ID   R113B_HUMAN             Reviewed;         322 AA.
AC   Q8IZP6; Q8WWF9; Q96QY9;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 3.
DT   24-JAN-2024, entry version 160.
DE   RecName: Full=RING finger protein 113B;
DE   AltName: Full=Zinc finger protein 183-like 1;
GN   Name=RNF113B; Synonyms=RNF161, ZNF183L1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Bonner T.I., Ferraren D.O., Detera-Wadleigh S.;
RT   "A testis cDNA for a zinc finger gene closely related to ZNF183.";
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   STRUCTURE BY NMR OF 246-313.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of the RING domain of the zinc finger protein 183-like
RT   1.";
RL   Submitted (NOV-2005) to the PDB data bank.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF539427; AAN33063.1; -; mRNA.
DR   EMBL; AL136300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC017585; AAH17585.1; -; mRNA.
DR   EMBL; BC025388; AAH25388.1; -; mRNA.
DR   CCDS; CCDS9486.1; -.
DR   RefSeq; NP_849192.1; NM_178861.4.
DR   PDB; 2CSY; NMR; -; A=246-313.
DR   PDBsum; 2CSY; -.
DR   AlphaFoldDB; Q8IZP6; -.
DR   SMR; Q8IZP6; -.
DR   BioGRID; 126603; 8.
DR   IntAct; Q8IZP6; 4.
DR   STRING; 9606.ENSP00000267291; -.
DR   iPTMnet; Q8IZP6; -.
DR   PhosphoSitePlus; Q8IZP6; -.
DR   BioMuta; RNF113B; -.
DR   DMDM; 51338806; -.
DR   jPOST; Q8IZP6; -.
DR   MassIVE; Q8IZP6; -.
DR   MaxQB; Q8IZP6; -.
DR   PaxDb; 9606-ENSP00000267291; -.
DR   PeptideAtlas; Q8IZP6; -.
DR   ProteomicsDB; 71393; -.
DR   Antibodypedia; 10782; 276 antibodies from 24 providers.
DR   DNASU; 140432; -.
DR   Ensembl; ENST00000267291.7; ENSP00000267291.6; ENSG00000139797.8.
DR   GeneID; 140432; -.
DR   KEGG; hsa:140432; -.
DR   MANE-Select; ENST00000267291.7; ENSP00000267291.6; NM_178861.5; NP_849192.1.
DR   UCSC; uc001vnk.4; human.
DR   AGR; HGNC:17267; -.
DR   CTD; 140432; -.
DR   GeneCards; RNF113B; -.
DR   HGNC; HGNC:17267; RNF113B.
DR   HPA; ENSG00000139797; Tissue enriched (testis).
DR   neXtProt; NX_Q8IZP6; -.
DR   OpenTargets; ENSG00000139797; -.
DR   PharmGKB; PA38217; -.
DR   VEuPathDB; HostDB:ENSG00000139797; -.
DR   eggNOG; KOG1813; Eukaryota.
DR   GeneTree; ENSGT00390000016292; -.
DR   HOGENOM; CLU_050460_1_0_1; -.
DR   InParanoid; Q8IZP6; -.
DR   OMA; GICEDEN; -.
DR   OrthoDB; 21858at2759; -.
DR   PhylomeDB; Q8IZP6; -.
DR   TreeFam; TF313469; -.
DR   PathwayCommons; Q8IZP6; -.
DR   SignaLink; Q8IZP6; -.
DR   SIGNOR; Q8IZP6; -.
DR   BioGRID-ORCS; 140432; 5 hits in 1177 CRISPR screens.
DR   EvolutionaryTrace; Q8IZP6; -.
DR   GenomeRNAi; 140432; -.
DR   Pharos; Q8IZP6; Tdark.
DR   PRO; PR:Q8IZP6; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; Q8IZP6; Protein.
DR   Bgee; ENSG00000139797; Expressed in left testis and 26 other cell types or tissues.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0034247; P:snoRNA splicing; IBA:GO_Central.
DR   CDD; cd16539; RING-HC_RNF113A_B; 1.
DR   Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR039971; CWC24-like.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR12930:SF1; RING FINGER PROTEIN 113B; 1.
DR   PANTHER; PTHR12930; ZINC FINGER PROTEIN 183; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF90229; CCCH zinc finger; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..322
FT                   /note="RING finger protein 113B"
FT                   /id="PRO_0000056088"
FT   ZN_FING         190..218
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         256..294
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          24..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..88
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         92
FT                   /note="V -> M (in dbSNP:rs16955011)"
FT                   /id="VAR_052104"
FT   CONFLICT        56
FT                   /note="V -> A (in Ref. 1; AAN33063)"
FT                   /evidence="ECO:0000305"
FT   STRAND          257..259
FT                   /evidence="ECO:0007829|PDB:2CSY"
FT   STRAND          265..268
FT                   /evidence="ECO:0007829|PDB:2CSY"
FT   STRAND          274..276
FT                   /evidence="ECO:0007829|PDB:2CSY"
FT   HELIX           277..286
FT                   /evidence="ECO:0007829|PDB:2CSY"
FT   STRAND          291..293
FT                   /evidence="ECO:0007829|PDB:2CSY"
FT   HELIX           305..311
FT                   /evidence="ECO:0007829|PDB:2CSY"
SQ   SEQUENCE   322 AA;  36259 MW;  9D2E63F623150578 CRC64;
     MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG DEGDTVAQPP
     RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA KPVGPEDMGA TADFEQDTEK
     EHHTPTILKC SQRVQEALRG REHDHIYRGI HSYLRYLKPK DTSMGNSSSG MARKGPIRAP
     GHLRATVRWD YQPDICKDYK ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED
     ENHEVGSEEE EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI
     FNPAKELMAK LQKLQAAEGK KR
//