Q8IZF7 (GP111_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 111

Alternative name(s):
G-protein coupled receptor PGR20

Gene names

Name:	GPR111
Synonyms:	PGR20

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	708 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain.
Sequence caution	The sequence BAC05907.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement PubMed 15203201. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15203201. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZF7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZF7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     69-92: PSPNAVSSDQVHCSAGCTHRKCGW → MTHILLLYYLVFLLPTESCRTLYQ
     690-708: VSPDASDQVQSERIHEDVL → GFFILVFGTILDPKIREALKG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 708	708	Probable G-protein coupled receptor 111		PRO_0000070334
Regions
	Topological domain	1 – 451	451	Extracellular Potential
	Transmembrane	452 – 472	21	Helical; Name=1; Potential
	Topological domain	473 – 487	15	Cytoplasmic Potential
	Transmembrane	488 – 508	21	Helical; Name=2; Potential
	Topological domain	509 – 530	22	Extracellular Potential
	Transmembrane	531 – 551	21	Helical; Name=3; Potential
	Topological domain	552 – 557	6	Cytoplasmic Potential
	Transmembrane	558 – 578	21	Helical; Name=4; Potential
	Topological domain	579 – 606	28	Extracellular Potential
	Transmembrane	607 – 627	21	Helical; Name=5; Potential
	Topological domain	628 – 650	23	Cytoplasmic Potential
	Transmembrane	651 – 671	21	Helical; Name=6; Potential
	Topological domain	672 – 674	3	Extracellular Potential
	Transmembrane	675 – 695	21	Helical; Name=7; Potential
	Topological domain	696 – 708	13	Cytoplasmic Potential
	Domain	391 – 441	51	GPS
Amino acid modifications
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Glycosylation	252	1	N-linked (GlcNAc...) Potential
	Glycosylation	260	1	N-linked (GlcNAc...) Potential
	Glycosylation	305	1	N-linked (GlcNAc...) Potential
	Glycosylation	313	1	N-linked (GlcNAc...) Potential
	Glycosylation	358	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 68	68	Missing in isoform 2.		VSP_040379
	Alternative sequence	69 – 92	24	PSPNA…RKCGW → MTHILLLYYLVFLLPTESCR TLYQ in isoform 2.		VSP_040380
	Alternative sequence	690 – 708	19	VSPDA…HEDVL → GFFILVFGTILDPKIREALK G in isoform 2.		VSP_040381
	Natural variant	148	1	Q → R. Corresponds to variant rs6907125 [ dbSNP | Ensembl ].		VAR_024473
	Natural variant	467	1	I → V. Ref.3 Corresponds to variant rs9381594 [ dbSNP | Ensembl ].		VAR_024474
Experimental info
	Sequence conflict	427	1	K → E in ABC41928. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 3DE541DD1D723966	FASTA	708	78,569
	10 20 30 40 50 60 MGLTAYGNRR VQPGELPFGA NLTLIHTRAQ PVICSKLLLT KRVSPISFFL SKFQNSWGED 70 80 90 100 110 120 GWVQLDQLPS PNAVSSDQVH CSAGCTHRKC GWAASKSKEK VPARPHGVCD GVCTDYSQCT 130 140 150 160 170 180 QPCPPDTQGN MGFSCRQKTW HKITDTCQTL NALNIFEEDS RLVQPFEDNI KISVYTGKSE 190 200 210 220 230 240 TITDMLLQKC PTDLSCVIRN IQQSPWIPGN IAVIVQLLHN ISTAIWTGVD EAKMQSYSTI 250 260 270 280 290 300 ANHILNSKSI SNWTFIPDRN SSYILLHSVN SFARRLFIDK HPVDISDVFI HTMGTTISGD 310 320 330 340 350 360 NIGKNFTFSM RINDTSNEVT GRVLISRDEL RKVPSPSQVI SIAFPTIGAI LEASLLENVT 370 380 390 400 410 420 VNGLVLSAIL PKELKRISLI FEKISKSEER RTQCVGWHSV ENRWDQQACK MIQENSQQAV 430 440 450 460 470 480 CKCRPSKLFT SFSILMSPHI LESLILTYIT YVGLGISICS LILCLSIEVL VWSQVTKTEI 490 500 510 520 530 540 TYLRHVCIVN IAATLLMADV WFIVASFLSG PITHHKGCVA ATFFVHFFYL SVFFWMLAKA 550 560 570 580 590 600 LLILYGIMIV FHTLPKSVLV ASLFSVGYGC PLAIAAITVA ATEPGKGYLR PEICWLNWDM 610 620 630 640 650 660 TKALLAFVIP ALAIVVVNLI TVTLVIVKTQ RAAIGNSMFQ EVRAIVRISK NIAILTPLLG 670 680 690 700 LTWGFGVATV IDDRSLAFHI IFSLLNAFQV SPDASDQVQS ERIHEDVL
