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Q8IZJ6

- TDH_HUMAN

UniProt

Q8IZJ6 - TDH_HUMAN

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Protein

Inactive L-threonine 3-dehydrogenase, mitochondrial

Gene

TDH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. coenzyme binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive L-threonine 3-dehydrogenase, mitochondrial
Gene namesi
Name:TDHImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15547. TDH.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 230Inactive L-threonine 3-dehydrogenase, mitochondrialPRO_0000298783
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiQ8IZJ6.
PRIDEiQ8IZJ6.

Expressioni

Tissue specificityi

Expressed in all tissues examined. Detected in most cell types examined, but not observed in endothelial cells, glioma cell lines and some leukemia cell lines.1 Publication

Gene expression databases

GenevestigatoriQ8IZJ6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317255.

Structurei

3D structure databases

ProteinModelPortaliQ8IZJ6.
SMRiQ8IZJ6. Positions 51-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0451.
HOGENOMiHOG000151268.
HOVERGENiHBG071436.
InParanoidiQ8IZJ6.
PhylomeDBiQ8IZJ6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8IZJ6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFIRMLRRA GQSPACGCWT PVLPVRFLGI SPRQIPADAN FHSASFSDTD
60 70 80 90 100
HPRVLITGAL GQLGVGLANL LRKRFGKDSV ILSDIRKPPD HVFHSGPFIY
110 120 130 140 150
SDILDYKNLR EIVVNNRITW LFHYSALLSA FGEANVSLAR AVNITGLHNI
160 170 180 190 200
LDVAAEHNLQ LFVPSTIGAF GPTSPRNPTP DLCIQRPRTI YGVSKVHAEL
210 220 230
MGETMQSRFS MMPQSMANSS ATWKPARDCP
Length:230
Mass (Da):25,407
Last modified:March 1, 2003 - v1
Checksum:i4163D462B322EF98
GO
Isoform 21 Publication (identifier: Q8IZJ6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-146: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:180
Mass (Da):19,739
Checksum:iB7E33C75DF17B126
GO
Isoform 31 Publication (identifier: Q8IZJ6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-146: Missing.
     204-207: TMQS → ISDA
     208-230: Missing.

Show »
Length:157
Mass (Da):17,096
Checksum:i7B04CDA42DFEF304
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851I → R in AAM50037. (PubMed:12361482)Curated
Sequence conflicti85 – 851I → R in BAB71562. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei97 – 14650Missing in isoform 2 and isoform 3. 2 PublicationsVSP_052507Add
BLAST
Alternative sequencei204 – 2074TMQS → ISDA in isoform 3. 1 PublicationVSP_052508
Alternative sequencei208 – 23023Missing in isoform 3. 1 PublicationVSP_052509Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY101186 mRNA. Translation: AAM50036.1.
AY101187 mRNA. Translation: AAM50037.1.
AK057762 mRNA. Translation: BAB71562.1.
AF131216 Genomic DNA. No translation available.
UniGeneiHs.583896.

Polymorphism databases

DMDMi74714590.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY101186 mRNA. Translation: AAM50036.1 .
AY101187 mRNA. Translation: AAM50037.1 .
AK057762 mRNA. Translation: BAB71562.1 .
AF131216 Genomic DNA. No translation available.
UniGenei Hs.583896.

3D structure databases

ProteinModelPortali Q8IZJ6.
SMRi Q8IZJ6. Positions 51-199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000317255.

Polymorphism databases

DMDMi 74714590.

Proteomic databases

PaxDbi Q8IZJ6.
PRIDEi Q8IZJ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC08P011198.
H-InvDB HIX0007313.
HGNCi HGNC:15547. TDH.
MIMi 615174. gene.
neXtProti NX_Q8IZJ6.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0451.
HOGENOMi HOG000151268.
HOVERGENi HBG071436.
InParanoidi Q8IZJ6.
PhylomeDBi Q8IZJ6.

Miscellaneous databases

PROi Q8IZJ6.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8IZJ6.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01370. Epimerase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human L-threonine 3-dehydrogenase gene is an expressed pseudogene."
    Edgar A.J.
    BMC Genet. 3:18-18(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY.
    Tissue: LiverImported.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: CerebellumImported.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTDH_HUMAN
AccessioniPrimary (citable) accession number: Q8IZJ6
Secondary accession number(s): Q8IZJ5, Q96LV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3