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Protein

Probable G-protein coupled receptor 115

Gene

GPR115

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 115
Alternative name(s):
G-protein coupled receptor PGR18
Gene namesi
Name:GPR115
Synonyms:PGR18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19011. GPR115.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 406385ExtracellularSequence AnalysisAdd
BLAST
Transmembranei407 – 42721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini428 – 44013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei441 – 46121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini462 – 48524ExtracellularSequence AnalysisAdd
BLAST
Transmembranei486 – 50621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini507 – 5159CytoplasmicSequence Analysis
Transmembranei516 – 53621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini537 – 56125ExtracellularSequence AnalysisAdd
BLAST
Transmembranei562 – 58221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini583 – 60624CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei607 – 62721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini628 – 6347ExtracellularSequence Analysis
Transmembranei635 – 65521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini656 – 69540CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134954617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 695674Probable G-protein coupled receptor 115PRO_0000070336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IZF3.
PRIDEiQ8IZF3.

PTM databases

PhosphoSiteiQ8IZF3.

Expressioni

Gene expression databases

BgeeiQ8IZF3.
CleanExiHS_GPR115.
GenevestigatoriQ8IZF3.

Organism-specific databases

HPAiHPA007158.

Interactioni

Protein-protein interaction databases

BioGridi128718. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8IZF3.
SMRiQ8IZF3. Positions 404-656.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini346 – 39651GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313007.
GeneTreeiENSGT00780000121893.
HOVERGENiHBG051768.
InParanoidiQ8IZF3.
KOiK08457.
OrthoDBiEOG7GJ6CK.
PhylomeDBiQ8IZF3.
TreeFamiTF316380.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMKSQATMI CCLVFFLSTE CSHYRSKIHL KAGDKLQSPE GKPKTGRIQE
60 70 80 90 100
KCEGPCISSS NCSQPCAKDF HGEIGFTCNQ KKWQKSAETC TSLSVEKLFK
110 120 130 140 150
DSTGASRLSV AAPSIPLHIL DFRAPETIES VAQGIRKNCP FDYACITDMV
160 170 180 190 200
KSSETTSGNI AFIVELLKNI STDLSDNVTR EKMKSYSEVA NHILDTAAIS
210 220 230 240 250
NWAFIPNKNA SSDLLQSVNL FARQLHIHNN SENIVNELFI QTKGFHINHN
260 270 280 290 300
TSEKSLNFSM SMNNTTEDIL GMVQIPRQEL RKLWPNASQA ISIAFPTLGA
310 320 330 340 350
ILREAHLQNV SLPRQVNGLV LSVVLPERLQ EIILTFEKIN KTRNARAQCV
360 370 380 390 400
GWHSKKRRWD EKACQMMLDI RNEVKCRCNY TSVVMSFSIL MSSKSMTDKV
410 420 430 440 450
LDYITCIGLS VSILSLVLCL IIEATVWSRV VVTEISYMRH VCIVNIAVSL
460 470 480 490 500
LTANVWFIIG SHFNIKAQDY NMCVAVTFFS HFFYLSLFFW MLFKALLIIY
510 520 530 540 550
GILVIFRRMM KSRMMVIGFA IGYGCPLIIA VTTVAITEPE KGYMRPEACW
560 570 580 590 600
LNWDNTKALL AFAIPAFVIV AVNLIVVLVV AVNTQRPSIG SSKSQDVVII
610 620 630 640 650
MRISKNVAIL TPLLGLTWGF GIATLIEGTS LTFHIIFALL NAFQGFFILL
660 670 680 690
FGTIMDHKIR DALRMRMSSL KGKSRAAENA SLGPTNGSKL MNRQG
Length:695
Mass (Da):77,719
Last modified:May 17, 2010 - v3
Checksum:iB902221DD0804D0E
GO

Sequence cautioni

The sequence AAN46671.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAC45257.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI15579.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti491 – 4911M → I in AAO85068 (PubMed:12679517).Curated
Sequence conflicti538 – 5403EPE → GPV in AAO85068 (PubMed:12679517).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti507 – 5071R → C.
Corresponds to variant rs12110938 [ dbSNP | Ensembl ].
VAR_055930
Natural varianti541 – 5411K → N.3 Publications
Corresponds to variant rs9369738 [ dbSNP | Ensembl ].
VAR_024476
Natural varianti674 – 6741S → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_036224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ315370 mRNA. Translation: ABC41929.1.
AB065474 Genomic DNA. Translation: BAC45257.1. Sequence problems.
AK095395 mRNA. Translation: BAG53042.1.
AL356421 Genomic DNA. Translation: CAI15579.1. Sequence problems.
AL356421 Genomic DNA. Translation: CAI15581.1.
CH471081 Genomic DNA. Translation: EAX04321.1.
AY255556 mRNA. Translation: AAO85068.1.
AY140957 mRNA. Translation: AAN46671.1. Sequence problems.
CCDSiCCDS4922.2.
RefSeqiNP_722580.3. NM_153838.3.
UniGeneiHs.150131.

Genome annotation databases

EnsembliENST00000283303; ENSP00000283303; ENSG00000153294.
ENST00000327753; ENSP00000328319; ENSG00000153294.
GeneIDi221393.
KEGGihsa:221393.
UCSCiuc003oyz.1. human.

Polymorphism databases

DMDMi296439339.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ315370 mRNA. Translation: ABC41929.1.
AB065474 Genomic DNA. Translation: BAC45257.1. Sequence problems.
AK095395 mRNA. Translation: BAG53042.1.
AL356421 Genomic DNA. Translation: CAI15579.1. Sequence problems.
AL356421 Genomic DNA. Translation: CAI15581.1.
CH471081 Genomic DNA. Translation: EAX04321.1.
AY255556 mRNA. Translation: AAO85068.1.
AY140957 mRNA. Translation: AAN46671.1. Sequence problems.
CCDSiCCDS4922.2.
RefSeqiNP_722580.3. NM_153838.3.
UniGeneiHs.150131.

3D structure databases

ProteinModelPortaliQ8IZF3.
SMRiQ8IZF3. Positions 404-656.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128718. 1 interaction.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8IZF3.

Polymorphism databases

DMDMi296439339.

Proteomic databases

PaxDbiQ8IZF3.
PRIDEiQ8IZF3.

Protocols and materials databases

DNASUi221393.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283303; ENSP00000283303; ENSG00000153294.
ENST00000327753; ENSP00000328319; ENSG00000153294.
GeneIDi221393.
KEGGihsa:221393.
UCSCiuc003oyz.1. human.

Organism-specific databases

CTDi221393.
GeneCardsiGC06P047653.
HGNCiHGNC:19011. GPR115.
HPAiHPA007158.
neXtProtiNX_Q8IZF3.
PharmGKBiPA134954617.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG313007.
GeneTreeiENSGT00780000121893.
HOVERGENiHBG051768.
InParanoidiQ8IZF3.
KOiK08457.
OrthoDBiEOG7GJ6CK.
PhylomeDBiQ8IZF3.
TreeFamiTF316380.

Miscellaneous databases

ChiTaRSiGPR115. human.
GeneWikiiGPR115.
GenomeRNAii221393.
NextBioi91307.
PROiQ8IZF3.

Gene expression databases

BgeeiQ8IZF3.
CleanExiHS_GPR115.
GenevestigatoriQ8IZF3.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequence of GPR115."
    Bonner T.I., Kauffman D., Nagle J.W., Sloger M.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-541.
    Tissue: Testis.
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-541.
    Tissue: Tongue.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-541.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-589.
  7. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
    Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
    FEBS Lett. 531:407-414(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-674.

Entry informationi

Entry nameiGP115_HUMAN
AccessioniPrimary (citable) accession number: Q8IZF3
Secondary accession number(s): B3KTD0
, Q2PNZ0, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 14, 2005
Last sequence update: May 17, 2010
Last modified: March 3, 2015
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.