Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8IZF2

- GP116_HUMAN

UniProt

Q8IZF2 - GP116_HUMAN

Protein

Probable G-protein coupled receptor 116

Gene

GPR116

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May have a role in the regulation of acid-base balance.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei226 – 2272CleavageBy similarity
    Sitei990 – 9912CleavageBy similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. energy reserve metabolic process Source: Ensembl
    2. fat cell differentiation Source: Ensembl
    3. glucose homeostasis Source: Ensembl
    4. G-protein coupled receptor signaling pathway Source: GDB
    5. neuropeptide signaling pathway Source: InterPro
    6. regulation of lipid metabolic process Source: Ensembl
    7. surfactant homeostasis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Protein family/group databases

    MEROPSiS63.022.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 116
    Gene namesi
    Name:GPR116
    Synonyms:KIAA0758
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:19030. GPR116.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. cytoplasmic vesicle Source: MGI
    3. integral component of membrane Source: GDB
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134886165.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 13461325Probable G-protein coupled receptor 116PRO_0000012896Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi256 – 2561N-linked (GlcNAc...)1 Publication
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi315 – 3151N-linked (GlcNAc...)1 Publication
    Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi649 – 6491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi666 – 6661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi820 – 8201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi931 – 9311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi963 – 9631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi982 – 9821N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Proteolytically cleaved into 2 highly conserved sites: one in the SEA domain and the other in the stalk domain region preceding the first transmembrane. The later 2 subunits, the extracellular subunit and the seven-transmembrane subunit, remain tightly associated and non-covalently linked By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8IZF2.
    PRIDEiQ8IZF2.

    PTM databases

    PhosphoSiteiQ8IZF2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IZF2.
    BgeeiQ8IZF2.
    CleanExiHS_GPR116.
    GenevestigatoriQ8IZF2.

    Interactioni

    Subunit structurei

    Exists as disulfide-linked dimers at the cell surface.By similarity

    Protein-protein interaction databases

    IntActiQ8IZF2. 1 interaction.
    MINTiMINT-4715450.
    STRINGi9606.ENSP00000265417.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IZF2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 1006985ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1028 – 105326CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1075 – 109016ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1112 – 112817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1150 – 117324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1195 – 122026CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1242 – 12443ExtracellularSequence Analysis
    Topological domaini1266 – 134681CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1007 – 102721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei1054 – 107421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei1091 – 111121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei1129 – 114921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei1174 – 119421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1221 – 124121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1245 – 126521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini166 – 273108SEAPROSITE-ProRule annotationAdd
    BLAST
    Domaini267 – 368102Ig-like 1Add
    BLAST
    Domaini369 – 46698Ig-like 2Add
    BLAST
    Domaini471 – 56191Ig-like 3Add
    BLAST
    Domaini951 – 100252GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 SEA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235397.
    HOGENOMiHOG000112764.
    HOVERGENiHBG051772.
    InParanoidiQ8IZF2.
    KOiK08458.
    OMAiSTPVFSM.
    PhylomeDBiQ8IZF2.
    TreeFamiTF316380.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR017981. GPCR_2-like.
    IPR008078. GPCR_2_Ig-hepta_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR000082. SEA_dom.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    PF07679. I-set. 1 hit.
    PF01390. SEA. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01695. IGHEPTARCPTR.
    SMARTiSM00303. GPS. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00200. SEA. 1 hit.
    [Graphical view]
    SUPFAMiSSF82671. SSF82671. 1 hit.
    PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50835. IG_LIKE. 3 hits.
    PS50024. SEA. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IZF2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSPRRTTLC LMFIVIYSSK AALNWNYEST IHPLSLHEHE PAGEEALRQK     50
    RAVATKSPTA EEYTVNIEIS FENASFLDPI KAYLNSLSFP IHGNNTDQIT 100
    DILSINVTTV CRPAGNEIWC SCETGYGWPR ERCLHNLICQ ERDVFLPGHH 150
    CSCLKELPPN GPFCLLQEDV TLNMRVRLNV GFQEDLMNTS SALYRSYKTD 200
    LETAFRKGYG ILPGFKGVTV TGFKSGSVVV TYEVKTTPPS LELIHKANEQ 250
    VVQSLNQTYK MDYNSFQAVT INESNFFVTP EIIFEGDTVS LVCEKEVLSS 300
    NVSWRYEEQQ LEIQNSSRFS IYTALFNNMT SVSKLTIHNI TPGDAGEYVC 350
    KLILDIFEYE CKKKIDVMPI QILANEEMKV MCDNNPVSLN CCSQGNVNWS 400
    KVEWKQEGKI NIPGTPETDI DSSCSRYTLK ADGTQCPSGS SGTTVIYTCE 450
    FISAYGARGS ANIKVTFISV ANLTITPDPI SVSEGQNFSI KCISDVSNYD 500
    EVYWNTSAGI KIYQRFYTTR RYLDGAESVL TVKTSTREWN GTYHCIFRYK 550
    NSYSIATKDV IVHPLPLKLN IMVDPLEATV SCSGSHHIKC CIEEDGDYKV 600
    TFHTGSSSLP AAKEVNKKQV CYKHNFNASS VSWCSKTVDV CCHFTNAANN 650
    SVWSPSMKLN LVPGENITCQ DPVIGVGEPG KVIQKLCRFS NVPSSPESPI 700
    GGTITYKCVG SQWEEKRNDC ISAPINSLLQ MAKALIKSPS QDEMLPTYLK 750
    DLSISIDKAE HEISSSPGSL GAIINILDLL STVPTQVNSE MMTHVLSTVN 800
    VILGKPVLNT WKVLQQQWTN QSSQLLHSVE RFSQALQSGD SPPLSFSQTN 850
    VQMSSMVIKS SHPETYQQRF VFPYFDLWGN VVIDKSYLEN LQSDSSIVTM 900
    AFPTLQAILA QDIQENNFAE SLVMTTTVSH NTTMPFRISM TFKNNSPSGG 950
    ETKCVFWNFR LANNTGGWDS SGCYVEEGDG DNVTCICDHL TSFSILMSPD 1000
    SPDPSSLLGI LLDIISYVGV GFSILSLAAC LVVEAVVWKS VTKNRTSYMR 1050
    HTCIVNIAAS LLVANTWFIV VAAIQDNRYI LCKTACVAAT FFIHFFYLSV 1100
    FFWMLTLGLM LFYRLVFILH ETSRSTQKAI AFCLGYGCPL AISVITLGAT 1150
    QPREVYTRKN VCWLNWEDTK ALLAFAIPAL IIVVVNITIT IVVITKILRP 1200
    SIGDKPCKQE KSSLFQISKS IGVLTPLLGL TWGFGLTTVF PGTNLVFHII 1250
    FAILNVFQGL FILLFGCLWD LKVQEALLNK FSLSRWSSQH SKSTSLGSST 1300
    PVFSMSSPIS RRFNNLFGKT GTYNVSTPEA TSSSLENSSS ASSLLN 1346
    Length:1,346
    Mass (Da):149,457
    Last modified:May 5, 2009 - v3
    Checksum:i72A9D02B08218A60
    GO
    Isoform 2 (identifier: Q8IZF2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1273-1292: Missing.
         1322-1346: Missing.

    Show »
    Length:1,301
    Mass (Da):144,601
    Checksum:i9DEB380A0BEDA44B
    GO
    Isoform 3 (identifier: Q8IZF2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         272-414: NESNFFVTPE...KQEGKINIPG → R

    Note: No experimental confirmation available.

    Show »
    Length:1,204
    Mass (Da):133,307
    Checksum:i0106B9A59C2D5B0E
    GO

    Sequence cautioni

    The sequence CAB43394.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAA34478.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti272 – 2721Missing in AAN46672. (PubMed:12435584)Curated
    Sequence conflicti573 – 5731V → I in CAB43394. (PubMed:15489334)Curated
    Sequence conflicti1075 – 10751Q → R in AL832125. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti604 – 6041T → M.4 Publications
    Corresponds to variant rs586024 [ dbSNP | Ensembl ].
    VAR_025326
    Natural varianti801 – 8011V → I.1 Publication
    Corresponds to variant rs9395218 [ dbSNP | Ensembl ].
    VAR_055291
    Natural varianti856 – 8561M → T.2 Publications
    Corresponds to variant rs547499 [ dbSNP | Ensembl ].
    VAR_024477

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei272 – 414143NESNF…INIPG → R in isoform 3. 1 PublicationVSP_039130Add
    BLAST
    Alternative sequencei1273 – 129220Missing in isoform 2. 1 PublicationVSP_010837Add
    BLAST
    Alternative sequencei1322 – 134625Missing in isoform 2. 1 PublicationVSP_010838Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY140958 mRNA. Translation: AAN46672.1.
    AY498875 mRNA. Translation: AAS21061.1.
    AB018301 mRNA. Translation: BAA34478.2. Different initiation.
    AL050295 mRNA. Translation: CAB43394.1. Sequence problems.
    AL832125 mRNA. No translation available.
    AL096772 Genomic DNA. Translation: CAB61578.1.
    BC066121 mRNA. Translation: AAH66121.1.
    AY255552 mRNA. Translation: AAO85064.1.
    CCDSiCCDS4919.1. [Q8IZF2-1]
    PIRiT08685.
    RefSeqiNP_001091988.1. NM_001098518.1. [Q8IZF2-1]
    NP_056049.4. NM_015234.4. [Q8IZF2-1]
    UniGeneiHs.362806.

    Genome annotation databases

    EnsembliENST00000265417; ENSP00000265417; ENSG00000069122. [Q8IZF2-1]
    ENST00000283296; ENSP00000283296; ENSG00000069122. [Q8IZF2-1]
    GeneIDi221395.
    KEGGihsa:221395.
    UCSCiuc003oyo.3. human. [Q8IZF2-1]
    uc003oyp.3. human. [Q8IZF2-3]
    uc010jzi.1. human. [Q8IZF2-2]

    Polymorphism databases

    DMDMi229462973.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY140958 mRNA. Translation: AAN46672.1 .
    AY498875 mRNA. Translation: AAS21061.1 .
    AB018301 mRNA. Translation: BAA34478.2 . Different initiation.
    AL050295 mRNA. Translation: CAB43394.1 . Sequence problems.
    AL832125 mRNA. No translation available.
    AL096772 Genomic DNA. Translation: CAB61578.1 .
    BC066121 mRNA. Translation: AAH66121.1 .
    AY255552 mRNA. Translation: AAO85064.1 .
    CCDSi CCDS4919.1. [Q8IZF2-1 ]
    PIRi T08685.
    RefSeqi NP_001091988.1. NM_001098518.1. [Q8IZF2-1 ]
    NP_056049.4. NM_015234.4. [Q8IZF2-1 ]
    UniGenei Hs.362806.

    3D structure databases

    ProteinModelPortali Q8IZF2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8IZF2. 1 interaction.
    MINTi MINT-4715450.
    STRINGi 9606.ENSP00000265417.

    Protein family/group databases

    MEROPSi S63.022.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8IZF2.

    Polymorphism databases

    DMDMi 229462973.

    Proteomic databases

    PaxDbi Q8IZF2.
    PRIDEi Q8IZF2.

    Protocols and materials databases

    DNASUi 221395.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265417 ; ENSP00000265417 ; ENSG00000069122 . [Q8IZF2-1 ]
    ENST00000283296 ; ENSP00000283296 ; ENSG00000069122 . [Q8IZF2-1 ]
    GeneIDi 221395.
    KEGGi hsa:221395.
    UCSCi uc003oyo.3. human. [Q8IZF2-1 ]
    uc003oyp.3. human. [Q8IZF2-3 ]
    uc010jzi.1. human. [Q8IZF2-2 ]

    Organism-specific databases

    CTDi 221395.
    GeneCardsi GC06M046820.
    HGNCi HGNC:19030. GPR116.
    neXtProti NX_Q8IZF2.
    PharmGKBi PA134886165.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235397.
    HOGENOMi HOG000112764.
    HOVERGENi HBG051772.
    InParanoidi Q8IZF2.
    KOi K08458.
    OMAi STPVFSM.
    PhylomeDBi Q8IZF2.
    TreeFami TF316380.

    Miscellaneous databases

    ChiTaRSi GPR116. human.
    GeneWikii GPR116.
    GenomeRNAii 221395.
    NextBioi 91311.
    PROi Q8IZF2.

    Gene expression databases

    ArrayExpressi Q8IZF2.
    Bgeei Q8IZF2.
    CleanExi HS_GPR116.
    Genevestigatori Q8IZF2.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR017981. GPCR_2-like.
    IPR008078. GPCR_2_Ig-hepta_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR000082. SEA_dom.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    PF07679. I-set. 1 hit.
    PF01390. SEA. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01695. IGHEPTARCPTR.
    SMARTi SM00303. GPS. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00200. SEA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82671. SSF82671. 1 hit.
    PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50835. IG_LIKE. 3 hits.
    PS50024. SEA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
      Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
      FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete coding sequence of GPR116."
      Bonner T.I., Nagle J.W., Kauffman D.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-604.
      Tissue: Brain.
    3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-604 AND THR-856.
      Tissue: Brain.
    4. Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-613 (ISOFORM 1), VARIANTS MET-604 AND ILE-801.
      Tissue: Brain and Cervix.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-604 AND THR-856.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 949-1062.
    9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-256 AND ASN-315.
      Tissue: Plasma.

    Entry informationi

    Entry nameiGP116_HUMAN
    AccessioniPrimary (citable) accession number: Q8IZF2
    Secondary accession number(s): O94858
    , Q5TF06, Q6RGN2, Q86SP0, Q9Y3Z2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3