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Q8IZJ1

- UNC5B_HUMAN

UniProt

Q8IZJ1 - UNC5B_HUMAN

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Protein

Netrin receptor UNC5B

Gene

UNC5B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei412 – 4132Cleavage; by caspase-3

GO - Biological processi

  1. anterior/posterior axon guidance Source: Ensembl
  2. apoptotic process Source: Reactome
  3. axon guidance Source: Reactome
  4. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
  5. negative regulation of neuron apoptotic process Source: UniProtKB
  6. positive regulation of apoptotic process Source: Reactome
  7. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  8. regulation of apoptotic process Source: Reactome
  9. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_22128. Role of DCC in regulating apoptosis.
REACT_22237. Netrin-1 signaling.
REACT_22384. Netrin mediated repulsion signals.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor UNC5B
Alternative name(s):
Protein unc-5 homolog 2
Protein unc-5 homolog B
p53-regulated receptor for death and life protein 1
Gene namesi
Name:UNC5B
Synonyms:P53RDL1, UNC5H2
ORF Names:UNQ1883/PRO4326
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:12568. UNC5B.

Subcellular locationi

Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: Associated with lipid raft.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi412 – 4121D → N: Abolishes cleavage by caspase-3 and subsequent induction of apoptosis. 1 Publication

Organism-specific databases

PharmGKBiPA37205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 945919Netrin receptor UNC5BPRO_0000036071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 128By similarity
Disulfide bondi174 ↔ 225By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi258 ↔ 295By similarity
Disulfide bondi262 ↔ 299By similarity
Disulfide bondi273 ↔ 285By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Lipidationi403 – 4031S-palmitoyl cysteine1 Publication

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosine residues.By similarity
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
Palmitoylation target the protein to the lipid rafts, and is required for pro-apoptotic activity.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ8IZJ1.
PaxDbiQ8IZJ1.
PRIDEiQ8IZJ1.

PTM databases

PhosphoSiteiQ8IZJ1.

Miscellaneous databases

PMAP-CutDBQ8IZJ1.

Expressioni

Tissue specificityi

Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.1 Publication

Inductioni

By p53/TP53.

Gene expression databases

BgeeiQ8IZJ1.
CleanExiHS_UNC5B.
GenevestigatoriQ8IZJ1.

Organism-specific databases

HPAiHPA011141.

Interactioni

Subunit structurei

Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part. Interacts (via death domain) with DAPK1 (via death domain).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Agap2Q8CGU49EBI-4409075,EBI-4409108From a different organism.

Protein-protein interaction databases

BioGridi128567. 2 interactions.
DIPiDIP-46275N.
IntActiQ8IZJ1. 2 interactions.
STRINGi9606.ENSP00000334329.

Structurei

3D structure databases

ProteinModelPortaliQ8IZJ1.
SMRiQ8IZJ1. Positions 48-353, 541-943.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 377351ExtracellularSequence AnalysisAdd
BLAST
Topological domaini399 – 945547CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 14598Ig-likeAdd
BLAST
Domaini147 – 24296Ig-like C2-typeAdd
BLAST
Domaini246 – 30055TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini302 – 35453TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini544 – 688145ZU5PROSITE-ProRule annotationAdd
BLAST
Domaini865 – 94379DeathAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni689 – 838150UPA domainBy similarityAdd
BLAST
Regioni707 – 72519Interaction with DCCBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the unc-5 family.Curated
Contains 1 death domain.Curated
Contains 2 TSP type-1 domains.PROSITE-ProRule annotation
Contains 1 ZU5 domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293019.
GeneTreeiENSGT00760000119076.
HOGENOMiHOG000060306.
HOVERGENiHBG056483.
InParanoidiQ8IZJ1.
KOiK07521.
OMAiHEVLLQC.
OrthoDBiEOG7BGHJX.
PhylomeDBiQ8IZJ1.
TreeFamiTF316767.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000884. Thrombospondin_1_rpt.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF07679. I-set. 1 hit.
PF00090. TSP_1. 2 hits.
PF00791. ZU5. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 2 hits.
SM00218. ZU5. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 2 hits.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZJ1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGARSGARGA LLLALLLCWD PRLSQAGTDS GSEVLPDSFP SAPAEPLPYF
60 70 80 90 100
LQEPQDAYIV KNKPVELRCR AFPATQIYFK CNGEWVSQND HVTQEGLDEA
110 120 130 140 150
TGLRVREVQI EVSRQQVEEL FGLEDYWCQC VAWSSAGTTK SRRAYVRIAY
160 170 180 190 200
LRKNFDQEPL GKEVPLDHEV LLQCRPPEGV PVAEVEWLKN EDVIDPTQDT
210 220 230 240 250
NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT VIVYVNGGWS
260 270 280 290 300
SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAF QKTACTTICP
310 320 330 340 350
VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD
360 370 380 390 400
GLCMQNKKTL SDPNSHLLEA SGDAALYAGL VVAIFVVVAI LMAVGVVVYR
410 420 430 440 450
RNCRDFDTDI TDSSAALTGG FHPVNFKTAR PSNPQLLHPS VPPDLTASAG
460 470 480 490 500
IYRGPVYALQ DSTDKIPMTN SPLLDPLPSL KVKVYSSSTT GSGPGLADGA
510 520 530 540 550
DLLGVLPPGT YPSDFARDTH FLHLRSASLG SQQLLGLPRD PGSSVSGTFG
560 570 580 590 600
CLGGRLSIPG TGVSLLVPNG AIPQGKFYEM YLLINKAEST LPLSEGTQTV
610 620 630 640 650
LSPSVTCGPT GLLLCRPVIL TMPHCAEVSA RDWIFQLKTQ AHQGHWEEVV
660 670 680 690 700
TLDEETLNTP CYCQLEPRAC HILLDQLGTY VFTGESYSRS AVKRLQLAVF
710 720 730 740 750
APALCTSLEY SLRVYCLEDT PVALKEVLEL ERTLGGYLVE EPKPLMFKDS
760 770 780 790 800
YHNLRLSLHD LPHAHWRSKL LAKYQEIPFY HIWSGSQKAL HCTFTLERHS
810 820 830 840 850
LASTELTCKI CVRQVEGEGQ IFQLHTTLAE TPAGSLDTLC SAPGSTVTTQ
860 870 880 890 900
LGPYAFKIPL SIRQKICNSL DAPNSRGNDW RMLAQKLSMD RYLNYFATKA
910 920 930 940
SPTGVILDLW EALQQDDGDL NSLASALEEM GKSEMLVAVA TDGDC
Length:945
Mass (Da):103,638
Last modified:October 11, 2004 - v2
Checksum:i56064E335F323447
GO
Isoform 2 (identifier: Q8IZJ1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-367: NKKTLSDPNSHL → M

Show »
Length:934
Mass (Da):102,434
Checksum:i225B3F506D52B780
GO

Sequence cautioni

The sequence BAB14276.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC04382.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti483 – 4831K → E in BAC04382. (PubMed:12975309)Curated
Sequence conflicti851 – 8511L → P in BAB14276. (PubMed:12975309)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421I → V.
Corresponds to variant rs34957097 [ dbSNP | Ensembl ].
VAR_052472
Natural varianti516 – 5161A → T.
Corresponds to variant rs10509332 [ dbSNP | Ensembl ].
VAR_019730

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei356 – 36712NKKTL…PNSHL → M in isoform 2. 1 PublicationVSP_011698Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY126437 mRNA. Translation: AAM95701.1.
AB096256 mRNA. Translation: BAC57998.1.
AY358351 mRNA. Translation: AAQ88717.1.
AK022859 mRNA. Translation: BAB14276.1. Different initiation.
AK094595 mRNA. Translation: BAC04382.1. Different initiation.
AK128132 mRNA. Translation: BAG54634.1.
AL359384, AL359832 Genomic DNA. Translation: CAI16089.1.
AL359384, AL359832 Genomic DNA. Translation: CAI16090.1.
AL359832, AL359384 Genomic DNA. Translation: CAI16737.1.
AL359832, AL359384 Genomic DNA. Translation: CAI16738.1.
CH471083 Genomic DNA. Translation: EAW54420.1.
CH471083 Genomic DNA. Translation: EAW54421.1.
CCDSiCCDS58083.1. [Q8IZJ1-2]
CCDS7309.1. [Q8IZJ1-1]
RefSeqiNP_001231818.1. NM_001244889.1. [Q8IZJ1-2]
NP_734465.2. NM_170744.4. [Q8IZJ1-1]
UniGeneiHs.522997.

Genome annotation databases

EnsembliENST00000335350; ENSP00000334329; ENSG00000107731. [Q8IZJ1-1]
ENST00000373192; ENSP00000362288; ENSG00000107731. [Q8IZJ1-2]
GeneIDi219699.
KEGGihsa:219699.
UCSCiuc001jro.3. human. [Q8IZJ1-1]
uc001jrp.3. human. [Q8IZJ1-2]

Polymorphism databases

DMDMi54036589.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY126437 mRNA. Translation: AAM95701.1 .
AB096256 mRNA. Translation: BAC57998.1 .
AY358351 mRNA. Translation: AAQ88717.1 .
AK022859 mRNA. Translation: BAB14276.1 . Different initiation.
AK094595 mRNA. Translation: BAC04382.1 . Different initiation.
AK128132 mRNA. Translation: BAG54634.1 .
AL359384 , AL359832 Genomic DNA. Translation: CAI16089.1 .
AL359384 , AL359832 Genomic DNA. Translation: CAI16090.1 .
AL359832 , AL359384 Genomic DNA. Translation: CAI16737.1 .
AL359832 , AL359384 Genomic DNA. Translation: CAI16738.1 .
CH471083 Genomic DNA. Translation: EAW54420.1 .
CH471083 Genomic DNA. Translation: EAW54421.1 .
CCDSi CCDS58083.1. [Q8IZJ1-2 ]
CCDS7309.1. [Q8IZJ1-1 ]
RefSeqi NP_001231818.1. NM_001244889.1. [Q8IZJ1-2 ]
NP_734465.2. NM_170744.4. [Q8IZJ1-1 ]
UniGenei Hs.522997.

3D structure databases

ProteinModelPortali Q8IZJ1.
SMRi Q8IZJ1. Positions 48-353, 541-943.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128567. 2 interactions.
DIPi DIP-46275N.
IntActi Q8IZJ1. 2 interactions.
STRINGi 9606.ENSP00000334329.

PTM databases

PhosphoSitei Q8IZJ1.

Polymorphism databases

DMDMi 54036589.

Proteomic databases

MaxQBi Q8IZJ1.
PaxDbi Q8IZJ1.
PRIDEi Q8IZJ1.

Protocols and materials databases

DNASUi 219699.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335350 ; ENSP00000334329 ; ENSG00000107731 . [Q8IZJ1-1 ]
ENST00000373192 ; ENSP00000362288 ; ENSG00000107731 . [Q8IZJ1-2 ]
GeneIDi 219699.
KEGGi hsa:219699.
UCSCi uc001jro.3. human. [Q8IZJ1-1 ]
uc001jrp.3. human. [Q8IZJ1-2 ]

Organism-specific databases

CTDi 219699.
GeneCardsi GC10P072972.
HGNCi HGNC:12568. UNC5B.
HPAi HPA011141.
MIMi 607870. gene.
neXtProti NX_Q8IZJ1.
PharmGKBi PA37205.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293019.
GeneTreei ENSGT00760000119076.
HOGENOMi HOG000060306.
HOVERGENi HBG056483.
InParanoidi Q8IZJ1.
KOi K07521.
OMAi HEVLLQC.
OrthoDBi EOG7BGHJX.
PhylomeDBi Q8IZJ1.
TreeFami TF316767.

Enzyme and pathway databases

Reactomei REACT_22128. Role of DCC in regulating apoptosis.
REACT_22237. Netrin-1 signaling.
REACT_22384. Netrin mediated repulsion signals.

Miscellaneous databases

ChiTaRSi UNC5B. human.
GenomeRNAii 219699.
NextBioi 90721.
PMAP-CutDB Q8IZJ1.
PROi Q8IZJ1.
SOURCEi Search...

Gene expression databases

Bgeei Q8IZJ1.
CleanExi HS_UNC5B.
Genevestigatori Q8IZJ1.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000884. Thrombospondin_1_rpt.
IPR000906. ZU5_dom.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF07679. I-set. 1 hit.
PF00090. TSP_1. 2 hits.
PF00791. ZU5. 1 hit.
[Graphical view ]
SMARTi SM00005. DEATH. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 2 hits.
SM00218. ZU5. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 2 hits.
PS51145. ZU5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2."
    Komatsuzaki K., Dalvin S., Kinane T.B.
    Biochem. Biophys. Res. Commun. 297:898-905(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH GNAI2.
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, MUTAGENESIS OF ASP-412.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala, Teratocarcinoma and Testis.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment."
    Thiebault K., Mazelin L., Pays L., Llambi F., Joly M.-O., Scoazec J.-Y., Saurin J.-C., Romeo G., Mehlen P.
    Proc. Natl. Acad. Sci. U.S.A. 100:4173-4178(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOWN-REGULATION IN CANCER.
  8. "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase."
    Llambi F., Lourenco F.C., Gozuacik D., Guix C., Pays L., Del Rio G., Kimchi A., Mehlen P.
    EMBO J. 24:1192-1201(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DAPK1.
  9. "Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H."
    Maisse C., Rossin A., Cahuzac N., Paradisi A., Klein C., Haillot M.L., Herincs Z., Mehlen P., Hueber A.O.
    Exp. Cell Res. 314:2544-2552(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-403, SUBCELLULAR LOCATION, INTERACTION WITH DAPK1.

Entry informationi

Entry nameiUNC5B_HUMAN
AccessioniPrimary (citable) accession number: Q8IZJ1
Secondary accession number(s): Q5T3R9
, Q5T3S0, Q86SN3, Q8N1Y2, Q9H9F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3