Q8IZF6 (GP112_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 112

Gene names

Name:

GPR112

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3080 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma. Ref.5
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement PubMed 15203201. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15203201. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZF6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZF6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     2243-2381: Missing.
     2593-2637: Missing.
     2979-3012: Missing.
     3069-3080: DDFDKDPYCSSP → APELSALHVVASEPTTG

Isoform 3 (identifier: Q8IZF6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: D → V
     25-229: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 3080	3053	Probable G-protein coupled receptor 112		PRO_0000070335
Regions
	Topological domain	28 – 2741	2714	Extracellular Potential
	Transmembrane	2742 – 2762	21	Helical; Name=1; Potential
	Topological domain	2763 – 2778	16	Cytoplasmic Potential
	Transmembrane	2779 – 2799	21	Helical; Name=2; Potential
	Topological domain	2800 – 2805	6	Extracellular Potential
	Transmembrane	2806 – 2826	21	Helical; Name=3; Potential
	Topological domain	2827 – 2848	22	Cytoplasmic Potential
	Transmembrane	2849 – 2869	21	Helical; Name=4; Potential
	Topological domain	2870 – 2892	23	Extracellular Potential
	Transmembrane	2893 – 2913	21	Helical; Name=5; Potential
	Topological domain	2914 – 2942	29	Cytoplasmic Potential
	Transmembrane	2943 – 2963	21	Helical; Name=6; Potential
	Topological domain	2964 – 2965	2	Extracellular Potential
	Transmembrane	2966 – 2986	21	Helical; Name=7; Potential
	Topological domain	2987 – 3080	94	Cytoplasmic Potential
	Domain	2682 – 2733	52	GPS
Amino acid modifications
	Glycosylation	233	1	N-linked (GlcNAc...) Potential
	Glycosylation	487	1	N-linked (GlcNAc...) Potential
	Glycosylation	836	1	N-linked (GlcNAc...) Potential
	Glycosylation	899	1	N-linked (GlcNAc...) Potential
	Glycosylation	1020	1	N-linked (GlcNAc...) Potential
	Glycosylation	1519	1	N-linked (GlcNAc...) Potential
	Glycosylation	2361	1	N-linked (GlcNAc...) Potential
	Glycosylation	2640	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 63	63	Missing in isoform 2.		VSP_038170
	Alternative sequence	24	1	D → V in isoform 3.		VSP_038171
	Alternative sequence	25 – 229	205	Missing in isoform 3.		VSP_038172
	Alternative sequence	2243 – 2381	139	Missing in isoform 2.		VSP_038173
	Alternative sequence	2593 – 2637	45	Missing in isoform 2.		VSP_038174
