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Q8IZP7

- H6ST3_HUMAN

UniProt

Q8IZP7 - H6ST3_HUMAN

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Protein

Heparan-sulfate 6-O-sulfotransferase 3

Gene

HS6ST3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.

GO - Molecular functioni

  1. heparan sulfate 6-O-sulfotransferase activity Source: Ensembl

GO - Biological processi

  1. heparan sulfate proteoglycan biosynthetic process, enzymatic modification Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15787.
ReactomeiREACT_121248. HS-GAG biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferase 3 (EC:2.8.2.-)
Short name:
HS6ST-3
Gene namesi
Name:HS6ST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:19134. HS6ST3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Heparan-sulfate 6-O-sulfotransferase 3PRO_0000190809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZP7.
PRIDEiQ8IZP7.

PTM databases

PhosphoSiteiQ8IZP7.

Expressioni

Gene expression databases

BgeeiQ8IZP7.
CleanExiHS_HS6ST3.
ExpressionAtlasiQ8IZP7. baseline.
GenevestigatoriQ8IZP7.

Organism-specific databases

HPAiHPA051513.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365895.

Structurei

3D structure databases

ProteinModelPortaliQ8IZP7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence Analysis
Topological domaini28 – 471444LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2723Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 16175'-phosphosulfate-bindingSequence Analysis
Regioni245 – 25393'-phosphate bindingSequence Analysis

Sequence similaritiesi

Belongs to the sulfotransferase 6 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302961.
GeneTreeiENSGT00390000013468.
HOGENOMiHOG000007772.
HOVERGENiHBG083012.
InParanoidiQ8IZP7.
KOiK08103.
OMAiDLNFLDM.
OrthoDBiEOG75MVW3.
PhylomeDBiQ8IZP7.
TreeFamiTF312835.

Family and domain databases

InterProiIPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PANTHERiPTHR12812. PTHR12812. 1 hit.
PfamiPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IZP7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDERFNKWLL TPVLTLLFVV IMYQYVSPSC TSSCTNFGEQ PRAGEAGPPA
60 70 80 90 100
VPGPARRAQA PPEEWERRPQ LPPPPRGPPE GPRGAAAPEE EDEEPGDPRE
110 120 130 140 150
GEEEEEEDEP DPEAPENGSL PRFVPRFNFS LKDLTRFVDF NIKGRDVIVF
160 170 180 190 200
LHIQKTGGTT FGRHLVKNIR LEQPCSCKAG QKKCTCHRPG KKETWLFSRF
210 220 230 240 250
STGWSCGLHA DWTELTNCVP AIMEKKDCPR NHSHTRNFYY ITMLRDPVSR
260 270 280 290 300
YLSEWKHVQR GATWKTSLHM CDGRSPTPDE LPTCYPGDDW SGVSLREFMD
310 320 330 340 350
CTYNLANNRQ VRMLADLSLV GCYNLTFMNE SERNTILLQS AKNNLKNMAF
360 370 380 390 400
FGLTEFQRKT QFLFERTFNL KFISPFTQFN ITRASNVEIN EGARQRIEDL
410 420 430 440 450
NFLDMQLYEY AKDLFQQRYH HTKQLEHQRD RQKRREERRL QREHRDHQWP
460 470
KEDGAAEGTV TEDYNSQVVR W
Length:471
Mass (Da):54,844
Last modified:October 17, 2006 - v3
Checksum:i4A5F4DEA26FC7302
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371F → L in AAN33062. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti265 – 2651K → R.
Corresponds to variant rs9516771 [ dbSNP | Ensembl ].
VAR_028159

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF539426 mRNA. Translation: AAN33062.1.
AL138816, AL158192 Genomic DNA. Translation: CAH71574.1.
AL158192, AL138816 Genomic DNA. Translation: CAI13709.1.
CR749677 mRNA. Translation: CAH18468.1.
CCDSiCCDS9481.1.
RefSeqiNP_703157.2. NM_153456.3.
XP_003846618.1. XM_003846570.1.
UniGeneiHs.171001.
Hs.740393.

Genome annotation databases

EnsembliENST00000376705; ENSP00000365895; ENSG00000185352.
GeneIDi266722.
KEGGihsa:266722.
UCSCiuc001vmw.4. human.

Polymorphism databases

DMDMi116242508.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF539426 mRNA. Translation: AAN33062.1 .
AL138816 , AL158192 Genomic DNA. Translation: CAH71574.1 .
AL158192 , AL138816 Genomic DNA. Translation: CAI13709.1 .
CR749677 mRNA. Translation: CAH18468.1 .
CCDSi CCDS9481.1.
RefSeqi NP_703157.2. NM_153456.3.
XP_003846618.1. XM_003846570.1.
UniGenei Hs.171001.
Hs.740393.

3D structure databases

ProteinModelPortali Q8IZP7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000365895.

PTM databases

PhosphoSitei Q8IZP7.

Polymorphism databases

DMDMi 116242508.

Proteomic databases

PaxDbi Q8IZP7.
PRIDEi Q8IZP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376705 ; ENSP00000365895 ; ENSG00000185352 .
GeneIDi 266722.
KEGGi hsa:266722.
UCSCi uc001vmw.4. human.

Organism-specific databases

CTDi 266722.
GeneCardsi GC13P096743.
H-InvDB HIX0011412.
HGNCi HGNC:19134. HS6ST3.
HPAi HPA051513.
MIMi 609401. gene.
neXtProti NX_Q8IZP7.
PharmGKBi PA134879312.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302961.
GeneTreei ENSGT00390000013468.
HOGENOMi HOG000007772.
HOVERGENi HBG083012.
InParanoidi Q8IZP7.
KOi K08103.
OMAi DLNFLDM.
OrthoDBi EOG75MVW3.
PhylomeDBi Q8IZP7.
TreeFami TF312835.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-15787.
Reactomei REACT_121248. HS-GAG biosynthesis.

Miscellaneous databases

ChiTaRSi HS6ST3. human.
GenomeRNAii 266722.
NextBioi 93320.
PROi Q8IZP7.
SOURCEi Search...

Gene expression databases

Bgeei Q8IZP7.
CleanExi HS_HS6ST3.
ExpressionAtlasi Q8IZP7. baseline.
Genevestigatori Q8IZP7.

Family and domain databases

InterProi IPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view ]
PANTHERi PTHR12812. PTHR12812. 1 hit.
Pfami PF03567. Sulfotransfer_2. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The coding sequence of HS6ST3 spans an intron of 741 kb."
    Bonner T.I., Ferraren D.O., Detera-Wadleigh S.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-471.
    Tissue: Amygdala.

Entry informationi

Entry nameiH6ST3_HUMAN
AccessioniPrimary (citable) accession number: Q8IZP7
Secondary accession number(s): Q5W0L0, Q68CW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3