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Protein

Beta-defensin 107

Gene

DEFB107A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 107
Alternative name(s):
Beta-defensin 7
Short name:
BD-7
Short name:
DEFB-7
Defensin, beta 107
Gene namesi
Name:DEFB107A
Synonyms:DEFB107, DEFB7
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 8, Unplaced

Organism-specific databases

HGNCiHGNC:18086. DEFB107A.
HGNC:31918. DEFB107B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671993.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Peptidei27 – 7044Beta-defensin 107PRO_0000006979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 55By similarity
Disulfide bondi45 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8IZN7.

Expressioni

Tissue specificityi

Specifically expressed in testis.

Gene expression databases

BgeeiQ8IZN7.
CleanExiHS_DEFB107A.
HS_DEFB107B.
GenevestigatoriQ8IZN7.

Organism-specific databases

HPAiHPA045626.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334681.

Structurei

3D structure databases

ProteinModelPortaliQ8IZN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG69854.
GeneTreeiENSGT00390000013953.
HOGENOMiHOG000060104.
HOVERGENiHBG081401.
InParanoidiQ8IZN7.
OMAiGRCEAEC.
OrthoDBiEOG73Z2X8.
PhylomeDBiQ8IZN7.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAMKIFVF ILAALILLAQ IFQARTAIHR ALISKRMEGH CEAECLTFEV
60 70
KIGGCRAELA PFCCKNRKKH
Length:70
Mass (Da):7,846
Last modified:April 13, 2009 - v3
Checksum:i5A68683397E7ACCB
GO

Sequence cautioni

The sequence AAZ81951.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → F in AAM93909 (PubMed:11854508).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119826 mRNA. Translation: AAZ81951.1. Different initiation.
AC134684 Genomic DNA. No translation available.
BC137510 mRNA. Translation: AAI37511.1.
BC137513 mRNA. Translation: AAI37514.1.
AF540979 mRNA. Translation: AAN33115.1.
AY122467 mRNA. Translation: AAM93909.1.
CCDSiCCDS43696.1.
CCDS43699.1.
RefSeqiNP_001032757.2. NM_001037668.1.
NP_001035795.1. NM_001040705.1.
UniGeneiHs.520874.
Hs.713490.

Genome annotation databases

EnsembliENST00000335021; ENSP00000334681; ENSG00000186572.
ENST00000355602; ENSP00000347810; ENSG00000198129.
ENST00000615431; ENSP00000478422; ENSG00000277530.
GeneIDi245910.
503614.
KEGGihsa:245910.
hsa:503614.
UCSCiuc003wrq.1. human.

Polymorphism databases

DMDMi226694192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119826 mRNA. Translation: AAZ81951.1. Different initiation.
AC134684 Genomic DNA. No translation available.
BC137510 mRNA. Translation: AAI37511.1.
BC137513 mRNA. Translation: AAI37514.1.
AF540979 mRNA. Translation: AAN33115.1.
AY122467 mRNA. Translation: AAM93909.1.
CCDSiCCDS43696.1.
CCDS43699.1.
RefSeqiNP_001032757.2. NM_001037668.1.
NP_001035795.1. NM_001040705.1.
UniGeneiHs.520874.
Hs.713490.

3D structure databases

ProteinModelPortaliQ8IZN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334681.

Polymorphism databases

DMDMi226694192.

Proteomic databases

PRIDEiQ8IZN7.

Protocols and materials databases

DNASUi503614.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335021; ENSP00000334681; ENSG00000186572.
ENST00000355602; ENSP00000347810; ENSG00000198129.
ENST00000615431; ENSP00000478422; ENSG00000277530.
GeneIDi245910.
503614.
KEGGihsa:245910.
hsa:503614.
UCSCiuc003wrq.1. human.

Organism-specific databases

CTDi245910.
503614.
GeneCardsiGC08M007673.
GC08P007367.
HGNCiHGNC:18086. DEFB107A.
HGNC:31918. DEFB107B.
HPAiHPA045626.
neXtProtiNX_Q8IZN7.
PharmGKBiPA142671993.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG69854.
GeneTreeiENSGT00390000013953.
HOGENOMiHOG000060104.
HOVERGENiHBG081401.
InParanoidiQ8IZN7.
OMAiGRCEAEC.
OrthoDBiEOG73Z2X8.
PhylomeDBiQ8IZN7.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

NextBioi91753.
PROiQ8IZN7.

Gene expression databases

BgeeiQ8IZN7.
CleanExiHS_DEFB107A.
HS_DEFB107B.
GenevestigatoriQ8IZN7.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Duplication and selection in the evolution of primate beta-defensin genes."
    Semple C.A.M., Rolfe M., Dorin J.R.
    Genome Biol. 4:R31.1-R31.11(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-67.
  5. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
    Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-64.
    Tissue: Testis.

Entry informationi

Entry nameiD107A_HUMAN
AccessioniPrimary (citable) accession number: Q8IZN7
Secondary accession number(s): B2RPM1, Q30E75, Q8NET2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 25, 2003
Last sequence update: April 13, 2009
Last modified: January 6, 2015
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.