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Protein

Cyclin-dependent kinase 20

Gene

CDK20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei127Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8IZL9
SIGNORiQ8IZL9

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 20 (EC:2.7.11.22)
Alternative name(s):
CDK-activating kinase p42
Short name:
CAK-kinase p42
Cell cycle-related kinase
Cell division protein kinase 20
Cyclin-dependent protein kinase H
Cyclin-kinase-activating kinase p42
Gene namesi
Name:CDK20
Synonyms:CCRK, CDCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000156345.17
HGNCiHGNC:21420 CDK20
MIMi610076 gene
neXtProtiNX_Q8IZL9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi161T → A: Impairs CDK2 T-160 phosphorylation and activity. 1 Publication1

Organism-specific databases

DisGeNETi23552
MalaCardsiCDK20
OpenTargetsiENSG00000156345
PharmGKBiPA165585688

Chemistry databases

ChEMBLiCHEMBL3559691

Polymorphism and mutation databases

BioMutaiCDK20
DMDMi74759739

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857011 – 346Cyclin-dependent kinase 20Add BLAST346

Proteomic databases

MaxQBiQ8IZL9
PaxDbiQ8IZL9
PeptideAtlasiQ8IZL9
PRIDEiQ8IZL9

PTM databases

iPTMnetiQ8IZL9
PhosphoSitePlusiQ8IZL9

Expressioni

Gene expression databases

BgeeiENSG00000156345
CleanExiHS_CCRK
ExpressionAtlasiQ8IZL9 baseline and differential
GenevisibleiQ8IZL9 HS

Organism-specific databases

HPAiHPA007666
HPA027379
HPA027401

Interactioni

Subunit structurei

Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM2Q9C0403EBI-6128565,EBI-749840

Protein-protein interaction databases

BioGridi117096, 45 interactors
IntActiQ8IZL9, 21 interactors
STRINGi9606.ENSP00000322343

Structurei

3D structure databases

ProteinModelPortaliQ8IZL9
SMRiQ8IZL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 288Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0659 Eukaryota
ENOG410XQDH LUCA
GeneTreeiENSGT00830000128262
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ8IZL9
KOiK08817
OMAiLWGSQKY
OrthoDBiEOG091G0CI9
PhylomeDBiQ8IZL9
TreeFamiTF327240

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGFPNQALR
60 70 80 90 100
EIKALQEMED NQYVVQLKAV FPHGGGFVLA FEFMLSDLAE VVRHAQRPLA
110 120 130 140 150
QAQVKSYLQM LLKGVAFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR
160 170 180 190 200
VFSPDGSRLY THQVATRWYR APELLYGARQ YDQGVDLWSV GCIMGELLNG
210 220 230 240 250
SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI SFKEQVPMPL
260 270 280 290 300
EEVLPDVSPQ ALDLLGQFLL YPPHQRIAAS KALLHQYFFT APLPAHPSEL
310 320 330 340
PIPQRLGGPA PKAHPGPPHI HDFHVDRPLE ESLLNPELIR PFILEG
Length:346
Mass (Da):38,695
Last modified:March 1, 2003 - v1
Checksum:iEB6A53E97301D5AE
GO
Isoform 2 (identifier: Q8IZL9-2) [UniParc]FASTAAdd to basket
Also known as: Cardiac CCRK

The sequence of this isoform differs from the canonical sequence as follows:
     168-243: WYRAPELLYG...LPDYNKISFK → SSLSCRTTTR...IHLSCRFLSV
     244-346: Missing.

Show »
Length:243
Mass (Da):27,100
Checksum:iDA6A937563982609
GO
Isoform 3 (identifier: Q8IZL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-188: Missing.
     282-296: ALLHQYFFTAPLPAH → LPCLPIHLSCRFLSV
     297-346: Missing.

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):30,571
Checksum:i02CAB07F9B04C71C
GO
Isoform 4 (identifier: Q8IZL9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-25: E → EPRVGWQCLPSILQ
     168-188: Missing.

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):37,592
Checksum:i33F8C444B2AC77CC
GO
Isoform 5 (identifier: Q8IZL9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-188: Missing.

Note: No experimental confirmation available.
Show »
Length:325
Mass (Da):36,113
Checksum:iD3C6C46BF34C152C
GO

Sequence cautioni

The sequence AAC98920 differs from that shown. Reason: Frameshift at position 331.Curated
The sequence CAH72843 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30V → I in AAC98920 (Ref. 1) Curated1
Sequence conflicti30V → I in AAF43778 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02476286S → L1 PublicationCorresponds to variant dbSNP:rs28364953Ensembl.1
Natural variantiVAR_041957106S → N1 PublicationCorresponds to variant dbSNP:rs41286029Ensembl.1
Natural variantiVAR_024763137A → T1 PublicationCorresponds to variant dbSNP:rs28364955Ensembl.1
Natural variantiVAR_024764281K → R1 PublicationCorresponds to variant dbSNP:rs28364963Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04329425E → EPRVGWQCLPSILQ in isoform 4. 1 Publication1
Alternative sequenceiVSP_016748168 – 243WYRAP…KISFK → SSLSCRTTTRSPLRSRCPCP WRRCCLTSLPRHWICWVNSF STLLTSASQLPRLSSISTSS QLPCLPIHLSCRFLSV in isoform 2. 2 PublicationsAdd BLAST76
Alternative sequenceiVSP_016749168 – 188Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST21
Alternative sequenceiVSP_016750244 – 346Missing in isoform 2. 2 PublicationsAdd BLAST103
Alternative sequenceiVSP_016751282 – 296ALLHQ…PLPAH → LPCLPIHLSCRFLSV in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_016752297 – 346Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035013 mRNA Translation: AAC98920.1 Frameshift.
AF113130 mRNA Translation: AAF43778.1
AY904367 mRNA Translation: AAW82349.1
AF547664 Genomic DNA Translation: AAN28684.1
AK075325 mRNA Translation: BAG52110.1
AK298993 mRNA Translation: BAG61083.1
AL353572 Genomic DNA Translation: CAH72843.1 Sequence problems.
AL353572 Genomic DNA Translation: CAM17657.1
AL353572 Genomic DNA Translation: CAM17658.1
CH471089 Genomic DNA Translation: EAW62746.1
CH471089 Genomic DNA Translation: EAW62748.1
BC002655 mRNA Translation: AAH02655.1
CCDSiCCDS35060.1 [Q8IZL9-1]
CCDS55324.1 [Q8IZL9-2]
CCDS65075.1 [Q8IZL9-3]
CCDS6677.1 [Q8IZL9-5]
CCDS6678.1 [Q8IZL9-4]
RefSeqiNP_001034892.1, NM_001039803.2 [Q8IZL9-1]
NP_001164110.1, NM_001170639.1 [Q8IZL9-3]
NP_001164111.1, NM_001170640.1 [Q8IZL9-2]
NP_036251.2, NM_012119.4 [Q8IZL9-5]
NP_848519.1, NM_178432.3 [Q8IZL9-4]
UniGeneiHs.522274

Genome annotation databases

EnsembliENST00000325303; ENSP00000322343; ENSG00000156345 [Q8IZL9-1]
ENST00000336654; ENSP00000338975; ENSG00000156345 [Q8IZL9-4]
ENST00000375871; ENSP00000365031; ENSG00000156345 [Q8IZL9-2]
ENST00000375883; ENSP00000365043; ENSG00000156345 [Q8IZL9-5]
ENST00000605159; ENSP00000474485; ENSG00000156345 [Q8IZL9-3]
GeneIDi23552
KEGGihsa:23552
UCSCiuc004apr.4 human [Q8IZL9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCDK20_HUMAN
AccessioniPrimary (citable) accession number: Q8IZL9
Secondary accession number(s): A2A389
, A2A390, B4DQX1, O95137, Q5EDC4, Q5VYW1, Q9BUF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

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