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Q8IZN7 (D107A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 107
Alternative name(s):
Beta-defensin 7
Short name=BD-7
Short name=DEFB-7
Defensin, beta 107
Gene names
Name:DEFB107A
Synonyms:DEFB107, DEFB7
AND
Name:DEFB107B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length70 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity Potential.

Subcellular location

Secreted.

Tissue specificity

Specifically expressed in testis.

Sequence similarities

Belongs to the beta-defensin family.

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.

Sequence caution

The sequence AAZ81951.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Peptide27 – 7044Beta-defensin 107
PRO_0000006979

Amino acid modifications

Disulfide bond41 ↔ 55 By similarity
Disulfide bond45 ↔ 64 By similarity

Experimental info

Sequence conflict91V → F in AAM93909. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q8IZN7 [UniParc].

Last modified April 14, 2009. Version 3.
Checksum: 5A68683397E7ACCB

FASTA707,846
        10         20         30         40         50         60 
MPGAMKIFVF ILAALILLAQ IFQARTAIHR ALISKRMEGH CEAECLTFEV KIGGCRAELA 

        70 
PFCCKNRKKH 

« Hide

References

« Hide 'large scale' references
[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Duplication and selection in the evolution of primate beta-defensin genes."
Semple C.A.M., Rolfe M., Dorin J.R.
Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-67.
[5]"Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-64.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ119826 mRNA. Translation: AAZ81951.1. Different initiation.
AC134684 Genomic DNA. No translation available.
BC137510 mRNA. Translation: AAI37511.1.
BC137513 mRNA. Translation: AAI37514.1.
AF540979 mRNA. Translation: AAN33115.1.
AY122467 mRNA. Translation: AAM93909.1.
RefSeqNP_001032757.2. NM_001037668.1.
NP_001035795.1. NM_001040705.1.
UniGeneHs.520874.
Hs.713490.

3D structure databases

ProteinModelPortalQ8IZN7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000334681.

Polymorphism databases

DMDM226694192.

Proteomic databases

PRIDEQ8IZN7.

Protocols and materials databases

DNASU503614.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335021; ENSP00000334681; ENSG00000186572.
ENST00000355602; ENSP00000347810; ENSG00000198129.
GeneID245910.
503614.
KEGGhsa:245910.
hsa:503614.
UCSCuc003wrq.1. human.

Organism-specific databases

CTD245910.
503614.
GeneCardsGC08M007673.
GC08P007365.
HGNCHGNC:18086. DEFB107A.
HGNC:31918. DEFB107B.
HPAHPA045626.
neXtProtNX_Q8IZN7.
PharmGKBPA142671993.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69854.
HOGENOMHOG000060104.
HOVERGENHBG081401.
InParanoidQ8IZN7.
OMAGRCEAEC.
OrthoDBEOG73Z2X8.
PhylomeDBQ8IZN7.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ8IZN7.
CleanExHS_DEFB107A.
HS_DEFB107B.
GenevestigatorQ8IZN7.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio91753.
PROQ8IZN7.

Entry information

Entry nameD107A_HUMAN
AccessionPrimary (citable) accession number: Q8IZN7
Secondary accession number(s): B2RPM1, Q30E75, Q8NET2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: April 14, 2009
Last modified: April 16, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM