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Protein

Cyclin-dependent kinase 20

Gene

CDK20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei127Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08120-MONOMER.
SignaLinkiQ8IZL9.
SIGNORiQ8IZL9.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 20 (EC:2.7.11.22)
Alternative name(s):
CDK-activating kinase p42
Short name:
CAK-kinase p42
Cell cycle-related kinase
Cell division protein kinase 20
Cyclin-dependent protein kinase H
Cyclin-kinase-activating kinase p42
Gene namesi
Name:CDK20
Synonyms:CCRK, CDCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21420. CDK20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi161T → A: Impairs CDK2 T-160 phosphorylation and activity. 1 Publication1

Organism-specific databases

DisGeNETi23552.
OpenTargetsiENSG00000156345.
PharmGKBiPA165585688.

Chemistry databases

ChEMBLiCHEMBL3559691.

Polymorphism and mutation databases

BioMutaiCDK20.
DMDMi74759739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857011 – 346Cyclin-dependent kinase 20Add BLAST346

Proteomic databases

MaxQBiQ8IZL9.
PaxDbiQ8IZL9.
PeptideAtlasiQ8IZL9.
PRIDEiQ8IZL9.

PTM databases

iPTMnetiQ8IZL9.
PhosphoSitePlusiQ8IZL9.

Expressioni

Gene expression databases

BgeeiENSG00000156345.
CleanExiHS_CCRK.
ExpressionAtlasiQ8IZL9. baseline and differential.
GenevisibleiQ8IZL9. HS.

Organism-specific databases

HPAiHPA007666.
HPA027379.
HPA027401.

Interactioni

Subunit structurei

Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK.By similarity2 Publications

Protein-protein interaction databases

BioGridi117096. 35 interactors.
IntActiQ8IZL9. 20 interactors.
STRINGi9606.ENSP00000322343.

Structurei

3D structure databases

ProteinModelPortaliQ8IZL9.
SMRiQ8IZL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 288Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0659. Eukaryota.
ENOG410XQDH. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ8IZL9.
KOiK08817.
OMAiKAKHIET.
OrthoDBiEOG091G0CI9.
PhylomeDBiQ8IZL9.
TreeFamiTF327240.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGFPNQALR
60 70 80 90 100
EIKALQEMED NQYVVQLKAV FPHGGGFVLA FEFMLSDLAE VVRHAQRPLA
110 120 130 140 150
QAQVKSYLQM LLKGVAFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR
160 170 180 190 200
VFSPDGSRLY THQVATRWYR APELLYGARQ YDQGVDLWSV GCIMGELLNG
210 220 230 240 250
SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI SFKEQVPMPL
260 270 280 290 300
EEVLPDVSPQ ALDLLGQFLL YPPHQRIAAS KALLHQYFFT APLPAHPSEL
310 320 330 340
PIPQRLGGPA PKAHPGPPHI HDFHVDRPLE ESLLNPELIR PFILEG
Length:346
Mass (Da):38,695
Last modified:March 1, 2003 - v1
Checksum:iEB6A53E97301D5AE
GO
Isoform 2 (identifier: Q8IZL9-2) [UniParc]FASTAAdd to basket
Also known as: Cardiac CCRK

The sequence of this isoform differs from the canonical sequence as follows:
     168-243: WYRAPELLYG...LPDYNKISFK → SSLSCRTTTR...IHLSCRFLSV
     244-346: Missing.

Show »
Length:243
Mass (Da):27,100
Checksum:iDA6A937563982609
GO
Isoform 3 (identifier: Q8IZL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-188: Missing.
     282-296: ALLHQYFFTAPLPAH → LPCLPIHLSCRFLSV
     297-346: Missing.

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):30,571
Checksum:i02CAB07F9B04C71C
GO
Isoform 4 (identifier: Q8IZL9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-25: E → EPRVGWQCLPSILQ
     168-188: Missing.

