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Q8IZF6

- GP112_HUMAN

UniProt

Q8IZF6 - GP112_HUMAN

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Protein

Probable G-protein coupled receptor 112

Gene

GPR112

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 112
Gene namesi
Name:GPR112
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:18992. GPR112.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 30803053Probable G-protein coupled receptor 112PRO_0000070335Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi836 – 8361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi899 – 8991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1020 – 10201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1519 – 15191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2361 – 23611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2640 – 26401N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8IZF6.
PaxDbiQ8IZF6.
PRIDEiQ8IZF6.

PTM databases

PhosphoSiteiQ8IZF6.

Expressioni

Tissue specificityi

Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma.1 Publication

Gene expression databases

BgeeiQ8IZF6.
CleanExiHS_GPR112.
GenevestigatoriQ8IZF6.

Organism-specific databases

HPAiHPA035324.

Interactioni

Protein-protein interaction databases

BioGridi126563. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8IZF6.
SMRiQ8IZF6. Positions 2645-2721, 2741-2989.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 27412714ExtracellularSequence AnalysisAdd
BLAST
Topological domaini2763 – 277816CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini2800 – 28056ExtracellularSequence Analysis
Topological domaini2827 – 284822CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini2870 – 289223ExtracellularSequence AnalysisAdd
BLAST
Topological domaini2914 – 294229CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini2964 – 29652ExtracellularSequence Analysis
Topological domaini2987 – 308094CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2742 – 276221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei2779 – 279921Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei2806 – 282621Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei2849 – 286921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei2893 – 291321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei2943 – 296321Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei2966 – 298621Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2682 – 273352GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118787.
HOGENOMiHOG000230882.
InParanoidiQ8IZF6.
KOiK08455.
OMAiYFQLWDH.
OrthoDBiEOG7ZGX28.
PhylomeDBiQ8IZF6.
TreeFamiTF321769.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZF6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEHIIYQKL YGLILMSSFI FLSDTLSLKG KKLDFFGRGD TYVSLIDTIP
60 70 80 90 100
ELSRFTACID LVFMDDNSRY WMAFSYITNN ALLGREDIDL GLAGDHQQLI
110 120 130 140 150
LYRLGKTFSI RHHLASFQWH TICLIWDGVK GKLELFLNKE RILEVTDQPH
160 170 180 190 200
NLTPHGTLFL GHFLKNESSE VKSMMRSFPG SLYYFQLWDH ILENEEFMKC
210 220 230 240 250
LDGNIVSWEE DVWLVNKIIP TVDRTLRCFV PENMTIQEKS TTVSQQIDMT
260 270 280 290 300
TPSQITGVKP QNTAHSSTLL SQSIPIFATD YTTISYSNTT SPPLETMTAQ
310 320 330 340 350
KILKTLVDET ATFAVDVLST SSAISLPTQS ISIDNTTNSM KKTKSPSSES
360 370 380 390 400
TKTTKMVEAM ATEIFQPPTP SNFLSTSRFT KNSVVSTTSA IKSQSAVTKT
410 420 430 440 450
TSLFSTIEST SMSTTPCLKQ KSTNTGALPI STAGQEFIES TAAGTVPWFT
460 470 480 490 500
VEKTSPASTH VGTASSFPPE PVLISTAAPV DSVFPRNQTA FPLATTDMKI
510 520 530 540 550
AFTVHSLTLP TRLIETTPAP RTAETELTST NFQDVSLPRV EDAMSTSMSK
560 570 580 590 600
ETSSKTFSFL TSFSFTGTES VQTVIDAEAT RTALTPEITL ASTVAETMLS
610 620 630 640 650
STITGRVYTQ NTPTADGHLL TLMSTRSAST SKAPESGPTS TTDEAAHLFS
660 670 680 690 700
SNETIWTSRP DQALLASMNT TTILTFVPNE NFTSAFHENT TYTEYLSATT
710 720 730 740 750
NITPLKASPE GKGTTANDAT TARYTTAVSK LTSPWFANFS IVSGTTSITN
760 770 780 790 800
MPEFKLTTLL LKTIPMSTKP ANELPLTPRE TVVPSVDIIS TLACIQPNFS
810 820 830 840 850
TEESASETTQ TEINGAIVFG GTTTPVPKSA TTQRLNATVT RKEATSHYLM
860 870 880 890 900
RKSTIAAVAE VSPFSTMLEV TDESAQRVTA SVTVSSFPDI EKLSTPLDNK
910 920 930 940 950
TATTEVRESW LLTKLVKTTP RSSYNEMTEM FNFNHTYVAH WTSETSEGIS
960 970 980 990 1000
AGSPTSGSTH IFGEPLGAST TRISETSFST TPTDRTATSL SDGILPPQPT
1010 1020 1030 1040 1050
AAHSSATPVP VTHMFSLPVN GSSVVAEETE VTMSEPSTLA RAFSTSVLSD
1060 1070 1080 1090 1100
VSNLSSTTMT TALVPPLDQT ASTTIVIVPT HGDLIRTTSE ATVISVRKTS
1110 1120 1130 1140 1150
MAVPSLTETP FHSLRLSTPV TAKAETTLFS TSVDTVTPST HTLVCSKPPP
1160 1170 1180 1190 1200
DNIPPASSTH VISTTSTPEA TQPISQVEET STYALSFPYT FSGGGVVASL
1210 1220 1230 1240 1250
ATGTTETSVV DETTPSHISA NKLTTSVNSH ISSSATYRVH TPVSIQLVTS
1260 1270 1280 1290 1300
TSVLSSDKDQ MTISLGKTPR TMEVTEMSPS KNSFISYSRG TPSLEMTDTG
1310 1320 1330 1340 1350
FPETTKISSH QTHSPSEIPL GTPSDGNLAS SPTSGSTQIT PTLTSSNTVG
1360 1370 1380 1390 1400
VHIPEMSTSL GKTALPSQAL TITTFLCPEK ESTSALPAYT PRTVEMIVNS
1410 1420 1430 1440 1450
TYVTHSVSYG QDTSFVDTTT SSSTRISNPM DINTTFSHLH SLRTQPEVTS
1460 1470 1480 1490 1500
VASFISESTQ TFPESLSLST AGLYNDGFTV LSDRITTAFS VPNVPTMLPR
1510 1520 1530 1540 1550
ESSMATSTPI YQMSSLPVNV TAFTSKKVSD TPPIVITKSS KTMHPGCLKS
1560 1570 1580 1590 1600
PCTATSGPMS EMSSIPVNNS AFTPATVSSD TSTRVGLFST LLSSVTPRTT
1610 1620 1630 1640 1650
MTMQTSTLDV TPVIYAGATS KNKMVSSAFT TEMIEAPSRI TPTTFLSPTE
1660 1670 1680 1690 1700
PTLPFVKTVP TTIMAGIVTP FVGTTAFSPL SSKSTGAISS IPKTTFSPFL
1710 1720 1730 1740 1750
SATQQSSQAD EATTLGILSG ITNRSLSTVN SGTGVALTDT YSRITVPENM
1760 1770 1780 1790 1800
LSPTHADSLH TSFNIQVSPS LTSFKSASGP TKNVKTTTNC FSSNTRKMTS
1810 1820 1830 1840 1850
LLEKTSLTNY ATSLNTPVSY PPWTPSSATL PSLTSFVYSP HSTEAEISTP
1860 1870 1880 1890 1900
KTSPPPTSQM VEFPVLGTRM TSSNTQPLLM TSWNIPTAEG SQFPISTTIN
1910 1920 1930 1940 1950
VPTSNEMETE TLHLVPGPLS TFTASQTGLV SKDVMAMSSI PMSGILPNHG
1960 1970 1980 1990 2000
LSENPSLSTS LRAITSTLAD VKHTFEKMTT SVTPGTTLPS ILSGATSGSV
2010 2020 2030 2040 2050
ISKSPILTWL LSSLPSGSPP ATVSNAPHVM TSSTVEVSKS TFLTSDMISA
2060 2070 2080 2090 2100
HPFTNLTTLP SATMSTILTR TIPTPTLGGI TTGFPTSLPM SINVTDDIVY
2110 2120 2130 2140 2150
ISTHPEASSR TTITANPRTV SHPSSFSRKT MSPSTTDHTL SVGAMPLPSS
2160 2170 2180 2190 2200
TITSSWNRIP TASSPSTLII PKPTLDSLLN IMTTTSTVPG ASFPLISTGV
2210 2220 2230 2240 2250
TYPFTATVSS PISSFFETTW LDSTPSFLST EASTSPTATK STVSFYNVEM
2260 2270 2280 2290 2300
SFSVFVEEPR IPITSVINEF TENSLNSIFQ NSEFSLATLE TQIKSRDISE
2310 2320 2330 2340 2350
EEMVMDRAIL EQREGQEMAT ISYVPYSCVC QVIIKASSSL ASSELMRKIK
2360 2370 2380 2390 2400
SKIHGNFTHG NFTQDQLTLL VNCEHVAVKK LEPGNCKADE TASKYKGTYK
2410 2420 2430 2440 2450
WLLTNPTETA QTRCIKNEDG NATRFCSISI NTGKSQWEKP KFKQCKLLQE
2460 2470 2480 2490 2500
LPDKIVDLAN ITISDENAED VAEHILNLIN ESPALGKEET KIIVSKISDI
2510 2520 2530 2540 2550
SQCDEISMNL THVMLQIINV VLEKQNNSAS DLHEISNEIL RIIERTGHKM
2560 2570 2580 2590 2600
EFSGQIANLT VAGLALAVLR GDHTFDGMAF SIHSYEEGTD PEIFLGNVPV
2610 2620 2630 2640 2650
GGILASIYLP KSLTERIPLS NLQTILFNFF GQTSLFKTKN VTKALTTYVV
2660 2670 2680 2690 2700
SASISDDMFI QNLADPVVIT LQHIGGNQNY GQVHCAFWDF ENNNGLGGWN
2710 2720 2730 2740 2750
SSGCKVKETN VNYTICQCDH LTHFGVLMDL SRSTVDSVNE QILALITYTG
2760 2770 2780 2790 2800
CGISSIFLGV AVVTYIAFHK LRKDYPAKIL INLCTALLML NLVFLINSWL
2810 2820 2830 2840 2850
SSFQKVGVCI TAAVALHYFL LVSFTWMGLE AVHMYLALVK VFNIYIPNYI
2860 2870 2880 2890 2900
LKFCLVGWGI PAIMVAITVS VKKDLYGTLS PTTPFCWIKD DSIFYISVVA
2910 2920 2930 2940 2950
YFCLIFLMNL SMFCTVLVQL NSVKSQIQKT RRKMILHDLK GTMSLTFLLG
2960 2970 2980 2990 3000
LTWGFAFFAW GPMRNFFLYL FAIFNTLQGF FIFVFHCVMK ESVREQWQIH
3010 3020 3030 3040 3050
LCCGWLRLDN SSDGSSRCQI KVGYKQEGLK KIFEHKLLTP SLKSTATSST
3060 3070 3080
FKSLGSAQGT PSEISFPNDD FDKDPYCSSP
Length:3,080
Mass (Da):333,368
Last modified:September 22, 2009 - v2
Checksum:i3449BC820B251BD3
GO
Isoform 2 (identifier: Q8IZF6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     2243-2381: Missing.
     2593-2637: Missing.
     2979-3012: Missing.
     3069-3080: DDFDKDPYCSSP → APELSALHVVASEPTTG

Show »
Length:2,804
Mass (Da):301,615
Checksum:iB6E45BB089F26D65
GO
Isoform 3 (identifier: Q8IZF6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: D → V
     25-229: Missing.

Note: No experimental confirmation available.

Show »
Length:2,875
Mass (Da):309,429
Checksum:iFC26A9AA34552F93
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2291Missing in AAN46668. (PubMed:12435584)Curated
Sequence conflicti2426 – 24261Missing in AAN46668. (PubMed:12435584)Curated
Sequence conflicti2694 – 26941Missing in AAN46668. (PubMed:12435584)Curated
Sequence conflicti2769 – 27691Missing in AAN46668. (PubMed:12435584)Curated
Sequence conflicti2885 – 28851Missing in AAN46668. (PubMed:12435584)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti276 – 2761I → M.1 Publication
Corresponds to variant rs4829829 [ dbSNP | Ensembl ].
VAR_055929
Natural varianti368 – 3681P → H.1 Publication
Corresponds to variant rs5930931 [ dbSNP | Ensembl ].
VAR_059329
Natural varianti1213 – 12131T → N.
Corresponds to variant rs4829830 [ dbSNP | Ensembl ].
VAR_059330
Natural varianti1540 – 15401S → P.
Corresponds to variant rs912002 [ dbSNP | Ensembl ].
VAR_059331
Natural varianti1791 – 17911F → L.
Corresponds to variant rs5930932 [ dbSNP | Ensembl ].
VAR_059332

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6363Missing in isoform 2. 1 PublicationVSP_038170Add
BLAST
Alternative sequencei24 – 241D → V in isoform 3. CuratedVSP_038171
Alternative sequencei25 – 229205Missing in isoform 3. CuratedVSP_038172Add
BLAST
Alternative sequencei2243 – 2381139Missing in isoform 2. 1 PublicationVSP_038173Add
BLAST
Alternative sequencei2593 – 263745Missing in isoform 2. 1 PublicationVSP_038174Add
BLAST
Alternative sequencei2979 – 301234Missing in isoform 2. 1 PublicationVSP_038175Add
BLAST
Alternative sequencei3069 – 308012DDFDK…YCSSP → APELSALHVVASEPTTG in isoform 2. 1 PublicationVSP_038176Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY140954 mRNA. Translation: AAN46668.1.
AY882585 mRNA. Translation: AAW78659.1.
AL161778, AL078638, AL136167 Genomic DNA. Translation: CAM21249.1.
AL078638, AL136167, AL161778 Genomic DNA. Translation: CAM21580.1.
AL136167, AL078638, AL161778 Genomic DNA. Translation: CAM28221.1.
AL161778, AL078638, AL136167 Genomic DNA. Translation: CAI40998.2.
AL078638, AL136167, AL161778 Genomic DNA. Translation: CAM21579.1.
AL136167, AL078638, AL161778 Genomic DNA. Translation: CAM28220.1.
AY255581 mRNA. Translation: AAO85093.1.
CCDSiCCDS35409.1. [Q8IZF6-1]
RefSeqiNP_722576.3. NM_153834.3. [Q8IZF6-1]
XP_005262424.1. XM_005262367.1. [Q8IZF6-3]
UniGeneiHs.381354.

Genome annotation databases

EnsembliENST00000370652; ENSP00000359686; ENSG00000156920. [Q8IZF6-1]
ENST00000394141; ENSP00000377697; ENSG00000156920. [Q8IZF6-3]
ENST00000394143; ENSP00000377699; ENSG00000156920. [Q8IZF6-1]
GeneIDi139378.
KEGGihsa:139378.
UCSCiuc004ezu.1. human. [Q8IZF6-1]
uc010nsb.1. human. [Q8IZF6-3]
uc010nsc.1. human. [Q8IZF6-2]

Polymorphism databases

DMDMi259016241.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY140954 mRNA. Translation: AAN46668.1 .
AY882585 mRNA. Translation: AAW78659.1 .
AL161778 , AL078638 , AL136167 Genomic DNA. Translation: CAM21249.1 .
AL078638 , AL136167 , AL161778 Genomic DNA. Translation: CAM21580.1 .
AL136167 , AL078638 , AL161778 Genomic DNA. Translation: CAM28221.1 .
AL161778 , AL078638 , AL136167 Genomic DNA. Translation: CAI40998.2 .
AL078638 , AL136167 , AL161778 Genomic DNA. Translation: CAM21579.1 .
AL136167 , AL078638 , AL161778 Genomic DNA. Translation: CAM28220.1 .
AY255581 mRNA. Translation: AAO85093.1 .
CCDSi CCDS35409.1. [Q8IZF6-1 ]
RefSeqi NP_722576.3. NM_153834.3. [Q8IZF6-1 ]
XP_005262424.1. XM_005262367.1. [Q8IZF6-3 ]
UniGenei Hs.381354.

3D structure databases

ProteinModelPortali Q8IZF6.
SMRi Q8IZF6. Positions 2645-2721, 2741-2989.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126563. 1 interaction.

Protein family/group databases

MEROPSi S63.017.
GPCRDBi Search...

PTM databases

PhosphoSitei Q8IZF6.

Polymorphism databases

DMDMi 259016241.

Proteomic databases

MaxQBi Q8IZF6.
PaxDbi Q8IZF6.
PRIDEi Q8IZF6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370652 ; ENSP00000359686 ; ENSG00000156920 . [Q8IZF6-1 ]
ENST00000394141 ; ENSP00000377697 ; ENSG00000156920 . [Q8IZF6-3 ]
ENST00000394143 ; ENSP00000377699 ; ENSG00000156920 . [Q8IZF6-1 ]
GeneIDi 139378.
KEGGi hsa:139378.
UCSCi uc004ezu.1. human. [Q8IZF6-1 ]
uc010nsb.1. human. [Q8IZF6-3 ]
uc010nsc.1. human. [Q8IZF6-2 ]

Organism-specific databases

CTDi 139378.
GeneCardsi GC0XP135383.
HGNCi HGNC:18992. GPR112.
HPAi HPA035324.
neXtProti NX_Q8IZF6.
PharmGKBi PA134885132.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118787.
HOGENOMi HOG000230882.
InParanoidi Q8IZF6.
KOi K08455.
OMAi YFQLWDH.
OrthoDBi EOG7ZGX28.
PhylomeDBi Q8IZF6.
TreeFami TF321769.

Miscellaneous databases

GeneWikii GPR112.
GenomeRNAii 139378.
NextBioi 83952.
PROi Q8IZF6.

Gene expression databases

Bgeei Q8IZF6.
CleanExi HS_GPR112.
Genevestigatori Q8IZF6.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
    Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
    FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Bonner T.I., Kauffman D., Nagle J.W., Sloger M., Kozhich O.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-276 AND HIS-368.
    Tissue: Retina.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-1613 (ISOFORMS 1/2).
  5. "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas."
    Leja J., Essaghir A., Essand M., Wester K., Oeberg K., Toetterman T.H., Lloyd R., Vasmatzis G., Demoulin J.-B., Giandomenico V.
    Mod. Pathol. 22:261-272(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGP112_HUMAN
AccessioniPrimary (citable) accession number: Q8IZF6
Secondary accession number(s): A2A2J1
, A2A2J2, Q5EGP2, Q86SM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3