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Protein

Probable sodium-coupled neutral amino acid transporter 6

Gene

SLC38A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.18.6.11. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable sodium-coupled neutral amino acid transporter 6
Alternative name(s):
N-system amino acid transporter 1
Short name:
NAT-1
Na(+)-coupled neutral amino acid transporter 6
Solute carrier family 38 member 6
Gene namesi
Name:SLC38A6
Synonyms:NAT1, SNAT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19863. SLC38A6.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Colocalizes with synaptotagmins and SNAP25.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi145389.
OpenTargetsiENSG00000139974.
PharmGKBiPA134932150.

Polymorphism and mutation databases

BioMutaiSLC38A6.
DMDMi296452887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003114211 – 456Probable sodium-coupled neutral amino acid transporter 6Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Glycosylationi233N-linked (GlcNAc...)Sequence analysis1
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8IZM9.
PeptideAtlasiQ8IZM9.
PRIDEiQ8IZM9.

PTM databases

iPTMnetiQ8IZM9.
PhosphoSitePlusiQ8IZM9.

Expressioni

Gene expression databases

BgeeiENSG00000139974.
CleanExiHS_NAT1.
HS_SLC38A6.
ExpressionAtlasiQ8IZM9. baseline and differential.
GenevisibleiQ8IZM9. HS.

Organism-specific databases

HPAiHPA018508.

Interactioni

Protein-protein interaction databases

BioGridi126909. 9 interactors.
STRINGi9606.ENSP00000346959.

Structurei

3D structure databases

ProteinModelPortaliQ8IZM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ8IZM9.
KOiK14993.
OMAiKRMQNAT.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ8IZM9.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEASWGSFNA ERGWYVSVQQ PEEAEAEELS PLLSNELHRQ RSPGVSFGLS
60 70 80 90 100
VFNLMNAIMG SGILGLAYVL ANTGVFGFSF LLLTVALLAS YSVHLLLSMC
110 120 130 140 150
IQTAVTSYED LGLFAFGLPG KLVVAGTIII QNIGAMSSYL LIIKTELPAA
160 170 180 190 200
IAEFLTGDYS RYWYLDGQTL LIIICVGIVF PLALLPKIGF LGYTSSLSFF
210 220 230 240 250
FMMFFALVVI IKKWSIPCPL TLNYVEKGFQ ISNVTDDCKP KLFHFSKESA
260 270 280 290 300
YALPTMAFSF LCHTSILPIY CELQSPSKKR MQNVTNTAIA LSFLIYFISA
310 320 330 340 350
LFGYLTFYDK VESELLKGYS KYLSHDVVVM TVKLCILFAV LLTVPLIHFP
360 370 380 390 400
ARKAVTMMFF SNFPFSWIRH FLITLALNII IVLLAIYVPD IRNVFGVVGA
410 420 430 440 450
STSTCLIFIF PGLFYLKLSR EDFLSWKKLG AFVLLIFGIL VGNFSLALII

FDWINK
Length:456
Mass (Da):50,929
Last modified:May 18, 2010 - v2
Checksum:i007D1339B4FBC618
GO
Isoform 2 (identifier: Q8IZM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-456: AFVLLIFGILVGNFSLALIIFDWINK → GLILSHRLAC...HFPTSRTVSK

Show »
Length:521
Mass (Da):57,930
Checksum:iE7B7F035C7F88904
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03724770L → M.2 PublicationsCorresponds to variant rs976272dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029563431 – 456AFVLL…DWINK → GLILSHRLACSGVISAHCNL CLPDSSNPPTSASRVAETTG RDTMEMCTQRKGHARTQQEG NCLQAKGRGLRRTKRVHTLI LHFPTSRTVSK in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543422 mRNA. Translation: AAN47144.1.
AL160236 Genomic DNA. No translation available.
AL160234 Genomic DNA. No translation available.
BC110378 mRNA. Translation: AAI10379.1.
BX248072 mRNA. Translation: CAD62361.1.
CCDSiCCDS53900.1. [Q8IZM9-2]
CCDS9751.1. [Q8IZM9-1]
RefSeqiNP_001166173.1. NM_001172702.1. [Q8IZM9-2]
NP_722518.2. NM_153811.2. [Q8IZM9-1]
UniGeneiHs.200738.

Genome annotation databases

EnsembliENST00000267488; ENSP00000267488; ENSG00000139974. [Q8IZM9-1]
ENST00000354886; ENSP00000346959; ENSG00000139974. [Q8IZM9-2]
GeneIDi145389.
KEGGihsa:145389.
UCSCiuc001xfg.3. human. [Q8IZM9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543422 mRNA. Translation: AAN47144.1.
AL160236 Genomic DNA. No translation available.
AL160234 Genomic DNA. No translation available.
BC110378 mRNA. Translation: AAI10379.1.
BX248072 mRNA. Translation: CAD62361.1.
CCDSiCCDS53900.1. [Q8IZM9-2]
CCDS9751.1. [Q8IZM9-1]
RefSeqiNP_001166173.1. NM_001172702.1. [Q8IZM9-2]
NP_722518.2. NM_153811.2. [Q8IZM9-1]
UniGeneiHs.200738.

3D structure databases

ProteinModelPortaliQ8IZM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126909. 9 interactors.
STRINGi9606.ENSP00000346959.

Protein family/group databases

TCDBi2.A.18.6.11. the amino acid/auxin permease (aaap) family.

PTM databases

iPTMnetiQ8IZM9.
PhosphoSitePlusiQ8IZM9.

Polymorphism and mutation databases

BioMutaiSLC38A6.
DMDMi296452887.

Proteomic databases

PaxDbiQ8IZM9.
PeptideAtlasiQ8IZM9.
PRIDEiQ8IZM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267488; ENSP00000267488; ENSG00000139974. [Q8IZM9-1]
ENST00000354886; ENSP00000346959; ENSG00000139974. [Q8IZM9-2]
GeneIDi145389.
KEGGihsa:145389.
UCSCiuc001xfg.3. human. [Q8IZM9-1]

Organism-specific databases

CTDi145389.
DisGeNETi145389.
GeneCardsiSLC38A6.
HGNCiHGNC:19863. SLC38A6.
HPAiHPA018508.
MIMi616518. gene.
neXtProtiNX_Q8IZM9.
OpenTargetsiENSG00000139974.
PharmGKBiPA134932150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ8IZM9.
KOiK14993.
OMAiKRMQNAT.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ8IZM9.
TreeFamiTF328787.

Miscellaneous databases

ChiTaRSiSLC38A6. human.
GenomeRNAii145389.
PROiQ8IZM9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139974.
CleanExiHS_NAT1.
HS_SLC38A6.
ExpressionAtlasiQ8IZM9. baseline and differential.
GenevisibleiQ8IZM9. HS.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38A6_HUMAN
AccessioniPrimary (citable) accession number: Q8IZM9
Secondary accession number(s): C9JWA6, Q86SY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.