Reviewed, UniProtKB/Swiss-Prot Q8IZH2 (XRN1_HUMAN)

Names and origin

Protein names

Recommended name:
    5'-3' exoribonuclease 1
    EC=3.1.11.-
Alternative name(s):
    Strand-exchange protein 1 homolog

Gene names

Name:	XRN1
Synonyms:	SEP1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1706 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA By similarity. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
Subunit structure	Associates with alpha and beta tubulins By similarity. Found in a mRNP complex with RENT1, RENT2, RENT3B and XRN1.
Subcellular location	Cytoplasm. Note: Discrete foci at the inner surface of the cell membrane. Ref.1 Ref.5 Ref.7
Tissue specificity	Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. Ref.8
Induction	By GDNF. Ref.1
Miscellaneous	Down-regulated in OGS biopsy.
Sequence similarities	Belongs to the 5'-3' exonuclease family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Tumor suppressor
Ligand	DNA-binding RNA-binding
Molecular function	Exonuclease Hydrolase Nuclease
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell cycle Inferred from electronic annotation. Source: UniProtKB-KW nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-3' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ALDOA	P04075	1	EBI-372406,EBI-709613
AP1G2	O75843	1	EBI-372406,EBI-373637
BAT3	P46379	1	EBI-372406,EBI-347552
CCT5	P48643	1	EBI-372406,EBI-355710
CHD4	Q14839	1	EBI-372406,EBI-372916
DPP7	Q9UHL4	1	EBI-372406,EBI-372284
HEATR1	Q9H583	1	EBI-372406,EBI-1048716
HNRNPA1	P09651	1	EBI-372406,EBI-352662
LDHA	P00338	1	EBI-372406,EBI-372327
MGC16385	Q9BSD4	1	EBI-372406,EBI-372206
NDUFA13	Q9P0J0	1	EBI-372406,EBI-372742
PABPC4	Q13310	1	EBI-372406,EBI-372844
SMARCD2	Q92925	1	EBI-372406,EBI-358441
SPATA20	Q8TB22	1	EBI-372406,EBI-372221
STAM2	O75886	1	EBI-372406,EBI-373258
VWA5B2	Q8N398	1	EBI-372406,EBI-1785414
WAPAL	Q7Z5K2	1	EBI-372406,EBI-1022242

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZH2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZH2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1354: M → MK
     1540-1552: Missing.

Isoform 3 (identifier: Q8IZH2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     449-459: DDFLADQAACY → EYVFANAFILK
     460-1706: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1706	1706	5'-3' exoribonuclease 1		PRO_0000071392
Amino acid modifications
	Modified residue	1173	1	Phosphoserine Ref.9
	Modified residue	1176	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	449 – 459	11	DDFLADQAACY → EYVFANAFILK in isoform 3.		VSP_016692
	Alternative sequence	460 – 1706	1247	Missing in isoform 3.		VSP_016693
	Alternative sequence	1354	1	M → MK in isoform 2.		VSP_016694
	Alternative sequence	1540 – 1552	13	Missing in isoform 2.		VSP_016695
	Natural variant	674	1	S → G: dbSNP rs35214510.		VAR_053000
	Natural variant	1259	1	V → A: dbSNP rs35902661.		VAR_053001
Experimental info
	Sequence conflict	48	1	D → G in CAE45950. Ref.2
	Sequence conflict	55	1	I → T in BAC04718. Ref.4
	Sequence conflict	113	1	K → E in CAH18332. Ref.2
	Sequence conflict	142	1	R → K in AAH48104. Ref.3
	Sequence conflict	148	1	K → E in CAH18332. Ref.2
	Sequence conflict	572	1	Missing in CAB63749. Ref.2
	Sequence conflict	722	1	L → I in CAE45950. Ref.2
	Sequence conflict	834	1	K → R in CAH18332. Ref.2
	Sequence conflict	1250	1	Q → R in CAH18332. Ref.2
	Sequence conflict	1463	1	L → F in CAE45950. Ref.2
	Sequence conflict	1686	1	S → P in CAH18332. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D06A76208DE78698	FASTA	1,706	194,107
	10 20 30 40 50 60 MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI 70 80 90 100 110 120 FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE 130 140 150 160 170 180 TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK 190 200 210 220 230 240 IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA 250 260 270 280 290 300 PEETTFHLLH LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL 310 320 330 340 350 360 HINHDALPLL YGTYVTILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW 370 380 390 400 410 420 FESKVGNKYL NEAAGVAAEE ARNYKEKKKL KGQENSLCWT ALDKNEGEMI TSKDNLEDET 430 440 450 460 470 480 EDDDLFETEF RQYKRTYYMT KMGVDVVSDD FLADQAACYV QAIQWILHYY YHGVQSWSWY 490 500 510 520 530 540 YPYHYAPFLS DIHNISTLKI HFELGKPFKP FEQLLAVLPA ASKNLLPACY QHLMTNEDSP 550 560 570 580 590 600 IIEYYPPDFK TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKKEER KRNQHSECLM 610 620 630 640 650 660 CWYDRDTEFI YPSPWPEKFP AIERCCTRYK IISLDAWRVD INKNKITRID QKALYFCGFP 670 680 690 700 710 720 TLKHIRHKFF LKKSGVQVFQ QSSRGENMML EILVDAESDE LTVENVASSV LGKSVFVNWP 730 740 750 760 770 780 HLEEARVVAV SDGETKFYLE EPPGTQKLYS GRTAPPSKVV HLGDKEQSNW AKEVQGISEH 790 800 810 820 830 840 YLRRKGIIIN ETSAVVYAQL LTGRKYQINQ NGEVRLEKQW SKQVVPFVYQ TIVKDIRAFD 850 860 870 880 890 900 SRFSNIKTLD DLFPLRSMVF MLGTPYYGCT GEVQDSGDVI TEGRIRVIFS IPCEPNLDAL 910 920 930 940 950 960 IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN 970 980 990 1000 1010 1020 KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY IAKNSQEDVF YEDDIWPGEN 1030 1040 1050 1060 1070 1080 ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV 1090 1100 1110 1120 1130 1140 KPHLLYRPLE QQHGVIPDRD AEFCLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF 1150 1160 1170 1180 1190 1200 EVLFDEEFPG GLTIRCSPGR GYRLPTSALV NLSHGSRSET GNQKLTAIVK PQPAVHQHSS 1210 1220 1230 1240 1250 1260 SSSVSSGHLG ALNHSPQSLF VPTQVPTKDD DEFCNIWQSL QGSGKMQYFQ PTIQEKGAVL 1270 1280 1290 1300 1310 1320 PQEISQVNQH HKSGFNDNSV KYQQRKHDPH RKFKEECKSP KAECWSQKMS NKQPNSGIEN 1330 1340 1350 1360 1370 1380 FLASLNISKE NEVQSSHHGE PPSEEHLSPQ SFAMGTRMLK EILKIDGSNT VDHKNEIKQI 1390 1400 1410 1420 1430 1440 ANEIPVSSNR RDEYGLPSQP KQNKKLASYM NKPHSANEYH NVQSMDNMCW PAPSQIPPVS 1450 1460 1470 1480 1490 1500 TPVTELSRIC SLVGMPQPDF SFLRMPQTMT VCQVKLSNGL LVHGPQCHSE NEAKEKAALF 1510 1520 1530 1540 1550 1560 ALQQLGSLGM NFPLPSQVFA NYPSAVPPGT IPPAFPPPTG WDHYGSNYAL GAANIMPSSS 1570 1580 1590 1600 1610 1620 HLFGSMPWGP SVPVPGKPFH HTLYSGTMPM AGGIPGGVHN QFIPLQVTKK RVANKKNFEN 1630 1640 1650 1660 1670 1680 KEAQSSQATP VQTSQPDSSN IVKVSPRESS SASLKSSPIA QPASSFQVET ASQGHSISHH 1690 1700 KSTPISSSRR KSRKLAVNFG VSKPSE
	Isoform 2. Checksum: 25AD7CD0191A4E05	FASTA	1,694	192,843
	10 20 30 40 50 60 MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI 70 80 90 100 110 120 FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE 130 140 150 160 170 180 TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK 190 200 210 220 230 240 IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA 250 260 270 280 290 300 PEETTFHLLH LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL 310 320 330 340 350 360 HINHDALPLL YGTYVTILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW 370 380 390 400 410 420 FESKVGNKYL NEAAGVAAEE ARNYKEKKKL KGQENSLCWT ALDKNEGEMI TSKDNLEDET 430 440 450 460 470 480 EDDDLFETEF RQYKRTYYMT KMGVDVVSDD FLADQAACYV QAIQWILHYY YHGVQSWSWY 490 500 510 520 530 540 YPYHYAPFLS DIHNISTLKI HFELGKPFKP FEQLLAVLPA ASKNLLPACY QHLMTNEDSP 550 560 570 580 590 600 IIEYYPPDFK TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKKEER KRNQHSECLM 610 620 630 640 650 660 CWYDRDTEFI YPSPWPEKFP AIERCCTRYK IISLDAWRVD INKNKITRID QKALYFCGFP 670 680 690 700 710 720 TLKHIRHKFF LKKSGVQVFQ QSSRGENMML EILVDAESDE LTVENVASSV LGKSVFVNWP 730 740 750 760 770 780 HLEEARVVAV SDGETKFYLE EPPGTQKLYS GRTAPPSKVV HLGDKEQSNW AKEVQGISEH 790 800 810 820 830 840 YLRRKGIIIN ETSAVVYAQL LTGRKYQINQ NGEVRLEKQW SKQVVPFVYQ TIVKDIRAFD 850 860 870 880 890 900 SRFSNIKTLD DLFPLRSMVF MLGTPYYGCT GEVQDSGDVI TEGRIRVIFS IPCEPNLDAL 910 920 930 940 950 960 IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN 970 980 990 1000 1010 1020 KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY IAKNSQEDVF YEDDIWPGEN 1030 1040 1050 1060 1070 1080 ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV 1090 1100 1110 1120 1130 1140 KPHLLYRPLE QQHGVIPDRD AEFCLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF 1150 1160 1170 1180 1190 1200 EVLFDEEFPG GLTIRCSPGR GYRLPTSALV NLSHGSRSET GNQKLTAIVK PQPAVHQHSS 1210 1220 1230 1240 1250 1260 SSSVSSGHLG ALNHSPQSLF VPTQVPTKDD DEFCNIWQSL QGSGKMQYFQ PTIQEKGAVL 1270 1280 1290 1300 1310 1320 PQEISQVNQH HKSGFNDNSV KYQQRKHDPH RKFKEECKSP KAECWSQKMS NKQPNSGIEN 1330 1340 1350 1360 1370 1380 FLASLNISKE NEVQSSHHGE PPSEEHLSPQ SFAMKGTRML KEILKIDGSN TVDHKNEIKQ 1390 1400 1410 1420 1430 1440 IANEIPVSSN RRDEYGLPSQ PKQNKKLASY MNKPHSANEY HNVQSMDNMC WPAPSQIPPV 1450 1460 1470 1480 1490 1500 STPVTELSRI CSLVGMPQPD FSFLRMPQTM TVCQVKLSNG LLVHGPQCHS ENEAKEKAAL 1510 1520 1530 1540 1550 1560 FALQQLGSLG MNFPLPSQVF ANYPSAVPPG TIPPAFPPPT ANIMPSSSHL FGSMPWGPSV 1570 1580 1590 1600 1610 1620 PVPGKPFHHT LYSGTMPMAG GIPGGVHNQF IPLQVTKKRV ANKKNFENKE AQSSQATPVQ 1630 1640 1650 1660 1670 1680 TSQPDSSNIV KVSPRESSSA SLKSSPIAQP ASSFQVETAS QGHSISHHKS TPISSSRRKS 1690 RKLAVNFGVS KPSE
	Isoform 3. Checksum: 2C546FA5EDB81BC3	FASTA	459	53,818
