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Q8IZF4

- GP114_HUMAN

UniProt

Q8IZF4 - GP114_HUMAN

Protein

Probable G-protein coupled receptor 114

Gene

GPR114

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (29 May 2007)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Protein family/group databases

    MEROPSiS63.019.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 114
    Alternative name(s):
    G-protein coupled receptor PGR27
    Gene namesi
    Name:GPR114
    Synonyms:PGR27
    ORF Names:UNQ2524/PRO6017
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:19010. GPR114.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134896363.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 528507Probable G-protein coupled receptor 114PRO_0000012894Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8IZF4.
    PRIDEiQ8IZF4.

    PTM databases

    PhosphoSiteiQ8IZF4.

    Expressioni

    Gene expression databases

    BgeeiQ8IZF4.
    CleanExiHS_GPR114.
    GenevestigatoriQ8IZF4.

    Organism-specific databases

    HPAiHPA007133.

    Interactioni

    Protein-protein interaction databases

    BioGridi128696. 1 interaction.
    IntActiQ8IZF4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZF4.
    SMRiQ8IZF4. Positions 283-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 250229ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini272 – 29019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini312 – 32312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini345 – 3539CytoplasmicSequence Analysis
    Topological domaini375 – 41339ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini435 – 45622CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini480 – 4823ExtracellularSequence Analysis
    Topological domaini506 – 52823CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei251 – 27121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei354 – 37421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei414 – 43421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei457 – 47923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei483 – 50523Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini186 – 23853GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG244753.
    HOGENOMiHOG000015136.
    HOVERGENiHBG107961.
    KOiK08459.
    OMAiFLFLWFC.
    OrthoDBiEOG776SPS.
    PhylomeDBiQ8IZF4.
    TreeFamiTF321769.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR003910. GPCR_2_orphan_rcpt_GPR56.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01422. GPR56ORPHANR.
    SMARTiSM00303. GPS. 1 hit.
    [Graphical view]
    PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8IZF4-1 [UniParc]FASTAAdd to Basket

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    MDHCGALFLC LCLLTLQNAT TETWEELLSY MENMQVSRGR SSVFSSRQLH    50
    QLEQMLLNTS FPGYNLTLQT PTIQSLAFKL SCDFSGLSLT SATLKRVPQA 100
    GGQHARGQHA MQFPAELTRD ACKTRPRELR LICIYFSNTH FFKDENNSSL 150
    LNNYVLGAQL SHGHVNNLRD PVNISFWHNQ SLEGYTLTCV FWKEGARKQP 200
    WGGWSPEGCR TEQPSHSQVL CRCNHLTYFA VLMQLSPALV PAELLAPLTY 250
    ISLVGCSISI VASLITVLLH FHFRKQSDSL TRIHMNLHAS VLLLNIAFLL 300
    SPAFAMSPVP GSACTALAAA LHYALLSCLT WMAIEGFNLY LLLGRVYNIY 350
    IRRYVFKLGV LGWGAPALLV LLSLSVKSSV YGPCTIPVFD SWENGTGFQN 400
    MSICWVRSPV VHSVLVMGYG GLTSLFNLVV LAWALWTLRR LRERADAPSV 450
    RACHDTVTVL GLTVLLGTTW ALAFFSFGVF LLPQLFLFTI LNSLYGFFLF 500
    LWFCSQRCRS EAEAKAQIEA FSSSQTTQ 528
    Length:528
    Mass (Da):59,000
    Last modified:May 29, 2007 - v3
    Checksum:i35DE5E5C34FD2A3C
    GO

    Sequence cautioni

    The sequence BAD18748.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAN46670.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti177 – 1826WHNQSL → PSISTQ in BAD18711. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358447 mRNA. Translation: AAQ88812.1.
    AK128298 mRNA. Translation: BAG54657.1.
    AK172765 mRNA. Translation: BAD18748.1. Different initiation.
    AK160368 mRNA. Translation: BAD18711.1.
    CH471092 Genomic DNA. Translation: EAW82936.1.
    BC032401 mRNA. Translation: AAH32401.1.
    AY255609 mRNA. Translation: AAO85121.1.
    AY140956 mRNA. Translation: AAN46670.1. Sequence problems.
    CCDSiCCDS10785.1.
    RefSeqiNP_722579.1. NM_153837.1.
    XP_005255893.1. XM_005255836.1.
    XP_006721232.1. XM_006721169.1.
    UniGeneiHs.187884.

    Genome annotation databases

    EnsembliENST00000340339; ENSP00000342981; ENSG00000159618.
    ENST00000349457; ENSP00000290823; ENSG00000159618.
    GeneIDi221188.
    KEGGihsa:221188.
    UCSCiuc002elx.4. human.

    Polymorphism databases

    DMDMi148886621.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358447 mRNA. Translation: AAQ88812.1 .
    AK128298 mRNA. Translation: BAG54657.1 .
    AK172765 mRNA. Translation: BAD18748.1 . Different initiation.
    AK160368 mRNA. Translation: BAD18711.1 .
    CH471092 Genomic DNA. Translation: EAW82936.1 .
    BC032401 mRNA. Translation: AAH32401.1 .
    AY255609 mRNA. Translation: AAO85121.1 .
    AY140956 mRNA. Translation: AAN46670.1 . Sequence problems.
    CCDSi CCDS10785.1.
    RefSeqi NP_722579.1. NM_153837.1.
    XP_005255893.1. XM_005255836.1.
    XP_006721232.1. XM_006721169.1.
    UniGenei Hs.187884.

    3D structure databases

    ProteinModelPortali Q8IZF4.
    SMRi Q8IZF4. Positions 283-504.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128696. 1 interaction.
    IntActi Q8IZF4. 1 interaction.

    Protein family/group databases

    MEROPSi S63.019.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8IZF4.

    Polymorphism databases

    DMDMi 148886621.

    Proteomic databases

    PaxDbi Q8IZF4.
    PRIDEi Q8IZF4.

    Protocols and materials databases

    DNASUi 221188.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340339 ; ENSP00000342981 ; ENSG00000159618 .
    ENST00000349457 ; ENSP00000290823 ; ENSG00000159618 .
    GeneIDi 221188.
    KEGGi hsa:221188.
    UCSCi uc002elx.4. human.

    Organism-specific databases

    CTDi 221188.
    GeneCardsi GC16P057576.
    HGNCi HGNC:19010. GPR114.
    HPAi HPA007133.
    neXtProti NX_Q8IZF4.
    PharmGKBi PA134896363.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG244753.
    HOGENOMi HOG000015136.
    HOVERGENi HBG107961.
    KOi K08459.
    OMAi FLFLWFC.
    OrthoDBi EOG776SPS.
    PhylomeDBi Q8IZF4.
    TreeFami TF321769.

    Miscellaneous databases

    GeneWikii GPR114.
    GenomeRNAii 221188.
    NextBioi 91231.
    PROi Q8IZF4.

    Gene expression databases

    Bgeei Q8IZF4.
    CleanExi HS_GPR114.
    Genevestigatori Q8IZF4.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR003910. GPCR_2_orphan_rcpt_GPR56.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01422. GPR56ORPHANR.
    SMARTi SM00303. GPS. 1 hit.
    [Graphical view ]
    PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon, Spleen and Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-225.
    6. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
      Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
      FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiGP114_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZF4
    Secondary accession number(s): B3KXZ5
    , Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3