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Q8IZF7 (GP111_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 111
Alternative name(s):
G-protein coupled receptor PGR20
Gene names
Name:GPR111
Synonyms:PGR20
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length708 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Sequence caution

The sequence BAC05907.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IZF7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IZF7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     69-92: PSPNAVSSDQVHCSAGCTHRKCGW → MTHILLLYYLVFLLPTESCRTLYQ
     690-708: VSPDASDQVQSERIHEDVL → GFFILVFGTILDPKIREALKG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 708708Probable G-protein coupled receptor 111
PRO_0000070334

Regions

Topological domain1 – 451451Extracellular Potential
Transmembrane452 – 47221Helical; Name=1; Potential
Topological domain473 – 48715Cytoplasmic Potential
Transmembrane488 – 50821Helical; Name=2; Potential
Topological domain509 – 53022Extracellular Potential
Transmembrane531 – 55121Helical; Name=3; Potential
Topological domain552 – 5576Cytoplasmic Potential
Transmembrane558 – 57821Helical; Name=4; Potential
Topological domain579 – 60628Extracellular Potential
Transmembrane607 – 62721Helical; Name=5; Potential
Topological domain628 – 65023Cytoplasmic Potential
Transmembrane651 – 67121Helical; Name=6; Potential
Topological domain672 – 6743Extracellular Potential
Transmembrane675 – 69521Helical; Name=7; Potential
Topological domain696 – 70813Cytoplasmic Potential
Domain391 – 44151GPS

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2521N-linked (GlcNAc...) Potential
Glycosylation2601N-linked (GlcNAc...) Potential
Glycosylation3051N-linked (GlcNAc...) Potential
Glycosylation3131N-linked (GlcNAc...) Potential
Glycosylation3581N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 6868Missing in isoform 2.
VSP_040379
Alternative sequence69 – 9224PSPNA…RKCGW → MTHILLLYYLVFLLPTESCR TLYQ in isoform 2.
VSP_040380
Alternative sequence690 – 70819VSPDA…HEDVL → GFFILVFGTILDPKIREALK G in isoform 2.
VSP_040381
Natural variant1481Q → R.
Corresponds to variant rs6907125 [ dbSNP | Ensembl ].
VAR_024473
Natural variant4671I → V. Ref.3
Corresponds to variant rs9381594 [ dbSNP | Ensembl ].
VAR_024474

Experimental info

Sequence conflict4271K → E in ABC41928. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 3DE541DD1D723966

FASTA70878,569
        10         20         30         40         50         60 
MGLTAYGNRR VQPGELPFGA NLTLIHTRAQ PVICSKLLLT KRVSPISFFL SKFQNSWGED 

        70         80         90        100        110        120 
GWVQLDQLPS PNAVSSDQVH CSAGCTHRKC GWAASKSKEK VPARPHGVCD GVCTDYSQCT 

       130        140        150        160        170        180 
QPCPPDTQGN MGFSCRQKTW HKITDTCQTL NALNIFEEDS RLVQPFEDNI KISVYTGKSE 

       190        200        210        220        230        240 
TITDMLLQKC PTDLSCVIRN IQQSPWIPGN IAVIVQLLHN ISTAIWTGVD EAKMQSYSTI 

       250        260        270        280        290        300 
ANHILNSKSI SNWTFIPDRN SSYILLHSVN SFARRLFIDK HPVDISDVFI HTMGTTISGD 

       310        320        330        340        350        360 
NIGKNFTFSM RINDTSNEVT GRVLISRDEL RKVPSPSQVI SIAFPTIGAI LEASLLENVT 

       370        380        390        400        410        420 
VNGLVLSAIL PKELKRISLI FEKISKSEER RTQCVGWHSV ENRWDQQACK MIQENSQQAV 

       430        440        450        460        470        480 
CKCRPSKLFT SFSILMSPHI LESLILTYIT YVGLGISICS LILCLSIEVL VWSQVTKTEI 

       490        500        510        520        530        540 
TYLRHVCIVN IAATLLMADV WFIVASFLSG PITHHKGCVA ATFFVHFFYL SVFFWMLAKA 

       550        560        570        580        590        600 
LLILYGIMIV FHTLPKSVLV ASLFSVGYGC PLAIAAITVA ATEPGKGYLR PEICWLNWDM 

       610        620        630        640        650        660 
TKALLAFVIP ALAIVVVNLI TVTLVIVKTQ RAAIGNSMFQ EVRAIVRISK NIAILTPLLG 

       670        680        690        700 
LTWGFGVATV IDDRSLAFHI IFSLLNAFQV SPDASDQVQS ERIHEDVL 

« Hide

Isoform 2 [UniParc].

Checksum: 49D59F70D13B0500
Show »

FASTA64271,555

References

« Hide 'large scale' references
[1]"There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]"Complete coding sequence of GPR111."
Bonner T.I., Kauffman D., Nagle J.W.
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-467.
Tissue: Testis.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 293-708.
[6]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 326-487 (ISOFORM 1).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY140953 mRNA. Translation: AAN46667.1.
AB065684 Genomic DNA. Translation: BAC05907.1. Sequence problems.
DQ315369 mRNA. Translation: ABC41928.1.
AL356421 Genomic DNA. Translation: CAI15578.1.
AB083617 Genomic DNA. Translation: BAB89330.1.
AY255612 mRNA. Translation: AAO85124.1.
RefSeqNP_722581.4. NM_153839.6. [Q8IZF7-2]
UniGeneHs.724860.

3D structure databases

ProteinModelPortalQ8IZF7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000381727.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8IZF7.

Polymorphism databases

DMDM59797952.

Proteomic databases

PaxDbQ8IZF7.
PRIDEQ8IZF7.

Protocols and materials databases

DNASU222611.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296862; ENSP00000296862; ENSG00000164393. [Q8IZF7-1]
ENST00000398742; ENSP00000381727; ENSG00000164393. [Q8IZF7-2]
ENST00000467205; ENSP00000425269; ENSG00000164393. [Q8IZF7-2]
GeneID222611.
KEGGhsa:222611.
UCSCuc003oyy.3. human. [Q8IZF7-2]
uc010jzj.1. human. [Q8IZF7-1]

Organism-specific databases

CTD222611.
GeneCardsGC06P047624.
HGNCHGNC:18991. GPR111.
HPAHPA035507.
neXtProtNX_Q8IZF7.
PharmGKBPA134984088.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313007.
HOGENOMHOG000112762.
HOVERGENHBG051768.
InParanoidQ8IZF7.
KOK08454.
OMAILIVFHT.
PhylomeDBQ8IZF7.
TreeFamTF316380.

Gene expression databases

ArrayExpressQ8IZF7.
BgeeQ8IZF7.
CleanExHS_GPR111.
GenevestigatorQ8IZF7.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PROSITEPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR111.
GenomeRNAi222611.
NextBio91635.
PROQ8IZF7.

Entry information

Entry nameGP111_HUMAN
AccessionPrimary (citable) accession number: Q8IZF7
Secondary accession number(s): Q2PNZ1 expand/collapse secondary AC list , Q86SL6, Q8NGU5, Q8TDT5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries