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Protein

RING finger protein 113B

Gene

RNF113B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 218C3H1-typePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri256 – 294RING-typePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 113B
Alternative name(s):
Zinc finger protein 183-like 1
Gene namesi
Name:RNF113B
Synonyms:RNF161, ZNF183L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:17267. RNF113B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139797.
PharmGKBiPA38217.

Polymorphism and mutation databases

BioMutaiRNF113B.
DMDMi51338806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560881 – 322RING finger protein 113BAdd BLAST322

Proteomic databases

MaxQBiQ8IZP6.
PaxDbiQ8IZP6.
PeptideAtlasiQ8IZP6.
PRIDEiQ8IZP6.

Expressioni

Gene expression databases

BgeeiENSG00000139797.
CleanExiHS_RNF113B.

Organism-specific databases

HPAiHPA023339.

Interactioni

Protein-protein interaction databases

BioGridi126603. 5 interactors.
IntActiQ8IZP6. 3 interactors.
STRINGi9606.ENSP00000267291.

Structurei

Secondary structure

1322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi257 – 259Combined sources3
Beta strandi265 – 268Combined sources4
Beta strandi274 – 276Combined sources3
Helixi277 – 286Combined sources10
Beta strandi291 – 293Combined sources3
Helixi305 – 311Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSYNMR-A246-313[»]
ProteinModelPortaliQ8IZP6.
SMRiQ8IZP6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IZP6.

Family & Domainsi

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 218C3H1-typePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri256 – 294RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1813. Eukaryota.
COG5152. LUCA.
GeneTreeiENSGT00390000016292.
HOGENOMiHOG000174759.
HOVERGENiHBG060697.
InParanoidiQ8IZP6.
KOiK15696.
OMAiFRATPRC.
OrthoDBiEOG091G0FAM.
PhylomeDBiQ8IZP6.
TreeFamiTF313469.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG
60 70 80 90 100
DEGDTVAQPP RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA
110 120 130 140 150
KPVGPEDMGA TADFEQDTEK EHHTPTILKC SQRVQEALRG REHDHIYRGI
160 170 180 190 200
HSYLRYLKPK DTSMGNSSSG MARKGPIRAP GHLRATVRWD YQPDICKDYK
210 220 230 240 250
ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED ENHEVGSEEE
260 270 280 290 300
EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI
310 320
FNPAKELMAK LQKLQAAEGK KR
Length:322
Mass (Da):36,259
Last modified:August 16, 2004 - v3
Checksum:i9D2E63F623150578
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56V → A in AAN33063 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05210492V → M.Corresponds to variant rs16955011dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539427 mRNA. Translation: AAN33063.1.
AL136300 Genomic DNA. Translation: CAC42525.2.
BC017585 mRNA. Translation: AAH17585.1.
BC025388 mRNA. Translation: AAH25388.1.
CCDSiCCDS9486.1.
RefSeqiNP_849192.1. NM_178861.4.
UniGeneiHs.296045.

Genome annotation databases

EnsembliENST00000267291; ENSP00000267291; ENSG00000139797.
GeneIDi140432.
KEGGihsa:140432.
UCSCiuc001vnk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539427 mRNA. Translation: AAN33063.1.
AL136300 Genomic DNA. Translation: CAC42525.2.
BC017585 mRNA. Translation: AAH17585.1.
BC025388 mRNA. Translation: AAH25388.1.
CCDSiCCDS9486.1.
RefSeqiNP_849192.1. NM_178861.4.
UniGeneiHs.296045.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSYNMR-A246-313[»]
ProteinModelPortaliQ8IZP6.
SMRiQ8IZP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126603. 5 interactors.
IntActiQ8IZP6. 3 interactors.
STRINGi9606.ENSP00000267291.

Polymorphism and mutation databases

BioMutaiRNF113B.
DMDMi51338806.

Proteomic databases

MaxQBiQ8IZP6.
PaxDbiQ8IZP6.
PeptideAtlasiQ8IZP6.
PRIDEiQ8IZP6.

Protocols and materials databases

DNASUi140432.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267291; ENSP00000267291; ENSG00000139797.
GeneIDi140432.
KEGGihsa:140432.
UCSCiuc001vnk.4. human.

Organism-specific databases

CTDi140432.
GeneCardsiRNF113B.
HGNCiHGNC:17267. RNF113B.
HPAiHPA023339.
neXtProtiNX_Q8IZP6.
OpenTargetsiENSG00000139797.
PharmGKBiPA38217.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1813. Eukaryota.
COG5152. LUCA.
GeneTreeiENSGT00390000016292.
HOGENOMiHOG000174759.
HOVERGENiHBG060697.
InParanoidiQ8IZP6.
KOiK15696.
OMAiFRATPRC.
OrthoDBiEOG091G0FAM.
PhylomeDBiQ8IZP6.
TreeFamiTF313469.

Miscellaneous databases

EvolutionaryTraceiQ8IZP6.
GenomeRNAii140432.
PROiQ8IZP6.

Gene expression databases

BgeeiENSG00000139797.
CleanExiHS_RNF113B.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiR113B_HUMAN
AccessioniPrimary (citable) accession number: Q8IZP6
Secondary accession number(s): Q8WWF9, Q96QY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.