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Q8IZL9

- CDK20_HUMAN

UniProt

Q8IZL9 - CDK20_HUMAN

Protein

Cyclin-dependent kinase 20

Gene

CDK20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling By similarity. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.By similarity1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8IZL9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 20 (EC:2.7.11.22)
    Alternative name(s):
    CDK-activating kinase p42
    Short name:
    CAK-kinase p42
    Cell cycle-related kinase
    Cell division protein kinase 20
    Cyclin-dependent protein kinase H
    Cyclin-kinase-activating kinase p42
    Gene namesi
    Name:CDK20
    Synonyms:CCRK, CDCH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:21420. CDK20.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm By similarity. Cell projectioncilium By similarity

    GO - Cellular componenti

    1. cilium Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi161 – 1611T → A: Impairs CDK2 T-160 phosphorylation and activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA165585688.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Cyclin-dependent kinase 20PRO_0000085701Add
    BLAST

    Proteomic databases

    PaxDbiQ8IZL9.
    PRIDEiQ8IZL9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IZL9.
    BgeeiQ8IZL9.
    CleanExiHS_CCRK.
    GenevestigatoriQ8IZL9.

    Organism-specific databases

    HPAiHPA007666.
    HPA027379.
    HPA027401.

    Interactioni

    Subunit structurei

    Monomer. Interacts with TBC1D32 By similarity. Interacts with MAK.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi117096. 31 interactions.
    IntActiQ8IZL9. 19 interactions.
    STRINGi9606.ENSP00000322343.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZL9.
    SMRiQ8IZL9. Positions 1-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 288285Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    KOiK08817.
    OMAiRPFIPEG.
    OrthoDBiEOG75J0NH.
    PhylomeDBiQ8IZL9.
    TreeFamiTF327240.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IZL9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGFPNQALR    50
    EIKALQEMED NQYVVQLKAV FPHGGGFVLA FEFMLSDLAE VVRHAQRPLA 100
    QAQVKSYLQM LLKGVAFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR 150
    VFSPDGSRLY THQVATRWYR APELLYGARQ YDQGVDLWSV GCIMGELLNG 200
    SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI SFKEQVPMPL 250
    EEVLPDVSPQ ALDLLGQFLL YPPHQRIAAS KALLHQYFFT APLPAHPSEL 300
    PIPQRLGGPA PKAHPGPPHI HDFHVDRPLE ESLLNPELIR PFILEG 346
    Length:346
    Mass (Da):38,695
    Last modified:March 1, 2003 - v1
    Checksum:iEB6A53E97301D5AE
    GO
    Isoform 2 (identifier: Q8IZL9-2) [UniParc]FASTAAdd to Basket

    Also known as: Cardiac CCRK

    The sequence of this isoform differs from the canonical sequence as follows:
         168-243: WYRAPELLYG...LPDYNKISFK → SSLSCRTTTR...IHLSCRFLSV
         244-346: Missing.

    Show »
    Length:243
    Mass (Da):27,100
    Checksum:iDA6A937563982609
    GO
    Isoform 3 (identifier: Q8IZL9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         168-188: Missing.
         282-296: ALLHQYFFTAPLPAH → LPCLPIHLSCRFLSV
         297-346: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:275
    Mass (Da):30,571
    Checksum:i02CAB07F9B04C71C
    GO
    Isoform 4 (identifier: Q8IZL9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         25-25: E → EPRVGWQCLPSILQ
         168-188: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:338
    Mass (Da):37,592
    Checksum:i33F8C444B2AC77CC
    GO
    Isoform 5 (identifier: Q8IZL9-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         168-188: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:325
    Mass (Da):36,113
    Checksum:iD3C6C46BF34C152C
    GO

    Sequence cautioni

    The sequence AAC98920.1 differs from that shown. Reason: Frameshift at position 331.
    The sequence CAH72843.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301V → I in AAC98920. 1 PublicationCurated
    Sequence conflicti30 – 301V → I in AAF43778. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti86 – 861S → L.1 Publication
    Corresponds to variant rs28364953 [ dbSNP | Ensembl ].
    VAR_024762
    Natural varianti106 – 1061S → N.1 Publication
    Corresponds to variant rs41286029 [ dbSNP | Ensembl ].
    VAR_041957
    Natural varianti137 – 1371A → T.1 Publication
    Corresponds to variant rs28364955 [ dbSNP | Ensembl ].
    VAR_024763
    Natural varianti281 – 2811K → R.1 Publication
    Corresponds to variant rs28364963 [ dbSNP | Ensembl ].
    VAR_024764

