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Protein

Zinc finger protein 654

Gene

ZNF654

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 47C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 224C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri297 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 654
Alternative name(s):
Melanoma-associated antigen
Gene namesi
Name:ZNF654
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25612. ZNF654.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55279.
OpenTargetsiENSG00000175105.
PharmGKBiPA134923001.

Polymorphism and mutation databases

BioMutaiZNF654.
DMDMi296453064.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119461 – 581Zinc finger protein 654Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei576PhosphoserineBy similarity1
Modified residuei580PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IZM8.
MaxQBiQ8IZM8.
PaxDbiQ8IZM8.
PeptideAtlasiQ8IZM8.
PRIDEiQ8IZM8.

PTM databases

iPTMnetiQ8IZM8.
PhosphoSitePlusiQ8IZM8.

Expressioni

Gene expression databases

BgeeiENSG00000175105.
CleanExiHS_ZNF654.
GenevisibleiQ8IZM8. HS.

Organism-specific databases

HPAiHPA036172.
HPA036173.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312141.

Structurei

3D structure databases

ProteinModelPortaliQ8IZM8.
SMRiQ8IZM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 80Poly-Ser6
Compositional biasi154 – 160Poly-Glu7

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 47C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 224C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri297 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129803.
HOGENOMiHOG000170898.
HOVERGENiHBG108772.
InParanoidiQ8IZM8.
OMAiTECGDDY.
OrthoDBiEOG091G0B4Q.
PhylomeDBiQ8IZM8.
TreeFamiTF326007.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCNKEFLGG HIVRHAQAHQ KKGSFACVIC GRKFRNRGLM QKHLKNHVKK
60 70 80 90 100
IQRQQIAAAQ QDDQEVTALE EINCSSSSIS FENGNSDSKD LEVETLTASS
110 120 130 140 150
EGNKEVIPEH VAEFIEIPIS VPEDVIENVI ENGSPNNSLN NVFKPLTECG
160 170 180 190 200
DDYEEEEDEE GDYEEDDYDL NQETSVIHKI NGTVCHPKDI YATDQEGNFK
210 220 230 240 250
CPALGCVRIF KRIGFLNKHA MTVHPTDLNV RQTVMKWSKG KCKFCQRQFE
260 270 280 290 300
DSQHFIDHLN RHSYPNVYFC LHFNCNESFK LPFQLAQHTK SHRIFQAQCS
310 320 330 340 350
FPECHELFED LPLLYEHEAQ HYLSKTPESS AQPSETILWD VQTDSNPNQE
360 370 380 390 400
KDSSSNEKQT ISLPVSTSKS RKESTEPKTC IESMEKKTDS LVQNGNERSD
410 420 430 440 450
DTVSNISLID QKMPDIEPNS ENNCSSSDIV NGHSEIEQTP LVSSDPALKI
460 470 480 490 500
DTNRIRTENG SILPSVVPQE HNTLPVSQAP SKPNLTSEHT SYGLILTKPY
510 520 530 540 550
VRPLPPSYLD ERYLSMPKRR KFLTDRVDAC SDQDNVYKKS VKRLRCGKCL
560 570 580
TTYCNAEALE AHLAQKKCQT LFGFDSDDES A
Length:581
Mass (Da):65,854
Last modified:May 18, 2010 - v3
Checksum:i8B1FE6C4B1A72A12
GO

Sequence cautioni

The sequence AAN40504 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA91946 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15007 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti258H → Q in BAA91946 (PubMed:14702039).Curated1
Sequence conflicti294I → T in AAN40504 (Ref. 1) Curated1
Sequence conflicti294I → T in BAA91946 (PubMed:14702039).Curated1
Sequence conflicti548K → E in BAB15007 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543494 mRNA. Translation: AAN40504.1. Different initiation.
AK001859 mRNA. Translation: BAA91946.1. Different initiation.
AK024795 mRNA. Translation: BAB15007.1. Different initiation.
AC119733 Genomic DNA. No translation available.
AC128650 Genomic DNA. No translation available.
CCDSiCCDS46874.1.
RefSeqiNP_060763.2. NM_018293.2.
UniGeneiHs.591650.
Hs.661116.

Genome annotation databases

EnsembliENST00000309495; ENSP00000312141; ENSG00000175105.
GeneIDi55279.
KEGGihsa:55279.
UCSCiuc003dqv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543494 mRNA. Translation: AAN40504.1. Different initiation.
AK001859 mRNA. Translation: BAA91946.1. Different initiation.
AK024795 mRNA. Translation: BAB15007.1. Different initiation.
AC119733 Genomic DNA. No translation available.
AC128650 Genomic DNA. No translation available.
CCDSiCCDS46874.1.
RefSeqiNP_060763.2. NM_018293.2.
UniGeneiHs.591650.
Hs.661116.

3D structure databases

ProteinModelPortaliQ8IZM8.
SMRiQ8IZM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312141.

PTM databases

iPTMnetiQ8IZM8.
PhosphoSitePlusiQ8IZM8.

Polymorphism and mutation databases

BioMutaiZNF654.
DMDMi296453064.

Proteomic databases

EPDiQ8IZM8.
MaxQBiQ8IZM8.
PaxDbiQ8IZM8.
PeptideAtlasiQ8IZM8.
PRIDEiQ8IZM8.

Protocols and materials databases

DNASUi55279.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309495; ENSP00000312141; ENSG00000175105.
GeneIDi55279.
KEGGihsa:55279.
UCSCiuc003dqv.4. human.

Organism-specific databases

CTDi55279.
DisGeNETi55279.
GeneCardsiZNF654.
HGNCiHGNC:25612. ZNF654.
HPAiHPA036172.
HPA036173.
neXtProtiNX_Q8IZM8.
OpenTargetsiENSG00000175105.
PharmGKBiPA134923001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129803.
HOGENOMiHOG000170898.
HOVERGENiHBG108772.
InParanoidiQ8IZM8.
OMAiTECGDDY.
OrthoDBiEOG091G0B4Q.
PhylomeDBiQ8IZM8.
TreeFamiTF326007.

Miscellaneous databases

GenomeRNAii55279.
PROiQ8IZM8.

Gene expression databases

BgeeiENSG00000175105.
CleanExiHS_ZNF654.
GenevisibleiQ8IZM8. HS.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN654_HUMAN
AccessioniPrimary (citable) accession number: Q8IZM8
Secondary accession number(s): Q9H791, Q9NV14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.