Q8IZF2 (GP116_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 116

Gene names

Name:	GPR116
Synonyms:	KIAA0758

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have a role in the regulation of acid-base balance By similarity.
Subunit structure	Exists as disulfide-linked dimers at the cell surface By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Post-translational modification	Proteolytically cleaved into 2 highly conserved sites: one in the SEA domain and the other in the stalk domain region preceding the first transmembrane. The later 2 subunits, the extracellular subunit and the seven-transmembrane subunit, remain tightly associated and non-covalently linked By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 3 Ig-like (immunoglobulin-like) domains. Contains 1 SEA domain.
Sequence caution	The sequence BAA34478.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAB43394.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement PubMed 15203201. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15203201. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZF2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZF2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1292: Missing.
     1322-1346: Missing.

Isoform 3 (identifier: Q8IZF2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     272-414: NESNFFVTPE...KQEGKINIPG → R

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 1346	1325	Probable G-protein coupled receptor 116		PRO_0000012896
Regions
	Topological domain	22 – 1006	985	Extracellular Potential
	Transmembrane	1007 – 1027	21	Helical; Name=1; Potential
	Topological domain	1028 – 1053	26	Cytoplasmic Potential
	Transmembrane	1054 – 1074	21	Helical; Name=2; Potential
	Topological domain	1075 – 1090	16	Extracellular Potential
	Transmembrane	1091 – 1111	21	Helical; Name=3; Potential
	Topological domain	1112 – 1128	17	Cytoplasmic Potential
	Transmembrane	1129 – 1149	21	Helical; Name=4; Potential
	Topological domain	1150 – 1173	24	Extracellular Potential
	Transmembrane	1174 – 1194	21	Helical; Name=5; Potential
	Topological domain	1195 – 1220	26	Cytoplasmic Potential
	Transmembrane	1221 – 1241	21	Helical; Name=6; Potential
	Topological domain	1242 – 1244	3	Extracellular Potential
	Transmembrane	1245 – 1265	21	Helical; Name=7; Potential
	Topological domain	1266 – 1346	81	Cytoplasmic Potential
	Domain	163 – 281	119	SEA
	Domain	267 – 368	102	Ig-like 1
	Domain	369 – 466	98	Ig-like 2
	Domain	471 – 561	91	Ig-like 3
	Domain	951 – 1002	52	GPS
Sites
	Site	226 – 227	2	Cleavage By similarity
	Site	990 – 991	2	Cleavage By similarity
Amino acid modifications
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	188	1	N-linked (GlcNAc...) Potential
