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Q8IZP9

- GPR64_HUMAN

UniProt

Q8IZP9 - GPR64_HUMAN

Protein

G-protein coupled receptor 64

Gene

GPR64

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Could be involved in a signal transduction pathway controlling epididymal function and male fertility.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc
    2. neuropeptide signaling pathway Source: InterPro
    3. spermatogenesis Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Protein family/group databases

    MEROPSiS63.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 64
    Alternative name(s):
    Human epididymis-specific protein 6
    Short name:
    He6
    Gene namesi
    Name:GPR64
    Synonyms:HE6, TM7LN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4516. GPR64.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: GDB
    4. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28908.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Chaini38 – 1017980G-protein coupled receptor 64PRO_0000012886Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi551 – 5511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi597 – 5971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1010 – 10101Phosphoserine1 Publication

    Post-translational modificationi

    Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.Curated

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8IZP9.
    PaxDbiQ8IZP9.
    PRIDEiQ8IZP9.

    PTM databases

    PhosphoSiteiQ8IZP9.

    Expressioni

    Tissue specificityi

    Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia.

    Gene expression databases

    ArrayExpressiQ8IZP9.
    BgeeiQ8IZP9.
    GenevestigatoriQ8IZP9.

    Organism-specific databases

    HPAiHPA001478.

    Interactioni

    Subunit structurei

    Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety.Curated

    Protein-protein interaction databases

    BioGridi115451. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZP9.
    SMRiQ8IZP9. Positions 631-880.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini38 – 627590ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini649 – 66719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini689 – 6935ExtracellularSequence Analysis
    Topological domaini715 – 73723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini759 – 78931ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini811 – 83424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini856 – 8572ExtracellularSequence Analysis
    Topological domaini879 – 1017139CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei628 – 64821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei668 – 68821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei694 – 71421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei738 – 75821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei790 – 81021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei835 – 85521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei858 – 87821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini567 – 61852GPSPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi672 – 6776Poly-Leu
    Compositional biasi816 – 8194Poly-Lys
    Compositional biasi925 – 9306Poly-Ser

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG051817.
    InParanoidiQ8IZP9.
    KOiK08451.
    OMAiFIFYCVA.
    OrthoDBiEOG7ZGX28.
    PhylomeDBiQ8IZP9.
    TreeFamiTF321769.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    SMARTiSM00303. GPS. 1 hit.
    [Graphical view]
    PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequences (10)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 10 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IZP9-1) [UniParc]FASTAAdd to Basket

    Also known as: Long splice variant

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP     50
    PAKLSVVSFA PSSNGTPEVE TTSLNDVTLS LLPSNETEKT KITIVKTFNA 100
    SGVKPQRNIC NLSSICNDSA FFRGEIMFQY DKESTVPQNQ HITNGTLTGV 150
    LSLSELKRSE LNKTLQTLSE TYFIMCATAE AQSTLNCTFT IKLNNTMNAC 200
    AVIAALERVK IRPMEHCCCS VRIPCPSSPE ELEKLQCDLQ DPIVCLADHP 250
    RGPPFSSSQS IPVVPRATVL SQVPKATSFA EPPDYSPVTH NVPSPIGEIQ 300
    PLSPQPSAPI ASSPAIDMPP QSETISSPMP QTHVSGTPPP VKASFSSPTV 350
    SAPANVNTTS APPVQTDIVN TSSISDLENQ VLQMEKALSL GSLEPNLAGE 400
    MINQVSRLLH SPPDMLAPLA QRLLKVVDDI GLQLNFSNTT ISLTSPSLAL 450
    AVIRVNASSF NTTTFVAQDP ANLQVSLETQ APENSIGTIT LPSSLMNNLP 500
    AHDMELASRV QFNFFETPAL FQDPSLENLS LISYVISSSV ANLTVRNLTR 550
    NVTVTLKHIN PSQDELTVRC VFWDLGRNGG RGGWSDNGCS VKDRRLNETI 600
    CTCSHLTSFG VLLDLSRTSV LPAQMMALTF ITYIGCGLSS IFLSVTLVTY 650
    IAFEKIRRDY PSKILIQLCA ALLLLNLVFL LDSWIALYKM QGLCISVAVF 700
    LHYFLLVSFT WMGLEAFHMY LALVKVFNTY IRKYILKFCI VGWGVPAVVV 750
    TIILTISPDN YGLGSYGKFP NGSPDDFCWI NNNAVFYITV VGYFCVIFLL 800
    NVSMFIVVLV QLCRIKKKKQ LGAQRKTSIQ DLRSIAGLTF LLGITWGFAF 850
    FAWGPVNVTF MYLFAIFNTL QGFFIFIFYC VAKENVRKQW RRYLCCGKLR 900
    LAENSDWSKT ATNGLKKQTV NQGVSSSSNS LQSSSNSTNS TTLLVNNDCS 950
    VHASGNGNAS TERNGVSFSV QNGDVCLHDF TGKQHMFNEK EDSCNGKGRM 1000
    ALRRTSKRGS LHFIEQM 1017
    Length:1,017
    Mass (Da):111,593
    Last modified:May 5, 2009 - v2
    Checksum:i2E0839DB45B6C553
    GO
    Isoform 2 (identifier: Q8IZP9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         65-67: Missing.

    Show »
    Length:1,014
    Mass (Da):111,337
    Checksum:i2EFFA8C485F8AB9A
    GO
    Isoform 3 (identifier: Q8IZP9-3) [UniParc]FASTAAdd to Basket

    Also known as: d1

    The sequence of this isoform differs from the canonical sequence as follows:
         51-66: Missing.

    Show »
    Length:1,001
    Mass (Da):110,049
    Checksum:i2FC89014C20F574B
    GO
    Isoform 4 (identifier: Q8IZP9-4) [UniParc]FASTAAdd to Basket

    Also known as: 24

    The sequence of this isoform differs from the canonical sequence as follows:
         88-101: Missing.

    Show »
    Length:1,003
    Mass (Da):110,031
    Checksum:i71EF3C56C15E3FDE
    GO
    Isoform 5 (identifier: Q8IZP9-5) [UniParc]FASTAAdd to Basket

    Also known as: 23

    The sequence of this isoform differs from the canonical sequence as follows:
         52-75: Missing.

    Show »
    Length:993
    Mass (Da):109,175
    Checksum:i6C0F14BEEB6BB6AD
    GO
    Isoform 6 (identifier: Q8IZP9-6) [UniParc]FASTAAdd to Basket

    Also known as: d3

    The sequence of this isoform differs from the canonical sequence as follows:
         68-101: EVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

    Show »
    Length:995
    Mass (Da):109,157
    Checksum:iC351BA0D891CA0D3
    GO
    Isoform 7 (identifier: Q8IZP9-7) [UniParc]FASTAAdd to Basket

    Also known as: d2

    The sequence of this isoform differs from the canonical sequence as follows:
         52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → EVETTSLNDVTLSLLPSNET

    Show »
    Length:987
    Mass (Da):108,487
    Checksum:iFD8CB3C2B139A78B
    GO
    Isoform 8 (identifier: Q8IZP9-8) [UniParc]FASTAAdd to Basket

    Also known as: 21

    The sequence of this isoform differs from the canonical sequence as follows:
         52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

    Show »
    Length:979
    Mass (Da):107,613
    Checksum:i49B0950AC074B2F1
    GO
    Isoform 9 (identifier: Q8IZP9-9) [UniParc]FASTAAdd to Basket

    Also known as: Delta exon 28

    The sequence of this isoform differs from the canonical sequence as follows:
         906-956: Missing.

