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Protein

Beta-defensin 107

Gene

DEFB107A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 107
Alternative name(s):
Beta-defensin 7
Short name:
BD-7
Short name:
DEFB-7
Defensin, beta 107
Gene namesi
Name:DEFB107A
Synonyms:DEFB107, DEFB7
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000186572.2
HostDB:ENSG00000198129.2
HGNCiHGNC:18086 DEFB107A
HGNC:31918 DEFB107B
neXtProtiNX_Q8IZN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi245910
503614
OpenTargetsiENSG00000186572
PharmGKBiPA142671993

Polymorphism and mutation databases

BioMutaiDEFB107A
DMDMi226694192

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PeptideiPRO_000000697927 – 70Beta-defensin 107Add BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 55By similarity
Disulfide bondi45 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8IZN7
PRIDEiQ8IZN7
ProteomicsDBi71379

Expressioni

Tissue specificityi

Specifically expressed in testis.

Gene expression databases

BgeeiENSG00000186572
CleanExiHS_DEFB107A
HS_DEFB107B
GenevisibleiQ8IZN7 HS

Organism-specific databases

HPAiHPA045626

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347810

Structurei

3D structure databases

ProteinModelPortaliQ8IZN7
SMRiQ8IZN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4YX Eukaryota
ENOG41115P6 LUCA
GeneTreeiENSGT00390000013953
HOGENOMiHOG000060104
HOVERGENiHBG081401
InParanoidiQ8IZN7
OMAiGAMKIFF
OrthoDBiEOG091G19JN
PhylomeDBiQ8IZN7

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAMKIFVF ILAALILLAQ IFQARTAIHR ALISKRMEGH CEAECLTFEV
60 70
KIGGCRAELA PFCCKNRKKH
Length:70
Mass (Da):7,846
Last modified:April 14, 2009 - v3
Checksum:i5A68683397E7ACCB
GO

Sequence cautioni

The sequence AAZ81951 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → F in AAM93909 (PubMed:11854508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119826 mRNA Translation: AAZ81951.1 Different initiation.
AC134684 Genomic DNA No translation available.
BC137510 mRNA Translation: AAI37511.1
BC137513 mRNA Translation: AAI37514.1
AF540979 mRNA Translation: AAN33115.1
AY122467 mRNA Translation: AAM93909.1
CCDSiCCDS43696.1
CCDS43699.1
RefSeqiNP_001032757.2, NM_001037668.1
NP_001035795.1, NM_001040705.1
UniGeneiHs.520874
Hs.713490

Genome annotation databases

EnsembliENST00000335021; ENSP00000334681; ENSG00000186572
ENST00000355602; ENSP00000347810; ENSG00000198129
ENST00000615431; ENSP00000478422; ENSG00000277530
ENST00000642785; ENSP00000495534; ENSG00000285432
ENST00000646983; ENSP00000493774; ENSG00000284979
GeneIDi245910
503614
KEGGihsa:245910
hsa:503614
UCSCiuc003wrq.1 human

Similar proteinsi

Entry informationi

Entry nameiD107A_HUMAN
AccessioniPrimary (citable) accession number: Q8IZN7
Secondary accession number(s): B2RPM1, Q30E75, Q8NET2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: April 14, 2009
Last modified: June 20, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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