	10 20 30 40 50 60 MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI 70 80 90 100 110 120 FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE 130 140 150 160 170 180 TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK 190 200 210 220 230 240 IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA 250 260 270 280 290 300 PEETTFHLLH LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL 310 320 330 340 350 360 HINHDALPLL YGTYVTILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW 370 380 390 400 410 420 FESKVGNKYL NEAAGVAAEE ARNYKEKKKL KGQENSLCWT ALDKNEGEMI TSKDNLEDET 430 440 450 EDDDLFETEF RQYKRTYYMT KMGVDVVSEY VFANAFILK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system." Shimoyama Y., Morikawa Y., Ichihara M., Kodama Y., Fukuda N., Hayashi H., Morinaga T., Iwashita T., Murakumo Y., Takahashi M. Neuroscience 121:899-906(2003) [PubMed: 14580940] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, SUBCELLULAR LOCATION. Tissue: Neuroblastoma.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Fetal kidney, Small intestine and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain and Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-473 (ISOFORMS 1/2). Tissue: Mesangial cell.
[5]	"Cloning and characterization of human Sep1 (hSEP1) gene and cytoplasmic localization of its product." Sato Y., Shimamoto A., Shobuike T., Sugimoto M., Ikeda H., Kuroda S., Furuichi Y. DNA Res. 5:241-246(1998) [PubMed: 9802570] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 2), SUBCELLULAR LOCATION.
[6]	"Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities." Lejeune F., Li X., Maquat L.E. Mol. Cell 12:675-687(2003) [PubMed: 14527413] [Abstract] Cited for: IDENTIFICATION IN A MRNP COMPLEX WITH RENT1; RENT2 AND RENT3B.
[7]	"The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci." Ingelfinger D., Arndt-Jovin D.J., Luehrmann R., Achsel T. RNA 8:1489-1501(2002) [PubMed: 12515382] [Abstract] Cited for: SUBCELLULAR LOCATION.
[8]	"The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma." Zhang K., Dion N., Fuchs B., Damron T., Gitelis S., Irwin R., O'Connor M., Schwartz H., Scully S.P., Rock M.G., Bolander M.E., Sarkar G. Gene 298:121-127(2002) [PubMed: 12426100] [Abstract] Cited for: POTENTIAL TUMOR SUPPRESSION ROLE IN OSTEOGENIC SARCOMA, TISSUE SPECIFICITY.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1173 AND SER-1176, MASS SPECTROMETRY. Tissue: Epithelium.
[10]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY137776 mRNA. Translation: AAN11306.1. AL133623 mRNA. Translation: CAB63749.1. BX640905 mRNA. Translation: CAE45950.1. CR627396 mRNA. Translation: CAH10490.1. CR749518 mRNA. Translation: CAH18332.1. BC039314 mRNA. Translation: AAH39314.1. BC048104 mRNA. Translation: AAH48104.1. AK096177 mRNA. Translation: BAC04718.1.
IPI	IPI00328115. IPI00657645. IPI00657805.
PIR	T43461.
RefSeq	NP_001036069.1. NP_061874.3.
UniGene	Hs.435103
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZH2. 20 interactions.
Proteomic databases
PRIDE	Q8IZH2.
Genome annotation databases
Ensembl	ENSG00000114127. Homo sapiens. [Contig view]
GeneID	54464.
KEGG	hsa:54464.
NMPDR	fig|9606.3.peg.23297.
UCSC	uc003eus.1. human. uc003eut.1. human. uc003euw.2. human.
Organism-specific databases
GeneCards	GC03M143508.
HGNC	HGNC:30654. XRN1.
MIM	607994. gene.
PharmGKB	PA134878471.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8IZH2.
OMA	Q8IZH2. RVCAPEE.
Gene expression databases
ArrayExpress	Q8IZH2.
Bgee	Q8IZH2.
CleanEx	HS_XRN1.
GermOnline	ENSG00000114127. Homo sapiens.
Family and domain databases
InterPro	IPR016494. 5_3_exoribonuclease_1. IPR004859. Put_53exo. [Graphical view]
Pfam	PF03159. XRN_N. 1 hit. [Graphical view]
PIRSF	PIRSF006743. Exonuclease_Xnr1. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	56731.
SOURCE	Search...

Entry information

Entry name

XRN1_HUMAN

Accession

Primary (citable) accession number: Q8IZH2
Secondary accession number(s): Q4G0S3 , Q68D88, Q6AI24, Q6MZS8, Q86WS7, Q8N8U4, Q9UF39

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	March 1, 2003
Last modified:	July 7, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)