Q8IZH2 (XRN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-3' exoribonuclease 1
EC=3.1.11.-

Alternative name(s):
Strand-exchange protein 1 homolog

Gene names

Name:	XRN1
Synonyms:	SEP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1706 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA By similarity. Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). Ref.8 Ref.9
Subunit structure	Associates with alpha and beta tubulins By similarity. Found in a mRNP complex with UPF1, UPF2, UPF3B and XRN1. Interacts with ZC3HAV1 in an RNA-dependent manner. Ref.6 Ref.12
Subcellular location	Cytoplasm. Note: Discrete foci at the inner surface of the cell membrane. Ref.1 Ref.5 Ref.7
Tissue specificity	Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. Ref.8
Induction	By GDNF/glial cell line-derived neurotrophic factor. Ref.1
Miscellaneous	Down-regulated in OGS biopsy.
Sequence similarities	Belongs to the 5'-3' exonuclease family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Tumor suppressor
Ligand	DNA-binding RNA-binding
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Traceable author statement. Source: Reactome gene expression Traceable author statement. Source: Reactome histone mRNA catabolic process Inferred from mutant phenotype Ref.9. Source: UniProtKB nuclear mRNA surveillance Inferred from mutant phenotype PubMed 17545563. Source: UniProtKB nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC rRNA catabolic process Inferred from mutant phenotype PubMed 20368444. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA cytoplasmic mRNA processing body Inferred from electronic annotation. Source: Compara cytosol Traceable author statement. Source: Reactome intermediate filament cytoskeleton Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	5'-3' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZH2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZH2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1354: M → MK
     1540-1552: Missing.

Isoform 3 (identifier: Q8IZH2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     449-459: DDFLADQAACY → EYVFANAFILK
     460-1706: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1706	1706	5'-3' exoribonuclease 1		PRO_0000071392
Natural variations
	Alternative sequence	449 – 459	11	DDFLADQAACY → EYVFANAFILK in isoform 3.		VSP_016692
	Alternative sequence	460 – 1706	1247	Missing in isoform 3.		VSP_016693
	Alternative sequence	1354	1	M → MK in isoform 2.		VSP_016694
	Alternative sequence	1540 – 1552	13	Missing in isoform 2.		VSP_016695
	Natural variant	674	1	S → G. Corresponds to variant rs35214510 [ dbSNP | Ensembl ].		VAR_053000
	Natural variant	1259	1	V → A. Corresponds to variant rs35902661 [ dbSNP | Ensembl ].		VAR_053001
Experimental info
	Sequence conflict	48	1	D → G in CAE45950. Ref.2
	Sequence conflict	55	1	I → T in BAC04718. Ref.4
	Sequence conflict	113	1	K → E in CAH18332. Ref.2
	Sequence conflict	142	1	R → K in AAH48104. Ref.3
	Sequence conflict	148	1	K → E in CAH18332. Ref.2
	Sequence conflict	572	1	Missing in CAB63749. Ref.2
	Sequence conflict	722	1	L → I in CAE45950. Ref.2
	Sequence conflict	834	1	K → R in CAH18332. Ref.2
	Sequence conflict	1250	1	Q → R in CAH18332. Ref.2
	Sequence conflict	1463	1	L → F in CAE45950. Ref.2
	Sequence conflict	1686	1	S → P in CAH18332. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D06A76208DE78698	FASTA	1,706	194,107
	10 20 30 40 50 60 MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI 70 80 90 100 110 120 FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE 130 140 150 160 170 180 TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK 190 200 210 220 230 240 IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA 250 260 270 280 290 300 PEETTFHLLH LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL 310 320 330 340 350 360 HINHDALPLL YGTYVTILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW 370 380 390 400 410 420 FESKVGNKYL NEAAGVAAEE ARNYKEKKKL KGQENSLCWT ALDKNEGEMI TSKDNLEDET 430 440 450 460 470 480 EDDDLFETEF RQYKRTYYMT KMGVDVVSDD FLADQAACYV QAIQWILHYY YHGVQSWSWY 490 500 510 520 530 540 YPYHYAPFLS DIHNISTLKI HFELGKPFKP FEQLLAVLPA ASKNLLPACY QHLMTNEDSP 550 560 570 580 590 600 IIEYYPPDFK TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKKEER KRNQHSECLM 610 620 630 640 650 660 CWYDRDTEFI YPSPWPEKFP AIERCCTRYK IISLDAWRVD INKNKITRID QKALYFCGFP 670 680 690 700 710 720 TLKHIRHKFF LKKSGVQVFQ QSSRGENMML EILVDAESDE LTVENVASSV LGKSVFVNWP 730 740 750 760 770 780 HLEEARVVAV SDGETKFYLE EPPGTQKLYS GRTAPPSKVV HLGDKEQSNW AKEVQGISEH 790 800 810 820 830 840 YLRRKGIIIN ETSAVVYAQL LTGRKYQINQ NGEVRLEKQW SKQVVPFVYQ TIVKDIRAFD 850 860 870 880 890 900 SRFSNIKTLD DLFPLRSMVF MLGTPYYGCT GEVQDSGDVI TEGRIRVIFS IPCEPNLDAL 910 920 930 940 950 960 IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN 970 980 990 1000 1010 1020 KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY IAKNSQEDVF YEDDIWPGEN 1030 1040 1050 1060 1070 1080 ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV 1090 1100 1110 1120 1130 1140 KPHLLYRPLE QQHGVIPDRD AEFCLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF 1150 1160 1170 1180 1190 1200 EVLFDEEFPG GLTIRCSPGR GYRLPTSALV NLSHGSRSET GNQKLTAIVK PQPAVHQHSS 1210 1220 1230 1240 1250 1260 SSSVSSGHLG ALNHSPQSLF VPTQVPTKDD DEFCNIWQSL QGSGKMQYFQ PTIQEKGAVL 1270 1280 1290 1300 1310 1320 PQEISQVNQH HKSGFNDNSV KYQQRKHDPH RKFKEECKSP KAECWSQKMS NKQPNSGIEN 1330 1340 1350 1360 1370 1380 FLASLNISKE NEVQSSHHGE PPSEEHLSPQ SFAMGTRMLK EILKIDGSNT VDHKNEIKQI 1390 1400 1410 1420 1430 1440 ANEIPVSSNR RDEYGLPSQP KQNKKLASYM NKPHSANEYH NVQSMDNMCW PAPSQIPPVS 1450 1460 1470 1480 1490 1500 TPVTELSRIC SLVGMPQPDF SFLRMPQTMT VCQVKLSNGL LVHGPQCHSE NEAKEKAALF 1510 1520 1530 1540 1550 1560 ALQQLGSLGM NFPLPSQVFA NYPSAVPPGT IPPAFPPPTG WDHYGSNYAL GAANIMPSSS 1570 1580 1590 1600 1610 1620 HLFGSMPWGP SVPVPGKPFH HTLYSGTMPM AGGIPGGVHN QFIPLQVTKK RVANKKNFEN 1630 1640 1650 1660 1670 1680 KEAQSSQATP VQTSQPDSSN IVKVSPRESS SASLKSSPIA QPASSFQVET ASQGHSISHH 1690 1700 KSTPISSSRR KSRKLAVNFG VSKPSE
	Isoform 2 [UniParc]. Checksum: 25AD7CD0191A4E05	FASTA	1,694	192,843
	10 20 30 40 50 60 MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI 70 80 90 100 110 120 FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE 130 140 150 160 170 180 TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK 190 200 210 220 230 240 IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA 250 260 270 280 290 300 PEETTFHLLH LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL 310 320 330 340 350 360 HINHDALPLL YGTYVTILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW 370 380 390 400 410 420 FESKVGNKYL NEAAGVAAEE ARNYKEKKKL KGQENSLCWT ALDKNEGEMI TSKDNLEDET 430 440 450 460 470 480 EDDDLFETEF RQYKRTYYMT KMGVDVVSDD FLADQAACYV QAIQWILHYY YHGVQSWSWY 490 500 510 520 530 540 YPYHYAPFLS DIHNISTLKI HFELGKPFKP FEQLLAVLPA ASKNLLPACY QHLMTNEDSP 550 560 570 580 590 600 IIEYYPPDFK TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKKEER KRNQHSECLM 610 620 630 640 650 660 CWYDRDTEFI YPSPWPEKFP AIERCCTRYK IISLDAWRVD INKNKITRID QKALYFCGFP 670 680 690 700 710 720 TLKHIRHKFF LKKSGVQVFQ QSSRGENMML EILVDAESDE LTVENVASSV LGKSVFVNWP 730 740 750 760 770 780 HLEEARVVAV SDGETKFYLE EPPGTQKLYS GRTAPPSKVV HLGDKEQSNW AKEVQGISEH 790 800 810 820 830 840 YLRRKGIIIN ETSAVVYAQL LTGRKYQINQ NGEVRLEKQW SKQVVPFVYQ TIVKDIRAFD 850 860 870 880 890 900 SRFSNIKTLD DLFPLRSMVF MLGTPYYGCT GEVQDSGDVI TEGRIRVIFS IPCEPNLDAL 910 920 930 940 950 960 IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN 970 980 990 1000 1010 1020 KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY IAKNSQEDVF YEDDIWPGEN 1030 1040 1050 1060 1070 1080 ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV 1090 1100 1110 1120 1130 1140 KPHLLYRPLE QQHGVIPDRD AEFCLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF 1150 1160 1170 1180 1190 1200 EVLFDEEFPG GLTIRCSPGR GYRLPTSALV NLSHGSRSET GNQKLTAIVK PQPAVHQHSS 1210 1220 1230 1240 1250 1260 SSSVSSGHLG ALNHSPQSLF VPTQVPTKDD DEFCNIWQSL QGSGKMQYFQ PTIQEKGAVL 1270 1280 1290 1300 1310 1320 PQEISQVNQH HKSGFNDNSV KYQQRKHDPH RKFKEECKSP KAECWSQKMS NKQPNSGIEN 1330 1340 1350 1360 1370 1380 FLASLNISKE NEVQSSHHGE PPSEEHLSPQ SFAMKGTRML KEILKIDGSN TVDHKNEIKQ 1390 1400 1410 1420 1430 1440 IANEIPVSSN RRDEYGLPSQ PKQNKKLASY MNKPHSANEY HNVQSMDNMC WPAPSQIPPV 1450 1460 1470 1480 1490 1500 STPVTELSRI CSLVGMPQPD FSFLRMPQTM TVCQVKLSNG LLVHGPQCHS ENEAKEKAAL 1510 1520 1530 1540 1550 1560 FALQQLGSLG MNFPLPSQVF ANYPSAVPPG TIPPAFPPPT ANIMPSSSHL FGSMPWGPSV 1570 1580 1590 1600 1610 1620 PVPGKPFHHT LYSGTMPMAG GIPGGVHNQF IPLQVTKKRV ANKKNFENKE AQSSQATPVQ 1630 1640 1650 1660 1670 1680 TSQPDSSNIV KVSPRESSSA SLKSSPIAQP ASSFQVETAS QGHSISHHKS TPISSSRRKS 1690 RKLAVNFGVS KPSE
	Isoform 3 [UniParc]. Checksum: 2C546FA5EDB81BC3	FASTA	459	53,818
	10 20 30 40 50 60 MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI 70 80 90 100 110 120 FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE 130 140 150 160 170 180 TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK 190 200 210 220 230 240 IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA 250 260 270 280 290 300 PEETTFHLLH LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL 310 320 330 340 350 360 HINHDALPLL YGTYVTILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW 370 380 390 400 410 420 FESKVGNKYL NEAAGVAAEE ARNYKEKKKL KGQENSLCWT ALDKNEGEMI TSKDNLEDET 430 440 450 EDDDLFETEF RQYKRTYYMT KMGVDVVSEY VFANAFILK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system." Shimoyama Y., Morikawa Y., Ichihara M., Kodama Y., Fukuda N., Hayashi H., Morinaga T., Iwashita T., Murakumo Y., Takahashi M. Neuroscience 121:899-906(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION BY GDNF, SUBCELLULAR LOCATION. Tissue: Neuroblastoma.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Fetal kidney, Small intestine and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain and Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-473 (ISOFORMS 1/2). Tissue: Mesangial cell.
[5]	"Cloning and characterization of human Sep1 (hSEP1) gene and cytoplasmic localization of its product." Sato Y., Shimamoto A., Shobuike T., Sugimoto M., Ikeda H., Kuroda S., Furuichi Y. DNA Res. 5:241-246(1998) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 2), SUBCELLULAR LOCATION.
[6]	"Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities." Lejeune F., Li X., Maquat L.E. Mol. Cell 12:675-687(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A MRNP COMPLEX WITH UPF1; UPF2 AND UPF3B.
[7]	"The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci." Ingelfinger D., Arndt-Jovin D.J., Luehrmann R., Achsel T. RNA 8:1489-1501(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[8]	"The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma." Zhang K., Dion N., Fuchs B., Damron T., Gitelis S., Irwin R., O'Connor M., Schwartz H., Scully S.P., Rock M.G., Bolander M.E., Sarkar G. Gene 298:121-127(2002) [PubMed] [Europe PMC] [Abstract] Cited for: POTENTIAL TUMOR SUPPRESSION ROLE IN OSTEOGENIC SARCOMA, TISSUE SPECIFICITY.
[9]	"Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'." Mullen T.E., Marzluff W.F. Genes Dev. 22:50-65(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN HISTONE MRNA DEGRADATION ACTIVITY.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation." Zhu Y., Chen G., Lv F., Wang X., Ji X., Xu Y., Sun J., Wu L., Zheng Y.T., Gao G. Proc. Natl. Acad. Sci. U.S.A. 108:15834-15839(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ZC3HAV1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY137776 mRNA. Translation: AAN11306.1. AL133623 mRNA. Translation: CAB63749.1. BX640905 mRNA. Translation: CAE45950.1. CR627396 mRNA. Translation: CAH10490.1. CR749518 mRNA. Translation: CAH18332.1. BC039314 mRNA. Translation: AAH39314.1. BC048104 mRNA. Translation: AAH48104.1. AK096177 mRNA. Translation: BAC04718.1.
IPI	IPI00328115. IPI00657645. IPI00657805.
PIR	T43461.
RefSeq	NP_001036069.1. NM_001042604.1. NP_061874.3. NM_019001.3.
UniGene	Hs.435103.
3D structure databases
ProteinModelPortal	Q8IZH2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IZH2. 25 interactions.
STRING	9606.ENSP00000264951.
PTM databases
PhosphoSite	Q8IZH2.
Polymorphism databases
DMDM	74714582.
Proteomic databases
PaxDb	Q8IZH2.
PRIDE	Q8IZH2.
Protocols and materials databases
DNASU	54464.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264951; ENSP00000264951; ENSG00000114127. ENST00000392981; ENSP00000376707; ENSG00000114127. ENST00000463916; ENSP00000418404; ENSG00000114127.
GeneID	54464.
KEGG	hsa:54464.
UCSC	uc003eus.3. human. uc003euu.3. human. uc003euw.3. human.
Organism-specific databases
CTD	54464.
GeneCards	GC03M142025.
HGNC	HGNC:30654. XRN1.
HPA	HPA035005. HPA035006.
MIM	607994. gene.
neXtProt	NX_Q8IZH2.
PharmGKB	PA134878471.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5049.
HOVERGEN	HBG094164.
InParanoid	Q8IZH2.
KO	K12618.
OMA	CKQRKSN.
OrthoDB	EOG49S65H.
PhylomeDB	Q8IZH2.
Enzyme and pathway databases
Reactome	REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q8IZH2.
Bgee	Q8IZH2.
CleanEx	HS_XRN1.
Genevestigator	Q8IZH2.
GermOnline	ENSG00000114127. Homo sapiens.
Family and domain databases
InterPro	IPR027073. 5_3_exoribonuclease. IPR016494. 5_3_exoribonuclease_1. IPR004859. Put_53exo. [Graphical view]
PANTHER	PTHR12341. PTHR12341. 1 hit.
Pfam	PF03159. XRN_N. 1 hit. [Graphical view]
PIRSF	PIRSF006743. Exonuclease_Xnr1. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	XRN1. human.
GenomeRNAi	54464.
NextBio	56731.
SOURCE	Search...

Entry information

Entry name

XRN1_HUMAN

Accession

Primary (citable) accession number: Q8IZH2
Secondary accession number(s): Q4G0S3 , Q68D88, Q6AI24, Q6MZS8, Q86WS7, Q8N8U4, Q9UF39

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.