Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heparan-sulfate 6-O-sulfotransferase 3

Gene

HS6ST3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15787.
ReactomeiREACT_121248. HS-GAG biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferase 3 (EC:2.8.2.-)
Short name:
HS6ST-3
Gene namesi
Name:HS6ST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:19134. HS6ST3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44CytoplasmicSequence Analysis
Transmembranei5 – 2723Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini28 – 471444LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879312.

Polymorphism and mutation databases

BioMutaiHS6ST3.
DMDMi116242508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Heparan-sulfate 6-O-sulfotransferase 3PRO_0000190809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZP7.
PRIDEiQ8IZP7.

PTM databases

PhosphoSiteiQ8IZP7.

Expressioni

Gene expression databases

BgeeiQ8IZP7.
CleanExiHS_HS6ST3.
ExpressionAtlasiQ8IZP7. baseline and differential.
GenevisibleiQ8IZP7. HS.

Organism-specific databases

HPAiHPA051513.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365895.

Structurei

3D structure databases

ProteinModelPortaliQ8IZP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 16175'-phosphosulfate-bindingSequence Analysis
Regioni245 – 25393'-phosphate bindingSequence Analysis

Sequence similaritiesi

Belongs to the sulfotransferase 6 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302961.
GeneTreeiENSGT00390000013468.
HOGENOMiHOG000007772.
HOVERGENiHBG083012.
InParanoidiQ8IZP7.
KOiK08103.
OMAiDLNFLDM.
OrthoDBiEOG75MVW3.
PhylomeDBiQ8IZP7.
TreeFamiTF312835.

Family and domain databases

InterProiIPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PANTHERiPTHR12812. PTHR12812. 1 hit.
PfamiPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IZP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDERFNKWLL TPVLTLLFVV IMYQYVSPSC TSSCTNFGEQ PRAGEAGPPA
60 70 80 90 100
VPGPARRAQA PPEEWERRPQ LPPPPRGPPE GPRGAAAPEE EDEEPGDPRE
110 120 130 140 150
GEEEEEEDEP DPEAPENGSL PRFVPRFNFS LKDLTRFVDF NIKGRDVIVF
160 170 180 190 200
LHIQKTGGTT FGRHLVKNIR LEQPCSCKAG QKKCTCHRPG KKETWLFSRF
210 220 230 240 250
STGWSCGLHA DWTELTNCVP AIMEKKDCPR NHSHTRNFYY ITMLRDPVSR
260 270 280 290 300
YLSEWKHVQR GATWKTSLHM CDGRSPTPDE LPTCYPGDDW SGVSLREFMD
310 320 330 340 350
CTYNLANNRQ VRMLADLSLV GCYNLTFMNE SERNTILLQS AKNNLKNMAF
360 370 380 390 400
FGLTEFQRKT QFLFERTFNL KFISPFTQFN ITRASNVEIN EGARQRIEDL
410 420 430 440 450
NFLDMQLYEY AKDLFQQRYH HTKQLEHQRD RQKRREERRL QREHRDHQWP
460 470
KEDGAAEGTV TEDYNSQVVR W
Length:471
Mass (Da):54,844
Last modified:October 17, 2006 - v3
Checksum:i4A5F4DEA26FC7302
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371F → L in AAN33062 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti265 – 2651K → R.
Corresponds to variant rs9516771 [ dbSNP | Ensembl ].
VAR_028159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539426 mRNA. Translation: AAN33062.1.
AL138816, AL158192 Genomic DNA. Translation: CAH71574.1.
AL158192, AL138816 Genomic DNA. Translation: CAI13709.1.
CR749677 mRNA. Translation: CAH18468.1.
CCDSiCCDS9481.1.
RefSeqiNP_703157.2. NM_153456.3.
UniGeneiHs.171001.
Hs.740393.

Genome annotation databases

EnsembliENST00000376705; ENSP00000365895; ENSG00000185352.
GeneIDi266722.
KEGGihsa:266722.
UCSCiuc001vmw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539426 mRNA. Translation: AAN33062.1.
AL138816, AL158192 Genomic DNA. Translation: CAH71574.1.
AL158192, AL138816 Genomic DNA. Translation: CAI13709.1.
CR749677 mRNA. Translation: CAH18468.1.
CCDSiCCDS9481.1.
RefSeqiNP_703157.2. NM_153456.3.
UniGeneiHs.171001.
Hs.740393.

3D structure databases

ProteinModelPortaliQ8IZP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365895.

PTM databases

PhosphoSiteiQ8IZP7.

Polymorphism and mutation databases

BioMutaiHS6ST3.
DMDMi116242508.

Proteomic databases

PaxDbiQ8IZP7.
PRIDEiQ8IZP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376705; ENSP00000365895; ENSG00000185352.
GeneIDi266722.
KEGGihsa:266722.
UCSCiuc001vmw.4. human.

Organism-specific databases

CTDi266722.
GeneCardsiGC13P096743.
H-InvDBHIX0011412.
HGNCiHGNC:19134. HS6ST3.
HPAiHPA051513.
MIMi609401. gene.
neXtProtiNX_Q8IZP7.
PharmGKBiPA134879312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG302961.
GeneTreeiENSGT00390000013468.
HOGENOMiHOG000007772.
HOVERGENiHBG083012.
InParanoidiQ8IZP7.
KOiK08103.
OMAiDLNFLDM.
OrthoDBiEOG75MVW3.
PhylomeDBiQ8IZP7.
TreeFamiTF312835.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15787.
ReactomeiREACT_121248. HS-GAG biosynthesis.

Miscellaneous databases

ChiTaRSiHS6ST3. human.
GenomeRNAii266722.
NextBioi93320.
PROiQ8IZP7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZP7.
CleanExiHS_HS6ST3.
ExpressionAtlasiQ8IZP7. baseline and differential.
GenevisibleiQ8IZP7. HS.

Family and domain databases

InterProiIPR010635. Heparan_SO4-6-sulfoTrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PANTHERiPTHR12812. PTHR12812. 1 hit.
PfamiPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The coding sequence of HS6ST3 spans an intron of 741 kb."
    Bonner T.I., Ferraren D.O., Detera-Wadleigh S.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-471.
    Tissue: Amygdala.

Entry informationi

Entry nameiH6ST3_HUMAN
AccessioniPrimary (citable) accession number: Q8IZP7
Secondary accession number(s): Q5W0L0, Q68CW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.