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Q8IZP6 (R113B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RING finger protein 113B
Alternative name(s):
Zinc finger protein 183-like 1
Gene names
Name:RNF113B
Synonyms:RNF161, ZNF183L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 C3H1-type zinc finger.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322RING finger protein 113B
PRO_0000056088

Regions

Zinc finger190 – 21829C3H1-type
Zinc finger256 – 29439RING-type

Natural variations

Natural variant921V → M.
Corresponds to variant rs16955011 [ dbSNP | Ensembl ].
VAR_052104

Experimental info

Sequence conflict561V → A in AAN33063. Ref.1

Secondary structure

............ 322
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8IZP6 [UniParc].

Last modified August 16, 2004. Version 3.
Checksum: 9D2E63F623150578

FASTA32236,259
        10         20         30         40         50         60 
MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG DEGDTVAQPP 

        70         80         90        100        110        120 
RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA KPVGPEDMGA TADFEQDTEK 

       130        140        150        160        170        180 
EHHTPTILKC SQRVQEALRG REHDHIYRGI HSYLRYLKPK DTSMGNSSSG MARKGPIRAP 

       190        200        210        220        230        240 
GHLRATVRWD YQPDICKDYK ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED 

       250        260        270        280        290        300 
ENHEVGSEEE EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI 

       310        320 
FNPAKELMAK LQKLQAAEGK KR 

« Hide

References

« Hide 'large scale' references
[1]"A testis cDNA for a zinc finger gene closely related to ZNF183."
Bonner T.I., Ferraren D.O., Detera-Wadleigh S.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Solution structure of the RING domain of the zinc finger protein 183-like 1."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 246-313.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF539427 mRNA. Translation: AAN33063.1.
AL136300 Genomic DNA. Translation: CAC42525.2.
BC017585 mRNA. Translation: AAH17585.1.
BC025388 mRNA. Translation: AAH25388.1.
RefSeqNP_849192.1. NM_178861.4.
UniGeneHs.296045.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSYNMR-A246-313[»]
ProteinModelPortalQ8IZP6.
SMRQ8IZP6. Positions 190-218, 224-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126603. 4 interactions.
IntActQ8IZP6. 3 interactions.
STRING9606.ENSP00000267291.

Polymorphism databases

DMDM51338806.

Proteomic databases

PaxDbQ8IZP6.
PRIDEQ8IZP6.

Protocols and materials databases

DNASU140432.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267291; ENSP00000267291; ENSG00000139797.
GeneID140432.
KEGGhsa:140432.
UCSCuc001vnk.3. human.

Organism-specific databases

CTD140432.
GeneCardsGC13M098828.
HGNCHGNC:17267. RNF113B.
HPAHPA023339.
neXtProtNX_Q8IZP6.
PharmGKBPA38217.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5152.
HOGENOMHOG000174759.
HOVERGENHBG060697.
InParanoidQ8IZP6.
KOK15696.
OMAFRATPRC.
OrthoDBEOG7MSMPM.
PhylomeDBQ8IZP6.
TreeFamTF313469.

Gene expression databases

BgeeQ8IZP6.
CleanExHS_RNF113B.
GenevestigatorQ8IZP6.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProIPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
PROSITEPS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8IZP6.
GenomeRNAi140432.
NextBio84083.
PROQ8IZP6.

Entry information

Entry nameR113B_HUMAN
AccessionPrimary (citable) accession number: Q8IZP6
Secondary accession number(s): Q8WWF9, Q96QY9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 16, 2004
Last modified: March 19, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM