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Protein

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8

Gene

CPAMD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei671 – 6722Cleavage; by furin-like proteaseCurated

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
Gene namesi
Name:CPAMD8
Synonyms:KIAA1283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23228. CPAMD8.

Subcellular locationi

Secreted 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Extracellular side 1 Publication

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 18851860C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8PRO_0000317695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi757 – 7571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1439 – 14391N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Proteolytically cleaved into 2 chains of about 70 and 130 kDa. The fragments are not connected by disulfide bonds.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZJ3.
PRIDEiQ8IZJ3.

PTM databases

PhosphoSiteiQ8IZJ3.

Expressioni

Tissue specificityi

Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine.1 Publication

Inductioni

Up-regulated by IL1B/interleukin-1 beta and IL6/interleukin-6.1 Publication

Gene expression databases

BgeeiQ8IZJ3.
CleanExiHS_CPAMD8.
ExpressionAtlasiQ8IZJ3. baseline and differential.
GenevestigatoriQ8IZJ3.

Organism-specific databases

HPAiHPA031327.
HPA031328.
HPA031330.

Interactioni

Subunit structurei

Interacts with heparin.1 Publication

Protein-protein interaction databases

BioGridi118033. 3 interactions.
STRINGi9606.ENSP00000291440.

Structurei

3D structure databases

ProteinModelPortaliQ8IZJ3.
SMRiQ8IZJ3. Positions 30-948, 1107-1681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1706 – 175752Kazal-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi668 – 6714Poly-Arg
Compositional biasi1242 – 12454Poly-Gln
Compositional biasi1540 – 15434Poly-Asp
Compositional biasi1765 – 17684Poly-Ser

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG241555.
HOGENOMiHOG000168521.
HOVERGENiHBG107753.
InParanoidiQ8IZJ3.
OrthoDBiEOG747PH3.
PhylomeDBiQ8IZJ3.
TreeFamiTF313285.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR002350. Kazal_dom.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR022041. Methyltransf_FA.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF07648. Kazal_2. 1 hit.
PF12248. Methyltransf_FA. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGALLWPLL PLLLLLLSAR DGVRAAQPQA PGYLIAAPSV FRAGVEEVIS
60 70 80 90 100
VTIFNSPREV TVQAQLVAQG EPVVQSQGAI LDKGTIKLKV PTGLRGQALL
110 120 130 140 150
KVWGRGWQAE EGPLFHNQTS VTVDGRGASV FIQTDKPVYR PQHRVLISIF
160 170 180 190 200
TVSPNLRPVN EKLEAYILDP RGSRMIEWRH LKPFCCGITN MSFPLSDQPV
210 220 230 240 250
LGEWFIFVEM QGHAYNKSFE VQKYVLPKFE LLIDPPRYIQ DLDACETGTV
260 270 280 290 300
RARYTFGKPV AGALMINMTV NGVGYYSHEV GRPVLRTTKI LGSRDFDICV
310 320 330 340 350
RDMIPADVPE HFRGRVSIWA MVTSVDGSQQ VAFDDSTPVQ RQLVDIRYSK
360 370 380 390 400
DTRKQFKPGL AYVGKVELSY PDGSPAEGVT VQIKAELTPK DNIYTSEVVS
410 420 430 440 450
QRGLVGFEIP SIPTSAQHVW LETKVMALNG KPVGAQYLPS YLSLGSWYSP
460 470 480 490 500
SQCYLQLQPP SHPLQVGEEA YFSVKSTCPC NFTLYYEVAA RGNIVLSGQQ
510 520 530 540 550
PAHTTQQRSK RAAPALEKPI RLTHLSETEP PPAPEAEVDV CVTSLHLAVT
560 570 580 590 600
PSMVPLGRLL VFYVRENGEG VADSLQFAVE TFFENQVSVT YSANETQPGE
610 620 630 640 650
VVDLRIRAAR GSCVCVAAVD KSVYLLRSGF RLTPAQVFQE LEDYDVSDSF
660 670 680 690 700
GVSREDGPFW WAGLTAQRRR RSSVFPWPWG ITKDSGFAFT ETGLVVMTDR
710 720 730 740 750
VSLNHRQDGG LYTDEAVPAF QPHTGSLVAV APSRHPPRTE KRKRTFFPET
760 770 780 790 800
WIWHCLNISD PSGEGTLSVK VPDSITSWVG EAVALSTSQG LGIAEPSLLK
810 820 830 840 850
TFKPFFVDFM LPALIIRGEQ VKIPLSVYNY MGTCAEVYMK LSVPKGIQFV
860 870 880 890 900
GHPGKRHVTK KMCVAPGEAE PIWVVLSFSD LGLNNITAKA LAYGDTNCCR
910 920 930 940 950
DGRSSKHPEE NHADRRVPIG VDHVRRSVMV EAEGVPRAYT YSAFFCPSER
960 970 980 990 1000
VHISTPNKYE FQYVQRPLRL TRFDVAVRAH NDARVALSSG PQDTAGMIEI
1010 1020 1030 1040 1050
VLGGHQNTRS WISTSKMGEP VASAHTAKIL SWDEFRTFWI SWRGGLIQVG
1060 1070 1080 1090 1100
HGPEPSNESV IVAWTLPRPP EVQFIGFSTG WGSMGEFRIW RKMEVDESYS
1110 1120 1130 1140 1150
EAFTLGVPHG AIPGSERATA SIIGDVMGPT LNHLNNLLRL PFGCGEQNMI
1160 1170 1180 1190 1200
HFAPNVFVLK YLQKTQQLSP EVERETTDYL VQGYQRQLTY KRQDGSYSAF
1210 1220 1230 1240 1250
GERDASGSMW LTAFVLKSFA QARSFIFVDP RELAAAKSWI IQQQQADGSF
1260 1270 1280 1290 1300
LAVGRVLNKD IQGGIHGTVP LTAYVVVALL ETGTASEEER GSTDKARHFL
1310 1320 1330 1340 1350
ESAAPLAMDP YSCALTTYAL TLLRSPAAPE ALRKLRSLAI MRDGVTHWSL
1360 1370 1380 1390 1400
SNSWDVDKGT FLSFSDRVSQ SVVSAEVEMT AYALLTYTLL GDVAAALPVV
1410 1420 1430 1440 1450
KWLSQQRNAL GGFSSTQDTC VALQALAEYA ILSYAGGINL TVSLASTNLD
1460 1470 1480 1490 1500
YQETFELHRT NQKVLQTAAI PSLPTGLFVS AKGDGCCLMQ IDVTYNVPDP
1510 1520 1530 1540 1550
VAKPAFQLLV SLQEPEAQGR PPPMPASAAE GSRGDWPPAD DDDPAADQHH
1560 1570 1580 1590 1600
QEYKVMLEVC TRWLHAGSSN MAVLEVPLLS GFRADIESLE QLLLDKHMGM
1610 1620 1630 1640 1650
KRYEVAGRRV LFYFDEIPSR CLTCVRFRAL RECVVGRTSA LPVSVYDYYE
1660 1670 1680 1690 1700
PAFEATRFYN VSTHSPLARE LCAGPACNEV ERAPARGPGW FPGESGPAVA
1710 1720 1730 1740 1750
PEEGAAIARC GCDHDCGAQG NPVCGSDGVV YASACRLREA ACRQAAPLEP
1760 1770 1780 1790 1800
APPSCCALEQ RLPASSSSTY GDDLASVAPG PLQQDVKLNG AGLEVEDSDP
1810 1820 1830 1840 1850
EPEGEAEDRV TAGPRPPVSS GNLESSTQSA SPFHRWGQTP APQRHSGRVV
1860 1870 1880
GAHRPGLLSP VFVYSPAFQS GGEEGLWMSN TCTLR
Length:1,885
Mass (Da):206,702
Last modified:September 22, 2009 - v2
Checksum:i5AA522DE6155C288
GO
Isoform 2 (identifier: Q8IZJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1809-1815: RVTAGPR → SQSGFSS
     1816-1885: Missing.

Note: No experimental confirmation available.

Show »
Length:1,815
Mass (Da):199,171
Checksum:iE8F8D6DA1DECDB6D
GO

Sequence cautioni

The sequence BAC11400.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1588 – 15881S → G in BAC11400 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511R → W.
Corresponds to variant rs10426545 [ dbSNP | Ensembl ].
VAR_038655
Natural varianti265 – 2651M → T.
Corresponds to variant rs4808551 [ dbSNP | Ensembl ].
VAR_038656
Natural varianti294 – 2941R → Q.2 Publications
Corresponds to variant rs3745340 [ dbSNP | Ensembl ].
VAR_038657
Natural varianti539 – 5391D → E.
Corresponds to variant rs3745335 [ dbSNP | Ensembl ].
VAR_038658
Natural varianti546 – 5461H → R.
Corresponds to variant rs1824152 [ dbSNP | Ensembl ].
VAR_038659
Natural varianti736 – 7361P → H.
Corresponds to variant rs9305083 [ dbSNP | Ensembl ].
VAR_038660
Natural varianti1156 – 11561V → I.
Corresponds to variant rs2250918 [ dbSNP | Ensembl ].
VAR_038661
Natural varianti1268 – 12681T → I.2 Publications
Corresponds to variant rs706761 [ dbSNP | Ensembl ].
VAR_038662
Natural varianti1843 – 18431Q → R.
Corresponds to variant rs1054533 [ dbSNP | Ensembl ].
VAR_038663

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1809 – 18157RVTAGPR → SQSGFSS in isoform 2. 1 PublicationVSP_031137
Alternative sequencei1816 – 188570Missing in isoform 2. 1 PublicationVSP_031138Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY101765 mRNA. Translation: AAM50084.1.
AC008737 Genomic DNA. No translation available.
AC020908 Genomic DNA. No translation available.
AB033109 mRNA. Translation: BAA86597.1.
AK075099 mRNA. Translation: BAC11400.1. Different initiation.
RefSeqiNP_056507.2. NM_015692.2.
UniGeneiHs.631644.

Genome annotation databases

EnsembliENST00000291440; ENSP00000291440; ENSG00000160111.
ENST00000443236; ENSP00000402505; ENSG00000160111.
GeneIDi27151.
KEGGihsa:27151.
UCSCiuc002nfb.3. human. [Q8IZJ3-1]

Polymorphism databases

DMDMi259016204.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY101765 mRNA. Translation: AAM50084.1.
AC008737 Genomic DNA. No translation available.
AC020908 Genomic DNA. No translation available.
AB033109 mRNA. Translation: BAA86597.1.
AK075099 mRNA. Translation: BAC11400.1. Different initiation.
RefSeqiNP_056507.2. NM_015692.2.
UniGeneiHs.631644.

3D structure databases

ProteinModelPortaliQ8IZJ3.
SMRiQ8IZJ3. Positions 30-948, 1107-1681.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118033. 3 interactions.
STRINGi9606.ENSP00000291440.

PTM databases

PhosphoSiteiQ8IZJ3.

Polymorphism databases

DMDMi259016204.

Proteomic databases

PaxDbiQ8IZJ3.
PRIDEiQ8IZJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291440; ENSP00000291440; ENSG00000160111.
ENST00000443236; ENSP00000402505; ENSG00000160111.
GeneIDi27151.
KEGGihsa:27151.
UCSCiuc002nfb.3. human. [Q8IZJ3-1]

Organism-specific databases

CTDi27151.
GeneCardsiGC19M017003.
H-InvDBHIX0014878.
HGNCiHGNC:23228. CPAMD8.
HPAiHPA031327.
HPA031328.
HPA031330.
MIMi608841. gene.
neXtProtiNX_Q8IZJ3.
PharmGKBiPA134915057.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG241555.
HOGENOMiHOG000168521.
HOVERGENiHBG107753.
InParanoidiQ8IZJ3.
OrthoDBiEOG747PH3.
PhylomeDBiQ8IZJ3.
TreeFamiTF313285.

Miscellaneous databases

GenomeRNAii27151.
NextBioi49911.
PROiQ8IZJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZJ3.
CleanExiHS_CPAMD8.
ExpressionAtlasiQ8IZJ3. baseline and differential.
GenevestigatoriQ8IZJ3.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR002350. Kazal_dom.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR022041. Methyltransf_FA.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF07648. Kazal_2. 1 hit.
PF12248. Methyltransf_FA. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of CPAMD8, a novel member of the complement 3/alpha2-macroglobulin family with a C-terminal Kazal domain."
    Li Z.-F., Wu X.-H., Engvall E.
    Genomics 83:1083-1093(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, CLEAVAGE BY FURIN-LIKE PROTEASE, SUBCELLULAR LOCATION, INDUCTION BY IL1B AND IL6, INTERACTION WITH HEPARIN, VARIANTS GLN-294 AND ILE-1268.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1885 (ISOFORM 1), VARIANTS GLN-294 AND ILE-1268.
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1479-1885 (ISOFORM 2).
    Tissue: Placenta.

Entry informationi

Entry nameiCPMD8_HUMAN
AccessioniPrimary (citable) accession number: Q8IZJ3
Secondary accession number(s): Q8NC09, Q9ULD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 22, 2009
Last modified: March 4, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.