    Show »
    Length:966
    Mass (Da):106,353
    Checksum:i042D243C632F9B35
    GO
    Isoform 10 (identifier: Q8IZP9-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         51-66: Missing.
         88-101: Missing.
         474-562: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:898
    Mass (Da):98,720
    Checksum:iE4820F94AD64A73B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021V → A in CAA57479. (PubMed:9150425)Curated
    Sequence conflicti202 – 2021V → A in AAN33056. (PubMed:12420295)Curated
    Sequence conflicti202 – 2021V → A in AAN33064. (PubMed:12420295)Curated
    Sequence conflicti202 – 2021V → A in AAN33065. (PubMed:12420295)Curated
    Sequence conflicti202 – 2021V → A in AAN38971. (PubMed:12420295)Curated
    Sequence conflicti202 – 2021V → A in AAN38972. (PubMed:12420295)Curated
    Sequence conflicti202 – 2021V → A in AAN38973. (PubMed:12420295)Curated
    Sequence conflicti202 – 2021V → A in AAN38974. (PubMed:12420295)Curated
    Sequence conflicti202 – 2021V → A in AAN75702. (PubMed:12420295)Curated
    Sequence conflicti233 – 2331E → G in CAA57479. (PubMed:9150425)Curated
    Sequence conflicti233 – 2331E → G in AAN33056. (PubMed:12420295)Curated
    Sequence conflicti233 – 2331E → G in AAN33064. (PubMed:12420295)Curated
    Sequence conflicti233 – 2331E → G in AAN33065. (PubMed:12420295)Curated
    Sequence conflicti233 – 2331E → G in AAN38971. (PubMed:12420295)Curated
    Sequence conflicti233 – 2331E → G in AAN38972. (PubMed:12420295)Curated
    Sequence conflicti233 – 2331E → G in AAN38973. (PubMed:12420295)Curated
    Sequence conflicti233 – 2331E → G in AAN38974. (PubMed:12420295)Curated
    Sequence conflicti233 – 2331E → G in AAN75702. (PubMed:12420295)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti290 – 2901H → Q.
    Corresponds to variant rs35974297 [ dbSNP | Ensembl ].
    VAR_055289
    Natural varianti771 – 7711N → S.
    Corresponds to variant rs3924227 [ dbSNP | Ensembl ].
    VAR_055290

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei51 – 6616Missing in isoform 3 and isoform 10. 2 PublicationsVSP_009792Add
    BLAST
    Alternative sequencei52 – 10150AKLSV…TFNAS → EVETTSLNDVTLSLLPSNET in isoform 7. 1 PublicationVSP_009796Add
    BLAST
    Alternative sequencei52 – 10150AKLSV…TFNAS → DVTLSLLPSNET in isoform 8. 1 PublicationVSP_009797Add
    BLAST
    Alternative sequencei52 – 7524Missing in isoform 5. 1 PublicationVSP_009794Add
    BLAST
    Alternative sequencei65 – 673Missing in isoform 2. 1 PublicationVSP_009791
    Alternative sequencei68 – 10134EVETT…TFNAS → DVTLSLLPSNET in isoform 6. 1 PublicationVSP_009795Add
    BLAST
    Alternative sequencei88 – 10114Missing in isoform 4 and isoform 10. 2 PublicationsVSP_009793Add
    BLAST
    Alternative sequencei474 – 56289Missing in isoform 10. 1 PublicationVSP_054522Add
    BLAST
    Alternative sequencei906 – 95651Missing in isoform 9. 1 PublicationVSP_009798Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81892 mRNA. Translation: CAA57479.1.
    AF538954 mRNA. Translation: AAN33056.1.
    AF539455 mRNA. Translation: AAN33064.1.
    AF539456 mRNA. Translation: AAN33065.1.
    AY143364 mRNA. Translation: AAN38971.1.
    AY143365 mRNA. Translation: AAN38972.1.
    AY143366 mRNA. Translation: AAN38973.1.
    AY143367 mRNA. Translation: AAN38974.1.
    AY148343 mRNA. Translation: AAN75702.1.
    AL732578, AL732509 Genomic DNA. Translation: CAI40668.1.
    AL732578, AL732509 Genomic DNA. Translation: CAI40669.1.
    AL732578, AL732509 Genomic DNA. Translation: CAI40670.1.
    AL732578, AL732509 Genomic DNA. Translation: CAI40671.1.
    AL732509, AL732578 Genomic DNA. Translation: CAI41675.1.
    AL732509, AL732578 Genomic DNA. Translation: CAI41676.1.
    AL732509, AL732578 Genomic DNA. Translation: CAI41677.1.
    AL732509, AL732578 Genomic DNA. Translation: CAI41678.1.
    BC113979 mRNA. Translation: AAI13980.1.
    CCDSiCCDS14191.1. [Q8IZP9-2]
    CCDS43921.1. [Q8IZP9-6]
    CCDS43922.1. [Q8IZP9-4]
    CCDS43923.1. [Q8IZP9-1]
    CCDS55376.1. [Q8IZP9-5]
    CCDS55377.1. [Q8IZP9-7]
    CCDS55378.1. [Q8IZP9-3]
    CCDS55379.1. [Q8IZP9-9]
    RefSeqiNP_001073327.1. NM_001079858.2. [Q8IZP9-1]
    NP_001073328.1. NM_001079859.2. [Q8IZP9-4]
    NP_001073329.1. NM_001079860.2. [Q8IZP9-6]
    NP_001171762.1. NM_001184833.1. [Q8IZP9-3]
    NP_001171763.1. NM_001184834.1. [Q8IZP9-9]
    NP_001171764.1. NM_001184835.1. [Q8IZP9-8]
    NP_001171765.1. NM_001184836.1. [Q8IZP9-5]
    NP_001171766.1. NM_001184837.1. [Q8IZP9-7]
    NP_005747.2. NM_005756.3. [Q8IZP9-2]
    XP_006724518.1. XM_006724455.1. [Q8IZP9-1]
    UniGeneiHs.146978.

    Genome annotation databases

    EnsembliENST00000340581; ENSP00000344972; ENSG00000173698. [Q8IZP9-10]
    ENST00000356606; ENSP00000349015; ENSG00000173698. [Q8IZP9-4]
    ENST00000357544; ENSP00000350152; ENSG00000173698. [Q8IZP9-7]
    ENST00000357991; ENSP00000350680; ENSG00000173698. [Q8IZP9-2]
    ENST00000360279; ENSP00000353421; ENSG00000173698. [Q8IZP9-6]
    ENST00000379869; ENSP00000369198; ENSG00000173698. [Q8IZP9-1]
    ENST00000379873; ENSP00000369202; ENSG00000173698. [Q8IZP9-9]
    ENST00000379876; ENSP00000369205; ENSG00000173698. [Q8IZP9-5]
    ENST00000379878; ENSP00000369207; ENSG00000173698. [Q8IZP9-3]
    GeneIDi10149.
    KEGGihsa:10149.
    UCSCiuc004cyx.3. human. [Q8IZP9-1]
    uc004cyy.3. human. [Q8IZP9-2]
    uc004cyz.3. human. [Q8IZP9-4]
    uc004cza.3. human. [Q8IZP9-6]
    uc004czb.3. human. [Q8IZP9-9]
    uc004czc.3. human. [Q8IZP9-3]
    uc004czd.3. human. [Q8IZP9-5]
    uc004cze.3. human. [Q8IZP9-7]
    uc004czf.3. human. [Q8IZP9-8]

    Polymorphism databases

    DMDMi229462874.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81892 mRNA. Translation: CAA57479.1 .
    AF538954 mRNA. Translation: AAN33056.1 .
    AF539455 mRNA. Translation: AAN33064.1 .
    AF539456 mRNA. Translation: AAN33065.1 .
    AY143364 mRNA. Translation: AAN38971.1 .
    AY143365 mRNA. Translation: AAN38972.1 .
    AY143366 mRNA. Translation: AAN38973.1 .
    AY143367 mRNA. Translation: AAN38974.1 .
    AY148343 mRNA. Translation: AAN75702.1 .
    AL732578 , AL732509 Genomic DNA. Translation: CAI40668.1 .
    AL732578 , AL732509 Genomic DNA. Translation: CAI40669.1 .
    AL732578 , AL732509 Genomic DNA. Translation: CAI40670.1 .
    AL732578 , AL732509 Genomic DNA. Translation: CAI40671.1 .
    AL732509 , AL732578 Genomic DNA. Translation: CAI41675.1 .
    AL732509 , AL732578 Genomic DNA. Translation: CAI41676.1 .
    AL732509 , AL732578 Genomic DNA. Translation: CAI41677.1 .
    AL732509 , AL732578 Genomic DNA. Translation: CAI41678.1 .
    BC113979 mRNA. Translation: AAI13980.1 .
    CCDSi CCDS14191.1. [Q8IZP9-2 ]
    CCDS43921.1. [Q8IZP9-6 ]
    CCDS43922.1. [Q8IZP9-4 ]
    CCDS43923.1. [Q8IZP9-1 ]
    CCDS55376.1. [Q8IZP9-5 ]
    CCDS55377.1. [Q8IZP9-7 ]
    CCDS55378.1. [Q8IZP9-3 ]
    CCDS55379.1. [Q8IZP9-9 ]
    RefSeqi NP_001073327.1. NM_001079858.2. [Q8IZP9-1 ]
    NP_001073328.1. NM_001079859.2. [Q8IZP9-4 ]
    NP_001073329.1. NM_001079860.2. [Q8IZP9-6 ]
    NP_001171762.1. NM_001184833.1. [Q8IZP9-3 ]
    NP_001171763.1. NM_001184834.1. [Q8IZP9-9 ]
    NP_001171764.1. NM_001184835.1. [Q8IZP9-8 ]
    NP_001171765.1. NM_001184836.1. [Q8IZP9-5 ]
    NP_001171766.1. NM_001184837.1. [Q8IZP9-7 ]
    NP_005747.2. NM_005756.3. [Q8IZP9-2 ]
    XP_006724518.1. XM_006724455.1. [Q8IZP9-1 ]
    UniGenei Hs.146978.

    3D structure databases

    ProteinModelPortali Q8IZP9.
    SMRi Q8IZP9. Positions 631-880.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115451. 1 interaction.

    Protein family/group databases

    MEROPSi S63.010.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8IZP9.

    Polymorphism databases

    DMDMi 229462874.

    Proteomic databases

    MaxQBi Q8IZP9.
    PaxDbi Q8IZP9.
    PRIDEi Q8IZP9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340581 ; ENSP00000344972 ; ENSG00000173698 . [Q8IZP9-10 ]
    ENST00000356606 ; ENSP00000349015 ; ENSG00000173698 . [Q8IZP9-4 ]
    ENST00000357544 ; ENSP00000350152 ; ENSG00000173698 . [Q8IZP9-7 ]
    ENST00000357991 ; ENSP00000350680 ; ENSG00000173698 . [Q8IZP9-2 ]
    ENST00000360279 ; ENSP00000353421 ; ENSG00000173698 . [Q8IZP9-6 ]
    ENST00000379869 ; ENSP00000369198 ; ENSG00000173698 . [Q8IZP9-1 ]
    ENST00000379873 ; ENSP00000369202 ; ENSG00000173698 . [Q8IZP9-9 ]
    ENST00000379876 ; ENSP00000369205 ; ENSG00000173698 . [Q8IZP9-5 ]
    ENST00000379878 ; ENSP00000369207 ; ENSG00000173698 . [Q8IZP9-3 ]
    GeneIDi 10149.
    KEGGi hsa:10149.
    UCSCi uc004cyx.3. human. [Q8IZP9-1 ]
    uc004cyy.3. human. [Q8IZP9-2 ]
    uc004cyz.3. human. [Q8IZP9-4 ]
    uc004cza.3. human. [Q8IZP9-6 ]
    uc004czb.3. human. [Q8IZP9-9 ]
    uc004czc.3. human. [Q8IZP9-3 ]
    uc004czd.3. human. [Q8IZP9-5 ]
    uc004cze.3. human. [Q8IZP9-7 ]
    uc004czf.3. human. [Q8IZP9-8 ]

    Organism-specific databases

    CTDi 10149.
    GeneCardsi GC0XM019007.
    H-InvDB HIX0016685.
    HGNCi HGNC:4516. GPR64.
    HPAi HPA001478.
    MIMi 300572. gene.
    neXtProti NX_Q8IZP9.
    PharmGKBi PA28908.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG051817.
    InParanoidi Q8IZP9.
    KOi K08451.
    OMAi FIFYCVA.
    OrthoDBi EOG7ZGX28.
    PhylomeDBi Q8IZP9.
    TreeFami TF321769.

    Miscellaneous databases

    GeneWikii GPR64.
    GenomeRNAii 10149.
    NextBioi 38407.
    PROi Q8IZP9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZP9.
    Bgeei Q8IZP9.
    Genevestigatori Q8IZP9.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    SMARTi SM00303. GPS. 1 hit.
    [Graphical view ]
    PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily."
      Osterhoff C., Ivell R., Kirchhoff C.
      DNA Cell Biol. 16:379-389(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Epididymis.
    2. "HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia."
      Obermann H., Samalecos A., Osterhoff C., Schroeder B., Heller R., Kirchhoff C.
      Mol. Reprod. Dev. 64:13-26(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6; 7; 8 AND 9).
      Tissue: Epididymis.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10).
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiGPR64_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZP9
    Secondary accession number(s): B1AWB3
    , B1AWB4, B1AWB6, B1AWB7, O00406, Q14CE0, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3