Q8IZM6 (Q8IZM6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
BCH domain-containing Cdc42GAP-like protein EMBL AAN40769.1

Gene names

Name:

BPGAP1 EMBL AAN40769.1

Organism

Homo sapiens (Human) EMBL AAN40769.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 CRAL-TRIO domain. SAAS SAAS001251

Ontologies

Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from direct assay Ref.1. Source: MGI positive regulation of cell migration Inferred from direct assay Ref.1. Source: MGI regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	GTPase activator activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IZM6 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 0AE4B42A404AE1D3	FASTA	433	49,691
	10 20 30 40 50 60 MAGQDPALST SHPFYDVARH GILQVAGDDR FGRRVVTFSC CRMPPSHELD HQRLLEYLKY 70 80 90 100 110 120 TLDQYVENDY TIVYFHYGLN SRNKPSLGWL QSAYKEFDRK YKKNLKALYV VHPTSFIKVL 130 140 150 160 170 180 WNILKPLISH KFGKKVIYFN YLSELHEHLK YDQLVIPPEV LRYDEKLQSL HEGRTPPPTK 190 200 210 220 230 240 TPPPRPPLPT QQFGVSLQYL KDKNQGELIP PVLRFTVTYL REKGLRTEGL FRRSASVQTV 250 260 270 280 290 300 REIQRLYNQG KPVNFDDYGD IHIPAVILKT FLRELPQPLL TFQAYEQILG ITCVESSLRV 310 320 330 340 350 360 TGCRQILRSL PEHNYVVLRY LMGSLHAVSR ESIFNKMNSS NLACVFGLNL IWPSQGVSSL 370 380 390 400 410 420 SALVPLNMFT ELLIEYYEKI FSTPEAPGEH GLAPWEQGSR AAPLQEAVPR TQATGLTKPT 430 LPPSPLMAAR RRL

References

[1]	"Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1." Shang X., Zhou Y.T., Low B.C. J. Biol. Chem. 278:45903-45914(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF544240 mRNA. Translation: AAN40769.1.
IPI	IPI00744264.
UniGene	Hs.102336.
3D structure databases
HSSP	HSSP built from PDB template 1RGP based on UniProtKB Q07960.
ProteinModelPortal	Q8IZM6.
SMR	Q8IZM6. Positions 184-381.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZM6. 1 interaction.
MINT	MINT-1556875.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG054433.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Family and domain databases
Gene3D	1.10.555.10. 1 hit. 3.40.525.10. 1 hit.
InterPro	IPR001251. CRAL-TRIO_dom. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Pfam	PF00620. RhoGAP. 1 hit. [Graphical view]
SMART	SM00324. RhoGAP. 1 hit. SM00516. SEC14. 1 hit. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50191. CRAL_TRIO. 1 hit. PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ARHGAP8. human.

Entry information

Entry name

Q8IZM6_HUMAN

Accession

Primary (citable) accession number: Q8IZM6

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.