Q8IZF3 (GP115_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 115

Alternative name(s):
G-protein coupled receptor PGR18

Gene names

Name:	GPR115
Synonyms:	PGR18

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	695 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain.
Sequence caution	The sequence AAN46671.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAC45257.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI15579.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement PubMed 15203201. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15203201. Source: GDB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 695	674	Probable G-protein coupled receptor 115		PRO_0000070336
Regions
	Topological domain	22 – 406	385	Extracellular Potential
	Transmembrane	407 – 427	21	Helical; Name=1; Potential
	Topological domain	428 – 440	13	Cytoplasmic Potential
	Transmembrane	441 – 461	21	Helical; Name=2; Potential
	Topological domain	462 – 485	24	Extracellular Potential
	Transmembrane	486 – 506	21	Helical; Name=3; Potential
	Topological domain	507 – 515	9	Cytoplasmic Potential
	Transmembrane	516 – 536	21	Helical; Name=4; Potential
	Topological domain	537 – 561	25	Extracellular Potential
	Transmembrane	562 – 582	21	Helical; Name=5; Potential
	Topological domain	583 – 606	24	Cytoplasmic Potential
	Transmembrane	607 – 627	21	Helical; Name=6; Potential
	Topological domain	628 – 634	7	Extracellular Potential
	Transmembrane	635 – 655	21	Helical; Name=7; Potential
	Topological domain	656 – 695	40	Cytoplasmic Potential
	Domain	346 – 396	51	GPS
Amino acid modifications
	Glycosylation	61	1	N-linked (GlcNAc...) Potential
	Glycosylation	169	1	N-linked (GlcNAc...) Potential
	Glycosylation	177	1	N-linked (GlcNAc...) Potential
	Glycosylation	209	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
	Glycosylation	250	1	N-linked (GlcNAc...) Potential
	Glycosylation	257	1	N-linked (GlcNAc...) Potential
	Glycosylation	263	1	N-linked (GlcNAc...) Potential
	Glycosylation	264	1	N-linked (GlcNAc...) Potential
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Glycosylation	309	1	N-linked (GlcNAc...) Potential
	Glycosylation	340	1	N-linked (GlcNAc...) Potential
	Glycosylation	379	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	507	1	R → C. Corresponds to variant rs12110938 [ dbSNP | Ensembl ].		VAR_055930
	Natural variant	541	1	K → N. Ref.1 Ref.3 Ref.5 Corresponds to variant rs9369738 [ dbSNP | Ensembl ].		VAR_024476
	Natural variant	674	1	S → L in a breast cancer sample; somatic mutation. Ref.8		VAR_036224
Experimental info
	Sequence conflict	491	1	M → I in AAO85068. Ref.6
	Sequence conflict	538 – 540	3	EPE → GPV in AAO85068. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q8IZF3 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: B902221DD0804D0E	FASTA	695	77,719
	10 20 30 40 50 60 MKMKSQATMI CCLVFFLSTE CSHYRSKIHL KAGDKLQSPE GKPKTGRIQE KCEGPCISSS 70 80 90 100 110 120 NCSQPCAKDF HGEIGFTCNQ KKWQKSAETC TSLSVEKLFK DSTGASRLSV AAPSIPLHIL 130 140 150 160 170 180 DFRAPETIES VAQGIRKNCP FDYACITDMV KSSETTSGNI AFIVELLKNI STDLSDNVTR 190 200 210 220 230 240 EKMKSYSEVA NHILDTAAIS NWAFIPNKNA SSDLLQSVNL FARQLHIHNN SENIVNELFI 250 260 270 280 290 300 QTKGFHINHN TSEKSLNFSM SMNNTTEDIL GMVQIPRQEL RKLWPNASQA ISIAFPTLGA 310 320 330 340 350 360 ILREAHLQNV SLPRQVNGLV LSVVLPERLQ EIILTFEKIN KTRNARAQCV GWHSKKRRWD 370 380 390 400 410 420 EKACQMMLDI RNEVKCRCNY TSVVMSFSIL MSSKSMTDKV LDYITCIGLS VSILSLVLCL 430 440 450 460 470 480 IIEATVWSRV VVTEISYMRH VCIVNIAVSL LTANVWFIIG SHFNIKAQDY NMCVAVTFFS 490 500 510 520 530 540 HFFYLSLFFW MLFKALLIIY GILVIFRRMM KSRMMVIGFA IGYGCPLIIA VTTVAITEPE 550 560 570 580 590 600 KGYMRPEACW LNWDNTKALL AFAIPAFVIV AVNLIVVLVV AVNTQRPSIG SSKSQDVVII 610 620 630 640 650 660 MRISKNVAIL TPLLGLTWGF GIATLIEGTS LTFHIIFALL NAFQGFFILL FGTIMDHKIR 670 680 690 DALRMRMSSL KGKSRAAENA SLGPTNGSKL MNRQG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete coding sequence of GPR115." Bonner T.I., Kauffman D., Nagle J.W., Sloger M. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-541. Tissue: Testis.
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-541. Tissue: Tongue.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-541.
[6]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-589.
[7]	"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions." Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B. FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-674.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ315370 mRNA. Translation: ABC41929.1. AB065474 Genomic DNA. Translation: BAC45257.1. Sequence problems. AK095395 mRNA. Translation: BAG53042.1. AL356421 Genomic DNA. Translation: CAI15579.1. Sequence problems. AL356421 Genomic DNA. Translation: CAI15581.1. CH471081 Genomic DNA. Translation: EAX04321.1. AY255556 mRNA. Translation: AAO85068.1. AY140957 mRNA. Translation: AAN46671.1. Sequence problems.
IPI	IPI00217512.
RefSeq	NP_722580.3. NM_153838.3.
UniGene	Hs.150131.
3D structure databases
ProteinModelPortal	Q8IZF3.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8IZF3.
Polymorphism databases
DMDM	296439339.
Proteomic databases
PaxDb	Q8IZF3.
PRIDE	Q8IZF3.
Protocols and materials databases
DNASU	221393.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000283303; ENSP00000283303; ENSG00000153294. ENST00000327753; ENSP00000328319; ENSG00000153294. ENST00000371220; ENSP00000360264; ENSG00000153294.
GeneID	221393.
KEGG	hsa:221393.
UCSC	uc003oyz.1. human.
Organism-specific databases
CTD	221393.
GeneCards	GC06P047653.
HGNC	HGNC:19011. GPR115.
HPA	HPA007158.
neXtProt	NX_Q8IZF3.
PharmGKB	PA134954617.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG313007.
HOVERGEN	HBG051768.
KO	K08457.
Gene expression databases
Bgee	Q8IZF3.
CleanEx	HS_GPR115.
Genevestigator	Q8IZF3.
GermOnline	ENSG00000153294. Homo sapiens.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR008078. GPCR_2_Ig-hepta_rcpt. IPR000832. GPCR_2_secretin-like. IPR000203. GPS_dom. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN. PR01695. IGHEPTARCPTR.
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GPR115. human.
GenomeRNAi	221393.
NextBio	91307.

Entry information

Entry name

GP115_HUMAN

Accession

Primary (citable) accession number: Q8IZF3
Secondary accession number(s): B3KTD0 , Q2PNZ0, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.