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Q8IZN3

- ZDH14_HUMAN

UniProt

Q8IZN3 - ZDH14_HUMAN

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Protein

Probable palmitoyltransferase ZDHHC14

Gene

ZDHHC14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei195 – 1951S-palmitoyl cysteine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri165 – 21551DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. palmitoyltransferase activity Source: UniProt
  2. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein palmitoylation Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC14 (EC:2.3.1.225)
Alternative name(s):
NEW1 domain-containing protein
Short name:
NEW1CP
Zinc finger DHHC domain-containing protein 14
Short name:
DHHC-14
Gene namesi
Name:ZDHHC14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20341. ZDHHC14.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Probable palmitoyltransferase ZDHHC14PRO_0000212891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei455 – 4551Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IZN3.
PaxDbiQ8IZN3.
PRIDEiQ8IZN3.

PTM databases

PhosphoSiteiQ8IZN3.

Expressioni

Gene expression databases

BgeeiQ8IZN3.
CleanExiHS_ZDHHC14.
ExpressionAtlasiQ8IZN3. baseline and differential.
GenevestigatoriQ8IZN3.

Organism-specific databases

HPAiHPA046033.

Interactioni

Protein-protein interaction databases

BioGridi122806. 1 interaction.
STRINGi9606.ENSP00000352821.

Structurei

3D structure databases

ProteinModelPortaliQ8IZN3.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri165 – 21551DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5273.
GeneTreeiENSGT00550000074293.
HOVERGENiHBG056239.
InParanoidiQ8IZN3.
KOiK16675.
OMAiHVGHQFL.
OrthoDBiEOG700882.
PhylomeDBiQ8IZN3.
TreeFamiTF312923.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZN3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPGGGGPMK DCEYSQISTH SSSPMESPHK KKKIAARRKW EVFPGRNKFF
60 70 80 90 100
CNGRIMMARQ TGVFYLTLVL ILVTSGLFFA FDCPYLAVKI TPAIPAVAGI
110 120 130 140 150
LFFFVMGTLL RTSFSDPGVL PRATPDEAAD LERQIDIANG TSSGGYRPPP
160 170 180 190 200
RTKEVIINGQ TVKLKYCFTC KIFRPPRASH CSLCDNCVER FDHHCPWVGN
210 220 230 240 250
CVGKRNYRFF YMFILSLSFL TVFIFAFVIT HVILRSQQTG FLNALKDSPA
260 270 280 290 300
SVLEAVVCFF SVWSIVGLSG FHTYLISSNQ TTNEDIKGSW SNKRGKENYN
310 320 330 340 350
PYSYGNIFTN CCVALCGPIS PSLIDRRGYI QPDTPQPAAP SNGITMYGAT
360 370 380 390 400
QSQSDMCDQD QCIQSTKFVL QAAATPLLQS EPSLTSDELH LPGKPGLGTP
410 420 430 440 450
CASLTLGPPT PPASMPNLAE ATLADVMPRK DEHMGHQFLT PDEAPSPPRL
460 470 480
LAAGSPLAHS RTMHVLGLAS QDSLHEDSVR GLVKLSSV
Length:488
Mass (Da):53,388
Last modified:March 1, 2003 - v1
Checksum:iB50CCDE1B738C135
GO
Isoform 2 (identifier: Q8IZN3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     357-371: Missing.

Show »
Length:473
Mass (Da):51,651
Checksum:i534ACF9D9113B79E
GO

Sequence cautioni

The sequence BAB14941.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti334 – 3341T → M.
Corresponds to variant rs8180688 [ dbSNP | Ensembl ].
VAR_034586

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei357 – 37115Missing in isoform 2. 1 PublicationVSP_008651Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF542388 mRNA. Translation: AAN47142.1.
AF542389 mRNA. Translation: AAN47143.1.
AL450328, AL133510 Genomic DNA. Translation: CAI39698.1.
AL133510, AL450328 Genomic DNA. Translation: CAI42852.1.
AL450328, AL117344, AL133510 Genomic DNA. Translation: CAI39699.1.
AL133510, AL117344, AL450328 Genomic DNA. Translation: CAI42853.1.
AL117344, AL133510, AL450328 Genomic DNA. Translation: CAI20404.1.
CH471051 Genomic DNA. Translation: EAW47671.1.
AK024637 mRNA. Translation: BAB14941.1. Different initiation.
BC056399 mRNA. Translation: AAH56399.1.
CCDSiCCDS47510.1. [Q8IZN3-2]
CCDS5252.1. [Q8IZN3-1]
RefSeqiNP_078906.2. NM_024630.2. [Q8IZN3-1]
NP_714968.1. NM_153746.1. [Q8IZN3-2]
UniGeneiHs.596214.
Hs.745003.

Genome annotation databases

EnsembliENST00000359775; ENSP00000352821; ENSG00000175048. [Q8IZN3-1]
ENST00000414563; ENSP00000410713; ENSG00000175048. [Q8IZN3-2]
GeneIDi79683.
KEGGihsa:79683.
UCSCiuc003qqs.3. human. [Q8IZN3-2]
uc003qqt.3. human. [Q8IZN3-1]

Polymorphism databases

DMDMi37999849.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF542388 mRNA. Translation: AAN47142.1 .
AF542389 mRNA. Translation: AAN47143.1 .
AL450328 , AL133510 Genomic DNA. Translation: CAI39698.1 .
AL133510 , AL450328 Genomic DNA. Translation: CAI42852.1 .
AL450328 , AL117344 , AL133510 Genomic DNA. Translation: CAI39699.1 .
AL133510 , AL117344 , AL450328 Genomic DNA. Translation: CAI42853.1 .
AL117344 , AL133510 , AL450328 Genomic DNA. Translation: CAI20404.1 .
CH471051 Genomic DNA. Translation: EAW47671.1 .
AK024637 mRNA. Translation: BAB14941.1 . Different initiation.
BC056399 mRNA. Translation: AAH56399.1 .
CCDSi CCDS47510.1. [Q8IZN3-2 ]
CCDS5252.1. [Q8IZN3-1 ]
RefSeqi NP_078906.2. NM_024630.2. [Q8IZN3-1 ]
NP_714968.1. NM_153746.1. [Q8IZN3-2 ]
UniGenei Hs.596214.
Hs.745003.

3D structure databases

ProteinModelPortali Q8IZN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122806. 1 interaction.
STRINGi 9606.ENSP00000352821.

PTM databases

PhosphoSitei Q8IZN3.

Polymorphism databases

DMDMi 37999849.

Proteomic databases

MaxQBi Q8IZN3.
PaxDbi Q8IZN3.
PRIDEi Q8IZN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359775 ; ENSP00000352821 ; ENSG00000175048 . [Q8IZN3-1 ]
ENST00000414563 ; ENSP00000410713 ; ENSG00000175048 . [Q8IZN3-2 ]
GeneIDi 79683.
KEGGi hsa:79683.
UCSCi uc003qqs.3. human. [Q8IZN3-2 ]
uc003qqt.3. human. [Q8IZN3-1 ]

Organism-specific databases

CTDi 79683.
GeneCardsi GC06P157772.
HGNCi HGNC:20341. ZDHHC14.
HPAi HPA046033.
neXtProti NX_Q8IZN3.
PharmGKBi PA134935513.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5273.
GeneTreei ENSGT00550000074293.
HOVERGENi HBG056239.
InParanoidi Q8IZN3.
KOi K16675.
OMAi HVGHQFL.
OrthoDBi EOG700882.
PhylomeDBi Q8IZN3.
TreeFami TF312923.

Miscellaneous databases

ChiTaRSi ZDHHC14. human.
GenomeRNAii 79683.
NextBioi 68938.
PROi Q8IZN3.

Gene expression databases

Bgeei Q8IZN3.
CleanExi HS_ZDHHC14.
ExpressionAtlasi Q8IZN3. baseline and differential.
Genevestigatori Q8IZN3.

Family and domain databases

InterProi IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view ]
Pfami PF01529. zf-DHHC. 1 hit.
[Graphical view ]
PROSITEi PS50216. ZF_DHHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Guo J.H., Chen L., Yu L.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Stomach.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-488 (ISOFORM 1).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 288-488 (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZDH14_HUMAN
AccessioniPrimary (citable) accession number: Q8IZN3
Secondary accession number(s): A6NDB7
, Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q9H7F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3