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Q8IZF7

- GP111_HUMAN

UniProt

Q8IZF7 - GP111_HUMAN

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Protein

Probable G-protein coupled receptor 111

Gene

GPR111

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 111
Alternative name(s):
G-protein coupled receptor PGR20
Gene namesi
Name:GPR111
Synonyms:PGR20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:18991. GPR111.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 451451ExtracellularSequence AnalysisAdd
BLAST
Transmembranei452 – 47221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini473 – 48715CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei488 – 50821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini509 – 53022ExtracellularSequence AnalysisAdd
BLAST
Transmembranei531 – 55121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini552 – 5576CytoplasmicSequence Analysis
Transmembranei558 – 57821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini579 – 60628ExtracellularSequence AnalysisAdd
BLAST
Transmembranei607 – 62721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini628 – 65023CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei651 – 67121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini672 – 6743ExtracellularSequence Analysis
Transmembranei675 – 69521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini696 – 70813CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984088.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Probable G-protein coupled receptor 111PRO_0000070334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi358 – 3581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZF7.
PRIDEiQ8IZF7.

PTM databases

PhosphoSiteiQ8IZF7.

Expressioni

Gene expression databases

BgeeiQ8IZF7.
CleanExiHS_GPR111.
ExpressionAtlasiQ8IZF7. baseline.
GenevestigatoriQ8IZF7.

Organism-specific databases

HPAiHPA035507.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381727.

Structurei

3D structure databases

ProteinModelPortaliQ8IZF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini391 – 44151GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313007.
GeneTreeiENSGT00770000120478.
HOGENOMiHOG000112762.
HOVERGENiHBG051768.
InParanoidiQ8IZF7.
KOiK08454.
OMAiILIVFHT.
PhylomeDBiQ8IZF7.
TreeFamiTF316380.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZF7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLTAYGNRR VQPGELPFGA NLTLIHTRAQ PVICSKLLLT KRVSPISFFL
60 70 80 90 100
SKFQNSWGED GWVQLDQLPS PNAVSSDQVH CSAGCTHRKC GWAASKSKEK
110 120 130 140 150
VPARPHGVCD GVCTDYSQCT QPCPPDTQGN MGFSCRQKTW HKITDTCQTL
160 170 180 190 200
NALNIFEEDS RLVQPFEDNI KISVYTGKSE TITDMLLQKC PTDLSCVIRN
210 220 230 240 250
IQQSPWIPGN IAVIVQLLHN ISTAIWTGVD EAKMQSYSTI ANHILNSKSI
260 270 280 290 300
SNWTFIPDRN SSYILLHSVN SFARRLFIDK HPVDISDVFI HTMGTTISGD
310 320 330 340 350
NIGKNFTFSM RINDTSNEVT GRVLISRDEL RKVPSPSQVI SIAFPTIGAI
360 370 380 390 400
LEASLLENVT VNGLVLSAIL PKELKRISLI FEKISKSEER RTQCVGWHSV
410 420 430 440 450
ENRWDQQACK MIQENSQQAV CKCRPSKLFT SFSILMSPHI LESLILTYIT
460 470 480 490 500
YVGLGISICS LILCLSIEVL VWSQVTKTEI TYLRHVCIVN IAATLLMADV
510 520 530 540 550
WFIVASFLSG PITHHKGCVA ATFFVHFFYL SVFFWMLAKA LLILYGIMIV
560 570 580 590 600
FHTLPKSVLV ASLFSVGYGC PLAIAAITVA ATEPGKGYLR PEICWLNWDM
610 620 630 640 650
TKALLAFVIP ALAIVVVNLI TVTLVIVKTQ RAAIGNSMFQ EVRAIVRISK
660 670 680 690 700
NIAILTPLLG LTWGFGVATV IDDRSLAFHI IFSLLNAFQV SPDASDQVQS

ERIHEDVL
Length:708
Mass (Da):78,569
Last modified:March 1, 2003 - v1
Checksum:i3DE541DD1D723966
GO
Isoform 2 (identifier: Q8IZF7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     69-92: PSPNAVSSDQVHCSAGCTHRKCGW → MTHILLLYYLVFLLPTESCRTLYQ
     690-708: VSPDASDQVQSERIHEDVL → GFFILVFGTILDPKIREALKG

Show »
Length:642
Mass (Da):71,555
Checksum:i49D59F70D13B0500
GO

Sequence cautioni

The sequence BAC05907.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti427 – 4271K → E in ABC41928. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti148 – 1481Q → R.
Corresponds to variant rs6907125 [ dbSNP | Ensembl ].
VAR_024473
Natural varianti467 – 4671I → V.1 Publication
Corresponds to variant rs9381594 [ dbSNP | Ensembl ].
VAR_024474

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6868Missing in isoform 2. 1 PublicationVSP_040379Add
BLAST
Alternative sequencei69 – 9224PSPNA…RKCGW → MTHILLLYYLVFLLPTESCR TLYQ in isoform 2. 1 PublicationVSP_040380Add
BLAST
Alternative sequencei690 – 70819VSPDA…HEDVL → GFFILVFGTILDPKIREALK G in isoform 2. 1 PublicationVSP_040381Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY140953 mRNA. Translation: AAN46667.1.
AB065684 Genomic DNA. Translation: BAC05907.1. Sequence problems.
DQ315369 mRNA. Translation: ABC41928.1.
AL356421 Genomic DNA. Translation: CAI15578.1.
AB083617 Genomic DNA. Translation: BAB89330.1.
AY255612 mRNA. Translation: AAO85124.1.
RefSeqiNP_722581.4. NM_153839.6. [Q8IZF7-2]
UniGeneiHs.724860.

Genome annotation databases

EnsembliENST00000296862; ENSP00000296862; ENSG00000164393. [Q8IZF7-1]
ENST00000398742; ENSP00000381727; ENSG00000164393. [Q8IZF7-2]
ENST00000467205; ENSP00000425269; ENSG00000164393. [Q8IZF7-2]
GeneIDi222611.
KEGGihsa:222611.
UCSCiuc003oyy.3. human. [Q8IZF7-2]
uc010jzj.1. human. [Q8IZF7-1]

Polymorphism databases

DMDMi59797952.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY140953 mRNA. Translation: AAN46667.1 .
AB065684 Genomic DNA. Translation: BAC05907.1 . Sequence problems.
DQ315369 mRNA. Translation: ABC41928.1 .
AL356421 Genomic DNA. Translation: CAI15578.1 .
AB083617 Genomic DNA. Translation: BAB89330.1 .
AY255612 mRNA. Translation: AAO85124.1 .
RefSeqi NP_722581.4. NM_153839.6. [Q8IZF7-2 ]
UniGenei Hs.724860.

3D structure databases

ProteinModelPortali Q8IZF7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000381727.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8IZF7.

Polymorphism databases

DMDMi 59797952.

Proteomic databases

PaxDbi Q8IZF7.
PRIDEi Q8IZF7.

Protocols and materials databases

DNASUi 222611.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296862 ; ENSP00000296862 ; ENSG00000164393 . [Q8IZF7-1 ]
ENST00000398742 ; ENSP00000381727 ; ENSG00000164393 . [Q8IZF7-2 ]
ENST00000467205 ; ENSP00000425269 ; ENSG00000164393 . [Q8IZF7-2 ]
GeneIDi 222611.
KEGGi hsa:222611.
UCSCi uc003oyy.3. human. [Q8IZF7-2 ]
uc010jzj.1. human. [Q8IZF7-1 ]

Organism-specific databases

CTDi 222611.
GeneCardsi GC06P047624.
HGNCi HGNC:18991. GPR111.
HPAi HPA035507.
neXtProti NX_Q8IZF7.
PharmGKBi PA134984088.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313007.
GeneTreei ENSGT00770000120478.
HOGENOMi HOG000112762.
HOVERGENi HBG051768.
InParanoidi Q8IZF7.
KOi K08454.
OMAi ILIVFHT.
PhylomeDBi Q8IZF7.
TreeFami TF316380.

Miscellaneous databases

GeneWikii GPR111.
GenomeRNAii 222611.
NextBioi 91635.
PROi Q8IZF7.

Gene expression databases

Bgeei Q8IZF7.
CleanExi HS_GPR111.
ExpressionAtlasi Q8IZF7. baseline.
Genevestigatori Q8IZF7.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
    Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
    Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. "Complete coding sequence of GPR111."
    Bonner T.I., Kauffman D., Nagle J.W.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-467.
    Tissue: Testis.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 293-708.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 326-487 (ISOFORM 1).

Entry informationi

Entry nameiGP111_HUMAN
AccessioniPrimary (citable) accession number: Q8IZF7
Secondary accession number(s): Q2PNZ1
, Q86SL6, Q8NGU5, Q8TDT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3