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Q8IZP7 (H6ST3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heparan-sulfate 6-O-sulfotransferase 3

Short name=HS6ST-3
EC=2.8.2.-
Gene names
Name:HS6ST3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Catalytic activity

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the sulfotransferase 6 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionTransferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsulfotransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Heparan-sulfate 6-O-sulfotransferase 3
PRO_0000190809

Regions

Topological domain1 – 44Cytoplasmic Potential
Transmembrane5 – 2723Helical; Signal-anchor for type II membrane protein; Potential
Topological domain28 – 471444Lumenal Potential
Region155 – 16175'-phosphosulfate-binding Potential
Region245 – 25393'-phosphate binding Potential

Amino acid modifications

Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation3241N-linked (GlcNAc...) Potential
Glycosylation3291N-linked (GlcNAc...) Potential
Glycosylation3801N-linked (GlcNAc...) Potential

Natural variations

Natural variant2651K → R.
Corresponds to variant rs9516771 [ dbSNP | Ensembl ].
VAR_028159

Experimental info

Sequence conflict371F → L in AAN33062. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8IZP7 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: 4A5F4DEA26FC7302

FASTA47154,844
        10         20         30         40         50         60 
MDERFNKWLL TPVLTLLFVV IMYQYVSPSC TSSCTNFGEQ PRAGEAGPPA VPGPARRAQA 

        70         80         90        100        110        120 
PPEEWERRPQ LPPPPRGPPE GPRGAAAPEE EDEEPGDPRE GEEEEEEDEP DPEAPENGSL 

       130        140        150        160        170        180 
PRFVPRFNFS LKDLTRFVDF NIKGRDVIVF LHIQKTGGTT FGRHLVKNIR LEQPCSCKAG 

       190        200        210        220        230        240 
QKKCTCHRPG KKETWLFSRF STGWSCGLHA DWTELTNCVP AIMEKKDCPR NHSHTRNFYY 

       250        260        270        280        290        300 
ITMLRDPVSR YLSEWKHVQR GATWKTSLHM CDGRSPTPDE LPTCYPGDDW SGVSLREFMD 

       310        320        330        340        350        360 
CTYNLANNRQ VRMLADLSLV GCYNLTFMNE SERNTILLQS AKNNLKNMAF FGLTEFQRKT 

       370        380        390        400        410        420 
QFLFERTFNL KFISPFTQFN ITRASNVEIN EGARQRIEDL NFLDMQLYEY AKDLFQQRYH 

       430        440        450        460        470 
HTKQLEHQRD RQKRREERRL QREHRDHQWP KEDGAAEGTV TEDYNSQVVR W 

« Hide

References

« Hide 'large scale' references
[1]"The coding sequence of HS6ST3 spans an intron of 741 kb."
Bonner T.I., Ferraren D.O., Detera-Wadleigh S.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-471.
Tissue: Amygdala.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF539426 mRNA. Translation: AAN33062.1.
AL138816, AL158192 Genomic DNA. Translation: CAH71574.1.
AL158192, AL138816 Genomic DNA. Translation: CAI13709.1.
CR749677 mRNA. Translation: CAH18468.1.
CCDSCCDS9481.1.
RefSeqNP_703157.2. NM_153456.3.
XP_003846618.1. XM_003846570.1.
UniGeneHs.171001.
Hs.740393.

3D structure databases

ProteinModelPortalQ8IZP7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000365895.

PTM databases

PhosphoSiteQ8IZP7.

Polymorphism databases

DMDM116242508.

Proteomic databases

PaxDbQ8IZP7.
PRIDEQ8IZP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376705; ENSP00000365895; ENSG00000185352.
GeneID266722.
KEGGhsa:266722.
UCSCuc001vmw.4. human.

Organism-specific databases

CTD266722.
GeneCardsGC13P096743.
H-InvDBHIX0011412.
HGNCHGNC:19134. HS6ST3.
HPAHPA051513.
MIM609401. gene.
neXtProtNX_Q8IZP7.
PharmGKBPA134879312.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302961.
HOGENOMHOG000007772.
HOVERGENHBG083012.
InParanoidQ8IZP7.
KOK08103.
OMADLNFLDM.
OrthoDBEOG75MVW3.
PhylomeDBQ8IZP7.
TreeFamTF312835.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-15787.
ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.

Gene expression databases

ArrayExpressQ8IZP7.
BgeeQ8IZP7.
CleanExHS_HS6ST3.
GenevestigatorQ8IZP7.

Family and domain databases

InterProIPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PANTHERPTHR12812. PTHR12812. 1 hit.
PfamPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

ChiTaRSHS6ST3. human.
GenomeRNAi266722.
NextBio93320.
PROQ8IZP7.
SOURCESearch...

Entry information

Entry nameH6ST3_HUMAN
AccessionPrimary (citable) accession number: Q8IZP7
Secondary accession number(s): Q5W0L0, Q68CW6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM