Q8IZN7 (D107A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 107

Alternative name(s):
Beta-defensin 7
Short name=BD-7
Short name=DEFB-7
Defensin, beta 107

Gene names

Name:	DEFB107A
Synonyms:	DEFB107, DEFB7
AND
Name:	DEFB107B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted.
Tissue specificity	Specifically expressed in testis.
Sequence similarities	Belongs to the beta-defensin family.
Caution	It is uncertain whether Met-1 or Met-5 is the initiator.
Sequence caution	The sequence AAZ81951.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Peptide	27 – 70	44	Beta-defensin 107		PRO_0000006979
Amino acid modifications
	Disulfide bond	41 ↔ 55		By similarity
	Disulfide bond	45 ↔ 64		By similarity
Experimental info
	Sequence conflict	9	1	V → F in AAM93909. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q8IZN7 [UniParc]. Last modified April 14, 2009. Version 3. Checksum: 5A68683397E7ACCB	FASTA	70	7,846
	10 20 30 40 50 60 MPGAMKIFVF ILAALILLAQ IFQARTAIHR ALISKRMEGH CEAECLTFEV KIGGCRAELA 70 PFCCKNRKKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract." Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G. Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Duplication and selection in the evolution of primate beta-defensin genes." Semple C.A.M., Rolfe M., Dorin J.R. Genome Biol. 4:R31.1-R31.11(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-67.
[5]	"Discovery of five conserved beta-defensin gene clusters using a computational search strategy." Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr. Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-64. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ119826 mRNA. Translation: AAZ81951.1. Different initiation. AC134684 Genomic DNA. No translation available. BC137510 mRNA. Translation: AAI37511.1. BC137513 mRNA. Translation: AAI37514.1. AF540979 mRNA. Translation: AAN33115.1. AY122467 mRNA. Translation: AAM93909.1.
IPI	IPI00218032.
RefSeq	NP_001032757.2. NM_001037668.1. NP_001035795.1. NM_001040705.1.
UniGene	Hs.520874. Hs.713490.
3D structure databases
ProteinModelPortal	Q8IZN7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000334681.
Protocols and materials databases
DNASU	503614.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335021; ENSP00000334681; ENSG00000186572. ENST00000355602; ENSP00000347810; ENSG00000198129.
GeneID	245910. 503614.
KEGG	hsa:245910. hsa:503614.
UCSC	uc003wrq.1. human.
Organism-specific databases
CTD	245910. 503614.
GeneCards	GC08M007673. GC08P007355.
HGNC	HGNC:18086. DEFB107A. HGNC:31918. DEFB107B.
HPA	HPA045626.
neXtProt	NX_Q8IZN7.
PharmGKB	PA142671993.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG69854.
HOGENOM	HOG000060104.
HOVERGEN	HBG081401.
InParanoid	Q8IZN7.
OMA	GRCEAEC.
OrthoDB	EOG480HZG.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	Q8IZN7.
CleanEx	HS_DEFB107A. HS_DEFB107B.
Genevestigator	Q8IZN7.
GermOnline	ENSG00000186572. Homo sapiens. ENSG00000198129. Homo sapiens.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91753.

Entry information

Entry name

D107A_HUMAN

Accession

Primary (citable) accession number: Q8IZN7
Secondary accession number(s): B2RPM1, Q30E75, Q8NET2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	April 14, 2009
Last modified:	April 3, 2013
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.