Q8IZJ3 (CPMD8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8

Gene names

Name:	CPAMD8
Synonyms:	KIAA1283

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1885 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with heparin. Ref.1
Subcellular location	Secreted Probable. Cell membrane; Peripheral membrane protein; Extracellular side Ref.1.
Tissue specificity	Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Ref.1
Induction	Up-regulated by IL1B/interleukin-1 beta and IL6/interleukin-6. Ref.1
Post-translational modification	Proteolytically cleaved into 2 chains of about 70 and 130 kDa. The fragments are not connected by disulfide bonds. Ref.1
Sequence similarities	Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification] Contains 1 Kazal-like domain.
Sequence caution	The sequence BAC11400.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZJ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZJ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1809-1815: RVTAGPR → SQSGFSS
     1816-1885: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 1885	1860	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8		PRO_0000317695
Regions
	Domain	1706 – 1757	52	Kazal-like
	Compositional bias	668 – 671	4	Poly-Arg
	Compositional bias	1242 – 1245	4	Poly-Gln
	Compositional bias	1540 – 1543	4	Poly-Asp
	Compositional bias	1765 – 1768	4	Poly-Ser
Sites
	Site	671 – 672	2	Cleavage; by furin-like protease Probable
Amino acid modifications
	Glycosylation	117	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Glycosylation	267	1	N-linked (GlcNAc...) Potential
	Glycosylation	757	1	N-linked (GlcNAc...) Potential
	Glycosylation	1439	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1809 – 1815	7	RVTAGPR → SQSGFSS in isoform 2.		VSP_031137
	Alternative sequence	1816 – 1885	70	Missing in isoform 2.		VSP_031138
	Natural variant	251	1	R → W. Corresponds to variant rs10426545 [ dbSNP | Ensembl ].		VAR_038655
	Natural variant	265	1	M → T. Corresponds to variant rs4808551 [ dbSNP | Ensembl ].		VAR_038656
	Natural variant	294	1	R → Q. Ref.1 Ref.3 Corresponds to variant rs3745340 [ dbSNP | Ensembl ].		VAR_038657
	Natural variant	539	1	D → E. Corresponds to variant rs3745335 [ dbSNP | Ensembl ].		VAR_038658
	Natural variant	546	1	H → R. Corresponds to variant rs1824152 [ dbSNP | Ensembl ].		VAR_038659
	Natural variant	736	1	P → H. Corresponds to variant rs9305083 [ dbSNP | Ensembl ].		VAR_038660
	Natural variant	1156	1	V → I. Corresponds to variant rs2250918 [ dbSNP | Ensembl ].		VAR_038661
	Natural variant	1268	1	T → I. Ref.1 Ref.3 Corresponds to variant rs706761 [ dbSNP | Ensembl ].		VAR_038662
	Natural variant	1843	1	Q → R. Corresponds to variant rs1054533 [ dbSNP | Ensembl ].		VAR_038663
Experimental info
	Sequence conflict	1588	1	S → G in BAC11400. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 5AA522DE6155C288	FASTA	1,885	206,702
	10 20 30 40 50 60 MSGALLWPLL PLLLLLLSAR DGVRAAQPQA PGYLIAAPSV FRAGVEEVIS VTIFNSPREV 70 80 90 100 110 120 TVQAQLVAQG EPVVQSQGAI LDKGTIKLKV PTGLRGQALL KVWGRGWQAE EGPLFHNQTS 130 140 150 160 170 180 VTVDGRGASV FIQTDKPVYR PQHRVLISIF TVSPNLRPVN EKLEAYILDP RGSRMIEWRH 190 200 210 220 230 240 LKPFCCGITN MSFPLSDQPV LGEWFIFVEM QGHAYNKSFE VQKYVLPKFE LLIDPPRYIQ 250 260 270 280 290 300 DLDACETGTV RARYTFGKPV AGALMINMTV NGVGYYSHEV GRPVLRTTKI LGSRDFDICV 310 320 330 340 350 360 RDMIPADVPE HFRGRVSIWA MVTSVDGSQQ VAFDDSTPVQ RQLVDIRYSK DTRKQFKPGL 370 380 390 400 410 420 AYVGKVELSY PDGSPAEGVT VQIKAELTPK DNIYTSEVVS QRGLVGFEIP SIPTSAQHVW 430 440 450 460 470 480 LETKVMALNG KPVGAQYLPS YLSLGSWYSP SQCYLQLQPP SHPLQVGEEA YFSVKSTCPC 490 500 510 520 530 540 NFTLYYEVAA RGNIVLSGQQ PAHTTQQRSK RAAPALEKPI RLTHLSETEP PPAPEAEVDV 550 560 570 580 590 600 CVTSLHLAVT PSMVPLGRLL VFYVRENGEG VADSLQFAVE TFFENQVSVT YSANETQPGE 610 620 630 640 650 660 VVDLRIRAAR GSCVCVAAVD KSVYLLRSGF RLTPAQVFQE LEDYDVSDSF GVSREDGPFW 670 680 690 700 710 720 WAGLTAQRRR RSSVFPWPWG ITKDSGFAFT ETGLVVMTDR VSLNHRQDGG LYTDEAVPAF 730 740 750 760 770 780 QPHTGSLVAV APSRHPPRTE KRKRTFFPET WIWHCLNISD PSGEGTLSVK VPDSITSWVG 790 800 810 820 830 840 EAVALSTSQG LGIAEPSLLK TFKPFFVDFM LPALIIRGEQ VKIPLSVYNY MGTCAEVYMK 850 860 870 880 890 900 LSVPKGIQFV GHPGKRHVTK KMCVAPGEAE PIWVVLSFSD LGLNNITAKA LAYGDTNCCR 910 920 930 940 950 960 DGRSSKHPEE NHADRRVPIG VDHVRRSVMV EAEGVPRAYT YSAFFCPSER VHISTPNKYE 970 980 990 1000 1010 1020 FQYVQRPLRL TRFDVAVRAH NDARVALSSG PQDTAGMIEI VLGGHQNTRS WISTSKMGEP 1030 1040 1050 1060 1070 1080 VASAHTAKIL SWDEFRTFWI SWRGGLIQVG HGPEPSNESV IVAWTLPRPP EVQFIGFSTG 1090 1100 1110 1120 1130 1140 WGSMGEFRIW RKMEVDESYS EAFTLGVPHG AIPGSERATA SIIGDVMGPT LNHLNNLLRL 1150 1160 1170 1180 1190 1200 PFGCGEQNMI HFAPNVFVLK YLQKTQQLSP EVERETTDYL VQGYQRQLTY KRQDGSYSAF 1210 1220 1230 1240 1250 1260 GERDASGSMW LTAFVLKSFA QARSFIFVDP RELAAAKSWI IQQQQADGSF LAVGRVLNKD 1270 1280 1290 1300 1310 1320 IQGGIHGTVP LTAYVVVALL ETGTASEEER GSTDKARHFL ESAAPLAMDP YSCALTTYAL 1330 1340 1350 1360 1370 1380 TLLRSPAAPE ALRKLRSLAI MRDGVTHWSL SNSWDVDKGT FLSFSDRVSQ SVVSAEVEMT 1390 1400 1410 1420 1430 1440 AYALLTYTLL GDVAAALPVV KWLSQQRNAL GGFSSTQDTC VALQALAEYA ILSYAGGINL 1450 1460 1470 1480 1490 1500 TVSLASTNLD YQETFELHRT NQKVLQTAAI PSLPTGLFVS AKGDGCCLMQ IDVTYNVPDP 1510 1520 1530 1540 1550 1560 VAKPAFQLLV SLQEPEAQGR PPPMPASAAE GSRGDWPPAD DDDPAADQHH QEYKVMLEVC 1570 1580 1590 1600 1610 1620 TRWLHAGSSN MAVLEVPLLS GFRADIESLE QLLLDKHMGM KRYEVAGRRV LFYFDEIPSR 1630 1640 1650 1660 1670 1680 CLTCVRFRAL RECVVGRTSA LPVSVYDYYE PAFEATRFYN VSTHSPLARE LCAGPACNEV 1690 1700 1710 1720 1730 1740 ERAPARGPGW FPGESGPAVA PEEGAAIARC GCDHDCGAQG NPVCGSDGVV YASACRLREA 1750 1760 1770 1780 1790 1800 ACRQAAPLEP APPSCCALEQ RLPASSSSTY GDDLASVAPG PLQQDVKLNG AGLEVEDSDP 1810 1820 1830 1840 1850 1860 EPEGEAEDRV TAGPRPPVSS GNLESSTQSA SPFHRWGQTP APQRHSGRVV GAHRPGLLSP 1870 1880 VFVYSPAFQS GGEEGLWMSN TCTLR
	Isoform 2 [UniParc]. Checksum: E8F8D6DA1DECDB6D	FASTA	1,815	199,171
	10 20 30 40 50 60 MSGALLWPLL PLLLLLLSAR DGVRAAQPQA PGYLIAAPSV FRAGVEEVIS VTIFNSPREV 70 80 90 100 110 120 TVQAQLVAQG EPVVQSQGAI LDKGTIKLKV PTGLRGQALL KVWGRGWQAE EGPLFHNQTS 130 140 150 160 170 180 VTVDGRGASV FIQTDKPVYR PQHRVLISIF TVSPNLRPVN EKLEAYILDP RGSRMIEWRH 190 200 210 220 230 240 LKPFCCGITN MSFPLSDQPV LGEWFIFVEM QGHAYNKSFE VQKYVLPKFE LLIDPPRYIQ 250 260 270 280 290 300 DLDACETGTV RARYTFGKPV AGALMINMTV NGVGYYSHEV GRPVLRTTKI LGSRDFDICV 310 320 330 340 350 360 RDMIPADVPE HFRGRVSIWA MVTSVDGSQQ VAFDDSTPVQ RQLVDIRYSK DTRKQFKPGL 370 380 390 400 410 420 AYVGKVELSY PDGSPAEGVT VQIKAELTPK DNIYTSEVVS QRGLVGFEIP SIPTSAQHVW 430 440 450 460 470 480 LETKVMALNG KPVGAQYLPS YLSLGSWYSP SQCYLQLQPP SHPLQVGEEA YFSVKSTCPC 490 500 510 520 530 540 NFTLYYEVAA RGNIVLSGQQ PAHTTQQRSK RAAPALEKPI RLTHLSETEP PPAPEAEVDV 550 560 570 580 590 600 CVTSLHLAVT PSMVPLGRLL VFYVRENGEG VADSLQFAVE TFFENQVSVT YSANETQPGE 610 620 630 640 650 660 VVDLRIRAAR GSCVCVAAVD KSVYLLRSGF RLTPAQVFQE LEDYDVSDSF GVSREDGPFW 670 680 690 700 710 720 WAGLTAQRRR RSSVFPWPWG ITKDSGFAFT ETGLVVMTDR VSLNHRQDGG LYTDEAVPAF 730 740 750 760 770 780 QPHTGSLVAV APSRHPPRTE KRKRTFFPET WIWHCLNISD PSGEGTLSVK VPDSITSWVG 790 800 810 820 830 840 EAVALSTSQG LGIAEPSLLK TFKPFFVDFM LPALIIRGEQ VKIPLSVYNY MGTCAEVYMK 850 860 870 880 890 900 LSVPKGIQFV GHPGKRHVTK KMCVAPGEAE PIWVVLSFSD LGLNNITAKA LAYGDTNCCR 910 920 930 940 950 960 DGRSSKHPEE NHADRRVPIG VDHVRRSVMV EAEGVPRAYT YSAFFCPSER VHISTPNKYE 970 980 990 1000 1010 1020 FQYVQRPLRL TRFDVAVRAH NDARVALSSG PQDTAGMIEI VLGGHQNTRS WISTSKMGEP 1030 1040 1050 1060 1070 1080 VASAHTAKIL SWDEFRTFWI SWRGGLIQVG HGPEPSNESV IVAWTLPRPP EVQFIGFSTG 1090 1100 1110 1120 1130 1140 WGSMGEFRIW RKMEVDESYS EAFTLGVPHG AIPGSERATA SIIGDVMGPT LNHLNNLLRL 1150 1160 1170 1180 1190 1200 PFGCGEQNMI HFAPNVFVLK YLQKTQQLSP EVERETTDYL VQGYQRQLTY KRQDGSYSAF 1210 1220 1230 1240 1250 1260 GERDASGSMW LTAFVLKSFA QARSFIFVDP RELAAAKSWI IQQQQADGSF LAVGRVLNKD 1270 1280 1290 1300 1310 1320 IQGGIHGTVP LTAYVVVALL ETGTASEEER GSTDKARHFL ESAAPLAMDP YSCALTTYAL 1330 1340 1350 1360 1370 1380 TLLRSPAAPE ALRKLRSLAI MRDGVTHWSL SNSWDVDKGT FLSFSDRVSQ SVVSAEVEMT 1390 1400 1410 1420 1430 1440 AYALLTYTLL GDVAAALPVV KWLSQQRNAL GGFSSTQDTC VALQALAEYA ILSYAGGINL 1450 1460 1470 1480 1490 1500 TVSLASTNLD YQETFELHRT NQKVLQTAAI PSLPTGLFVS AKGDGCCLMQ IDVTYNVPDP 1510 1520 1530 1540 1550 1560 VAKPAFQLLV SLQEPEAQGR PPPMPASAAE GSRGDWPPAD DDDPAADQHH QEYKVMLEVC 1570 1580 1590 1600 1610 1620 TRWLHAGSSN MAVLEVPLLS GFRADIESLE QLLLDKHMGM KRYEVAGRRV LFYFDEIPSR 1630 1640 1650 1660 1670 1680 CLTCVRFRAL RECVVGRTSA LPVSVYDYYE PAFEATRFYN VSTHSPLARE LCAGPACNEV 1690 1700 1710 1720 1730 1740 ERAPARGPGW FPGESGPAVA PEEGAAIARC GCDHDCGAQG NPVCGSDGVV YASACRLREA 1750 1760 1770 1780 1790 1800 ACRQAAPLEP APPSCCALEQ RLPASSSSTY GDDLASVAPG PLQQDVKLNG AGLEVEDSDP 1810 EPEGEAEDSQ SGFSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of CPAMD8, a novel member of the complement 3/alpha2-macroglobulin family with a C-terminal Kazal domain." Li Z.-F., Wu X.-H., Engvall E. Genomics 83:1083-1093(2004) [PubMed: 15177561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MASS SPECTROMETRY, TISSUE SPECIFICITY, CLEAVAGE BY FURIN-LIKE PROTEASE, SUBCELLULAR LOCATION, INDUCTION BY IL1B AND IL6, INTERACTION WITH HEPARIN, VARIANTS GLN-294 AND ILE-1268.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1885 (ISOFORM 1), VARIANTS GLN-294 AND ILE-1268. Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1479-1885 (ISOFORM 2). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY101765 mRNA. Translation: AAM50084.1. AC008737 Genomic DNA. No translation available. AC020908 Genomic DNA. No translation available. AB033109 mRNA. Translation: BAA86597.1. AK075099 mRNA. Translation: BAC11400.1. Different initiation.
IPI	IPI00291807. IPI00783366.
RefSeq	NP_056507.2. NM_015692.2.
UniGene	Hs.631644. Hs.727790.
3D structure databases
HSSP	HSSP built from PDB template 1Y1B based on UniProtKB P16895.
ProteinModelPortal	Q8IZJ3.
SMR	Q8IZJ3. Positions 127-227, 736-949, 1132-1435, 1437-1757.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IZJ3.
PTM databases
PhosphoSite	Q8IZJ3.
Polymorphism databases
DMDM	259016204.
Proteomic databases
PRIDE	Q8IZJ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000291440; ENSP00000291440; ENSG00000160111. ENST00000443236; ENSP00000402505; ENSG00000160111.
GeneID	27151.
KEGG	hsa:27151.
UCSC	uc002nfb.1. human.
Organism-specific databases
CTD	27151.
GeneCards	GC19M017003.
H-InvDB	HIX0014878.
HGNC	HGNC:23228. CPAMD8.
HPA	HPA031330.
MIM	608841. gene.
neXtProt	NX_Q8IZJ3.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00560000076685.
HOVERGEN	HBG107753.
InParanoid	Q8IZJ3.
OrthoDB	EOG441Q9J.
Gene expression databases
ArrayExpress	Q8IZJ3.
Bgee	Q8IZJ3.
CleanEx	HS_CPAMD8.
Genevestigator	Q8IZJ3.
Family and domain databases
InterPro	IPR009048. A-macroglobulin_rcpt-bd. IPR011626. A2M_comp. IPR002890. A2M_N. IPR011625. A2M_N_2. IPR001599. Macroglobln_a2. IPR019742. MacrogloblnA2_CS. IPR019565. MacrogloblnA2_thiol-ester-bond. IPR022041. Methyltransf_FA. IPR002350. Prot_inh_Kazal. IPR011497. Prot_Inh_Kazal_2. IPR008930. Terpenoid_cyclase/PrenylTrfase. [Graphical view]
Gene3D	G3DSA:2.60.40.690. A-macroglobulin_rcpt-bd. 1 hit.
Pfam	PF00207. A2M. 1 hit. PF07678. A2M_comp. 1 hit. PF01835. A2M_N. 1 hit. PF07703. A2M_N_2. 1 hit. PF07677. A2M_recep. 1 hit. PF07648. Kazal_2. 1 hit. PF12248. Methyltransf_FA. 1 hit. PF10569. Thiol-ester_cl. 1 hit. [Graphical view]
SMART	SM00280. KAZAL. 1 hit. [Graphical view]
SUPFAM	SSF49410. AM_receptor_bind. 1 hit. SSF48239. Terp_cyc_toroid. 1 hit.
PROSITE	PS00477. ALPHA_2_MACROGLOBULIN. 1 hit. PS51465. KAZAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

CPMD8_HUMAN

Accession

Primary (citable) accession number: Q8IZJ3
Secondary accession number(s): Q8NC09, Q9ULD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 22, 2009
Last modified:	January 25, 2012
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.