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):37,592
Checksum:i33F8C444B2AC77CC
GO
Isoform 5 (identifier: Q8IZL9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-188: Missing.

Note: No experimental confirmation available.
Show »
Length:325
Mass (Da):36,113
Checksum:iD3C6C46BF34C152C
GO

Sequence cautioni

The sequence AAC98920 differs from that shown. Reason: Frameshift at position 331.Curated
The sequence CAH72843 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30V → I in AAC98920 (Ref. 1) Curated1
Sequence conflicti30V → I in AAF43778 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02476286S → L.1 PublicationCorresponds to variant rs28364953dbSNPEnsembl.1
Natural variantiVAR_041957106S → N.1 PublicationCorresponds to variant rs41286029dbSNPEnsembl.1
Natural variantiVAR_024763137A → T.1 PublicationCorresponds to variant rs28364955dbSNPEnsembl.1
Natural variantiVAR_024764281K → R.1 PublicationCorresponds to variant rs28364963dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04329425E → EPRVGWQCLPSILQ in isoform 4. 1 Publication1
Alternative sequenceiVSP_016748168 – 243WYRAP…KISFK → SSLSCRTTTRSPLRSRCPCP WRRCCLTSLPRHWICWVNSF STLLTSASQLPRLSSISTSS QLPCLPIHLSCRFLSV in isoform 2. 2 PublicationsAdd BLAST76
Alternative sequenceiVSP_016749168 – 188Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST21
Alternative sequenceiVSP_016750244 – 346Missing in isoform 2. 2 PublicationsAdd BLAST103
Alternative sequenceiVSP_016751282 – 296ALLHQ…PLPAH → LPCLPIHLSCRFLSV in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_016752297 – 346Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035013 mRNA. Translation: AAC98920.1. Frameshift.
AF113130 mRNA. Translation: AAF43778.1.
AY904367 mRNA. Translation: AAW82349.1.
AF547664 Genomic DNA. Translation: AAN28684.1.
AK075325 mRNA. Translation: BAG52110.1.
AK298993 mRNA. Translation: BAG61083.1.
AL353572 Genomic DNA. Translation: CAH72843.1. Sequence problems.
AL353572 Genomic DNA. Translation: CAM17657.1.
AL353572 Genomic DNA. Translation: CAM17658.1.
CH471089 Genomic DNA. Translation: EAW62746.1.
CH471089 Genomic DNA. Translation: EAW62748.1.
BC002655 mRNA. Translation: AAH02655.1.
CCDSiCCDS35060.1. [Q8IZL9-1]
CCDS55324.1. [Q8IZL9-2]
CCDS65075.1. [Q8IZL9-3]
CCDS6677.1. [Q8IZL9-5]
CCDS6678.1. [Q8IZL9-4]
RefSeqiNP_001034892.1. NM_001039803.2. [Q8IZL9-1]
NP_001164110.1. NM_001170639.1. [Q8IZL9-3]
NP_001164111.1. NM_001170640.1. [Q8IZL9-2]
NP_036251.2. NM_012119.4. [Q8IZL9-5]
NP_848519.1. NM_178432.3. [Q8IZL9-4]
UniGeneiHs.522274.

