Q8IZP6 (R113B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RING finger protein 113B

Alternative name(s):
Zinc finger protein 183-like 1

Gene names

Name:	RNF113B
Synonyms:	RNF161, ZNF183L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 C3H1-type zinc finger. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 322

322

RING finger protein 113B

PRO_0000056088

Regions

Zinc finger

190 – 218

29

C3H1-type

Zinc finger

256 – 294

39

RING-type

Natural variations

Natural variant

92

1

V → M.
Corresponds to variant rs16955011 [ dbSNP | Ensembl ].

VAR_052104

Experimental info

Sequence conflict

56

1

V → A in AAN33063. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

322

Helix Strand Turn

Details...

Beta strand

257 – 259

3

Beta strand

265 – 268

4

Beta strand

274 – 276

3

Helix

277 – 286

10

Beta strand

291 – 293

3

Helix

305 – 311

7

Sequences

	Sequence		Length	Mass (Da)
	Q8IZP6 [UniParc]. Last modified August 16, 2004. Version 3. Checksum: 9D2E63F623150578	FASTA	322	36,259
	10 20 30 40 50 60 MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG DEGDTVAQPP 70 80 90 100 110 120 RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA KPVGPEDMGA TADFEQDTEK 130 140 150 160 170 180 EHHTPTILKC SQRVQEALRG REHDHIYRGI HSYLRYLKPK DTSMGNSSSG MARKGPIRAP 190 200 210 220 230 240 GHLRATVRWD YQPDICKDYK ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED 250 260 270 280 290 300 ENHEVGSEEE EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI 310 320 FNPAKELMAK LQKLQAAEGK KR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A testis cDNA for a zinc finger gene closely related to ZNF183." Bonner T.I., Ferraren D.O., Detera-Wadleigh S. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Solution structure of the RING domain of the zinc finger protein 183-like 1." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 246-313.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF539427 mRNA. Translation: AAN33063.1.
AL136300 Genomic DNA. Translation: CAC42525.2.
BC017585 mRNA. Translation: AAH17585.1.
BC025388 mRNA. Translation: AAH25388.1.

IPI

IPI00647897.

RefSeq

NP_849192.1. NM_178861.4.

UniGene

Hs.296045.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CSY	NMR	-	A	246-313	[»]

ProteinModelPortal

Q8IZP6.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8IZP6. 3 interactions.

STRING

9606.ENSP00000267291.

Polymorphism databases

DMDM

51338806.

Proteomic databases

PaxDb

Q8IZP6.

PRIDE

Q8IZP6.

Protocols and materials databases

DNASU

140432.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000267291; ENSP00000267291; ENSG00000139797.

GeneID

140432.

KEGG

hsa:140432.

UCSC

uc001vnk.3. human.

Organism-specific databases

CTD

140432.

GeneCards

GC13M098828.

HGNC

HGNC:17267. RNF113B.

HPA

HPA023339.

neXtProt

NX_Q8IZP6.

PharmGKB

PA38217.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5152.

HOGENOM

HOG000174759.

HOVERGEN

HBG060697.

InParanoid

Q8IZP6.

KO

K15696.

OMA

FRATPRC.

OrthoDB

EOG4WWRJX.

PhylomeDB

Q8IZP6.

Gene expression databases

Bgee

Q8IZP6.

CleanEx

HS_RNF113B.

Genevestigator

Q8IZP6.

Family and domain databases

Gene3D

3.30.40.10. 1 hit.

InterPro

IPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]

Pfam

PF00642. zf-CCCH. 1 hit.
[Graphical view]

SMART

SM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]

PROSITE

PS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8IZP6.

GenomeRNAi

140432.

NextBio

84083.

Entry information

Entry name

R113B_HUMAN

Accession

Primary (citable) accession number: Q8IZP6
Secondary accession number(s): Q8WWF9, Q96QY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.