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Protein
Submitted name:

BCH domain-containing Cdc42GAP-like protein

Gene

BPGAP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of GTPase activity Source: GOC
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Submitted name:
BCH domain-containing Cdc42GAP-like proteinImported
Gene namesi
Name:BPGAP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8IZM6.

Interactioni

Protein-protein interaction databases

IntActiQ8IZM6. 1 interaction.
MINTiMINT-1556875.
STRINGi9606.ENSP00000374423.

Structurei

3D structure databases

ProteinModelPortaliQ8IZM6.
SMRiQ8IZM6. Positions 184-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG054433.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IZM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQDPALST SHPFYDVARH GILQVAGDDR FGRRVVTFSC CRMPPSHELD
60 70 80 90 100
HQRLLEYLKY TLDQYVENDY TIVYFHYGLN SRNKPSLGWL QSAYKEFDRK
110 120 130 140 150
YKKNLKALYV VHPTSFIKVL WNILKPLISH KFGKKVIYFN YLSELHEHLK
160 170 180 190 200
YDQLVIPPEV LRYDEKLQSL HEGRTPPPTK TPPPRPPLPT QQFGVSLQYL
210 220 230 240 250
KDKNQGELIP PVLRFTVTYL REKGLRTEGL FRRSASVQTV REIQRLYNQG
260 270 280 290 300
KPVNFDDYGD IHIPAVILKT FLRELPQPLL TFQAYEQILG ITCVESSLRV
310 320 330 340 350
TGCRQILRSL PEHNYVVLRY LMGSLHAVSR ESIFNKMNSS NLACVFGLNL
360 370 380 390 400
IWPSQGVSSL SALVPLNMFT ELLIEYYEKI FSTPEAPGEH GLAPWEQGSR
410 420 430
AAPLQEAVPR TQATGLTKPT LPPSPLMAAR RRL
Length:433
Mass (Da):49,691
Last modified:March 1, 2003 - v1
Checksum:i0AE4B42A404AE1D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF544240 mRNA. Translation: AAN40769.1.
UniGeneiHs.102336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF544240 mRNA. Translation: AAN40769.1.
UniGeneiHs.102336.

3D structure databases

ProteinModelPortaliQ8IZM6.
SMRiQ8IZM6. Positions 184-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IZM6. 1 interaction.
MINTiMINT-1556875.
STRINGi9606.ENSP00000374423.

Proteomic databases

PRIDEiQ8IZM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG054433.

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiARHGAP8. human.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1."
    Shang X., Zhou Y.T., Low B.C.
    J. Biol. Chem. 278:45903-45914(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8IZM6_HUMAN
AccessioniPrimary (citable) accession number: Q8IZM6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.