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Protein

Adhesion G-protein coupled receptor G5

Gene

ADGRG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).By similarity1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G5
Alternative name(s):
G-protein coupled receptor 114
G-protein coupled receptor PGR27
Gene namesi
Name:ADGRG5
Synonyms:GPR114, PGR27
ORF Names:UNQ2524/PRO6017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19010. ADGRG5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 250ExtracellularCuratedAdd BLAST229
Transmembranei251 – 271Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini272 – 290CytoplasmicCuratedAdd BLAST19
Transmembranei291 – 311Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini312 – 323ExtracellularCuratedAdd BLAST12
Transmembranei324 – 344Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini345 – 353CytoplasmicCurated9
Transmembranei354 – 374Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini375 – 413ExtracellularCuratedAdd BLAST39
Transmembranei414 – 434Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini435 – 456CytoplasmicCuratedAdd BLAST22
Transmembranei457 – 479Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini480 – 482ExtracellularCurated3
Transmembranei483 – 505Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini506 – 528CytoplasmicCuratedAdd BLAST23

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi221188.
OpenTargetsiENSG00000159618.
PharmGKBiPA134896363.

Polymorphism and mutation databases

BioMutaiGPR114.
DMDMi148886621.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001289422 – 528Adhesion G-protein coupled receptor G5Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1
Glycosylationi400N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Autoproteolysis between residues Leu-226 and Thr-227 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N-terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei226 – 227Cleavage; by autolysis1 Publication2

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZF4.
PeptideAtlasiQ8IZF4.
PRIDEiQ8IZF4.

PTM databases

iPTMnetiQ8IZF4.
PhosphoSitePlusiQ8IZF4.

Expressioni

Tissue specificityi

Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils.1 Publication

Gene expression databases

BgeeiENSG00000159618.
CleanExiHS_GPR114.
ExpressionAtlasiQ8IZF4. baseline and differential.
GenevisibleiQ8IZF4. HS.

Organism-specific databases

HPAiHPA007133.

Interactioni

Protein-protein interaction databases

BioGridi128696. 80 interactors.
IntActiQ8IZF4. 1 interactor.
STRINGi9606.ENSP00000290823.

Structurei

3D structure databases

ProteinModelPortaliQ8IZF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 238GPSPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000015136.
HOVERGENiHBG107961.
InParanoidiQ8IZF4.
KOiK08459.
OMAiFLWFCSQ.
OrthoDBiEOG091G090X.
PhylomeDBiQ8IZF4.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR003910. GPR1/GPR3/GPR5.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHCGALFLC LCLLTLQNAT TETWEELLSY MENMQVSRGR SSVFSSRQLH
60 70 80 90 100
QLEQMLLNTS FPGYNLTLQT PTIQSLAFKL SCDFSGLSLT SATLKRVPQA
110 120 130 140 150
GGQHARGQHA MQFPAELTRD ACKTRPRELR LICIYFSNTH FFKDENNSSL
160 170 180 190 200
LNNYVLGAQL SHGHVNNLRD PVNISFWHNQ SLEGYTLTCV FWKEGARKQP
210 220 230 240 250
WGGWSPEGCR TEQPSHSQVL CRCNHLTYFA VLMQLSPALV PAELLAPLTY
260 270 280 290 300
ISLVGCSISI VASLITVLLH FHFRKQSDSL TRIHMNLHAS VLLLNIAFLL
310 320 330 340 350
SPAFAMSPVP GSACTALAAA LHYALLSCLT WMAIEGFNLY LLLGRVYNIY
360 370 380 390 400
IRRYVFKLGV LGWGAPALLV LLSLSVKSSV YGPCTIPVFD SWENGTGFQN
410 420 430 440 450
MSICWVRSPV VHSVLVMGYG GLTSLFNLVV LAWALWTLRR LRERADAPSV
460 470 480 490 500
RACHDTVTVL GLTVLLGTTW ALAFFSFGVF LLPQLFLFTI LNSLYGFFLF
510 520
LWFCSQRCRS EAEAKAQIEA FSSSQTTQ
Length:528
Mass (Da):59,000
Last modified:May 29, 2007 - v3
Checksum:i35DE5E5C34FD2A3C
GO

Sequence cautioni

The sequence AAN46670 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD18748 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177 – 182WHNQSL → PSISTQ in BAD18711 (PubMed:14702039).Curated6
Sequence conflicti229F → S in BAF85472 (PubMed:14702039).Curated1
Sequence conflicti251I → T in BAF85472 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358447 mRNA. Translation: AAQ88812.1.
AK128298 mRNA. Translation: BAG54657.1.
AK160368 mRNA. Translation: BAD18711.1.
AK172765 mRNA. Translation: BAD18748.1. Different initiation.
AK292783 mRNA. Translation: BAF85472.1.
CH471092 Genomic DNA. Translation: EAW82936.1.
CH471092 Genomic DNA. Translation: EAW82938.1.
BC032401 mRNA. Translation: AAH32401.1.
AY255609 mRNA. Translation: AAO85121.1.
AY140956 mRNA. Translation: AAN46670.1. Sequence problems.
CCDSiCCDS10785.1.
RefSeqiNP_001291305.1. NM_001304376.2.
NP_001305410.1. NM_001318481.1.
NP_722579.1. NM_153837.3.
XP_011521251.1. XM_011522949.2.
XP_011521252.1. XM_011522950.2.
UniGeneiHs.187884.

Genome annotation databases

EnsembliENST00000340339; ENSP00000342981; ENSG00000159618.
ENST00000349457; ENSP00000290823; ENSG00000159618.
GeneIDi221188.
KEGGihsa:221188.
UCSCiuc002elx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358447 mRNA. Translation: AAQ88812.1.
AK128298 mRNA. Translation: BAG54657.1.
AK160368 mRNA. Translation: BAD18711.1.
AK172765 mRNA. Translation: BAD18748.1. Different initiation.
AK292783 mRNA. Translation: BAF85472.1.
CH471092 Genomic DNA. Translation: EAW82936.1.
CH471092 Genomic DNA. Translation: EAW82938.1.
BC032401 mRNA. Translation: AAH32401.1.
AY255609 mRNA. Translation: AAO85121.1.
AY140956 mRNA. Translation: AAN46670.1. Sequence problems.
CCDSiCCDS10785.1.
RefSeqiNP_001291305.1. NM_001304376.2.
NP_001305410.1. NM_001318481.1.
NP_722579.1. NM_153837.3.
XP_011521251.1. XM_011522949.2.
XP_011521252.1. XM_011522950.2.
UniGeneiHs.187884.

3D structure databases

ProteinModelPortaliQ8IZF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128696. 80 interactors.
IntActiQ8IZF4. 1 interactor.
STRINGi9606.ENSP00000290823.

Protein family/group databases

MEROPSiP02.016.
GPCRDBiSearch...

PTM databases

iPTMnetiQ8IZF4.
PhosphoSitePlusiQ8IZF4.

Polymorphism and mutation databases

BioMutaiGPR114.
DMDMi148886621.

Proteomic databases

PaxDbiQ8IZF4.
PeptideAtlasiQ8IZF4.
PRIDEiQ8IZF4.

Protocols and materials databases

DNASUi221188.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340339; ENSP00000342981; ENSG00000159618.
ENST00000349457; ENSP00000290823; ENSG00000159618.
GeneIDi221188.
KEGGihsa:221188.
UCSCiuc002elx.5. human.

Organism-specific databases

CTDi221188.
DisGeNETi221188.
GeneCardsiADGRG5.
HGNCiHGNC:19010. ADGRG5.
HPAiHPA007133.
MIMi616965. gene.
neXtProtiNX_Q8IZF4.
OpenTargetsiENSG00000159618.
PharmGKBiPA134896363.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000015136.
HOVERGENiHBG107961.
InParanoidiQ8IZF4.
KOiK08459.
OMAiFLWFCSQ.
OrthoDBiEOG091G090X.
PhylomeDBiQ8IZF4.
TreeFamiTF321769.

Miscellaneous databases

GeneWikiiGPR114.
GenomeRNAii221188.
PROiQ8IZF4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159618.
CleanExiHS_GPR114.
ExpressionAtlasiQ8IZF4. baseline and differential.
GenevisibleiQ8IZF4. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR003910. GPR1/GPR3/GPR5.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG5_HUMAN
AccessioniPrimary (citable) accession number: Q8IZF4
Secondary accession number(s): A0A024R6S3
, A8K9R8, B3KXZ5, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.