	Isoform 2 [UniParc]. Checksum: 49D59F70D13B0500	FASTA	642	71,555
	10 20 30 40 50 60 MTHILLLYYL VFLLPTESCR TLYQAASKSK EKVPARPHGV CDGVCTDYSQ CTQPCPPDTQ 70 80 90 100 110 120 GNMGFSCRQK TWHKITDTCQ TLNALNIFEE DSRLVQPFED NIKISVYTGK SETITDMLLQ 130 140 150 160 170 180 KCPTDLSCVI RNIQQSPWIP GNIAVIVQLL HNISTAIWTG VDEAKMQSYS TIANHILNSK 190 200 210 220 230 240 SISNWTFIPD RNSSYILLHS VNSFARRLFI DKHPVDISDV FIHTMGTTIS GDNIGKNFTF 250 260 270 280 290 300 SMRINDTSNE VTGRVLISRD ELRKVPSPSQ VISIAFPTIG AILEASLLEN VTVNGLVLSA 310 320 330 340 350 360 ILPKELKRIS LIFEKISKSE ERRTQCVGWH SVENRWDQQA CKMIQENSQQ AVCKCRPSKL 370 380 390 400 410 420 FTSFSILMSP HILESLILTY ITYVGLGISI CSLILCLSIE VLVWSQVTKT EITYLRHVCI 430 440 450 460 470 480 VNIAATLLMA DVWFIVASFL SGPITHHKGC VAATFFVHFF YLSVFFWMLA KALLILYGIM 490 500 510 520 530 540 IVFHTLPKSV LVASLFSVGY GCPLAIAAIT VAATEPGKGY LRPEICWLNW DMTKALLAFV 550 560 570 580 590 600 IPALAIVVVN LITVTLVIVK TQRAAIGNSM FQEVRAIVRI SKNIAILTPL LGLTWGFGVA 610 620 630 640 TVIDDRSLAF HIIFSLLNAF QGFFILVFGT ILDPKIREAL KG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini." Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B. Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]	"Complete coding sequence of GPR111." Bonner T.I., Kauffman D., Nagle J.W. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-467. Tissue: Testis.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 293-708.
[6]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 326-487 (ISOFORM 1).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY140953 mRNA. Translation: AAN46667.1. AB065684 Genomic DNA. Translation: BAC05907.1. Sequence problems. DQ315369 mRNA. Translation: ABC41928.1. AL356421 Genomic DNA. Translation: CAI15578.1. AB083617 Genomic DNA. Translation: BAB89330.1. AY255612 mRNA. Translation: AAO85124.1.
IPI	IPI00218001. IPI00874243.
RefSeq	NP_722581.4. NM_153839.6.
UniGene	Hs.724860.
3D structure databases
ProteinModelPortal	Q8IZF7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000381727.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8IZF7.
Polymorphism databases
DMDM	59797952.
Proteomic databases
PaxDb	Q8IZF7.
PRIDE	Q8IZF7.
Protocols and materials databases
DNASU	222611.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296862; ENSP00000296862; ENSG00000164393. ENST00000398742; ENSP00000381727; ENSG00000164393. ENST00000467205; ENSP00000425269; ENSG00000164393.
GeneID	222611.
KEGG	hsa:222611.
UCSC	uc003oyy.3. human. uc010jzj.1. human.
Organism-specific databases
CTD	222611.
GeneCards	GC06P047624.
HGNC	HGNC:18991. GPR111.
HPA	HPA035507.
neXtProt	NX_Q8IZF7.
PharmGKB	PA134984088.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG313007.
HOGENOM	HOG000112762.
HOVERGEN	HBG051768.
InParanoid	Q8IZF7.
KO	K08454.
OMA	NWTFIPE.
PhylomeDB	Q8IZF7.
Gene expression databases
ArrayExpress	Q8IZF7.
Bgee	Q8IZF7.
CleanEx	HS_GPR111.
Genevestigator	Q8IZF7.
GermOnline	ENSG00000164393. Homo sapiens.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR000832. GPCR_2_secretin-like. IPR000203. GPS_dom. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN.
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	222611.
NextBio	91635.

Entry information

Entry name

GP111_HUMAN

Accession

Primary (citable) accession number: Q8IZF7
Secondary accession number(s): Q2PNZ1 , Q86SL6, Q8NGU5, Q8TDT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.