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Q8IZM6

- Q8IZM6_HUMAN

UniProt

Q8IZM6 - Q8IZM6_HUMAN

Protein
Submitted name:

BCH domain-containing Cdc42GAP-like protein

Gene

BPGAP1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GTPase activator activity Source: MGI

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. positive regulation of cell migration Source: MGI
    3. positive regulation of GTPase activity Source: GOC
    4. regulation of small GTPase mediated signal transduction Source: Reactome
    5. small GTPase mediated signal transduction Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    BCH domain-containing Cdc42GAP-like proteinImported
    Gene namesi
    Name:BPGAP1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8IZM6.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8IZM6. 1 interaction.
    MINTiMINT-1556875.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZM6.
    SMRiQ8IZM6. Positions 184-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG054433.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    3.40.525.10. 1 hit.
    InterProiIPR001251. CRAL-TRIO_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view]
    PfamiPF13716. CRAL_TRIO_2. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00324. RhoGAP. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF52087. SSF52087. 1 hit.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IZM6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGQDPALST SHPFYDVARH GILQVAGDDR FGRRVVTFSC CRMPPSHELD    50
    HQRLLEYLKY TLDQYVENDY TIVYFHYGLN SRNKPSLGWL QSAYKEFDRK 100
    YKKNLKALYV VHPTSFIKVL WNILKPLISH KFGKKVIYFN YLSELHEHLK 150
    YDQLVIPPEV LRYDEKLQSL HEGRTPPPTK TPPPRPPLPT QQFGVSLQYL 200
    KDKNQGELIP PVLRFTVTYL REKGLRTEGL FRRSASVQTV REIQRLYNQG 250
    KPVNFDDYGD IHIPAVILKT FLRELPQPLL TFQAYEQILG ITCVESSLRV 300
    TGCRQILRSL PEHNYVVLRY LMGSLHAVSR ESIFNKMNSS NLACVFGLNL 350
    IWPSQGVSSL SALVPLNMFT ELLIEYYEKI FSTPEAPGEH GLAPWEQGSR 400
    AAPLQEAVPR TQATGLTKPT LPPSPLMAAR RRL 433
    Length:433
    Mass (Da):49,691
    Last modified:March 1, 2003 - v1
    Checksum:i0AE4B42A404AE1D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF544240 mRNA. Translation: AAN40769.1.
    UniGeneiHs.102336.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF544240 mRNA. Translation: AAN40769.1 .
    UniGenei Hs.102336.

    3D structure databases

    ProteinModelPortali Q8IZM6.
    SMRi Q8IZM6. Positions 184-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8IZM6. 1 interaction.
    MINTi MINT-1556875.

    Proteomic databases

    PRIDEi Q8IZM6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG054433.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    ChiTaRSi ARHGAP8. human.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    3.40.525.10. 1 hit.
    InterProi IPR001251. CRAL-TRIO_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view ]
    Pfami PF13716. CRAL_TRIO_2. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00324. RhoGAP. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF52087. SSF52087. 1 hit.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1."
      Shang X., Zhou Y.T., Low B.C.
      J. Biol. Chem. 278:45903-45914(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ8IZM6_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZM6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.