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Q8IZF3 (GP115_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 115
Alternative name(s):
G-protein coupled receptor PGR18
Gene names
Name:GPR115
Synonyms:PGR18
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Sequence caution

The sequence AAN46671.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAC45257.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI15579.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 695674Probable G-protein coupled receptor 115
PRO_0000070336

Regions

Topological domain22 – 406385Extracellular Potential
Transmembrane407 – 42721Helical; Name=1; Potential
Topological domain428 – 44013Cytoplasmic Potential
Transmembrane441 – 46121Helical; Name=2; Potential
Topological domain462 – 48524Extracellular Potential
Transmembrane486 – 50621Helical; Name=3; Potential
Topological domain507 – 5159Cytoplasmic Potential
Transmembrane516 – 53621Helical; Name=4; Potential
Topological domain537 – 56125Extracellular Potential
Transmembrane562 – 58221Helical; Name=5; Potential
Topological domain583 – 60624Cytoplasmic Potential
Transmembrane607 – 62721Helical; Name=6; Potential
Topological domain628 – 6347Extracellular Potential
Transmembrane635 – 65521Helical; Name=7; Potential
Topological domain656 – 69540Cytoplasmic Potential
Domain346 – 39651GPS

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation2091N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation2571N-linked (GlcNAc...) Potential
Glycosylation2631N-linked (GlcNAc...) Potential
Glycosylation2641N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential
Glycosylation3091N-linked (GlcNAc...) Potential
Glycosylation3401N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential

Natural variations

Natural variant5071R → C.
Corresponds to variant rs12110938 [ dbSNP | Ensembl ].
VAR_055930
Natural variant5411K → N. Ref.1 Ref.3 Ref.5
Corresponds to variant rs9369738 [ dbSNP | Ensembl ].
VAR_024476
Natural variant6741S → L in a breast cancer sample; somatic mutation. Ref.8
VAR_036224

Experimental info

Sequence conflict4911M → I in AAO85068. Ref.6
Sequence conflict538 – 5403EPE → GPV in AAO85068. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q8IZF3 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: B902221DD0804D0E

FASTA69577,719
        10         20         30         40         50         60 
MKMKSQATMI CCLVFFLSTE CSHYRSKIHL KAGDKLQSPE GKPKTGRIQE KCEGPCISSS 

        70         80         90        100        110        120 
NCSQPCAKDF HGEIGFTCNQ KKWQKSAETC TSLSVEKLFK DSTGASRLSV AAPSIPLHIL 

       130        140        150        160        170        180 
DFRAPETIES VAQGIRKNCP FDYACITDMV KSSETTSGNI AFIVELLKNI STDLSDNVTR 

       190        200        210        220        230        240 
EKMKSYSEVA NHILDTAAIS NWAFIPNKNA SSDLLQSVNL FARQLHIHNN SENIVNELFI 

       250        260        270        280        290        300 
QTKGFHINHN TSEKSLNFSM SMNNTTEDIL GMVQIPRQEL RKLWPNASQA ISIAFPTLGA 

       310        320        330        340        350        360 
ILREAHLQNV SLPRQVNGLV LSVVLPERLQ EIILTFEKIN KTRNARAQCV GWHSKKRRWD 

       370        380        390        400        410        420 
EKACQMMLDI RNEVKCRCNY TSVVMSFSIL MSSKSMTDKV LDYITCIGLS VSILSLVLCL 

       430        440        450        460        470        480 
IIEATVWSRV VVTEISYMRH VCIVNIAVSL LTANVWFIIG SHFNIKAQDY NMCVAVTFFS 

       490        500        510        520        530        540 
HFFYLSLFFW MLFKALLIIY GILVIFRRMM KSRMMVIGFA IGYGCPLIIA VTTVAITEPE 

       550        560        570        580        590        600 
KGYMRPEACW LNWDNTKALL AFAIPAFVIV AVNLIVVLVV AVNTQRPSIG SSKSQDVVII 

       610        620        630        640        650        660 
MRISKNVAIL TPLLGLTWGF GIATLIEGTS LTFHIIFALL NAFQGFFILL FGTIMDHKIR 

       670        680        690 
DALRMRMSSL KGKSRAAENA SLGPTNGSKL MNRQG 

« Hide

References

« Hide 'large scale' references
[1]"Complete coding sequence of GPR115."
Bonner T.I., Kauffman D., Nagle J.W., Sloger M.
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-541.
Tissue: Testis.
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-541.
Tissue: Tongue.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-541.
[6]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-589.
[7]"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-674.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ315370 mRNA. Translation: ABC41929.1.
AB065474 Genomic DNA. Translation: BAC45257.1. Sequence problems.
AK095395 mRNA. Translation: BAG53042.1.
AL356421 Genomic DNA. Translation: CAI15579.1. Sequence problems.
AL356421 Genomic DNA. Translation: CAI15581.1.
CH471081 Genomic DNA. Translation: EAX04321.1.
AY255556 mRNA. Translation: AAO85068.1.
AY140957 mRNA. Translation: AAN46671.1. Sequence problems.
RefSeqNP_722580.3. NM_153838.3.
UniGeneHs.150131.

3D structure databases

ProteinModelPortalQ8IZF3.
SMRQ8IZF3. Positions 404-656.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128718. 1 interaction.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8IZF3.

Polymorphism databases

DMDM296439339.

Proteomic databases

PaxDbQ8IZF3.
PRIDEQ8IZF3.

Protocols and materials databases

DNASU221393.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283303; ENSP00000283303; ENSG00000153294.
ENST00000327753; ENSP00000328319; ENSG00000153294.
ENST00000371220; ENSP00000360264; ENSG00000153294.
GeneID221393.
KEGGhsa:221393.
UCSCuc003oyz.1. human.

Organism-specific databases

CTD221393.
GeneCardsGC06P047653.
HGNCHGNC:19011. GPR115.
HPAHPA007158.
neXtProtNX_Q8IZF3.
PharmGKBPA134954617.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313007.
HOVERGENHBG051768.
KOK08457.
OrthoDBEOG7GJ6CK.
PhylomeDBQ8IZF3.
TreeFamTF316380.

Gene expression databases

BgeeQ8IZF3.
CleanExHS_GPR115.
GenevestigatorQ8IZF3.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
PROSITEPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPR115. human.
GeneWikiGPR115.
GenomeRNAi221393.
NextBio91307.
PROQ8IZF3.

Entry information

Entry nameGP115_HUMAN
AccessionPrimary (citable) accession number: Q8IZF3
Secondary accession number(s): B3KTD0 expand/collapse secondary AC list , Q2PNZ0, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries