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Q8IZH2

- XRN1_HUMAN

UniProt

Q8IZH2 - XRN1_HUMAN

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Protein
5'-3' exoribonuclease 1
Gene
XRN1, SEP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA By similarity. Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).2 Publications

GO - Molecular functioni

  1. 5'-3' exonuclease activity Source: InterPro
  2. DNA binding Source: UniProtKB-KW
  3. poly(A) RNA binding Source: UniProtKB
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. RNA metabolic process Source: Reactome
  2. exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Source: Reactome
  3. gene expression Source: Reactome
  4. histone mRNA catabolic process Source: UniProtKB
  5. mRNA metabolic process Source: Reactome
  6. nuclear mRNA surveillance Source: UniProtKB
  7. nuclear-transcribed mRNA catabolic process Source: UniProtKB
  8. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Reactome
  9. rRNA catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

ReactomeiREACT_20518. mRNA decay by 5' to 3' exoribonuclease.
REACT_24915. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.
REACT_25064. Tristetraprolin (TTP) destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
5'-3' exoribonuclease 1 (EC:3.1.13.-)
Alternative name(s):
Strand-exchange protein 1 homolog
Gene namesi
Name:XRN1
Synonyms:SEP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30654. XRN1.

Subcellular locationi

Cytoplasm
Note: Discrete foci at the inner surface of the cell membrane.3 Publications

GO - Cellular componenti

  1. cytoplasmic mRNA processing body Source: Ensembl
  2. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134878471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170617065'-3' exoribonuclease 1
PRO_0000071392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1348 – 13481Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IZH2.
PaxDbiQ8IZH2.
PRIDEiQ8IZH2.

PTM databases

PhosphoSiteiQ8IZH2.

Expressioni

Tissue specificityi

Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.1 Publication

Inductioni

By GDNF/glial cell line-derived neurotrophic factor.1 Publication

Gene expression databases

ArrayExpressiQ8IZH2.
BgeeiQ8IZH2.
CleanExiHS_XRN1.
GenevestigatoriQ8IZH2.

Organism-specific databases

HPAiHPA035005.
HPA035006.

Interactioni

Subunit structurei

Associates with alpha and beta tubulins By similarity. Found in a mRNP complex with UPF1, UPF2, UPF3B and XRN1. Interacts with ZC3HAV1 in an RNA-dependent manner. Interacts with DIS3L2.3 Publications

Protein-protein interaction databases

BioGridi119970. 72 interactions.
DIPiDIP-31174N.
IntActiQ8IZH2. 25 interactions.
STRINGi9606.ENSP00000264951.

Structurei

3D structure databases

ProteinModelPortaliQ8IZH2.
SMRiQ8IZH2. Positions 1-600.

Family & Domainsi

Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.

Phylogenomic databases

eggNOGiCOG5049.
HOVERGENiHBG094164.
InParanoidiQ8IZH2.
KOiK12618.
OMAiCKQRKSN.
OrthoDBiEOG7S7SCW.
PhylomeDBiQ8IZH2.
TreeFamiTF105757.

Family and domain databases

InterProiIPR027073. 5_3_exoribonuclease.
IPR016494. 5_3_exoribonuclease_1.
IPR004859. Put_53exo.
[Graphical view]
PANTHERiPTHR12341. PTHR12341. 1 hit.
PfamiPF03159. XRN_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006743. Exonuclease_Xnr1. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZH2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD     50
VHFRISDDKI FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR 100
RFRSAKEAED KIKKAIEKGE TLPTEARFDS NCITPGTEFM ARLHEHLKYF 150
VNMKISTDKS WQGVTIYFSG HETPGEGEHK IMEFIRSEKA KPDHDPNTRH 200
CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA PEETTFHLLH 250
LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL 300
HINHDALPLL YGTYVTILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH 350
FSEVFVDLKW FESKVGNKYL NEAAGVAAEE ARNYKEKKKL KGQENSLCWT 400
ALDKNEGEMI TSKDNLEDET EDDDLFETEF RQYKRTYYMT KMGVDVVSDD 450
FLADQAACYV QAIQWILHYY YHGVQSWSWY YPYHYAPFLS DIHNISTLKI 500
HFELGKPFKP FEQLLAVLPA ASKNLLPACY QHLMTNEDSP IIEYYPPDFK 550
TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKKEER KRNQHSECLM 600
CWYDRDTEFI YPSPWPEKFP AIERCCTRYK IISLDAWRVD INKNKITRID 650
QKALYFCGFP TLKHIRHKFF LKKSGVQVFQ QSSRGENMML EILVDAESDE 700
LTVENVASSV LGKSVFVNWP HLEEARVVAV SDGETKFYLE EPPGTQKLYS 750
GRTAPPSKVV HLGDKEQSNW AKEVQGISEH YLRRKGIIIN ETSAVVYAQL 800
LTGRKYQINQ NGEVRLEKQW SKQVVPFVYQ TIVKDIRAFD SRFSNIKTLD 850
DLFPLRSMVF MLGTPYYGCT GEVQDSGDVI TEGRIRVIFS IPCEPNLDAL 900
IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK 950
ANVGLNLKFN KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY 1000
IAKNSQEDVF YEDDIWPGEN ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ 1050
ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV KPHLLYRPLE QQHGVIPDRD 1100
AEFCLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF EVLFDEEFPG 1150
GLTIRCSPGR GYRLPTSALV NLSHGSRSET GNQKLTAIVK PQPAVHQHSS 1200
SSSVSSGHLG ALNHSPQSLF VPTQVPTKDD DEFCNIWQSL QGSGKMQYFQ 1250
PTIQEKGAVL PQEISQVNQH HKSGFNDNSV KYQQRKHDPH RKFKEECKSP 1300
KAECWSQKMS NKQPNSGIEN FLASLNISKE NEVQSSHHGE PPSEEHLSPQ 1350
SFAMGTRMLK EILKIDGSNT VDHKNEIKQI ANEIPVSSNR RDEYGLPSQP 1400
KQNKKLASYM NKPHSANEYH NVQSMDNMCW PAPSQIPPVS TPVTELSRIC 1450
SLVGMPQPDF SFLRMPQTMT VCQVKLSNGL LVHGPQCHSE NEAKEKAALF 1500
ALQQLGSLGM NFPLPSQVFA NYPSAVPPGT IPPAFPPPTG WDHYGSNYAL 1550
GAANIMPSSS HLFGSMPWGP SVPVPGKPFH HTLYSGTMPM AGGIPGGVHN 1600
QFIPLQVTKK RVANKKNFEN KEAQSSQATP VQTSQPDSSN IVKVSPRESS 1650
SASLKSSPIA QPASSFQVET ASQGHSISHH KSTPISSSRR KSRKLAVNFG 1700
VSKPSE 1706
Length:1,706
Mass (Da):194,107
Last modified:March 1, 2003 - v1
Checksum:iD06A76208DE78698
GO
Isoform 2 (identifier: Q8IZH2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1354: M → MK
     1540-1552: Missing.

Show »
Length:1,694
Mass (Da):192,843
Checksum:i25AD7CD0191A4E05
GO
Isoform 3 (identifier: Q8IZH2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-459: DDFLADQAACY → EYVFANAFILK
     460-1706: Missing.

Show »
Length:459
Mass (Da):53,818
Checksum:i2C546FA5EDB81BC3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti674 – 6741S → G.
Corresponds to variant rs35214510 [ dbSNP | Ensembl ].
VAR_053000
Natural varianti1259 – 12591V → A.
Corresponds to variant rs35902661 [ dbSNP | Ensembl ].
VAR_053001

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei449 – 45911DDFLADQAACY → EYVFANAFILK in isoform 3.
VSP_016692Add
BLAST
Alternative sequencei460 – 17061247Missing in isoform 3.
VSP_016693Add
BLAST
Alternative sequencei1354 – 13541M → MK in isoform 2.
VSP_016694
Alternative sequencei1540 – 155213Missing in isoform 2.
VSP_016695Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481D → G in CAE45950. 1 Publication
Sequence conflicti55 – 551I → T in BAC04718. 1 Publication
Sequence conflicti113 – 1131K → E in CAH18332. 1 Publication
Sequence conflicti142 – 1421R → K in AAH48104. 1 Publication
Sequence conflicti148 – 1481K → E in CAH18332. 1 Publication
Sequence conflicti572 – 5721Missing in CAB63749. 1 Publication
Sequence conflicti722 – 7221L → I in CAE45950. 1 Publication
Sequence conflicti834 – 8341K → R in CAH18332. 1 Publication
Sequence conflicti1250 – 12501Q → R in CAH18332. 1 Publication
Sequence conflicti1463 – 14631L → F in CAE45950. 1 Publication
Sequence conflicti1686 – 16861S → P in CAH18332. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY137776 mRNA. Translation: AAN11306.1.
AL133623 mRNA. Translation: CAB63749.1.
BX640905 mRNA. Translation: CAE45950.1.
CR627396 mRNA. Translation: CAH10490.1.
CR749518 mRNA. Translation: CAH18332.1.
BC039314 mRNA. Translation: AAH39314.1.
BC048104 mRNA. Translation: AAH48104.1.
AK096177 mRNA. Translation: BAC04718.1.
CCDSiCCDS3123.1. [Q8IZH2-1]
CCDS63801.1. [Q8IZH2-2]
PIRiT43461.
RefSeqiNP_001269786.1. NM_001282857.1. [Q8IZH2-2]
NP_001269788.1. NM_001282859.1. [Q8IZH2-3]
NP_061874.3. NM_019001.4. [Q8IZH2-1]
UniGeneiHs.435103.

Genome annotation databases

EnsembliENST00000264951; ENSP00000264951; ENSG00000114127. [Q8IZH2-1]
ENST00000392981; ENSP00000376707; ENSG00000114127. [Q8IZH2-2]
ENST00000463916; ENSP00000418404; ENSG00000114127. [Q8IZH2-3]
GeneIDi54464.
KEGGihsa:54464.
UCSCiuc003eus.3. human. [Q8IZH2-1]
uc003euu.3. human. [Q8IZH2-2]
uc003euw.3. human. [Q8IZH2-3]

Polymorphism databases

DMDMi74714582.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY137776 mRNA. Translation: AAN11306.1 .
AL133623 mRNA. Translation: CAB63749.1 .
BX640905 mRNA. Translation: CAE45950.1 .
CR627396 mRNA. Translation: CAH10490.1 .
CR749518 mRNA. Translation: CAH18332.1 .
BC039314 mRNA. Translation: AAH39314.1 .
BC048104 mRNA. Translation: AAH48104.1 .
AK096177 mRNA. Translation: BAC04718.1 .
CCDSi CCDS3123.1. [Q8IZH2-1 ]
CCDS63801.1. [Q8IZH2-2 ]
PIRi T43461.
RefSeqi NP_001269786.1. NM_001282857.1. [Q8IZH2-2 ]
NP_001269788.1. NM_001282859.1. [Q8IZH2-3 ]
NP_061874.3. NM_019001.4. [Q8IZH2-1 ]
UniGenei Hs.435103.

3D structure databases

ProteinModelPortali Q8IZH2.
SMRi Q8IZH2. Positions 1-600.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119970. 72 interactions.
DIPi DIP-31174N.
IntActi Q8IZH2. 25 interactions.
STRINGi 9606.ENSP00000264951.

PTM databases

PhosphoSitei Q8IZH2.

Polymorphism databases

DMDMi 74714582.

Proteomic databases

MaxQBi Q8IZH2.
PaxDbi Q8IZH2.
PRIDEi Q8IZH2.

Protocols and materials databases

DNASUi 54464.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264951 ; ENSP00000264951 ; ENSG00000114127 . [Q8IZH2-1 ]
ENST00000392981 ; ENSP00000376707 ; ENSG00000114127 . [Q8IZH2-2 ]
ENST00000463916 ; ENSP00000418404 ; ENSG00000114127 . [Q8IZH2-3 ]
GeneIDi 54464.
KEGGi hsa:54464.
UCSCi uc003eus.3. human. [Q8IZH2-1 ]
uc003euu.3. human. [Q8IZH2-2 ]
uc003euw.3. human. [Q8IZH2-3 ]

Organism-specific databases

CTDi 54464.
GeneCardsi GC03M142025.
HGNCi HGNC:30654. XRN1.
HPAi HPA035005.
HPA035006.
MIMi 607994. gene.
neXtProti NX_Q8IZH2.
PharmGKBi PA134878471.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5049.
HOVERGENi HBG094164.
InParanoidi Q8IZH2.
KOi K12618.
OMAi CKQRKSN.
OrthoDBi EOG7S7SCW.
PhylomeDBi Q8IZH2.
TreeFami TF105757.

Enzyme and pathway databases

Reactomei REACT_20518. mRNA decay by 5' to 3' exoribonuclease.
REACT_24915. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.
REACT_25064. Tristetraprolin (TTP) destabilizes mRNA.

Miscellaneous databases

ChiTaRSi XRN1. human.
GenomeRNAii 54464.
NextBioi 56731.
PROi Q8IZH2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IZH2.
Bgeei Q8IZH2.
CleanExi HS_XRN1.
Genevestigatori Q8IZH2.

Family and domain databases

InterProi IPR027073. 5_3_exoribonuclease.
IPR016494. 5_3_exoribonuclease_1.
IPR004859. Put_53exo.
[Graphical view ]
PANTHERi PTHR12341. PTHR12341. 1 hit.
Pfami PF03159. XRN_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF006743. Exonuclease_Xnr1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system."
    Shimoyama Y., Morikawa Y., Ichihara M., Kodama Y., Fukuda N., Hayashi H., Morinaga T., Iwashita T., Murakumo Y., Takahashi M.
    Neuroscience 121:899-906(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION BY GDNF, SUBCELLULAR LOCATION.
    Tissue: Neuroblastoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Fetal kidney, Small intestine and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain and Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-473 (ISOFORMS 1/2).
    Tissue: Mesangial cell.
  5. "Cloning and characterization of human Sep1 (hSEP1) gene and cytoplasmic localization of its product."
    Sato Y., Shimamoto A., Shobuike T., Sugimoto M., Ikeda H., Kuroda S., Furuichi Y.
    DNA Res. 5:241-246(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 2), SUBCELLULAR LOCATION.
  6. "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities."
    Lejeune F., Li X., Maquat L.E.
    Mol. Cell 12:675-687(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A MRNP COMPLEX WITH UPF1; UPF2 AND UPF3B.
  7. "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci."
    Ingelfinger D., Arndt-Jovin D.J., Luehrmann R., Achsel T.
    RNA 8:1489-1501(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma."
    Zhang K., Dion N., Fuchs B., Damron T., Gitelis S., Irwin R., O'Connor M., Schwartz H., Scully S.P., Rock M.G., Bolander M.E., Sarkar G.
    Gene 298:121-127(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: POTENTIAL TUMOR SUPPRESSION ROLE IN OSTEOGENIC SARCOMA, TISSUE SPECIFICITY.
  9. "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'."
    Mullen T.E., Marzluff W.F.
    Genes Dev. 22:50-65(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HISTONE MRNA DEGRADATION ACTIVITY.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation."
    Zhu Y., Chen G., Lv F., Wang X., Ji X., Xu Y., Sun J., Wu L., Zheng Y.T., Gao G.
    Proc. Natl. Acad. Sci. U.S.A. 108:15834-15839(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZC3HAV1.
  13. "Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA."
    Lubas M., Damgaard C.K., Tomecki R., Cysewski D., Jensen T.H., Dziembowski A.
    EMBO J. 32:1855-1868(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DIS3L2.

Entry informationi

Entry nameiXRN1_HUMAN
AccessioniPrimary (citable) accession number: Q8IZH2
Secondary accession number(s): Q4G0S3
, Q68D88, Q6AI24, Q6MZS8, Q86WS7, Q8N8U4, Q9UF39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Down-regulated in OGS biopsy.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi