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Q8IZF7

- GP111_HUMAN

UniProt

Q8IZF7 - GP111_HUMAN

Protein

Probable G-protein coupled receptor 111

Gene

GPR111

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 111
    Alternative name(s):
    G-protein coupled receptor PGR20
    Gene namesi
    Name:GPR111
    Synonyms:PGR20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:18991. GPR111.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134984088.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 708708Probable G-protein coupled receptor 111PRO_0000070334Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi358 – 3581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8IZF7.
    PRIDEiQ8IZF7.

    PTM databases

    PhosphoSiteiQ8IZF7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IZF7.
    BgeeiQ8IZF7.
    CleanExiHS_GPR111.
    GenevestigatoriQ8IZF7.

    Organism-specific databases

    HPAiHPA035507.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000381727.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZF7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 451451ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini473 – 48715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini509 – 53022ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini552 – 5576CytoplasmicSequence Analysis
    Topological domaini579 – 60628ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini628 – 65023CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini672 – 6743ExtracellularSequence Analysis
    Topological domaini696 – 70813CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei452 – 47221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei488 – 50821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei531 – 55121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei558 – 57821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei607 – 62721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei651 – 67121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei675 – 69521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini391 – 44151GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG313007.
    HOGENOMiHOG000112762.
    HOVERGENiHBG051768.
    InParanoidiQ8IZF7.
    KOiK08454.
    OMAiILIVFHT.
    PhylomeDBiQ8IZF7.
    TreeFamiTF316380.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IZF7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLTAYGNRR VQPGELPFGA NLTLIHTRAQ PVICSKLLLT KRVSPISFFL    50
    SKFQNSWGED GWVQLDQLPS PNAVSSDQVH CSAGCTHRKC GWAASKSKEK 100
    VPARPHGVCD GVCTDYSQCT QPCPPDTQGN MGFSCRQKTW HKITDTCQTL 150
    NALNIFEEDS RLVQPFEDNI KISVYTGKSE TITDMLLQKC PTDLSCVIRN 200
    IQQSPWIPGN IAVIVQLLHN ISTAIWTGVD EAKMQSYSTI ANHILNSKSI 250
    SNWTFIPDRN SSYILLHSVN SFARRLFIDK HPVDISDVFI HTMGTTISGD 300
    NIGKNFTFSM RINDTSNEVT GRVLISRDEL RKVPSPSQVI SIAFPTIGAI 350
    LEASLLENVT VNGLVLSAIL PKELKRISLI FEKISKSEER RTQCVGWHSV 400
    ENRWDQQACK MIQENSQQAV CKCRPSKLFT SFSILMSPHI LESLILTYIT 450
    YVGLGISICS LILCLSIEVL VWSQVTKTEI TYLRHVCIVN IAATLLMADV 500
    WFIVASFLSG PITHHKGCVA ATFFVHFFYL SVFFWMLAKA LLILYGIMIV 550
    FHTLPKSVLV ASLFSVGYGC PLAIAAITVA ATEPGKGYLR PEICWLNWDM 600
    TKALLAFVIP ALAIVVVNLI TVTLVIVKTQ RAAIGNSMFQ EVRAIVRISK 650
    NIAILTPLLG LTWGFGVATV IDDRSLAFHI IFSLLNAFQV SPDASDQVQS 700
    ERIHEDVL 708
    Length:708
    Mass (Da):78,569
    Last modified:March 1, 2003 - v1
    Checksum:i3DE541DD1D723966
    GO
    Isoform 2 (identifier: Q8IZF7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-68: Missing.
         69-92: PSPNAVSSDQVHCSAGCTHRKCGW → MTHILLLYYLVFLLPTESCRTLYQ
         690-708: VSPDASDQVQSERIHEDVL → GFFILVFGTILDPKIREALKG

    Show »
    Length:642
    Mass (Da):71,555
    Checksum:i49D59F70D13B0500
    GO

    Sequence cautioni

    The sequence BAC05907.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti427 – 4271K → E in ABC41928. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti148 – 1481Q → R.
    Corresponds to variant rs6907125 [ dbSNP | Ensembl ].
    VAR_024473
    Natural varianti467 – 4671I → V.1 Publication
    Corresponds to variant rs9381594 [ dbSNP | Ensembl ].
    VAR_024474

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6868Missing in isoform 2. 1 PublicationVSP_040379Add
    BLAST
    Alternative sequencei69 – 9224PSPNA…RKCGW → MTHILLLYYLVFLLPTESCR TLYQ in isoform 2. 1 PublicationVSP_040380Add
    BLAST
    Alternative sequencei690 – 70819VSPDA…HEDVL → GFFILVFGTILDPKIREALK G in isoform 2. 1 PublicationVSP_040381Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY140953 mRNA. Translation: AAN46667.1.
    AB065684 Genomic DNA. Translation: BAC05907.1. Sequence problems.
    DQ315369 mRNA. Translation: ABC41928.1.
    AL356421 Genomic DNA. Translation: CAI15578.1.
    AB083617 Genomic DNA. Translation: BAB89330.1.
    AY255612 mRNA. Translation: AAO85124.1.
    RefSeqiNP_722581.4. NM_153839.6. [Q8IZF7-2]
    UniGeneiHs.724860.

    Genome annotation databases

    EnsembliENST00000296862; ENSP00000296862; ENSG00000164393. [Q8IZF7-1]
    ENST00000398742; ENSP00000381727; ENSG00000164393. [Q8IZF7-2]
    ENST00000467205; ENSP00000425269; ENSG00000164393. [Q8IZF7-2]
    GeneIDi222611.
    KEGGihsa:222611.
    UCSCiuc003oyy.3. human. [Q8IZF7-2]
    uc010jzj.1. human. [Q8IZF7-1]

    Polymorphism databases

    DMDMi59797952.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY140953 mRNA. Translation: AAN46667.1 .
    AB065684 Genomic DNA. Translation: BAC05907.1 . Sequence problems.
    DQ315369 mRNA. Translation: ABC41928.1 .
    AL356421 Genomic DNA. Translation: CAI15578.1 .
    AB083617 Genomic DNA. Translation: BAB89330.1 .
    AY255612 mRNA. Translation: AAO85124.1 .
    RefSeqi NP_722581.4. NM_153839.6. [Q8IZF7-2 ]
    UniGenei Hs.724860.

    3D structure databases

    ProteinModelPortali Q8IZF7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000381727.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8IZF7.

    Polymorphism databases

    DMDMi 59797952.

    Proteomic databases

    PaxDbi Q8IZF7.
    PRIDEi Q8IZF7.

    Protocols and materials databases

    DNASUi 222611.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296862 ; ENSP00000296862 ; ENSG00000164393 . [Q8IZF7-1 ]
    ENST00000398742 ; ENSP00000381727 ; ENSG00000164393 . [Q8IZF7-2 ]
    ENST00000467205 ; ENSP00000425269 ; ENSG00000164393 . [Q8IZF7-2 ]
    GeneIDi 222611.
    KEGGi hsa:222611.
    UCSCi uc003oyy.3. human. [Q8IZF7-2 ]
    uc010jzj.1. human. [Q8IZF7-1 ]

    Organism-specific databases

    CTDi 222611.
    GeneCardsi GC06P047624.
    HGNCi HGNC:18991. GPR111.
    HPAi HPA035507.
    neXtProti NX_Q8IZF7.
    PharmGKBi PA134984088.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313007.
    HOGENOMi HOG000112762.
    HOVERGENi HBG051768.
    InParanoidi Q8IZF7.
    KOi K08454.
    OMAi ILIVFHT.
    PhylomeDBi Q8IZF7.
    TreeFami TF316380.

    Miscellaneous databases

    GeneWikii GPR111.
    GenomeRNAii 222611.
    NextBioi 91635.
    PROi Q8IZF7.

    Gene expression databases

    ArrayExpressi Q8IZF7.
    Bgeei Q8IZF7.
    CleanExi HS_GPR111.
    Genevestigatori Q8IZF7.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
      Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
      Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    3. "Complete coding sequence of GPR111."
      Bonner T.I., Kauffman D., Nagle J.W.
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-467.
      Tissue: Testis.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 293-708.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 326-487 (ISOFORM 1).

    Entry informationi

    Entry nameiGP111_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZF7
    Secondary accession number(s): Q2PNZ1
    , Q86SL6, Q8NGU5, Q8TDT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3