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Protein

Interferon lambda-2

Gene

IFNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

SignaLinkiQ8IZJ0.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-2
Short name:
IFN-lambda-2
Alternative name(s):
Cytokine Zcyto20
Interleukin-28A
Short name:
IL-28A
Gene namesi
Name:IFNL2
Synonyms:IL28A, ZCYTO20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18364. IFNL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934396.

Polymorphism and mutation databases

BioMutaiIFNL2.
DMDMi55976531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 200175Interferon lambda-2PRO_0000015509Add
BLAST

Proteomic databases

PaxDbiQ8IZJ0.
PRIDEiQ8IZJ0.

PTM databases

PhosphoSiteiQ8IZJ0.

Expressioni

Inductioni

By viral infections or double-stranded RNA.2 Publications

Gene expression databases

BgeeiQ8IZJ0.
CleanExiHS_IL28A.
GenevisibleiQ8IZJ0. HS.

Organism-specific databases

HPAiCAB025489.

Interactioni

Protein-protein interaction databases

BioGridi129394. 1 interaction.
STRINGi9606.ENSP00000333639.

Structurei

3D structure databases

ProteinModelPortaliQ8IZJ0.
SMRiQ8IZJ0. Positions 41-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40189.
GeneTreeiENSGT00390000014310.
HOGENOMiHOG000232074.
HOVERGENiHBG052108.
InParanoidiQ8IZJ0.
KOiK05447.
OMAiRTWDLQQ.
OrthoDBiEOG7F24V6.
PhylomeDBiQ8IZJ0.
TreeFamiTF336172.

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLDMTGDCT PVLVLMAAVL TVTGAVPVAR LHGALPDARG CHIAQFKSLS
60 70 80 90 100
PQELQAFKRA KDALEESLLL KDCRCHSRLF PRTWDLRQLQ VRERPMALEA
110 120 130 140 150
ELALTLKVLE ATADTDPALV DVLDQPLHTL HHILSQFRAC IQPQPTAGPR
160 170 180 190 200
TRGRLHHWLY RLQEAPKKES PGCLEASVTF NLFRLLTRDL NCVASGDLCV
Length:200
Mass (Da):22,288
Last modified:March 1, 2003 - v1
Checksum:iDFC7B49F31BF488E
GO

Sequence cautioni

The sequence AAR24510.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511T → A in AAN86126 (PubMed:12483210).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101T → M.
Corresponds to variant rs554971 [ dbSNP | Ensembl ].
VAR_053384
Natural varianti112 – 1121T → A.
Corresponds to variant rs8103362 [ dbSNP | Ensembl ].
VAR_053385

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129148 mRNA. Translation: AAN28263.1.
DQ126336 Genomic DNA. Translation: AAZ38827.1.
DQ126337 mRNA. Translation: AAZ38828.1.
BC113581 mRNA. Translation: AAI13582.1.
BC113583 mRNA. Translation: AAI13584.1.
AY184373 mRNA. Translation: AAN86126.1.
AY336715 mRNA. Translation: AAR24510.1. Different initiation.
CCDSiCCDS42567.1.
RefSeqiNP_742150.1. NM_172138.1.
XP_011525058.1. XM_011526756.1.
UniGeneiHs.567792.

Genome annotation databases

EnsembliENST00000331982; ENSP00000333639; ENSG00000183709.
GeneIDi282616.
KEGGihsa:282616.
UCSCiuc002oku.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-28 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129148 mRNA. Translation: AAN28263.1.
DQ126336 Genomic DNA. Translation: AAZ38827.1.
DQ126337 mRNA. Translation: AAZ38828.1.
BC113581 mRNA. Translation: AAI13582.1.
BC113583 mRNA. Translation: AAI13584.1.
AY184373 mRNA. Translation: AAN86126.1.
AY336715 mRNA. Translation: AAR24510.1. Different initiation.
CCDSiCCDS42567.1.
RefSeqiNP_742150.1. NM_172138.1.
XP_011525058.1. XM_011526756.1.
UniGeneiHs.567792.

3D structure databases

ProteinModelPortaliQ8IZJ0.
SMRiQ8IZJ0. Positions 41-200.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129394. 1 interaction.
STRINGi9606.ENSP00000333639.

PTM databases

PhosphoSiteiQ8IZJ0.

Polymorphism and mutation databases

BioMutaiIFNL2.
DMDMi55976531.

Proteomic databases

PaxDbiQ8IZJ0.
PRIDEiQ8IZJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331982; ENSP00000333639; ENSG00000183709.
GeneIDi282616.
KEGGihsa:282616.
UCSCiuc002oku.1. human.

Organism-specific databases

CTDi282616.
GeneCardsiGC19P039760.
HGNCiHGNC:18364. IFNL2.
HPAiCAB025489.
MIMi607401. gene.
neXtProtiNX_Q8IZJ0.
PharmGKBiPA134934396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40189.
GeneTreeiENSGT00390000014310.
HOGENOMiHOG000232074.
HOVERGENiHBG052108.
InParanoidiQ8IZJ0.
KOiK05447.
OMAiRTWDLQQ.
OrthoDBiEOG7F24V6.
PhylomeDBiQ8IZJ0.
TreeFamiTF336172.

Enzyme and pathway databases

SignaLinkiQ8IZJ0.

Miscellaneous databases

GenomeRNAii282616.
NextBioi93466.
PROiQ8IZJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IZJ0.
CleanExiHS_IL28A.
GenevisibleiQ8IZJ0. HS.

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
  2. "Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication."
    Zhu H., Butera M., Nelson D., Liu C.
    Virol. J. 2:80-80(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
    Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
    Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-200, FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
  5. "Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells."
    Li M.C., Wang H.Y., Wang H.Y., Li T., He S.H.
    Acta Pharmacol. Sin. 27:453-459(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-200, FUNCTION.
    Tissue: Peripheral blood leukocyte.
  6. "Interferon-lambda: a new addition to an old family."
    Donnelly R.P., Kotenko S.V.
    J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
    Hermant P., Michiels T.
    J. Innate Immun. 6:563-574(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiIFNL2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZJ0
Secondary accession number(s): Q45KQ8, Q6VN55, Q8IWL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.