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Protein

RING finger protein 113B

Gene

RNF113B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 218C3H1-typePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri256 – 294RING-typePROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 113B
Alternative name(s):
Zinc finger protein 183-like 1
Gene namesi
Name:RNF113B
Synonyms:RNF161, ZNF183L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139797.7
HGNCiHGNC:17267 RNF113B
neXtProtiNX_Q8IZP6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139797
PharmGKBiPA38217

Polymorphism and mutation databases

BioMutaiRNF113B
DMDMi51338806

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560881 – 322RING finger protein 113BAdd BLAST322

Proteomic databases

EPDiQ8IZP6
MaxQBiQ8IZP6
PaxDbiQ8IZP6
PeptideAtlasiQ8IZP6
PRIDEiQ8IZP6
ProteomicsDBi71393

PTM databases

iPTMnetiQ8IZP6
PhosphoSitePlusiQ8IZP6

Expressioni

Gene expression databases

BgeeiENSG00000139797
CleanExiHS_RNF113B

Interactioni

Protein-protein interaction databases

BioGridi126603, 5 interactors
IntActiQ8IZP6, 3 interactors
STRINGi9606.ENSP00000267291

Structurei

Secondary structure

1322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi257 – 259Combined sources3
Beta strandi265 – 268Combined sources4
Beta strandi274 – 276Combined sources3
Helixi277 – 286Combined sources10
Beta strandi291 – 293Combined sources3
Helixi305 – 311Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSYNMR-A246-313[»]
ProteinModelPortaliQ8IZP6
SMRiQ8IZP6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IZP6

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 218C3H1-typePROSITE-ProRule annotationAdd BLAST29
Zinc fingeri256 – 294RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1813 Eukaryota
COG5152 LUCA
GeneTreeiENSGT00390000016292
HOGENOMiHOG000174759
HOVERGENiHBG060697
InParanoidiQ8IZP6
KOiK15696
OMAiKAPTNIR
OrthoDBiEOG091G0FAM
PhylomeDBiQ8IZP6
TreeFamiTF313469

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IZP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG
60 70 80 90 100
DEGDTVAQPP RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA
110 120 130 140 150
KPVGPEDMGA TADFEQDTEK EHHTPTILKC SQRVQEALRG REHDHIYRGI
160 170 180 190 200
HSYLRYLKPK DTSMGNSSSG MARKGPIRAP GHLRATVRWD YQPDICKDYK
210 220 230 240 250
ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED ENHEVGSEEE
260 270 280 290 300
EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI
310 320
FNPAKELMAK LQKLQAAEGK KR
Length:322
Mass (Da):36,259
Last modified:August 16, 2004 - v3
Checksum:i9D2E63F623150578
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56V → A in AAN33063 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05210492V → M. Corresponds to variant dbSNP:rs16955011Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539427 mRNA Translation: AAN33063.1
AL136300 Genomic DNA No translation available.
BC017585 mRNA Translation: AAH17585.1
BC025388 mRNA Translation: AAH25388.1
CCDSiCCDS9486.1
RefSeqiNP_849192.1, NM_178861.4
UniGeneiHs.296045

Genome annotation databases

EnsembliENST00000267291; ENSP00000267291; ENSG00000139797
GeneIDi140432
KEGGihsa:140432
UCSCiuc001vnk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiR113B_HUMAN
AccessioniPrimary (citable) accession number: Q8IZP6
Secondary accession number(s): Q8WWF9, Q96QY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 16, 2004
Last modified: June 20, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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