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Protein

Interferon lambda-2

Gene

IFNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

BioCyciZFISH:G66-33003-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiQ8IZJ0.
SIGNORiQ8IZJ0.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-2
Short name:
IFN-lambda-2
Alternative name(s):
Cytokine Zcyto20
Interleukin-28A
Short name:
IL-28A
Gene namesi
Name:IFNL2
Synonyms:IL28A, ZCYTO20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18364. IFNL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi282616.
OpenTargetsiENSG00000183709.
PharmGKBiPA134934396.

Polymorphism and mutation databases

BioMutaiIFNL2.
DMDMi55976531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001550926 – 200Interferon lambda-2Add BLAST175

Proteomic databases

PaxDbiQ8IZJ0.
PeptideAtlasiQ8IZJ0.
PRIDEiQ8IZJ0.

PTM databases

iPTMnetiQ8IZJ0.
PhosphoSitePlusiQ8IZJ0.

Expressioni

Inductioni

By viral infections or double-stranded RNA.2 Publications

Gene expression databases

BgeeiENSG00000183709.
CleanExiHS_IL28A.
GenevisibleiQ8IZJ0. HS.

Organism-specific databases

HPAiCAB025489.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129394. 1 interactor.
STRINGi9606.ENSP00000333639.

Structurei

3D structure databases

ProteinModelPortaliQ8IZJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0IH. Eukaryota.
ENOG410ZDRD. LUCA.
GeneTreeiENSGT00390000014310.
HOGENOMiHOG000232074.
HOVERGENiHBG052108.
InParanoidiQ8IZJ0.
KOiK05447.
OMAiRTWDLQQ.
OrthoDBiEOG091G0RUH.
PhylomeDBiQ8IZJ0.
TreeFamiTF336172.

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLDMTGDCT PVLVLMAAVL TVTGAVPVAR LHGALPDARG CHIAQFKSLS
60 70 80 90 100
PQELQAFKRA KDALEESLLL KDCRCHSRLF PRTWDLRQLQ VRERPMALEA
110 120 130 140 150
ELALTLKVLE ATADTDPALV DVLDQPLHTL HHILSQFRAC IQPQPTAGPR
160 170 180 190 200
TRGRLHHWLY RLQEAPKKES PGCLEASVTF NLFRLLTRDL NCVASGDLCV
Length:200
Mass (Da):22,288
Last modified:March 1, 2003 - v1
Checksum:iDFC7B49F31BF488E
GO

Sequence cautioni

The sequence AAR24510 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151T → A in AAN86126 (PubMed:12483210).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05338410T → M.Corresponds to variant rs554971dbSNPEnsembl.1
Natural variantiVAR_053385112T → A.Corresponds to variant rs8103362dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129148 mRNA. Translation: AAN28263.1.
DQ126336 Genomic DNA. Translation: AAZ38827.1.
DQ126337 mRNA. Translation: AAZ38828.1.
BC113581 mRNA. Translation: AAI13582.1.
BC113583 mRNA. Translation: AAI13584.1.
AY184373 mRNA. Translation: AAN86126.1.
AY336715 mRNA. Translation: AAR24510.1. Different initiation.
CCDSiCCDS42567.1.
RefSeqiNP_742150.1. NM_172138.1.
UniGeneiHs.567792.

Genome annotation databases

EnsembliENST00000331982; ENSP00000333639; ENSG00000183709.
GeneIDi282616.
KEGGihsa:282616.
UCSCiuc002oku.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-28 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129148 mRNA. Translation: AAN28263.1.
DQ126336 Genomic DNA. Translation: AAZ38827.1.
DQ126337 mRNA. Translation: AAZ38828.1.
BC113581 mRNA. Translation: AAI13582.1.
BC113583 mRNA. Translation: AAI13584.1.
AY184373 mRNA. Translation: AAN86126.1.
AY336715 mRNA. Translation: AAR24510.1. Different initiation.
CCDSiCCDS42567.1.
RefSeqiNP_742150.1. NM_172138.1.
UniGeneiHs.567792.

3D structure databases

ProteinModelPortaliQ8IZJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129394. 1 interactor.
STRINGi9606.ENSP00000333639.

PTM databases

iPTMnetiQ8IZJ0.
PhosphoSitePlusiQ8IZJ0.

Polymorphism and mutation databases

BioMutaiIFNL2.
DMDMi55976531.

Proteomic databases

PaxDbiQ8IZJ0.
PeptideAtlasiQ8IZJ0.
PRIDEiQ8IZJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331982; ENSP00000333639; ENSG00000183709.
GeneIDi282616.
KEGGihsa:282616.
UCSCiuc002oku.2. human.

Organism-specific databases

CTDi282616.
DisGeNETi282616.
GeneCardsiIFNL2.
HGNCiHGNC:18364. IFNL2.
HPAiCAB025489.
MIMi607401. gene.
neXtProtiNX_Q8IZJ0.
OpenTargetsiENSG00000183709.
PharmGKBiPA134934396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0IH. Eukaryota.
ENOG410ZDRD. LUCA.
GeneTreeiENSGT00390000014310.
HOGENOMiHOG000232074.
HOVERGENiHBG052108.
InParanoidiQ8IZJ0.
KOiK05447.
OMAiRTWDLQQ.
OrthoDBiEOG091G0RUH.
PhylomeDBiQ8IZJ0.
TreeFamiTF336172.

Enzyme and pathway databases

BioCyciZFISH:G66-33003-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiQ8IZJ0.
SIGNORiQ8IZJ0.

Miscellaneous databases

GenomeRNAii282616.
PROiQ8IZJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183709.
CleanExiHS_IL28A.
GenevisibleiQ8IZJ0. HS.

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFNL2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZJ0
Secondary accession number(s): Q45KQ8, Q6VN55, Q8IWL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.