Q8IZF0 (NALCN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium leak channel non-selective protein

Alternative name(s):
CanIon
Voltage gated channel-like protein 1

Gene names

Name:	NALCN
Synonyms:	VGCNL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1738 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival By similarity. Ref.7
Subunit structure	Interacts with UNC79 and UNC80 By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the cation-nonselective channel family.
Sequence caution	The sequence BAD18738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat Transmembrane Transmembrane helix
Ligand	Sodium
Molecular function	Ion channel Sodium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sodium ion transmembrane transport Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	sodium channel activity Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IZF0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IZF0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     589-668: ILLSLFVAVI...RESFMKQFID → PPSLIRDLCG...GSLSLSHNLQ
     669-1738: Missing.

Isoform 3 (identifier: Q8IZF0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     216-218: NVT → LSL
     219-1738: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1738	1738	Sodium leak channel non-selective protein		PRO_0000314010
Regions
	Topological domain	1 – 40	40	Cytoplasmic Potential
	Transmembrane	41 – 61	21	Helical; Name=S1 of repeat I; Potential
	Topological domain	62 – 66	5	Extracellular Potential
	Transmembrane	67 – 87	21	Helical; Name=S2 of repeat I; Potential
	Topological domain	88 – 106	19	Cytoplasmic Potential
	Transmembrane	107 – 127	21	Helical; Name=S3 of repeat I; Potential
	Topological domain	128 – 138	11	Extracellular Potential
	Transmembrane	139 – 158	20	Helical; Voltage-sensor; Name=S4 of repeat I; Potential
	Topological domain	159 – 182	24	Cytoplasmic Potential
	Transmembrane	183 – 203	21	Helical; Name=S5 of repeat I; Potential
	Topological domain	204 – 301	98	Extracellular Potential
	Transmembrane	302 – 322	21	Helical; Name=S6 of repeat I; Potential
	Topological domain	323 – 382	60	Cytoplasmic Potential
	Transmembrane	383 – 403	21	Helical; Name=S1 of repeat II; Potential
	Topological domain	404 – 422	19	Extracellular Potential
	Transmembrane	423 – 443	21	Helical; Name=S2 of repeat II; Potential
	Topological domain	444 – 448	5	Cytoplasmic Potential
	Transmembrane	449 – 468	20	Helical; Name=S3 of repeat II; Potential
	Topological domain	469 – 476	8	Extracellular Potential
	Transmembrane	477 – 500	24	Helical; Voltage-sensor; Name=S4 of repeat II; Potential
	Topological domain	501 – 509	9	Cytoplasmic Potential
	Transmembrane	510 – 530	21	Helical; Name=S5 of repeat II; Potential
	Topological domain	531 – 578	48	Extracellular Potential
	Transmembrane	579 – 599	21	Helical; Name=S6 of repeat II; Potential
	Topological domain	600 – 880	281	Cytoplasmic Potential
	Transmembrane	881 – 901	21	Helical; Name=S1 of repeat III; Potential
	Topological domain	902 – 923	22	Extracellular Potential
	Transmembrane	924 – 944	21	Helical; Name=S2 of repeat III; Potential
	Topological domain	945 – 952	8	Cytoplasmic Potential
	Transmembrane	953 – 973	21	Helical; Name=S3 of repeat III; Potential
	Topological domain	974 – 979	6	Extracellular Potential
	Transmembrane	980 – 997	18	Helical; Voltage-sensor; Name=S4 of repeat III; Potential
	Topological domain	998 – 1015	18	Cytoplasmic Potential
	Transmembrane	1016 – 1036	21	Helical; Name=S5 of repeat III; Potential
	Topological domain	1037 – 1135	99	Extracellular Potential
	Transmembrane	1136 – 1156	21	Helical; Name=S6 of repeat III; Potential
	Topological domain	1157 – 1209	53	Cytoplasmic Potential
	Transmembrane	1210 – 1227	18	Helical; Name=S1 of repeat IV; Potential
	Topological domain	1228 – 1235	8	Extracellular Potential
	Transmembrane	1236 – 1256	21	Helical; Name=S2 of repeat IV; Potential
	Topological domain	1257 – 1277	21	Cytoplasmic Potential
	Transmembrane	1278 – 1298	21	Helical; Name=S3 of repeat IV; Potential
	Topological domain	1299	1	Extracellular Potential
	Transmembrane	1300 – 1316	17	Helical; Voltage-sensor; Name=S4 of repeat IV; Potential
	Topological domain	1317 – 1335	19	Cytoplasmic Potential
	Transmembrane	1336 – 1356	21	Helical; Name=S5 of repeat IV; Potential
	Topological domain	1357 – 1426	70	Extracellular Potential
	Transmembrane	1427 – 1447	21	Helical; Name=S6 of repeat IV; Potential
	Topological domain	1448 – 1738	291	Cytoplasmic Potential
	Coiled coil	795 – 830	36	Potential
Natural variations
	Alternative sequence	216 – 218	3	NVT → LSL in isoform 3.		VSP_030188
	Alternative sequence	219 – 1738	1520	Missing in isoform 3.		VSP_030189
	Alternative sequence	589 – 668	80	ILLSL…KQFID → PPSLIRDLCGTQDACPSCLP LQPPNHLPGSQTLARLTHQA LTTPPGMRSSQLFSKISLLL GICVAWESILGSLSLSHNLQ in isoform 2.		VSP_030190
	Alternative sequence	669 – 1738	1070	Missing in isoform 2.		VSP_030191

