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Q8IZF2

- GP116_HUMAN

UniProt

Q8IZF2 - GP116_HUMAN

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Protein

Probable G-protein coupled receptor 116

Gene

GPR116

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May have a role in the regulation of acid-base balance.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei226 – 2272CleavageBy similarity
Sitei990 – 9912CleavageBy similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. energy reserve metabolic process Source: Ensembl
  2. fat cell differentiation Source: Ensembl
  3. glucose homeostasis Source: Ensembl
  4. G-protein coupled receptor signaling pathway Source: GDB
  5. neuropeptide signaling pathway Source: InterPro
  6. regulation of lipid metabolic process Source: Ensembl
  7. surfactant homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 116
Gene namesi
Name:GPR116
Synonyms:KIAA0758
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:19030. GPR116.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. cytoplasmic vesicle Source: MGI
  3. integral component of membrane Source: GDB
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 13461325Probable G-protein coupled receptor 116PRO_0000012896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)1 Publication
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi315 – 3151N-linked (GlcNAc...)1 Publication
Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi649 – 6491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi666 – 6661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi820 – 8201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi931 – 9311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi963 – 9631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi982 – 9821N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Proteolytically cleaved into 2 highly conserved sites: one in the SEA domain and the other in the stalk domain region preceding the first transmembrane. The later 2 subunits, the extracellular subunit and the seven-transmembrane subunit, remain tightly associated and non-covalently linked (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IZF2.
PRIDEiQ8IZF2.

PTM databases

PhosphoSiteiQ8IZF2.

Expressioni

Gene expression databases

BgeeiQ8IZF2.
CleanExiHS_GPR116.
ExpressionAtlasiQ8IZF2. baseline and differential.
GenevestigatoriQ8IZF2.

Interactioni

Subunit structurei

Exists as disulfide-linked dimers at the cell surface.By similarity

Protein-protein interaction databases

IntActiQ8IZF2. 1 interaction.
MINTiMINT-4715450.
STRINGi9606.ENSP00000265417.

Structurei

3D structure databases

ProteinModelPortaliQ8IZF2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 1006985ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1028 – 105326CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1075 – 109016ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1112 – 112817CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1150 – 117324ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1195 – 122026CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1242 – 12443ExtracellularSequence Analysis
Topological domaini1266 – 134681CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1007 – 102721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei1054 – 107421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei1091 – 111121Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei1129 – 114921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei1174 – 119421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei1221 – 124121Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei1245 – 126521Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini166 – 273108SEAPROSITE-ProRule annotationAdd
BLAST
Domaini267 – 368102Ig-like 1Add
BLAST
Domaini369 – 46698Ig-like 2Add
BLAST
Domaini471 – 56191Ig-like 3Add
BLAST
Domaini951 – 100252GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235397.
GeneTreeiENSGT00610000085899.
HOGENOMiHOG000112764.
HOVERGENiHBG051772.
InParanoidiQ8IZF2.
KOiK08458.
OMAiSTPVFSM.
PhylomeDBiQ8IZF2.
TreeFamiTF316380.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF07679. I-set. 1 hit.
PF01390. SEA. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTiSM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZF2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSPRRTTLC LMFIVIYSSK AALNWNYEST IHPLSLHEHE PAGEEALRQK
60 70 80 90 100
RAVATKSPTA EEYTVNIEIS FENASFLDPI KAYLNSLSFP IHGNNTDQIT
110 120 130 140 150
DILSINVTTV CRPAGNEIWC SCETGYGWPR ERCLHNLICQ ERDVFLPGHH
160 170 180 190 200
CSCLKELPPN GPFCLLQEDV TLNMRVRLNV GFQEDLMNTS SALYRSYKTD
210 220 230 240 250
LETAFRKGYG ILPGFKGVTV TGFKSGSVVV TYEVKTTPPS LELIHKANEQ
260 270 280 290 300
VVQSLNQTYK MDYNSFQAVT INESNFFVTP EIIFEGDTVS LVCEKEVLSS
310 320 330 340 350
NVSWRYEEQQ LEIQNSSRFS IYTALFNNMT SVSKLTIHNI TPGDAGEYVC
360 370 380 390 400
KLILDIFEYE CKKKIDVMPI QILANEEMKV MCDNNPVSLN CCSQGNVNWS
410 420 430 440 450
KVEWKQEGKI NIPGTPETDI DSSCSRYTLK ADGTQCPSGS SGTTVIYTCE
460 470 480 490 500
FISAYGARGS ANIKVTFISV ANLTITPDPI SVSEGQNFSI KCISDVSNYD
510 520 530 540 550
EVYWNTSAGI KIYQRFYTTR RYLDGAESVL TVKTSTREWN GTYHCIFRYK
560 570 580 590 600
NSYSIATKDV IVHPLPLKLN IMVDPLEATV SCSGSHHIKC CIEEDGDYKV
610 620 630 640 650
TFHTGSSSLP AAKEVNKKQV CYKHNFNASS VSWCSKTVDV CCHFTNAANN
660 670 680 690 700
SVWSPSMKLN LVPGENITCQ DPVIGVGEPG KVIQKLCRFS NVPSSPESPI
710 720 730 740 750
GGTITYKCVG SQWEEKRNDC ISAPINSLLQ MAKALIKSPS QDEMLPTYLK
760 770 780 790 800
DLSISIDKAE HEISSSPGSL GAIINILDLL STVPTQVNSE MMTHVLSTVN
810 820 830 840 850
VILGKPVLNT WKVLQQQWTN QSSQLLHSVE RFSQALQSGD SPPLSFSQTN
860 870 880 890 900
VQMSSMVIKS SHPETYQQRF VFPYFDLWGN VVIDKSYLEN LQSDSSIVTM
910 920 930 940 950
AFPTLQAILA QDIQENNFAE SLVMTTTVSH NTTMPFRISM TFKNNSPSGG
960 970 980 990 1000
ETKCVFWNFR LANNTGGWDS SGCYVEEGDG DNVTCICDHL TSFSILMSPD
1010 1020 1030 1040 1050
SPDPSSLLGI LLDIISYVGV GFSILSLAAC LVVEAVVWKS VTKNRTSYMR
1060 1070 1080 1090 1100
HTCIVNIAAS LLVANTWFIV VAAIQDNRYI LCKTACVAAT FFIHFFYLSV
1110 1120 1130 1140 1150
FFWMLTLGLM LFYRLVFILH ETSRSTQKAI AFCLGYGCPL AISVITLGAT
1160 1170 1180 1190 1200
QPREVYTRKN VCWLNWEDTK ALLAFAIPAL IIVVVNITIT IVVITKILRP
1210 1220 1230 1240 1250
SIGDKPCKQE KSSLFQISKS IGVLTPLLGL TWGFGLTTVF PGTNLVFHII
1260 1270 1280 1290 1300
FAILNVFQGL FILLFGCLWD LKVQEALLNK FSLSRWSSQH SKSTSLGSST
1310 1320 1330 1340
PVFSMSSPIS RRFNNLFGKT GTYNVSTPEA TSSSLENSSS ASSLLN
Length:1,346
Mass (Da):149,457
Last modified:May 5, 2009 - v3
Checksum:i72A9D02B08218A60
GO
Isoform 2 (identifier: Q8IZF2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1292: Missing.
     1322-1346: Missing.

Show »
Length:1,301
Mass (Da):144,601
Checksum:i9DEB380A0BEDA44B
GO
Isoform 3 (identifier: Q8IZF2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-414: NESNFFVTPE...KQEGKINIPG → R

Note: No experimental confirmation available.

Show »
Length:1,204
Mass (Da):133,307
Checksum:i0106B9A59C2D5B0E
GO

Sequence cautioni

The sequence CAB43394.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAA34478.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721Missing in AAN46672. (PubMed:12435584)Curated
Sequence conflicti573 – 5731V → I in CAB43394. (PubMed:15489334)Curated
Sequence conflicti1075 – 10751Q → R in AL832125. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti604 – 6041T → M.4 Publications
Corresponds to variant rs586024 [ dbSNP | Ensembl ].
VAR_025326
Natural varianti801 – 8011V → I.1 Publication
Corresponds to variant rs9395218 [ dbSNP | Ensembl ].
VAR_055291
Natural varianti856 – 8561M → T.2 Publications
Corresponds to variant rs547499 [ dbSNP | Ensembl ].
VAR_024477

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei272 – 414143NESNF…INIPG → R in isoform 3. 1 PublicationVSP_039130Add
BLAST
Alternative sequencei1273 – 129220Missing in isoform 2. 1 PublicationVSP_010837Add
BLAST
Alternative sequencei1322 – 134625Missing in isoform 2. 1 PublicationVSP_010838Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY140958 mRNA. Translation: AAN46672.1.
AY498875 mRNA. Translation: AAS21061.1.
AB018301 mRNA. Translation: BAA34478.2. Different initiation.
AL050295 mRNA. Translation: CAB43394.1. Sequence problems.
AL832125 mRNA. No translation available.
AL096772 Genomic DNA. Translation: CAB61578.1.
BC066121 mRNA. Translation: AAH66121.1.
AY255552 mRNA. Translation: AAO85064.1.
CCDSiCCDS4919.1. [Q8IZF2-1]
PIRiT08685.
RefSeqiNP_001091988.1. NM_001098518.1. [Q8IZF2-1]
NP_056049.4. NM_015234.4. [Q8IZF2-1]
UniGeneiHs.362806.