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei25 – 251E → EPRVGWQCLPSILQ in isoform 4. 1 PublicationVSP_043294
    Alternative sequencei168 – 24376WYRAP…KISFK → SSLSCRTTTRSPLRSRCPCP WRRCCLTSLPRHWICWVNSF STLLTSASQLPRLSSISTSS QLPCLPIHLSCRFLSV in isoform 2. 2 PublicationsVSP_016748Add
    BLAST
    Alternative sequencei168 – 18821Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsVSP_016749Add
    BLAST
    Alternative sequencei244 – 346103Missing in isoform 2. 2 PublicationsVSP_016750Add
    BLAST
    Alternative sequencei282 – 29615ALLHQ…PLPAH → LPCLPIHLSCRFLSV in isoform 3. 1 PublicationVSP_016751Add
    BLAST
    Alternative sequencei297 – 34650Missing in isoform 3. 1 PublicationVSP_016752Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035013 mRNA. Translation: AAC98920.1. Frameshift.
    AF113130 mRNA. Translation: AAF43778.1.
    AY904367 mRNA. Translation: AAW82349.1.
    AF547664 Genomic DNA. Translation: AAN28684.1.
    AK075325 mRNA. Translation: BAG52110.1.
    AK298993 mRNA. Translation: BAG61083.1.
    AL353572 Genomic DNA. Translation: CAH72843.1. Sequence problems.
    AL353572 Genomic DNA. Translation: CAM17657.1.
    AL353572 Genomic DNA. Translation: CAM17658.1.
    CH471089 Genomic DNA. Translation: EAW62746.1.
    CH471089 Genomic DNA. Translation: EAW62748.1.
    BC002655 mRNA. Translation: AAH02655.1.
    CCDSiCCDS35060.1. [Q8IZL9-1]
    CCDS55324.1. [Q8IZL9-2]
    CCDS65075.1. [Q8IZL9-3]
    CCDS6677.1. [Q8IZL9-5]
    CCDS6678.1. [Q8IZL9-4]
    RefSeqiNP_001034892.1. NM_001039803.2. [Q8IZL9-1]
    NP_001164110.1. NM_001170639.1. [Q8IZL9-3]
    NP_001164111.1. NM_001170640.1. [Q8IZL9-2]
    NP_036251.2. NM_012119.4. [Q8IZL9-5]
    NP_848519.1. NM_178432.3. [Q8IZL9-4]
    UniGeneiHs.522274.

    Genome annotation databases

    EnsembliENST00000325303; ENSP00000322343; ENSG00000156345. [Q8IZL9-1]
    ENST00000336654; ENSP00000338975; ENSG00000156345. [Q8IZL9-4]
    ENST00000375871; ENSP00000365031; ENSG00000156345. [Q8IZL9-2]
    ENST00000375883; ENSP00000365043; ENSG00000156345. [Q8IZL9-5]
    ENST00000605159; ENSP00000474485; ENSG00000156345. [Q8IZL9-3]
    GeneIDi23552.
    KEGGihsa:23552.
    UCSCiuc004apr.3. human. [Q8IZL9-1]
    uc004apt.3. human. [Q8IZL9-4]
    uc004apu.3. human. [Q8IZL9-2]
    uc022bjj.1. human. [Q8IZL9-3]