	Alternative sequence	2979 – 3012	34	Missing in isoform 2.		VSP_038175
	Alternative sequence	3069 – 3080	12	DDFDK…YCSSP → APELSALHVVASEPTTG in isoform 2.		VSP_038176
	Natural variant	276	1	I → M. Ref.2 Corresponds to variant rs4829829 [ dbSNP | Ensembl ].		VAR_055929
	Natural variant	368	1	P → H. Ref.2 Corresponds to variant rs5930931 [ dbSNP | Ensembl ].		VAR_059329
	Natural variant	1213	1	T → N. Corresponds to variant rs4829830 [ dbSNP | Ensembl ].		VAR_059330
	Natural variant	1540	1	S → P. Corresponds to variant rs912002 [ dbSNP | Ensembl ].		VAR_059331
	Natural variant	1791	1	F → L. Corresponds to variant rs5930932 [ dbSNP | Ensembl ].		VAR_059332
Experimental info
	Sequence conflict	229	1	Missing in AAN46668. Ref.1
	Sequence conflict	2426	1	Missing in AAN46668. Ref.1
	Sequence conflict	2694	1	Missing in AAN46668. Ref.1
	Sequence conflict	2769	1	Missing in AAN46668. Ref.1
	Sequence conflict	2885	1	Missing in AAN46668. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 3449BC820B251BD3	FASTA	3,080	333,368
	10 20 30 40 50 60 MKEHIIYQKL YGLILMSSFI FLSDTLSLKG KKLDFFGRGD TYVSLIDTIP ELSRFTACID 70 80 90 100 110 120 LVFMDDNSRY WMAFSYITNN ALLGREDIDL GLAGDHQQLI LYRLGKTFSI RHHLASFQWH 130 140 150 160 170 180 TICLIWDGVK GKLELFLNKE RILEVTDQPH NLTPHGTLFL GHFLKNESSE VKSMMRSFPG 190 200 210 220 230 240 SLYYFQLWDH ILENEEFMKC LDGNIVSWEE DVWLVNKIIP TVDRTLRCFV PENMTIQEKS 250 260 270 280 290 300 TTVSQQIDMT TPSQITGVKP QNTAHSSTLL SQSIPIFATD YTTISYSNTT SPPLETMTAQ 310 320 330 340 350 360 KILKTLVDET ATFAVDVLST SSAISLPTQS ISIDNTTNSM KKTKSPSSES TKTTKMVEAM 370 380 390 400 410 420 ATEIFQPPTP SNFLSTSRFT KNSVVSTTSA IKSQSAVTKT TSLFSTIEST SMSTTPCLKQ 430 440 450 460 470 480 KSTNTGALPI STAGQEFIES TAAGTVPWFT VEKTSPASTH VGTASSFPPE PVLISTAAPV 490 500 510 520 530 540 DSVFPRNQTA FPLATTDMKI AFTVHSLTLP TRLIETTPAP RTAETELTST NFQDVSLPRV 550 560 570 580 590 600 EDAMSTSMSK ETSSKTFSFL TSFSFTGTES VQTVIDAEAT RTALTPEITL ASTVAETMLS 610 620 630 640 650 660 STITGRVYTQ NTPTADGHLL TLMSTRSAST SKAPESGPTS TTDEAAHLFS SNETIWTSRP 670 680 690 700 710 720 DQALLASMNT TTILTFVPNE NFTSAFHENT TYTEYLSATT NITPLKASPE GKGTTANDAT 730 740 750 760 770 780 TARYTTAVSK LTSPWFANFS IVSGTTSITN MPEFKLTTLL LKTIPMSTKP ANELPLTPRE 790 800 810 820 830 840 TVVPSVDIIS TLACIQPNFS TEESASETTQ TEINGAIVFG GTTTPVPKSA TTQRLNATVT 850 860 870 880 890 900 RKEATSHYLM RKSTIAAVAE VSPFSTMLEV TDESAQRVTA SVTVSSFPDI EKLSTPLDNK 910 920 930 940 950 960 TATTEVRESW LLTKLVKTTP RSSYNEMTEM FNFNHTYVAH WTSETSEGIS AGSPTSGSTH 970 980 990 1000 1010 1020 IFGEPLGAST TRISETSFST TPTDRTATSL SDGILPPQPT AAHSSATPVP VTHMFSLPVN 1030 1040 1050 