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Q8IZN3 (ZDH14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable palmitoyltransferase ZDHHC14

EC=2.3.1.225
Alternative name(s):
NEW1 domain-containing protein
Short name=NEW1CP
Zinc finger DHHC domain-containing protein 14
Short name=DHHC-14
Gene names
Name:ZDHHC14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Domain

The DHHC domain is required for palmitoyltransferase activity By similarity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.

Contains 1 DHHC-type zinc finger.

Sequence caution

The sequence BAB14941.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IZN3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IZN3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     357-371: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Probable palmitoyltransferase ZDHHC14
PRO_0000212891

Regions

Transmembrane61 – 8121Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane256 – 27621Helical; Potential
Zinc finger165 – 21551DHHC-type

Sites

Active site1951S-palmitoyl cysteine intermediate By similarity

Amino acid modifications

Modified residue4551Phosphoserine Ref.6 Ref.7

Natural variations

Alternative sequence357 – 37115Missing in isoform 2.
VSP_008651
Natural variant3341T → M.
Corresponds to variant rs8180688 [ dbSNP | Ensembl ].
VAR_034586

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B50CCDE1B738C135

FASTA48853,388
        10         20         30         40         50         60 
MPPGGGGPMK DCEYSQISTH SSSPMESPHK KKKIAARRKW EVFPGRNKFF CNGRIMMARQ 

        70         80         90        100        110        120 
TGVFYLTLVL ILVTSGLFFA FDCPYLAVKI TPAIPAVAGI LFFFVMGTLL RTSFSDPGVL 

       130        140        150        160        170        180 
PRATPDEAAD LERQIDIANG TSSGGYRPPP RTKEVIINGQ TVKLKYCFTC KIFRPPRASH 

       190        200        210        220        230        240 
CSLCDNCVER FDHHCPWVGN CVGKRNYRFF YMFILSLSFL TVFIFAFVIT HVILRSQQTG 

       250        260        270        280        290        300 
FLNALKDSPA SVLEAVVCFF SVWSIVGLSG FHTYLISSNQ TTNEDIKGSW SNKRGKENYN 

       310        320        330        340        350        360 
PYSYGNIFTN CCVALCGPIS PSLIDRRGYI QPDTPQPAAP SNGITMYGAT QSQSDMCDQD 

       370        380        390        400        410        420 
QCIQSTKFVL QAAATPLLQS EPSLTSDELH LPGKPGLGTP CASLTLGPPT PPASMPNLAE 

       430        440        450        460        470        480 
ATLADVMPRK DEHMGHQFLT PDEAPSPPRL LAAGSPLAHS RTMHVLGLAS QDSLHEDSVR 


GLVKLSSV 

« Hide

Isoform 2 [UniParc].

Checksum: 534ACF9D9113B79E
Show »

FASTA47351,651

References

[1]Guo J.H., Chen L., Yu L.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Stomach.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-488 (ISOFORM 1).
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 288-488 (ISOFORM 1).
Tissue: Brain.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF542388 mRNA. Translation: AAN47142.1.
AF542389 mRNA. Translation: AAN47143.1.
AL450328, AL133510 Genomic DNA. Translation: CAI39698.1.
AL133510, AL450328 Genomic DNA. Translation: CAI42852.1.
AL450328, AL117344, AL133510 Genomic DNA. Translation: CAI39699.1.
AL133510, AL117344, AL450328 Genomic DNA. Translation: CAI42853.1.
AL117344, AL133510, AL450328 Genomic DNA. Translation: CAI20404.1.
CH471051 Genomic DNA. Translation: EAW47671.1.
AK024637 mRNA. Translation: BAB14941.1. Different initiation.
BC056399 mRNA. Translation: AAH56399.1.
CCDSCCDS47510.1. [Q8IZN3-2]
CCDS5252.1. [Q8IZN3-1]
RefSeqNP_078906.2. NM_024630.2. [Q8IZN3-1]
NP_714968.1. NM_153746.1. [Q8IZN3-2]
UniGeneHs.596214.
Hs.745003.

3D structure databases

ProteinModelPortalQ8IZN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122806. 1 interaction.
STRING9606.ENSP00000352821.

PTM databases

PhosphoSiteQ8IZN3.

Polymorphism databases

DMDM37999849.

Proteomic databases

PaxDbQ8IZN3.
PRIDEQ8IZN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359775; ENSP00000352821; ENSG00000175048. [Q8IZN3-1]
ENST00000414563; ENSP00000410713; ENSG00000175048. [Q8IZN3-2]
GeneID79683.
KEGGhsa:79683.
UCSCuc003qqs.3. human. [Q8IZN3-2]
uc003qqt.3. human. [Q8IZN3-1]

Organism-specific databases

CTD79683.
GeneCardsGC06P157772.
HGNCHGNC:20341. ZDHHC14.
HPAHPA046033.
neXtProtNX_Q8IZN3.
PharmGKBPA134935513.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5273.
HOVERGENHBG056239.
InParanoidQ8IZN3.
KOK16675.
OMAHVGHQFL.
OrthoDBEOG700882.
PhylomeDBQ8IZN3.
TreeFamTF312923.

Gene expression databases

ArrayExpressQ8IZN3.
BgeeQ8IZN3.
CleanExHS_ZDHHC14.
GenevestigatorQ8IZN3.

Family and domain databases

InterProIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZDHHC14. human.
GenomeRNAi79683.
NextBio68938.
PROQ8IZN3.

Entry information

Entry nameZDH14_HUMAN
AccessionPrimary (citable) accession number: Q8IZN3
Secondary accession number(s): A6NDB7 expand/collapse secondary AC list , Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q9H7F1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM