00000173698. [Q8IZP9-10]
ENST00000354791; ENSP00000346845; ENSG00000173698. [Q8IZP9-10]
ENST00000356606; ENSP00000349015; ENSG00000173698. [Q8IZP9-4]
ENST00000357544; ENSP00000350152; ENSG00000173698. [Q8IZP9-7]
ENST00000357991; ENSP00000350680; ENSG00000173698. [Q8IZP9-2]
ENST00000360279; ENSP00000353421; ENSG00000173698. [Q8IZP9-6]
ENST00000379869; ENSP00000369198; ENSG00000173698. [Q8IZP9-1]
ENST00000379873; ENSP00000369202; ENSG00000173698. [Q8IZP9-9]
ENST00000379876; ENSP00000369205; ENSG00000173698. [Q8IZP9-5]
ENST00000379878; ENSP00000369207; ENSG00000173698. [Q8IZP9-3]
GeneIDi10149.
KEGGihsa:10149.
UCSCiuc004cyx.4. human. [Q8IZP9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81892 mRNA. Translation: CAA57479.1.
AF538954 mRNA. Translation: AAN33056.1.
AF539455 mRNA. Translation: AAN33064.1.
AF539456 mRNA. Translation: AAN33065.1.
AY143364 mRNA. Translation: AAN38971.1.
AY143365 mRNA. Translation: AAN38972.1.
AY143366 mRNA. Translation: AAN38973.1.
AY143367 mRNA. Translation: AAN38974.1.
AY148343 mRNA. Translation: AAN75702.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40668.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40669.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40670.1.
AL732578, AL732509 Genomic DNA. Translation: CAI40671.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41675.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41676.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41677.1.
AL732509, AL732578 Genomic DNA. Translation: CAI41678.1.
BC113979 mRNA. Translation: AAI13980.1.
CCDSiCCDS14191.1. [Q8IZP9-2]
CCDS43921.1. [Q8IZP9-6]
CCDS43922.1. [Q8IZP9-4]
CCDS43923.1. [Q8IZP9-1]
CCDS55376.1. [Q8IZP9-5]
CCDS55377.1. [Q8IZP9-7]
CCDS55378.1. [Q8IZP9-3]
CCDS55379.1. [Q8IZP9-9]
RefSeqiNP_001073327.1. NM_001079858.2. [Q8IZP9-1]
NP_001073328.1. NM_001079859.2. [Q8IZP9-4]
NP_001073329.1. NM_001079860.2. [Q8IZP9-6]
NP_001171762.1. NM_001184833.1. [Q8IZP9-3]
NP_001171763.1. NM_001184834.1. [Q8IZP9-9]
NP_001171764.1. NM_001184835.1. [Q8IZP9-8]
NP_001171765.1. NM_001184836.1. [Q8IZP9-5]
NP_001171766.1. NM_001184837.1. [Q8IZP9-7]
NP_005747.2. NM_005756.3. [Q8IZP9-2]
XP_006724518.1. XM_006724455.3. [Q8IZP9-1]
XP_011543736.1. XM_011545434.1. [Q8IZP9-1]
XP_011543737.1. XM_011545435.2. [Q8IZP9-1]
UniGeneiHs.146978.

3D structure databases

ProteinModelPortaliQ8IZP9.
SMRiQ8IZP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369198.

Protein family/group databases

MEROPSiP02.007.
GPCRDBiSearch...

PTM databases

iPTMnetiQ8IZP9.
PhosphoSitePlusiQ8IZP9.

Polymorphism and mutation databases

BioMutaiGPR64.
DMDMi229462874.

Proteomic databases

MaxQBiQ8IZP9.
PaxDbiQ8IZP9.
PeptideAtlasiQ8IZP9.
PRIDEiQ8IZP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340581; ENSP00000344972; ENSG00000173698. [Q8IZP9-10]
ENST00000354791; ENSP00000346845; ENSG00000173698. [Q8IZP9-10]
ENST00000356606; ENSP00000349015; ENSG00000173698. [Q8IZP9-4]
ENST00000357544; ENSP00000350152; ENSG00000173698. [Q8IZP9-7]
ENST00000357991; ENSP00000350680; ENSG00000173698. [Q8IZP9-2]
ENST00000360279; ENSP00000353421; ENSG00000173698. [Q8IZP9-6]
ENST00000379869; ENSP00000369198; ENSG00000173698. [Q8IZP9-1]
ENST00000379873; ENSP00000369202; ENSG00000173698. [Q8IZP9-9]
ENST00000379876; ENSP00000369205; ENSG00000173698. [Q8IZP9-5]
ENST00000379878; ENSP00000369207; ENSG00000173698. [Q8IZP9-3]
GeneIDi10149.
KEGGihsa:10149.
UCSCiuc004cyx.4. human. [Q8IZP9-1]

Organism-specific databases

CTDi10149.
DisGeNETi10149.
GeneCardsiADGRG2.
H-InvDBHIX0016685.
HGNCiHGNC:4516. ADGRG2.
HPAiHPA001478.
MIMi300572. gene.
neXtProtiNX_Q8IZP9.
OpenTargetsiENSG00000173698.
PharmGKBiPA28908.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000231476.
HOVERGENiHBG051817.
InParanoidiQ8IZP9.
KOiK08451.
OMAiFIFYCVA.
OrthoDBiEOG091G00P5.
PhylomeDBiQ8IZP9.
TreeFamiTF321769.

Miscellaneous databases

GeneWikiiGPR64.
GenomeRNAii10149.
PROiQ8IZP9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173698.
GenevisibleiQ8IZP9. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZP9
Secondary accession number(s): B1AWB3
, B1AWB4, B1AWB6, B1AWB7, O00406, Q14CE0, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.