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Q8IZF3

- GP115_HUMAN

UniProt

Q8IZF3 - GP115_HUMAN

Protein

Probable G-protein coupled receptor 115

Gene

GPR115

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 115
    Alternative name(s):
    G-protein coupled receptor PGR18
    Gene namesi
    Name:GPR115
    Synonyms:PGR18
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:19011. GPR115.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134954617.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 695674Probable G-protein coupled receptor 115PRO_0000070336Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8IZF3.
    PRIDEiQ8IZF3.

    PTM databases

    PhosphoSiteiQ8IZF3.

    Expressioni

    Gene expression databases

    BgeeiQ8IZF3.
    CleanExiHS_GPR115.
    GenevestigatoriQ8IZF3.

    Organism-specific databases

    HPAiHPA007158.

    Interactioni

    Protein-protein interaction databases

    BioGridi128718. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZF3.
    SMRiQ8IZF3. Positions 404-656.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 406385ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini428 – 44013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini462 – 48524ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini507 – 5159CytoplasmicSequence Analysis
    Topological domaini537 – 56125ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini583 – 60624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini628 – 6347ExtracellularSequence Analysis
    Topological domaini656 – 69540CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei407 – 42721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei441 – 46121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei486 – 50621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei516 – 53621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei562 – 58221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei607 – 62721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei635 – 65521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini346 – 39651GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG313007.
    HOVERGENiHBG051768.
    KOiK08457.
    OrthoDBiEOG7GJ6CK.
    PhylomeDBiQ8IZF3.
    TreeFamiTF316380.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR008078. GPCR_2_Ig-hepta_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01695. IGHEPTARCPTR.
    PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8IZF3-1 [UniParc]FASTAAdd to Basket

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    MKMKSQATMI CCLVFFLSTE CSHYRSKIHL KAGDKLQSPE GKPKTGRIQE    50
    KCEGPCISSS NCSQPCAKDF HGEIGFTCNQ KKWQKSAETC TSLSVEKLFK 100
    DSTGASRLSV AAPSIPLHIL DFRAPETIES VAQGIRKNCP FDYACITDMV 150
    KSSETTSGNI AFIVELLKNI STDLSDNVTR EKMKSYSEVA NHILDTAAIS 200
    NWAFIPNKNA SSDLLQSVNL FARQLHIHNN SENIVNELFI QTKGFHINHN 250
    TSEKSLNFSM SMNNTTEDIL GMVQIPRQEL RKLWPNASQA ISIAFPTLGA 300
    ILREAHLQNV SLPRQVNGLV LSVVLPERLQ EIILTFEKIN KTRNARAQCV 350
    GWHSKKRRWD EKACQMMLDI RNEVKCRCNY TSVVMSFSIL MSSKSMTDKV 400
    LDYITCIGLS VSILSLVLCL IIEATVWSRV VVTEISYMRH VCIVNIAVSL 450
    LTANVWFIIG SHFNIKAQDY NMCVAVTFFS HFFYLSLFFW MLFKALLIIY 500
    GILVIFRRMM KSRMMVIGFA IGYGCPLIIA VTTVAITEPE KGYMRPEACW 550
    LNWDNTKALL AFAIPAFVIV AVNLIVVLVV AVNTQRPSIG SSKSQDVVII 600
    MRISKNVAIL TPLLGLTWGF GIATLIEGTS LTFHIIFALL NAFQGFFILL 650
    FGTIMDHKIR DALRMRMSSL KGKSRAAENA SLGPTNGSKL MNRQG 695
    Length:695
    Mass (Da):77,719
    Last modified:May 18, 2010 - v3
    Checksum:iB902221DD0804D0E
    GO

    Sequence cautioni

    The sequence AAN46671.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence BAC45257.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI15579.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti491 – 4911M → I in AAO85068. (PubMed:12679517)Curated
    Sequence conflicti538 – 5403EPE → GPV in AAO85068. (PubMed:12679517)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti507 – 5071R → C.
    Corresponds to variant rs12110938 [ dbSNP | Ensembl ].
    VAR_055930
    Natural varianti541 – 5411K → N.3 Publications
    Corresponds to variant rs9369738 [ dbSNP | Ensembl ].
    VAR_024476
    Natural varianti674 – 6741S → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036224

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ315370 mRNA. Translation: ABC41929.1.
    AB065474 Genomic DNA. Translation: BAC45257.1. Sequence problems.
    AK095395 mRNA. Translation: BAG53042.1.
    AL356421 Genomic DNA. Translation: CAI15579.1. Sequence problems.
    AL356421 Genomic DNA. Translation: CAI15581.1.
    CH471081 Genomic DNA. Translation: EAX04321.1.
    AY255556 mRNA. Translation: AAO85068.1.
    AY140957 mRNA. Translation: AAN46671.1. Sequence problems.
    CCDSiCCDS4922.2.
    RefSeqiNP_722580.3. NM_153838.3.
    UniGeneiHs.150131.

    Genome annotation databases

    EnsembliENST00000283303; ENSP00000283303; ENSG00000153294.
    ENST00000327753; ENSP00000328319; ENSG00000153294.
    ENST00000371220; ENSP00000360264; ENSG00000153294.
    GeneIDi221393.
    KEGGihsa:221393.
    UCSCiuc003oyz.1. human.

    Polymorphism databases

    DMDMi296439339.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ315370 mRNA. Translation: ABC41929.1 .
    AB065474 Genomic DNA. Translation: BAC45257.1 . Sequence problems.
    AK095395 mRNA. Translation: BAG53042.1 .
    AL356421 Genomic DNA. Translation: CAI15579.1 . Sequence problems.
    AL356421 Genomic DNA. Translation: CAI15581.1 .
    CH471081 Genomic DNA. Translation: EAX04321.1 .
    AY255556 mRNA. Translation: AAO85068.1 .
    AY140957 mRNA. Translation: AAN46671.1 . Sequence problems.
    CCDSi CCDS4922.2.
    RefSeqi NP_722580.3. NM_153838.3.
    UniGenei Hs.150131.

    3D structure databases

    ProteinModelPortali Q8IZF3.
    SMRi Q8IZF3. Positions 404-656.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128718. 1 interaction.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8IZF3.

    Polymorphism databases

    DMDMi 296439339.

    Proteomic databases

    PaxDbi Q8IZF3.
    PRIDEi Q8IZF3.

    Protocols and materials databases

    DNASUi 221393.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283303 ; ENSP00000283303 ; ENSG00000153294 .
    ENST00000327753 ; ENSP00000328319 ; ENSG00000153294 .
    ENST00000371220 ; ENSP00000360264 ; ENSG00000153294 .
    GeneIDi 221393.
    KEGGi hsa:221393.
    UCSCi uc003oyz.1. human.

    Organism-specific databases

    CTDi 221393.
    GeneCardsi GC06P047653.
    HGNCi HGNC:19011. GPR115.
    HPAi HPA007158.
    neXtProti NX_Q8IZF3.
    PharmGKBi PA134954617.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313007.
    HOVERGENi HBG051768.
    KOi K08457.
    OrthoDBi EOG7GJ6CK.
    PhylomeDBi Q8IZF3.
    TreeFami TF316380.

    Miscellaneous databases

    ChiTaRSi GPR115. human.
    GeneWikii GPR115.
    GenomeRNAii 221393.
    NextBioi 91307.
    PROi Q8IZF3.

    Gene expression databases

    Bgeei Q8IZF3.
    CleanExi HS_GPR115.
    Genevestigatori Q8IZF3.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR008078. GPCR_2_Ig-hepta_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01695. IGHEPTARCPTR.
    PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete coding sequence of GPR115."
      Bonner T.I., Kauffman D., Nagle J.W., Sloger M.
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-541.
      Tissue: Testis.
    2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-541.
      Tissue: Tongue.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-541.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-589.
    7. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
      Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
      FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-674.

    Entry informationi

    Entry nameiGP115_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZF3
    Secondary accession number(s): B3KTD0
    , Q2PNZ0, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3