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Q8IZN7

- D107A_HUMAN

UniProt

Q8IZN7 - D107A_HUMAN

Protein

Beta-defensin 107

Gene

DEFB107A

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 107
    Alternative name(s):
    Beta-defensin 7
    Short name:
    BD-7
    Short name:
    DEFB-7
    Defensin, beta 107
    Gene namesi
    Name:DEFB107A
    Synonyms:DEFB107, DEFB7
    AND
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:18086. DEFB107A.
    HGNC:31918. DEFB107B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671993.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Peptidei27 – 7044Beta-defensin 107PRO_0000006979Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 55By similarity
    Disulfide bondi45 ↔ 64By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ8IZN7.

    Expressioni

    Tissue specificityi

    Specifically expressed in testis.

    Gene expression databases

    BgeeiQ8IZN7.
    CleanExiHS_DEFB107A.
    HS_DEFB107B.
    GenevestigatoriQ8IZN7.

    Organism-specific databases

    HPAiHPA045626.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334681.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZN7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG69854.
    HOGENOMiHOG000060104.
    HOVERGENiHBG081401.
    InParanoidiQ8IZN7.
    OMAiCLSFEVK.
    OrthoDBiEOG73Z2X8.
    PhylomeDBiQ8IZN7.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8IZN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGAMKIFVF ILAALILLAQ IFQARTAIHR ALISKRMEGH CEAECLTFEV   50
    KIGGCRAELA PFCCKNRKKH 70
    Length:70
    Mass (Da):7,846
    Last modified:April 14, 2009 - v3
    Checksum:i5A68683397E7ACCB
    GO

    Sequence cautioni

    The sequence AAZ81951.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91V → F in AAM93909. (PubMed:11854508)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ119826 mRNA. Translation: AAZ81951.1. Different initiation.
    AC134684 Genomic DNA. No translation available.
    BC137510 mRNA. Translation: AAI37511.1.
    BC137513 mRNA. Translation: AAI37514.1.
    AF540979 mRNA. Translation: AAN33115.1.
    AY122467 mRNA. Translation: AAM93909.1.
    CCDSiCCDS43696.1.
    CCDS43699.1.
    RefSeqiNP_001032757.2. NM_001037668.1.
    NP_001035795.1. NM_001040705.1.
    UniGeneiHs.520874.
    Hs.713490.

    Genome annotation databases

    EnsembliENST00000335021; ENSP00000334681; ENSG00000186572.
    ENST00000355602; ENSP00000347810; ENSG00000198129.
    GeneIDi245910.
    503614.
    KEGGihsa:245910.
    hsa:503614.
    UCSCiuc003wrq.1. human.

    Polymorphism databases

    DMDMi226694192.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ119826 mRNA. Translation: AAZ81951.1 . Different initiation.
    AC134684 Genomic DNA. No translation available.
    BC137510 mRNA. Translation: AAI37511.1 .
    BC137513 mRNA. Translation: AAI37514.1 .
    AF540979 mRNA. Translation: AAN33115.1 .
    AY122467 mRNA. Translation: AAM93909.1 .
    CCDSi CCDS43696.1.
    CCDS43699.1.
    RefSeqi NP_001032757.2. NM_001037668.1.
    NP_001035795.1. NM_001040705.1.
    UniGenei Hs.520874.
    Hs.713490.

    3D structure databases

    ProteinModelPortali Q8IZN7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334681.

    Polymorphism databases

    DMDMi 226694192.

    Proteomic databases

    PRIDEi Q8IZN7.

    Protocols and materials databases

    DNASUi 503614.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335021 ; ENSP00000334681 ; ENSG00000186572 .
    ENST00000355602 ; ENSP00000347810 ; ENSG00000198129 .
    GeneIDi 245910.
    503614.
    KEGGi hsa:245910.
    hsa:503614.
    UCSCi uc003wrq.1. human.

    Organism-specific databases

    CTDi 245910.
    503614.
    GeneCardsi GC08M007673.
    GC08P007365.
    HGNCi HGNC:18086. DEFB107A.
    HGNC:31918. DEFB107B.
    HPAi HPA045626.
    neXtProti NX_Q8IZN7.
    PharmGKBi PA142671993.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69854.
    HOGENOMi HOG000060104.
    HOVERGENi HBG081401.
    InParanoidi Q8IZN7.
    OMAi CLSFEVK.
    OrthoDBi EOG73Z2X8.
    PhylomeDBi Q8IZN7.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    NextBioi 91753.
    PROi Q8IZN7.

    Gene expression databases

    Bgeei Q8IZN7.
    CleanExi HS_DEFB107A.
    HS_DEFB107B.
    Genevestigatori Q8IZN7.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Duplication and selection in the evolution of primate beta-defensin genes."
      Semple C.A.M., Rolfe M., Dorin J.R.
      Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-67.
    5. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
      Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-64.
      Tissue: Testis.

    Entry informationi

    Entry nameiD107A_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZN7
    Secondary accession number(s): B2RPM1, Q30E75, Q8NET2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 90 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-5 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3