Genome annotation databases

EnsembliENST00000265417; ENSP00000265417; ENSG00000069122. [Q8IZF2-1]
ENST00000283296; ENSP00000283296; ENSG00000069122. [Q8IZF2-1]
GeneIDi221395.
KEGGihsa:221395.
UCSCiuc003oyo.3. human. [Q8IZF2-1]
uc003oyp.3. human. [Q8IZF2-3]
uc010jzi.1. human. [Q8IZF2-2]

Polymorphism databases

DMDMi229462973.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY140958 mRNA. Translation: AAN46672.1 .
AY498875 mRNA. Translation: AAS21061.1 .
AB018301 mRNA. Translation: BAA34478.2 . Different initiation.
AL050295 mRNA. Translation: CAB43394.1 . Sequence problems.
AL832125 mRNA. No translation available.
AL096772 Genomic DNA. Translation: CAB61578.1 .
BC066121 mRNA. Translation: AAH66121.1 .
AY255552 mRNA. Translation: AAO85064.1 .
CCDSi CCDS4919.1. [Q8IZF2-1 ]
PIRi T08685.
RefSeqi NP_001091988.1. NM_001098518.1. [Q8IZF2-1 ]
NP_056049.4. NM_015234.4. [Q8IZF2-1 ]
UniGenei Hs.362806.

3D structure databases

ProteinModelPortali Q8IZF2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8IZF2. 1 interaction.
MINTi MINT-4715450.
STRINGi 9606.ENSP00000265417.

Protein family/group databases

MEROPSi S63.022.
GPCRDBi Search...

PTM databases

PhosphoSitei Q8IZF2.

Polymorphism databases

DMDMi 229462973.

Proteomic databases

PaxDbi Q8IZF2.
PRIDEi Q8IZF2.

Protocols and materials databases

DNASUi 221395.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265417 ; ENSP00000265417 ; ENSG00000069122 . [Q8IZF2-1 ]
ENST00000283296 ; ENSP00000283296 ; ENSG00000069122 . [Q8IZF2-1 ]
GeneIDi 221395.
KEGGi hsa:221395.
UCSCi uc003oyo.3. human. [Q8IZF2-1 ]
uc003oyp.3. human. [Q8IZF2-3 ]
uc010jzi.1. human. [Q8IZF2-2 ]

Organism-specific databases

CTDi 221395.
GeneCardsi GC06M046820.
HGNCi HGNC:19030. GPR116.
neXtProti NX_Q8IZF2.
PharmGKBi PA134886165.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235397.
GeneTreei ENSGT00610000085899.
HOGENOMi HOG000112764.
HOVERGENi HBG051772.
InParanoidi Q8IZF2.
KOi K08458.
OMAi STPVFSM.
PhylomeDBi Q8IZF2.
TreeFami TF316380.

Miscellaneous databases

ChiTaRSi GPR116. human.
GeneWikii GPR116.
GenomeRNAii 221395.
NextBioi 91311.
PROi Q8IZF2.

Gene expression databases

Bgeei Q8IZF2.
CleanExi HS_GPR116.
ExpressionAtlasi Q8IZF2. baseline and differential.
Genevestigatori Q8IZF2.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000082. SEA_dom.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF07679. I-set. 1 hit.
PF01390. SEA. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTi SM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00200. SEA. 1 hit.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 1 hit.
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS50024. SEA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
    Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
    FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete coding sequence of GPR116."
    Bonner T.I., Nagle J.W., Kauffman D.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-604.
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-604 AND THR-856.
    Tissue: Brain.
  4. Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-613 (ISOFORM 1), VARIANTS MET-604 AND ILE-801.
    Tissue: Brain and Cervix.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-604 AND THR-856.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 949-1062.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-256 AND ASN-315.
    Tissue: Plasma.

Entry informationi

Entry nameiGP116_HUMAN
AccessioniPrimary (citable) accession number: Q8IZF2
Secondary accession number(s): O94858
, Q5TF06, Q6RGN2, Q86SP0, Q9Y3Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3