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Protein

Cyclin-dependent kinase 20

Gene

CDK20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8IZL9.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 20 (EC:2.7.11.22)
Alternative name(s):
CDK-activating kinase p42
Short name:
CAK-kinase p42
Cell cycle-related kinase
Cell division protein kinase 20
Cyclin-dependent protein kinase H
Cyclin-kinase-activating kinase p42
Gene namesi
Name:CDK20
Synonyms:CCRK, CDCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21420. CDK20.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm By similarity. Cell projectioncilium By similarity

GO - Cellular componenti

  1. cilium Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi161 – 1611T → A: Impairs CDK2 T-160 phosphorylation and activity. 1 Publication

Organism-specific databases

PharmGKBiPA165585688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Cyclin-dependent kinase 20PRO_0000085701Add
BLAST

Proteomic databases

PaxDbiQ8IZL9.
PRIDEiQ8IZL9.

Expressioni

Gene expression databases

BgeeiQ8IZL9.
CleanExiHS_CCRK.
ExpressionAtlasiQ8IZL9. baseline and differential.
GenevestigatoriQ8IZL9.

Organism-specific databases

HPAiHPA007666.
HPA027379.
HPA027401.

Interactioni

Subunit structurei

Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK.By similarity2 Publications

Protein-protein interaction databases

BioGridi117096. 33 interactions.
IntActiQ8IZL9. 19 interactions.
STRINGi9606.ENSP00000322343.

Structurei

3D structure databases

ProteinModelPortaliQ8IZL9.
SMRiQ8IZL9. Positions 1-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 288285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ8IZL9.
KOiK08817.
OMAiAFTHGVP.
OrthoDBiEOG75J0NH.
PhylomeDBiQ8IZL9.
TreeFamiTF327240.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGFPNQALR
60 70 80 90 100
EIKALQEMED NQYVVQLKAV FPHGGGFVLA FEFMLSDLAE VVRHAQRPLA
110 120 130 140 150
QAQVKSYLQM LLKGVAFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR
160 170 180 190 200
VFSPDGSRLY THQVATRWYR APELLYGARQ YDQGVDLWSV GCIMGELLNG
210 220 230 240 250
SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI SFKEQVPMPL
260 270 280 290 300
EEVLPDVSPQ ALDLLGQFLL YPPHQRIAAS KALLHQYFFT APLPAHPSEL
310 320 330 340
PIPQRLGGPA PKAHPGPPHI HDFHVDRPLE ESLLNPELIR PFILEG
Length:346
Mass (Da):38,695
Last modified:February 28, 2003 - v1
Checksum:iEB6A53E97301D5AE
GO
Isoform 2 (identifier: Q8IZL9-2) [UniParc]FASTAAdd to basket

Also known as: Cardiac CCRK

The sequence of this isoform differs from the canonical sequence as follows:
     168-243: WYRAPELLYG...LPDYNKISFK → SSLSCRTTTR...IHLSCRFLSV
     244-346: Missing.

Show »
Length:243
Mass (Da):27,100
Checksum:iDA6A937563982609
GO
Isoform 3 (identifier: Q8IZL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-188: Missing.
     282-296: ALLHQYFFTAPLPAH → LPCLPIHLSCRFLSV
     297-346: Missing.

Note: No experimental confirmation available.

Show »
Length:275
Mass (Da):30,571
Checksum:i02CAB07F9B04C71C
GO
Isoform 4 (identifier: Q8IZL9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-25: E → EPRVGWQCLPSILQ
     168-188: Missing.

Note: No experimental confirmation available.

Show »
Length:338
Mass (Da):37,592
Checksum:i33F8C444B2AC77CC
GO
Isoform 5 (identifier: Q8IZL9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-188: Missing.

Note: No experimental confirmation available.

Show »
Length:325
Mass (Da):36,113
Checksum:iD3C6C46BF34C152C
GO

Sequence cautioni

The sequence AAC98920.1 differs from that shown. Reason: Frameshift at position 331. Curated
The sequence CAH72843.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301V → I in AAC98920 (Ref. 1) Curated
Sequence conflicti30 – 301V → I in AAF43778 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti86 – 861S → L.1 Publication
Corresponds to variant rs28364953 [ dbSNP | Ensembl ].
VAR_024762
Natural varianti106 – 1061S → N.1 Publication
Corresponds to variant rs41286029 [ dbSNP | Ensembl ].
VAR_041957
Natural varianti137 – 1371A → T.1 Publication
Corresponds to variant rs28364955 [ dbSNP | Ensembl ].
VAR_024763
Natural varianti281 – 2811K → R.1 Publication
Corresponds to variant rs28364963 [ dbSNP | Ensembl ].
VAR_024764

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 251E → EPRVGWQCLPSILQ in isoform 4. 1 PublicationVSP_043294
Alternative sequencei168 – 24376WYRAP…KISFK → SSLSCRTTTRSPLRSRCPCP WRRCCLTSLPRHWICWVNSF STLLTSASQLPRLSSISTSS QLPCLPIHLSCRFLSV in isoform 2. 2 PublicationsVSP_016748Add
BLAST
Alternative sequencei168 – 18821Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsVSP_016749Add
BLAST
Alternative sequencei244 – 346103Missing in isoform 2. 2 PublicationsVSP_016750Add
BLAST
Alternative sequencei282 – 29615ALLHQ…PLPAH → LPCLPIHLSCRFLSV in isoform 3. 1 PublicationVSP_016751Add
BLAST
Alternative sequencei297 – 34650Missing in isoform 3. 1 PublicationVSP_016752Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035013 mRNA. Translation: AAC98920.1. Frameshift.
AF113130 mRNA. Translation: AAF43778.1.
AY904367 mRNA. Translation: AAW82349.1.
AF547664 Genomic DNA. Translation: AAN28684.1.
AK075325 mRNA. Translation: BAG52110.1.
AK298993 mRNA. Translation: BAG61083.1.
AL353572 Genomic DNA. Translation: CAH72843.1. Sequence problems.
AL353572 Genomic DNA. Translation: CAM17657.1.
AL353572 Genomic DNA. Translation: CAM17658.1.
CH471089 Genomic DNA. Translation: EAW62746.1.
CH471089 Genomic DNA. Translation: EAW62748.1.
BC002655 mRNA. Translation: AAH02655.1.
CCDSiCCDS35060.1. [Q8IZL9-1]
CCDS55324.1. [Q8IZL9-2]
CCDS65075.1. [Q8IZL9-3]
CCDS6677.1. [Q8IZL9-5]
CCDS6678.1. [Q8IZL9-4]
RefSeqiNP_001034892.1. NM_001039803.2. [Q8IZL9-1]
NP_001164110.1. NM_001170639.1. [Q8IZL9-3]
NP_001164111.1. NM_001170640.1. [Q8IZL9-2]
NP_036251.2. NM_012119.4. [Q8IZL9-5]
NP_848519.1. NM_178432.3. [Q8IZL9-4]
UniGeneiHs.522274.

Genome annotation databases

EnsembliENST00000325303; ENSP00000322343; ENSG00000156345. [Q8IZL9-1]
ENST00000336654; ENSP00000338975; ENSG00000156345. [Q8IZL9-4]
ENST00000375871; ENSP00000365031; ENSG00000156345. [Q8IZL9-2]
ENST00000375883; ENSP00000365043; ENSG00000156345. [Q8IZL9-5]
ENST00000605159; ENSP00000474485; ENSG00000156345. [Q8IZL9-3]
GeneIDi23552.
KEGGihsa:23552.
UCSCiuc004apr.3. human. [Q8IZL9-1]
uc004apt.3. human. [Q8IZL9-4]
uc004apu.3. human. [Q8IZL9-2]
uc022bjj.1. human. [Q8IZL9-3]

