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Q8IZM6

- Q8IZM6_HUMAN

UniProt

Q8IZM6 - Q8IZM6_HUMAN

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Protein
Submitted name: BCH domain-containing Cdc42GAP-like protein
Gene
BPGAP1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. GTPase activator activity Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. positive regulation of GTPase activity Source: GOC
  3. positive regulation of cell migration Source: MGI
  4. regulation of small GTPase mediated signal transduction Source: Reactome
  5. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Submitted name:
BCH domain-containing Cdc42GAP-like proteinImported
Gene namesi
Name:BPGAP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8IZM6.

Interactioni

Protein-protein interaction databases

IntActiQ8IZM6. 1 interaction.
MINTiMINT-1556875.

Structurei

3D structure databases

ProteinModelPortaliQ8IZM6.
SMRiQ8IZM6. Positions 184-381.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG054433.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZM6-1 [UniParc]FASTAAdd to Basket

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MAGQDPALST SHPFYDVARH GILQVAGDDR FGRRVVTFSC CRMPPSHELD    50
HQRLLEYLKY TLDQYVENDY TIVYFHYGLN SRNKPSLGWL QSAYKEFDRK 100
YKKNLKALYV VHPTSFIKVL WNILKPLISH KFGKKVIYFN YLSELHEHLK 150
YDQLVIPPEV LRYDEKLQSL HEGRTPPPTK TPPPRPPLPT QQFGVSLQYL 200
KDKNQGELIP PVLRFTVTYL REKGLRTEGL FRRSASVQTV REIQRLYNQG 250
KPVNFDDYGD IHIPAVILKT FLRELPQPLL TFQAYEQILG ITCVESSLRV 300
TGCRQILRSL PEHNYVVLRY LMGSLHAVSR ESIFNKMNSS NLACVFGLNL 350
IWPSQGVSSL SALVPLNMFT ELLIEYYEKI FSTPEAPGEH GLAPWEQGSR 400
AAPLQEAVPR TQATGLTKPT LPPSPLMAAR RRL 433
Length:433
Mass (Da):49,691
Last modified:March 1, 2003 - v1
Checksum:i0AE4B42A404AE1D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF544240 mRNA. Translation: AAN40769.1.
UniGeneiHs.102336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF544240 mRNA. Translation: AAN40769.1 .
UniGenei Hs.102336.

3D structure databases

ProteinModelPortali Q8IZM6.
SMRi Q8IZM6. Positions 184-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8IZM6. 1 interaction.
MINTi MINT-1556875.

Proteomic databases

PRIDEi Q8IZM6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG054433.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi ARHGAP8. human.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
3.40.525.10. 1 hit.
InterProi IPR001251. CRAL-TRIO_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view ]
Pfami PF13716. CRAL_TRIO_2. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1."
    Shang X., Zhou Y.T., Low B.C.
    J. Biol. Chem. 278:45903-45914(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8IZM6_HUMAN
AccessioniPrimary (citable) accession number: Q8IZM6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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