Q8IZK7 (Q8IZK7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
TWE-PRIL EMBL AAL90443.1

Submitted name:
Uncharacterized protein Ensembl ENSP00000430440 Ensembl ENSP00000451451 Ensembl ENSP00000293826

Gene names

Name:	TNFSF12 Ensembl ENSP00000430440 Ensembl ENSP00000451451
Synonyms:	TNFSF12-TNFSF13 Ensembl ENSP00000293826

Organism

Homo sapiens (Human) EMBL AAL90443.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Cytokine SAAS SAAS008983
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	immune response Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: InterPro
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW tumor necrosis factor receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IZK7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: FC6F3BCA29C029AE	FASTA	330	36,589
	10 20 30 40 50 60 MAARRSQRRR GRRGEPGTAL LVPLALGLGL ALACLGLLLA VVSLGSRASL SAQEPAQEEL 70 80 90 100 110 120 VAEEDQDPSE LNPQTEESQD PAPFLNRLVR PRRSAPKGRK TRARRAIAAH YEVHPRPGQD 130 140 150 160 170 180 GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQSSDA LEAWENGERS 190 200 210 220 230 240 RKRRAVLTQK QKKQHSVLHL VPINATSKDD SDVTEVMWQP ALRRGRGLQA QGYGVRIQDA 250 260 270 280 290 300 GVYLLYSQVL FQDVTFTMGQ VVSREGQGRQ ETLFRCIRSM PSHPDRAYNS CYSAGVFHLH 310 320 330 QGDILSVIIP RARAKLNLSP HGTFLGFVKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein." Pradet-Balade B., Medema J.P., Lopez-Fraga M., Lozano J.C., Kolfschoten G.M., Picard A., Martinez-A C., Garcia-Sanz J.A., Hahne M. EMBO J. 21:5711-5720(2002) [PubMed: 12411489] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Ensembl Submitted (JUN-2011) to UniProtKB Cited for: IDENTIFICATION.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
[5]	Ensembl Submitted (SEP-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC016876 Genomic DNA. No translation available. AY081051 mRNA. Translation: AAL90443.1.
IPI	IPI00218017.
RefSeq	NP_742086.1. NM_172089.3.
UniGene	Hs.54673.
3D structure databases
HSSP	HSSP built from PDB template 1KXG based on UniProtKB Q9Y275.
ProteinModelPortal	Q8IZK7.
SMR	Q8IZK7. Positions 108-168, 194-330.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IZK7.
Proteomic databases
PRIDE	Q8IZK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293826; ENSP00000293826; ENSG00000248871. ENST00000518220; ENSP00000430440; ENSG00000239697. ENST00000557233; ENSP00000451451; ENSG00000239697.
GeneID	407977.
KEGG	hsa:407977.
UCSC	uc002ghi.1. human.
Organism-specific databases
CTD	407977.
HGNC	HGNC:11927. TNFSF12. HGNC:33537. TNFSF12-TNFSF13.
PharmGKB	PA162406662.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063837.
HOVERGEN	HBG055511.
OMA	LRLCQTE.
OrthoDB	EOG4CZBH5.
PhylomeDB	Q8IZK7.
Gene expression databases
ArrayExpress	Q8IZK7.
Bgee	Q8IZK7.
Family and domain databases
InterPro	IPR006052. TNF. IPR021184. TNF_CS. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 2 hits.
Pfam	PF00229. TNF. 2 hits. [Graphical view]
SMART	SM00207. TNF. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 2 hits.
PROSITE	PS00251. TNF_1. 1 hit. PS50049. TNF_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	108346.
PMAP-CutDB	Q8IZK7.

Entry information

Entry name

Q8IZK7_HUMAN

Accession

Primary (citable) accession number: Q8IZK7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.