Unreviewed, UniProtKB/TrEMBL Q8IZK7 (Q8IZK7_HUMAN)

Names and origin

Protein names	Submitted name:     TWE-PRIL EMBL AAL90443.1
Organism	Homo sapiens (Human) EMBL AAL90443.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Biological process	cell death Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: Compara membrane Inferred from electronic annotation. Source: InterPro
Molecular function	tumor necrosis factor receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IZK7-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: FC6F3BCA29C029AE	FASTA	330	36,589
	10 20 30 40 50 60 MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL SAQEPAQEEL 70 80 90 100 110 120 VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK TRARRAIAAH YEVHPRPGQD 130 140 150 160 170 180 GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQSSDA LEAWENGERS 190 200 210 220 230 240 RKRRAVLTQK QKKQHSVLHL VPINATSKDD SDVTEVMWQP ALRRGRGLQA QGYGVRIQDA 250 260 270 280 290 300 GVYLLYSQVL FQDVTFTMGQ VVSREGQGRQ ETLFRCIRSM PSHPDRAYNS CYSAGVFHLH 310 320 330 QGDILSVIIP RARAKLNLSP HGTFLGFVKL

References

[1]

"An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein." Pradet-Balade B., Medema J.P., Lopez-Fraga M., Lozano J.C., Kolfschoten G.M., Picard A., Martinez-A C., Garcia-Sanz J.A., Hahne M. EMBO J. 21:5711-5720(2002) [PubMed: 12411489] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY081051 mRNA. Translation: AAL90443.1.
IPI	IPI00218017.
RefSeq	NP_742086.1.
UniGene	Hs.54673
3D structure databases
HSSP	HSSP built from PDB template 1KXG based on UniProtKB Q9Y275.
SMR	Q8IZK7. Positions 194-330.
ModBase	Search...
Proteomic databases
PRIDE	Q8IZK7.
Genome annotation databases
Ensembl	ENSG00000161955. Homo sapiens. [Contig view]
GeneID	407977.
KEGG	hsa:407977.
Organism-specific databases
HGNC	HGNC:11927. TNFSF12. HGNC:11928. TNFSF13.
Phylogenomic databases
HOGENOM	Q8IZK7.
HOVERGEN	Q8IZK7.
OMA	Q8IZK7. RVWDAGV.
Gene expression databases
ArrayExpress	Q8IZK7.
Bgee	Q8IZK7.
Family and domain databases
InterPro	IPR006052. TNF_family. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
Pfam	PF00229. TNF. 2 hits. [Graphical view]
SMART	SM00207. TNF. 1 hit. [Graphical view]
PROSITE	PS00251. TNF_1. 1 hit. PS50049. TNF_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	108346.
PMAP-CutDB	Q8IZK7.

Entry information

Entry name

Q8IZK7_HUMAN

Accession

Primary (citable) accession number: Q8IZK7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)