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Q8IZF4 (GP114_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 114
Alternative name(s):
G-protein coupled receptor PGR27
Gene names
Name:GPR114
Synonyms:PGR27
ORF Names:UNQ2524/PRO6017
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Sequence caution

The sequence AAN46670.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAD18748.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 528507Probable G-protein coupled receptor 114
PRO_0000012894

Regions

Topological domain22 – 250229Extracellular Potential
Transmembrane251 – 27121Helical; Name=1; Potential
Topological domain272 – 29019Cytoplasmic Potential
Transmembrane291 – 31121Helical; Name=2; Potential
Topological domain312 – 32312Extracellular Potential
Transmembrane324 – 34421Helical; Name=3; Potential
Topological domain345 – 3539Cytoplasmic Potential
Transmembrane354 – 37421Helical; Name=4; Potential
Topological domain375 – 41339Extracellular Potential
Transmembrane414 – 43421Helical; Name=5; Potential
Topological domain435 – 45622Cytoplasmic Potential
Transmembrane457 – 47923Helical; Name=6; Potential
Topological domain480 – 4823Extracellular Potential
Transmembrane483 – 50523Helical; Name=7; Potential
Topological domain506 – 52823Cytoplasmic Potential
Domain186 – 23853GPS

Amino acid modifications

Glycosylation181N-linked (GlcNAc...) Potential
Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation1461N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential
Glycosylation4001N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict177 – 1826WHNQSL → PSISTQ in BAD18711. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8IZF4 [UniParc].

Last modified May 29, 2007. Version 3.
Checksum: 35DE5E5C34FD2A3C

FASTA52859,000
        10         20         30         40         50         60 
MDHCGALFLC LCLLTLQNAT TETWEELLSY MENMQVSRGR SSVFSSRQLH QLEQMLLNTS 

        70         80         90        100        110        120 
FPGYNLTLQT PTIQSLAFKL SCDFSGLSLT SATLKRVPQA GGQHARGQHA MQFPAELTRD 

       130        140        150        160        170        180 
ACKTRPRELR LICIYFSNTH FFKDENNSSL LNNYVLGAQL SHGHVNNLRD PVNISFWHNQ 

       190        200        210        220        230        240 
SLEGYTLTCV FWKEGARKQP WGGWSPEGCR TEQPSHSQVL CRCNHLTYFA VLMQLSPALV 

       250        260        270        280        290        300 
PAELLAPLTY ISLVGCSISI VASLITVLLH FHFRKQSDSL TRIHMNLHAS VLLLNIAFLL 

       310        320        330        340        350        360 
SPAFAMSPVP GSACTALAAA LHYALLSCLT WMAIEGFNLY LLLGRVYNIY IRRYVFKLGV 

       370        380        390        400        410        420 
LGWGAPALLV LLSLSVKSSV YGPCTIPVFD SWENGTGFQN MSICWVRSPV VHSVLVMGYG 

       430        440        450        460        470        480 
GLTSLFNLVV LAWALWTLRR LRERADAPSV RACHDTVTVL GLTVLLGTTW ALAFFSFGVF 

       490        500        510        520 
LLPQLFLFTI LNSLYGFFLF LWFCSQRCRS EAEAKAQIEA FSSSQTTQ 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon, Spleen and Thymus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[5]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-225.
[6]"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358447 mRNA. Translation: AAQ88812.1.
AK128298 mRNA. Translation: BAG54657.1.
AK172765 mRNA. Translation: BAD18748.1. Different initiation.
AK160368 mRNA. Translation: BAD18711.1.
CH471092 Genomic DNA. Translation: EAW82936.1.
BC032401 mRNA. Translation: AAH32401.1.
AY255609 mRNA. Translation: AAO85121.1.
AY140956 mRNA. Translation: AAN46670.1. Sequence problems.
CCDSCCDS10785.1.
RefSeqNP_722579.1. NM_153837.1.
XP_005255893.1. XM_005255836.1.
XP_006721232.1. XM_006721169.1.
UniGeneHs.187884.

3D structure databases

ProteinModelPortalQ8IZF4.
SMRQ8IZF4. Positions 283-504.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128696. 1 interaction.
IntActQ8IZF4. 1 interaction.

Protein family/group databases

MEROPSS63.019.
GPCRDBSearch...

PTM databases

PhosphoSiteQ8IZF4.

Polymorphism databases

DMDM148886621.

Proteomic databases

PaxDbQ8IZF4.
PRIDEQ8IZF4.

Protocols and materials databases

DNASU221188.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340339; ENSP00000342981; ENSG00000159618.
ENST00000349457; ENSP00000290823; ENSG00000159618.
GeneID221188.
KEGGhsa:221188.
UCSCuc002elx.4. human.

Organism-specific databases

CTD221188.
GeneCardsGC16P057576.
HGNCHGNC:19010. GPR114.
HPAHPA007133.
neXtProtNX_Q8IZF4.
PharmGKBPA134896363.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG244753.
HOGENOMHOG000015136.
HOVERGENHBG107961.
KOK08459.
OMAFLFLWFC.
OrthoDBEOG776SPS.
PhylomeDBQ8IZF4.
TreeFamTF321769.

Gene expression databases

BgeeQ8IZF4.
CleanExHS_GPR114.
GenevestigatorQ8IZF4.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR003910. GPCR_2_orphan_rcpt_GPR56.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTSM00303. GPS. 1 hit.
[Graphical view]
PROSITEPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR114.
GenomeRNAi221188.
NextBio91231.
PROQ8IZF4.

Entry information

Entry nameGP114_HUMAN
AccessionPrimary (citable) accession number: Q8IZF4
Secondary accession number(s): B3KXZ5 expand/collapse secondary AC list , Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 29, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries