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Protein

Probable G-protein coupled receptor 114

Gene

GPR114

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 114
Alternative name(s):
G-protein coupled receptor PGR27
Gene namesi
Name:GPR114
Synonyms:PGR27
ORF Names:UNQ2524/PRO6017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19010. GPR114.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 250229ExtracellularSequence AnalysisAdd
BLAST
Transmembranei251 – 27121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini272 – 29019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei291 – 31121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini312 – 32312ExtracellularSequence AnalysisAdd
BLAST
Transmembranei324 – 34421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini345 – 3539CytoplasmicSequence Analysis
Transmembranei354 – 37421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini375 – 41339ExtracellularSequence AnalysisAdd
BLAST
Transmembranei414 – 43421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini435 – 45622CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei457 – 47923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini480 – 4823ExtracellularSequence Analysis
Transmembranei483 – 50523Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini506 – 52823CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896363.

Polymorphism and mutation databases

BioMutaiGPR114.
DMDMi148886621.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 528507Probable G-protein coupled receptor 114PRO_0000012894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZF4.
PRIDEiQ8IZF4.

PTM databases

PhosphoSiteiQ8IZF4.

Expressioni

Gene expression databases

BgeeiQ8IZF4.
CleanExiHS_GPR114.
ExpressionAtlasiQ8IZF4. baseline and differential.
GenevestigatoriQ8IZF4.

Organism-specific databases

HPAiHPA007133.

Interactioni

Protein-protein interaction databases

BioGridi128696. 97 interactions.
IntActiQ8IZF4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8IZF4.
SMRiQ8IZF4. Positions 283-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 23853GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG244753.
GeneTreeiENSGT00760000118787.
HOGENOMiHOG000015136.
HOVERGENiHBG107961.
InParanoidiQ8IZF4.
KOiK08459.
OMAiPVNISFW.
OrthoDBiEOG776SPS.
PhylomeDBiQ8IZF4.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR003910. GPCR_2_orphan_rcpt_GPR56.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHCGALFLC LCLLTLQNAT TETWEELLSY MENMQVSRGR SSVFSSRQLH
60 70 80 90 100
QLEQMLLNTS FPGYNLTLQT PTIQSLAFKL SCDFSGLSLT SATLKRVPQA
110 120 130 140 150
GGQHARGQHA MQFPAELTRD ACKTRPRELR LICIYFSNTH FFKDENNSSL
160 170 180 190 200
LNNYVLGAQL SHGHVNNLRD PVNISFWHNQ SLEGYTLTCV FWKEGARKQP
210 220 230 240 250
WGGWSPEGCR TEQPSHSQVL CRCNHLTYFA VLMQLSPALV PAELLAPLTY
260 270 280 290 300
ISLVGCSISI VASLITVLLH FHFRKQSDSL TRIHMNLHAS VLLLNIAFLL
310 320 330 340 350
SPAFAMSPVP GSACTALAAA LHYALLSCLT WMAIEGFNLY LLLGRVYNIY
360 370 380 390 400
IRRYVFKLGV LGWGAPALLV LLSLSVKSSV YGPCTIPVFD SWENGTGFQN
410 420 430 440 450
MSICWVRSPV VHSVLVMGYG GLTSLFNLVV LAWALWTLRR LRERADAPSV
460 470 480 490 500
RACHDTVTVL GLTVLLGTTW ALAFFSFGVF LLPQLFLFTI LNSLYGFFLF
510 520
LWFCSQRCRS EAEAKAQIEA FSSSQTTQ
Length:528
Mass (Da):59,000
Last modified:May 29, 2007 - v3
Checksum:i35DE5E5C34FD2A3C
GO

Sequence cautioni

The sequence AAN46670.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAD18748.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1826WHNQSL → PSISTQ in BAD18711 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358447 mRNA. Translation: AAQ88812.1.
AK128298 mRNA. Translation: BAG54657.1.
AK172765 mRNA. Translation: BAD18748.1. Different initiation.
AK160368 mRNA. Translation: BAD18711.1.
CH471092 Genomic DNA. Translation: EAW82936.1.
BC032401 mRNA. Translation: AAH32401.1.
AY255609 mRNA. Translation: AAO85121.1.
AY140956 mRNA. Translation: AAN46670.1. Sequence problems.
CCDSiCCDS10785.1.
RefSeqiNP_722579.1. NM_153837.2.
XP_006721232.1. XM_006721169.2.
UniGeneiHs.187884.

Genome annotation databases

EnsembliENST00000340339; ENSP00000342981; ENSG00000159618.
ENST00000349457; ENSP00000290823; ENSG00000159618.
GeneIDi221188.
KEGGihsa:221188.
UCSCiuc002elx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358447 mRNA. Translation: AAQ88812.1.
AK128298 mRNA. Translation: BAG54657.1.
AK172765 mRNA. Translation: BAD18748.1. Different initiation.
AK160368 mRNA. Translation: BAD18711.1.
CH471092 Genomic DNA. Translation: EAW82936.1.
BC032401 mRNA. Translation: AAH32401.1.
AY255609 mRNA. Translation: AAO85121.1.
AY140956 mRNA. Translation: AAN46670.1. Sequence problems.
CCDSiCCDS10785.1.
RefSeqiNP_722579.1. NM_153837.2.
XP_006721232.1. XM_006721169.2.
UniGeneiHs.187884.

3D structure databases

ProteinModelPortaliQ8IZF4.
SMRiQ8IZF4. Positions 283-504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128696. 97 interactions.
IntActiQ8IZF4. 1 interaction.

Protein family/group databases

MEROPSiS63.019.
GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8IZF4.

Polymorphism and mutation databases

BioMutaiGPR114.
DMDMi148886621.

Proteomic databases

PaxDbiQ8IZF4.
PRIDEiQ8IZF4.

Protocols and materials databases

DNASUi221188.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340339; ENSP00000342981; ENSG00000159618.
ENST00000349457; ENSP00000290823; ENSG00000159618.
GeneIDi221188.
KEGGihsa:221188.
UCSCiuc002elx.4. human.

Organism-specific databases

CTDi221188.
GeneCardsiGC16P057576.
HGNCiHGNC:19010. GPR114.
HPAiHPA007133.
neXtProtiNX_Q8IZF4.
PharmGKBiPA134896363.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG244753.
GeneTreeiENSGT00760000118787.
HOGENOMiHOG000015136.
HOVERGENiHBG107961.
InParanoidiQ8IZF4.
KOiK08459.
OMAiPVNISFW.
OrthoDBiEOG776SPS.
PhylomeDBiQ8IZF4.
TreeFamiTF321769.

Miscellaneous databases

GeneWikiiGPR114.
GenomeRNAii221188.
NextBioi91231.
PROiQ8IZF4.

Gene expression databases

BgeeiQ8IZF4.
CleanExiHS_GPR114.
ExpressionAtlasiQ8IZF4. baseline and differential.
GenevestigatoriQ8IZF4.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR003910. GPCR_2_orphan_rcpt_GPR56.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Spleen and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-225.
  6. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
    Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
    FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiGP114_HUMAN
AccessioniPrimary (citable) accession number: Q8IZF4
Secondary accession number(s): B3KXZ5
, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 29, 2007
Last modified: May 27, 2015
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.