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Q8IZF6 (GP112_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 112
Gene names
Name:GPR112
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length3080 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma. Ref.5

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IZF6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IZF6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     2243-2381: Missing.
     2593-2637: Missing.
     2979-3012: Missing.
     3069-3080: DDFDKDPYCSSP → APELSALHVVASEPTTG
Isoform 3 (identifier: Q8IZF6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: D → V
     25-229: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 30803053Probable G-protein coupled receptor 112
PRO_0000070335

Regions

Topological domain28 – 27412714Extracellular Potential
Transmembrane2742 – 276221Helical; Name=1; Potential
Topological domain2763 – 277816Cytoplasmic Potential
Transmembrane2779 – 279921Helical; Name=2; Potential
Topological domain2800 – 28056Extracellular Potential
Transmembrane2806 – 282621Helical; Name=3; Potential
Topological domain2827 – 284822Cytoplasmic Potential
Transmembrane2849 – 286921Helical; Name=4; Potential
Topological domain2870 – 289223Extracellular Potential
Transmembrane2893 – 291321Helical; Name=5; Potential
Topological domain2914 – 294229Cytoplasmic Potential
Transmembrane2943 – 296321Helical; Name=6; Potential
Topological domain2964 – 29652Extracellular Potential
Transmembrane2966 – 298621Helical; Name=7; Potential
Topological domain2987 – 308094Cytoplasmic Potential
Domain2682 – 273352GPS

Amino acid modifications

Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation4871N-linked (GlcNAc...) Potential
Glycosylation8361N-linked (GlcNAc...) Potential
Glycosylation8991N-linked (GlcNAc...) Potential
Glycosylation10201N-linked (GlcNAc...) Potential
Glycosylation15191N-linked (GlcNAc...) Potential
Glycosylation23611N-linked (GlcNAc...) Potential
Glycosylation26401N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 6363Missing in isoform 2.
VSP_038170
Alternative sequence241D → V in isoform 3.
VSP_038171
Alternative sequence25 – 229205Missing in isoform 3.
VSP_038172
Alternative sequence2243 – 2381139Missing in isoform 2.
VSP_038173
Alternative sequence2593 – 263745Missing in isoform 2.
VSP_038174
Alternative sequence2979 – 301234Missing in isoform 2.
VSP_038175
Alternative sequence3069 – 308012DDFDK…YCSSP → APELSALHVVASEPTTG in isoform 2.
VSP_038176
Natural variant2761I → M. Ref.2
Corresponds to variant rs4829829 [ dbSNP | Ensembl ].
VAR_055929
Natural variant3681P → H. Ref.2
Corresponds to variant rs5930931 [ dbSNP | Ensembl ].
VAR_059329
Natural variant12131T → N.
Corresponds to variant rs4829830 [ dbSNP | Ensembl ].
VAR_059330
Natural variant15401S → P.
Corresponds to variant rs912002 [ dbSNP | Ensembl ].
VAR_059331
Natural variant17911F → L.
Corresponds to variant rs5930932 [ dbSNP | Ensembl ].
VAR_059332

Experimental info

Sequence conflict2291Missing in AAN46668. Ref.1
Sequence conflict24261Missing in AAN46668. Ref.1
Sequence conflict26941Missing in AAN46668. Ref.1
Sequence conflict27691Missing in AAN46668. Ref.1
Sequence conflict28851Missing in AAN46668. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 3449BC820B251BD3

FASTA3,080333,368
        10         20         30         40         50         60 
MKEHIIYQKL YGLILMSSFI FLSDTLSLKG KKLDFFGRGD TYVSLIDTIP ELSRFTACID 

        70         80         90        100        110        120 
LVFMDDNSRY WMAFSYITNN ALLGREDIDL GLAGDHQQLI LYRLGKTFSI RHHLASFQWH 

       130        140        150        160        170        180 
TICLIWDGVK GKLELFLNKE RILEVTDQPH NLTPHGTLFL GHFLKNESSE VKSMMRSFPG 

       190        200        210        220        230        240 
SLYYFQLWDH ILENEEFMKC LDGNIVSWEE DVWLVNKIIP TVDRTLRCFV PENMTIQEKS 

       250        260        270        280        290        300 
TTVSQQIDMT TPSQITGVKP QNTAHSSTLL SQSIPIFATD YTTISYSNTT SPPLETMTAQ 

       310        320        330        340        350        360 
KILKTLVDET ATFAVDVLST SSAISLPTQS ISIDNTTNSM KKTKSPSSES TKTTKMVEAM 

       370        380        390        400        410        420 
ATEIFQPPTP SNFLSTSRFT KNSVVSTTSA IKSQSAVTKT TSLFSTIEST SMSTTPCLKQ 

       430        440        450        460        470        480 
KSTNTGALPI STAGQEFIES TAAGTVPWFT VEKTSPASTH VGTASSFPPE PVLISTAAPV 

       490        500        510        520        530        540 
DSVFPRNQTA FPLATTDMKI AFTVHSLTLP TRLIETTPAP RTAETELTST NFQDVSLPRV 

       550        560        570        580        590        600 
EDAMSTSMSK ETSSKTFSFL TSFSFTGTES VQTVIDAEAT RTALTPEITL ASTVAETMLS 

       610        620        630        640        650        660 
STITGRVYTQ NTPTADGHLL TLMSTRSAST SKAPESGPTS TTDEAAHLFS SNETIWTSRP 

       670        680        690        700        710        720 
DQALLASMNT TTILTFVPNE NFTSAFHENT TYTEYLSATT NITPLKASPE GKGTTANDAT 

       730        740        750        760        770        780 
TARYTTAVSK LTSPWFANFS IVSGTTSITN MPEFKLTTLL LKTIPMSTKP ANELPLTPRE 

       790        800        810        820        830        840 
TVVPSVDIIS TLACIQPNFS TEESASETTQ TEINGAIVFG GTTTPVPKSA TTQRLNATVT 

       850        860        870        880        890        900 
RKEATSHYLM RKSTIAAVAE VSPFSTMLEV TDESAQRVTA SVTVSSFPDI EKLSTPLDNK 

       910        920        930        940        950        960 
TATTEVRESW LLTKLVKTTP RSSYNEMTEM FNFNHTYVAH WTSETSEGIS AGSPTSGSTH 

       970        980        990       1000       1010       1020 
IFGEPLGAST TRISETSFST TPTDRTATSL SDGILPPQPT AAHSSATPVP VTHMFSLPVN 

      1030       1040       1050       1060       1070       1080 
GSSVVAEETE VTMSEPSTLA RAFSTSVLSD VSNLSSTTMT TALVPPLDQT ASTTIVIVPT 

      1090       1100       1110       1120       1130       1140 
HGDLIRTTSE ATVISVRKTS MAVPSLTETP FHSLRLSTPV TAKAETTLFS TSVDTVTPST 

      1150       1160       1170       1180       1190       1200 
HTLVCSKPPP DNIPPASSTH VISTTSTPEA TQPISQVEET STYALSFPYT FSGGGVVASL 

      1210       1220       1230       1240       1250       1260 
ATGTTETSVV DETTPSHISA NKLTTSVNSH ISSSATYRVH TPVSIQLVTS TSVLSSDKDQ 

      1270       1280       1290       1300       1310       1320 
MTISLGKTPR TMEVTEMSPS KNSFISYSRG TPSLEMTDTG FPETTKISSH QTHSPSEIPL 

      1330       1340       1350       1360       1370       1380 
GTPSDGNLAS SPTSGSTQIT PTLTSSNTVG VHIPEMSTSL GKTALPSQAL TITTFLCPEK 

      1390       1400       1410       1420       1430       1440 
ESTSALPAYT PRTVEMIVNS TYVTHSVSYG QDTSFVDTTT SSSTRISNPM DINTTFSHLH 

      1450       1460       1470       1480       1490       1500 
SLRTQPEVTS VASFISESTQ TFPESLSLST AGLYNDGFTV LSDRITTAFS VPNVPTMLPR 

      1510       1520       1530       1540       1550       1560 
ESSMATSTPI YQMSSLPVNV TAFTSKKVSD TPPIVITKSS KTMHPGCLKS PCTATSGPMS 

      1570       1580       1590       1600       1610       1620 
EMSSIPVNNS AFTPATVSSD TSTRVGLFST LLSSVTPRTT MTMQTSTLDV TPVIYAGATS 

      1630       1640       1650       1660       1670       1680 
KNKMVSSAFT TEMIEAPSRI TPTTFLSPTE PTLPFVKTVP TTIMAGIVTP FVGTTAFSPL 

      1690       1700       1710       1720       1730       1740 
SSKSTGAISS IPKTTFSPFL SATQQSSQAD EATTLGILSG ITNRSLSTVN SGTGVALTDT 

      1750       1760       1770       1780       1790       1800 
YSRITVPENM LSPTHADSLH TSFNIQVSPS LTSFKSASGP TKNVKTTTNC FSSNTRKMTS 

      1810       1820       1830       1840       1850       1860 
LLEKTSLTNY ATSLNTPVSY PPWTPSSATL PSLTSFVYSP HSTEAEISTP KTSPPPTSQM 

      1870       1880       1890       1900       1910       1920 
VEFPVLGTRM TSSNTQPLLM TSWNIPTAEG SQFPISTTIN VPTSNEMETE TLHLVPGPLS 

      1930       1940       1950       1960       1970       1980 
TFTASQTGLV SKDVMAMSSI PMSGILPNHG LSENPSLSTS LRAITSTLAD VKHTFEKMTT 

      1990       2000       2010       2020       2030       2040 
SVTPGTTLPS ILSGATSGSV ISKSPILTWL LSSLPSGSPP ATVSNAPHVM TSSTVEVSKS 

      2050       2060       2070       2080       2090       2100 
TFLTSDMISA HPFTNLTTLP SATMSTILTR TIPTPTLGGI TTGFPTSLPM SINVTDDIVY 

      2110       2120       2130       2140       2150       2160 
ISTHPEASSR TTITANPRTV SHPSSFSRKT MSPSTTDHTL SVGAMPLPSS TITSSWNRIP 

      2170       2180       2190       2200       2210       2220 
TASSPSTLII PKPTLDSLLN IMTTTSTVPG ASFPLISTGV TYPFTATVSS PISSFFETTW 

      2230       2240       2250       2260       2270       2280 
LDSTPSFLST EASTSPTATK STVSFYNVEM SFSVFVEEPR IPITSVINEF TENSLNSIFQ 

      2290       2300       2310       2320       2330       2340 
NSEFSLATLE TQIKSRDISE EEMVMDRAIL EQREGQEMAT ISYVPYSCVC QVIIKASSSL 

      2350       2360       2370       2380       2390       2400 
ASSELMRKIK SKIHGNFTHG NFTQDQLTLL VNCEHVAVKK LEPGNCKADE TASKYKGTYK 

      2410       2420       2430       2440       2450       2460 
WLLTNPTETA QTRCIKNEDG NATRFCSISI NTGKSQWEKP KFKQCKLLQE LPDKIVDLAN 

      2470       2480       2490       2500       2510       2520 
ITISDENAED VAEHILNLIN ESPALGKEET KIIVSKISDI SQCDEISMNL THVMLQIINV 

      2530       2540       2550       2560       2570       2580 
VLEKQNNSAS DLHEISNEIL RIIERTGHKM EFSGQIANLT VAGLALAVLR GDHTFDGMAF 

      2590       2600       2610       2620       2630       2640 
SIHSYEEGTD PEIFLGNVPV GGILASIYLP KSLTERIPLS NLQTILFNFF GQTSLFKTKN 

      2650       2660       2670       2680       2690       2700 
VTKALTTYVV SASISDDMFI QNLADPVVIT LQHIGGNQNY GQVHCAFWDF ENNNGLGGWN 

      2710       2720       2730       2740       2750       2760 
SSGCKVKETN VNYTICQCDH LTHFGVLMDL SRSTVDSVNE QILALITYTG CGISSIFLGV 

      2770       2780       2790       2800       2810       2820 
AVVTYIAFHK LRKDYPAKIL INLCTALLML NLVFLINSWL SSFQKVGVCI TAAVALHYFL 

      2830       2840       2850       2860       2870       2880 
LVSFTWMGLE AVHMYLALVK VFNIYIPNYI LKFCLVGWGI PAIMVAITVS VKKDLYGTLS 

      2890       2900       2910       2920       2930       2940 
PTTPFCWIKD DSIFYISVVA YFCLIFLMNL SMFCTVLVQL NSVKSQIQKT RRKMILHDLK 

      2950       2960       2970       2980       2990       3000 
GTMSLTFLLG LTWGFAFFAW GPMRNFFLYL FAIFNTLQGF FIFVFHCVMK ESVREQWQIH 

      3010       3020       3030       3040       3050       3060 
LCCGWLRLDN SSDGSSRCQI KVGYKQEGLK KIFEHKLLTP SLKSTATSST FKSLGSAQGT 

      3070       3080 
PSEISFPNDD FDKDPYCSSP 

« Hide

Isoform 2 [UniParc].

Checksum: B6E45BB089F26D65
Show »

FASTA2,804301,615
Isoform 3 [UniParc].

Checksum: FC26A9AA34552F93
Show »

FASTA2,875309,429

References

« Hide 'large scale' references
[1]"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]Bonner T.I., Kauffman D., Nagle J.W., Sloger M., Kozhich O.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MET-276 AND HIS-368.
Tissue: Retina.
[3]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-1613 (ISOFORMS 1/2).
[5]"Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas."
Leja J., Essaghir A., Essand M., Wester K., Oeberg K., Toetterman T.H., Lloyd R., Vasmatzis G., Demoulin J.-B., Giandomenico V.
Mod. Pathol. 22:261-272(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY140954 mRNA. Translation: AAN46668.1.
AY882585 mRNA. Translation: AAW78659.1.
AL161778, AL078638, AL136167 Genomic DNA. Translation: CAM21249.1.
AL078638, AL136167, AL161778 Genomic DNA. Translation: CAM21580.1.
AL136167, AL078638, AL161778 Genomic DNA. Translation: CAM28221.1.
AL161778, AL078638, AL136167 Genomic DNA. Translation: CAI40998.2.
AL078638, AL136167, AL161778 Genomic DNA. Translation: CAM21579.1.
AL136167, AL078638, AL161778 Genomic DNA. Translation: CAM28220.1.
AY255581 mRNA. Translation: AAO85093.1.
RefSeqNP_722576.3. NM_153834.3.
XP_005262424.1. XM_005262367.1.
UniGeneHs.381354.

3D structure databases

ProteinModelPortalQ8IZF6.
SMRQ8IZF6. Positions 2645-2721, 2741-2989.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS63.017.
GPCRDBSearch...

PTM databases

PhosphoSiteQ8IZF6.

Polymorphism databases

DMDM259016241.

Proteomic databases

PaxDbQ8IZF6.
PRIDEQ8IZF6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000287534; ENSP00000287534; ENSG00000156920. [Q8IZF6-2]
ENST00000370652; ENSP00000359686; ENSG00000156920. [Q8IZF6-1]
ENST00000394141; ENSP00000377697; ENSG00000156920. [Q8IZF6-3]
ENST00000394143; ENSP00000377699; ENSG00000156920. [Q8IZF6-1]
ENST00000412101; ENSP00000416526; ENSG00000156920. [Q8IZF6-3]
GeneID139378.
KEGGhsa:139378.
UCSCuc004ezu.1. human. [Q8IZF6-1]
uc010nsb.1. human. [Q8IZF6-3]
uc010nsc.1. human. [Q8IZF6-2]

Organism-specific databases

CTD139378.
GeneCardsGC0XP135383.
HGNCHGNC:18992. GPR112.
HPAHPA035324.
neXtProtNX_Q8IZF6.
PharmGKBPA134885132.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000230882.
KOK08455.
OMAYFQLWDH.
OrthoDBEOG7ZGX28.
PhylomeDBQ8IZF6.
TreeFamTF321769.

Gene expression databases

BgeeQ8IZF6.
CleanExHS_GPR112.
GenevestigatorQ8IZF6.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
SMARTSM00303. GPS. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR112.
GenomeRNAi139378.
NextBio83952.
PROQ8IZF6.

Entry information

Entry nameGP112_HUMAN
AccessionPrimary (citable) accession number: Q8IZF6
Secondary accession number(s): A2A2J1 expand/collapse secondary AC list , A2A2J2, Q5EGP2, Q86SM6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: September 22, 2009
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries