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Q8IZN3

- ZDH14_HUMAN

UniProt

Q8IZN3 - ZDH14_HUMAN

Protein

Probable palmitoyltransferase ZDHHC14

Gene

ZDHHC14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei195 – 1951S-palmitoyl cysteine intermediateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri165 – 21551DHHC-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. palmitoyltransferase activity Source: UniProt
    2. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein palmitoylation Source: UniProt

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable palmitoyltransferase ZDHHC14 (EC:2.3.1.225)
    Alternative name(s):
    NEW1 domain-containing protein
    Short name:
    NEW1CP
    Zinc finger DHHC domain-containing protein 14
    Short name:
    DHHC-14
    Gene namesi
    Name:ZDHHC14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20341. ZDHHC14.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134935513.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Probable palmitoyltransferase ZDHHC14PRO_0000212891Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei455 – 4551Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8IZN3.
    PRIDEiQ8IZN3.

    PTM databases

    PhosphoSiteiQ8IZN3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IZN3.
    BgeeiQ8IZN3.
    CleanExiHS_ZDHHC14.
    GenevestigatoriQ8IZN3.

    Organism-specific databases

    HPAiHPA046033.

    Interactioni

    Protein-protein interaction databases

    BioGridi122806. 1 interaction.
    STRINGi9606.ENSP00000352821.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The DHHC domain is required for palmitoyltransferase activity.By similarity

    Sequence similaritiesi

    Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri165 – 21551DHHC-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5273.
    HOVERGENiHBG056239.
    InParanoidiQ8IZN3.
    KOiK16675.
    OMAiHVGHQFL.
    OrthoDBiEOG700882.
    PhylomeDBiQ8IZN3.
    TreeFamiTF312923.

    Family and domain databases

    InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view]
    PfamiPF01529. zf-DHHC. 1 hit.
    [Graphical view]
    PROSITEiPS50216. ZF_DHHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IZN3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPPGGGGPMK DCEYSQISTH SSSPMESPHK KKKIAARRKW EVFPGRNKFF    50
    CNGRIMMARQ TGVFYLTLVL ILVTSGLFFA FDCPYLAVKI TPAIPAVAGI 100
    LFFFVMGTLL RTSFSDPGVL PRATPDEAAD LERQIDIANG TSSGGYRPPP 150
    RTKEVIINGQ TVKLKYCFTC KIFRPPRASH CSLCDNCVER FDHHCPWVGN 200
    CVGKRNYRFF YMFILSLSFL TVFIFAFVIT HVILRSQQTG FLNALKDSPA 250
    SVLEAVVCFF SVWSIVGLSG FHTYLISSNQ TTNEDIKGSW SNKRGKENYN 300
    PYSYGNIFTN CCVALCGPIS PSLIDRRGYI QPDTPQPAAP SNGITMYGAT 350
    QSQSDMCDQD QCIQSTKFVL QAAATPLLQS EPSLTSDELH LPGKPGLGTP 400
    CASLTLGPPT PPASMPNLAE ATLADVMPRK DEHMGHQFLT PDEAPSPPRL 450
    LAAGSPLAHS RTMHVLGLAS QDSLHEDSVR GLVKLSSV 488
    Length:488
    Mass (Da):53,388
    Last modified:March 1, 2003 - v1
    Checksum:iB50CCDE1B738C135
    GO
    Isoform 2 (identifier: Q8IZN3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         357-371: Missing.

    Show »
    Length:473
    Mass (Da):51,651
    Checksum:i534ACF9D9113B79E
    GO

    Sequence cautioni

    The sequence BAB14941.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti334 – 3341T → M.
    Corresponds to variant rs8180688 [ dbSNP | Ensembl ].
    VAR_034586

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei357 – 37115Missing in isoform 2. 1 PublicationVSP_008651Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF542388 mRNA. Translation: AAN47142.1.
    AF542389 mRNA. Translation: AAN47143.1.
    AL450328, AL133510 Genomic DNA. Translation: CAI39698.1.
    AL133510, AL450328 Genomic DNA. Translation: CAI42852.1.
    AL450328, AL117344, AL133510 Genomic DNA. Translation: CAI39699.1.
    AL133510, AL117344, AL450328 Genomic DNA. Translation: CAI42853.1.
    AL117344, AL133510, AL450328 Genomic DNA. Translation: CAI20404.1.
    CH471051 Genomic DNA. Translation: EAW47671.1.
    AK024637 mRNA. Translation: BAB14941.1. Different initiation.
    BC056399 mRNA. Translation: AAH56399.1.
    CCDSiCCDS47510.1. [Q8IZN3-2]
    CCDS5252.1. [Q8IZN3-1]
    RefSeqiNP_078906.2. NM_024630.2. [Q8IZN3-1]
    NP_714968.1. NM_153746.1. [Q8IZN3-2]
    UniGeneiHs.596214.
    Hs.745003.

