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Q8IZF2

- GP116_HUMAN

UniProt

Q8IZF2 - GP116_HUMAN

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Protein
Probable G-protein coupled receptor 116
Gene
GPR116, KIAA0758
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May have a role in the regulation of acid-base balance By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei226 – 2272Cleavage By similarity
Sitei990 – 9912Cleavage By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. energy reserve metabolic process Source: Ensembl
  3. fat cell differentiation Source: Ensembl
  4. glucose homeostasis Source: Ensembl
  5. neuropeptide signaling pathway Source: InterPro
  6. regulation of lipid metabolic process Source: Ensembl
  7. surfactant homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 116
Gene namesi
Name:GPR116
Synonyms:KIAA0758
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:19030. GPR116.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 1006985Extracellular Reviewed prediction
Add
BLAST
Transmembranei1007 – 102721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini1028 – 105326Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1054 – 107421Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini1075 – 109016Extracellular Reviewed prediction
Add
BLAST
Transmembranei1091 – 111121Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini1112 – 112817Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1129 – 114921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini1150 – 117324Extracellular Reviewed prediction
Add
BLAST
Transmembranei1174 – 119421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini1195 – 122026Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1221 – 124121Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini1242 – 12443Extracellular Reviewed prediction
Transmembranei1245 – 126521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini1266 – 134681Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. cytoplasmic vesicle Source: MGI
  3. integral component of membrane Source: GDB
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 13461325Probable G-protein coupled receptor 116
PRO_0000012896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi256 – 2561N-linked (GlcNAc...)1 Publication
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi315 – 3151N-linked (GlcNAc...)1 Publication
Glycosylationi328 – 3281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi398 – 3981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi472 – 4721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi487 – 4871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi505 – 5051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi540 – 5401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi627 – 6271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi649 – 6491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi666 – 6661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi820 – 8201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi931 – 9311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi963 – 9631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi982 – 9821N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Proteolytically cleaved into 2 highly conserved sites: one in the SEA domain and the other in the stalk domain region preceding the first transmembrane. The later 2 subunits, the extracellular subunit and the seven-transmembrane subunit, remain tightly associated and non-covalently linked By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IZF2.
PRIDEiQ8IZF2.

PTM databases

PhosphoSiteiQ8IZF2.

Expressioni

Gene expression databases

ArrayExpressiQ8IZF2.
BgeeiQ8IZF2.
CleanExiHS_GPR116.
GenevestigatoriQ8IZF2.

Interactioni

Subunit structurei

Exists as disulfide-linked dimers at the cell surface By similarity.

Protein-protein interaction databases

IntActiQ8IZF2. 1 interaction.
MINTiMINT-4715450.
STRINGi9606.ENSP00000265417.

Structurei

3D structure databases

ProteinModelPortaliQ8IZF2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini166 – 273108SEA
Add
BLAST
Domaini267 – 368102Ig-like 1
Add
BLAST
Domaini369 – 46698Ig-like 2
Add
BLAST
Domaini471 – 56191Ig-like 3
Add
BLAST
Domaini951 – 100252GPS
Add
BLAST

Sequence similaritiesi

Contains 1 GPS domain.
Contains 1 SEA domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235397.
HOGENOMiHOG000112764.
HOVERGENiHBG051772.
InParanoidiQ8IZF2.
KOiK08458.
OMAiSTPVFSM.
PhylomeDBiQ8IZF2.
TreeFamiTF316380.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000082. SEA_dom.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF07679. I-set. 1 hit.
PF01390. SEA. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTiSM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00200. SEA. 1 hit.
[Graphical view]
SUPFAMiSSF82671. SSF82671. 1 hit.
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS50024. SEA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IZF2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSPRRTTLC LMFIVIYSSK AALNWNYEST IHPLSLHEHE PAGEEALRQK     50
RAVATKSPTA EEYTVNIEIS FENASFLDPI KAYLNSLSFP IHGNNTDQIT 100
DILSINVTTV CRPAGNEIWC SCETGYGWPR ERCLHNLICQ ERDVFLPGHH 150
CSCLKELPPN GPFCLLQEDV TLNMRVRLNV GFQEDLMNTS SALYRSYKTD 200
LETAFRKGYG ILPGFKGVTV TGFKSGSVVV TYEVKTTPPS LELIHKANEQ 250
VVQSLNQTYK MDYNSFQAVT INESNFFVTP EIIFEGDTVS LVCEKEVLSS 300
NVSWRYEEQQ LEIQNSSRFS IYTALFNNMT SVSKLTIHNI TPGDAGEYVC 350
KLILDIFEYE CKKKIDVMPI QILANEEMKV MCDNNPVSLN CCSQGNVNWS 400
KVEWKQEGKI NIPGTPETDI DSSCSRYTLK ADGTQCPSGS SGTTVIYTCE 450
FISAYGARGS ANIKVTFISV ANLTITPDPI SVSEGQNFSI KCISDVSNYD 500
EVYWNTSAGI KIYQRFYTTR RYLDGAESVL TVKTSTREWN GTYHCIFRYK 550
NSYSIATKDV IVHPLPLKLN IMVDPLEATV SCSGSHHIKC CIEEDGDYKV 600
TFHTGSSSLP AAKEVNKKQV CYKHNFNASS VSWCSKTVDV CCHFTNAANN 650
SVWSPSMKLN LVPGENITCQ DPVIGVGEPG KVIQKLCRFS NVPSSPESPI 700
GGTITYKCVG SQWEEKRNDC ISAPINSLLQ MAKALIKSPS QDEMLPTYLK 750
DLSISIDKAE HEISSSPGSL GAIINILDLL STVPTQVNSE MMTHVLSTVN 800
VILGKPVLNT WKVLQQQWTN QSSQLLHSVE RFSQALQSGD SPPLSFSQTN 850
VQMSSMVIKS SHPETYQQRF VFPYFDLWGN VVIDKSYLEN LQSDSSIVTM 900
AFPTLQAILA QDIQENNFAE SLVMTTTVSH NTTMPFRISM TFKNNSPSGG 950
ETKCVFWNFR LANNTGGWDS SGCYVEEGDG DNVTCICDHL TSFSILMSPD 1000
SPDPSSLLGI LLDIISYVGV GFSILSLAAC LVVEAVVWKS VTKNRTSYMR 1050
HTCIVNIAAS LLVANTWFIV VAAIQDNRYI LCKTACVAAT FFIHFFYLSV 1100
FFWMLTLGLM LFYRLVFILH ETSRSTQKAI AFCLGYGCPL AISVITLGAT 1150
QPREVYTRKN VCWLNWEDTK ALLAFAIPAL IIVVVNITIT IVVITKILRP 1200
SIGDKPCKQE KSSLFQISKS IGVLTPLLGL TWGFGLTTVF PGTNLVFHII 1250
FAILNVFQGL FILLFGCLWD LKVQEALLNK FSLSRWSSQH SKSTSLGSST 1300
PVFSMSSPIS RRFNNLFGKT GTYNVSTPEA TSSSLENSSS ASSLLN 1346
Length:1,346
Mass (Da):149,457
Last modified:May 5, 2009 - v3
Checksum:i72A9D02B08218A60
GO
Isoform 2 (identifier: Q8IZF2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1292: Missing.
     1322-1346: Missing.

Show »
Length:1,301
Mass (Da):144,601
Checksum:i9DEB380A0BEDA44B
GO
Isoform 3 (identifier: Q8IZF2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-414: NESNFFVTPE...KQEGKINIPG → R

Note: No experimental confirmation available.

Show »
Length:1,204
Mass (Da):133,307
Checksum:i0106B9A59C2D5B0E
GO

Sequence cautioni

The sequence CAB43394.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAA34478.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti604 – 6041T → M.4 Publications
Corresponds to variant rs586024 [ dbSNP | Ensembl ].
VAR_025326
Natural varianti801 – 8011V → I.1 Publication
Corresponds to variant rs9395218 [ dbSNP | Ensembl ].
VAR_055291
Natural varianti856 – 8561M → T.2 Publications
Corresponds to variant rs547499 [ dbSNP | Ensembl ].
VAR_024477

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei272 – 414143NESNF…INIPG → R in isoform 3.
VSP_039130Add
BLAST
Alternative sequencei1273 – 129220Missing in isoform 2.
VSP_010837Add
BLAST
Alternative sequencei1322 – 134625Missing in isoform 2.
VSP_010838Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721Missing in AAN46672. 1 Publication
Sequence conflicti573 – 5731V → I in CAB43394. 1 Publication
Sequence conflicti1075 – 10751Q → R in AL832125. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY140958 mRNA. Translation: AAN46672.1.
AY498875 mRNA. Translation: AAS21061.1.
AB018301 mRNA. Translation: BAA34478.2. Different initiation.
AL050295 mRNA. Translation: CAB43394.1. Sequence problems.
AL832125 mRNA. No translation available.
AL096772 Genomic DNA. Translation: CAB61578.1.
BC066121 mRNA. Translation: AAH66121.1.
AY255552 mRNA. Translation: AAO85064.1.
CCDSiCCDS4919.1. [Q8IZF2-1]
PIRiT08685.
RefSeqiNP_001091988.1. NM_001098518.1. [Q8IZF2-1]
NP_056049.4. NM_015234.4. [Q8IZF2-1]
UniGeneiHs.362806.

Genome annotation databases

EnsembliENST00000265417; ENSP00000265417; ENSG00000069122. [Q8IZF2-1]
ENST00000283296; ENSP00000283296; ENSG00000069122. [Q8IZF2-1]
ENST00000456426; ENSP00000412866; ENSG00000069122. [Q8IZF2-3]
GeneIDi221395.
KEGGihsa:221395.
UCSCiuc003oyo.3. human. [Q8IZF2-1]
uc003oyp.3. human. [Q8IZF2-3]
uc010jzi.1. human. [Q8IZF2-2]

Polymorphism databases

DMDMi229462973.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY140958 mRNA. Translation: AAN46672.1 .
AY498875 mRNA. Translation: AAS21061.1 .
AB018301 mRNA. Translation: BAA34478.2 . Different initiation.
AL050295 mRNA. Translation: CAB43394.1 . Sequence problems.
AL832125 mRNA. No translation available.
AL096772 Genomic DNA. Translation: CAB61578.1 .
BC066121 mRNA. Translation: AAH66121.1 .
AY255552 mRNA. Translation: AAO85064.1 .
CCDSi CCDS4919.1. [Q8IZF2-1 ]
PIRi T08685.
RefSeqi NP_001091988.1. NM_001098518.1. [Q8IZF2-1 ]
NP_056049.4. NM_015234.4. [Q8IZF2-1 ]
UniGenei Hs.362806.

3D structure databases

ProteinModelPortali Q8IZF2.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8IZF2. 1 interaction.
MINTi MINT-4715450.
STRINGi 9606.ENSP00000265417.

Protein family/group databases

MEROPSi S63.022.
GPCRDBi Search...

PTM databases

PhosphoSitei Q8IZF2.

Polymorphism databases

DMDMi 229462973.

Proteomic databases

PaxDbi Q8IZF2.
PRIDEi Q8IZF2.

Protocols and materials databases

DNASUi 221395.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265417 ; ENSP00000265417 ; ENSG00000069122 . [Q8IZF2-1 ]
ENST00000283296 ; ENSP00000283296 ; ENSG00000069122 . [Q8IZF2-1 ]
ENST00000456426 ; ENSP00000412866 ; ENSG00000069122 . [Q8IZF2-3 ]
GeneIDi 221395.
KEGGi hsa:221395.
UCSCi uc003oyo.3. human. [Q8IZF2-1 ]
uc003oyp.3. human. [Q8IZF2-3 ]
uc010jzi.1. human. [Q8IZF2-2 ]

Organism-specific databases

CTDi 221395.
GeneCardsi GC06M046820.
HGNCi HGNC:19030. GPR116.
neXtProti NX_Q8IZF2.
PharmGKBi PA134886165.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235397.
HOGENOMi HOG000112764.
HOVERGENi HBG051772.
InParanoidi Q8IZF2.
KOi K08458.
OMAi STPVFSM.
PhylomeDBi Q8IZF2.
TreeFami TF316380.

Miscellaneous databases

ChiTaRSi GPR116. human.
GeneWikii GPR116.
GenomeRNAii 221395.
NextBioi 91311.
PROi Q8IZF2.

Gene expression databases

ArrayExpressi Q8IZF2.
Bgeei Q8IZF2.
CleanExi HS_GPR116.
Genevestigatori Q8IZF2.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR017981. GPCR_2-like.
IPR008078. GPCR_2_Ig-hepta_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000082. SEA_dom.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
PF07679. I-set. 1 hit.
PF01390. SEA. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01695. IGHEPTARCPTR.
SMARTi SM00303. GPS. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00200. SEA. 1 hit.
[Graphical view ]
SUPFAMi SSF82671. SSF82671. 1 hit.
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS50024. SEA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions."
    Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.
    FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete coding sequence of GPR116."
    Bonner T.I., Nagle J.W., Kauffman D.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-604.
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-604 AND THR-856.
    Tissue: Brain.
  4. Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-613 (ISOFORM 1), VARIANTS MET-604 AND ILE-801.
    Tissue: Brain and Cervix.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-604 AND THR-856.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 949-1062.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-256 AND ASN-315.
    Tissue: Plasma.

Entry informationi

Entry nameiGP116_HUMAN
AccessioniPrimary (citable) accession number: Q8IZF2
Secondary accession number(s): O94858
, Q5TF06, Q6RGN2, Q86SP0, Q9Y3Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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