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Q8IZJ0

- IFNL2_HUMAN

UniProt

Q8IZJ0 - IFNL2_HUMAN

Protein

Interferon lambda-2

Gene

IFNL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.3 Publications

    GO - Biological processi

    1. defense response to virus Source: UniProtKB
    2. JAK-STAT cascade Source: InterPro
    3. mucosal immune response Source: UniProtKB
    4. positive regulation of immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    SignaLinkiQ8IZJ0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon lambda-2
    Short name:
    IFN-lambda-2
    Alternative name(s):
    Cytokine Zcyto20
    Interleukin-28A
    Short name:
    IL-28A
    Gene namesi
    Name:IFNL2
    Synonyms:IL28A, ZCYTO20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:18364. IFNL2.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134934396.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 200175Interferon lambda-2PRO_0000015509Add
    BLAST

    Proteomic databases

    PaxDbiQ8IZJ0.
    PRIDEiQ8IZJ0.

    PTM databases

    PhosphoSiteiQ8IZJ0.

    Expressioni

    Inductioni

    By viral infections or double-stranded RNA.2 Publications

    Gene expression databases

    ArrayExpressiQ8IZJ0.
    BgeeiQ8IZJ0.
    CleanExiHS_IL28A.
    GenevestigatoriQ8IZJ0.

    Organism-specific databases

    HPAiCAB025489.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000333639.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZJ0.
    SMRiQ8IZJ0. Positions 41-200.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the lambda interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40189.
    HOGENOMiHOG000232074.
    HOVERGENiHBG052108.
    InParanoidiQ8IZJ0.
    KOiK05447.
    OMAiAWERPVA.
    OrthoDBiEOG7F24V6.
    PhylomeDBiQ8IZJ0.
    TreeFamiTF336172.

    Family and domain databases

    InterProiIPR029177. INF_lambda.
    [Graphical view]
    PfamiPF15177. IL28A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8IZJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLDMTGDCT PVLVLMAAVL TVTGAVPVAR LHGALPDARG CHIAQFKSLS    50
    PQELQAFKRA KDALEESLLL KDCRCHSRLF PRTWDLRQLQ VRERPMALEA 100
    ELALTLKVLE ATADTDPALV DVLDQPLHTL HHILSQFRAC IQPQPTAGPR 150
    TRGRLHHWLY RLQEAPKKES PGCLEASVTF NLFRLLTRDL NCVASGDLCV 200
    Length:200
    Mass (Da):22,288
    Last modified:March 1, 2003 - v1
    Checksum:iDFC7B49F31BF488E
    GO

    Sequence cautioni

    The sequence AAR24510.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511T → A in AAN86126. (PubMed:12483210)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101T → M.
    Corresponds to variant rs554971 [ dbSNP | Ensembl ].
    VAR_053384
    Natural varianti112 – 1121T → A.
    Corresponds to variant rs8103362 [ dbSNP | Ensembl ].
    VAR_053385

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY129148 mRNA. Translation: AAN28263.1.
    DQ126336 Genomic DNA. Translation: AAZ38827.1.
    DQ126337 mRNA. Translation: AAZ38828.1.
    BC113581 mRNA. Translation: AAI13582.1.
    BC113583 mRNA. Translation: AAI13584.1.
    AY184373 mRNA. Translation: AAN86126.1.
    AY336715 mRNA. Translation: AAR24510.1. Different initiation.
    CCDSiCCDS42567.1.
    RefSeqiNP_742150.1. NM_172138.1.
    UniGeneiHs.567792.

    Genome annotation databases

    EnsembliENST00000331982; ENSP00000333639; ENSG00000183709.
    GeneIDi282616.
    KEGGihsa:282616.
    UCSCiuc002oku.1. human.

    Polymorphism databases

    DMDMi55976531.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-28 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY129148 mRNA. Translation: AAN28263.1 .
    DQ126336 Genomic DNA. Translation: AAZ38827.1 .
    DQ126337 mRNA. Translation: AAZ38828.1 .
    BC113581 mRNA. Translation: AAI13582.1 .
    BC113583 mRNA. Translation: AAI13584.1 .
    AY184373 mRNA. Translation: AAN86126.1 .
    AY336715 mRNA. Translation: AAR24510.1 . Different initiation.
    CCDSi CCDS42567.1.
    RefSeqi NP_742150.1. NM_172138.1.
    UniGenei Hs.567792.

    3D structure databases

    ProteinModelPortali Q8IZJ0.
    SMRi Q8IZJ0. Positions 41-200.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000333639.

    PTM databases

    PhosphoSitei Q8IZJ0.

    Polymorphism databases

    DMDMi 55976531.

    Proteomic databases

    PaxDbi Q8IZJ0.
    PRIDEi Q8IZJ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331982 ; ENSP00000333639 ; ENSG00000183709 .
    GeneIDi 282616.
    KEGGi hsa:282616.
    UCSCi uc002oku.1. human.

    Organism-specific databases

    CTDi 282616.
    GeneCardsi GC19P039760.
    HGNCi HGNC:18364. IFNL2.
    HPAi CAB025489.
    MIMi 607401. gene.
    neXtProti NX_Q8IZJ0.
    PharmGKBi PA134934396.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40189.
    HOGENOMi HOG000232074.
    HOVERGENi HBG052108.
    InParanoidi Q8IZJ0.
    KOi K05447.
    OMAi AWERPVA.
    OrthoDBi EOG7F24V6.
    PhylomeDBi Q8IZJ0.
    TreeFami TF336172.

    Enzyme and pathway databases

    SignaLinki Q8IZJ0.

    Miscellaneous databases

    GenomeRNAii 282616.
    NextBioi 93466.
    PROi Q8IZJ0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IZJ0.
    Bgeei Q8IZJ0.
    CleanExi HS_IL28A.
    Genevestigatori Q8IZJ0.

    Family and domain databases

    InterProi IPR029177. INF_lambda.
    [Graphical view ]
    Pfami PF15177. IL28A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
    2. "Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication."
      Zhu H., Butera M., Nelson D., Liu C.
      Virol. J. 2:80-80(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
      Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
      Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-200, FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
    5. "Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells."
      Li M.C., Wang H.Y., Wang H.Y., Li T., He S.H.
      Acta Pharmacol. Sin. 27:453-459(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-200, FUNCTION.
      Tissue: Peripheral blood leukocyte.
    6. "Interferon-lambda: a new addition to an old family."
      Donnelly R.P., Kotenko S.V.
      J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. "Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
      Hermant P., Michiels T.
      J. Innate Immun. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiIFNL2_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZJ0
    Secondary accession number(s): Q45KQ8, Q6VN55, Q8IWL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-5 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3