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Protein

Putative protein FAM10A4

Gene

ST13P4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein FAM10A4
Alternative name(s):
Suppression of tumorigenicity 13 pseudogene 4
Gene namesi
Name:ST13P4
Synonyms:FAM10A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:18487. ST13P4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74762505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Putative protein FAM10A4PRO_0000190816Add
BLAST

Proteomic databases

EPDiQ8IZP2.
PaxDbiQ8IZP2.
PRIDEiQ8IZP2.

PTM databases

iPTMnetiQ8IZP2.
SwissPalmiQ8IZP2.

Expressioni

Tissue specificityi

Highly expressed in bone marrow and weakly in placenta, pancreas, heart and HeLa cell line.1 Publication

Organism-specific databases

HPAiHPA047114.
HPA047116.

Interactioni

Protein-protein interaction databases

IntActiQ8IZP2. 1 interaction.
MINTiMINT-1149631.
STRINGi9606.ENSP00000216218.

Structurei

3D structure databases

ProteinModelPortaliQ8IZP2.
SMRiQ8IZP2. Positions 1-40, 74-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati110 – 14334TPR 1Add
BLAST
Repeati145 – 17733TPR 2Add
BLAST
Repeati179 – 21133TPR 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi49 – 10557Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM10 family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1308. Eukaryota.
ENOG410XR19. LUCA.
HOVERGENiHBG002482.
InParanoidiQ8IZP2.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPRKVNELR AFVKMCKKDP SILHTQEMRF LREWVESMGG TATQKAKSEE
60 70 80 90 100
NTKEEKPDSK VEEDLKADEP SSEESDLEID KEGVIEPDTD APQEMGDENA
110 120 130 140 150
EITEEVMDQA NDKKVAAIEA LNDGELQKAI DLFTDAIKLN PRLAILYAKR
160 170 180 190 200
ASVFVKLQKP NAAIRDCDRA IEINPDSAQP YKRRGKAHRL LGHWEEAAHD
210 220 230 240
LALACKFDYD EDASAMLKEV QPRAQKIAEH QRKYERKREE
Length:240
Mass (Da):27,407
Last modified:March 1, 2003 - v1
Checksum:i6D2A849E530944E3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti71 – 711S → L.1 Publication
VAR_023644

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539468 mRNA. Translation: AAN16377.1.
AL157367 Genomic DNA. No translation available.
UniGeneiHs.511834.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539468 mRNA. Translation: AAN16377.1.
AL157367 Genomic DNA. No translation available.
UniGeneiHs.511834.

3D structure databases

ProteinModelPortaliQ8IZP2.
SMRiQ8IZP2. Positions 1-40, 74-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IZP2. 1 interaction.
MINTiMINT-1149631.
STRINGi9606.ENSP00000216218.

PTM databases

iPTMnetiQ8IZP2.
SwissPalmiQ8IZP2.

Polymorphism and mutation databases

DMDMi74762505.

Proteomic databases

EPDiQ8IZP2.
PaxDbiQ8IZP2.
PRIDEiQ8IZP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiST13P4.
HGNCiHGNC:18487. ST13P4.
HPAiHPA047114.
HPA047116.
neXtProtiNX_Q8IZP2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1308. Eukaryota.
ENOG410XR19. LUCA.
HOVERGENiHBG002482.
InParanoidiQ8IZP2.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer."
    Sossey-Alaoui K., Kitamura E., Head K., Cowell J.K.
    Genomics 80:5-7(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT LEU-71.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiST134_HUMAN
AccessioniPrimary (citable) accession number: Q8IZP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.