	Glycosylation	256	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	272	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	315	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	328	1	N-linked (GlcNAc...) Potential
	Glycosylation	398	1	N-linked (GlcNAc...) Potential
	Glycosylation	472	1	N-linked (GlcNAc...) Potential
	Glycosylation	487	1	N-linked (GlcNAc...) Potential
	Glycosylation	505	1	N-linked (GlcNAc...) Potential
	Glycosylation	540	1	N-linked (GlcNAc...) Potential
	Glycosylation	627	1	N-linked (GlcNAc...) Potential
	Glycosylation	649	1	N-linked (GlcNAc...) Potential
	Glycosylation	666	1	N-linked (GlcNAc...) Potential
	Glycosylation	820	1	N-linked (GlcNAc...) Potential
	Glycosylation	931	1	N-linked (GlcNAc...) Potential
	Glycosylation	963	1	N-linked (GlcNAc...) Potential
	Glycosylation	982	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	272 – 414	143	NESNF…INIPG → R in isoform 3.		VSP_039130
	Alternative sequence	1273 – 1292	20	Missing in isoform 2.		VSP_010837
	Alternative sequence	1322 – 1346	25	Missing in isoform 2.		VSP_010838
	Natural variant	604	1	T → M. Ref.2 Ref.3 Ref.5 Ref.7 Corresponds to variant rs586024 [ dbSNP | Ensembl ].		VAR_025326
	Natural variant	801	1	V → I. Ref.5 Corresponds to variant rs9395218 [ dbSNP | Ensembl ].		VAR_055291
	Natural variant	856	1	M → T. Ref.3 Ref.7 Corresponds to variant rs547499 [ dbSNP | Ensembl ].		VAR_024477
Experimental info
	Sequence conflict	272	1	Missing in AAN46672. Ref.1
	Sequence conflict	573	1	V → I in CAB43394. Ref.7
	Sequence conflict	1075	1	Q → R in AL832125. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: 72A9D02B08218A60	FASTA	1,346	149,457
	10 20 30 40 50 60 MKSPRRTTLC LMFIVIYSSK AALNWNYEST IHPLSLHEHE PAGEEALRQK RAVATKSPTA 70 80 90 100 110 120 EEYTVNIEIS FENASFLDPI KAYLNSLSFP IHGNNTDQIT DILSINVTTV CRPAGNEIWC 130 140 150 160 170 180 SCETGYGWPR ERCLHNLICQ ERDVFLPGHH CSCLKELPPN GPFCLLQEDV TLNMRVRLNV 190 200 210 220 230 240 GFQEDLMNTS SALYRSYKTD LETAFRKGYG ILPGFKGVTV TGFKSGSVVV TYEVKTTPPS 250 260 270 280 290 300 LELIHKANEQ VVQSLNQTYK MDYNSFQAVT INESNFFVTP EIIFEGDTVS LVCEKEVLSS 310 320 330 340 350 360 NVSWRYEEQQ LEIQNSSRFS IYTALFNNMT SVSKLTIHNI TPGDAGEYVC KLILDIFEYE 370 380 390 400 410 420 CKKKIDVMPI QILANEEMKV MCDNNPVSLN CCSQGNVNWS KVEWKQEGKI NIPGTPETDI 430 440 450 460 470 480 DSSCSRYTLK ADGTQCPSGS SGTTVIYTCE FISAYGARGS ANIKVTFISV ANLTITPDPI 490 500 510 520 530 540 SVSEGQNFSI KCISDVSNYD EVYWNTSAGI KIYQRFYTTR RYLDGAESVL TVKTSTREWN 550 560 570 580 590 600 GTYHCIFRYK NSYSIATKDV IVHPLPLKLN IMVDPLEATV SCSGSHHIKC CIEEDGDYKV 610 620 630 640 650 660 TFHTGSSSLP AAKEVNKKQV CYKHNFNASS VSWCSKTVDV CCHFTNAANN SVWSPSMKLN 670 680 690 700 710 720 LVPGENITCQ DPVIGVGEPG KVIQKLCRFS NVPSSPESPI GGTITYKCVG SQWEEKRNDC 730 740 750 760 770 780 ISAPINSLLQ MAKALIKSPS QDEMLPTYLK DLSISIDKAE HEISSSPGSL GAIINILDLL 790 800 810 820 830 840 STVPTQVNSE MMTHVLSTVN VILGKPVLNT WKVLQQQWTN QSSQLLHSVE RFSQALQSGD 850 860 870 880 890 900 SPPLSFSQTN VQMSSMVIKS SHPETYQQRF VFPYFDLWGN VVIDKSYLEN LQSDSSIVTM 910 920 930 940 950 960 AFPTLQAILA QDIQENNFAE SLVMTTTVSH NTTMPFRISM TFKNNSPSGG ETKCVFWNFR 970 980 990 1000 1010 1020 LANNTGGWDS SGCYVEEGDG DNVTCICDHL TSFSILMSPD SPDPSSLLGI LLDIISYVGV 1030 1040 1050 1060 1070 1080 GFSILSLAAC LVVEAVVWKS VTKNRTSYMR HTCIVNIAAS LLVANTWFIV VAAIQDNRYI 1090 1100 1110 1120 1130 1140 LCKTACVAAT FFIHFFYLSV FFWMLTLGLM LFYRLVFILH ETSRSTQKAI AFCLGYGCPL 1150 1160 1170 1180 1190 1200 AISVITLGAT QPREVYTRKN VCWLNWEDTK ALLAFAIPAL IIVVVNITIT IVVITKILRP 1210 1220 1230 1240 1250 1260 SIGDKPCKQE KSSLFQISKS IGVLTPLLGL TWGFGLTTVF PGTNLVFHII FAILNVFQGL 1270 1280 1290 1300 1310 1320 FILLFGCLWD LKVQEALLNK FSLSRWSSQH SKSTSLGSST PVFSMSSPIS RRFNNLFGKT 1330 1340 GTYNVSTPEA TSSSLENSSS ASSLLN
	Isoform 2 [UniParc]. Checksum: 9DEB380A0BEDA44B	FASTA	1,301	144,601
	10 20 30 40 50 60 MKSPRRTTLC LMFIVIYSSK AALNWNYEST IHPLSLHEHE PAGEEALRQK RAVATKSPTA 70 80 90 100 110 120 EEYTVNIEIS FENASFLDPI KAYLNSLSFP IHGNNTDQIT DILSINVTTV CRPAGNEIWC 130 140 150 160 170 180 SCETGYGWPR ERCLHNLICQ ERDVFLPGHH CSCLKELPPN GPFCLLQEDV TLNMRVRLNV 190 200 210 220 230 240 GFQEDLMNTS SALYRSYKTD LETAFRKGYG ILPGFKGVTV TGFKSGSVVV TYEVKTTPPS 250 260 270 280 290 300 LELIHKANEQ VVQSLNQTYK MDYNSFQAVT INESNFFVTP EIIFEGDTVS LVCEKEVLSS 310 320 330 340 350 360 NVSWRYEEQQ LEIQNSSRFS IYTALFNNMT SVSKLTIHNI TPGDAGEYVC KLILDIFEYE 370 380 390 400 410 420 CKKKIDVMPI QILANEEMKV MCDNNPVSLN CCSQGNVNWS KVEWKQEGKI NIPGTPETDI 430 440 450 460 470 480 DSSCSRYTLK ADGTQCPSGS SGTTVIYTCE FISAYGARGS ANIKVTFISV ANLTITPDPI 490 500 510 520 530 540 SVSEGQNFSI KCISDVSNYD EVYWNTSAGI KIYQRFYTTR RYLDGAESVL TVKTSTREWN 550 560 570 580 590 600 GTYHCIFRYK NSYSIATKDV IVHPLPLKLN IMVDPLEATV SCSGSHHIKC CIEEDGDYKV 610 620 630 640 650 660 TFHTGSSSLP AAKEVNKKQV CYKHNFNASS VSWCSKTVDV CCHFTNAANN SVWSPSMKLN 670 680 690 700 710 720 LVPGENITCQ DPVIGVGEPG KVIQKLCRFS NVPSSPESPI GGTITYKCVG SQWEEKRNDC 730 740 750 760 770 780 ISAPINSLLQ MAKALIKSPS QDEMLPTYLK DLSISIDKAE HEISSSPGSL GAIINILDLL 790 800 810 820 830 840 STVPTQVNSE MMTHVLSTVN VILGKPVLNT WKVLQQQWTN QSSQLLHSVE RFSQALQSGD 850 860 870 880 890 900 SPPLSFSQTN VQMSSMVIKS SHPETYQQRF VFPYFDLWGN VVIDKSYLEN LQSDSSIVTM 910 920 930 940 950 960 AFPTLQAILA QDIQENNFAE SLVMTTTVSH NTTMPFRISM TFKNNSPSGG ETKCVFWNFR 970 980 990 1000 1010 1020 LANNTGGWDS SGCYVEEGDG DNVTCICDHL TSFSILMSPD SPDPSSLLGI LLDIISYVGV 1030 1040 1050 1060 1070 1080 GFSILSLAAC LVVEAVVWKS VTKNRTSYMR HTCIVNIAAS LLVANTWFIV VAAIQDNRYI 1090 1100 1110 1120 1130 1140 LCKTACVAAT FFIHFFYLSV FFWMLTLGLM LFYRLVFILH ETSRSTQKAI AFCLGYGCPL 1150 1160 1170 1180 1190 1200 AISVITLGAT QPREVYTRKN VCWLNWEDTK ALLAFAIPAL IIVVVNITIT IVVITKILRP 1210 1220 1230 1240 1250 1260 SIGDKPCKQE KSSLFQISKS IGVLTPLLGL TWGFGLTTVF PGTNLVFHII FAILNVFQGL 1270 1280 1290 1300 FILLFGCLWD LKSTSLGSST PVFSMSSPIS RRFNNLFGKT G
	Isoform 3 [UniParc]. Checksum: 0106B9A59C2D5B0E	FASTA	1,204	133,307
	10 20 30 40 50 60 MKSPRRTTLC LMFIVIYSSK AALNWNYEST IHPLSLHEHE PAGEEALRQK RAVATKSPTA 70 80 90 100 110 120 EEYTVNIEIS FENASFLDPI KAYLNSLSFP IHGNNTDQIT DILSINVTTV CRPAGNEIWC 130 140 150 160 170 180 SCETGYGWPR ERCLHNLICQ ERDVFLPGHH CSCLKELPPN GPFCLLQEDV TLNMRVRLNV 190 200 210 220 230 240 GFQEDLMNTS SALYRSYKTD LETAFRKGYG ILPGFKGVTV TGFKSGSVVV TYEVKTTPPS 250 260 270 280 290 300 LELIHKANEQ VVQSLNQTYK MDYNSFQAVT IRTPETDIDS SCSRYTLKAD GTQCPSGSSG 310 320 330 340 350 360 TTVIYTCEFI SAYGARGSAN IKVTFISVAN LTITPDPISV SEGQNFSIKC ISDVSNYDEV 370 380 390 400 410 420 YWNTSAGIKI YQRFYTTRRY LDGAESVLTV KTSTREWNGT YHCIFRYKNS YSIATKDVIV 430 440 450 460 470 480 HPLPLKLNIM VDPLEATVSC SGSHHIKCCI EEDGDYKVTF HTGSSSLPAA KEVNKKQVCY 490 500 510 520 530 540 KHNFNASSVS WCSKTVDVCC HFTNAANNSV WSPSMKLNLV PGENITCQDP VIGVGEPGKV 550 560 570 580 590 600 IQKLCRFSNV PSSPESPIGG TITYKCVGSQ WEEKRNDCIS APINSLLQMA KALIKSPSQD 610 620 630 640 650 660 EMLPTYLKDL SISIDKAEHE ISSSPGSLGA IINILDLLST VPTQVNSEMM THVLSTVNVI 670 680 690 700 710 720 LGKPVLNTWK VLQQQWTNQS SQLLHSVERF SQALQSGDSP PLSFSQTNVQ MSSMVIKSSH 730 740 750 760 770 780 PETYQQRFVF PYFDLWGNVV IDKSYLENLQ SDSSIVTMAF PTLQAILAQD IQENNFAESL 790 800 810 820 830 840 VMTTTVSHNT TMPFRISMTF KNNSPSGGET KCVFWNFRLA NNTGGWDSSG CYVEEGDGDN 850 860 870 880 890 900 VTCICDHLTS FSILMSPDSP DPSSLLGILL DIISYVGVGF SILSLAACLV VEAVVWKSVT 910 920 930 940 950 960 KNRTSYMRHT CIVNIAASLL VANTWFIVVA AIQDNRYILC KTACVAATFF IHFFYLSVFF 970 980 990 1000 1010 1020 WMLTLGLMLF YRLVFILHET SRSTQKAIAF CLGYGCPLAI SVITLGATQP REVYTRKNVC 1030 1040 1050 1060 1070 1080 WLNWEDTKAL LAFAIPALII VVVNITITIV VITKILRPSI GDKPCKQEKS SLFQISKSIG 1090 1100 1110 1120 1130 1140 VLTPLLGLTW GFGLTTVFPG TNLVFHIIFA ILNVFQGLFI LLFGCLWDLK VQEALLNKFS 1150 1160 1170 1180 1190 1200 LSRWSSQHSK STSLGSSTPV FSMSSPISRR FNNLFGKTGT YNVSTPEATS SSLENSSSAS SLLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions." Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B. FEBS Lett. 531:407-414(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Complete coding sequence of GPR116." Bonner T.I., Nagle J.W., Kauffman D. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-604. Tissue: Brain.
[3]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-604 AND THR-856. Tissue: Brain.
[4]	Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-613 (ISOFORM 1), VARIANTS MET-604 AND ILE-801. Tissue: Brain and Cervix.
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-604 AND THR-856.
[8]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 949-1062.
[9]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-256 AND ASN-315, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY140958 mRNA. Translation: AAN46672.1. AY498875 mRNA. Translation: AAS21061.1. AB018301 mRNA. Translation: BAA34478.2. Different initiation. AL050295 mRNA. Translation: CAB43394.1. Sequence problems. AL832125 mRNA. No translation available. AL096772 Genomic DNA. Translation: CAB61578.1. BC066121 mRNA. Translation: AAH66121.1. AY255552 mRNA. Translation: AAO85064.1.
IPI	IPI00437186. IPI00513936. IPI00967115.
PIR	T08685.
RefSeq	NP_001091988.1. NM_001098518.1. NP_056049.4. NM_015234.4.
UniGene	Hs.362806.
3D structure databases
ProteinModelPortal	Q8IZF2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000265417.
Protein family/group databases
MEROPS	S63.022.
GPCRDB	Search...
PTM databases
PhosphoSite	Q8IZF2.
Polymorphism databases
DMDM	229462973.
Proteomic databases
PaxDb	Q8IZF2.
PRIDE	Q8IZF2.
Protocols and materials databases
DNASU	221395.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265417; ENSP00000265417; ENSG00000069122. ENST00000283296; ENSP00000283296; ENSG00000069122. ENST00000452370; ENSP00000394590; ENSG00000069122. ENST00000456426; ENSP00000412866; ENSG00000069122.
GeneID	221395.
KEGG	hsa:221395.
UCSC	uc003oyo.3. human. uc003oyp.3. human. uc010jzi.1. human.
Organism-specific databases
CTD	221395.
GeneCards	GC06M046820.
HGNC	HGNC:19030. GPR116.
neXtProt	NX_Q8IZF2.
PharmGKB	PA134886165.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG235397.
HOGENOM	HOG000112764.
HOVERGEN	HBG051772.
InParanoid	Q8IZF2.
KO	K08458.
OMA	STPVFSM.
OrthoDB	EOG49W2F5.
PhylomeDB	Q8IZF2.
Gene expression databases
ArrayExpress	Q8IZF2.
Bgee	Q8IZF2.
CleanEx	HS_GPR116.
Genevestigator	Q8IZF2.
GermOnline	ENSG00000069122. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR017981. GPCR_2-like. IPR008078. GPCR_2_Ig-hepta_rcpt. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR000203. GPS_dom. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR000082. SEA. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF01825. GPS. 1 hit. PF07679. I-set. 1 hit. PF01390. SEA. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN. PR01695. IGHEPTARCPTR.
SMART	SM00303. GPS. 1 hit. SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. SM00200. SEA. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS50835. IG_LIKE. 3 hits. PS50024. SEA. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GPR116. human.
GenomeRNAi	221395.
NextBio	91311.

Entry information

Entry name

GP116_HUMAN

Accession

Primary (citable) accession number: Q8IZF2
Secondary accession number(s): O94858 , Q5TF06, Q6RGN2, Q86SP0, Q9Y3Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.