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Q8IZP7

- H6ST3_HUMAN

UniProt

Q8IZP7 - H6ST3_HUMAN

Protein

Heparan-sulfate 6-O-sulfotransferase 3

Gene

HS6ST3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

    Catalytic activityi

    3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.

    GO - Molecular functioni

    1. sulfotransferase activity Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-15787.
    ReactomeiREACT_121248. HS-GAG biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heparan-sulfate 6-O-sulfotransferase 3 (EC:2.8.2.-)
    Short name:
    HS6ST-3
    Gene namesi
    Name:HS6ST3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:19134. HS6ST3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134879312.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Heparan-sulfate 6-O-sulfotransferase 3PRO_0000190809Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8IZP7.
    PRIDEiQ8IZP7.

    PTM databases

    PhosphoSiteiQ8IZP7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IZP7.
    BgeeiQ8IZP7.
    CleanExiHS_HS6ST3.
    GenevestigatoriQ8IZP7.

    Organism-specific databases

    HPAiHPA051513.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000365895.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 44CytoplasmicSequence Analysis
    Topological domaini28 – 471444LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2723Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni155 – 16175'-phosphosulfate-bindingSequence Analysis
    Regioni245 – 25393'-phosphate bindingSequence Analysis

    Sequence similaritiesi

    Belongs to the sulfotransferase 6 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302961.
    HOGENOMiHOG000007772.
    HOVERGENiHBG083012.
    InParanoidiQ8IZP7.
    KOiK08103.
    OMAiDLNFLDM.
    OrthoDBiEOG75MVW3.
    PhylomeDBiQ8IZP7.
    TreeFamiTF312835.

    Family and domain databases

    InterProiIPR010635. Heparan_SO4-6-sulfoTrfase.
    IPR027417. P-loop_NTPase.
    IPR005331. Sulfotransferase.
    [Graphical view]
    PANTHERiPTHR12812. PTHR12812. 1 hit.
    PfamiPF03567. Sulfotransfer_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8IZP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDERFNKWLL TPVLTLLFVV IMYQYVSPSC TSSCTNFGEQ PRAGEAGPPA    50
    VPGPARRAQA PPEEWERRPQ LPPPPRGPPE GPRGAAAPEE EDEEPGDPRE 100
    GEEEEEEDEP DPEAPENGSL PRFVPRFNFS LKDLTRFVDF NIKGRDVIVF 150
    LHIQKTGGTT FGRHLVKNIR LEQPCSCKAG QKKCTCHRPG KKETWLFSRF 200
    STGWSCGLHA DWTELTNCVP AIMEKKDCPR NHSHTRNFYY ITMLRDPVSR 250
    YLSEWKHVQR GATWKTSLHM CDGRSPTPDE LPTCYPGDDW SGVSLREFMD 300
    CTYNLANNRQ VRMLADLSLV GCYNLTFMNE SERNTILLQS AKNNLKNMAF 350
    FGLTEFQRKT QFLFERTFNL KFISPFTQFN ITRASNVEIN EGARQRIEDL 400
    NFLDMQLYEY AKDLFQQRYH HTKQLEHQRD RQKRREERRL QREHRDHQWP 450
    KEDGAAEGTV TEDYNSQVVR W 471
    Length:471
    Mass (Da):54,844
    Last modified:October 17, 2006 - v3
    Checksum:i4A5F4DEA26FC7302
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371F → L in AAN33062. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti265 – 2651K → R.
    Corresponds to variant rs9516771 [ dbSNP | Ensembl ].
    VAR_028159

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF539426 mRNA. Translation: AAN33062.1.
    AL138816, AL158192 Genomic DNA. Translation: CAH71574.1.
    AL158192, AL138816 Genomic DNA. Translation: CAI13709.1.
    CR749677 mRNA. Translation: CAH18468.1.
    CCDSiCCDS9481.1.
    RefSeqiNP_703157.2. NM_153456.3.
    XP_003846618.1. XM_003846570.1.
    UniGeneiHs.171001.
    Hs.740393.

    Genome annotation databases

    EnsembliENST00000376705; ENSP00000365895; ENSG00000185352.
    GeneIDi266722.
    KEGGihsa:266722.
    UCSCiuc001vmw.4. human.

    Polymorphism databases

    DMDMi116242508.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF539426 mRNA. Translation: AAN33062.1 .
    AL138816 , AL158192 Genomic DNA. Translation: CAH71574.1 .
    AL158192 , AL138816 Genomic DNA. Translation: CAI13709.1 .
    CR749677 mRNA. Translation: CAH18468.1 .
    CCDSi CCDS9481.1.
    RefSeqi NP_703157.2. NM_153456.3.
    XP_003846618.1. XM_003846570.1.
    UniGenei Hs.171001.
    Hs.740393.

    3D structure databases

    ProteinModelPortali Q8IZP7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000365895.

    PTM databases

    PhosphoSitei Q8IZP7.

    Polymorphism databases

    DMDMi 116242508.

    Proteomic databases

    PaxDbi Q8IZP7.
    PRIDEi Q8IZP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376705 ; ENSP00000365895 ; ENSG00000185352 .
    GeneIDi 266722.
    KEGGi hsa:266722.
    UCSCi uc001vmw.4. human.

    Organism-specific databases

    CTDi 266722.
    GeneCardsi GC13P096743.
    H-InvDB HIX0011412.
    HGNCi HGNC:19134. HS6ST3.
    HPAi HPA051513.
    MIMi 609401. gene.
    neXtProti NX_Q8IZP7.
    PharmGKBi PA134879312.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302961.
    HOGENOMi HOG000007772.
    HOVERGENi HBG083012.
    InParanoidi Q8IZP7.
    KOi K08103.
    OMAi DLNFLDM.
    OrthoDBi EOG75MVW3.
    PhylomeDBi Q8IZP7.
    TreeFami TF312835.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-15787.
    Reactomei REACT_121248. HS-GAG biosynthesis.

    Miscellaneous databases

    ChiTaRSi HS6ST3. human.
    GenomeRNAii 266722.
    NextBioi 93320.
    PROi Q8IZP7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZP7.
    Bgeei Q8IZP7.
    CleanExi HS_HS6ST3.
    Genevestigatori Q8IZP7.

    Family and domain databases

    InterProi IPR010635. Heparan_SO4-6-sulfoTrfase.
    IPR027417. P-loop_NTPase.
    IPR005331. Sulfotransferase.
    [Graphical view ]
    PANTHERi PTHR12812. PTHR12812. 1 hit.
    Pfami PF03567. Sulfotransfer_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The coding sequence of HS6ST3 spans an intron of 741 kb."
      Bonner T.I., Ferraren D.O., Detera-Wadleigh S.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-471.
      Tissue: Amygdala.

    Entry informationi

    Entry nameiH6ST3_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZP7
    Secondary accession number(s): Q5W0L0, Q68CW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3