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Q8IZJ1

- UNC5B_HUMAN

UniProt

Q8IZJ1 - UNC5B_HUMAN

Protein

Netrin receptor UNC5B

Gene

UNC5B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei412 – 4132Cleavage; by caspase-3

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. anterior/posterior axon guidance Source: Ensembl
    2. apoptotic process Source: Reactome
    3. axon guidance Source: Reactome
    4. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
    5. negative regulation of neuron apoptotic process Source: UniProtKB
    6. positive regulation of apoptotic process Source: Reactome
    7. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
    8. regulation of apoptotic process Source: Reactome
    9. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_22128. Role of DCC in regulating apoptosis.
    REACT_22237. Netrin-1 signaling.
    REACT_22384. Netrin mediated repulsion signals.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Netrin receptor UNC5B
    Alternative name(s):
    Protein unc-5 homolog 2
    Protein unc-5 homolog B
    p53-regulated receptor for death and life protein 1
    Gene namesi
    Name:UNC5B
    Synonyms:P53RDL1, UNC5H2
    ORF Names:UNQ1883/PRO4326
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:12568. UNC5B.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: Associated with lipid raft.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi412 – 4121D → N: Abolishes cleavage by caspase-3 and subsequent induction of apoptosis. 1 Publication

    Organism-specific databases

    PharmGKBiPA37205.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 945919Netrin receptor UNC5BPRO_0000036071Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi69 ↔ 128By similarity
    Disulfide bondi174 ↔ 225By similarity
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi258 ↔ 295By similarity
    Disulfide bondi262 ↔ 299By similarity
    Disulfide bondi273 ↔ 285By similarity
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Lipidationi403 – 4031S-palmitoyl cysteine1 Publication

    Post-translational modificationi

    Phosphorylated on cytoplasmic tyrosine residues.By similarity
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
    Palmitoylation target the protein to the lipid rafts, and is required for pro-apoptotic activity.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiQ8IZJ1.
    PaxDbiQ8IZJ1.
    PRIDEiQ8IZJ1.

    PTM databases

    PhosphoSiteiQ8IZJ1.

    Miscellaneous databases

    PMAP-CutDBQ8IZJ1.

    Expressioni

    Tissue specificityi

    Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.1 Publication

    Inductioni

    By p53/TP53.

    Gene expression databases

    BgeeiQ8IZJ1.
    CleanExiHS_UNC5B.
    GenevestigatoriQ8IZJ1.

    Organism-specific databases

    HPAiHPA011141.

    Interactioni

    Subunit structurei

    Interacts with the cytoplasmic part of DCC By similarity. Interacts with GNAI2 via its cytoplasmic part. Interacts (via death domain) with DAPK1 (via death domain).By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Agap2Q8CGU49EBI-4409075,EBI-4409108From a different organism.

    Protein-protein interaction databases

    BioGridi128567. 1 interaction.
    DIPiDIP-46275N.
    IntActiQ8IZJ1. 2 interactions.
    STRINGi9606.ENSP00000334329.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZJ1.
    SMRiQ8IZJ1. Positions 48-353, 541-943.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 377351ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini399 – 945547CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 14598Ig-likeAdd
    BLAST
    Domaini147 – 24296Ig-like C2-typeAdd
    BLAST
    Domaini246 – 30055TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini302 – 35453TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini544 – 688145ZU5PROSITE-ProRule annotationAdd
    BLAST
    Domaini865 – 94379DeathAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni689 – 838150UPA domainBy similarityAdd
    BLAST
    Regioni707 – 72519Interaction with DCCBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the unc-5 family.Curated
    Contains 1 death domain.Curated
    Contains 2 TSP type-1 domains.PROSITE-ProRule annotation
    Contains 1 ZU5 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293019.
    HOGENOMiHOG000060306.
    HOVERGENiHBG056483.
    InParanoidiQ8IZJ1.
    KOiK07521.
    OMAiHEVLLQC.
    OrthoDBiEOG7BGHJX.
    PhylomeDBiQ8IZJ1.
    TreeFamiTF316767.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    2.60.40.10. 2 hits.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR000884. Thrombospondin_1_rpt.
    IPR000906. ZU5.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF07679. I-set. 1 hit.
    PF00090. TSP_1. 2 hits.
    PF00791. ZU5. 1 hit.
    [Graphical view]
    SMARTiSM00005. DEATH. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00209. TSP1. 2 hits.
    SM00218. ZU5. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF82895. SSF82895. 2 hits.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS50092. TSP1. 2 hits.
    PS51145. ZU5. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IZJ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGARSGARGA LLLALLLCWD PRLSQAGTDS GSEVLPDSFP SAPAEPLPYF    50
    LQEPQDAYIV KNKPVELRCR AFPATQIYFK CNGEWVSQND HVTQEGLDEA 100
    TGLRVREVQI EVSRQQVEEL FGLEDYWCQC VAWSSAGTTK SRRAYVRIAY 150
    LRKNFDQEPL GKEVPLDHEV LLQCRPPEGV PVAEVEWLKN EDVIDPTQDT 200
    NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT VIVYVNGGWS 250
    SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAF QKTACTTICP 300
    VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD 350
    GLCMQNKKTL SDPNSHLLEA SGDAALYAGL VVAIFVVVAI LMAVGVVVYR 400
    RNCRDFDTDI TDSSAALTGG FHPVNFKTAR PSNPQLLHPS VPPDLTASAG 450
    IYRGPVYALQ DSTDKIPMTN SPLLDPLPSL KVKVYSSSTT GSGPGLADGA 500
    DLLGVLPPGT YPSDFARDTH FLHLRSASLG SQQLLGLPRD PGSSVSGTFG 550
    CLGGRLSIPG TGVSLLVPNG AIPQGKFYEM YLLINKAEST LPLSEGTQTV 600
    LSPSVTCGPT GLLLCRPVIL TMPHCAEVSA RDWIFQLKTQ AHQGHWEEVV 650
    TLDEETLNTP CYCQLEPRAC HILLDQLGTY VFTGESYSRS AVKRLQLAVF 700
    APALCTSLEY SLRVYCLEDT PVALKEVLEL ERTLGGYLVE EPKPLMFKDS 750
    YHNLRLSLHD LPHAHWRSKL LAKYQEIPFY HIWSGSQKAL HCTFTLERHS 800
    LASTELTCKI CVRQVEGEGQ IFQLHTTLAE TPAGSLDTLC SAPGSTVTTQ 850
    LGPYAFKIPL SIRQKICNSL DAPNSRGNDW RMLAQKLSMD RYLNYFATKA 900
    SPTGVILDLW EALQQDDGDL NSLASALEEM GKSEMLVAVA TDGDC 945
    Length:945
    Mass (Da):103,638
    Last modified:October 11, 2004 - v2
    Checksum:i56064E335F323447
    GO
    Isoform 2 (identifier: Q8IZJ1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         356-367: NKKTLSDPNSHL → M

    Show »
    Length:934
    Mass (Da):102,434
    Checksum:i225B3F506D52B780
    GO

    Sequence cautioni

    The sequence BAB14276.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC04382.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti483 – 4831K → E in BAC04382. (PubMed:12975309)Curated
    Sequence conflicti851 – 8511L → P in BAB14276. (PubMed:12975309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti242 – 2421I → V.
    Corresponds to variant rs34957097 [ dbSNP | Ensembl ].
    VAR_052472
    Natural varianti516 – 5161A → T.
    Corresponds to variant rs10509332 [ dbSNP | Ensembl ].
    VAR_019730

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei356 – 36712NKKTL…PNSHL → M in isoform 2. 1 PublicationVSP_011698Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY126437 mRNA. Translation: AAM95701.1.
    AB096256 mRNA. Translation: BAC57998.1.
    AY358351 mRNA. Translation: AAQ88717.1.
    AK022859 mRNA. Translation: BAB14276.1. Different initiation.
    AK094595 mRNA. Translation: BAC04382.1. Different initiation.
    AK128132 mRNA. Translation: BAG54634.1.
    AL359384, AL359832 Genomic DNA. Translation: CAI16089.1.
    AL359384, AL359832 Genomic DNA. Translation: CAI16090.1.
    AL359832, AL359384 Genomic DNA. Translation: CAI16737.1.
    AL359832, AL359384 Genomic DNA. Translation: CAI16738.1.
    CH471083 Genomic DNA. Translation: EAW54420.1.
    CH471083 Genomic DNA. Translation: EAW54421.1.
    CCDSiCCDS58083.1. [Q8IZJ1-2]
    CCDS7309.1. [Q8IZJ1-1]
    RefSeqiNP_001231818.1. NM_001244889.1. [Q8IZJ1-2]
    NP_734465.2. NM_170744.4. [Q8IZJ1-1]
    UniGeneiHs.522997.

    Genome annotation databases

    EnsembliENST00000335350; ENSP00000334329; ENSG00000107731. [Q8IZJ1-1]
    ENST00000373192; ENSP00000362288; ENSG00000107731. [Q8IZJ1-2]
    GeneIDi219699.
    KEGGihsa:219699.
    UCSCiuc001jro.3. human. [Q8IZJ1-1]
    uc001jrp.3. human. [Q8IZJ1-2]

