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Q8IZF4

- GP114_HUMAN

UniProt

Q8IZF4 - GP114_HUMAN

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Protein
Probable G-protein coupled receptor 114
Gene
GPR114, PGR27, UNQ2524/PRO6017
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.019.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 114
Alternative name(s):
G-protein coupled receptor PGR27
Gene namesi
Name:GPR114
Synonyms:PGR27
ORF Names:UNQ2524/PRO6017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:19010. GPR114.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 250229Extracellular Reviewed prediction
Add
BLAST
Transmembranei251 – 27121Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini272 – 29019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei291 – 31121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini312 – 32312Extracellular Reviewed prediction
Add
BLAST
Transmembranei324 – 34421Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini345 – 3539Cytoplasmic Reviewed prediction
Transmembranei354 – 37421Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini375 – 41339Extracellular Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini435 – 45622Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei457 – 47923Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini480 – 4823Extracellular Reviewed prediction
Transmembranei483 – 50523Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini506 – 52823Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 528507Probable G-protein coupled receptor 114
PRO_0000012894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi65 – 651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi146 – 1461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi394 – 3941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi400 – 4001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZF4.
PRIDEiQ8IZF4.

PTM databases

PhosphoSiteiQ8IZF4.

Expressioni

Gene expression databases

BgeeiQ8IZF4.
CleanExiHS_GPR114.
GenevestigatoriQ8IZF4.

Organism-specific databases

HPAiHPA007133.

Interactioni

Protein-protein interaction databases

BioGridi128696. 1 interaction.
IntActiQ8IZF4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8IZF4.
SMRiQ8IZF4. Positions 283-504.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 23853GPS
Add
BLAST

Sequence similaritiesi

Contains 1 GPS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG244753.
HOGENOMiHOG000015136.
HOVERGENiHBG107961.
KOiK08459.
OMAiFLFLWFC.
OrthoDBiEOG776SPS.
PhylomeDBiQ8IZF4.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR003910. GPCR_2_orphan_rcpt_GPR56.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZF4-1 [UniParc]FASTAAdd to Basket

« Hide

MDHCGALFLC LCLLTLQNAT TETWEELLSY MENMQVSRGR SSVFSSRQLH    50
QLEQMLLNTS FPGYNLTLQT PTIQSLAFKL SCDFSGLSLT SATLKRVPQA 100
GGQHARGQHA MQFPAELTRD ACKTRPRELR LICIYFSNTH FFKDENNSSL 150
LNNYVLGAQL SHGHVNNLRD PVNISFWHNQ SLEGYTLTCV FWKEGARKQP 200
WGGWSPEGCR TEQPSHSQVL CRCNHLTYFA VLMQLSPALV PAELLAPLTY 250
ISLVGCSISI VASLITVLLH FHFRKQSDSL TRIHMNLHAS VLLLNIAFLL 300
SPAFAMSPVP GSACTALAAA LHYALLSCLT WMAIEGFNLY LLLGRVYNIY 350
IRRYVFKLGV LGWGAPALLV LLSLSVKSSV YGPCTIPVFD SWENGTGFQN 400
MSICWVRSPV VHSVLVMGYG GLTSLFNLVV LAWALWTLRR LRERADAPSV 450
RACHDTVTVL GLTVLLGTTW ALAFFSFGVF LLPQLFLFTI LNSLYGFFLF 500
LWFCSQRCRS EAEAKAQIEA FSSSQTTQ 528
Length:528
Mass (Da):59,000
Last modified:May 29, 2007 - v3
Checksum:i35DE5E5C34FD2A3C
GO

Sequence cautioni

The sequence BAD18748.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAN46670.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1826WHNQSL → PSISTQ in BAD18711. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358447 mRNA. Translation: AAQ88812.1.
AK128298 mRNA. Translation: BAG54657.1.
AK172765 mRNA. Translation: BAD18748.1. Different initiation.
AK160368 mRNA. Translation: BAD18711.1.
CH471092 Genomic DNA. Translation: EAW82936.1.
BC032401 mRNA. Translation: AAH32401.1.
AY255609 mRNA. Translation: AAO85121.1.
AY140956 mRNA. Translation: AAN46670.1. Sequence problems.
CCDSiCCDS10785.1.
RefSeqiNP_722579.1. NM_153837.1.
XP_005255893.1. XM_005255836.1.
XP_006721232.1. XM_006721169.1.
UniGeneiHs.187884.

Genome annotation databases

EnsembliENST00000340339; ENSP00000342981; ENSG00000159618.
ENST00000349457; ENSP00000290823; ENSG00000159618.
GeneIDi221188.
KEGGihsa:221188.
UCSCiuc002elx.4. human.

Polymorphism databases

DMDMi148886621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358447 mRNA. Translation: AAQ88812.1 .
AK128298 mRNA. Translation: BAG54657.1 .
AK172765 mRNA. Translation: BAD18748.1 . Different initiation.
AK160368 mRNA. Translation: BAD18711.1 .
CH471092 Genomic DNA. Translation: EAW82936.1 .
BC032401 mRNA. Translation: AAH32401.1 .
AY255609 mRNA. Translation: AAO85121.1 .
AY140956 mRNA. Translation: AAN46670.1 . Sequence problems.
CCDSi CCDS10785.1.
RefSeqi NP_722579.1. NM_153837.1.
XP_005255893.1. XM_005255836.1.
XP_006721232.1. XM_006721169.1.
UniGenei Hs.187884.

3D structure databases

ProteinModelPortali Q8IZF4.
SMRi Q8IZF4. Positions 283-504.
ModBasei Search...

Protein-protein interaction databases

BioGridi 128696. 1 interaction.
IntActi Q8IZF4. 1 interaction.

Protein family/group databases

MEROPSi S63.019.
GPCRDBi Search...

PTM databases

PhosphoSitei Q8IZF4.

Polymorphism databases

DMDMi 148886621.

Proteomic databases

PaxDbi Q8IZF4.
PRIDEi Q8IZF4.

Protocols and materials databases

DNASUi 221188.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340339 ; ENSP00000342981 ; ENSG00000159618 .
ENST00000349457 ; ENSP00000290823 ; ENSG00000159618 .
GeneIDi 221188.
KEGGi hsa:221188.
UCSCi uc002elx.4. human.

Organism-specific databases

CTDi 221188.
GeneCardsi GC16P057576.
HGNCi HGNC:19010. GPR114.
HPAi HPA007133.
neXtProti NX_Q8IZF4.
PharmGKBi PA134896363.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG244753.
HOGENOMi HOG000015136.
HOVERGENi HBG107961.
KOi K08459.
OMAi FLFLWFC.
OrthoDBi EOG776SPS.
PhylomeDBi Q8IZF4.
TreeFami TF321769.

Miscellaneous databases

GeneWikii GPR114.
GenomeRNAii 221188.
NextBioi 91231.
PROi Q8IZF4.

Gene expression databases

Bgeei Q8IZF4.
CleanExi HS_GPR114.
Genevestigatori Q8IZF4.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR003910. GPCR_2_orphan_rcpt_GPR56.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01422. GPR56ORPHANR.
SMARTi SM00303. GPS. 1 hit.
[Graphical view ]
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Spleen and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-225.
  6. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
    Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
    FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiGP114_HUMAN
AccessioniPrimary (citable) accession number: Q8IZF4
Secondary accession number(s): B3KXZ5
, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 29, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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