Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IZP6

- R113B_HUMAN

UniProt

Q8IZP6 - R113B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

RING finger protein 113B

Gene

RNF113B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri190 – 21829C3H1-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 29439RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 113B
Alternative name(s):
Zinc finger protein 183-like 1
Gene namesi
Name:RNF113B
Synonyms:RNF161, ZNF183L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:17267. RNF113B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322RING finger protein 113BPRO_0000056088Add
BLAST

Proteomic databases

MaxQBiQ8IZP6.
PaxDbiQ8IZP6.
PRIDEiQ8IZP6.

Expressioni

Gene expression databases

BgeeiQ8IZP6.
CleanExiHS_RNF113B.
GenevestigatoriQ8IZP6.

Organism-specific databases

HPAiHPA023339.

Interactioni

Protein-protein interaction databases

BioGridi126603. 4 interactions.
IntActiQ8IZP6. 3 interactions.
STRINGi9606.ENSP00000267291.

Structurei

Secondary structure

1
322
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi257 – 2593Combined sources
Beta strandi265 – 2684Combined sources
Beta strandi274 – 2763Combined sources
Helixi277 – 28610Combined sources
Beta strandi291 – 2933Combined sources
Helixi305 – 3117Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSYNMR-A246-313[»]
ProteinModelPortaliQ8IZP6.
SMRiQ8IZP6. Positions 252-319.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IZP6.

Family & Domainsi

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri190 – 21829C3H1-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 29439RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5152.
GeneTreeiENSGT00390000016292.
HOGENOMiHOG000174759.
HOVERGENiHBG060697.
InParanoidiQ8IZP6.
KOiK15696.
OMAiFRATPRC.
OrthoDBiEOG7MSMPM.
PhylomeDBiQ8IZP6.
TreeFamiTF313469.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG
60 70 80 90 100
DEGDTVAQPP RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA
110 120 130 140 150
KPVGPEDMGA TADFEQDTEK EHHTPTILKC SQRVQEALRG REHDHIYRGI
160 170 180 190 200
HSYLRYLKPK DTSMGNSSSG MARKGPIRAP GHLRATVRWD YQPDICKDYK
210 220 230 240 250
ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED ENHEVGSEEE
260 270 280 290 300
EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI
310 320
FNPAKELMAK LQKLQAAEGK KR
Length:322
Mass (Da):36,259
Last modified:August 16, 2004 - v3
Checksum:i9D2E63F623150578
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561V → A in AAN33063. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921V → M.
Corresponds to variant rs16955011 [ dbSNP | Ensembl ].
VAR_052104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539427 mRNA. Translation: AAN33063.1.
AL136300 Genomic DNA. Translation: CAC42525.2.
BC017585 mRNA. Translation: AAH17585.1.
BC025388 mRNA. Translation: AAH25388.1.
CCDSiCCDS9486.1.
RefSeqiNP_849192.1. NM_178861.4.
UniGeneiHs.296045.

Genome annotation databases

EnsembliENST00000267291; ENSP00000267291; ENSG00000139797.
GeneIDi140432.
KEGGihsa:140432.
UCSCiuc001vnk.3. human.

Polymorphism databases

DMDMi51338806.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539427 mRNA. Translation: AAN33063.1 .
AL136300 Genomic DNA. Translation: CAC42525.2 .
BC017585 mRNA. Translation: AAH17585.1 .
BC025388 mRNA. Translation: AAH25388.1 .
CCDSi CCDS9486.1.
RefSeqi NP_849192.1. NM_178861.4.
UniGenei Hs.296045.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CSY NMR - A 246-313 [» ]
ProteinModelPortali Q8IZP6.
SMRi Q8IZP6. Positions 252-319.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126603. 4 interactions.
IntActi Q8IZP6. 3 interactions.
STRINGi 9606.ENSP00000267291.

Polymorphism databases

DMDMi 51338806.

Proteomic databases

MaxQBi Q8IZP6.
PaxDbi Q8IZP6.
PRIDEi Q8IZP6.

Protocols and materials databases

DNASUi 140432.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267291 ; ENSP00000267291 ; ENSG00000139797 .
GeneIDi 140432.
KEGGi hsa:140432.
UCSCi uc001vnk.3. human.

Organism-specific databases

CTDi 140432.
GeneCardsi GC13M098828.
HGNCi HGNC:17267. RNF113B.
HPAi HPA023339.
neXtProti NX_Q8IZP6.
PharmGKBi PA38217.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5152.
GeneTreei ENSGT00390000016292.
HOGENOMi HOG000174759.
HOVERGENi HBG060697.
InParanoidi Q8IZP6.
KOi K15696.
OMAi FRATPRC.
OrthoDBi EOG7MSMPM.
PhylomeDBi Q8IZP6.
TreeFami TF313469.

Miscellaneous databases

EvolutionaryTracei Q8IZP6.
GenomeRNAii 140432.
NextBioi 84083.
PROi Q8IZP6.

Gene expression databases

Bgeei Q8IZP6.
CleanExi HS_RNF113B.
Genevestigatori Q8IZP6.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProi IPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00642. zf-CCCH. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view ]
PROSITEi PS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A testis cDNA for a zinc finger gene closely related to ZNF183."
    Bonner T.I., Ferraren D.O., Detera-Wadleigh S.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Solution structure of the RING domain of the zinc finger protein 183-like 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 246-313.

Entry informationi

Entry nameiR113B_HUMAN
AccessioniPrimary (citable) accession number: Q8IZP6
Secondary accession number(s): Q8WWF9, Q96QY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3