Genome annotation databases

EnsembliENST00000325303; ENSP00000322343; ENSG00000156345. [Q8IZL9-1]
ENST00000336654; ENSP00000338975; ENSG00000156345. [Q8IZL9-4]
ENST00000375871; ENSP00000365031; ENSG00000156345. [Q8IZL9-2]
ENST00000375883; ENSP00000365043; ENSG00000156345. [Q8IZL9-5]
ENST00000605159; ENSP00000474485; ENSG00000156345. [Q8IZL9-3]
GeneIDi23552.
KEGGihsa:23552.
UCSCiuc004apr.4. human. [Q8IZL9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035013 mRNA. Translation: AAC98920.1. Frameshift.
AF113130 mRNA. Translation: AAF43778.1.
AY904367 mRNA. Translation: AAW82349.1.
AF547664 Genomic DNA. Translation: AAN28684.1.
AK075325 mRNA. Translation: BAG52110.1.
AK298993 mRNA. Translation: BAG61083.1.
AL353572 Genomic DNA. Translation: CAH72843.1. Sequence problems.
AL353572 Genomic DNA. Translation: CAM17657.1.
AL353572 Genomic DNA. Translation: CAM17658.1.
CH471089 Genomic DNA. Translation: EAW62746.1.
CH471089 Genomic DNA. Translation: EAW62748.1.
BC002655 mRNA. Translation: AAH02655.1.
CCDSiCCDS35060.1. [Q8IZL9-1]
CCDS55324.1. [Q8IZL9-2]
CCDS65075.1. [Q8IZL9-3]
CCDS6677.1. [Q8IZL9-5]
CCDS6678.1. [Q8IZL9-4]
RefSeqiNP_001034892.1. NM_001039803.2. [Q8IZL9-1]
NP_001164110.1. NM_001170639.1. [Q8IZL9-3]
NP_001164111.1. NM_001170640.1. [Q8IZL9-2]
NP_036251.2. NM_012119.4. [Q8IZL9-5]
NP_848519.1. NM_178432.3. [Q8IZL9-4]
UniGeneiHs.522274.

3D structure databases

ProteinModelPortaliQ8IZL9.
SMRiQ8IZL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117096. 35 interactors.
IntActiQ8IZL9. 20 interactors.
STRINGi9606.ENSP00000322343.

Chemistry databases

ChEMBLiCHEMBL3559691.

PTM databases

iPTMnetiQ8IZL9.
PhosphoSitePlusiQ8IZL9.

Polymorphism and mutation databases

BioMutaiCDK20.
DMDMi74759739.

Proteomic databases

MaxQBiQ8IZL9.
PaxDbiQ8IZL9.
PeptideAtlasiQ8IZL9.
PRIDEiQ8IZL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325303; ENSP00000322343; ENSG00000156345. [Q8IZL9-1]
ENST00000336654; ENSP00000338975; ENSG00000156345. [Q8IZL9-4]
ENST00000375871; ENSP00000365031; ENSG00000156345. [Q8IZL9-2]
ENST00000375883; ENSP00000365043; ENSG00000156345. [Q8IZL9-5]
ENST00000605159; ENSP00000474485; ENSG00000156345. [Q8IZL9-3]
GeneIDi23552.
KEGGihsa:23552.
UCSCiuc004apr.4. human. [Q8IZL9-1]

Organism-specific databases

CTDi23552.
DisGeNETi23552.
GeneCardsiCDK20.
HGNCiHGNC:21420. CDK20.
HPAiHPA007666.
HPA027379.
HPA027401.
MIMi610076. gene.
neXtProtiNX_Q8IZL9.
OpenTargetsiENSG00000156345.
PharmGKBiPA165585688.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0659. Eukaryota.
ENOG410XQDH. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ8IZL9.
KOiK08817.
OMAiKAKHIET.
OrthoDBiEOG091G0CI9.
PhylomeDBiQ8IZL9.
TreeFamiTF327240.

Enzyme and pathway databases

BioCyciZFISH:HS08120-MONOMER.
SignaLinkiQ8IZL9.
SIGNORiQ8IZL9.

Miscellaneous databases

ChiTaRSiCDK20. human.
GenomeRNAii23552.
PROiQ8IZL9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156345.
CleanExiHS_CCRK.
ExpressionAtlasiQ8IZL9. baseline and differential.
GenevisibleiQ8IZL9. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK20_HUMAN
AccessioniPrimary (citable) accession number: Q8IZL9
Secondary accession number(s): A2A389
, A2A390, B4DQX1, O95137, Q5EDC4, Q5VYW1, Q9BUF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.