    Polymorphism databases

    DMDMi54036589.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY126437 mRNA. Translation: AAM95701.1 .
    AB096256 mRNA. Translation: BAC57998.1 .
    AY358351 mRNA. Translation: AAQ88717.1 .
    AK022859 mRNA. Translation: BAB14276.1 . Different initiation.
    AK094595 mRNA. Translation: BAC04382.1 . Different initiation.
    AK128132 mRNA. Translation: BAG54634.1 .
    AL359384 , AL359832 Genomic DNA. Translation: CAI16089.1 .
    AL359384 , AL359832 Genomic DNA. Translation: CAI16090.1 .
    AL359832 , AL359384 Genomic DNA. Translation: CAI16737.1 .
    AL359832 , AL359384 Genomic DNA. Translation: CAI16738.1 .
    CH471083 Genomic DNA. Translation: EAW54420.1 .
    CH471083 Genomic DNA. Translation: EAW54421.1 .
    CCDSi CCDS58083.1. [Q8IZJ1-2 ]
    CCDS7309.1. [Q8IZJ1-1 ]
    RefSeqi NP_001231818.1. NM_001244889.1. [Q8IZJ1-2 ]
    NP_734465.2. NM_170744.4. [Q8IZJ1-1 ]
    UniGenei Hs.522997.

    3D structure databases

    ProteinModelPortali Q8IZJ1.
    SMRi Q8IZJ1. Positions 48-353, 541-943.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128567. 1 interaction.
    DIPi DIP-46275N.
    IntActi Q8IZJ1. 2 interactions.
    STRINGi 9606.ENSP00000334329.

    PTM databases

    PhosphoSitei Q8IZJ1.

    Polymorphism databases

    DMDMi 54036589.

    Proteomic databases

    MaxQBi Q8IZJ1.
    PaxDbi Q8IZJ1.
    PRIDEi Q8IZJ1.

    Protocols and materials databases

    DNASUi 219699.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335350 ; ENSP00000334329 ; ENSG00000107731 . [Q8IZJ1-1 ]
    ENST00000373192 ; ENSP00000362288 ; ENSG00000107731 . [Q8IZJ1-2 ]
    GeneIDi 219699.
    KEGGi hsa:219699.
    UCSCi uc001jro.3. human. [Q8IZJ1-1 ]
    uc001jrp.3. human. [Q8IZJ1-2 ]

    Organism-specific databases

    CTDi 219699.
    GeneCardsi GC10P072972.
    HGNCi HGNC:12568. UNC5B.
    HPAi HPA011141.
    MIMi 607870. gene.
    neXtProti NX_Q8IZJ1.
    PharmGKBi PA37205.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293019.
    HOGENOMi HOG000060306.
    HOVERGENi HBG056483.
    InParanoidi Q8IZJ1.
    KOi K07521.
    OMAi HEVLLQC.
    OrthoDBi EOG7BGHJX.
    PhylomeDBi Q8IZJ1.
    TreeFami TF316767.

    Enzyme and pathway databases

    Reactomei REACT_22128. Role of DCC in regulating apoptosis.
    REACT_22237. Netrin-1 signaling.
    REACT_22384. Netrin mediated repulsion signals.

    Miscellaneous databases

    ChiTaRSi UNC5B. human.
    GenomeRNAii 219699.
    NextBioi 90721.
    PMAP-CutDB Q8IZJ1.
    PROi Q8IZJ1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IZJ1.
    CleanExi HS_UNC5B.
    Genevestigatori Q8IZJ1.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    2.60.40.10. 2 hits.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR000884. Thrombospondin_1_rpt.
    IPR000906. ZU5.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF07679. I-set. 1 hit.
    PF00090. TSP_1. 2 hits.
    PF00791. ZU5. 1 hit.
    [Graphical view ]
    SMARTi SM00005. DEATH. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00209. TSP1. 2 hits.
    SM00218. ZU5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF82895. SSF82895. 2 hits.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS50092. TSP1. 2 hits.
    PS51145. ZU5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2."
      Komatsuzaki K., Dalvin S., Kinane T.B.
      Biochem. Biophys. Res. Commun. 297:898-905(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH GNAI2.
      Tissue: Lung.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, MUTAGENESIS OF ASP-412.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala, Teratocarcinoma and Testis.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment."
      Thiebault K., Mazelin L., Pays L., Llambi F., Joly M.-O., Scoazec J.-Y., Saurin J.-C., Romeo G., Mehlen P.
      Proc. Natl. Acad. Sci. U.S.A. 100:4173-4178(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOWN-REGULATION IN CANCER.
    8. "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase."
      Llambi F., Lourenco F.C., Gozuacik D., Guix C., Pays L., Del Rio G., Kimchi A., Mehlen P.
      EMBO J. 24:1192-1201(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DAPK1.
    9. "Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H."
      Maisse C., Rossin A., Cahuzac N., Paradisi A., Klein C., Haillot M.L., Herincs Z., Mehlen P., Hueber A.O.
      Exp. Cell Res. 314:2544-2552(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-403, SUBCELLULAR LOCATION, INTERACTION WITH DAPK1.

    Entry informationi

    Entry nameiUNC5B_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZJ1
    Secondary accession number(s): Q5T3R9
    , Q5T3S0, Q86SN3, Q8N1Y2, Q9H9F3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3