1060 1070 1080 GSSVVAEETE VTMSEPSTLA RAFSTSVLSD VSNLSSTTMT TALVPPLDQT ASTTIVIVPT 1090 1100 1110 1120 1130 1140 HGDLIRTTSE ATVISVRKTS MAVPSLTETP FHSLRLSTPV TAKAETTLFS TSVDTVTPST 1150 1160 1170 1180 1190 1200 HTLVCSKPPP DNIPPASSTH VISTTSTPEA TQPISQVEET STYALSFPYT FSGGGVVASL 1210 1220 1230 1240 1250 1260 ATGTTETSVV DETTPSHISA NKLTTSVNSH ISSSATYRVH TPVSIQLVTS TSVLSSDKDQ 1270 1280 1290 1300 1310 1320 MTISLGKTPR TMEVTEMSPS KNSFISYSRG TPSLEMTDTG FPETTKISSH QTHSPSEIPL 1330 1340 1350 1360 1370 1380 GTPSDGNLAS SPTSGSTQIT PTLTSSNTVG VHIPEMSTSL GKTALPSQAL TITTFLCPEK 1390 1400 1410 1420 1430 1440 ESTSALPAYT PRTVEMIVNS TYVTHSVSYG QDTSFVDTTT SSSTRISNPM DINTTFSHLH 1450 1460 1470 1480 1490 1500 SLRTQPEVTS VASFISESTQ TFPESLSLST AGLYNDGFTV LSDRITTAFS VPNVPTMLPR 1510 1520 1530 1540 1550 1560 ESSMATSTPI YQMSSLPVNV TAFTSKKVSD TPPIVITKSS KTMHPGCLKS PCTATSGPMS 1570 1580 1590 1600 1610 1620 EMSSIPVNNS AFTPATVSSD TSTRVGLFST LLSSVTPRTT MTMQTSTLDV TPVIYAGATS 1630 1640 1650 1660 1670 1680 KNKMVSSAFT TEMIEAPSRI TPTTFLSPTE PTLPFVKTVP TTIMAGIVTP FVGTTAFSPL 1690 1700 1710 1720 1730 1740 SSKSTGAISS IPKTTFSPFL SATQQSSQAD EATTLGILSG ITNRSLSTVN SGTGVALTDT 1750 1760 1770 1780 1790 1800 YSRITVPENM LSPTHADSLH TSFNIQVSPS LTSFKSASGP TKNVKTTTNC FSSNTRKMTS 1810 1820 1830 1840 1850 1860 LLEKTSLTNY ATSLNTPVSY PPWTPSSATL PSLTSFVYSP HSTEAEISTP KTSPPPTSQM 1870 1880 1890 1900 1910 1920 VEFPVLGTRM TSSNTQPLLM TSWNIPTAEG SQFPISTTIN VPTSNEMETE TLHLVPGPLS 1930 1940 1950 1960 1970 1980 TFTASQTGLV SKDVMAMSSI PMSGILPNHG LSENPSLSTS LRAITSTLAD VKHTFEKMTT 1990 2000 2010 2020 2030 2040 SVTPGTTLPS ILSGATSGSV ISKSPILTWL LSSLPSGSPP ATVSNAPHVM TSSTVEVSKS 2050 2060 2070 2080 2090 2100 TFLTSDMISA HPFTNLTTLP SATMSTILTR TIPTPTLGGI TTGFPTSLPM SINVTDDIVY 2110 2120 2130 2140 2150 2160 ISTHPEASSR TTITANPRTV SHPSSFSRKT MSPSTTDHTL SVGAMPLPSS TITSSWNRIP 2170 2180 2190 2200 2210 2220 TASSPSTLII PKPTLDSLLN IMTTTSTVPG ASFPLISTGV TYPFTATVSS PISSFFETTW 2230 2240 2250 2260 2270 2280 LDSTPSFLST EASTSPTATK STVSFYNVEM SFSVFVEEPR IPITSVINEF TENSLNSIFQ 2290 2300 2310 2320 2330 2340 NSEFSLATLE TQIKSRDISE EEMVMDRAIL EQREGQEMAT ISYVPYSCVC QVIIKASSSL 2350 2360 2370 2380 2390 2400 ASSELMRKIK SKIHGNFTHG NFTQDQLTLL VNCEHVAVKK LEPGNCKADE TASKYKGTYK 2410 2420 2430 2440 2450 2460 WLLTNPTETA QTRCIKNEDG NATRFCSISI NTGKSQWEKP KFKQCKLLQE LPDKIVDLAN 2470 2480 2490 2500 2510 2520 ITISDENAED VAEHILNLIN ESPALGKEET KIIVSKISDI SQCDEISMNL THVMLQIINV 2530 2540 2550 2560 2570 2580 VLEKQNNSAS DLHEISNEIL RIIERTGHKM EFSGQIANLT VAGLALAVLR GDHTFDGMAF 2590 2600 2610 2620 2630 2640 SIHSYEEGTD PEIFLGNVPV GGILASIYLP KSLTERIPLS NLQTILFNFF GQTSLFKTKN 2650 2660 2670 2680 2690 2700 VTKALTTYVV SASISDDMFI QNLADPVVIT LQHIGGNQNY GQVHCAFWDF ENNNGLGGWN 2710 2720 2730 2740 2750 2760 SSGCKVKETN VNYTICQCDH LTHFGVLMDL SRSTVDSVNE QILALITYTG CGISSIFLGV 2770 2780 2790 2800 2810 2820 AVVTYIAFHK LRKDYPAKIL INLCTALLML NLVFLINSWL SSFQKVGVCI TAAVALHYFL 2830 2840 2850 2860 2870 2880 LVSFTWMGLE AVHMYLALVK VFNIYIPNYI LKFCLVGWGI PAIMVAITVS VKKDLYGTLS 2890 2900 2910 2920 2930 2940 PTTPFCWIKD DSIFYISVVA YFCLIFLMNL SMFCTVLVQL NSVKSQIQKT RRKMILHDLK 2950 2960 2970 2980 2990 3000 GTMSLTFLLG LTWGFAFFAW GPMRNFFLYL FAIFNTLQGF FIFVFHCVMK ESVREQWQIH 3010 3020 3030 3040 3050 3060 LCCGWLRLDN SSDGSSRCQI KVGYKQEGLK KIFEHKLLTP SLKSTATSST FKSLGSAQGT 3070 3080 PSEISFPNDD FDKDPYCSSP
	Isoform 2 [UniParc]. Checksum: B6E45BB089F26D65	FASTA	2,804	301,615
	10 20 30 40 50 60 MDDNSRYWMA FSYITNNALL GREDIDLGLA GDHQQLILYR LGKTFSIRHH LASFQWHTIC 70 80 90 100 110 120 LIWDGVKGKL ELFLNKERIL EVTDQPHNLT PHGTLFLGHF LKNESSEVKS MMRSFPGSLY 130 140 150 160 170 180 YFQLWDHILE NEEFMKCLDG NIVSWEEDVW LVNKIIPTVD RTLRCFVPEN MTIQEKSTTV 190 200 210 220 230 240 SQQIDMTTPS QITGVKPQNT AHSSTLLSQS IPIFATDYTT ISYSNTTSPP LETMTAQKIL 250 260 270 280 290 300 KTLVDETATF AVDVLSTSSA ISLPTQSISI DNTTNSMKKT KSPSSESTKT TKMVEAMATE 310 320 330 340 350 360 IFQPPTPSNF LSTSRFTKNS VVSTTSAIKS QSAVTKTTSL FSTIESTSMS TTPCLKQKST 370 380 390 400 410 420 NTGALPISTA GQEFIESTAA GTVPWFTVEK TSPASTHVGT ASSFPPEPVL ISTAAPVDSV 430 440 450 460 470 480 FPRNQTAFPL ATTDMKIAFT VHSLTLPTRL IETTPAPRTA ETELTSTNFQ DVSLPRVEDA 490 500 510 520 530 540 MSTSMSKETS SKTFSFLTSF SFTGTESVQT VIDAEATRTA LTPEITLAST VAETMLSSTI 550 560 570 580 590 600 TGRVYTQNTP TADGHLLTLM STRSASTSKA PESGPTSTTD EAAHLFSSNE TIWTSRPDQA 610 620 630 640 650 660 LLASMNTTTI LTFVPNENFT SAFHENTTYT EYLSATTNIT PLKASPEGKG TTANDATTAR 670 680 690 700 710 720 YTTAVSKLTS PWFANFSIVS GTTSITNMPE FKLTTLLLKT IPMSTKPANE LPLTPRETVV 730 740 750 760 770 780 PSVDIISTLA CIQPNFSTEE SASETTQTEI NGAIVFGGTT TPVPKSATTQ RLNATVTRKE 790 800 810 820 830 840 ATSHYLMRKS TIAAVAEVSP FSTMLEVTDE SAQRVTASVT VSSFPDIEKL STPLDNKTAT 850 860 870 880 890 900 TEVRESWLLT KLVKTTPRSS YNEMTEMFNF NHTYVAHWTS ETSEGISAGS PTSGSTHIFG 910 920 930 940 950 960 EPLGASTTRI SETSFSTTPT DRTATSLSDG ILPPQPTAAH SSATPVPVTH MFSLPVNGSS 970 980 990 1000 1010 1020 VVAEETEVTM SEPSTLARAF STSVLSDVSN LSSTTMTTAL VPPLDQTAST TIVIVPTHGD 1030 1040 1050 1060 1070 1080 LIRTTSEATV ISVRKTSMAV PSLTETPFHS LRLSTPVTAK AETTLFSTSV DTVTPSTHTL 1090 1100 1110 1120 1130 1140 VCSKPPPDNI PPASSTHVIS TTSTPEATQP ISQVEETSTY ALSFPYTFSG GGVVASLATG 1150 1160 1170 1180 1190 1200 TTETSVVDET TPSHISANKL TTSVNSHISS SATYRVHTPV SIQLVTSTSV LSSDKDQMTI 1210 1220 1230 1240 1250 1260 SLGKTPRTME VTEMSPSKNS FISYSRGTPS LEMTDTGFPE TTKISSHQTH SPSEIPLGTP 1270 1280 1290 1300 1310 1320 SDGNLASSPT SGSTQITPTL TSSNTVGVHI PEMSTSLGKT ALPSQALTIT TFLCPEKEST 1330 1340 1350 1360 1370 1380 SALPAYTPRT VEMIVNSTYV THSVSYGQDT SFVDTTTSSS TRISNPMDIN TTFSHLHSLR 1390 1400 1410 1420 1430 1440 TQPEVTSVAS FISESTQTFP ESLSLSTAGL YNDGFTVLSD RITTAFSVPN VPTMLPRESS 1450 1460 1470 1480 1490 1500 MATSTPIYQM SSLPVNVTAF TSKKVSDTPP IVITKSSKTM HPGCLKSPCT ATSGPMSEMS 1510 1520 1530 1540 1550 1560 SIPVNNSAFT PATVSSDTST RVGLFSTLLS SVTPRTTMTM QTSTLDVTPV IYAGATSKNK 1570 1580 1590 1600 1610 1620 MVSSAFTTEM IEAPSRITPT TFLSPTEPTL PFVKTVPTTI MAGIVTPFVG TTAFSPLSSK 1630 1640 1650 1660 1670 1680 STGAISSIPK TTFSPFLSAT QQSSQADEAT TLGILSGITN RSLSTVNSGT GVALTDTYSR 1690 1700 1710 1720 1730 1740 ITVPENMLSP THADSLHTSF NIQVSPSLTS FKSASGPTKN VKTTTNCFSS NTRKMTSLLE 1750 1760 1770 1780 1790 1800 KTSLTNYATS LNTPVSYPPW TPSSATLPSL TSFVYSPHST EAEISTPKTS PPPTSQMVEF 1810 1820 1830 1840 1850 1860 PVLGTRMTSS NTQPLLMTSW NIPTAEGSQF PISTTINVPT SNEMETETLH LVPGPLSTFT 1870 1880 1890 1900 1910 1920 ASQTGLVSKD VMAMSSIPMS GILPNHGLSE NPSLSTSLRA ITSTLADVKH TFEKMTTSVT 1930 1940 1950 1960 1970 1980 PGTTLPSILS GATSGSVISK SPILTWLLSS LPSGSPPATV SNAPHVMTSS TVEVSKSTFL 1990 2000 2010 2020 2030 2040 TSDMISAHPF TNLTTLPSAT MSTILTRTIP TPTLGGITTG FPTSLPMSIN VTDDIVYIST 2050 2060 2070 2080 2090 2100 HPEASSRTTI TANPRTVSHP SSFSRKTMSP STTDHTLSVG AMPLPSSTIT SSWNRIPTAS 2110 2120 2130 2140 2150 2160 SPSTLIIPKP TLDSLLNIMT TTSTVPGASF PLISTGVTYP FTATVSSPIS SFFETTWLDS 2170 2180 2190 2200 2210 2220 TPSFLSTEAS TSPTATKSTE PGNCKADETA SKYKGTYKWL LTNPTETAQT RCIKNEDGNA 2230 2240 2250 2260 2270 2280 TRFCSISINT GKSQWEKPKF KQCKLLQELP DKIVDLANIT ISDENAEDVA EHILNLINES 2290 2300 2310 2320 2330 2340 PALGKEETKI IVSKISDISQ CDEISMNLTH VMLQIINVVL EKQNNSASDL HEISNEILRI 2350 2360 2370 2380 2390 2400 IERTGHKMEF SGQIANLTVA GLALAVLRGD HTFDGMAFSI HSYEEGTDPE TKNVTKALTT 2410 2420 2430 2440 2450 2460 YVVSASISDD MFIQNLADPV VITLQHIGGN QNYGQVHCAF WDFENNNGLG GWNSSGCKVK 2470 2480 2490 2500 2510 2520 ETNVNYTICQ CDHLTHFGVL MDLSRSTVDS VNEQILALIT YTGCGISSIF LGVAVVTYIA 2530 2540 2550 2560 2570 2580 FHKLRKDYPA KILINLCTAL LMLNLVFLIN SWLSSFQKVG VCITAAVALH YFLLVSFTWM 2590 2600 2610 2620 2630 2640 GLEAVHMYLA LVKVFNIYIP NYILKFCLVG WGIPAIMVAI TVSVKKDLYG TLSPTTPFCW 2650 2660 2670 2680 2690 2700 IKDDSIFYIS VVAYFCLIFL MNLSMFCTVL VQLNSVKSQI QKTRRKMILH DLKGTMSLTF 2710 2720 2730 2740 2750 2760 LLGLTWGFAF FAWGPMRNFF LYLFAIFNTL QDGSSRCQIK VGYKQEGLKK IFEHKLLTPS 2770 2780 2790 2800 LKSTATSSTF KSLGSAQGTP SEISFPNAPE LSALHVVASE PTTG
	Isoform 3 [UniParc]. Checksum: FC26A9AA34552F93	FASTA	2,875	309,429
	10 20 30 40 50 60 MKEHIIYQKL YGLILMSSFI FLSVVPENMT IQEKSTTVSQ QIDMTTPSQI TGVKPQNTAH 70 80 90 100 110 120 SSTLLSQSIP IFATDYTTIS YSNTTSPPLE TMTAQKILKT LVDETATFAV DVLSTSSAIS 130 140 150 160 170 180 LPTQSISIDN TTNSMKKTKS PSSESTKTTK MVEAMATEIF QPPTPSNFLS TSRFTKNSVV 190 200 210 220 230 240 STTSAIKSQS AVTKTTSLFS TIESTSMSTT PCLKQKSTNT GALPISTAGQ EFIESTAAGT 250 260 270 280 290 300 VPWFTVEKTS PASTHVGTAS SFPPEPVLIS TAAPVDSVFP RNQTAFPLAT TDMKIAFTVH 310 320 330 340 350 360 SLTLPTRLIE TTPAPRTAET ELTSTNFQDV SLPRVEDAMS TSMSKETSSK TFSFLTSFSF 370 380 390 400 410 420 TGTESVQTVI DAEATRTALT PEITLASTVA ETMLSSTITG RVYTQNTPTA DGHLLTLMST 430 440 450 460 470 480 RSASTSKAPE SGPTSTTDEA AHLFSSNETI WTSRPDQALL ASMNTTTILT FVPNENFTSA 490 500 510 520 530 540 FHENTTYTEY LSATTNITPL KASPEGKGTT ANDATTARYT TAVSKLTSPW FANFSIVSGT 550 560 570 580 590 600 TSITNMPEFK LTTLLLKTIP MSTKPANELP LTPRETVVPS VDIISTLACI QPNFSTEESA 610 620 630 640 650 660 SETTQTEING AIVFGGTTTP VPKSATTQRL NATVTRKEAT SHYLMRKSTI AAVAEVSPFS 670 680 690 700 710 720 TMLEVTDESA QRVTASVTVS SFPDIEKLST PLDNKTATTE VRESWLLTKL VKTTPRSSYN 730 740 750 760 770 780 EMTEMFNFNH TYVAHWTSET SEGISAGSPT SGSTHIFGEP LGASTTRISE TSFSTTPTDR 790 800 810 820 830 840 TATSLSDGIL PPQPTAAHSS ATPVPVTHMF SLPVNGSSVV AEETEVTMSE PSTLARAFST 850 860 870 880 890 900 SVLSDVSNLS STTMTTALVP PLDQTASTTI VIVPTHGDLI RTTSEATVIS VRKTSMAVPS 910 920 930 940 950 960 LTETPFHSLR LSTPVTAKAE TTLFSTSVDT VTPSTHTLVC SKPPPDNIPP ASSTHVISTT 970 980 990 1000 1010 1020 STPEATQPIS QVEETSTYAL SFPYTFSGGG VVASLATGTT ETSVVDETTP SHISANKLTT 1030 1040 1050 1060 1070 1080 SVNSHISSSA TYRVHTPVSI QLVTSTSVLS SDKDQMTISL GKTPRTMEVT EMSPSKNSFI 1090 1100 1110 1120 1130 1140 SYSRGTPSLE MTDTGFPETT KISSHQTHSP SEIPLGTPSD GNLASSPTSG STQITPTLTS 1150 1160 1170 1180 1190 1200 SNTVGVHIPE MSTSLGKTAL PSQALTITTF LCPEKESTSA LPAYTPRTVE MIVNSTYVTH 1210 1220 1230 1240 1250 1260 SVSYGQDTSF VDTTTSSSTR ISNPMDINTT FSHLHSLRTQ PEVTSVASFI SESTQTFPES 1270 1280 1290 1300 1310 1320 LSLSTAGLYN DGFTVLSDRI TTAFSVPNVP TMLPRESSMA TSTPIYQMSS LPVNVTAFTS 1330 1340 1350 1360 1370 1380 KKVSDTPPIV ITKSSKTMHP GCLKSPCTAT SGPMSEMSSI PVNNSAFTPA TVSSDTSTRV 1390 1400 1410 1420 1430 1440 GLFSTLLSSV TPRTTMTMQT STLDVTPVIY AGATSKNKMV SSAFTTEMIE APSRITPTTF 1450 1460 1470 1480 1490 1500 LSPTEPTLPF VKTVPTTIMA GIVTPFVGTT AFSPLSSKST GAISSIPKTT FSPFLSATQQ 1510 1520 1530 1540 1550 1560 SSQADEATTL GILSGITNRS LSTVNSGTGV ALTDTYSRIT VPENMLSPTH ADSLHTSFNI 1570 1580 1590 1600 1610 1620 QVSPSLTSFK SASGPTKNVK TTTNCFSSNT RKMTSLLEKT SLTNYATSLN TPVSYPPWTP 1630 1640 1650 1660 1670 1680 SSATLPSLTS FVYSPHSTEA EISTPKTSPP PTSQMVEFPV LGTRMTSSNT QPLLMTSWNI 1690 1700 1710 1720 1730 1740 PTAEGSQFPI STTINVPTSN EMETETLHLV PGPLSTFTAS QTGLVSKDVM AMSSIPMSGI 1750 1760 1770 1780 1790 1800 LPNHGLSENP SLSTSLRAIT STLADVKHTF EKMTTSVTPG TTLPSILSGA TSGSVISKSP 1810 1820 1830 1840 1850 1860 ILTWLLSSLP SGSPPATVSN APHVMTSSTV EVSKSTFLTS DMISAHPFTN LTTLPSATMS 1870 1880 1890 1900 1910 1920 TILTRTIPTP TLGGITTGFP TSLPMSINVT DDIVYISTHP EASSRTTITA NPRTVSHPSS 1930 1940 1950 1960 1970 1980 FSRKTMSPST TDHTLSVGAM PLPSSTITSS WNRIPTASSP STLIIPKPTL DSLLNIMTTT 1990 2000 2010 2020 2030 2040 STVPGASFPL ISTGVTYPFT ATVSSPISSF FETTWLDSTP SFLSTEASTS PTATKSTVSF 2050 2060 2070 2080 2090 2100 YNVEMSFSVF VEEPRIPITS VINEFTENSL NSIFQNSEFS LATLETQIKS RDISEEEMVM 2110 2120 2130 2140 2150 2160 DRAILEQREG QEMATISYVP YSCVCQVIIK ASSSLASSEL MRKIKSKIHG NFTHGNFTQD 2170 2180 2190 2200 2210 2220 QLTLLVNCEH VAVKKLEPGN CKADETASKY KGTYKWLLTN PTETAQTRCI KNEDGNATRF 2230 2240 2250 2260 2270 2280 CSISINTGKS QWEKPKFKQC KLLQELPDKI VDLANITISD ENAEDVAEHI LNLINESPAL 2290 2300 2310 2320 2330 2340 GKEETKIIVS KISDISQCDE ISMNLTHVML QIINVVLEKQ NNSASDLHEI SNEILRIIER 2350 2360 2370 2380 2390 2400 TGHKMEFSGQ IANLTVAGLA LAVLRGDHTF DGMAFSIHSY EEGTDPEIFL GNVPVGGILA 2410 2420 2430 2440 2450 2460 SIYLPKSLTE RIPLSNLQTI LFNFFGQTSL FKTKNVTKAL TTYVVSASIS DDMFIQNLAD 2470 2480 2490 2500 2510 2520 PVVITLQHIG GNQNYGQVHC AFWDFENNNG LGGWNSSGCK VKETNVNYTI CQCDHLTHFG 2530 2540 2550 2560 2570 2580 VLMDLSRSTV DSVNEQILAL ITYTGCGISS IFLGVAVVTY IAFHKLRKDY PAKILINLCT 2590 2600 2610 2620 2630 2640 ALLMLNLVFL INSWLSSFQK VGVCITAAVA LHYFLLVSFT WMGLEAVHMY LALVKVFNIY 2650 2660 2670 2680 2690 2700 IPNYILKFCL VGWGIPAIMV AITVSVKKDL YGTLSPTTPF CWIKDDSIFY ISVVAYFCLI 2710 2720 2730 2740 2750 2760 FLMNLSMFCT VLVQLNSVKS QIQKTRRKMI LHDLKGTMSL TFLLGLTWGF AFFAWGPMRN 2770 2780 2790 2800 2810 2820 FFLYLFAIFN TLQGFFIFVF HCVMKESVRE QWQIHLCCGW LRLDNSSDGS SRCQIKVGYK 2830 2840 2850 2860 2870 QEGLKKIFEH KLLTPSLKST ATSSTFKSLG SAQGTPSEIS FPNDDFDKDP YCSSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions." Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B. FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	Bonner T.I., Kauffman D., Nagle J.W., Sloger M., Kozhich O. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-276 AND HIS-368. Tissue: Retina.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-1613 (ISOFORMS 1/2).
[5]	"Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas." Leja J., Essaghir A., Essand M., Wester K., Oeberg K., Toetterman T.H., Lloyd R., Vasmatzis G., Demoulin J.-B., Giandomenico V. Mod. Pathol. 22:261-272(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY140954 mRNA. Translation: AAN46668.1. AY882585 mRNA. Translation: AAW78659.1. AL161778, AL078638, AL136167 Genomic DNA. Translation: CAM21249.1. AL078638, AL136167, AL161778 Genomic DNA. Translation: CAM21580.1. AL136167, AL078638, AL161778 Genomic DNA. Translation: CAM28221.1. AL161778, AL078638, AL136167 Genomic DNA. Translation: CAI40998.2. AL078638, AL136167, AL161778 Genomic DNA. Translation: CAM21579.1. AL136167, AL078638, AL161778 Genomic DNA. Translation: CAM28220.1. AY255581 mRNA. Translation: AAO85093.1.
IPI	IPI00552840. IPI00645561. IPI00853390.
RefSeq	NP_722576.3. NM_153834.3.
UniGene	Hs.381354.
3D structure databases
ProteinModelPortal	Q8IZF6.
ModBase	Search...
Protein family/group databases
MEROPS	S63.017.
GPCRDB	Search...
PTM databases
PhosphoSite	Q8IZF6.
Polymorphism databases
DMDM	259016241.
Proteomic databases
PaxDb	Q8IZF6.
PRIDE	Q8IZF6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000287534; ENSP00000287534; ENSG00000156920. ENST00000370652; ENSP00000359686; ENSG00000156920. ENST00000394141; ENSP00000377697; ENSG00000156920. ENST00000394143; ENSP00000377699; ENSG00000156920. ENST00000412101; ENSP00000416526; ENSG00000156920.
GeneID	139378.
KEGG	hsa:139378.
UCSC	uc004ezu.1. human. uc010nsb.1. human. uc010nsc.1. human.
Organism-specific databases
CTD	139378.
GeneCards	GC0XP135383.
HGNC	HGNC:18992. GPR112.
HPA	HPA035324.
neXtProt	NX_Q8IZF6.
PharmGKB	PA134885132.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000230882.
KO	K08455.
OMA	YFQLWDH.
OrthoDB	EOG4W0XDT.
Gene expression databases
Bgee	Q8IZF6.
CleanEx	HS_GPR112.
Genevestigator	Q8IZF6.
GermOnline	ENSG00000156920. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR017981. GPCR_2-like. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR000203. GPS_dom. IPR001759. Pentaxin. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. PF00354. Pentaxin. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN.
SMART	SM00303. GPS. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS00289. PENTAXIN. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	139378.
NextBio	83952.

Entry information

Entry name

GP112_HUMAN

Accession

Primary (citable) accession number: Q8IZF6
Secondary accession number(s): A2A2J1 , A2A2J2, Q5EGP2, Q86SM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	September 22, 2009
Last modified:	April 3, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.