Q8IZP9 (GPR64_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor 64

Alternative name(s):
Human epididymis-specific protein 6
Short name=He6

Gene names

Name:	GPR64
Synonyms:	HE6, TM7LN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1017 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Could be involved in a signal transduction pathway controlling epididymal function and male fertility.
Subunit structure	Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety Probable.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia.
Post-translational modification	Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit Potential.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro spermatogenesis Traceable author statement Ref.1. Source: ProtInc
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara cytoplasm Inferred from direct assay. Source: HPA integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZP9-1)

Also known as: Long splice variant;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZP9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     65-67: Missing.

Isoform 3 (identifier: Q8IZP9-3)

Also known as: d1;

The sequence of this isoform differs from the canonical sequence as follows:
     51-66: Missing.

Isoform 4 (identifier: Q8IZP9-4)

Also known as: 24;

The sequence of this isoform differs from the canonical sequence as follows:
     88-101: Missing.

Isoform 5 (identifier: Q8IZP9-5)

Also known as: 23;

The sequence of this isoform differs from the canonical sequence as follows:
     52-75: Missing.

Isoform 6 (identifier: Q8IZP9-6)

Also known as: d3;

The sequence of this isoform differs from the canonical sequence as follows:
     68-101: EVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

Isoform 7 (identifier: Q8IZP9-7)

Also known as: d2;

The sequence of this isoform differs from the canonical sequence as follows:
     52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → EVETTSLNDVTLSLLPSNET

Isoform 8 (identifier: Q8IZP9-8)

Also known as: 21;

The sequence of this isoform differs from the canonical sequence as follows:
     52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

Isoform 9 (identifier: Q8IZP9-9)

Also known as: Delta exon 28;

The sequence of this isoform differs from the canonical sequence as follows:
     906-956: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Chain	38 – 1017	980	G-protein coupled receptor 64		PRO_0000012886
Regions
	Topological domain	38 – 627	590	Extracellular Potential
	Transmembrane	628 – 648	21	Helical; Name=1; Potential
	Topological domain	649 – 667	19	Cytoplasmic Potential
	Transmembrane	668 – 688	21	Helical; Name=2; Potential
	Topological domain	689 – 693	5	Extracellular Potential
	Transmembrane	694 – 714	21	Helical; Name=3; Potential
	Topological domain	715 – 737	23	Cytoplasmic Potential
	Transmembrane	738 – 758	21	Helical; Name=4; Potential
	Topological domain	759 – 789	31	Extracellular Potential
	Transmembrane	790 – 810	21	Helical; Name=5; Potential
	Topological domain	811 – 834	24	Cytoplasmic Potential
	Transmembrane	835 – 855	21	Helical; Name=6; Potential
	Topological domain	856 – 857	2	Extracellular Potential
	Transmembrane	858 – 878	21	Helical; Name=7; Potential
	Topological domain	879 – 1017	139	Cytoplasmic Potential
	Domain	567 – 618	52	GPS
	Compositional bias	672 – 677	6	Poly-Leu
	Compositional bias	816 – 819	4	Poly-Lys
	Compositional bias	925 – 930	6	Poly-Ser
Amino acid modifications
	Modified residue	1010	1	Phosphoserine Ref.5
	Glycosylation	44	1	N-linked (GlcNAc...) Potential
	Glycosylation	85	1	N-linked (GlcNAc...) Potential
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	117	1	N-linked (GlcNAc...) Potential
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Glycosylation	162	1	N-linked (GlcNAc...) Potential
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Glycosylation	194	1	N-linked (GlcNAc...) Potential
	Glycosylation	357	1	N-linked (GlcNAc...) Potential
	Glycosylation	370	1	N-linked (GlcNAc...) Potential
	Glycosylation	435	1	N-linked (GlcNAc...) Potential
	Glycosylation	438	1	N-linked (GlcNAc...) Potential
	Glycosylation	456	1	N-linked (GlcNAc...) Potential
	Glycosylation	461	1	N-linked (GlcNAc...) Potential
	Glycosylation	528	1	N-linked (GlcNAc...) Potential
	Glycosylation	542	1	N-linked (GlcNAc...) Potential
	Glycosylation	547	1	N-linked (GlcNAc...) Potential
	Glycosylation	551	1	N-linked (GlcNAc...) Potential
	Glycosylation	597	1	N-linked (GlcNAc...) Potential
	Glycosylation	857	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	51 – 66	16	Missing in isoform 3.		VSP_009792
	Alternative sequence	52 – 101	50	AKLSV…TFNAS → EVETTSLNDVTLSLLPSNET in isoform 7.		VSP_009796
	Alternative sequence	52 – 101	50	AKLSV…TFNAS → DVTLSLLPSNET in isoform 8.		VSP_009797
	Alternative sequence	52 – 75	24	Missing in isoform 5.		VSP_009794
	Alternative sequence	65 – 67	3	Missing in isoform 2.		VSP_009791
	Alternative sequence	68 – 101	34	EVETT…TFNAS → DVTLSLLPSNET in isoform 6.		VSP_009795
	Alternative sequence	88 – 101	14	Missing in isoform 4.		VSP_009793
	Alternative sequence	906 – 956	51	Missing in isoform 9.		VSP_009798
	Natural variant	290	1	H → Q. Corresponds to variant rs35974297 [ dbSNP | Ensembl ].		VAR_055289
	Natural variant	771	1	N → S. Corresponds to variant rs3924227 [ dbSNP | Ensembl ].		VAR_055290
Experimental info
