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Protein

Probable sodium-coupled neutral amino acid transporter 6

Gene

SLC38A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.18.6.11. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable sodium-coupled neutral amino acid transporter 6
Alternative name(s):
N-system amino acid transporter 1
Short name:
NAT-1
Na(+)-coupled neutral amino acid transporter 6
Solute carrier family 38 member 6
Gene namesi
Name:SLC38A6
Synonyms:NAT1, SNAT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19863. SLC38A6.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Colocalizes with synaptotagmins and SNAP25.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence analysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence analysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932150.

Polymorphism and mutation databases

BioMutaiSLC38A6.
DMDMi296452887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Probable sodium-coupled neutral amino acid transporter 6PRO_0000311421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei4 – 41PhosphoserineCombined sources
Modified residuei7 – 71PhosphoserineCombined sources
Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence analysis
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8IZM9.
PRIDEiQ8IZM9.

PTM databases

iPTMnetiQ8IZM9.
PhosphoSiteiQ8IZM9.

Expressioni

Gene expression databases

BgeeiQ8IZM9.
CleanExiHS_NAT1.
HS_SLC38A6.
ExpressionAtlasiQ8IZM9. baseline and differential.
GenevisibleiQ8IZM9. HS.

Organism-specific databases

HPAiHPA018508.

Interactioni

Protein-protein interaction databases

BioGridi126909. 9 interactions.
STRINGi9606.ENSP00000346959.

Structurei

3D structure databases

ProteinModelPortaliQ8IZM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ8IZM9.
KOiK14993.
OMAiKRMQNAT.
OrthoDBiEOG7WHH9J.
PhylomeDBiQ8IZM9.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEASWGSFNA ERGWYVSVQQ PEEAEAEELS PLLSNELHRQ RSPGVSFGLS
60 70 80 90 100
VFNLMNAIMG SGILGLAYVL ANTGVFGFSF LLLTVALLAS YSVHLLLSMC
110 120 130 140 150
IQTAVTSYED LGLFAFGLPG KLVVAGTIII QNIGAMSSYL LIIKTELPAA
160 170 180 190 200
IAEFLTGDYS RYWYLDGQTL LIIICVGIVF PLALLPKIGF LGYTSSLSFF
210 220 230 240 250
FMMFFALVVI IKKWSIPCPL TLNYVEKGFQ ISNVTDDCKP KLFHFSKESA
260 270 280 290 300
YALPTMAFSF LCHTSILPIY CELQSPSKKR MQNVTNTAIA LSFLIYFISA
310 320 330 340 350
LFGYLTFYDK VESELLKGYS KYLSHDVVVM TVKLCILFAV LLTVPLIHFP
360 370 380 390 400
ARKAVTMMFF SNFPFSWIRH FLITLALNII IVLLAIYVPD IRNVFGVVGA
410 420 430 440 450
STSTCLIFIF PGLFYLKLSR EDFLSWKKLG AFVLLIFGIL VGNFSLALII

FDWINK
Length:456
Mass (Da):50,929
Last modified:May 18, 2010 - v2
Checksum:i007D1339B4FBC618
GO
Isoform 2 (identifier: Q8IZM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-456: AFVLLIFGILVGNFSLALIIFDWINK → GLILSHRLAC...HFPTSRTVSK

Show »
Length:521
Mass (Da):57,930
Checksum:iE7B7F035C7F88904
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701L → M.2 Publications
Corresponds to variant rs976272 [ dbSNP | Ensembl ].
VAR_037247

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei431 – 45626AFVLL…DWINK → GLILSHRLACSGVISAHCNL CLPDSSNPPTSASRVAETTG RDTMEMCTQRKGHARTQQEG NCLQAKGRGLRRTKRVHTLI LHFPTSRTVSK in isoform 2. 1 PublicationVSP_029563Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543422 mRNA. Translation: AAN47144.1.
AL160236 Genomic DNA. No translation available.
AL160234 Genomic DNA. No translation available.
BC110378 mRNA. Translation: AAI10379.1.
BX248072 mRNA. Translation: CAD62361.1.
CCDSiCCDS53900.1. [Q8IZM9-2]
CCDS9751.1. [Q8IZM9-1]
RefSeqiNP_001166173.1. NM_001172702.1. [Q8IZM9-2]
NP_722518.2. NM_153811.2. [Q8IZM9-1]
UniGeneiHs.200738.

Genome annotation databases

EnsembliENST00000267488; ENSP00000267488; ENSG00000139974. [Q8IZM9-1]
ENST00000354886; ENSP00000346959; ENSG00000139974. [Q8IZM9-2]
GeneIDi145389.
KEGGihsa:145389.
UCSCiuc001xfg.3. human. [Q8IZM9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543422 mRNA. Translation: AAN47144.1.
AL160236 Genomic DNA. No translation available.
AL160234 Genomic DNA. No translation available.
BC110378 mRNA. Translation: AAI10379.1.
BX248072 mRNA. Translation: CAD62361.1.
CCDSiCCDS53900.1. [Q8IZM9-2]
CCDS9751.1. [Q8IZM9-1]
RefSeqiNP_001166173.1. NM_001172702.1. [Q8IZM9-2]
NP_722518.2. NM_153811.2. [Q8IZM9-1]
UniGeneiHs.200738.

3D structure databases

ProteinModelPortaliQ8IZM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126909. 9 interactions.
STRINGi9606.ENSP00000346959.

Protein family/group databases

TCDBi2.A.18.6.11. the amino acid/auxin permease (aaap) family.

PTM databases

iPTMnetiQ8IZM9.
PhosphoSiteiQ8IZM9.

Polymorphism and mutation databases

BioMutaiSLC38A6.
DMDMi296452887.

Proteomic databases

PaxDbiQ8IZM9.
PRIDEiQ8IZM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267488; ENSP00000267488; ENSG00000139974. [Q8IZM9-1]
ENST00000354886; ENSP00000346959; ENSG00000139974. [Q8IZM9-2]
GeneIDi145389.
KEGGihsa:145389.
UCSCiuc001xfg.3. human. [Q8IZM9-1]

Organism-specific databases

CTDi145389.
GeneCardsiSLC38A6.
HGNCiHGNC:19863. SLC38A6.
HPAiHPA018508.
MIMi616518. gene.
neXtProtiNX_Q8IZM9.
PharmGKBiPA134932150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ8IZM9.
KOiK14993.
OMAiKRMQNAT.
OrthoDBiEOG7WHH9J.
PhylomeDBiQ8IZM9.
TreeFamiTF328787.

Miscellaneous databases

ChiTaRSiSLC38A6. human.
GenomeRNAii145389.
NextBioi85087.
PROiQ8IZM9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZM9.
CleanExiHS_NAT1.
HS_SLC38A6.
ExpressionAtlasiQ8IZM9. baseline and differential.
GenevisibleiQ8IZM9. HS.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Guo J.H., Yu L.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-70.
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-70.
    Tissue: Duodenum.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-456 (ISOFORM 2).
    Tissue: Cervix carcinoma.
  5. "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family."
    Mackenzie B., Erickson J.D.
    Pflugers Arch. 447:784-795(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, NOMENCLATURE.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiS38A6_HUMAN
AccessioniPrimary (citable) accession number: Q8IZM9
Secondary accession number(s): C9JWA6, Q86SY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.