Polymorphism databases

DMDMi74759739.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035013 mRNA. Translation: AAC98920.1. Frameshift.
AF113130 mRNA. Translation: AAF43778.1.
AY904367 mRNA. Translation: AAW82349.1.
AF547664 Genomic DNA. Translation: AAN28684.1.
AK075325 mRNA. Translation: BAG52110.1.
AK298993 mRNA. Translation: BAG61083.1.
AL353572 Genomic DNA. Translation: CAH72843.1. Sequence problems.
AL353572 Genomic DNA. Translation: CAM17657.1.
AL353572 Genomic DNA. Translation: CAM17658.1.
CH471089 Genomic DNA. Translation: EAW62746.1.
CH471089 Genomic DNA. Translation: EAW62748.1.
BC002655 mRNA. Translation: AAH02655.1.
CCDSiCCDS35060.1. [Q8IZL9-1]
CCDS55324.1. [Q8IZL9-2]
CCDS65075.1. [Q8IZL9-3]
CCDS6677.1. [Q8IZL9-5]
CCDS6678.1. [Q8IZL9-4]
RefSeqiNP_001034892.1. NM_001039803.2. [Q8IZL9-1]
NP_001164110.1. NM_001170639.1. [Q8IZL9-3]
NP_001164111.1. NM_001170640.1. [Q8IZL9-2]
NP_036251.2. NM_012119.4. [Q8IZL9-5]
NP_848519.1. NM_178432.3. [Q8IZL9-4]
UniGeneiHs.522274.

3D structure databases

ProteinModelPortaliQ8IZL9.
SMRiQ8IZL9. Positions 1-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117096. 33 interactions.
IntActiQ8IZL9. 19 interactions.
STRINGi9606.ENSP00000322343.

Polymorphism databases

DMDMi74759739.

Proteomic databases

PaxDbiQ8IZL9.
PRIDEiQ8IZL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325303; ENSP00000322343; ENSG00000156345. [Q8IZL9-1]
ENST00000336654; ENSP00000338975; ENSG00000156345. [Q8IZL9-4]
ENST00000375871; ENSP00000365031; ENSG00000156345. [Q8IZL9-2]
ENST00000375883; ENSP00000365043; ENSG00000156345. [Q8IZL9-5]
ENST00000605159; ENSP00000474485; ENSG00000156345. [Q8IZL9-3]
GeneIDi23552.
KEGGihsa:23552.
UCSCiuc004apr.3. human. [Q8IZL9-1]
uc004apt.3. human. [Q8IZL9-4]
uc004apu.3. human. [Q8IZL9-2]
uc022bjj.1. human. [Q8IZL9-3]

Organism-specific databases

CTDi23552.
GeneCardsiGC09M090582.
HGNCiHGNC:21420. CDK20.
HPAiHPA007666.
HPA027379.
HPA027401.
MIMi610076. gene.
neXtProtiNX_Q8IZL9.
PharmGKBiPA165585688.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ8IZL9.
KOiK08817.
OMAiAFTHGVP.
OrthoDBiEOG75J0NH.
PhylomeDBiQ8IZL9.
TreeFamiTF327240.

Enzyme and pathway databases

SignaLinkiQ8IZL9.

Miscellaneous databases

ChiTaRSiCDK20. human.
GenomeRNAii23552.
NextBioi13603278.
PROiQ8IZL9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZL9.
CleanExiHS_CCRK.
ExpressionAtlasiQ8IZL9. baseline and differential.
GenevestigatoriQ8IZL9.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Jiang Y., Zhao K.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
  2. "Cloning a cyclin-dependent protein kinase CDCH."
    Chen J.H., Luo W.Q., Hu S.N., Huang X.W., Tan X.Y., Yuan J.G., Qiang B.Q.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
  3. "Cardiac CCRK splice variant."
    Qiu H., Depre C.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Heart.
  4. NIEHS SNPs program
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-86; THR-137 AND ARG-281.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
  6. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Uterus.
  9. "p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells."
    Liu Y., Wu C., Galaktionov K.
    J. Biol. Chem. 279:4507-4514(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-161.
  10. "Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1)."
    Wang L.Y., Kung H.J.
    Oncogene 31:2907-2918(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAK.
  11. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-106.

Entry informationi

Entry nameiCDK20_HUMAN
AccessioniPrimary (citable) accession number: Q8IZL9
Secondary accession number(s): A2A389
, A2A390, B4DQX1, O95137, Q5EDC4, Q5VYW1, Q9BUF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2005
Last sequence update: February 28, 2003
Last modified: January 6, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.