	Sequence conflict	202	1	V → A in CAA57479. Ref.1
	Sequence conflict	202	1	V → A in AAN33056. Ref.2
	Sequence conflict	202	1	V → A in AAN33064. Ref.2
	Sequence conflict	202	1	V → A in AAN33065. Ref.2
	Sequence conflict	202	1	V → A in AAN38971. Ref.2
	Sequence conflict	202	1	V → A in AAN38972. Ref.2
	Sequence conflict	202	1	V → A in AAN38973. Ref.2
	Sequence conflict	202	1	V → A in AAN38974. Ref.2
	Sequence conflict	202	1	V → A in AAN75702. Ref.2
	Sequence conflict	233	1	E → G in CAA57479. Ref.1
	Sequence conflict	233	1	E → G in AAN33056. Ref.2
	Sequence conflict	233	1	E → G in AAN33064. Ref.2
	Sequence conflict	233	1	E → G in AAN33065. Ref.2
	Sequence conflict	233	1	E → G in AAN38971. Ref.2
	Sequence conflict	233	1	E → G in AAN38972. Ref.2
	Sequence conflict	233	1	E → G in AAN38973. Ref.2
	Sequence conflict	233	1	E → G in AAN38974. Ref.2
	Sequence conflict	233	1	E → G in AAN75702. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long splice variant) [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 2E0839DB45B6C553	FASTA	1,017	111,593
	10 20 30 40 50 60 MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PAKLSVVSFA 70 80 90 100 110 120 PSSNGTPEVE TTSLNDVTLS LLPSNETEKT KITIVKTFNA SGVKPQRNIC NLSSICNDSA 130 140 150 160 170 180 FFRGEIMFQY DKESTVPQNQ HITNGTLTGV LSLSELKRSE LNKTLQTLSE TYFIMCATAE 190 200 210 220 230 240 AQSTLNCTFT IKLNNTMNAC AVIAALERVK IRPMEHCCCS VRIPCPSSPE ELEKLQCDLQ 250 260 270 280 290 300 DPIVCLADHP RGPPFSSSQS IPVVPRATVL SQVPKATSFA EPPDYSPVTH NVPSPIGEIQ 310 320 330 340 350 360 PLSPQPSAPI ASSPAIDMPP QSETISSPMP QTHVSGTPPP VKASFSSPTV SAPANVNTTS 370 380 390 400 410 420 APPVQTDIVN TSSISDLENQ VLQMEKALSL GSLEPNLAGE MINQVSRLLH SPPDMLAPLA 430 440 450 460 470 480 QRLLKVVDDI GLQLNFSNTT ISLTSPSLAL AVIRVNASSF NTTTFVAQDP ANLQVSLETQ 490 500 510 520 530 540 APENSIGTIT LPSSLMNNLP AHDMELASRV QFNFFETPAL FQDPSLENLS LISYVISSSV 550 560 570 580 590 600 ANLTVRNLTR NVTVTLKHIN PSQDELTVRC VFWDLGRNGG RGGWSDNGCS VKDRRLNETI 610 620 630 640 650 660 CTCSHLTSFG VLLDLSRTSV LPAQMMALTF ITYIGCGLSS IFLSVTLVTY IAFEKIRRDY 670 680 690 700 710 720 PSKILIQLCA ALLLLNLVFL LDSWIALYKM QGLCISVAVF LHYFLLVSFT WMGLEAFHMY 730 740 750 760 770 780 LALVKVFNTY IRKYILKFCI VGWGVPAVVV TIILTISPDN YGLGSYGKFP NGSPDDFCWI 790 800 810 820 830 840 NNNAVFYITV VGYFCVIFLL NVSMFIVVLV QLCRIKKKKQ LGAQRKTSIQ DLRSIAGLTF 850 860 870 880 890 900 LLGITWGFAF FAWGPVNVTF MYLFAIFNTL QGFFIFIFYC VAKENVRKQW RRYLCCGKLR 910 920 930 940 950 960 LAENSDWSKT ATNGLKKQTV NQGVSSSSNS LQSSSNSTNS TTLLVNNDCS VHASGNGNAS 970 980 990 1000 1010 TERNGVSFSV QNGDVCLHDF TGKQHMFNEK EDSCNGKGRM ALRRTSKRGS LHFIEQM
	Isoform 2 [UniParc]. Checksum: 2EFFA8C485F8AB9A	FASTA	1,014	111,337
	10 20 30 40 50 60 MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PAKLSVVSFA 70 80 90 100 110 120 PSSNEVETTS LNDVTLSLLP SNETEKTKIT IVKTFNASGV KPQRNICNLS SICNDSAFFR 130 140 150 160 170 180 GEIMFQYDKE STVPQNQHIT NGTLTGVLSL SELKRSELNK TLQTLSETYF IMCATAEAQS 190 200 210 220 230 240 TLNCTFTIKL NNTMNACAVI AALERVKIRP MEHCCCSVRI PCPSSPEELE KLQCDLQDPI 250 260 270 280 290 300 VCLADHPRGP PFSSSQSIPV VPRATVLSQV PKATSFAEPP DYSPVTHNVP SPIGEIQPLS 310 320 330 340 350 360 PQPSAPIASS PAIDMPPQSE TISSPMPQTH VSGTPPPVKA SFSSPTVSAP ANVNTTSAPP 370 380 390 400 410 420 VQTDIVNTSS ISDLENQVLQ MEKALSLGSL EPNLAGEMIN QVSRLLHSPP DMLAPLAQRL 430 440 450 460 470 480 LKVVDDIGLQ LNFSNTTISL TSPSLALAVI RVNASSFNTT TFVAQDPANL QVSLETQAPE 490 500 510 520 530 540 NSIGTITLPS SLMNNLPAHD MELASRVQFN FFETPALFQD PSLENLSLIS YVISSSVANL 550 560 570 580 590 600 TVRNLTRNVT VTLKHINPSQ DELTVRCVFW DLGRNGGRGG WSDNGCSVKD RRLNETICTC 610 620 630 640 650 660 SHLTSFGVLL DLSRTSVLPA QMMALTFITY IGCGLSSIFL SVTLVTYIAF EKIRRDYPSK 670 680 690 700 710 720 ILIQLCAALL LLNLVFLLDS WIALYKMQGL CISVAVFLHY FLLVSFTWMG LEAFHMYLAL 730 740 750 760 770 780 VKVFNTYIRK YILKFCIVGW GVPAVVVTII LTISPDNYGL GSYGKFPNGS PDDFCWINNN 790 800 810 820 830 840 AVFYITVVGY FCVIFLLNVS MFIVVLVQLC RIKKKKQLGA QRKTSIQDLR SIAGLTFLLG 850 860 870 880 890 900 ITWGFAFFAW GPVNVTFMYL FAIFNTLQGF FIFIFYCVAK ENVRKQWRRY LCCGKLRLAE 910 920 930 940 950 960 NSDWSKTATN GLKKQTVNQG VSSSSNSLQS SSNSTNSTTL LVNNDCSVHA SGNGNASTER 970 980 990 1000 1010 NGVSFSVQNG DVCLHDFTGK QHMFNEKEDS CNGKGRMALR RTSKRGSLHF IEQM
	Isoform 3 (d1) [UniParc]. Checksum: 2FC89014C20F574B	FASTA	1,001	110,049
	10 20 30 40 50 60 MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PEVETTSLND 70 80 90 100 110 120 VTLSLLPSNE TEKTKITIVK TFNASGVKPQ RNICNLSSIC NDSAFFRGEI MFQYDKESTV 130 140 150 160 170 180 PQNQHITNGT LTGVLSLSEL KRSELNKTLQ TLSETYFIMC ATAEAQSTLN CTFTIKLNNT 190 200 210 220 230 240 MNACAVIAAL ERVKIRPMEH CCCSVRIPCP SSPEELEKLQ CDLQDPIVCL ADHPRGPPFS 250 260 270 280 290 300 SSQSIPVVPR ATVLSQVPKA TSFAEPPDYS PVTHNVPSPI GEIQPLSPQP SAPIASSPAI 310 320 330 340 350 360 DMPPQSETIS SPMPQTHVSG TPPPVKASFS SPTVSAPANV NTTSAPPVQT DIVNTSSISD 370 380 390 400 410 420 LENQVLQMEK ALSLGSLEPN LAGEMINQVS RLLHSPPDML APLAQRLLKV VDDIGLQLNF 430 440 450 460 470 480 SNTTISLTSP SLALAVIRVN ASSFNTTTFV AQDPANLQVS LETQAPENSI GTITLPSSLM 490 500 510 520 530 540 NNLPAHDMEL ASRVQFNFFE TPALFQDPSL ENLSLISYVI SSSVANLTVR NLTRNVTVTL 550 560 570 580 590 600 KHINPSQDEL TVRCVFWDLG RNGGRGGWSD NGCSVKDRRL NETICTCSHL TSFGVLLDLS 610 620 630 640 650 660 RTSVLPAQMM ALTFITYIGC GLSSIFLSVT LVTYIAFEKI RRDYPSKILI QLCAALLLLN 670 680 690 700 710 720 LVFLLDSWIA LYKMQGLCIS VAVFLHYFLL VSFTWMGLEA FHMYLALVKV FNTYIRKYIL 730 740 750 760 770 780 KFCIVGWGVP AVVVTIILTI SPDNYGLGSY GKFPNGSPDD FCWINNNAVF YITVVGYFCV 790 800 810 820 830 840 IFLLNVSMFI VVLVQLCRIK KKKQLGAQRK TSIQDLRSIA GLTFLLGITW GFAFFAWGPV 850 860 870 880 890 900 NVTFMYLFAI FNTLQGFFIF IFYCVAKENV RKQWRRYLCC GKLRLAENSD WSKTATNGLK 910 920 930 940 950 960 KQTVNQGVSS SSNSLQSSSN STNSTTLLVN NDCSVHASGN GNASTERNGV SFSVQNGDVC 970 980 990 1000 LHDFTGKQHM FNEKEDSCNG KGRMALRRTS KRGSLHFIEQ M
	Isoform 4 (24) [UniParc]. Checksum: 71EF3C56C15E3FDE	FASTA	1,003	110,031
	10 20 30 40 50 60 MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PAKLSVVSFA 70 80 90 100 110 120 PSSNGTPEVE TTSLNDVTLS LLPSNETGVK PQRNICNLSS ICNDSAFFRG EIMFQYDKES 130 140 150 160 170 180 TVPQNQHITN GTLTGVLSLS ELKRSELNKT LQTLSETYFI MCATAEAQST LNCTFTIKLN 190 200 210 220 230 240 NTMNACAVIA ALERVKIRPM EHCCCSVRIP CPSSPEELEK LQCDLQDPIV CLADHPRGPP 250 260 270 280 290 300 FSSSQSIPVV PRATVLSQVP KATSFAEPPD YSPVTHNVPS PIGEIQPLSP QPSAPIASSP 310 320 330 340 350 360 AIDMPPQSET ISSPMPQTHV SGTPPPVKAS FSSPTVSAPA NVNTTSAPPV QTDIVNTSSI 370 380 390 400 410 420 SDLENQVLQM EKALSLGSLE PNLAGEMINQ VSRLLHSPPD MLAPLAQRLL KVVDDIGLQL 430 440 450 460 470 480 NFSNTTISLT SPSLALAVIR VNASSFNTTT FVAQDPANLQ VSLETQAPEN SIGTITLPSS 490 500 510 520 530 540 LMNNLPAHDM ELASRVQFNF FETPALFQDP SLENLSLISY VISSSVANLT VRNLTRNVTV 550 560 570 580 590 600 TLKHINPSQD ELTVRCVFWD LGRNGGRGGW SDNGCSVKDR RLNETICTCS HLTSFGVLLD 610 620 630 640 650 660 LSRTSVLPAQ MMALTFITYI GCGLSSIFLS VTLVTYIAFE KIRRDYPSKI LIQLCAALLL 670 680 690 700 710 720 LNLVFLLDSW IALYKMQGLC ISVAVFLHYF LLVSFTWMGL EAFHMYLALV KVFNTYIRKY 730 740 750 760 770 780 ILKFCIVGWG VPAVVVTIIL TISPDNYGLG SYGKFPNGSP DDFCWINNNA VFYITVVGYF 790 800 810 820 830 840 CVIFLLNVSM FIVVLVQLCR IKKKKQLGAQ RKTSIQDLRS IAGLTFLLGI TWGFAFFAWG 850 860 870 880 890 900 PVNVTFMYLF AIFNTLQGFF IFIFYCVAKE NVRKQWRRYL CCGKLRLAEN SDWSKTATNG 910 920 930 940 950 960 LKKQTVNQGV SSSSNSLQSS SNSTNSTTLL VNNDCSVHAS GNGNASTERN GVSFSVQNGD 970 980 990 1000 VCLHDFTGKQ HMFNEKEDSC NGKGRMALRR TSKRGSLHFI EQM
	Isoform 5 (23) [UniParc]. Checksum: 6C0F14BEEB6BB6AD	FASTA	993	109,175
	10 20 30 40 50 60 MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PDVTLSLLPS 70 80 90 100 110 120 NETEKTKITI VKTFNASGVK PQRNICNLSS ICNDSAFFRG EIMFQYDKES TVPQNQHITN 130 140 150 160 170 180 GTLTGVLSLS ELKRSELNKT LQTLSETYFI MCATAEAQST LNCTFTIKLN NTMNACAVIA 190 200 210 220 230 240 ALERVKIRPM EHCCCSVRIP CPSSPEELEK LQCDLQDPIV CLADHPRGPP FSSSQSIPVV 250 260 270 280 290 300 PRATVLSQVP KATSFAEPPD YSPVTHNVPS PIGEIQPLSP QPSAPIASSP AIDMPPQSET 310 320 330 340 350 360 ISSPMPQTHV SGTPPPVKAS FSSPTVSAPA NVNTTSAPPV QTDIVNTSSI SDLENQVLQM 370 380 390 400 410 420 EKALSLGSLE PNLAGEMINQ VSRLLHSPPD MLAPLAQRLL KVVDDIGLQL NFSNTTISLT 430 440 450 460 470 480 SPSLALAVIR VNASSFNTTT FVAQDPANLQ VSLETQAPEN SIGTITLPSS LMNNLPAHDM 490 500 510 520 530 540 ELASRVQFNF FETPALFQDP SLENLSLISY VISSSVANLT VRNLTRNVTV TLKHINPSQD 550 560 570 580 590 600 ELTVRCVFWD LGRNGGRGGW SDNGCSVKDR RLNETICTCS HLTSFGVLLD LSRTSVLPAQ 610 620 630 640 650 660 MMALTFITYI GCGLSSIFLS VTLVTYIAFE KIRRDYPSKI LIQLCAALLL LNLVFLLDSW 670 680 690 700 710 720 IALYKMQGLC ISVAVFLHYF LLVSFTWMGL EAFHMYLALV KVFNTYIRKY ILKFCIVGWG 730 740 750 760 770 780 VPAVVVTIIL TISPDNYGLG SYGKFPNGSP DDFCWINNNA VFYITVVGYF CVIFLLNVSM 790 800 810 820 830 840 FIVVLVQLCR IKKKKQLGAQ RKTSIQDLRS IAGLTFLLGI TWGFAFFAWG PVNVTFMYLF 850 860 870 880 890 900 AIFNTLQGFF IFIFYCVAKE NVRKQWRRYL CCGKLRLAEN SDWSKTATNG LKKQTVNQGV 910 920 930 940 950 960 SSSSNSLQSS SNSTNSTTLL VNNDCSVHAS GNGNASTERN GVSFSVQNGD VCLHDFTGKQ 970 980 990 HMFNEKEDSC NGKGRMALRR TSKRGSLHFI EQM
	Isoform 6 (d3) [UniParc]. Checksum: C351BA0D891CA0D3	FASTA	995	109,157
	10 20 30 40 50 60 MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PAKLSVVSFA 70 80 90 100 110 120 PSSNGTPDVT LSLLPSNETG VKPQRNICNL SSICNDSAFF RGEIMFQYDK ESTVPQNQHI 130 140 150 160 170 180 TNGTLTGVLS LSELKRSELN KTLQTLSETY FIMCATAEAQ STLNCTFTIK LNNTMNACAV 190 200 210 220 230 240 IAALERVKIR PMEHCCCSVR IPCPSSPEEL EKLQCDLQDP IVCLADHPRG PPFSSSQSIP 250 260 270 280 290 300 VVPRATVLSQ VPKATSFAEP PDYSPVTHNV PSPIGEIQPL SPQPSAPIAS SPAIDMPPQS 310 320 330 340 350 360 ETISSPMPQT HVSGTPPPVK ASFSSPTVSA PANVNTTSAP PVQTDIVNTS SISDLENQVL 370 380 390 400 410 420 QMEKALSLGS LEPNLAGEMI NQVSRLLHSP PDMLAPLAQR LLKVVDDIGL QLNFSNTTIS 430 440 450 460 470 480 LTSPSLALAV IRVNASSFNT TTFVAQDPAN LQVSLETQAP ENSIGTITLP SSLMNNLPAH 490 500 510 520 530 540 DMELASRVQF NFFETPALFQ DPSLENLSLI SYVISSSVAN LTVRNLTRNV TVTLKHINPS 550 560 570 580 590 600 QDELTVRCVF WDLGRNGGRG GWSDNGCSVK DRRLNETICT CSHLTSFGVL LDLSRTSVLP 610 620 630 640 650 660 AQMMALTFIT YIGCGLSSIF LSVTLVTYIA FEKIRRDYPS KILIQLCAAL LLLNLVFLLD 670 680 690 700 710 720 SWIALYKMQG LCISVAVFLH YFLLVSFTWM GLEAFHMYLA LVKVFNTYIR KYILKFCIVG 730 740 750 760 770 780 WGVPAVVVTI ILTISPDNYG LGSYGKFPNG SPDDFCWINN NAVFYITVVG YFCVIFLLNV 790 800 810 820 830 840 SMFIVVLVQL CRIKKKKQLG AQRKTSIQDL RSIAGLTFLL GITWGFAFFA WGPVNVTFMY 850 860 870 880 890 900 LFAIFNTLQG FFIFIFYCVA KENVRKQWRR YLCCGKLRLA ENSDWSKTAT NGLKKQTVNQ 910 920 930 940 950 960 GVSSSSNSLQ SSSNSTNSTT LLVNNDCSVH ASGNGNASTE RNGVSFSVQN GDVCLHDFTG 970 980 990 KQHMFNEKED SCNGKGRMAL RRTSKRGSLH FIEQM
	Isoform 7 (d2) [UniParc]. Checksum: FD8CB3C2B139A78B	FASTA	987	108,487
	10 20 30 40 50 60 MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PEVETTSLND 70 80 90 100 110 120 VTLSLLPSNE TGVKPQRNIC NLSSICNDSA FFRGEIMFQY DKESTVPQNQ HITNGTLTGV 130 140 150 160 170 180 LSLSELKRSE LNKTLQTLSE TYFIMCATAE AQSTLNCTFT IKLNNTMNAC AVIAALERVK 190 200 210 220 230 240 IRPMEHCCCS VRIPCPSSPE ELEKLQCDLQ DPIVCLADHP RGPPFSSSQS IPVVPRATVL 250 260 270 280 290 300 SQVPKATSFA EPPDYSPVTH NVPSPIGEIQ PLSPQPSAPI ASSPAIDMPP QSETISSPMP 310 320 330 340 350 360 QTHVSGTPPP VKASFSSPTV SAPANVNTTS APPVQTDIVN TSSISDLENQ VLQMEKALSL 370 380 390 400 410 420 GSLEPNLAGE MINQVSRLLH SPPDMLAPLA QRLLKVVDDI GLQLNFSNTT ISLTSPSLAL 430 440 450 460 470 480 AVIRVNASSF NTTTFVAQDP ANLQVSLETQ APENSIGTIT LPSSLMNNLP AHDMELASRV 490 500 510 520 530 540 QFNFFETPAL FQDPSLENLS LISYVISSSV ANLTVRNLTR NVTVTLKHIN PSQDELTVRC 550 560 570 580 590 600 VFWDLGRNGG RGGWSDNGCS VKDRRLNETI CTCSHLTSFG VLLDLSRTSV LPAQMMALTF 610 620 630 640 650 660 ITYIGCGLSS IFLSVTLVTY IAFEKIRRDY PSKILIQLCA ALLLLNLVFL LDSWIALYKM 670 680 690 700 710 720 QGLCISVAVF LHYFLLVSFT WMGLEAFHMY LALVKVFNTY IRKYILKFCI VGWGVPAVVV 730 740 750 760 770 780 TIILTISPDN YGLGSYGKFP NGSPDDFCWI NNNAVFYITV VGYFCVIFLL NVSMFIVVLV 790 800 810 820 830 840 QLCRIKKKKQ LGAQRKTSIQ DLRSIAGLTF LLGITWGFAF FAWGPVNVTF MYLFAIFNTL 850 860 870 880 890 900 QGFFIFIFYC VAKENVRKQW RRYLCCGKLR LAENSDWSKT ATNGLKKQTV NQGVSSSSNS 910 920 930 940 950 960 LQSSSNSTNS TTLLVNNDCS VHASGNGNAS TERNGVSFSV QNGDVCLHDF TGKQHMFNEK 970 980 EDSCNGKGRM ALRRTSKRGS LHFIEQM
	Isoform 8 (21) [UniParc]. Checksum: 49B0950AC074B2F1	FASTA	979	107,613
	10 20 30 40 50 60 MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PDVTLSLLPS 70 80 90 100 110 120 NETGVKPQRN ICNLSSICND SAFFRGEIMF QYDKESTVPQ NQHITNGTLT GVLSLSELKR 130 140 150 160 170 180 SELNKTLQTL SETYFIMCAT AEAQSTLNCT FTIKLNNTMN ACAVIAALER VKIRPMEHCC 190 200 210 220 230 240 CSVRIPCPSS PEELEKLQCD LQDPIVCLAD HPRGPPFSSS QSIPVVPRAT VLSQVPKATS 250 260 270 280 290 300 FAEPPDYSPV THNVPSPIGE IQPLSPQPSA PIASSPAIDM PPQSETISSP MPQTHVSGTP 310 320 330 340 350 360 PPVKASFSSP TVSAPANVNT TSAPPVQTDI VNTSSISDLE NQVLQMEKAL SLGSLEPNLA 370 380 390 400 410 420 GEMINQVSRL LHSPPDMLAP LAQRLLKVVD DIGLQLNFSN TTISLTSPSL ALAVIRVNAS 430 440 450 460 470 480 SFNTTTFVAQ DPANLQVSLE TQAPENSIGT ITLPSSLMNN LPAHDMELAS RVQFNFFETP 490 500 510 520 530 540 ALFQDPSLEN LSLISYVISS SVANLTVRNL TRNVTVTLKH INPSQDELTV RCVFWDLGRN 550 560 570 580 590 600 GGRGGWSDNG CSVKDRRLNE TICTCSHLTS FGVLLDLSRT SVLPAQMMAL TFITYIGCGL 610 620 630 640 650 660 SSIFLSVTLV TYIAFEKIRR DYPSKILIQL CAALLLLNLV FLLDSWIALY KMQGLCISVA 670 680 690 700 710 720 VFLHYFLLVS FTWMGLEAFH MYLALVKVFN TYIRKYILKF CIVGWGVPAV VVTIILTISP 730 740 750 760 770 780 DNYGLGSYGK FPNGSPDDFC WINNNAVFYI TVVGYFCVIF LLNVSMFIVV LVQLCRIKKK 790 800 810 820 830 840 KQLGAQRKTS IQDLRSIAGL TFLLGITWGF AFFAWGPVNV TFMYLFAIFN TLQGFFIFIF 850 860 870 880 890 900 YCVAKENVRK QWRRYLCCGK LRLAENSDWS KTATNGLKKQ TVNQGVSSSS NSLQSSSNST 910 920 930 940 950 960 NSTTLLVNND CSVHASGNGN ASTERNGVSF SVQNGDVCLH DFTGKQHMFN EKEDSCNGKG 970 RMALRRTSKR GSLHFIEQM
	Isoform 9 (Delta exon 28) [UniParc]. Checksum: 042D243C632F9B35	FASTA	966	106,353
	10 20 30 40 50 60 MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PAKLSVVSFA 70 80 90 100 110 120 PSSNGTPEVE TTSLNDVTLS LLPSNETEKT KITIVKTFNA SGVKPQRNIC NLSSICNDSA 130 140 150 160 170 180 FFRGEIMFQY DKESTVPQNQ HITNGTLTGV LSLSELKRSE LNKTLQTLSE TYFIMCATAE 190 200 210 220 230 240 AQSTLNCTFT IKLNNTMNAC AVIAALERVK IRPMEHCCCS VRIPCPSSPE ELEKLQCDLQ 250 260 270 280 290 300 DPIVCLADHP RGPPFSSSQS IPVVPRATVL SQVPKATSFA EPPDYSPVTH NVPSPIGEIQ 310 320 330 340 350 360 PLSPQPSAPI ASSPAIDMPP QSETISSPMP QTHVSGTPPP VKASFSSPTV SAPANVNTTS 370 380 390 400 410 420 APPVQTDIVN TSSISDLENQ VLQMEKALSL GSLEPNLAGE MINQVSRLLH SPPDMLAPLA 430 440 450 460 470 480 QRLLKVVDDI GLQLNFSNTT ISLTSPSLAL AVIRVNASSF NTTTFVAQDP ANLQVSLETQ 490 500 510 520 530 540 APENSIGTIT LPSSLMNNLP AHDMELASRV QFNFFETPAL FQDPSLENLS LISYVISSSV 550 560 570 580 590 600 ANLTVRNLTR NVTVTLKHIN PSQDELTVRC VFWDLGRNGG RGGWSDNGCS VKDRRLNETI 610 620 630 640 650 660 CTCSHLTSFG VLLDLSRTSV LPAQMMALTF ITYIGCGLSS IFLSVTLVTY IAFEKIRRDY 670 680 690 700 710 720 PSKILIQLCA ALLLLNLVFL LDSWIALYKM QGLCISVAVF LHYFLLVSFT WMGLEAFHMY 730 740 750 760 770 780 LALVKVFNTY IRKYILKFCI VGWGVPAVVV TIILTISPDN YGLGSYGKFP NGSPDDFCWI 790 800 810 820 830 840 NNNAVFYITV VGYFCVIFLL NVSMFIVVLV QLCRIKKKKQ LGAQRKTSIQ DLRSIAGLTF 850 860 870 880 890 900 LLGITWGFAF FAWGPVNVTF MYLFAIFNTL QGFFIFIFYC VAKENVRKQW RRYLCCGKLR 910 920 930 940 950 960 LAENSGNAST ERNGVSFSVQ NGDVCLHDFT GKQHMFNEKE DSCNGKGRMA LRRTSKRGSL HFIEQM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily." Osterhoff C., Ivell R., Kirchhoff C. DNA Cell Biol. 16:379-389(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Epididymis.
[2]	"HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia." Obermann H., Samalecos A., Osterhoff C., Schroeder B., Heller R., Kirchhoff C. Mol. Reprod. Dev. 64:13-26(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6; 7; 8 AND 9). Tissue: Epididymis.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X81892 mRNA. Translation: CAA57479.1. AF538954 mRNA. Translation: AAN33056.1. AF539455 mRNA. Translation: AAN33064.1. AF539456 mRNA. Translation: AAN33065.1. AY143364 mRNA. Translation: AAN38971.1. AY143365 mRNA. Translation: AAN38972.1. AY143366 mRNA. Translation: AAN38973.1. AY143367 mRNA. Translation: AAN38974.1. AY148343 mRNA. Translation: AAN75702.1. AL732578, AL732509 Genomic DNA. Translation: CAI40668.1. AL732578, AL732509 Genomic DNA. Translation: CAI40669.1. AL732578, AL732509 Genomic DNA. Translation: CAI40670.1. AL732578, AL732509 Genomic DNA. Translation: CAI40671.1. AL732509, AL732578 Genomic DNA. Translation: CAI41675.1. AL732509, AL732578 Genomic DNA. Translation: CAI41676.1. AL732509, AL732578 Genomic DNA. Translation: CAI41677.1. AL732509, AL732578 Genomic DNA. Translation: CAI41678.1.
IPI	IPI00024754. IPI00337662. IPI00409724. IPI00409725. IPI00409726. IPI00409727. IPI00409729. IPI00815637. IPI00871801.
RefSeq	NP_001073327.1. NM_001079858.2. NP_001073328.1. NM_001079859.2. NP_001073329.1. NM_001079860.2. NP_001171762.1. NM_001184833.1. NP_001171763.1. NM_001184834.1. NP_001171764.1. NM_001184835.1. NP_001171765.1. NM_001184836.1. NP_001171766.1. NM_001184837.1. NP_005747.2. NM_005756.3.
UniGene	Hs.146978.
3D structure databases
ProteinModelPortal	Q8IZP9.
ModBase	Search...
Protein family/group databases
MEROPS	S63.010.
GPCRDB	Search...
PTM databases
PhosphoSite	Q8IZP9.
Polymorphism databases
DMDM	229462874.
Proteomic databases
PaxDb	Q8IZP9.
PRIDE	Q8IZP9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356606; ENSP00000349015; ENSG00000173698. ENST00000357544; ENSP00000350152; ENSG00000173698. ENST00000357991; ENSP00000350680; ENSG00000173698. ENST00000360279; ENSP00000353421; ENSG00000173698. ENST00000379869; ENSP00000369198; ENSG00000173698. ENST00000379873; ENSP00000369202; ENSG00000173698. ENST00000379876; ENSP00000369205; ENSG00000173698. ENST00000379878; ENSP00000369207; ENSG00000173698.
GeneID	10149.
KEGG	hsa:10149.
UCSC	uc004cyx.3. human. uc004cyy.3. human. uc004cyz.3. human. uc004cza.3. human. uc004czb.3. human. uc004czc.3. human. uc004czd.3. human. uc004cze.3. human. uc004czf.3. human.
Organism-specific databases
CTD	10149.
GeneCards	GC0XM019007.
H-InvDB	HIX0016685.
HGNC	HGNC:4516. GPR64.
HPA	HPA001478.
MIM	300572. gene.
neXtProt	NX_Q8IZP9.
PharmGKB	PA28908.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOVERGEN	HBG051817.
InParanoid	Q8IZP9.
KO	K08451.
OMA	FIFYCVA.
Gene expression databases
ArrayExpress	Q8IZP9.
Bgee	Q8IZP9.
Genevestigator	Q8IZP9.
GermOnline	ENSG00000173698. Homo sapiens.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR000203. GPS_dom. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN.
SMART	SM00303. GPS. 1 hit. [Graphical view]
PROSITE	PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10149.
NextBio	38407.
SOURCE	Search...

Entry information

Entry name

GPR64_HUMAN

Accession

Primary (citable) accession number: Q8IZP9
Secondary accession number(s): B1AWB3 , B1AWB4, B1AWB6, B1AWB7, O00406, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	May 5, 2009
Last modified:	April 3, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.