Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8IZP6

- R113B_HUMAN

UniProt

Q8IZP6 - R113B_HUMAN

Protein

RING finger protein 113B

Gene

RNF113B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (16 Aug 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri190 – 21829C3H1-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 29439RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 113B
    Alternative name(s):
    Zinc finger protein 183-like 1
    Gene namesi
    Name:RNF113B
    Synonyms:RNF161, ZNF183L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:17267. RNF113B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38217.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322RING finger protein 113BPRO_0000056088Add
    BLAST

    Proteomic databases

    MaxQBiQ8IZP6.
    PaxDbiQ8IZP6.
    PRIDEiQ8IZP6.

    Expressioni

    Gene expression databases

    BgeeiQ8IZP6.
    CleanExiHS_RNF113B.
    GenevestigatoriQ8IZP6.

    Organism-specific databases

    HPAiHPA023339.

    Interactioni

    Protein-protein interaction databases

    BioGridi126603. 4 interactions.
    IntActiQ8IZP6. 3 interactions.
    STRINGi9606.ENSP00000267291.

    Structurei

    Secondary structure

    1
    322
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi257 – 2593
    Beta strandi265 – 2684
    Beta strandi274 – 2763
    Helixi277 – 28610
    Beta strandi291 – 2933
    Helixi305 – 3117

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CSYNMR-A246-313[»]
    ProteinModelPortaliQ8IZP6.
    SMRiQ8IZP6. Positions 252-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8IZP6.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri190 – 21829C3H1-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 29439RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5152.
    HOGENOMiHOG000174759.
    HOVERGENiHBG060697.
    InParanoidiQ8IZP6.
    KOiK15696.
    OMAiFRATPRC.
    OrthoDBiEOG7MSMPM.
    PhylomeDBiQ8IZP6.
    TreeFamiTF313469.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.1000.10. 1 hit.
    InterProiIPR000571. Znf_CCCH.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00642. zf-CCCH. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00356. ZnF_C3H1. 1 hit.
    [Graphical view]
    PROSITEiPS50103. ZF_C3H1. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IZP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG    50
    DEGDTVAQPP RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA 100
    KPVGPEDMGA TADFEQDTEK EHHTPTILKC SQRVQEALRG REHDHIYRGI 150
    HSYLRYLKPK DTSMGNSSSG MARKGPIRAP GHLRATVRWD YQPDICKDYK 200
    ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED ENHEVGSEEE 250
    EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI 300
    FNPAKELMAK LQKLQAAEGK KR 322
    Length:322
    Mass (Da):36,259
    Last modified:August 16, 2004 - v3
    Checksum:i9D2E63F623150578
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561V → A in AAN33063. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921V → M.
    Corresponds to variant rs16955011 [ dbSNP | Ensembl ].
    VAR_052104

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF539427 mRNA. Translation: AAN33063.1.
    AL136300 Genomic DNA. Translation: CAC42525.2.
    BC017585 mRNA. Translation: AAH17585.1.
    BC025388 mRNA. Translation: AAH25388.1.
    CCDSiCCDS9486.1.
    RefSeqiNP_849192.1. NM_178861.4.
    UniGeneiHs.296045.

    Genome annotation databases

    EnsembliENST00000267291; ENSP00000267291; ENSG00000139797.
    GeneIDi140432.
    KEGGihsa:140432.
    UCSCiuc001vnk.3. human.

    Polymorphism databases

    DMDMi51338806.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF539427 mRNA. Translation: AAN33063.1 .
    AL136300 Genomic DNA. Translation: CAC42525.2 .
    BC017585 mRNA. Translation: AAH17585.1 .
    BC025388 mRNA. Translation: AAH25388.1 .
    CCDSi CCDS9486.1.
    RefSeqi NP_849192.1. NM_178861.4.
    UniGenei Hs.296045.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CSY NMR - A 246-313 [» ]
    ProteinModelPortali Q8IZP6.
    SMRi Q8IZP6. Positions 252-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126603. 4 interactions.
    IntActi Q8IZP6. 3 interactions.
    STRINGi 9606.ENSP00000267291.

    Polymorphism databases

    DMDMi 51338806.

    Proteomic databases

    MaxQBi Q8IZP6.
    PaxDbi Q8IZP6.
    PRIDEi Q8IZP6.

    Protocols and materials databases

    DNASUi 140432.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267291 ; ENSP00000267291 ; ENSG00000139797 .
    GeneIDi 140432.
    KEGGi hsa:140432.
    UCSCi uc001vnk.3. human.

    Organism-specific databases

    CTDi 140432.
    GeneCardsi GC13M098828.
    HGNCi HGNC:17267. RNF113B.
    HPAi HPA023339.
    neXtProti NX_Q8IZP6.
    PharmGKBi PA38217.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5152.
    HOGENOMi HOG000174759.
    HOVERGENi HBG060697.
    InParanoidi Q8IZP6.
    KOi K15696.
    OMAi FRATPRC.
    OrthoDBi EOG7MSMPM.
    PhylomeDBi Q8IZP6.
    TreeFami TF313469.

    Miscellaneous databases

    EvolutionaryTracei Q8IZP6.
    GenomeRNAii 140432.
    NextBioi 84083.
    PROi Q8IZP6.

    Gene expression databases

    Bgeei Q8IZP6.
    CleanExi HS_RNF113B.
    Genevestigatori Q8IZP6.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.1000.10. 1 hit.
    InterProi IPR000571. Znf_CCCH.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00642. zf-CCCH. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00356. ZnF_C3H1. 1 hit.
    [Graphical view ]
    PROSITEi PS50103. ZF_C3H1. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A testis cDNA for a zinc finger gene closely related to ZNF183."
      Bonner T.I., Ferraren D.O., Detera-Wadleigh S.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Solution structure of the RING domain of the zinc finger protein 183-like 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 246-313.

    Entry informationi

    Entry nameiR113B_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZP6
    Secondary accession number(s): Q8WWF9, Q96QY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3