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 296BB66C9E443151	FASTA	1,738	200,331
	10 20 30 40 50 60 MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPMT 70 80 90 100 110 120 FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIVKGDS SYVKDRWCVF DGFMVFCLWV 130 140 150 160 170 180 SLVLQVFEIA DIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS 190 200 210 220 230 240 VSIFLLFFLL LYGILGVQMF GTFTYHCVVN DTKPGNVTWN SLAIPDTHCS PELEEGYQCP 250 260 270 280 290 300 PGFKCMDLED LGLSRQELGY SGFNEIGTSI FTVYEAASQE GWVFLMYRAI DSFPRWRSYF 310 320 330 340 350 360 YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGSRS STTSTATTQM FHEDAAGGWQ 370 380 390 400 410 420 LVAVDVNKPQ GRAPACLQKM MRSSVFHMFI LSMVTVDVIV AASNYYKGEN FRRQYDEFYL 430 440 450 460 470 480 AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVIG TTLHVYPDLY HSQFTYFQVL 490 500 510 520 530 540 RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF 550 560 570 580 590 600 PRAFMSMFQI LTQEGWVDVM DQTLNAVGHM WAPVVAIYFI LYHLFATLIL LSLFVAVILD 610 620 630 640 650 660 NLELDEDLKK LKQLKQSEAN ADTKEKLPLR LRIFEKFPNR PQMVKISKLP SDFTVPKIRE 670 680 690 700 710 720 SFMKQFIDRQ QQDTCCLLRS LPTTSSSSCD HSKRSAIEDN KYIDQKLRKS VFSIRARNLL 730 740 750 760 770 780 EKETAVTKIL RACTRQRMLS GSFEGQPAKE RSILSVQHHI RQERRSLRHG SNSQRISRGK 790 800 810 820 830 840 SLETLTQDHS NTVRYRNAQR EDSEIKMIQE KKEQAEMKRK VQEEELRENH PYFDKPLFIV 850 860 870 880 890 900 GREHRFRNFC RVVVRARFNA SKTDPVTGAV KNTKYHQLYD LLGLVTYLDW VMIIVTICSC 910 920 930 940 950 960 ISMMFESPFR RVMHAPTLQI AEYVFVIFMS IELNLKIMAD GLFFTPTAVI RDFGGVMDIF 970 980 990 1000 1010 1020 IYLVSLIFLC WMPQNVPAES GAQLLMVLRC LRPLRIFKLV PQMRKVVREL FSGFKEIFLV 1030 1040 1050 1060 1070 1080 SILLLTLMLV FASFGVQLFA GKLAKCNDPN IIRREDCNGI FRINVSVSKN LNLKLRPGEK 1090 1100 1110 1120 1130 1140 KPGFWVPRVW ANPRNFNFDN VGNAMLALFE VLSLKGWVEV RDVIIHRVGP IHGIYIHVFV 1150 1160 1170 1180 1190 1200 FLGCMIGLTL FVGVVIANFN ENKGTALLTV DQRRWEDLKS RLKIAQPLHL PPRPDNDGFR 1210 1220 1230 1240 1250 1260 AKMYDITQHP FFKRTIALLV LAQSVLLSVK WDVEDPVTVP LATMSVVFTF IFVLEVTMKI 1270 1280 1290 1300 1310 1320 IAMSPAGFWQ SRRNRYDLLV TSLGVVWVVL HFALLNAYTY MMGACVIVFR FFSICGKHVT 1330 1340 1350 1360 1370 1380 LKMLLLTVVV SMYKSFFIIV GMFLLLLCYA FAGVVLFGTV KYGENINRHA NFSSAGKAIT 1390 1400 1410 1420 1430 1440 VLFRIVTGED WNKIMHDCMV QPPFCTPDEF TYWATDCGNY AGALMYFCSF YVIIAYIMLN 1450 1460 1470 1480 1490 1500 LLVAIIVENF SLFYSTEEDQ LLSYNDLRHF QIIWNMVDDK REGVIPTFRV KFLLRLLRGR 1510 1520 1530 1540 1550 1560 LEVDLDKDKL LFKHMCYEME RLHNGGDVTF HDVLSMLSYR SVDIRKSLQL EELLAREQLE 1570 1580 1590 1600 1610 1620 YTIEEEVAKQ TIRMWLKKCL KRIRAKQQQS CSIIHSLRES QQQELSRFLN PPSIETTQPS 1630 1640 1650 1660 1670 1680 EDTNANSQDN SMQPETSSQQ QLLSPTLSDR GGSRQDAADA GKPQRKFGQW RLPSAPKPIS 1690 1700 1710 1720 1730 HSVSSVNLRF GGRTTMKSVV CKMNPMTDAA SCGSEVKKWW TRQLTVESDE SGDDLLDI
	Isoform 2 [UniParc]. Checksum: 2796438CB6835D70	FASTA	668	76,382
	10 20 30 40 50 60 MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPMT 70 80 90 100 110 120 FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIVKGDS SYVKDRWCVF DGFMVFCLWV 130 140 150 160 170 180 SLVLQVFEIA DIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS 190 200 210 220 230 240 VSIFLLFFLL LYGILGVQMF GTFTYHCVVN DTKPGNVTWN SLAIPDTHCS PELEEGYQCP 250 260 270 280 290 300 PGFKCMDLED LGLSRQELGY SGFNEIGTSI FTVYEAASQE GWVFLMYRAI DSFPRWRSYF 310 320 330 340 350 360 YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGSRS STTSTATTQM FHEDAAGGWQ 370 380 390 400 410 420 LVAVDVNKPQ GRAPACLQKM MRSSVFHMFI LSMVTVDVIV AASNYYKGEN FRRQYDEFYL 430 440 450 460 470 480 AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVIG TTLHVYPDLY HSQFTYFQVL 490 500 510 520 530 540 RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF 550 560 570 580 590 600 PRAFMSMFQI LTQEGWVDVM DQTLNAVGHM WAPVVAIYFI LYHLFATLPP SLIRDLCGTQ 610 620 630 640 650 660 DACPSCLPLQ PPNHLPGSQT LARLTHQALT TPPGMRSSQL FSKISLLLGI CVAWESILGS LSLSHNLQ
	Isoform 3 [UniParc]. Checksum: 7AB53C2FDB715FBE	FASTA	218	25,365
	10 20 30 40 50 60 MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPMT 70 80 90 100 110 120 FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIVKGDS SYVKDRWCVF DGFMVFCLWV 130 140 150 160 170 180 SLVLQVFEIA DIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS 190 200 210 VSIFLLFFLL LYGILGVQMF GTFTYHCVVN DTKPGLSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"VGCNL1, a putative voltage-gated ion channel." Bonner T.I., Moses T., Detera-Wadleigh S. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Bone and Brain.
[5]	"Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia." Chumakov I., Blumenfeld M., Guerassimenko O., Cavarec L., Palicio M., Abderrahim H., Bougueleret L., Barry C., Tanaka H., La Rosa P., Puech A., Tahri N., Cohen-Akenine A., Delabrosse S., Lissarrague S., Picard F.-P., Maurice K., Essioux L. , Millasseau P., Grel P., Debailleul V., Simon A.-M., Caterina D., Dufaure I., Malekzadeh K., Belova M., Luan J.-J., Bouillot M., Sambucy J.-L., Primas G., Saumier M., Boubkiri N., Martin-Saumier S., Nasroune M., Peixoto H., Delaye A., Pinchot V., Bastucci M., Guillou S., Chevillon M., Sainz-Fuertes R., Meguenni S., Aurich-Costa J., Cherif D., Gimalac A., Van Duijn C., Gauvreau D., Ouellette G., Fortier I., Raelson J., Sherbatich T., Riazanskay N., Rogaev E., Raeymaekers P., Aerssens J., Konings F., Luyten W., Macciardi F., Sham P.C., Straub R.E., Weinberger D.R., Cohen N., Cohen D. Proc. Natl. Acad. Sci. U.S.A. 99:13675-13680(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-266.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1428-1738.
[7]	"The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm." Lu B., Su Y., Das S., Liu J., Xia J., Ren D. Cell 129:371-383(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY141972 mRNA. Translation: AAN10255.1. AL354891, AL138707, AL356778 Genomic DNA. Translation: CAH73919.1. AL356778, AL138707, AL354891 Genomic DNA. Translation: CAI16648.1. AL138707, AL354891, AL356778 Genomic DNA. Translation: CAI40711.1. CH471085 Genomic DNA. Translation: EAX09045.1. BC028390 mRNA. Translation: AAH28390.1. BC064343 mRNA. Translation: AAH64343.1. AE014293 Genomic DNA. Translation: AAN16023.1. AK172752 mRNA. Translation: BAD18738.1. Different initiation.
IPI	IPI00217996. IPI00827756. IPI01011084.
RefSeq	NP_443099.1. NM_052867.2.
UniGene	Hs.525146.
3D structure databases
ProteinModelPortal	Q8IZF0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000251127.
Protein family/group databases
TCDB	1.A.1.11.15. voltage-gated ion channel (VIC) superfamily.
PTM databases
PhosphoSite	Q8IZF0.
Polymorphism databases
DMDM	74750791.
Proteomic databases
PaxDb	Q8IZF0.
PRIDE	Q8IZF0.
Protocols and materials databases
DNASU	259232.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000251127; ENSP00000251127; ENSG00000102452. ENST00000376200; ENSP00000365373; ENSG00000102452.
GeneID	259232.
KEGG	hsa:259232.
UCSC	uc001vox.1. human.
Organism-specific databases
CTD	259232.
GeneCards	GC13M101706.
H-InvDB	HIX0011433.
HGNC	HGNC:19082. NALCN.
HPA	HPA031889. HPA031890. HPA031958.
MIM	611549. gene.
neXtProt	NX_Q8IZF0.
PharmGKB	PA162396840.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG268129.
HOGENOM	HOG000012967.
HOVERGEN	HBG063081.
InParanoid	Q8IZF0.
OMA	MIVVTIC.
OrthoDB	EOG4R501V.
PhylomeDB	Q8IZF0.
Gene expression databases
ArrayExpress	Q8IZF0.
Bgee	Q8IZF0.
CleanEx	HS_NALCN.
Genevestigator	Q8IZF0.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. [Graphical view]
Pfam	PF00520. Ion_trans. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1628464.
ChiTaRS	NALCN. human.
GenomeRNAi	259232.
NextBio	93066.
SOURCE	Search...

Entry information

Entry name

NALCN_HUMAN

Accession

Primary (citable) accession number: Q8IZF0
Secondary accession number(s): Q6P2S6 , Q6ZMI7, Q8IZZ1, Q8TAH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.