    Genome annotation databases

    EnsembliENST00000359775; ENSP00000352821; ENSG00000175048. [Q8IZN3-1]
    ENST00000414563; ENSP00000410713; ENSG00000175048. [Q8IZN3-2]
    GeneIDi79683.
    KEGGihsa:79683.
    UCSCiuc003qqs.3. human. [Q8IZN3-2]
    uc003qqt.3. human. [Q8IZN3-1]

    Polymorphism databases

    DMDMi37999849.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF542388 mRNA. Translation: AAN47142.1 .
    AF542389 mRNA. Translation: AAN47143.1 .
    AL450328 , AL133510 Genomic DNA. Translation: CAI39698.1 .
    AL133510 , AL450328 Genomic DNA. Translation: CAI42852.1 .
    AL450328 , AL117344 , AL133510 Genomic DNA. Translation: CAI39699.1 .
    AL133510 , AL117344 , AL450328 Genomic DNA. Translation: CAI42853.1 .
    AL117344 , AL133510 , AL450328 Genomic DNA. Translation: CAI20404.1 .
    CH471051 Genomic DNA. Translation: EAW47671.1 .
    AK024637 mRNA. Translation: BAB14941.1 . Different initiation.
    BC056399 mRNA. Translation: AAH56399.1 .
    CCDSi CCDS47510.1. [Q8IZN3-2 ]
    CCDS5252.1. [Q8IZN3-1 ]
    RefSeqi NP_078906.2. NM_024630.2. [Q8IZN3-1 ]
    NP_714968.1. NM_153746.1. [Q8IZN3-2 ]
    UniGenei Hs.596214.
    Hs.745003.

    3D structure databases

    ProteinModelPortali Q8IZN3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122806. 1 interaction.
    STRINGi 9606.ENSP00000352821.

    PTM databases

    PhosphoSitei Q8IZN3.

    Polymorphism databases

    DMDMi 37999849.

    Proteomic databases

    PaxDbi Q8IZN3.
    PRIDEi Q8IZN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359775 ; ENSP00000352821 ; ENSG00000175048 . [Q8IZN3-1 ]
    ENST00000414563 ; ENSP00000410713 ; ENSG00000175048 . [Q8IZN3-2 ]
    GeneIDi 79683.
    KEGGi hsa:79683.
    UCSCi uc003qqs.3. human. [Q8IZN3-2 ]
    uc003qqt.3. human. [Q8IZN3-1 ]

    Organism-specific databases

    CTDi 79683.
    GeneCardsi GC06P157772.
    HGNCi HGNC:20341. ZDHHC14.
    HPAi HPA046033.
    neXtProti NX_Q8IZN3.
    PharmGKBi PA134935513.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5273.
    HOVERGENi HBG056239.
    InParanoidi Q8IZN3.
    KOi K16675.
    OMAi HVGHQFL.
    OrthoDBi EOG700882.
    PhylomeDBi Q8IZN3.
    TreeFami TF312923.

    Miscellaneous databases

    ChiTaRSi ZDHHC14. human.
    GenomeRNAii 79683.
    NextBioi 68938.
    PROi Q8IZN3.

    Gene expression databases

    ArrayExpressi Q8IZN3.
    Bgeei Q8IZN3.
    CleanExi HS_ZDHHC14.
    Genevestigatori Q8IZN3.

    Family and domain databases

    InterProi IPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view ]
    Pfami PF01529. zf-DHHC. 1 hit.
    [Graphical view ]
    PROSITEi PS50216. ZF_DHHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Guo J.H., Chen L., Yu L.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Stomach.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-488 (ISOFORM 1).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 288-488 (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiZDH14_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZN3
    Secondary accession number(s): A6NDB7
    , Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q9H7F1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3