    Polymorphism databases

    DMDMi74759739.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035013 mRNA. Translation: AAC98920.1 . Frameshift.
    AF113130 mRNA. Translation: AAF43778.1 .
    AY904367 mRNA. Translation: AAW82349.1 .
    AF547664 Genomic DNA. Translation: AAN28684.1 .
    AK075325 mRNA. Translation: BAG52110.1 .
    AK298993 mRNA. Translation: BAG61083.1 .
    AL353572 Genomic DNA. Translation: CAH72843.1 . Sequence problems.
    AL353572 Genomic DNA. Translation: CAM17657.1 .
    AL353572 Genomic DNA. Translation: CAM17658.1 .
    CH471089 Genomic DNA. Translation: EAW62746.1 .
    CH471089 Genomic DNA. Translation: EAW62748.1 .
    BC002655 mRNA. Translation: AAH02655.1 .
    CCDSi CCDS35060.1. [Q8IZL9-1 ]
    CCDS55324.1. [Q8IZL9-2 ]
    CCDS65075.1. [Q8IZL9-3 ]
    CCDS6677.1. [Q8IZL9-5 ]
    CCDS6678.1. [Q8IZL9-4 ]
    RefSeqi NP_001034892.1. NM_001039803.2. [Q8IZL9-1 ]
    NP_001164110.1. NM_001170639.1. [Q8IZL9-3 ]
    NP_001164111.1. NM_001170640.1. [Q8IZL9-2 ]
    NP_036251.2. NM_012119.4. [Q8IZL9-5 ]
    NP_848519.1. NM_178432.3. [Q8IZL9-4 ]
    UniGenei Hs.522274.

    3D structure databases

    ProteinModelPortali Q8IZL9.
    SMRi Q8IZL9. Positions 1-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117096. 31 interactions.
    IntActi Q8IZL9. 19 interactions.
    STRINGi 9606.ENSP00000322343.

    Polymorphism databases

    DMDMi 74759739.

    Proteomic databases

    PaxDbi Q8IZL9.
    PRIDEi Q8IZL9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325303 ; ENSP00000322343 ; ENSG00000156345 . [Q8IZL9-1 ]
    ENST00000336654 ; ENSP00000338975 ; ENSG00000156345 . [Q8IZL9-4 ]
    ENST00000375871 ; ENSP00000365031 ; ENSG00000156345 . [Q8IZL9-2 ]
    ENST00000375883 ; ENSP00000365043 ; ENSG00000156345 . [Q8IZL9-5 ]
    ENST00000605159 ; ENSP00000474485 ; ENSG00000156345 . [Q8IZL9-3 ]
    GeneIDi 23552.
    KEGGi hsa:23552.
    UCSCi uc004apr.3. human. [Q8IZL9-1 ]
    uc004apt.3. human. [Q8IZL9-4 ]
    uc004apu.3. human. [Q8IZL9-2 ]
    uc022bjj.1. human. [Q8IZL9-3 ]

    Organism-specific databases

    CTDi 23552.
    GeneCardsi GC09M090582.
    HGNCi HGNC:21420. CDK20.
    HPAi HPA007666.
    HPA027379.
    HPA027401.
    MIMi 610076. gene.
    neXtProti NX_Q8IZL9.
    PharmGKBi PA165585688.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    KOi K08817.
    OMAi RPFIPEG.
    OrthoDBi EOG75J0NH.
    PhylomeDBi Q8IZL9.
    TreeFami TF327240.

    Enzyme and pathway databases

    SignaLinki Q8IZL9.

    Miscellaneous databases

    ChiTaRSi CDK20. human.
    GenomeRNAii 23552.
    NextBioi 13603278.
    PROi Q8IZL9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZL9.
    Bgeei Q8IZL9.
    CleanExi HS_CCRK.
    Genevestigatori Q8IZL9.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jiang Y., Zhao K.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    2. "Cloning a cyclin-dependent protein kinase CDCH."
      Chen J.H., Luo W.Q., Hu S.N., Huang X.W., Tan X.Y., Yuan J.G., Qiang B.Q.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    3. "Cardiac CCRK splice variant."
      Qiu H., Depre C.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Heart.
    4. NIEHS SNPs program
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-86; THR-137 AND ARG-281.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    6. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Uterus.
    9. "p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells."
      Liu Y., Wu C., Galaktionov K.
      J. Biol. Chem. 279:4507-4514(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-161.
    10. "Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1)."
      Wang L.Y., Kung H.J.
      Oncogene 31:2907-2918(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAK.
    11. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-106.

    Entry informationi

    Entry nameiCDK20_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZL9
    Secondary accession number(s): A2A389
    , A2A390, B4DQX1, O95137, Q5EDC4, Q5VYW1, Q9BUF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3