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Q8IZF7

- GP111_HUMAN

UniProt

Q8IZF7 - GP111_HUMAN

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Protein
Probable G-protein coupled receptor 111
Gene
GPR111, PGR20
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 111
Alternative name(s):
G-protein coupled receptor PGR20
Gene namesi
Name:GPR111
Synonyms:PGR20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:18991. GPR111.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 451451Extracellular Reviewed prediction
Add
BLAST
Transmembranei452 – 47221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini473 – 48715Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei488 – 50821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini509 – 53022Extracellular Reviewed prediction
Add
BLAST
Transmembranei531 – 55121Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini552 – 5576Cytoplasmic Reviewed prediction
Transmembranei558 – 57821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini579 – 60628Extracellular Reviewed prediction
Add
BLAST
Transmembranei607 – 62721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini628 – 65023Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei651 – 67121Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini672 – 6743Extracellular Reviewed prediction
Transmembranei675 – 69521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini696 – 70813Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984088.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Probable G-protein coupled receptor 111
PRO_0000070334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi252 – 2521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi305 – 3051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi313 – 3131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi358 – 3581N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZF7.
PRIDEiQ8IZF7.

PTM databases

PhosphoSiteiQ8IZF7.

Expressioni

Gene expression databases

ArrayExpressiQ8IZF7.
BgeeiQ8IZF7.
CleanExiHS_GPR111.
GenevestigatoriQ8IZF7.

Organism-specific databases

HPAiHPA035507.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381727.

Structurei

3D structure databases

ProteinModelPortaliQ8IZF7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini391 – 44151GPS
Add
BLAST

Sequence similaritiesi

Contains 1 GPS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313007.
HOGENOMiHOG000112762.
HOVERGENiHBG051768.
InParanoidiQ8IZF7.
KOiK08454.
OMAiILIVFHT.
PhylomeDBiQ8IZF7.
TreeFamiTF316380.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZF7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLTAYGNRR VQPGELPFGA NLTLIHTRAQ PVICSKLLLT KRVSPISFFL    50
SKFQNSWGED GWVQLDQLPS PNAVSSDQVH CSAGCTHRKC GWAASKSKEK 100
VPARPHGVCD GVCTDYSQCT QPCPPDTQGN MGFSCRQKTW HKITDTCQTL 150
NALNIFEEDS RLVQPFEDNI KISVYTGKSE TITDMLLQKC PTDLSCVIRN 200
IQQSPWIPGN IAVIVQLLHN ISTAIWTGVD EAKMQSYSTI ANHILNSKSI 250
SNWTFIPDRN SSYILLHSVN SFARRLFIDK HPVDISDVFI HTMGTTISGD 300
NIGKNFTFSM RINDTSNEVT GRVLISRDEL RKVPSPSQVI SIAFPTIGAI 350
LEASLLENVT VNGLVLSAIL PKELKRISLI FEKISKSEER RTQCVGWHSV 400
ENRWDQQACK MIQENSQQAV CKCRPSKLFT SFSILMSPHI LESLILTYIT 450
YVGLGISICS LILCLSIEVL VWSQVTKTEI TYLRHVCIVN IAATLLMADV 500
WFIVASFLSG PITHHKGCVA ATFFVHFFYL SVFFWMLAKA LLILYGIMIV 550
FHTLPKSVLV ASLFSVGYGC PLAIAAITVA ATEPGKGYLR PEICWLNWDM 600
TKALLAFVIP ALAIVVVNLI TVTLVIVKTQ RAAIGNSMFQ EVRAIVRISK 650
NIAILTPLLG LTWGFGVATV IDDRSLAFHI IFSLLNAFQV SPDASDQVQS 700
ERIHEDVL 708
Length:708
Mass (Da):78,569
Last modified:March 1, 2003 - v1
Checksum:i3DE541DD1D723966
GO
Isoform 2 (identifier: Q8IZF7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     69-92: PSPNAVSSDQVHCSAGCTHRKCGW → MTHILLLYYLVFLLPTESCRTLYQ
     690-708: VSPDASDQVQSERIHEDVL → GFFILVFGTILDPKIREALKG

Show »
Length:642
Mass (Da):71,555
Checksum:i49D59F70D13B0500
GO

Sequence cautioni

The sequence BAC05907.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti148 – 1481Q → R.
Corresponds to variant rs6907125 [ dbSNP | Ensembl ].
VAR_024473
Natural varianti467 – 4671I → V.1 Publication
Corresponds to variant rs9381594 [ dbSNP | Ensembl ].
VAR_024474

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6868Missing in isoform 2.
VSP_040379Add
BLAST
Alternative sequencei69 – 9224PSPNA…RKCGW → MTHILLLYYLVFLLPTESCR TLYQ in isoform 2.
VSP_040380Add
BLAST
Alternative sequencei690 – 70819VSPDA…HEDVL → GFFILVFGTILDPKIREALK G in isoform 2.
VSP_040381Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti427 – 4271K → E in ABC41928. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY140953 mRNA. Translation: AAN46667.1.
AB065684 Genomic DNA. Translation: BAC05907.1. Sequence problems.
DQ315369 mRNA. Translation: ABC41928.1.
AL356421 Genomic DNA. Translation: CAI15578.1.
AB083617 Genomic DNA. Translation: BAB89330.1.
AY255612 mRNA. Translation: AAO85124.1.
RefSeqiNP_722581.4. NM_153839.6. [Q8IZF7-2]
UniGeneiHs.724860.

Genome annotation databases

EnsembliENST00000296862; ENSP00000296862; ENSG00000164393. [Q8IZF7-1]
ENST00000398742; ENSP00000381727; ENSG00000164393. [Q8IZF7-2]
ENST00000467205; ENSP00000425269; ENSG00000164393. [Q8IZF7-2]
GeneIDi222611.
KEGGihsa:222611.
UCSCiuc003oyy.3. human. [Q8IZF7-2]
uc010jzj.1. human. [Q8IZF7-1]

Polymorphism databases

DMDMi59797952.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY140953 mRNA. Translation: AAN46667.1 .
AB065684 Genomic DNA. Translation: BAC05907.1 . Sequence problems.
DQ315369 mRNA. Translation: ABC41928.1 .
AL356421 Genomic DNA. Translation: CAI15578.1 .
AB083617 Genomic DNA. Translation: BAB89330.1 .
AY255612 mRNA. Translation: AAO85124.1 .
RefSeqi NP_722581.4. NM_153839.6. [Q8IZF7-2 ]
UniGenei Hs.724860.

3D structure databases

ProteinModelPortali Q8IZF7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000381727.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8IZF7.

Polymorphism databases

DMDMi 59797952.

Proteomic databases

PaxDbi Q8IZF7.
PRIDEi Q8IZF7.

Protocols and materials databases

DNASUi 222611.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296862 ; ENSP00000296862 ; ENSG00000164393 . [Q8IZF7-1 ]
ENST00000398742 ; ENSP00000381727 ; ENSG00000164393 . [Q8IZF7-2 ]
ENST00000467205 ; ENSP00000425269 ; ENSG00000164393 . [Q8IZF7-2 ]
GeneIDi 222611.
KEGGi hsa:222611.
UCSCi uc003oyy.3. human. [Q8IZF7-2 ]
uc010jzj.1. human. [Q8IZF7-1 ]

Organism-specific databases

CTDi 222611.
GeneCardsi GC06P047624.
HGNCi HGNC:18991. GPR111.
HPAi HPA035507.
neXtProti NX_Q8IZF7.
PharmGKBi PA134984088.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313007.
HOGENOMi HOG000112762.
HOVERGENi HBG051768.
InParanoidi Q8IZF7.
KOi K08454.
OMAi ILIVFHT.
PhylomeDBi Q8IZF7.
TreeFami TF316380.

Miscellaneous databases

GeneWikii GPR111.
GenomeRNAii 222611.
NextBioi 91635.
PROi Q8IZF7.

Gene expression databases

ArrayExpressi Q8IZF7.
Bgeei Q8IZF7.
CleanExi HS_GPR111.
Genevestigatori Q8IZF7.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
    Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
    Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. "Complete coding sequence of GPR111."
    Bonner T.I., Kauffman D., Nagle J.W.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT VAL-467.
    Tissue: Testis.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 293-708.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 326-487 (ISOFORM 1).

Entry informationi

Entry nameiGP111_HUMAN
AccessioniPrimary (citable) accession number: Q8IZF7
Secondary accession number(s): Q2PNZ1
, Q86SL6, Q8NGU5, Q8TDT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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